PET117

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.93435578
2DNA deamination (GO:0045006)6.19918702
3ribosomal small subunit biogenesis (GO:0042274)5.58573598
4viral transcription (GO:0019083)5.13055669
5translational termination (GO:0006415)4.97694757
6maturation of SSU-rRNA (GO:0030490)4.94410992
7proteasome assembly (GO:0043248)4.66145225
8kinetochore organization (GO:0051383)4.63448558
9telomere maintenance via semi-conservative replication (GO:0032201)4.62912481
10DNA replication initiation (GO:0006270)4.55755613
11kinetochore assembly (GO:0051382)4.39511380
12pseudouridine synthesis (GO:0001522)4.29943284
13translational elongation (GO:0006414)4.27550962
14formation of translation preinitiation complex (GO:0001731)4.18328696
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.17107575
16regulation of mitochondrial translation (GO:0070129)4.14236899
17DNA strand elongation involved in DNA replication (GO:0006271)4.14122793
18respiratory chain complex IV assembly (GO:0008535)4.08701151
19translational initiation (GO:0006413)4.08057524
20ribosomal large subunit biogenesis (GO:0042273)4.06821810
21protein targeting to ER (GO:0045047)4.04883363
22DNA double-strand break processing (GO:0000729)4.04280258
23cotranslational protein targeting to membrane (GO:0006613)4.04202834
24ribosome assembly (GO:0042255)4.03739800
25mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.02608140
26chaperone-mediated protein transport (GO:0072321)3.99914301
27ribonucleoprotein complex biogenesis (GO:0022613)3.99875432
28nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.99411098
29telomere maintenance via recombination (GO:0000722)3.97615917
30DNA strand elongation (GO:0022616)3.90686363
31meiotic chromosome segregation (GO:0045132)3.87829477
32establishment of integrated proviral latency (GO:0075713)3.84367522
33establishment of protein localization to endoplasmic reticulum (GO:0072599)3.83554302
34negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.82975115
35viral life cycle (GO:0019058)3.82351593
36establishment of protein localization to mitochondrial membrane (GO:0090151)3.80021847
37maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.79051068
38cellular protein complex disassembly (GO:0043624)3.78525600
39rRNA modification (GO:0000154)3.76513117
40regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.76223020
41protein localization to endoplasmic reticulum (GO:0070972)3.74188424
42poly(A)+ mRNA export from nucleus (GO:0016973)3.70986641
43mitotic recombination (GO:0006312)3.70352137
44protein complex biogenesis (GO:0070271)3.68375271
45positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.68276025
46mitochondrial respiratory chain complex assembly (GO:0033108)3.64938477
47telomere maintenance via telomere lengthening (GO:0010833)3.63704516
48purine nucleobase biosynthetic process (GO:0009113)3.60458440
49replication fork processing (GO:0031297)3.57857078
50CENP-A containing nucleosome assembly (GO:0034080)3.57695203
51chromatin remodeling at centromere (GO:0031055)3.56842687
52DNA replication checkpoint (GO:0000076)3.56122131
53mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.54517477
54regulation of cellular amino acid metabolic process (GO:0006521)3.54371692
55transcription elongation from RNA polymerase III promoter (GO:0006385)3.51594728
56termination of RNA polymerase III transcription (GO:0006386)3.51594728
57anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.51281253
58DNA catabolic process, exonucleolytic (GO:0000738)3.50835482
59GDP-mannose metabolic process (GO:0019673)3.50477400
60cytochrome complex assembly (GO:0017004)3.48980374
61regulation of helicase activity (GO:0051095)3.48889840
62deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.48511607
63spliceosomal snRNP assembly (GO:0000387)3.48393815
64nucleotide-excision repair, DNA gap filling (GO:0006297)3.46897223
65cullin deneddylation (GO:0010388)3.46677012
66negative regulation of ligase activity (GO:0051352)3.44498352
67negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.44498352
68protein complex disassembly (GO:0043241)3.43843711
69ribosome biogenesis (GO:0042254)3.41998839
70regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.41554582
71regulation of nuclear cell cycle DNA replication (GO:0033262)3.40231945
72mitochondrial respiratory chain complex I assembly (GO:0032981)3.39599874
73NADH dehydrogenase complex assembly (GO:0010257)3.39599874
74mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.39599874
75rRNA processing (GO:0006364)3.36776198
76DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.34021753
77rRNA methylation (GO:0031167)3.31843036
78signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.31769822
79signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.31769822
80signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.31769822
81macromolecular complex disassembly (GO:0032984)3.30045929
82ATP synthesis coupled proton transport (GO:0015986)3.29879821
83energy coupled proton transport, down electrochemical gradient (GO:0015985)3.29879821
84rRNA metabolic process (GO:0016072)3.29541343
85intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.28628636
86signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.28628636
87protein targeting to mitochondrion (GO:0006626)3.28015653
88protein deneddylation (GO:0000338)3.27227427
89proline biosynthetic process (GO:0006561)3.24961204
90tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.22381261
91RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.22381261
92regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.20859262
93signal transduction involved in DNA integrity checkpoint (GO:0072401)3.20519244
