PET100

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mitochondrial complex IV, or cytochrome c oxidase, is a large transmembrane protein complex that is part of the respiratory electron transport chain of mitochondria. The small protein encoded by this gene plays a role in the biogenesis of mitochondrial complex IV. This protein localizes to the inner mitochondrial membrane and is exposed to the intermembrane space. Mutations in this gene are associated with mitochondrial complex IV deficiency. This gene has a pseudogene on chromosome 3. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.14827961
2central nervous system myelination (GO:0022010)7.14827961
3mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.76818589
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.67190362
5ATP synthesis coupled proton transport (GO:0015986)6.50026899
6energy coupled proton transport, down electrochemical gradient (GO:0015985)6.50026899
7respiratory electron transport chain (GO:0022904)5.66681223
8fatty acid elongation (GO:0030497)5.59644155
9electron transport chain (GO:0022900)5.51725828
10sequestering of actin monomers (GO:0042989)5.16010905
11protein neddylation (GO:0045116)5.13904685
12chaperone-mediated protein transport (GO:0072321)5.00807111
13maturation of SSU-rRNA (GO:0030490)4.88280140
14long-chain fatty acid biosynthetic process (GO:0042759)4.78305352
15ribosomal small subunit biogenesis (GO:0042274)4.45338450
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.31651274
17translational initiation (GO:0006413)4.16921044
18mitochondrial respiratory chain complex I assembly (GO:0032981)4.14278844
19NADH dehydrogenase complex assembly (GO:0010257)4.14278844
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.14278844
21protein complex biogenesis (GO:0070271)4.05848471
22cytochrome complex assembly (GO:0017004)4.01324365
23behavioral response to nicotine (GO:0035095)3.99613674
24viral transcription (GO:0019083)3.89561702
25regulation of mitochondrial translation (GO:0070129)3.85836457
26protein complex disassembly (GO:0043241)3.82437554
27GTP biosynthetic process (GO:0006183)3.79456146
28myelination (GO:0042552)3.79241929
29axon ensheathment (GO:0008366)3.74709893
30ensheathment of neurons (GO:0007272)3.74709893
31presynaptic membrane assembly (GO:0097105)3.70837328
32nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.68253899
33translational termination (GO:0006415)3.68227728
34cotranslational protein targeting to membrane (GO:0006613)3.67793008
35establishment of protein localization to mitochondrial membrane (GO:0090151)3.66201882
36macromolecular complex disassembly (GO:0032984)3.64575694
37GPI anchor biosynthetic process (GO:0006506)3.62262647
38hydrogen ion transmembrane transport (GO:1902600)3.60778188
39ribosomal large subunit biogenesis (GO:0042273)3.59162410
40protein-cofactor linkage (GO:0018065)3.57729407
41protein targeting to ER (GO:0045047)3.57499731
42presynaptic membrane organization (GO:0097090)3.56696097
43substantia nigra development (GO:0021762)3.54334162
44negative regulation of neurotransmitter transport (GO:0051589)3.54173077
45exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.53168813
46mitochondrial respiratory chain complex assembly (GO:0033108)3.51049510
47SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.50153389
48cholesterol biosynthetic process (GO:0006695)3.48487248
49establishment of protein localization to endoplasmic reticulum (GO:0072599)3.46060610
50protein localization to endoplasmic reticulum (GO:0070972)3.44892861
51platelet dense granule organization (GO:0060155)3.41091608
52DNA deamination (GO:0045006)3.40752104
53water-soluble vitamin biosynthetic process (GO:0042364)3.37345957
54proton transport (GO:0015992)3.34275865
55negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.31020182
56purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.27628874
57nuclear-transcribed mRNA catabolic process (GO:0000956)3.27405533
58hydrogen transport (GO:0006818)3.24819451
59isoprenoid biosynthetic process (GO:0008299)3.21917005
60dopamine biosynthetic process (GO:0042416)3.21686513
61pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.20717765
62GPI anchor metabolic process (GO:0006505)3.19374419
63neuron cell-cell adhesion (GO:0007158)3.19126735
64nucleoside triphosphate biosynthetic process (GO:0009142)3.18249387
65rRNA modification (GO:0000154)3.17461800
66purine nucleoside triphosphate biosynthetic process (GO:0009145)3.17428934
67cellular component biogenesis (GO:0044085)3.14589171
68preassembly of GPI anchor in ER membrane (GO:0016254)3.13974532
69ATP biosynthetic process (GO:0006754)3.12821082
70pseudouridine synthesis (GO:0001522)3.08586990
71sterol biosynthetic process (GO:0016126)3.08438660
72tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.08149146
73RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.08149146
74mRNA catabolic process (GO:0006402)3.07913798
75negative regulation of protein localization to cell surface (GO:2000009)3.05739627
76mitochondrial transport (GO:0006839)3.05024462
77regulation of dopamine metabolic process (GO:0042053)3.04465733
78regulation of catecholamine metabolic process (GO:0042069)3.04465733
79mannosylation (GO:0097502)3.03469989
80spliceosomal snRNP assembly (GO:0000387)3.02493062
81proteasome assembly (GO:0043248)3.00382702
82positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.99340037
