PES1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)6.69399108
2protein K11-linked deubiquitination (GO:0035871)4.34618156
3regulation of DNA endoreduplication (GO:0032875)4.30103543
4cell wall macromolecule catabolic process (GO:0016998)4.14137263
5negative regulation of dendrite development (GO:2000171)4.13298048
6negative regulation of dendrite morphogenesis (GO:0050774)4.10048668
7auditory receptor cell stereocilium organization (GO:0060088)3.92050707
8presynaptic membrane assembly (GO:0097105)3.86734145
9positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.82412883
10signal peptide processing (GO:0006465)3.79956515
11cell wall macromolecule metabolic process (GO:0044036)3.79379570
12detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.78854806
13regulation of hexokinase activity (GO:1903299)3.67581386
14regulation of glucokinase activity (GO:0033131)3.67581386
15negative regulation of translation, ncRNA-mediated (GO:0040033)3.65282861
16regulation of translation, ncRNA-mediated (GO:0045974)3.65282861
17negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.65282861
18monoubiquitinated protein deubiquitination (GO:0035520)3.65216993
19cellular ketone body metabolic process (GO:0046950)3.64712140
20positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)3.60065026
21epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.59351969
22heparin biosynthetic process (GO:0030210)3.58302309
23heparin metabolic process (GO:0030202)3.58302309
24inner ear receptor stereocilium organization (GO:0060122)3.56512188
25positive regulation of neurological system process (GO:0031646)3.48687614
26negative regulation of cytosolic calcium ion concentration (GO:0051481)3.48360364
27response to gravity (GO:0009629)3.41836307
28platelet dense granule organization (GO:0060155)3.34867826
29cerebral cortex radially oriented cell migration (GO:0021799)3.32569166
30startle response (GO:0001964)3.29206217
31positive regulation of glomerulus development (GO:0090193)3.28861508
32negative regulation of astrocyte differentiation (GO:0048712)3.28772641
33limb bud formation (GO:0060174)3.27605355
34ketone body metabolic process (GO:1902224)3.24023891
35postsynaptic membrane organization (GO:0001941)3.22836806
36lung vasculature development (GO:0060426)3.20694003
37regulation of meiosis I (GO:0060631)3.19364902
38mitochondrial DNA replication (GO:0006264)3.17383125
39regulation of cilium movement (GO:0003352)3.13806131
40protein localization to cilium (GO:0061512)3.13726297
41retinal metabolic process (GO:0042574)3.12391679
42epithelial cilium movement (GO:0003351)3.11271835
43presynaptic membrane organization (GO:0097090)3.11240960
44coenzyme catabolic process (GO:0009109)3.08300891
45replication fork processing (GO:0031297)3.08234712
46anterograde synaptic vesicle transport (GO:0048490)3.03864893
47regulation of oxidative stress-induced neuron death (GO:1903203)3.03201138
48transepithelial transport (GO:0070633)2.99441244
49cilium movement (GO:0003341)2.97607278
50negative regulation of cAMP-mediated signaling (GO:0043951)2.94695675
51respiratory tube development (GO:0030323)2.87210980
52response to pheromone (GO:0019236)2.80521077
53piRNA metabolic process (GO:0034587)2.78251728
54centriole replication (GO:0007099)2.77144621
55positive regulation of vasculogenesis (GO:2001214)2.74506957
56detection of light stimulus involved in visual perception (GO:0050908)2.74139495
57detection of light stimulus involved in sensory perception (GO:0050962)2.74139495
58regulation of transmission of nerve impulse (GO:0051969)2.73136544
59indolalkylamine catabolic process (GO:0046218)2.71425757
