PEX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the AAA ATPase family, a large group of ATPases associated with diverse cellular activities. This protein is cytoplasmic but is often anchored to a peroxisomal membrane where it forms a heteromeric complex and plays a role in the import of proteins into peroxisomes and peroxisome biogenesis. Mutations in this gene have been associated with complementation group 1 peroxisomal disorders such as neonatal adrenoleukodystrophy, infantile Refsum disease, and Zellweger syndrome. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1indole-containing compound catabolic process (GO:0042436)5.86109972
2indolalkylamine catabolic process (GO:0046218)5.86109972
3tryptophan catabolic process (GO:0006569)5.86109972
4aromatic amino acid family catabolic process (GO:0009074)5.84133051
5L-phenylalanine catabolic process (GO:0006559)5.78106257
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.78106257
7tryptophan metabolic process (GO:0006568)5.73753282
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.11758810
9L-phenylalanine metabolic process (GO:0006558)5.11758810
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.92045167
11kynurenine metabolic process (GO:0070189)4.66365860
12cellular biogenic amine catabolic process (GO:0042402)4.65905910
13amine catabolic process (GO:0009310)4.65905910
14tyrosine metabolic process (GO:0006570)4.48264251
15urea cycle (GO:0000050)4.48111351
16urea metabolic process (GO:0019627)4.48111351
17bile acid biosynthetic process (GO:0006699)4.43223590
18indolalkylamine metabolic process (GO:0006586)4.40850849
19triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.35014937
20homocysteine metabolic process (GO:0050667)4.32669297
21rRNA catabolic process (GO:0016075)4.25593463
22aromatic amino acid family metabolic process (GO:0009072)4.23925761
23high-density lipoprotein particle remodeling (GO:0034375)4.19694671
24bile acid metabolic process (GO:0008206)4.06145072
25complement activation, alternative pathway (GO:0006957)4.02078666
26negative regulation of cytosolic calcium ion concentration (GO:0051481)3.95330191
27nitrogen cycle metabolic process (GO:0071941)3.94562298
28cysteine metabolic process (GO:0006534)3.92912983
29regulation of protein activation cascade (GO:2000257)3.91966891
30photoreceptor cell maintenance (GO:0045494)3.86051611
31regulation of bile acid biosynthetic process (GO:0070857)3.84031286
32NAD biosynthetic process (GO:0009435)3.81433574
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.80645338
34glyoxylate metabolic process (GO:0046487)3.78964215
35triglyceride homeostasis (GO:0070328)3.76779333
36acylglycerol homeostasis (GO:0055090)3.76779333
37monoubiquitinated protein deubiquitination (GO:0035520)3.74474805
38bile acid and bile salt transport (GO:0015721)3.68486281
39peptidyl-glutamic acid carboxylation (GO:0017187)3.68409030
40protein carboxylation (GO:0018214)3.68409030
41cholesterol efflux (GO:0033344)3.63332847
42regulation of complement activation (GO:0030449)3.59092672
43cilium or flagellum-dependent cell motility (GO:0001539)3.59029069
44serine family amino acid catabolic process (GO:0009071)3.58706211
45regulation of fibrinolysis (GO:0051917)3.56509913
46glycerophospholipid catabolic process (GO:0046475)3.56224147
47mitotic sister chromatid cohesion (GO:0007064)3.54448194
48alpha-amino acid catabolic process (GO:1901606)3.54259525
49negative regulation of lipase activity (GO:0060192)3.54233580
50regulation of triglyceride catabolic process (GO:0010896)3.53637932
51reverse cholesterol transport (GO:0043691)3.52311944