94signal transduction involved in DNA damage checkpoint (GO:0072422)3.20519244
95positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.19615055
96signal transduction involved in cell cycle checkpoint (GO:0072395)3.18103936
97translation (GO:0006412)3.17412605
98nucleobase biosynthetic process (GO:0046112)3.17306214
99IMP metabolic process (GO:0046040)3.15747679
100negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.15374557
101oxidative phosphorylation (GO:0006119)3.15102250
102L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.14837109
103negative regulation of transcription by competitive promoter binding (GO:0010944)3.14749226
104respiratory electron transport chain (GO:0022904)3.13761290
105nuclear-transcribed mRNA catabolic process (GO:0000956)3.13366780
106DNA unwinding involved in DNA replication (GO:0006268)3.11749502
107establishment of viral latency (GO:0019043)3.11298765
108somatic diversification of immune receptors via somatic mutation (GO:0002566)3.08500612
109somatic hypermutation of immunoglobulin genes (GO:0016446)3.08500612
110pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.06833267
111regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.06513944
112protein neddylation (GO:0045116)3.06351209
113protein localization to kinetochore (GO:0034501)3.05825201
114establishment of protein localization to mitochondrion (GO:0072655)3.05171515
115positive regulation of ligase activity (GO:0051351)3.04688562
116electron transport chain (GO:0022900)3.04590859
117DNA damage response, detection of DNA damage (GO:0042769)3.03428410
118IMP biosynthetic process (GO:0006188)3.02868179
119transcription from mitochondrial promoter (GO:0006390)3.01277871
120protein localization to mitochondrion (GO:0070585)3.00062307
121mRNA catabolic process (GO:0006402)2.99803535
122negative regulation of RNA splicing (GO:0033119)2.98703269
123DNA replication-dependent nucleosome assembly (GO:0006335)2.97880091
124DNA replication-dependent nucleosome organization (GO:0034723)2.97880091
1257-methylguanosine mRNA capping (GO:0006370)2.96615243
126cellular component biogenesis (GO:0044085)2.96370663
127histone exchange (GO:0043486)2.96094558
128RNA catabolic process (GO:0006401)2.95411047
129double-strand break repair via nonhomologous end joining (GO:0006303)2.95179486
130non-recombinational repair (GO:0000726)2.95179486
131tRNA aminoacylation (GO:0043039)2.94686411
132amino acid activation (GO:0043038)2.94686411
133tRNA aminoacylation for protein translation (GO:0006418)2.91880021
134DNA ligation (GO:0006266)2.91800895
135DNA synthesis involved in DNA repair (GO:0000731)2.89045946
136protein localization to chromosome, centromeric region (GO:0071459)2.88852598
1377-methylguanosine RNA capping (GO:0009452)2.88176040
138RNA capping (GO:0036260)2.88176040
139dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.88147306
140regulation of ubiquitin-protein transferase activity (GO:0051438)2.88024848
141regulation of mitotic spindle checkpoint (GO:1903504)2.86855073
142regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.86855073
143exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.86445042
144intra-S DNA damage checkpoint (GO:0031573)2.84785564
145regulation of double-strand break repair via homologous recombination (GO:0010569)2.84645266
146mitotic metaphase plate congression (GO:0007080)2.83604096
147nucleobase-containing small molecule interconversion (GO:0015949)2.83130832
148termination of RNA polymerase II transcription (GO:0006369)2.82586938
149protein-cofactor linkage (GO:0018065)2.82032601
150metallo-sulfur cluster assembly (GO:0031163)2.82019052
151iron-sulfur cluster assembly (GO:0016226)2.82019052
152histone H4-K12 acetylation (GO:0043983)2.81532817
153DNA replication-independent nucleosome assembly (GO:0006336)2.80085419
154DNA replication-independent nucleosome organization (GO:0034724)2.80085419
155pyrimidine nucleotide catabolic process (GO:0006244)2.78072468
156transcription-coupled nucleotide-excision repair (GO:0006283)2.77545928
157somatic recombination of immunoglobulin gene segments (GO:0016447)2.76721636
158RNA methylation (GO:0001510)2.74925840
159somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.74183475
160somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.74183475
161isotype switching (GO:0045190)2.74183475
162definitive hemopoiesis (GO:0060216)2.73410444
163negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.73051719
164nuclear pore complex assembly (GO:0051292)2.72024870
165base-excision repair (GO:0006284)2.72001849
166nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.71873143
167resolution of meiotic recombination intermediates (GO:0000712)2.70584670
168negative regulation of mRNA processing (GO:0050686)2.69915670
169viral mRNA export from host cell nucleus (GO:0046784)2.67557512

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.48216943
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.71597614
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.48549968
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.30117879
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.28540592
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.28100000
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.15874545
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.04992227
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.96076934
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.92054178
11MYC_19030024_ChIP-ChIP_MESCs_Mouse2.85855158
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.83805553
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.70453198
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.68486484
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.46245432