83chromatin remodeling at centromere (GO:0031055)2.97909969
84dopamine transport (GO:0015872)2.97374381
85DNA damage response, detection of DNA damage (GO:0042769)2.97149461
86negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.96255926
87negative regulation of ligase activity (GO:0051352)2.96255926
88oxidative phosphorylation (GO:0006119)2.94773095
89cellular protein complex disassembly (GO:0043624)2.93784289
90transcription elongation from RNA polymerase III promoter (GO:0006385)2.93677538
91termination of RNA polymerase III transcription (GO:0006386)2.93677538
92DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.93189635
93regulation of cellular amino acid metabolic process (GO:0006521)2.92881394
94UTP biosynthetic process (GO:0006228)2.92541755
95regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.92259035
96negative regulation of neurotransmitter secretion (GO:0046929)2.90462187
97viral life cycle (GO:0019058)2.89233301
98CENP-A containing nucleosome assembly (GO:0034080)2.86632294
99spliceosomal complex assembly (GO:0000245)2.86555972
100signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.86495137
101signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.86495137
102signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.86495137
103response to redox state (GO:0051775)2.83804391
104inner mitochondrial membrane organization (GO:0007007)2.82390568
105purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.82174239
106purine nucleoside monophosphate biosynthetic process (GO:0009127)2.82174239
107signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.81469928
108intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.81469928
109RNA catabolic process (GO:0006401)2.80790614
110regulation of collateral sprouting (GO:0048670)2.80766860
111amyloid precursor protein metabolic process (GO:0042982)2.76604995
112ribonucleoside triphosphate biosynthetic process (GO:0009201)2.76100537
1137-methylguanosine mRNA capping (GO:0006370)2.75961679
114cellular response to epinephrine stimulus (GO:0071872)2.74728719
115ribosomal small subunit assembly (GO:0000028)2.74360334
116rRNA processing (GO:0006364)2.73732856
117anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.73036083
118deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.71646890
119signal transduction involved in DNA integrity checkpoint (GO:0072401)2.71174399
120signal transduction involved in DNA damage checkpoint (GO:0072422)2.71174399
121signal transduction involved in cell cycle checkpoint (GO:0072395)2.70023708
122neuronal action potential propagation (GO:0019227)2.69825206
1237-methylguanosine RNA capping (GO:0009452)2.69535976
124nucleotide transmembrane transport (GO:1901679)2.68979212
125translational elongation (GO:0006414)2.68309246
126oligodendrocyte differentiation (GO:0048709)2.68202537
127protein targeting to mitochondrion (GO:0006626)2.67986605
128neurotransmitter uptake (GO:0001504)2.65597285
129response to epinephrine (GO:0071871)2.65422138
130respiratory chain complex IV assembly (GO:0008535)2.61608411
131glycerophospholipid catabolic process (GO:0046475)2.56748081
132negative regulation of execution phase of apoptosis (GO:1900118)2.56402504
133negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.56075767
134glycolipid biosynthetic process (GO:0009247)2.53825186
135establishment of protein localization to mitochondrion (GO:0072655)2.52906067
136positive regulation of oligodendrocyte differentiation (GO:0048714)2.52577664
137UTP metabolic process (GO:0046051)2.50660245
138transmission of nerve impulse (GO:0019226)2.48649331
139C-terminal protein lipidation (GO:0006501)2.48106142
140eye photoreceptor cell differentiation (GO:0001754)2.48014136
141photoreceptor cell differentiation (GO:0046530)2.48014136
142neural nucleus development (GO:0048857)2.47972731
143positive regulation of action potential (GO:0045760)2.47797269
144translation (GO:0006412)2.46987042
145positive regulation of cellular amine metabolic process (GO:0033240)2.45853573
146energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.45766365
147ATP hydrolysis coupled proton transport (GO:0015991)2.45766365
148CTP metabolic process (GO:0046036)2.45206508
149CTP biosynthetic process (GO:0006241)2.45206508
150protein targeting to membrane (GO:0006612)2.44033125
151L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.40634799
152intracellular protein transmembrane import (GO:0044743)2.39771967
153gamma-aminobutyric acid signaling pathway (GO:0007214)2.39385892
154response to methylmercury (GO:0051597)2.35907344
155protein localization to mitochondrion (GO:0070585)2.35588525

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.07546295
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.57805652
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.12006414
4GBX2_23144817_ChIP-Seq_PC3_Human2.96223277
5EZH2_22144423_ChIP-Seq_EOC_Human2.93251619
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.84191250
7TAF15_26573619_Chip-Seq_HEK293_Human2.81726605
8VDR_22108803_ChIP-Seq_LS180_Human2.77062618
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.73253641
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.49564041
11VDR_23849224_ChIP-Seq_CD4+_Human2.48569930
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.46425038
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.45916011
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.38451651