52plasma lipoprotein particle remodeling (GO:0034369)3.50994783
53protein-lipid complex remodeling (GO:0034368)3.50994783
54macromolecular complex remodeling (GO:0034367)3.50994783
55neural tube formation (GO:0001841)3.49967804
56cellular glucuronidation (GO:0052695)3.48400868
57coenzyme catabolic process (GO:0009109)3.46718457
58negative regulation of fibrinolysis (GO:0051918)3.45650288
59establishment of protein localization to Golgi (GO:0072600)3.44484581
60phospholipid efflux (GO:0033700)3.43222751
61regulation of cholesterol esterification (GO:0010872)3.42423135
62ncRNA catabolic process (GO:0034661)3.40618612
63very-low-density lipoprotein particle assembly (GO:0034379)3.36085248
64alpha-linolenic acid metabolic process (GO:0036109)3.34814255
65amino-acid betaine metabolic process (GO:0006577)3.34624432
66pyridine nucleotide biosynthetic process (GO:0019363)3.30007290
67nicotinamide nucleotide biosynthetic process (GO:0019359)3.30007290
68imidazole-containing compound metabolic process (GO:0052803)3.29744807
69drug catabolic process (GO:0042737)3.26619866
70phospholipid homeostasis (GO:0055091)3.23394918
71epithelial cilium movement (GO:0003351)3.19777604
72DNA strand renaturation (GO:0000733)3.17776458
73centriole replication (GO:0007099)3.17593538
74negative regulation of protein activation cascade (GO:2000258)3.15229041
75retinal cone cell development (GO:0046549)3.14129408
76fucose catabolic process (GO:0019317)3.13541372
77L-fucose metabolic process (GO:0042354)3.13541372
78L-fucose catabolic process (GO:0042355)3.13541372
79presynaptic membrane assembly (GO:0097105)3.13277064
80opsonization (GO:0008228)3.13064094
81negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.11508812
82negative regulation of translation, ncRNA-mediated (GO:0040033)3.11508812
83regulation of translation, ncRNA-mediated (GO:0045974)3.11508812
84sulfur amino acid catabolic process (GO:0000098)3.10397160
85blood coagulation, intrinsic pathway (GO:0007597)3.08766948
86cellular amino acid catabolic process (GO:0009063)3.08154636
87glucuronate metabolic process (GO:0019585)3.07626999
88uronic acid metabolic process (GO:0006063)3.07626999
89protein targeting to Golgi (GO:0000042)3.05883965
90benzene-containing compound metabolic process (GO:0042537)3.05144541
91histone H3-K9 methylation (GO:0051567)3.03885276
92linoleic acid metabolic process (GO:0043651)3.01580411
93indole-containing compound metabolic process (GO:0042430)3.00679018
94valine metabolic process (GO:0006573)2.99315471
95retrograde transport, vesicle recycling within Golgi (GO:0000301)2.94595630
96plasma lipoprotein particle assembly (GO:0034377)2.94266763
97low-density lipoprotein particle remodeling (GO:0034374)2.90886842
98cilium movement (GO:0003341)2.90760387
99response to pheromone (GO:0019236)2.84502855
100drug transmembrane transport (GO:0006855)2.83470807
101nucleotide transmembrane transport (GO:1901679)2.82716016
102kidney morphogenesis (GO:0060993)2.82672776
103arginine metabolic process (GO:0006525)2.81630151
104G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.81350502
105exogenous drug catabolic process (GO:0042738)2.81078636
106cellular ketone body metabolic process (GO:0046950)2.81017909
107protein activation cascade (GO:0072376)2.80580973
108fatty acid transmembrane transport (GO:1902001)2.80578063
109interkinetic nuclear migration (GO:0022027)2.79159751
110DNA damage induced protein phosphorylation (GO:0006975)2.78653335
111plasma lipoprotein particle organization (GO:0071827)2.78325581
112lysine catabolic process (GO:0006554)2.77822012
113lysine metabolic process (GO:0006553)2.77822012
114drug metabolic process (GO:0017144)2.77764395