60tryptophan catabolic process (GO:0006569)2.71425757
61indole-containing compound catabolic process (GO:0042436)2.71425757
62limb development (GO:0060173)2.70028383
63appendage development (GO:0048736)2.70028383
64detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.69978630
65somite development (GO:0061053)2.68924179
66retinal cone cell development (GO:0046549)2.68370363
67negative regulation of keratinocyte proliferation (GO:0010839)2.67839049
68indolalkylamine metabolic process (GO:0006586)2.66685674
69negative regulation of systemic arterial blood pressure (GO:0003085)2.66265477
70negative regulation of neurotransmitter transport (GO:0051589)2.65589346
71serotonin metabolic process (GO:0042428)2.65345197
72negative regulation of neurotransmitter secretion (GO:0046929)2.65200595
73cilium assembly (GO:0042384)2.62810468
74axoneme assembly (GO:0035082)2.62797978
75C4-dicarboxylate transport (GO:0015740)2.61406116
76regulation of timing of cell differentiation (GO:0048505)2.61346510
77embryonic epithelial tube formation (GO:0001838)2.60695145
78cilium organization (GO:0044782)2.60473929
79sperm motility (GO:0030317)2.59323010
80protein polyglutamylation (GO:0018095)2.59012792
81axonemal dynein complex assembly (GO:0070286)2.57036227
82gamma-aminobutyric acid transport (GO:0015812)2.56067961
83regulation of protein glycosylation (GO:0060049)2.55640170
84establishment of protein localization to Golgi (GO:0072600)2.54935198
85atrial cardiac muscle cell action potential (GO:0086014)2.54838729
86regulation of axon regeneration (GO:0048679)2.53875820
87regulation of neuron projection regeneration (GO:0070570)2.53875820
88detection of mechanical stimulus involved in sensory perception (GO:0050974)2.53326855
89activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.49886881
90intraciliary transport (GO:0042073)2.46479433
91negative regulation of transcription regulatory region DNA binding (GO:2000678)2.44582658
92cilium or flagellum-dependent cell motility (GO:0001539)2.42522775
93establishment of monopolar cell polarity (GO:0061162)2.41355128
94establishment or maintenance of monopolar cell polarity (GO:0061339)2.41355128
95epithelial tube formation (GO:0072175)2.40981554
96regulation of sarcomere organization (GO:0060297)2.40121130
97cilium morphogenesis (GO:0060271)2.40026453
98nonmotile primary cilium assembly (GO:0035058)2.39855986
99regulation of glomerulus development (GO:0090192)2.39578762
100indole-containing compound metabolic process (GO:0042430)2.39252505

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse5.90699690
2VDR_22108803_ChIP-Seq_LS180_Human3.60394681
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.82612468
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.74414424
5GBX2_23144817_ChIP-Seq_PC3_Human2.67112649
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.59039284
7ZNF274_21170338_ChIP-Seq_K562_Hela2.55773592
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36471284
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.32110310
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.30400479
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.29714416
12P300_19829295_ChIP-Seq_ESCs_Human2.29474204
13FUS_26573619_Chip-Seq_HEK293_Human2.17811842
14AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.15424734
15PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.10951170
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.05453651
17BCAT_22108803_ChIP-Seq_LS180_Human2.05366726
18TAF15_26573619_Chip-Seq_HEK293_Human2.02505282
19CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01303545