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.40693616
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.36350625
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.22078360
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.19607309
20* VDR_23849224_ChIP-Seq_CD4+_Human2.14396886
21XRN2_22483619_ChIP-Seq_HELA_Human2.08697595
22MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.99156197
23E2F1_18555785_ChIP-Seq_MESCs_Mouse1.95550396
24VDR_21846776_ChIP-Seq_THP-1_Human1.94113359
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.92580504
26TTF2_22483619_ChIP-Seq_HELA_Human1.90565228
27* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.89479289
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.88811229
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.87161048
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.87146417
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.86208356
32ZNF274_21170338_ChIP-Seq_K562_Hela1.85530204
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84830361
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.83033690
35FOXP3_21729870_ChIP-Seq_TREG_Human1.82526557
36ELK1_19687146_ChIP-ChIP_HELA_Human1.76835862
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76229308
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.75951850
39DCP1A_22483619_ChIP-Seq_HELA_Human1.74742636
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73952281
41SCL_19346495_ChIP-Seq_HPC-7_Human1.71080441
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.69283484
43RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68974747
44SALL1_21062744_ChIP-ChIP_HESCs_Human1.68691723
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.68539101
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64744252
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63056138
48MYC_22102868_ChIP-Seq_BL_Human1.62836563
49AR_21909140_ChIP-Seq_LNCAP_Human1.62382121
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60970565
51* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.60592820
52GABP_19822575_ChIP-Seq_HepG2_Human1.59616900
53STAT3_1855785_ChIP-Seq_MESCs_Mouse1.54309166
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53711720
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53691887
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.52519615
57SPI1_23547873_ChIP-Seq_NB4_Human1.49424219
58IGF1R_20145208_ChIP-Seq_DFB_Human1.44812876
59SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.41366682
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39943082
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39889754
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37163150
63PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.36810983
64* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36789103
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.35535963
66* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35020590
67ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34251750
68YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32035019
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.31510549
70HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.31445666
71SRF_21415370_ChIP-Seq_HL-1_Mouse1.30014075
72CIITA_25753668_ChIP-Seq_RAJI_Human1.30001714
73IRF8_22096565_ChIP-ChIP_GC-B_Human1.28006697
74E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.27084607
75ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26144812
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.24242157
77VDR_22108803_ChIP-Seq_LS180_Human1.22306066
78KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.21745265
79KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.21745265
80KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.21745265
81EWS_26573619_Chip-Seq_HEK293_Human1.20864875
82MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18428694
83KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.17909699
84NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.16648687
85SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15999109
86KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.15276198
87FUS_26573619_Chip-Seq_HEK293_Human1.15104548
88EGR1_19374776_ChIP-ChIP_THP-1_Human1.14704606
89SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14100148
90ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13209104
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12153606
92KDM5A_27292631_Chip-Seq_BREAST_Human1.09538946
93* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08012810
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.07135806
95MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05669668
96IRF8_21731497_ChIP-ChIP_J774_Mouse1.04487211
97IRF1_19129219_ChIP-ChIP_H3396_Human1.01869577
98ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01179639
99MYC_18940864_ChIP-ChIP_HL60_Human1.00240741
100NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.98655573
101ELK1_22589737_ChIP-Seq_MCF10A_Human0.98560344
102ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96807417
103NANOG_16153702_ChIP-ChIP_HESCs_Human0.95831542
104POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.95691201
105STAT1_20625510_ChIP-Seq_HELA_Human0.94518441
106* TFEB_21752829_ChIP-Seq_HELA_Human0.94089776
107PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93522026
108CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92905248
109VDR_24763502_ChIP-Seq_THP-1_Human0.92688595
110SOX17_20123909_ChIP-Seq_XEN_Mouse0.91845228
111E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91749251
112POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90957948
113CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90911372
114PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89847699
115RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87925969
116KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87629490
117DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.87447560
118RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.87350614
119HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.84843594
120CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.84677005
121SOX2_16153702_ChIP-ChIP_HESCs_Human0.79701667
122TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73389397
123RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.73314384
124CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.72994569
125TP53_22573176_ChIP-Seq_HFKS_Human0.72969323
126TAF15_26573619_Chip-Seq_HEK293_Human0.72517478
127GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.69994732
128TBX5_21415370_ChIP-Seq_HL-1_Mouse0.69244254
129FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.69042110
130AR_20517297_ChIP-Seq_VCAP_Human0.68241853
131POU5F1_16153702_ChIP-ChIP_HESCs_Human0.66989232
132SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.66360939
133HTT_18923047_ChIP-ChIP_STHdh_Human0.66345685

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.18120199
2MP0003693_abnormal_embryo_hatching5.02116341
3MP0009379_abnormal_foot_pigmentation3.65883290
4MP0010094_abnormal_chromosome_stability3.61418978
5MP0003111_abnormal_nucleus_morphology3.58930029
6MP0005174_abnormal_tail_pigmentation3.43623814
7MP0003077_abnormal_cell_cycle3.16447417
8MP0004957_abnormal_blastocyst_morpholog3.06021434
9MP0008058_abnormal_DNA_repair3.03874680
10MP0000372_irregular_coat_pigmentation2.96990287
11MP0000490_abnormal_crypts_of2.81502998
12MP0006292_abnormal_olfactory_placode2.68129660
13MP0002396_abnormal_hematopoietic_system2.62395544
14MP0000015_abnormal_ear_pigmentation2.36040974
15MP0008007_abnormal_cellular_replicative2.15263784
16MP0006035_abnormal_mitochondrial_morpho2.11294038
17MP0005075_abnormal_melanosome_morpholog2.08514338
18MP0005408_hypopigmentation2.01444544
19MP0002277_abnormal_respiratory_mucosa1.95602879
20MP0003567_abnormal_fetal_cardiomyocyte1.91733530
21MP0005397_hematopoietic_system_phenotyp1.87812223
22MP0001545_abnormal_hematopoietic_system1.87812223
23MP0002938_white_spotting1.79966024
24MP0001764_abnormal_homeostasis1.79225403
25MP0002095_abnormal_skin_pigmentation1.78556011
26MP0002102_abnormal_ear_morphology1.76673830
27MP0008932_abnormal_embryonic_tissue1.65579777
28MP0006072_abnormal_retinal_apoptosis1.64018942
29MP0001188_hyperpigmentation1.63840581
30MP0003123_paternal_imprinting1.63455525
31MP0003121_genomic_imprinting1.62143524
32MP0001348_abnormal_lacrimal_gland1.58107108
33MP0001984_abnormal_olfaction1.56972389
34MP0009697_abnormal_copulation1.54596252
35MP0009278_abnormal_bone_marrow1.54180519
36MP0008877_abnormal_DNA_methylation1.50891955
37MP0004147_increased_porphyrin_level1.48127560
38MP0003786_premature_aging1.46996517
39MP0003941_abnormal_skin_development1.46791611
40MP0000350_abnormal_cell_proliferation1.46540726
41MP0000313_abnormal_cell_death1.44852795
42MP0002090_abnormal_vision1.41088353
43MP0008789_abnormal_olfactory_epithelium1.40292906
44MP0005409_darkened_coat_color1.39708342
45MP0001529_abnormal_vocalization1.39220347
46MP0003806_abnormal_nucleotide_metabolis1.36376836
47MP0001293_anophthalmia1.35770407
48MP0004808_abnormal_hematopoietic_stem1.35422447
49MP0003186_abnormal_redox_activity1.33756311
50MP0003763_abnormal_thymus_physiology1.33521260
51MP0002138_abnormal_hepatobiliary_system1.33344230
52MP0003122_maternal_imprinting1.32627639
53MP0005253_abnormal_eye_physiology1.27585000
54MP0000465_gastrointestinal_hemorrhage1.27146091
55MP0000358_abnormal_cell_content/1.21872307
56MP0002398_abnormal_bone_marrow1.21453533
57MP0005084_abnormal_gallbladder_morpholo1.20040348
58MP0002019_abnormal_tumor_incidence1.19993298
59MP0005332_abnormal_amino_acid1.19721153
60MP0005379_endocrine/exocrine_gland_phen1.19414725
61MP0002163_abnormal_gland_morphology1.18570847
62MP0002210_abnormal_sex_determination1.18266922
63MP0003315_abnormal_perineum_morphology1.17262693
64MP0002254_reproductive_system_inflammat1.17109582
65MP0002736_abnormal_nociception_after1.16439177
66MP0005551_abnormal_eye_electrophysiolog1.13825857
67MP0001730_embryonic_growth_arrest1.11786372
68MP0003787_abnormal_imprinting1.11558685
69MP0005464_abnormal_platelet_physiology1.09850832
70MP0001835_abnormal_antigen_presentation1.08805956
71MP0003195_calcinosis1.08360865
72MP0002638_abnormal_pupillary_reflex1.07474961
73MP0000703_abnormal_thymus_morphology1.06540869
74MP0000689_abnormal_spleen_morphology1.05739200
75MP0009333_abnormal_splenocyte_physiolog1.04041910
76MP0006036_abnormal_mitochondrial_physio1.03413013
77MP0001986_abnormal_taste_sensitivity1.02902194
78MP0001119_abnormal_female_reproductive1.02187136
79MP0000678_abnormal_parathyroid_gland1.00733769
80MP0002160_abnormal_reproductive_system1.00394414
81MP0002722_abnormal_immune_system1.00175103
82MP0008995_early_reproductive_senescence0.99536870
83MP0000647_abnormal_sebaceous_gland0.99169113
84MP0002132_abnormal_respiratory_system0.98864284
85MP0005220_abnormal_exocrine_pancreas0.98187955
86MP0005025_abnormal_response_to0.97488949
87MP0003436_decreased_susceptibility_to0.96431256
88MP0001145_abnormal_male_reproductive0.96062319
89MP0002075_abnormal_coat/hair_pigmentati0.95909023
90MP0005380_embryogenesis_phenotype0.95621351
91MP0001672_abnormal_embryogenesis/_devel0.95621351
92MP0000470_abnormal_stomach_morphology0.94901321
93MP0003183_abnormal_peptide_metabolism0.94500142
94MP0002452_abnormal_antigen_presenting0.93002575
95MP0003718_maternal_effect0.92651417
96MP0010352_gastrointestinal_tract_polyps0.92202695