115axoneme assembly (GO:0035082)2.77666840
116positive regulation of lipoprotein lipase activity (GO:0051006)2.76926014
117positive regulation of triglyceride lipase activity (GO:0061365)2.76926014
118adenosine metabolic process (GO:0046085)2.76657294
119cholesterol homeostasis (GO:0042632)2.76355197
120RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.72779673
121pyridine-containing compound biosynthetic process (GO:0072525)2.72164239
122plasma lipoprotein particle clearance (GO:0034381)2.71944839
123carnitine shuttle (GO:0006853)2.71233492
124protein localization to Golgi apparatus (GO:0034067)2.71023561
125nonmotile primary cilium assembly (GO:0035058)2.70726747
126androgen metabolic process (GO:0008209)2.70480248
127androgen biosynthetic process (GO:0006702)2.70365069
128cofactor catabolic process (GO:0051187)2.70117941
129presynaptic membrane organization (GO:0097090)2.68852255
130dicarboxylic acid biosynthetic process (GO:0043650)2.68697136
131synapsis (GO:0007129)2.68645722
132negative regulation of DNA-dependent DNA replication (GO:2000104)2.68507811
133sterol homeostasis (GO:0055092)2.67425211
134urate metabolic process (GO:0046415)2.67267891
135microtubule anchoring (GO:0034453)2.66394880
136organic acid catabolic process (GO:0016054)2.64925674
137carboxylic acid catabolic process (GO:0046395)2.64925674
138negative regulation of cholesterol transport (GO:0032375)2.64471650
139negative regulation of sterol transport (GO:0032372)2.64471650
140Golgi to endosome transport (GO:0006895)2.63359924
141replication fork processing (GO:0031297)2.62923837
142regulation of DNA endoreduplication (GO:0032875)2.60966327
143reciprocal meiotic recombination (GO:0007131)2.60737255
144reciprocal DNA recombination (GO:0035825)2.60737255
145protein K63-linked deubiquitination (GO:0070536)2.55480255
146histone mRNA catabolic process (GO:0071044)2.53773055
147sister chromatid cohesion (GO:0007062)2.53293395
148regulation of cilium movement (GO:0003352)2.52395022
149regulation of meiosis I (GO:0060631)2.50018943
150aspartate family amino acid catabolic process (GO:0009068)2.48090314
151cytoplasmic mRNA processing body assembly (GO:0033962)2.47812869
152neuron cell-cell adhesion (GO:0007158)2.45900432
153detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.45519424
154protein K11-linked deubiquitination (GO:0035871)2.44476184
155cilium organization (GO:0044782)2.44393857
156ketone body metabolic process (GO:1902224)2.43770478
157pyrimidine nucleobase catabolic process (GO:0006208)2.42676787
158peptidyl-lysine trimethylation (GO:0018023)2.40898732
159nucleobase catabolic process (GO:0046113)2.40835562
160positive regulation of histone H3-K4 methylation (GO:0051571)2.40801123
161regulation of sarcomere organization (GO:0060297)2.40513391
162C4-dicarboxylate transport (GO:0015740)2.39628856
163somatic hypermutation of immunoglobulin genes (GO:0016446)2.39584549
164somatic diversification of immune receptors via somatic mutation (GO:0002566)2.39584549
165histone H3-K9 modification (GO:0061647)2.39392113
166resolution of meiotic recombination intermediates (GO:0000712)2.38213315
167cellular response to sterol (GO:0036315)2.36370338
168histone H3-K4 trimethylation (GO:0080182)2.35983232
169carnitine transmembrane transport (GO:1902603)2.35646383
170cilium assembly (GO:0042384)2.34937452
171peptidyl-lysine methylation (GO:0018022)2.34664322
172amino-acid betaine transport (GO:0015838)2.33603534
173carnitine transport (GO:0015879)2.33603534
174polyol catabolic process (GO:0046174)2.33539332
175regulation of nuclear cell cycle DNA replication (GO:0033262)2.33178746