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.91582384
21IGF1R_20145208_ChIP-Seq_DFB_Human1.89121872
22ER_23166858_ChIP-Seq_MCF-7_Human1.83189502
23AR_21572438_ChIP-Seq_LNCaP_Human1.81872596
24SMAD4_21799915_ChIP-Seq_A2780_Human1.79618785
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79024182
26EWS_26573619_Chip-Seq_HEK293_Human1.76597656
27EZH2_22144423_ChIP-Seq_EOC_Human1.73242078
28AR_25329375_ChIP-Seq_VCAP_Human1.71078334
29EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.68396007
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64502623
31UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62510894
32MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62347410
33SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60765412
34STAT3_23295773_ChIP-Seq_U87_Human1.60432857
35SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.59530738
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.56328297
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54023408
38TCF4_23295773_ChIP-Seq_U87_Human1.51437012
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51171131
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.51109718
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49303630
42CBP_20019798_ChIP-Seq_JUKART_Human1.49303630
43OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48001903
44NR3C1_21868756_ChIP-Seq_MCF10A_Human1.47890368
45TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45837511
46POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.45837511
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45559588
48SOX2_19829295_ChIP-Seq_ESCs_Human1.41511923
49NANOG_19829295_ChIP-Seq_ESCs_Human1.41511923
50TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41010884
51ARNT_22903824_ChIP-Seq_MCF-7_Human1.37142866
52TCF4_22108803_ChIP-Seq_LS180_Human1.36879945
53E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36519940
54CJUN_26792858_Chip-Seq_BT549_Human1.34979758
55GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33576619
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31980415
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.31856686
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29850669
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.29443486
60KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23351125
61AHR_22903824_ChIP-Seq_MCF-7_Human1.23170143
62CBX2_27304074_Chip-Seq_ESCs_Mouse1.23158176
63ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23055426
64SMAD4_21741376_ChIP-Seq_EPCs_Human1.20677664
65CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.20501845
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19864763
67FOXM1_26456572_ChIP-Seq_MCF-7_Human1.19178994
68RXR_22108803_ChIP-Seq_LS180_Human1.19004982
69TP53_18474530_ChIP-ChIP_U2OS_Human1.18350809
70BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18213186
71NFE2_27457419_Chip-Seq_LIVER_Mouse1.17881876
72EP300_21415370_ChIP-Seq_HL-1_Mouse1.16290701
73CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.14880901
74CDX2_22108803_ChIP-Seq_LS180_Human1.14798475
75FLI1_21867929_ChIP-Seq_TH2_Mouse1.13814289
76CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13418717
77NANOG_18555785_Chip-Seq_ESCs_Mouse1.12258627
78RUNX2_22187159_ChIP-Seq_PCA_Human1.12191523
79TBL1_22424771_ChIP-Seq_293T_Human1.10353896
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09042868
81KDM2B_26808549_Chip-Seq_REH_Human1.08466895
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08334860
83SOX2_21211035_ChIP-Seq_LN229_Gbm1.06647648
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03966645