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.35998573
16ZNF274_21170338_ChIP-Seq_K562_Hela2.22849358
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.14320767
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.13369953
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.08650918
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.02213565
21FOXP3_21729870_ChIP-Seq_TREG_Human2.02046097
22MYC_18940864_ChIP-ChIP_HL60_Human2.00861675
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00340438
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.99569031
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.95339729
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.91758822
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.85981623
28FUS_26573619_Chip-Seq_HEK293_Human1.85800119
29ELF1_17652178_ChIP-ChIP_JURKAT_Human1.84452567
30SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.82370070
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.81807676
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.77140008
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.75632605
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.75368765
35TTF2_22483619_ChIP-Seq_HELA_Human1.75368342
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.74552169
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74286311
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74060497
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.73020950
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.72879152
41ER_23166858_ChIP-Seq_MCF-7_Human1.69647349
42E2F4_17652178_ChIP-ChIP_JURKAT_Human1.68667697
43SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63054970
44SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.61441603
45JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.58443347
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.58019550
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54355041
48XRN2_22483619_ChIP-Seq_HELA_Human1.54108264
49P300_19829295_ChIP-Seq_ESCs_Human1.52195059
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.51233599
51MYC_19030024_ChIP-ChIP_MESCs_Mouse1.49241294
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.49238044
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43649845
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42333264
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42016827
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40900574
57DCP1A_22483619_ChIP-Seq_HELA_Human1.40122459
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39729318
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.39656198
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39061069
61E2F1_18555785_ChIP-Seq_MESCs_Mouse1.38309734
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.37660762
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37382159
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37196047
65RNF2_18974828_ChIP-Seq_MESCs_Mouse1.36245185
66EZH2_18974828_ChIP-Seq_MESCs_Mouse1.36245185
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.36007678
68EZH2_27294783_Chip-Seq_ESCs_Mouse1.35926904
69MTF2_20144788_ChIP-Seq_MESCs_Mouse1.31841388
70MYC_19079543_ChIP-ChIP_MESCs_Mouse1.31305088
71SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.30353670
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29087720
73TP53_22573176_ChIP-Seq_HFKS_Human1.27699638
74ETS1_20019798_ChIP-Seq_JURKAT_Human1.27591021
75GABP_19822575_ChIP-Seq_HepG2_Human1.25562481
76SOX2_16153702_ChIP-ChIP_HESCs_Human1.25235882
77FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.24939567
78RNF2_27304074_Chip-Seq_NSC_Mouse1.24519271
79CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23109423
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.22280485
81CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21644880
82FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19982952
83FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.19569119
84SRF_21415370_ChIP-Seq_HL-1_Mouse1.19006795
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.18889505
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18575285
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.17527894
88IGF1R_20145208_ChIP-Seq_DFB_Human1.17261411
89HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.17232609
90EWS_26573619_Chip-Seq_HEK293_Human1.17029796
91EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.16271926
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13854426
93RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13581562
94TAL1_26923725_Chip-Seq_HPCs_Mouse1.12280088
95TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11709744
96SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11622877
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.11616764
98P300_18555785_Chip-Seq_ESCs_Mouse1.10115117
99CMYC_18555785_Chip-Seq_ESCs_Mouse1.09381855
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08711709
101EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08389953
102AR_21572438_ChIP-Seq_LNCaP_Human1.05838051
103IRF1_19129219_ChIP-ChIP_H3396_Human1.05629569
104P53_22387025_ChIP-Seq_ESCs_Mouse1.05171718
105RNF2_27304074_Chip-Seq_ESCs_Mouse1.04341242
106FOXA1_25329375_ChIP-Seq_VCAP_Human1.03391738
107FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03391738
108ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02705932
109YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01927723
110MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.01877381
111RUNX1_27457419_Chip-Seq_LIVER_Mouse1.01692272
112STAT3_18555785_Chip-Seq_ESCs_Mouse1.01591295
113PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01198483
114POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99209645
115TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98504213
116ELK1_19687146_ChIP-ChIP_HELA_Human0.98297259
117PIAS1_25552417_ChIP-Seq_VCAP_Human0.98149821
118ERG_20517297_ChIP-Seq_VCAP_Human0.97927711
119SOX2_19829295_ChIP-Seq_ESCs_Human0.97621560
120SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97594037
121REST_21632747_ChIP-Seq_MESCs_Mouse0.97203645
122EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97150591
123SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96904919
124E2F1_18555785_Chip-Seq_ESCs_Mouse0.96771282
125CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94906710
126SOX2_18555785_Chip-Seq_ESCs_Mouse0.94015909
127AR_20517297_ChIP-Seq_VCAP_Human0.93193646
128SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93148539
129FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92952167
130EZH2_27294783_Chip-Seq_NPCs_Mouse0.92188155
131IKZF1_21737484_ChIP-ChIP_HCT116_Human0.92051984
132NOTCH1_21737748_ChIP-Seq_TLL_Human0.92051111
133HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.91820290
134SMAD1_18555785_Chip-Seq_ESCs_Mouse0.91649703
135KLF4_18555785_Chip-Seq_ESCs_Mouse0.91508489
136TP63_19390658_ChIP-ChIP_HaCaT_Human0.91394407
137HTT_18923047_ChIP-ChIP_STHdh_Human0.90835941
138GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90615792
139ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90171124
140NMYC_18555785_Chip-Seq_ESCs_Mouse0.89952903
141MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89865637
142JUN_21703547_ChIP-Seq_K562_Human0.89725243
143ELK1_22589737_ChIP-Seq_MCF10A_Human0.89615370
144NCOR_22424771_ChIP-Seq_293T_Human0.89222773
145NANOG_16153702_ChIP-ChIP_HESCs_Human0.88976035
146NANOG_19829295_ChIP-Seq_ESCs_Human0.88889848
147FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85085506
148GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.82741282
149CTCF_18555785_ChIP-Seq_MESCs_Mouse0.81708422
150GATA3_21878914_ChIP-Seq_MCF-7_Human0.81404424
151PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.81276220
152CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.79461808
153PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78578805
154NELFA_20434984_ChIP-Seq_ESCs_Mouse0.78300777

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.78831166
2MP0009379_abnormal_foot_pigmentation3.71905407
3MP0003136_yellow_coat_color3.57117432
4MP0001529_abnormal_vocalization3.43425816
5MP0001905_abnormal_dopamine_level3.20933327
6MP0000920_abnormal_myelination3.20844427
7MP0005409_darkened_coat_color2.53683446
8MP0005171_absent_coat_pigmentation2.44294331
9MP0002272_abnormal_nervous_system2.32163575
10MP0004142_abnormal_muscle_tone2.30308161
11MP0004381_abnormal_hair_follicle2.20129564
12MP0005423_abnormal_somatic_nervous2.14151061
13MP0002064_seizures2.06479929
14MP0004270_analgesia2.02725544
15MP0001188_hyperpigmentation2.01694329
16MP0004742_abnormal_vestibular_system2.01466850
17MP0009745_abnormal_behavioral_response1.97094717
18MP0001486_abnormal_startle_reflex1.93953504
19MP0009046_muscle_twitch1.90382641
20MP0001968_abnormal_touch/_nociception1.89390745
21MP0002736_abnormal_nociception_after1.86915380
22MP0006276_abnormal_autonomic_nervous1.85486481
23MP0005084_abnormal_gallbladder_morpholo1.81324466
24MP0001986_abnormal_taste_sensitivity1.78015569
25MP0008877_abnormal_DNA_methylation1.76983411
26MP0003950_abnormal_plasma_membrane1.75107212
27MP0008789_abnormal_olfactory_epithelium1.72044698
28MP0002653_abnormal_ependyma_morphology1.70883045
29MP0001440_abnormal_grooming_behavior1.68974443
30MP0005551_abnormal_eye_electrophysiolog1.68554412
31MP0005645_abnormal_hypothalamus_physiol1.67217560
32MP0002734_abnormal_mechanical_nocicepti1.66574609
33MP0008058_abnormal_DNA_repair1.66560027
34MP0003806_abnormal_nucleotide_metabolis1.66085301
35MP0000372_irregular_coat_pigmentation1.64628995
36MP0005646_abnormal_pituitary_gland1.63349768
37MP0001485_abnormal_pinna_reflex1.63208426
38MP0004133_heterotaxia1.62138998
39MP0002163_abnormal_gland_morphology1.61220286
40MP0003635_abnormal_synaptic_transmissio1.59482110
41MP0002572_abnormal_emotion/affect_behav1.55574714
42MP0000778_abnormal_nervous_system1.55329745
43MP0005451_abnormal_body_composition1.53622094
44MP0008995_early_reproductive_senescence1.53397955
45MP0005379_endocrine/exocrine_gland_phen1.50503752
46MP0005410_abnormal_fertilization1.48713131
47MP0003690_abnormal_glial_cell1.48081391
48MP0002067_abnormal_sensory_capabilities1.43830463
49MP0001501_abnormal_sleep_pattern1.40234765
50MP0003011_delayed_dark_adaptation1.39227797
51MP0008875_abnormal_xenobiotic_pharmacok1.38544109
52MP0001984_abnormal_olfaction1.38220651
53MP0001970_abnormal_pain_threshold1.37741272
54MP0003718_maternal_effect1.36680901
55MP0001293_anophthalmia1.35643130
56MP0002229_neurodegeneration1.34457823
57MP0002638_abnormal_pupillary_reflex1.33965150
58MP0003787_abnormal_imprinting1.32382644
59MP0006035_abnormal_mitochondrial_morpho1.30935325
60MP0008872_abnormal_physiological_respon1.25040804
61MP0002735_abnormal_chemical_nociception1.24684537
62MP0005386_behavior/neurological_phenoty1.24368173
63MP0004924_abnormal_behavior1.24368173