176microtubule organizing center organization (GO:0031023)2.31476957
177cerebellar Purkinje cell differentiation (GO:0021702)2.30516494
178neurotransmitter-gated ion channel clustering (GO:0072578)2.30367438
179DNA methylation involved in gamete generation (GO:0043046)2.30192829
180detection of light stimulus involved in sensory perception (GO:0050962)2.29941815
181detection of light stimulus involved in visual perception (GO:0050908)2.29941815
182DNA double-strand break processing (GO:0000729)2.29853764
183nucleus localization (GO:0051647)2.28859454
184positive regulation of cation channel activity (GO:2001259)2.28585223
185reflex (GO:0060004)2.28452633
186intraciliary transport (GO:0042073)2.27409179
187regulation of centriole replication (GO:0046599)2.24550947
188gene silencing by RNA (GO:0031047)2.23612622
189cilium morphogenesis (GO:0060271)2.23120552
190regulation of glucokinase activity (GO:0033131)2.23079270
191regulation of hexokinase activity (GO:1903299)2.23079270
192protein targeting to vacuole (GO:0006623)2.21991390
193establishment of protein localization to vacuole (GO:0072666)2.21991390

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_23403033_ChIP-Seq_LIVER_Mouse4.29695128
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.25825092
3GBX2_23144817_ChIP-Seq_PC3_Human3.42809616
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.33199544
5ZNF274_21170338_ChIP-Seq_K562_Hela2.82901820
6LXR_22158963_ChIP-Seq_LIVER_Mouse2.78885623
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.68666292
8TAF15_26573619_Chip-Seq_HEK293_Human2.41214446
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.37855614
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.32514873
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.30027254
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22294139
13* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.20645937
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.17456117
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.15938338
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.14443564
17SUZ12_27294783_Chip-Seq_NPCs_Mouse2.08426540
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.06416340
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.05497244
20FLI1_27457419_Chip-Seq_LIVER_Mouse2.05005224
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03597211
22NFE2_27457419_Chip-Seq_LIVER_Mouse1.96689881
23CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.96416019
24HTT_18923047_ChIP-ChIP_STHdh_Human1.87754225
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.86614455
26PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.86322600
27EZH2_27294783_Chip-Seq_NPCs_Mouse1.86188771
28IRF1_19129219_ChIP-ChIP_H3396_Human1.85564280
29AR_21572438_ChIP-Seq_LNCaP_Human1.82262724
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.81178362
31CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.76999920
32NANOG_18555785_Chip-Seq_ESCs_Mouse1.71040253
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70801320
34CBP_20019798_ChIP-Seq_JUKART_Human1.70493681
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.70493681
36P300_19829295_ChIP-Seq_ESCs_Human1.68688416
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.65233644
38EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.63718344
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63120281
40TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.62672965
41SUZ12_18555785_Chip-Seq_ESCs_Mouse1.60519990
42P53_22387025_ChIP-Seq_ESCs_Mouse1.60365454
43E2F1_18555785_Chip-Seq_ESCs_Mouse1.60306340
44BCAT_22108803_ChIP-Seq_LS180_Human1.58860344