97MP0001324_abnormal_eye_pigmentation0.91809492
98MP0002429_abnormal_blood_cell0.91365232
99MP0002837_dystrophic_cardiac_calcinosis0.90926807
100MP0001666_abnormal_nutrient_absorption0.90923740
101MP0000716_abnormal_immune_system0.89136667
102MP0010155_abnormal_intestine_physiology0.89123530
103MP0001800_abnormal_humoral_immune0.88875242
104MP0003119_abnormal_digestive_system0.88584315
105MP0002148_abnormal_hypersensitivity_rea0.88446703
106MP0005394_taste/olfaction_phenotype0.88041914
107MP0005499_abnormal_olfactory_system0.88041914
108MP0005451_abnormal_body_composition0.87099898
109MP0000477_abnormal_intestine_morphology0.87072591
110MP0003937_abnormal_limbs/digits/tail_de0.86359400
111MP0005645_abnormal_hypothalamus_physiol0.85977990
112MP0001697_abnormal_embryo_size0.85927070
113MP0002233_abnormal_nose_morphology0.85253133
114MP0009046_muscle_twitch0.85108228
115MP0002723_abnormal_immune_serum0.83390523
116MP0003136_yellow_coat_color0.82904352
117MP0003828_pulmonary_edema0.81553095
118MP0010386_abnormal_urinary_bladder0.81124542
119MP0001186_pigmentation_phenotype0.80779856
120MP0003646_muscle_fatigue0.79855296
121MP0001727_abnormal_embryo_implantation0.79541108
122MP0003880_abnormal_central_pattern0.79372772
123MP0002080_prenatal_lethality0.79243979
124MP0002420_abnormal_adaptive_immunity0.79222723
125MP0002086_abnormal_extraembryonic_tissu0.78859948
126MP0003011_delayed_dark_adaptation0.78813892
127MP0000653_abnormal_sex_gland0.78695350
128MP0003984_embryonic_growth_retardation0.78011106
129MP0002085_abnormal_embryonic_tissue0.77857635
130MP0001819_abnormal_immune_cell0.77779854
131MP0005389_reproductive_system_phenotype0.77053677
132MP0009672_abnormal_birth_weight0.77028072
133MP0002249_abnormal_larynx_morphology0.76980775
134MP0002084_abnormal_developmental_patter0.76877406
135MP0005367_renal/urinary_system_phenotyp0.76778862
136MP0000516_abnormal_urinary_system0.76778862
137MP0008875_abnormal_xenobiotic_pharmacok0.76764960
138MP0001929_abnormal_gametogenesis0.76486110
139MP0002928_abnormal_bile_duct0.75316644
140MP0004133_heterotaxia0.75258516
141MP0001919_abnormal_reproductive_system0.75245899
142MP0003698_abnormal_male_reproductive0.75047892
143MP0002405_respiratory_system_inflammati0.74713290
144MP0002088_abnormal_embryonic_growth/wei0.74258013
145MP0003890_abnormal_embryonic-extraembry0.74037564
146MP0010234_abnormal_vibrissa_follicle0.73014179
147MP0002751_abnormal_autonomic_nervous0.71643537
148MP0000685_abnormal_immune_system0.71592757
149MP0006054_spinal_hemorrhage0.71269712
150MP0000681_abnormal_thyroid_gland0.69876972
151MP0000858_altered_metastatic_potential0.68627420
152MP0001485_abnormal_pinna_reflex0.67607557
153MP0005636_abnormal_mineral_homeostasis0.65804220
154MP0004215_abnormal_myocardial_fiber0.63790861
155MP0003137_abnormal_impulse_conducting0.62006084

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.33479345
2Reticulocytopenia (HP:0001896)5.18814260
3Acute necrotizing encephalopathy (HP:0006965)4.50106116
4Acute encephalopathy (HP:0006846)4.37518222
5Abnormal mitochondria in muscle tissue (HP:0008316)4.23785137
6Chromsome breakage (HP:0040012)4.14399412
7Breast hypoplasia (HP:0003187)4.13339553
8Mitochondrial inheritance (HP:0001427)3.95979475
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.92985573
10Increased CSF lactate (HP:0002490)3.92584794
11Pustule (HP:0200039)3.83712235
12Abnormality of cells of the erythroid lineage (HP:0012130)3.82146025
13Progressive macrocephaly (HP:0004481)3.72712505
14Hyperglycinemia (HP:0002154)3.72039336
15Aplastic anemia (HP:0001915)3.64917816
16Abnormal number of erythroid precursors (HP:0012131)3.60488308
17Hepatocellular necrosis (HP:0001404)3.58409700
18Reduced antithrombin III activity (HP:0001976)3.49616150
19Pallor (HP:0000980)3.48778693
20Thrombocytosis (HP:0001894)3.37136137
21Aplasia/Hypoplasia of the sacrum (HP:0008517)3.36056661
22Aplasia cutis congenita (HP:0001057)3.34613706
23Hepatic necrosis (HP:0002605)3.32648566
24Type I transferrin isoform profile (HP:0003642)3.29449429
25Cerebral edema (HP:0002181)3.28519684
26Macrocytic anemia (HP:0001972)3.26568798
27IgM deficiency (HP:0002850)3.20357886
28Abnormality of the preputium (HP:0100587)3.18940220
29Increased intramyocellular lipid droplets (HP:0012240)3.12819179
30Decreased activity of mitochondrial respiratory chain (HP:0008972)3.11770610
31Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.11770610
32Poikiloderma (HP:0001029)3.11673991
33Increased serum pyruvate (HP:0003542)3.09780430
34Cheilitis (HP:0100825)3.00377175
35Increased serum lactate (HP:0002151)2.95814657
36Agnosia (HP:0010524)2.95411968
37Petechiae (HP:0000967)2.95072200
38Lactic acidosis (HP:0003128)2.94834624
39Cerebral hypomyelination (HP:0006808)2.91603544
40Abnormality of glycolysis (HP:0004366)2.84469401
41Meckel diverticulum (HP:0002245)2.82928931
42Absent thumb (HP:0009777)2.80488735
43Abnormality of the ileum (HP:0001549)2.79987411
44Methylmalonic acidemia (HP:0002912)2.74187689
45Asplenia (HP:0001746)2.73786565
46Breech presentation (HP:0001623)2.73463657
47Abnormality of methionine metabolism (HP:0010901)2.71048154
48Hypochromic anemia (HP:0001931)2.69479825
49Exercise intolerance (HP:0003546)2.68314281
50Hyperglycinuria (HP:0003108)2.67681654
51Abnormality of serum amino acid levels (HP:0003112)2.64768501
52Microvesicular hepatic steatosis (HP:0001414)2.64211774
53Lethargy (HP:0001254)2.62411788
54Multiple enchondromatosis (HP:0005701)2.59424758
55Abnormality of glycine metabolism (HP:0010895)2.56056762
56Abnormality of serine family amino acid metabolism (HP:0010894)2.56056762
57Trismus (HP:0000211)2.55246109
58Exertional dyspnea (HP:0002875)2.53549600
59Premature graying of hair (HP:0002216)2.51484394