64MP0002063_abnormal_learning/memory/cond1.24071218
65MP0002733_abnormal_thermal_nociception1.23154803
66MP0005499_abnormal_olfactory_system1.23079033
67MP0005394_taste/olfaction_phenotype1.23079033
68MP0002095_abnormal_skin_pigmentation1.22084046
69MP0003786_premature_aging1.21310739
70MP0003121_genomic_imprinting1.19376496
71MP0003634_abnormal_glial_cell1.19104470
72MP0004859_abnormal_synaptic_plasticity1.16296700
73MP0002148_abnormal_hypersensitivity_rea1.15948558
74MP0001963_abnormal_hearing_physiology1.12479729
75MP0003329_amyloid_beta_deposits1.11956591
76MP0006292_abnormal_olfactory_placode1.11773272
77MP0002277_abnormal_respiratory_mucosa1.10659705
78MP0010386_abnormal_urinary_bladder1.10590390
79MP0010030_abnormal_orbit_morphology1.10414597
80MP0002752_abnormal_somatic_nervous1.09265232
81MP0002234_abnormal_pharynx_morphology1.07100349
82MP0002751_abnormal_autonomic_nervous1.06984865
83MP0004145_abnormal_muscle_electrophysio1.04330148
84MP0004147_increased_porphyrin_level1.04317379
85MP0003122_maternal_imprinting1.03127128
86MP0005389_reproductive_system_phenotype1.03093173
87MP0000026_abnormal_inner_ear1.00614877
88MP0003724_increased_susceptibility_to1.00493999
89MP0001727_abnormal_embryo_implantation1.00204148
90MP0002882_abnormal_neuron_morphology1.00132395
91MP0001346_abnormal_lacrimal_gland0.99998813
92MP0003938_abnormal_ear_development0.99869527
93MP0001764_abnormal_homeostasis0.98171711
94MP0002066_abnormal_motor_capabilities/c0.97949530
95MP0001919_abnormal_reproductive_system0.97678949
96MP0005253_abnormal_eye_physiology0.97207050
97MP0003195_calcinosis0.96850537
98MP0000049_abnormal_middle_ear0.96543905
99MP0002184_abnormal_innervation0.94095058
100MP0002837_dystrophic_cardiac_calcinosis0.93273336
101MP0006072_abnormal_retinal_apoptosis0.91048106
102MP0003283_abnormal_digestive_organ0.88358456
103MP0002160_abnormal_reproductive_system0.88207925
104MP0003632_abnormal_nervous_system0.88036559
105MP0005195_abnormal_posterior_eye0.87235689
106MP0002876_abnormal_thyroid_physiology0.86893971
107MP0000566_synostosis0.86404087
108MP0002557_abnormal_social/conspecific_i0.85358044
109MP0002210_abnormal_sex_determination0.84325129
110MP0000955_abnormal_spinal_cord0.84263234
111MP0002102_abnormal_ear_morphology0.84167368
112MP0005671_abnormal_response_to0.83441106
113MP0002822_catalepsy0.83274415
114MP0004019_abnormal_vitamin_homeostasis0.83177223
115MP0001664_abnormal_digestion0.82916546
116MP0003631_nervous_system_phenotype0.82821311
117MP0005408_hypopigmentation0.79841821
118MP0004885_abnormal_endolymph0.79733682
119MP0000569_abnormal_digit_pigmentation0.79717726
120MP0006082_CNS_inflammation0.77780250
121MP0005075_abnormal_melanosome_morpholog0.76756878
122MP0002282_abnormal_trachea_morphology0.76630318
123MP0006036_abnormal_mitochondrial_physio0.76081751
124MP0008569_lethality_at_weaning0.75734682
125MP0005391_vision/eye_phenotype0.73471330
126MP0003878_abnormal_ear_physiology0.73467569
127MP0005377_hearing/vestibular/ear_phenot0.73467569
128MP0003315_abnormal_perineum_morphology0.73160872
129MP0000631_abnormal_neuroendocrine_gland0.72729957
130MP0002090_abnormal_vision0.72703184
131MP0004043_abnormal_pH_regulation0.72520528
132MP0000015_abnormal_ear_pigmentation0.71575230
133MP0005174_abnormal_tail_pigmentation0.70870675
134MP0004957_abnormal_blastocyst_morpholog0.70425281
135MP0003633_abnormal_nervous_system0.69765736
136MP0004134_abnormal_chest_morphology0.69171183
137MP0002938_white_spotting0.68547726
138MP0008004_abnormal_stomach_pH0.65106819
139MP0001851_eye_inflammation0.63921968
140MP0001502_abnormal_circadian_rhythm0.63723698
141MP0003186_abnormal_redox_activity0.63713788

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.88427034
2Parakeratosis (HP:0001036)5.32778044
3Abnormal mitochondria in muscle tissue (HP:0008316)5.02679250
4* Mitochondrial inheritance (HP:0001427)4.99532386
5Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.97180357
6Progressive macrocephaly (HP:0004481)4.96566564
7Acute encephalopathy (HP:0006846)4.71191197
8Hepatocellular necrosis (HP:0001404)4.28125912
9* Increased CSF lactate (HP:0002490)3.95635637
103-Methylglutaconic aciduria (HP:0003535)3.84902900
11Leukodystrophy (HP:0002415)3.67043242
12* Renal Fanconi syndrome (HP:0001994)3.65828113
13Optic disc pallor (HP:0000543)3.60183750
14Congenital, generalized hypertrichosis (HP:0004540)3.50660777
15Abnormality of glycolysis (HP:0004366)3.49015003
16Increased serum pyruvate (HP:0003542)3.49015003
17* Increased hepatocellular lipid droplets (HP:0006565)3.48669362
18Congenital ichthyosiform erythroderma (HP:0007431)3.44748416
19Hepatic necrosis (HP:0002605)3.43135294
20Sensory axonal neuropathy (HP:0003390)3.34901035
21Pancreatic cysts (HP:0001737)3.32941426
22Pancreatic fibrosis (HP:0100732)3.26419756
23Molar tooth sign on MRI (HP:0002419)3.13003537
24Abnormality of midbrain morphology (HP:0002418)3.13003537
25True hermaphroditism (HP:0010459)3.10562091
26Respiratory failure (HP:0002878)3.08979877
27* Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.02716319
28* Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.98875209
29Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.98320898
30Degeneration of the lateral corticospinal tracts (HP:0002314)2.98320898
31Cerebral edema (HP:0002181)2.97121725
32Neurofibrillary tangles (HP:0002185)2.96795849
33* Lipid accumulation in hepatocytes (HP:0006561)2.95777917