45STAT3_18555785_Chip-Seq_ESCs_Mouse1.57883207
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57312289
47RUNX1_27457419_Chip-Seq_LIVER_Mouse1.53570723
48IGF1R_20145208_ChIP-Seq_DFB_Human1.51861526
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50511006
50EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.50178305
51NMYC_18555785_Chip-Seq_ESCs_Mouse1.48357479
52CMYC_18555785_Chip-Seq_ESCs_Mouse1.46960788
53CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.46176528
54* STAT3_23295773_ChIP-Seq_U87_Human1.45884000
55P300_18555785_Chip-Seq_ESCs_Mouse1.45793607
56OCT4_18555785_Chip-Seq_ESCs_Mouse1.44378622
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44260344
58EZH2_22144423_ChIP-Seq_EOC_Human1.42334448
59IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.42097336
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40796466
61SMAD4_21799915_ChIP-Seq_A2780_Human1.39408581
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.39162331
63SOX2_18555785_Chip-Seq_ESCs_Mouse1.39075094
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37954114
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.37715640
66CRX_20693478_ChIP-Seq_RETINA_Mouse1.37386127
67* ER_23166858_ChIP-Seq_MCF-7_Human1.36410564
68PU1_27457419_Chip-Seq_LIVER_Mouse1.35093545
69EWS_26573619_Chip-Seq_HEK293_Human1.34549546
70TCF4_22108803_ChIP-Seq_LS180_Human1.34147185
71OCT4_21477851_ChIP-Seq_ESCs_Mouse1.33958002
72CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32899057
73ESRRB_18555785_Chip-Seq_ESCs_Mouse1.32695528
74KLF4_18555785_Chip-Seq_ESCs_Mouse1.31934803
75KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.31397958
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29656142
77FUS_26573619_Chip-Seq_HEK293_Human1.29205895
78SMAD1_18555785_Chip-Seq_ESCs_Mouse1.29175011
79CTCF_18555785_Chip-Seq_ESCs_Mouse1.27568253
80TP53_16413492_ChIP-PET_HCT116_Human1.27254063
81ZFX_18555785_Chip-Seq_ESCs_Mouse1.26624287
82TAL1_26923725_Chip-Seq_HPCs_Mouse1.26422353
83SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.26011634
84FLI1_21867929_ChIP-Seq_TH2_Mouse1.24793937
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24298363
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24298363
87KAP1_22055183_ChIP-Seq_ESCs_Mouse1.24256038
88VDR_22108803_ChIP-Seq_LS180_Human1.24195562
89TCF4_23295773_ChIP-Seq_U87_Human1.22668884
90Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.21120520
91TP63_19390658_ChIP-ChIP_HaCaT_Human1.18977257
92* SOX2_19829295_ChIP-Seq_ESCs_Human1.17531423
93* NANOG_19829295_ChIP-Seq_ESCs_Human1.17531423
94SOX2_21211035_ChIP-Seq_LN229_Gbm1.15945375
95SMAD3_21741376_ChIP-Seq_EPCs_Human1.14653247
96CDX2_22108803_ChIP-Seq_LS180_Human1.13534546
97ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.13260977
98* PRDM14_20953172_ChIP-Seq_ESCs_Human1.12649132
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12599014
100ARNT_22903824_ChIP-Seq_MCF-7_Human1.12419196
101AHR_22903824_ChIP-Seq_MCF-7_Human1.11355879
102FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11063156
103RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10702302
104TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10104345
105CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09656882
106EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08110180
107HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.07755121
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.07226386
109SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06605934
110TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06515047
111ESR1_20079471_ChIP-ChIP_T-47D_Human1.06408467