85GATA1_22025678_ChIP-Seq_K562_Human1.03826893
86TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03759950
87NFYB_21822215_ChIP-Seq_K562_Human1.03697864
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03461826
89TP53_22573176_ChIP-Seq_HFKS_Human1.03131670
90P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02608812
91TP53_16413492_ChIP-PET_HCT116_Human1.02182954
92CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.01891358
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01814428
94FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01790788
95ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.01750572
96REST_21632747_ChIP-Seq_MESCs_Mouse1.01396136
97NOTCH1_21737748_ChIP-Seq_TLL_Human1.01358974
98P53_22387025_ChIP-Seq_ESCs_Mouse0.99669031
99CRX_20693478_ChIP-Seq_RETINA_Mouse0.98640320
100STAT3_18555785_Chip-Seq_ESCs_Mouse0.98514002

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.10855262
2MP0005646_abnormal_pituitary_gland3.41282313
3MP0003195_calcinosis3.05229350
4MP0003880_abnormal_central_pattern2.74981981
5MP0006292_abnormal_olfactory_placode2.55579394
6MP0002736_abnormal_nociception_after2.49663418
7MP0002928_abnormal_bile_duct2.48213866
8MP0001501_abnormal_sleep_pattern2.38501898
9MP0008877_abnormal_DNA_methylation2.20605809
10MP0002234_abnormal_pharynx_morphology2.17639080
11MP0001968_abnormal_touch/_nociception2.08478802
12MP0002163_abnormal_gland_morphology2.08459419
13MP0005551_abnormal_eye_electrophysiolog2.07107471
14MP0009053_abnormal_anal_canal2.03428604
15MP0003646_muscle_fatigue2.00711901
16MP0001986_abnormal_taste_sensitivity1.90287096
17MP0010386_abnormal_urinary_bladder1.83599914
18MP0001486_abnormal_startle_reflex1.83460362
19MP0000631_abnormal_neuroendocrine_gland1.79884338
20MP0009745_abnormal_behavioral_response1.78101747
21MP0005084_abnormal_gallbladder_morpholo1.60295955
22MP0008789_abnormal_olfactory_epithelium1.59406018
23MP0001764_abnormal_homeostasis1.58471129
24MP0002168_other_aberrant_phenotype1.55537304
25MP0005379_endocrine/exocrine_gland_phen1.55487880
26MP0008058_abnormal_DNA_repair1.53885346
27MP0003950_abnormal_plasma_membrane1.51867605
28MP0009046_muscle_twitch1.49242369
29MP0006072_abnormal_retinal_apoptosis1.48095719
30MP0008872_abnormal_physiological_respon1.46981346
31MP0005248_abnormal_Harderian_gland1.45112700
32MP0002822_catalepsy1.42297914
33MP0002938_white_spotting1.42292832
34MP0006276_abnormal_autonomic_nervous1.38594740
35MP0000538_abnormal_urinary_bladder1.37773370
36MP0003937_abnormal_limbs/digits/tail_de1.37516951
37MP0005167_abnormal_blood-brain_barrier1.37380128
38MP0005395_other_phenotype1.36119669
39MP0002272_abnormal_nervous_system1.35693606
40MP0005408_hypopigmentation1.33786278
41MP0003718_maternal_effect1.31642520
42MP0005645_abnormal_hypothalamus_physiol1.29294861
43MP0002557_abnormal_social/conspecific_i1.25948086
44MP0005410_abnormal_fertilization1.24345819
45MP0004019_abnormal_vitamin_homeostasis1.22805379
46MP0005253_abnormal_eye_physiology1.21709732
47MP0001485_abnormal_pinna_reflex1.20560293
48MP0000613_abnormal_salivary_gland1.18044779
49MP0005085_abnormal_gallbladder_physiolo1.14645246
50MP0004133_heterotaxia1.12569418
51MP0000778_abnormal_nervous_system1.11995420
52MP0003938_abnormal_ear_development1.09762487
53MP0005174_abnormal_tail_pigmentation1.09688787
54MP0005423_abnormal_somatic_nervous1.09015245
55MP0003633_abnormal_nervous_system1.08174373
56MP0004885_abnormal_endolymph1.06360917
57MP0003943_abnormal_hepatobiliary_system1.05831066
58MP0010678_abnormal_skin_adnexa1.05488863
59MP0010094_abnormal_chromosome_stability1.05486804