34Abnormality of cells of the erythroid lineage (HP:0012130)2.91078288
35Retinal dysplasia (HP:0007973)2.74390519
36Nephronophthisis (HP:0000090)2.68417990
37Peripheral hypomyelination (HP:0007182)2.64610530
38* Exercise intolerance (HP:0003546)2.57355493
39Abnormal number of erythroid precursors (HP:0012131)2.52061420
40Aplastic anemia (HP:0001915)2.47410795
41Dynein arm defect of respiratory motile cilia (HP:0012255)2.47100190
42Absent/shortened dynein arms (HP:0200106)2.47100190
43Focal motor seizures (HP:0011153)2.46500228
44* Abnormality of renal resorption (HP:0011038)2.46179625
45Macrocytic anemia (HP:0001972)2.45089405
46Generalized aminoaciduria (HP:0002909)2.43831840
47* Lactic acidosis (HP:0003128)2.43482376
48Cerebral hypomyelination (HP:0006808)2.42256422
49Hypothermia (HP:0002045)2.41956464
50Decreased activity of mitochondrial respiratory chain (HP:0008972)2.40785877
51Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.40785877
52Lethargy (HP:0001254)2.37912610
53Septo-optic dysplasia (HP:0100842)2.36729626
54* Increased serum lactate (HP:0002151)2.35962432
55Patchy hypopigmentation of hair (HP:0011365)2.32753511
56Methylmalonic aciduria (HP:0012120)2.31756547
57Sclerocornea (HP:0000647)2.30388265
58Medial flaring of the eyebrow (HP:0010747)2.27966898
59* Increased intramyocellular lipid droplets (HP:0012240)2.27204441
60X-linked dominant inheritance (HP:0001423)2.26787709
61Pendular nystagmus (HP:0012043)2.24127275
62Reticulocytopenia (HP:0001896)2.22259985
63Abnormality of placental membranes (HP:0011409)2.19276781
64Amniotic constriction ring (HP:0009775)2.19276781
65Congenital stationary night blindness (HP:0007642)2.15902074
66Abnormality of secondary sexual hair (HP:0009888)2.14225615
67Abnormality of the axillary hair (HP:0100134)2.14225615
68White forelock (HP:0002211)2.13756385
69Oral leukoplakia (HP:0002745)2.13298263
70* Exertional dyspnea (HP:0002875)2.11955397
71Colon cancer (HP:0003003)2.11772704
72Myokymia (HP:0002411)2.07902134
73Abnormality of the renal medulla (HP:0100957)2.07405740
74Abnormal ciliary motility (HP:0012262)2.04126034
75Concave nail (HP:0001598)2.02883505
76Abnormal pupillary function (HP:0007686)2.02711181
77Cerebral inclusion bodies (HP:0100314)2.01861459
78Aplasia/Hypoplasia of the sacrum (HP:0008517)2.01806689
79Abnormality of the labia minora (HP:0012880)2.00658968
80Spastic paraparesis (HP:0002313)1.99595439
81Methylmalonic acidemia (HP:0002912)1.98179099
82Male pseudohermaphroditism (HP:0000037)1.97959284
83Cerebral hemorrhage (HP:0001342)1.97902312
84Abnormal respiratory motile cilium morphology (HP:0005938)1.97847494
85Abnormal respiratory epithelium morphology (HP:0012253)1.97847494
86Anencephaly (HP:0002323)1.96991870
87Type I transferrin isoform profile (HP:0003642)1.95000250
88Erythroderma (HP:0001019)1.93431426
89* Abnormality of urine glucose concentration (HP:0011016)1.91196092
90* Glycosuria (HP:0003076)1.91196092
91Absent septum pellucidum (HP:0001331)1.90590502
92Absent rod-and cone-mediated responses on ERG (HP:0007688)1.90152029
93Neuroendocrine neoplasm (HP:0100634)1.89904593
94Vaginal atresia (HP:0000148)1.89748630
95CNS demyelination (HP:0007305)1.89053838
96Abnormality of the septum pellucidum (HP:0007375)1.89025058
97Gait imbalance (HP:0002141)1.87271733
98Abnormal hair whorl (HP:0010721)1.86499966
99Hepatosplenomegaly (HP:0001433)1.86293408
100Pancytopenia (HP:0001876)1.86183838
101Abnormal rod and cone electroretinograms (HP:0008323)1.85666591
102Hypoplastic pelvis (HP:0008839)1.85011959
103Genital tract atresia (HP:0001827)1.83756596
104Congenital primary aphakia (HP:0007707)1.83487467
105Hyperventilation (HP:0002883)1.82880928
106Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.81651476
107Cystic liver disease (HP:0006706)1.81554011
108Hyperglycinemia (HP:0002154)1.80636817
109Septate vagina (HP:0001153)1.79410912
110Epileptic encephalopathy (HP:0200134)1.77799650
111Pallor (HP:0000980)1.76298330
112Pheochromocytoma (HP:0002666)1.76255873
113Aplasia/Hypoplasia of the tongue (HP:0010295)1.76227052
114Congenital sensorineural hearing impairment (HP:0008527)1.76143467
115Aplasia/hypoplasia of the uterus (HP:0008684)1.74729730
116Limb dystonia (HP:0002451)1.74264225
117Abnormality of the corticospinal tract (HP:0002492)1.74260254
118Emotional lability (HP:0000712)1.74085026
119Autoamputation (HP:0001218)1.72786629
120Rhinitis (HP:0012384)1.71586950
121Blindness (HP:0000618)1.70998541
122Abnormality of the renal cortex (HP:0011035)1.70679580
123Abolished electroretinogram (ERG) (HP:0000550)1.70517032
124* Increased muscle lipid content (HP:0009058)1.70514372
125Delusions (HP:0000746)1.69503605
126Split foot (HP:0001839)1.68022783
127Nephrogenic diabetes insipidus (HP:0009806)1.67076972
128Degeneration of anterior horn cells (HP:0002398)1.66642983
129Abnormality of the anterior horn cell (HP:0006802)1.66642983
130Hypoplasia of the pons (HP:0012110)1.66615221
131Optic nerve hypoplasia (HP:0000609)1.65599651
132Abnormal hemoglobin (HP:0011902)1.65375433
133Abnormality of the pons (HP:0007361)1.65238114
134Atonic seizures (HP:0010819)1.64924788
135Progressive inability to walk (HP:0002505)1.64862273
136Broad-based gait (HP:0002136)1.64408605
137Furrowed tongue (HP:0000221)1.64075816
138Absent thumb (HP:0009777)1.63337091
139Abnormal respiratory motile cilium physiology (HP:0012261)1.63035182
140Type II lissencephaly (HP:0007260)1.62773307
141Dicarboxylic aciduria (HP:0003215)1.62422691