112KDM2B_26808549_Chip-Seq_REH_Human1.05977000
113RUNX2_22187159_ChIP-Seq_PCA_Human1.05666147
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04759500
115FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.04409617
116BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04183803
117FOXA2_19822575_ChIP-Seq_HepG2_Human1.03569781
118AR_25329375_ChIP-Seq_VCAP_Human1.01879884
119RXR_22108803_ChIP-Seq_LS180_Human1.01582518
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01562524
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01343225
122OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01000386
123NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00275104
124TP53_18474530_ChIP-ChIP_U2OS_Human0.99450580
125VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99357599
126TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99289915
127RNF2_27304074_Chip-Seq_NSC_Mouse0.99288306
128GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98987163
129* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98759811
130SMAD4_21741376_ChIP-Seq_EPCs_Human0.97533391
131FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97477577
132CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97443218
133TP53_22573176_ChIP-Seq_HFKS_Human0.97313241
134IRF8_22096565_ChIP-ChIP_GC-B_Human0.97121349
135TBL1_22424771_ChIP-Seq_293T_Human0.96853221

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.82352517
2MP0005360_urolithiasis5.52067072
3MP0005365_abnormal_bile_salt5.22568706
4MP0005085_abnormal_gallbladder_physiolo4.99950154
5MP0008875_abnormal_xenobiotic_pharmacok4.00476770
6MP0003252_abnormal_bile_duct3.44547246
7MP0009697_abnormal_copulation3.18203054
8MP0002009_preneoplasia3.03470394
9MP0003195_calcinosis2.80776921
10MP0010329_abnormal_lipoprotein_level2.49029983
11MP0000569_abnormal_digit_pigmentation2.42401350
12MP0005451_abnormal_body_composition2.25756759
13MP0003890_abnormal_embryonic-extraembry2.14301677
14MP0005332_abnormal_amino_acid2.09576225
15MP0006292_abnormal_olfactory_placode2.09187409
16MP0005408_hypopigmentation2.08486912
17MP0004043_abnormal_pH_regulation2.06341011
18MP0005646_abnormal_pituitary_gland2.00314674
19MP0004019_abnormal_vitamin_homeostasis1.98620235
20MP0002876_abnormal_thyroid_physiology1.97951969
21MP0000566_synostosis1.97446843
22MP0001764_abnormal_homeostasis1.90138167
23MP0005647_abnormal_sex_gland1.86478690
24MP0005253_abnormal_eye_physiology1.83600281
25MP0001501_abnormal_sleep_pattern1.81479914
26MP0003868_abnormal_feces_composition1.80895746
27MP0002837_dystrophic_cardiac_calcinosis1.74536211
28MP0003283_abnormal_digestive_organ1.74333575
29MP0009046_muscle_twitch1.71445729
30MP0004885_abnormal_endolymph1.70979294
31MP0000383_abnormal_hair_follicle1.70355419
32MP0005171_absent_coat_pigmentation1.68646980
33MP0003806_abnormal_nucleotide_metabolis1.67682112
34MP0002396_abnormal_hematopoietic_system1.65393356
35MP0001984_abnormal_olfaction1.62892446
36MP0001968_abnormal_touch/_nociception1.61656021
37MP0002118_abnormal_lipid_homeostasis1.59064339
38MP0001666_abnormal_nutrient_absorption1.58111127
39MP0005386_behavior/neurological_phenoty1.54747575
40MP0004924_abnormal_behavior1.54747575
41MP0004084_abnormal_cardiac_muscle1.53403607
42MP0000631_abnormal_neuroendocrine_gland1.52927573
43MP0005187_abnormal_penis_morphology1.52656353
44MP0002736_abnormal_nociception_after1.52306503
45MP0004215_abnormal_myocardial_fiber1.50687378
46MP0009764_decreased_sensitivity_to1.48831059
47MP0009780_abnormal_chondrocyte_physiolo1.45273402
48MP0008058_abnormal_DNA_repair1.44114524
49MP0001529_abnormal_vocalization1.43600946