60MP0002733_abnormal_thermal_nociception1.04657001
61MP0009780_abnormal_chondrocyte_physiolo1.02250925
62MP0001970_abnormal_pain_threshold0.99400225
63MP0004134_abnormal_chest_morphology0.96894190
64MP0003121_genomic_imprinting0.96609677
65MP0001929_abnormal_gametogenesis0.95073275
66MP0000653_abnormal_sex_gland0.94944761
67MP0008057_abnormal_DNA_replication0.93156429
68MP0003698_abnormal_male_reproductive0.92934504
69MP0001177_atelectasis0.92160445
70MP0002735_abnormal_chemical_nociception0.90178668
71MP0002138_abnormal_hepatobiliary_system0.89391713
72MP0002572_abnormal_emotion/affect_behav0.89364153
73MP0005195_abnormal_posterior_eye0.89177467
74MP0002233_abnormal_nose_morphology0.86656275
75MP0003119_abnormal_digestive_system0.86620151
76MP0003252_abnormal_bile_duct0.85912089
77MP0009250_abnormal_appendicular_skeleto0.84924777
78MP0004145_abnormal_muscle_electrophysio0.84291368
79MP0004085_abnormal_heartbeat0.84061913
80MP0000049_abnormal_middle_ear0.83909638
81MP0003942_abnormal_urinary_system0.83494165
82MP0002210_abnormal_sex_determination0.83172366
83MP0002064_seizures0.81063357
84MP0005394_taste/olfaction_phenotype0.81025254
85MP0005499_abnormal_olfactory_system0.81025254
86MP0005391_vision/eye_phenotype0.80542304
87MP0010368_abnormal_lymphatic_system0.80435980
88MP0000026_abnormal_inner_ear0.80213458
89MP0003755_abnormal_palate_morphology0.79995976
90MP0002282_abnormal_trachea_morphology0.79119589
91MP0000383_abnormal_hair_follicle0.78700536
92MP0000015_abnormal_ear_pigmentation0.78471323
93MP0003045_fibrosis0.77977921
94MP0001145_abnormal_male_reproductive0.76850075
95MP0001963_abnormal_hearing_physiology0.75300415
96MP0005647_abnormal_sex_gland0.75090025
97MP0000647_abnormal_sebaceous_gland0.74914198
98MP0004215_abnormal_myocardial_fiber0.74137500
99MP0000516_abnormal_urinary_system0.74074500
100MP0005367_renal/urinary_system_phenotyp0.74074500

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.27517867
2True hermaphroditism (HP:0010459)4.16154939
3Atonic seizures (HP:0010819)4.01358387
4Pancreatic fibrosis (HP:0100732)3.85560766
5Type II lissencephaly (HP:0007260)3.81665267
6Pendular nystagmus (HP:0012043)3.50081594
7Febrile seizures (HP:0002373)3.32869972
8Neoplasm of the adrenal cortex (HP:0100641)3.20172948
9Stomach cancer (HP:0012126)3.17591412
10Retinal dysplasia (HP:0007973)2.99192216
11Hyperventilation (HP:0002883)2.97676272
12Chorioretinal atrophy (HP:0000533)2.94968381
13Ectopic kidney (HP:0000086)2.93597248
14Slender build (HP:0001533)2.90970160
15Cystic liver disease (HP:0006706)2.87386960
16Congenital sensorineural hearing impairment (HP:0008527)2.85668007
17Increased corneal curvature (HP:0100692)2.79880281
18Keratoconus (HP:0000563)2.79880281
19Glioma (HP:0009733)2.79104020
20Abnormality of macular pigmentation (HP:0008002)2.76397968
21Abnormal biliary tract physiology (HP:0012439)2.73598918
22Bile duct proliferation (HP:0001408)2.73598918
23Abnormality of the astrocytes (HP:0100707)2.70915694
24Astrocytoma (HP:0009592)2.70915694
25Severe visual impairment (HP:0001141)2.69938358
26Widely spaced teeth (HP:0000687)2.69465460
27Gaze-evoked nystagmus (HP:0000640)2.65911663
28Abnormality of the renal cortex (HP:0011035)2.62257072
29Abnormality of the renal medulla (HP:0100957)2.60626148
30Chronic hepatic failure (HP:0100626)2.56997879
31Nephronophthisis (HP:0000090)2.54756571
32Abnormality of midbrain morphology (HP:0002418)2.51583712
33Molar tooth sign on MRI (HP:0002419)2.51583712
34Tubular atrophy (HP:0000092)2.46153982
35Attenuation of retinal blood vessels (HP:0007843)2.44081214
36Albinism (HP:0001022)2.42523287