60Methylmalonic aciduria (HP:0012120)2.50886681
61Increased muscle lipid content (HP:0009058)2.50186654
62Prolonged bleeding time (HP:0003010)2.49648396
63Colon cancer (HP:0003003)2.49177931
64Gastrointestinal inflammation (HP:0004386)2.47914411
653-Methylglutaconic aciduria (HP:0003535)2.46287432
66Myelodysplasia (HP:0002863)2.45367814
67Aplasia/Hypoplasia of the spleen (HP:0010451)2.45233002
68Inflammation of the large intestine (HP:0002037)2.45228011
69Progressive inability to walk (HP:0002505)2.44306677
70Basal cell carcinoma (HP:0002671)2.42513143
71Leukodystrophy (HP:0002415)2.42198311
72Aplasia/Hypoplasia of the uvula (HP:0010293)2.40405533
73Prostate neoplasm (HP:0100787)2.40056451
74Respiratory failure (HP:0002878)2.38963895
75Oral leukoplakia (HP:0002745)2.38615733
76Abnormality of the renal collecting system (HP:0004742)2.38442423
77Abnormality of the labia minora (HP:0012880)2.37912457
78Absent radius (HP:0003974)2.33959540
79Increased hepatocellular lipid droplets (HP:0006565)2.32707220
80Duplicated collecting system (HP:0000081)2.32096760
81Triphalangeal thumb (HP:0001199)2.31521769
82Patellar aplasia (HP:0006443)2.31268609
83Abnormality of chromosome stability (HP:0003220)2.31112675
84Bone marrow hypocellularity (HP:0005528)2.27413716
85CNS demyelination (HP:0007305)2.27394905
86Clubbing of toes (HP:0100760)2.23228692
87Pancytopenia (HP:0001876)2.19903824
88Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.19224639
89Selective tooth agenesis (HP:0001592)2.17998994
90CNS hypomyelination (HP:0003429)2.16541218
91Respiratory difficulties (HP:0002880)2.15235234
92Abnormality of alanine metabolism (HP:0010916)2.12599361
93Hyperalaninemia (HP:0003348)2.12599361
94Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.12599361
95Pulmonary fibrosis (HP:0002206)2.12315583
96Abnormality of renal resorption (HP:0011038)2.11878255
97Absent forearm bone (HP:0003953)2.11057780
98Aplasia involving forearm bones (HP:0009822)2.11057780
99Abnormality of aspartate family amino acid metabolism (HP:0010899)2.10858495
100Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.10103049
101Optic disc pallor (HP:0000543)2.07331795
102Supernumerary spleens (HP:0009799)2.06429870
103Lipid accumulation in hepatocytes (HP:0006561)2.06381408
104Gingival bleeding (HP:0000225)2.04695916
105Aplasia/Hypoplasia of the patella (HP:0006498)2.04653081
106Hypoplasia of the radius (HP:0002984)2.03812708
107Septo-optic dysplasia (HP:0100842)2.03543833
108Premature loss of primary teeth (HP:0006323)2.02396577
109Horseshoe kidney (HP:0000085)2.01958530
110Abnormal protein glycosylation (HP:0012346)2.01272052
111Abnormal glycosylation (HP:0012345)2.01272052
112Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.01272052
113Abnormal protein N-linked glycosylation (HP:0012347)2.01272052
114Medial flaring of the eyebrow (HP:0010747)2.00561929
115Hyperinsulinemic hypoglycemia (HP:0000825)1.99565197
116Small intestinal stenosis (HP:0012848)1.98199541
117Duodenal stenosis (HP:0100867)1.98199541
118Pancreatic islet-cell hyperplasia (HP:0004510)1.97996998
119Lip pit (HP:0100267)1.97293198
120Abnormality of vitamin B metabolism (HP:0004340)1.96115099
121Tracheoesophageal fistula (HP:0002575)1.95071069
122Abnormal respiratory epithelium morphology (HP:0012253)1.93882919
123Abnormal respiratory motile cilium morphology (HP:0005938)1.93882919
124Abnormal spermatogenesis (HP:0008669)1.93739302
125Neoplasm of the adrenal gland (HP:0100631)1.92918894
126Abnormality of the vitamin B12 metabolism (HP:0004341)1.92617001
127Renal Fanconi syndrome (HP:0001994)1.92591240
128Slender long bone (HP:0003100)1.91040060
129Acute lymphatic leukemia (HP:0006721)1.90256645
130Abnormality of the anterior horn cell (HP:0006802)1.89883445
131Degeneration of anterior horn cells (HP:0002398)1.89883445
132Hypoglycemic coma (HP:0001325)1.89355189
133Spontaneous hematomas (HP:0007420)1.88153777
134Abnormality of dicarboxylic acid metabolism (HP:0010995)1.86780619
135Dicarboxylic aciduria (HP:0003215)1.86780619
13611 pairs of ribs (HP:0000878)1.85782425
137Tongue fasciculations (HP:0001308)1.85367440
138Hypoglycemic seizures (HP:0002173)1.84070392
139Dynein arm defect of respiratory motile cilia (HP:0012255)1.83645466
140Absent/shortened dynein arms (HP:0200106)1.83645466
141Glycosuria (HP:0003076)1.82516289
142Abnormality of urine glucose concentration (HP:0011016)1.82516289
143Renal cortical cysts (HP:0000803)1.82469837
144Nephrogenic diabetes insipidus (HP:0009806)1.81244919
145Carpal bone hypoplasia (HP:0001498)1.80834572
146Microretrognathia (HP:0000308)1.80312598
147Azoospermia (HP:0000027)1.78252217
148Abnormal lung lobation (HP:0002101)1.77798198
149Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.76927408
150Abnormality of the duodenum (HP:0002246)1.76806035
151Ependymoma (HP:0002888)1.76248005
152Microcytic anemia (HP:0001935)1.76073697
153Severe visual impairment (HP:0001141)1.75758892
154Rhabdomyosarcoma (HP:0002859)1.75660455
155Abnormal hemoglobin (HP:0011902)1.75558940
156Postnatal microcephaly (HP:0005484)1.75324343
157Microtia (HP:0008551)1.74796446
158Congenital primary aphakia (HP:0007707)1.73749313
159Cleft eyelid (HP:0000625)1.73713652
160Volvulus (HP:0002580)1.72886347
161Megaloblastic anemia (HP:0001889)1.72682406
162Aplasia/hypoplasia of the uterus (HP:0008684)1.71607899
163Absent rod-and cone-mediated responses on ERG (HP:0007688)1.70710131
164Obstructive lung disease (HP:0006536)1.70530640
165Chronic obstructive pulmonary disease (HP:0006510)1.70530640
166Rectal fistula (HP:0100590)1.70389322
167Rectovaginal fistula (HP:0000143)1.70389322
168X-linked dominant inheritance (HP:0001423)1.69639814
169Recurrent abscess formation (HP:0002722)1.69505694