142Abnormality of dicarboxylic acid metabolism (HP:0010995)1.62422691
143Rib fusion (HP:0000902)1.61894361
144CNS hypomyelination (HP:0003429)1.61816623
145Hypomagnesemia (HP:0002917)1.61393850
146Hypoplastic left heart (HP:0004383)1.59634294

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.92524863
2STK394.23303239
3ZAK3.18819807
4PBK3.09659293
5OXSR13.02095650
6CASK2.83101207
7CDK192.50156694
8TLK12.43854313
9TNIK2.40302485
10WNK32.34022401
11MST42.32637774
12STK162.31396587
13ARAF2.19405326
14BCR2.12804073
15PNCK2.11128453
16NME12.02063467
17MAPKAPK51.99163016
18BMPR1B1.93950798
19MAP4K21.92779728
20MAP3K121.92358346
21NME21.88236595
22WNK41.81789235
23BCKDK1.81522717
24CDC71.78248064
25GRK71.74947898
26MUSK1.73481766
27PKN11.65031001
28RIPK41.59357160
29BMPR21.54853130
30FGR1.52865668
31TAF11.39439884
32CSNK1G31.32154398
33EPHA41.29602024
34DYRK31.28029387
35CAMK2B1.27295721
36FRK1.24363526
37EPHB11.23087854
38PLK31.21665576
39GRK51.21157397
40BLK1.21006094
41UHMK11.20718812
42ADRBK21.19791843
43INSRR1.18762742
44TAOK31.17265945
45NEK61.14162516
46MAP3K41.13057778
47TESK21.10426517
48ROCK21.07274735
49CAMK2D1.06743237
50PLK41.02382725
51LIMK10.98873651
52FES0.97215858
53PIM20.96933673
54PINK10.96412925
55CSNK1G10.95916786
56PASK0.93446303
57IRAK40.91759010
58VRK10.91753435
59CAMK2A0.91325167
60WNK10.90400480
61PRKCG0.88990496
62MYLK0.87762333
63MAP2K70.86741945
64NUAK10.85993782
65KDR0.84456535
66CSNK1A1L0.82878786
67MKNK10.81963239
68IRAK20.81507351
69WEE10.81339056
70CLK10.80843701
71CSNK1G20.80714315
72SRPK10.79837764
73MET0.78908215
74CAMK2G0.78076877
75BRAF0.78040622
76PRKCQ0.76888136
77PRKCE0.76543845
78PLK10.76279475
79RPS6KA50.74749097
80IRAK10.73190934
81MKNK20.71511430
82DYRK20.71432181
83PRPF4B0.70272209
84MAPK130.67279574
85CSNK2A20.66949326
86PAK30.66872420
87TRIM280.66810828
88EPHB20.65477936
89NTRK10.65327702
90AURKB0.64670896
91CSNK2A10.63806849
92BRSK20.61262923
93MAP3K110.60785335
94AURKA0.59938304
95GRK10.59858197
96CCNB10.59776338
97PLK20.58764352
98PHKG20.58571263
99PHKG10.58571263
100ACVR1B0.58501475
101MAPK150.57621165
102CHEK20.56753488
103MINK10.54713572
104TTK0.53920331
105CDK140.53770210
106TIE10.53212707
107ABL20.53071802
108DAPK30.52815837
109YES10.52323896
110TGFBR10.51948344
111NEK10.51088603
112CDK50.50873981
113NTRK20.50617730
114ADRBK10.50510905
115EIF2AK10.49465006
116LRRK20.49025065
117PTK2B0.48931919
118MAP3K130.48344760
119TNK20.47442405
120ATR0.47356625
121PRKG10.46437439
122LYN0.46159714
123KIT0.44973140
124BUB10.44762027
125CDK11A0.44711174
126PRKACA0.43947788
127MARK10.42643648
128SYK0.41932216
129STK40.41903698
130CDK180.41870089
131FGFR20.41649926
132CDK80.41173676
133CDK150.41154402
134OBSCN0.38647631
135DYRK1A0.38512040
136IRAK30.38444930
137EIF2AK30.38139028
138PDK20.37029058
139NEK20.36503447
140MOS0.36501965
141MAP3K140.36293368
142CDK30.35624808
143CSNK1E0.34882888
144TXK0.34456326
145LCK0.34400028
146SIK30.33295223
147IKBKB0.33146988
148FYN0.32817075
149CSNK1A10.32562122

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.57248392
2Parkinsons disease_Homo sapiens_hsa050124.46459817
3Ribosome_Homo sapiens_hsa030103.89357882
4Alzheimers disease_Homo sapiens_hsa050103.67659000
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.48019639
6Protein export_Homo sapiens_hsa030603.26404173
7Huntingtons disease_Homo sapiens_hsa050163.07060075
8Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.81739831
9Fatty acid elongation_Homo sapiens_hsa000622.72833677
10Proteasome_Homo sapiens_hsa030502.59699163
11Steroid biosynthesis_Homo sapiens_hsa001002.39742880
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.29935823
13Cardiac muscle contraction_Homo sapiens_hsa042602.15316131
14RNA polymerase_Homo sapiens_hsa030202.08487342
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.05751341
16Collecting duct acid secretion_Homo sapiens_hsa049661.93183554
17Ether lipid metabolism_Homo sapiens_hsa005651.74211271
18Mismatch repair_Homo sapiens_hsa034301.69172785
19DNA replication_Homo sapiens_hsa030301.47676493
20Sphingolipid metabolism_Homo sapiens_hsa006001.46467177
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.43441754
22Serotonergic synapse_Homo sapiens_hsa047261.42232574
23Nicotine addiction_Homo sapiens_hsa050331.36142549
24Rheumatoid arthritis_Homo sapiens_hsa053231.35222965
25SNARE interactions in vesicular transport_Homo sapiens_hsa041301.31036418
26Vibrio cholerae infection_Homo sapiens_hsa051101.30250692
27RNA degradation_Homo sapiens_hsa030181.28304925
28Phototransduction_Homo sapiens_hsa047441.24544294
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.15459015
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13620023
31Fanconi anemia pathway_Homo sapiens_hsa034601.10812157
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09383339
33Sulfur metabolism_Homo sapiens_hsa009201.07185184
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.04593456
35Base excision repair_Homo sapiens_hsa034101.02363611
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.01618834
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01181665
38Arachidonic acid metabolism_Homo sapiens_hsa005901.00939231
39Linoleic acid metabolism_Homo sapiens_hsa005910.99853964
40GABAergic synapse_Homo sapiens_hsa047270.99147744
41Histidine metabolism_Homo sapiens_hsa003400.98817371
42Glutamatergic synapse_Homo sapiens_hsa047240.93135700
43Morphine addiction_Homo sapiens_hsa050320.92994735