37Aplasia/Hypoplasia of the tongue (HP:0010295)2.42063535
38Abnormality of the nasal septum (HP:0000419)2.40984373
39Cerebellar dysplasia (HP:0007033)2.37649839
40Absent speech (HP:0001344)2.34304996
41Congenital stationary night blindness (HP:0007642)2.33909332
42Progressive cerebellar ataxia (HP:0002073)2.33766120
43Methylmalonic acidemia (HP:0002912)2.33481728
44Hypoplastic ischia (HP:0003175)2.31295694
45Absence seizures (HP:0002121)2.31060225
46Epidermoid cyst (HP:0200040)2.29697857
47Bony spicule pigmentary retinopathy (HP:0007737)2.27333836
48Abnormal rod and cone electroretinograms (HP:0008323)2.27248350
49Abnormal drinking behavior (HP:0030082)2.25739423
50Polydipsia (HP:0001959)2.25739423
51Sclerocornea (HP:0000647)2.25105720
52Absent/shortened dynein arms (HP:0200106)2.23735451
53Dynein arm defect of respiratory motile cilia (HP:0012255)2.23735451
54Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.22181564
55Exertional dyspnea (HP:0002875)2.20695350
56Occipital encephalocele (HP:0002085)2.20349895
57Fair hair (HP:0002286)2.19730839
58Intestinal atresia (HP:0011100)2.18634266
59Furrowed tongue (HP:0000221)2.17855489
60Congenital hepatic fibrosis (HP:0002612)2.16753463
61Thyroiditis (HP:0100646)2.14320846
62Volvulus (HP:0002580)2.12565282
63Megalencephaly (HP:0001355)2.11979825
64Tented upper lip vermilion (HP:0010804)2.08498817
65Dialeptic seizures (HP:0011146)2.03332594
66Pachygyria (HP:0001302)2.03278997
67Decreased central vision (HP:0007663)2.02877422
68Anencephaly (HP:0002323)2.02259797
69Abolished electroretinogram (ERG) (HP:0000550)1.98506468
70Absent rod-and cone-mediated responses on ERG (HP:0007688)1.96910270
71Abnormality of the ischium (HP:0003174)1.95811324
72Hamartoma of the eye (HP:0010568)1.94720117
73Dyskinesia (HP:0100660)1.93848964
74Abnormality of the costochondral junction (HP:0000919)1.93028372
75Abnormal respiratory motile cilium morphology (HP:0005938)1.92030271
76Abnormal respiratory epithelium morphology (HP:0012253)1.92030271
77Methylmalonic aciduria (HP:0012120)1.91990900
78Neoplasm of the adrenal gland (HP:0100631)1.91988007
79Optic nerve hypoplasia (HP:0000609)1.91368769
80Male pseudohermaphroditism (HP:0000037)1.88504622
81Generalized myoclonic seizures (HP:0002123)1.87350809
82Hemiparesis (HP:0001269)1.87318885
83Colon cancer (HP:0003003)1.85872087
84Drooling (HP:0002307)1.85490620
85Aqueductal stenosis (HP:0002410)1.85414748
86Exocrine pancreatic insufficiency (HP:0001738)1.85142468
87Abnormality of vitamin B metabolism (HP:0004340)1.80950604
88Adrenal hypoplasia (HP:0000835)1.80180198
89Abnormal respiratory motile cilium physiology (HP:0012261)1.79816837
90Hypsarrhythmia (HP:0002521)1.79067248
91Medulloblastoma (HP:0002885)1.78926437
92Abnormal ciliary motility (HP:0012262)1.77199476
93Papillary thyroid carcinoma (HP:0002895)1.77068260
94Constricted visual fields (HP:0001133)1.76788596
95Lissencephaly (HP:0001339)1.75665863
96Meningioma (HP:0002858)1.75330814
97Epileptiform EEG discharges (HP:0011182)1.73998765
98Rectal prolapse (HP:0002035)1.73104980
99EEG with generalized epileptiform discharges (HP:0011198)1.72768099
100Bone cyst (HP:0012062)1.72723168

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.25328773
2BRSK23.30542252
3MAP4K23.26269342
4PDK23.19012612
5WEE12.93506405
6LMTK22.63030800
7PINK12.54848490
8TNIK2.36290848
9NUAK12.32742679
10PLK22.28427763
11STK38L2.08905516
12BMPR1B2.01026398
13EPHA41.89622862
14ADRBK21.88211115
15CASK1.81442834
16MST41.77887718
17ERBB31.72859676
18INSRR1.71820261
19FGFR21.62129389
20TRIM281.57917739
21PNCK1.46436572
22BRD41.44396806
23WNK31.37828611