170Abnormality of the nasal septum (HP:0000419)1.68690091

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.33262894
2NEK12.91019992
3CDC72.86727646
4BRD42.85365965
5MKNK22.85283314
6DYRK32.84694735
7VRK22.83902562
8PLK32.54871849
9WEE12.27788521
10CDK122.27560659
11BUB12.25627539
12NME22.18174563
13SRPK12.11842299
14MAP3K102.07590340
15BLK2.05810048
16TSSK62.03514675
17PASK2.02497873
18MKNK11.94141062
19YES11.93616543
20CDK71.90022129
21NEK21.80826840
22MAP4K21.79794708
23PLK11.78348815
24VRK11.78095757
25TTK1.76213397
26IRAK31.74344759
27WNK31.71345083
28PIM21.71092206
29ACVR1B1.60935304
30PDK21.59441405
31TAOK21.54191081
32TNK21.52781547
33TAOK31.49064073
34PLK41.48806579
35RPS6KB21.48609362
36BMPR1B1.46590585
37TLK11.46382852
38TESK21.45370272
39AURKB1.44459919
40PRPF4B1.37659411
41IRAK41.37550807
42CDK61.34112711
43NME11.33867060
44MAP3K111.28290314
45SCYL21.26444777
46TAF11.23684754
47CHEK21.20688306
48BCR1.20496743
49PAK41.15988627
50AURKA1.15403025
51CDK41.12085139
52ERBB31.09848252
53STK41.09541851
54CSF1R1.07279021
55BMX1.06916387
56ATR1.06298013
57MAPK151.04454227
58BTK1.03660674
59EEF2K1.03485345
60CCNB11.02911952
61CSNK1G31.02874608
62CSNK1G11.02209889
63RPS6KL11.01606540
64RPS6KC11.01606540
65DAPK10.99712760
66BRSK20.99267419
67LIMK10.95072990
68HIPK20.94056338
69MST40.92983680
70TEC0.92245617
71GRK60.91458236
72MATK0.90168491
73TNIK0.89679697
74CSNK1G20.89310156
75PNCK0.88468251
76MAPKAPK30.88175501
77GRK10.87447829
78MAP4K10.86826320
79CAMK10.86361377
80EIF2AK30.86351800
81KIT0.86345961
82PIM10.86047804
83BRSK10.84808007
84CHEK10.84802065
85RPS6KA60.84352858
86ZAK0.83966790
87PHKG10.83067871
88PHKG20.83067871
89FRK0.82760118
90LYN0.82246757
91DYRK1B0.80810382
92MAP3K60.78172632
93MAPK110.77893633
94STK160.77579192
95PLK20.72462960
96NEK90.72150573
97CSNK2A20.71357219
98CSNK1A1L0.70730710
99CDK30.70255839
100CSNK2A10.69259674
101ABL20.68975790
102CDK80.68455361
103TYK20.67831000
104AKT20.66110484
105EIF2AK20.63763643
106MAP2K70.63748933
107STK390.63739517
108MAP3K120.63532696
109CDK20.62743944
110ERBB40.61668149
111MAP2K60.61572078
112PBK0.61302722
113DYRK20.60994772
114DMPK0.60282936
115UHMK10.60049689
116ALK0.59414114
117TRPM70.58947903
118RPS6KA50.58506580
119ATM0.57792013
120PINK10.57627026
121CLK10.57562719
122PRKCG0.57257532
123TXK0.56009095
124EIF2AK10.53569074
125OXSR10.53550538
126FGR0.53465890
127TESK10.53057397
128NUAK10.52710925
129IKBKB0.52504146
130MAP3K40.48834963
131INSRR0.48000715
132BCKDK0.46676509
133CDK190.46634950
134FES0.45717221
135SIK30.45102577
136PRKCE0.44774382
137ADRBK20.44467379
138CSK0.43622297
139FLT30.43468579
140RPS6KA40.42886601
141MINK10.42356368
142PIK3CA0.41538632
143OBSCN0.39815327
144STK38L0.39492159
145PRKCI0.37054618
146CSNK1E0.34895966
147KDR0.31415492
148RIPK10.30993420
149CSNK1D0.27971978
150CDK10.26404995
151CSNK1A10.26146555
152NLK0.26125166

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.12333447
2DNA replication_Homo sapiens_hsa030305.06308075
3Mismatch repair_Homo sapiens_hsa034304.66913880
4Base excision repair_Homo sapiens_hsa034103.76846929
5Homologous recombination_Homo sapiens_hsa034403.40926162
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.40654237
7Spliceosome_Homo sapiens_hsa030403.24390847
8RNA polymerase_Homo sapiens_hsa030203.05492873
9Fanconi anemia pathway_Homo sapiens_hsa034602.86504658
10Nucleotide excision repair_Homo sapiens_hsa034202.66313869
11Pyrimidine metabolism_Homo sapiens_hsa002402.46641246
12One carbon pool by folate_Homo sapiens_hsa006702.41099160
13Proteasome_Homo sapiens_hsa030502.23214179
14Cell cycle_Homo sapiens_hsa041102.00606603
15Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.98301761
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95631476
17Propanoate metabolism_Homo sapiens_hsa006401.91462676
18RNA transport_Homo sapiens_hsa030131.84065831
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.74823168
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.73374039
21Fatty acid elongation_Homo sapiens_hsa000621.69461526
22Non-homologous end-joining_Homo sapiens_hsa034501.69220510
23RNA degradation_Homo sapiens_hsa030181.66755512
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.60288862
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.58770826
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55326439
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.53429164
28Basal transcription factors_Homo sapiens_hsa030221.50175869
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.48675247
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.37686660
31Purine metabolism_Homo sapiens_hsa002301.36799044
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.36072373
33Vitamin B6 metabolism_Homo sapiens_hsa007501.34348441
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.33565691
35Pyruvate metabolism_Homo sapiens_hsa006201.31908598
36mRNA surveillance pathway_Homo sapiens_hsa030151.27262131
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.22553990
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22547468
39Arachidonic acid metabolism_Homo sapiens_hsa005901.21812469
40Folate biosynthesis_Homo sapiens_hsa007901.21588637
41Butanoate metabolism_Homo sapiens_hsa006501.16130658
42Peroxisome_Homo sapiens_hsa041461.15439758
43Steroid biosynthesis_Homo sapiens_hsa001001.15322927
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.10941483
45Carbon metabolism_Homo sapiens_hsa012001.09166585
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.05190036
47Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04345028
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.04099085
49Systemic lupus erythematosus_Homo sapiens_hsa053221.02057716
50Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.01385873