44Nitrogen metabolism_Homo sapiens_hsa009100.90327732
45One carbon pool by folate_Homo sapiens_hsa006700.89402688
46Autoimmune thyroid disease_Homo sapiens_hsa053200.87535993
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85336268
48Tryptophan metabolism_Homo sapiens_hsa003800.82303573
49Caffeine metabolism_Homo sapiens_hsa002320.82247372
50Propanoate metabolism_Homo sapiens_hsa006400.81105692
51Graft-versus-host disease_Homo sapiens_hsa053320.78039253
52Taste transduction_Homo sapiens_hsa047420.77689285
53Long-term depression_Homo sapiens_hsa047300.77495859
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76233013
55Synaptic vesicle cycle_Homo sapiens_hsa047210.76056245
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75778520
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75003965
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74436949
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.74125972
60Basal transcription factors_Homo sapiens_hsa030220.73901851
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73581951
62RNA transport_Homo sapiens_hsa030130.72414419
63Metabolic pathways_Homo sapiens_hsa011000.71455435
64Glutathione metabolism_Homo sapiens_hsa004800.68374345
65Axon guidance_Homo sapiens_hsa043600.67620333
66Allograft rejection_Homo sapiens_hsa053300.67612108
67Phagosome_Homo sapiens_hsa041450.66894273
68Pyrimidine metabolism_Homo sapiens_hsa002400.65644826
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63056666
70Pyruvate metabolism_Homo sapiens_hsa006200.62112212
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61496335
72Circadian entrainment_Homo sapiens_hsa047130.60572513
73Systemic lupus erythematosus_Homo sapiens_hsa053220.59938047
74Asthma_Homo sapiens_hsa053100.59878817
75Homologous recombination_Homo sapiens_hsa034400.59749540
76Purine metabolism_Homo sapiens_hsa002300.56262345
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.55533188
78Selenocompound metabolism_Homo sapiens_hsa004500.52418981
79Salivary secretion_Homo sapiens_hsa049700.51119497
80African trypanosomiasis_Homo sapiens_hsa051430.50089786
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48757155
82Primary immunodeficiency_Homo sapiens_hsa053400.48341423
83Tyrosine metabolism_Homo sapiens_hsa003500.47762868
84Type I diabetes mellitus_Homo sapiens_hsa049400.47537058
85Dopaminergic synapse_Homo sapiens_hsa047280.47148294
86Arginine and proline metabolism_Homo sapiens_hsa003300.46248050
87Retinol metabolism_Homo sapiens_hsa008300.45372316
88Renin secretion_Homo sapiens_hsa049240.43120232
89Regulation of autophagy_Homo sapiens_hsa041400.42055558
90Malaria_Homo sapiens_hsa051440.41480850
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.41466213
92Amphetamine addiction_Homo sapiens_hsa050310.39462893
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37670060
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37636240
95Cocaine addiction_Homo sapiens_hsa050300.37608050
96Calcium signaling pathway_Homo sapiens_hsa040200.36942923
97Cholinergic synapse_Homo sapiens_hsa047250.36278042
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.35879595
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35671480
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34741337
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.33251983
102Vitamin digestion and absorption_Homo sapiens_hsa049770.33167208
103Butanoate metabolism_Homo sapiens_hsa006500.33074192
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33043014
105Basal cell carcinoma_Homo sapiens_hsa052170.31908521
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30638383
107Non-homologous end-joining_Homo sapiens_hsa034500.30471075
108beta-Alanine metabolism_Homo sapiens_hsa004100.29098728
109Alcoholism_Homo sapiens_hsa050340.28959302
110Spliceosome_Homo sapiens_hsa030400.28117233
111Folate biosynthesis_Homo sapiens_hsa007900.27843978
112Chemical carcinogenesis_Homo sapiens_hsa052040.26015775
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.25634396
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.25272475
115Drug metabolism - other enzymes_Homo sapiens_hsa009830.24603937
116Ras signaling pathway_Homo sapiens_hsa040140.24285099
117Peroxisome_Homo sapiens_hsa041460.24251072
118Phenylalanine metabolism_Homo sapiens_hsa003600.23950561
119Mineral absorption_Homo sapiens_hsa049780.23696113
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.23078427
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22553275
122Nucleotide excision repair_Homo sapiens_hsa034200.20191279
123Sulfur relay system_Homo sapiens_hsa041220.19895662
124Antigen processing and presentation_Homo sapiens_hsa046120.19652308
125Salmonella infection_Homo sapiens_hsa051320.19036704
126Long-term potentiation_Homo sapiens_hsa047200.18982448
127Fat digestion and absorption_Homo sapiens_hsa049750.18738935
128Epstein-Barr virus infection_Homo sapiens_hsa051690.18646192
129Other glycan degradation_Homo sapiens_hsa005110.16878750
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.16633317
131Pancreatic secretion_Homo sapiens_hsa049720.16239182
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.16228476
133Gastric acid secretion_Homo sapiens_hsa049710.15974949
134Intestinal immune network for IgA production_Homo sapiens_hsa046720.14776242
135Olfactory transduction_Homo sapiens_hsa047400.14320390

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