24STK161.35272942
25ACVR1B1.33393233
26GRK11.29836910
27PLK41.28676765
28PKN11.19073834
29BRSK11.18087105
30MAPK131.17634051
31PRKCE1.14840846
32NEK61.08407110
33SIK31.07594607
34STK391.06958959
35ZAK1.05599544
36BCR1.05055418
37TIE11.03392342
38OXSR11.01283426
39MKNK20.99108919
40NEK10.94984630
41DYRK20.94557880
42ADRBK10.91432903
43STK380.91105681
44EIF2AK30.85652904
45ROCK10.84791635
46MAPK70.75813219
47CSNK1G10.73945456
48GRK50.72812075
49PAK30.72714037
50NTRK30.72213174
51TNK20.70917693
52DMPK0.68148396
53PRKCI0.64260318
54MINK10.64069557
55TAOK30.62447757
56HIPK20.61181841
57PIK3CA0.60266346
58CSNK1G30.59779313
59GRK70.59545454
60PTK2B0.59487379
61DAPK20.59237523
62FGFR10.58545831
63EIF2AK20.54724251
64MARK10.53416709
65SRPK10.52413690
66CSNK1A10.52231675
67CSNK1G20.52080941
68PLK30.49523342
69FGFR30.47888988
70CSNK1A1L0.47816478
71PRKG10.45496339
72PRKG20.44562403
73CAMK10.43864227
74STK100.42602399
75PRKCG0.41710657
76MAP2K60.40348149
77PRKD30.39989100
78FER0.39759391
79TGFBR20.39581396
80NTRK20.39350132
81TGFBR10.36677186
82NLK0.35487077
83BUB10.35160096
84PRKCQ0.34061681
85STK30.33321811
86MAP3K70.33119469
87PRKACA0.32821152
88CAMK2A0.32475793
89ATM0.32400472
90STK110.31872725
91PRKCZ0.31564690
92CDK190.31347489
93VRK20.31279078
94CCNB10.31022550
95TRPM70.30738503
96LATS10.30653515
97CAMK40.30595068
98IKBKB0.26671993
99NME10.26501638
100PLK10.25884133

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.27196266
2Non-homologous end-joining_Homo sapiens_hsa034503.32356241
3Phototransduction_Homo sapiens_hsa047442.61583173
4Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.60728359
5Butanoate metabolism_Homo sapiens_hsa006502.53867626
6Nitrogen metabolism_Homo sapiens_hsa009102.49671603
7Selenocompound metabolism_Homo sapiens_hsa004502.36999872
8Protein export_Homo sapiens_hsa030602.36075822
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.13412972
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.89066787
11Olfactory transduction_Homo sapiens_hsa047401.80855944
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.74606928
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.70181923
14Linoleic acid metabolism_Homo sapiens_hsa005911.69566248
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.69316359
16Propanoate metabolism_Homo sapiens_hsa006401.68494595
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.68021561
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.66307698
19Circadian rhythm_Homo sapiens_hsa047101.62959878
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.53393487
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.51990218
22Tryptophan metabolism_Homo sapiens_hsa003801.51063251
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.50814347
24ABC transporters_Homo sapiens_hsa020101.50477764
25Homologous recombination_Homo sapiens_hsa034401.50003164
26Nicotine addiction_Homo sapiens_hsa050331.37420052
27Glycerolipid metabolism_Homo sapiens_hsa005611.33815745
28Mineral absorption_Homo sapiens_hsa049781.31619884
29Ether lipid metabolism_Homo sapiens_hsa005651.30745717
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.29793673
31Lysine degradation_Homo sapiens_hsa003101.25906737
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.23146506
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17960420
34Fanconi anemia pathway_Homo sapiens_hsa034601.16988015
35Collecting duct acid secretion_Homo sapiens_hsa049661.15076720
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09261409
37Morphine addiction_Homo sapiens_hsa050321.07223615
38Glutamatergic synapse_Homo sapiens_hsa047241.04608464