51Linoleic acid metabolism_Homo sapiens_hsa005911.00321797
52Herpes simplex infection_Homo sapiens_hsa051680.97990586
53Thyroid cancer_Homo sapiens_hsa052160.93551506
54p53 signaling pathway_Homo sapiens_hsa041150.91937735
55Other glycan degradation_Homo sapiens_hsa005110.91574502
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91517136
57Fatty acid metabolism_Homo sapiens_hsa012120.90684866
58Selenocompound metabolism_Homo sapiens_hsa004500.87470926
59Arginine and proline metabolism_Homo sapiens_hsa003300.81116758
60Huntingtons disease_Homo sapiens_hsa050160.78631672
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77683711
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.76952973
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75412408
64Oocyte meiosis_Homo sapiens_hsa041140.74789586
65Fatty acid degradation_Homo sapiens_hsa000710.74400917
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73016834
67Cardiac muscle contraction_Homo sapiens_hsa042600.69744221
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69156825
69Epstein-Barr virus infection_Homo sapiens_hsa051690.69124756
70Shigellosis_Homo sapiens_hsa051310.68354675
71Viral carcinogenesis_Homo sapiens_hsa052030.67073399
72Tryptophan metabolism_Homo sapiens_hsa003800.66816738
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.65279867
74Oxidative phosphorylation_Homo sapiens_hsa001900.64534682
75Notch signaling pathway_Homo sapiens_hsa043300.62755889
76Primary immunodeficiency_Homo sapiens_hsa053400.59830660
77Hematopoietic cell lineage_Homo sapiens_hsa046400.58875164
78Protein export_Homo sapiens_hsa030600.57650886
79Caffeine metabolism_Homo sapiens_hsa002320.57383299
80Sulfur metabolism_Homo sapiens_hsa009200.57083211
81Vitamin digestion and absorption_Homo sapiens_hsa049770.56031423
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55035871
83Fructose and mannose metabolism_Homo sapiens_hsa000510.54268769
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.53429484
85Collecting duct acid secretion_Homo sapiens_hsa049660.53090373
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52926719
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48069914
88beta-Alanine metabolism_Homo sapiens_hsa004100.47605378
89Glutathione metabolism_Homo sapiens_hsa004800.46120547
90Phototransduction_Homo sapiens_hsa047440.44871569
91Fat digestion and absorption_Homo sapiens_hsa049750.44420335
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40060423
93Chemical carcinogenesis_Homo sapiens_hsa052040.40056298
94MicroRNAs in cancer_Homo sapiens_hsa052060.38832757
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38569297
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35373127
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.34491270
98Sulfur relay system_Homo sapiens_hsa041220.33872698
99Measles_Homo sapiens_hsa051620.33852398
100Parkinsons disease_Homo sapiens_hsa050120.33655470
101Metabolic pathways_Homo sapiens_hsa011000.33617983
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33157612
103Retinol metabolism_Homo sapiens_hsa008300.32669419
104Apoptosis_Homo sapiens_hsa042100.32195051
105B cell receptor signaling pathway_Homo sapiens_hsa046620.31745936
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31716414
107HTLV-I infection_Homo sapiens_hsa051660.30831902
108NF-kappa B signaling pathway_Homo sapiens_hsa040640.30538689
109Hepatitis B_Homo sapiens_hsa051610.28610828
110Alcoholism_Homo sapiens_hsa050340.28025627
111Acute myeloid leukemia_Homo sapiens_hsa052210.26864346
112Antigen processing and presentation_Homo sapiens_hsa046120.26448037
113Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26317298
114Tyrosine metabolism_Homo sapiens_hsa003500.24010368
115Pathways in cancer_Homo sapiens_hsa052000.23184313
116Steroid hormone biosynthesis_Homo sapiens_hsa001400.22893936
117Alzheimers disease_Homo sapiens_hsa050100.22603237
118Nitrogen metabolism_Homo sapiens_hsa009100.21800991
119Cysteine and methionine metabolism_Homo sapiens_hsa002700.21693827
120Galactose metabolism_Homo sapiens_hsa000520.21650365
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21538083
122N-Glycan biosynthesis_Homo sapiens_hsa005100.19640445
123Ether lipid metabolism_Homo sapiens_hsa005650.18618807
124Starch and sucrose metabolism_Homo sapiens_hsa005000.17976278
125Osteoclast differentiation_Homo sapiens_hsa043800.17707385
126Leishmaniasis_Homo sapiens_hsa051400.17386973
127Vibrio cholerae infection_Homo sapiens_hsa051100.16174071
128Small cell lung cancer_Homo sapiens_hsa052220.15796307
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.15791137
130Bladder cancer_Homo sapiens_hsa052190.15482183
131Arginine biosynthesis_Homo sapiens_hsa002200.14277554
132Wnt signaling pathway_Homo sapiens_hsa043100.13014024
133Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.12627389
134Melanoma_Homo sapiens_hsa052180.12491031
135Jak-STAT signaling pathway_Homo sapiens_hsa046300.12453418
136Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.11681512
137Legionellosis_Homo sapiens_hsa051340.11114323
138PI3K-Akt signaling pathway_Homo sapiens_hsa041510.09931480
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.08665201
140SNARE interactions in vesicular transport_Homo sapiens_hsa041300.08474901
141Regulation of autophagy_Homo sapiens_hsa041400.05926217
142Pentose phosphate pathway_Homo sapiens_hsa000300.05506124
143Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.05163906
144Lysine degradation_Homo sapiens_hsa003100.05140423
145Biosynthesis of amino acids_Homo sapiens_hsa012300.04443998
146Pentose and glucuronate interconversions_Homo sapiens_hsa000400.03622763

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