39Caffeine metabolism_Homo sapiens_hsa002321.04146712
40Sphingolipid metabolism_Homo sapiens_hsa006001.03289648
41Basal transcription factors_Homo sapiens_hsa030221.02292809
42Taste transduction_Homo sapiens_hsa047420.96400466
43Fatty acid degradation_Homo sapiens_hsa000710.94203802
44Insulin secretion_Homo sapiens_hsa049110.93935554
45GABAergic synapse_Homo sapiens_hsa047270.92980525
46Steroid hormone biosynthesis_Homo sapiens_hsa001400.92125093
47Peroxisome_Homo sapiens_hsa041460.92040861
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91359003
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90478201
50Bile secretion_Homo sapiens_hsa049760.87845471
51Circadian entrainment_Homo sapiens_hsa047130.87010143
52TGF-beta signaling pathway_Homo sapiens_hsa043500.84879795
53Regulation of autophagy_Homo sapiens_hsa041400.83158063
54Basal cell carcinoma_Homo sapiens_hsa052170.80736628
55beta-Alanine metabolism_Homo sapiens_hsa004100.80446922
56Chemical carcinogenesis_Homo sapiens_hsa052040.80127785
57Dorso-ventral axis formation_Homo sapiens_hsa043200.79732832
58Hedgehog signaling pathway_Homo sapiens_hsa043400.79523245
59Pancreatic secretion_Homo sapiens_hsa049720.74888633
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74690359
61Hippo signaling pathway_Homo sapiens_hsa043900.74395943
62Retinol metabolism_Homo sapiens_hsa008300.73647627
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69625238
64Thyroid hormone synthesis_Homo sapiens_hsa049180.69211040
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68967553
66Salivary secretion_Homo sapiens_hsa049700.67732599
67cAMP signaling pathway_Homo sapiens_hsa040240.66997290
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64203452
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63274735
70Fatty acid metabolism_Homo sapiens_hsa012120.63245915
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61023978
72Serotonergic synapse_Homo sapiens_hsa047260.60868561
73Sulfur metabolism_Homo sapiens_hsa009200.58567221
74RNA polymerase_Homo sapiens_hsa030200.57468706
75Oocyte meiosis_Homo sapiens_hsa041140.57025841
76Fatty acid elongation_Homo sapiens_hsa000620.56807734
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55617797
78Gastric acid secretion_Homo sapiens_hsa049710.54145672
79Dopaminergic synapse_Homo sapiens_hsa047280.53066496
80One carbon pool by folate_Homo sapiens_hsa006700.52036128
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51673880
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51486854
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.51448161
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.49822613
85Arginine and proline metabolism_Homo sapiens_hsa003300.49208371
86Cholinergic synapse_Homo sapiens_hsa047250.48982556
87Calcium signaling pathway_Homo sapiens_hsa040200.48565307
88Purine metabolism_Homo sapiens_hsa002300.46640574
89Amphetamine addiction_Homo sapiens_hsa050310.41820482
90Metabolic pathways_Homo sapiens_hsa011000.39076423
91Fat digestion and absorption_Homo sapiens_hsa049750.38355815
92Arachidonic acid metabolism_Homo sapiens_hsa005900.38181513
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37754309
94Histidine metabolism_Homo sapiens_hsa003400.37481334
95Oxidative phosphorylation_Homo sapiens_hsa001900.36844903
96PPAR signaling pathway_Homo sapiens_hsa033200.33731278
97Folate biosynthesis_Homo sapiens_hsa007900.32251208
98Cocaine addiction_Homo sapiens_hsa050300.31596568
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31482134
100Tight junction_Homo sapiens_hsa045300.30846008

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