50MP0006072_abnormal_retinal_apoptosis1.41762353
51MP0005075_abnormal_melanosome_morpholog1.41247124
52MP0000609_abnormal_liver_physiology1.40009639
53MP0004145_abnormal_muscle_electrophysio1.39746920
54MP0005670_abnormal_white_adipose1.34190395
55MP0002234_abnormal_pharynx_morphology1.31303238
56MP0002272_abnormal_nervous_system1.25192332
57MP0004381_abnormal_hair_follicle1.23632462
58MP0002160_abnormal_reproductive_system1.23443051
59MP0002653_abnormal_ependyma_morphology1.21922085
60MP0001485_abnormal_pinna_reflex1.21634443
61MP0009840_abnormal_foam_cell1.21544825
62MP0009745_abnormal_behavioral_response1.20425748
63MP0003937_abnormal_limbs/digits/tail_de1.19539704
64MP0002138_abnormal_hepatobiliary_system1.19337824
65MP0002557_abnormal_social/conspecific_i1.19054496
66MP0010678_abnormal_skin_adnexa1.17217508
67MP0003787_abnormal_imprinting1.17043948
68MP0001986_abnormal_taste_sensitivity1.16750885
69MP0005083_abnormal_biliary_tract1.11997140
70MP0010094_abnormal_chromosome_stability1.11101452
71MP0002102_abnormal_ear_morphology1.10248551
72MP0008260_abnormal_autophagy1.08710932
73MP0009765_abnormal_xenobiotic_induced1.08496537
74MP0004742_abnormal_vestibular_system1.08239997
75MP0005645_abnormal_hypothalamus_physiol1.07984727
76MP0005334_abnormal_fat_pad1.07656829
77MP0002067_abnormal_sensory_capabilities1.06658790
78MP0003122_maternal_imprinting1.05218859
79MP0008995_early_reproductive_senescence1.04222620
80MP0001188_hyperpigmentation1.04087087
81MP0002229_neurodegeneration1.03310328
82MP0005266_abnormal_metabolism1.02418358
83MP0005319_abnormal_enzyme/_coenzyme1.01992949
84MP0001177_atelectasis1.01658885
85MP0003950_abnormal_plasma_membrane1.01080482
86MP0003121_genomic_imprinting0.99615911
87MP0003690_abnormal_glial_cell0.99463781
88MP0009763_increased_sensitivity_to0.98102665
89MP0002572_abnormal_emotion/affect_behav0.97755788
90MP0001929_abnormal_gametogenesis0.97432818
91MP0002735_abnormal_chemical_nociception0.97389730
92MP0003880_abnormal_central_pattern0.97344779
93MP0000778_abnormal_nervous_system0.96793170
94MP0008872_abnormal_physiological_respon0.96060234
95MP0008961_abnormal_basal_metabolism0.94807184
96MP0003119_abnormal_digestive_system0.94792401
97MP0004133_heterotaxia0.94645022
98MP0000579_abnormal_nail_morphology0.94411210
99MP0004085_abnormal_heartbeat0.94327282
100MP0003698_abnormal_male_reproductive0.94107774
101MP0003635_abnormal_synaptic_transmissio0.93234692
102MP0000647_abnormal_sebaceous_gland0.91935589
103MP0002064_seizures0.91701106
104MP0003011_delayed_dark_adaptation0.90019675
105MP0004130_abnormal_muscle_cell0.89581533
106MP0008775_abnormal_heart_ventricle0.89156302
107MP0005379_endocrine/exocrine_gland_phen0.88418041
108MP0002063_abnormal_learning/memory/cond0.88303833
109MP0004134_abnormal_chest_morphology0.88253522
110MP0000427_abnormal_hair_cycle0.88122550
111MP0003646_muscle_fatigue0.87385129
112MP0005551_abnormal_eye_electrophysiolog0.86804876
113MP0002638_abnormal_pupillary_reflex0.86517202
114MP0002909_abnormal_adrenal_gland0.86291967
115MP0009672_abnormal_birth_weight0.85839409
116MP0004036_abnormal_muscle_relaxation0.85475941
117MP0008789_abnormal_olfactory_epithelium0.84057669
118MP0003567_abnormal_fetal_cardiomyocyte0.82942126
119MP0005195_abnormal_posterior_eye0.82678838
120MP0002751_abnormal_autonomic_nervous0.81113835
121MP0005584_abnormal_enzyme/coenzyme_acti0.80340573
122MP0005391_vision/eye_phenotype0.79929955
123MP0003191_abnormal_cellular_cholesterol0.79908300
124MP0003943_abnormal_hepatobiliary_system0.79846234
125MP0000372_irregular_coat_pigmentation0.79563574
126MP0002822_catalepsy0.77917577
127MP0003718_maternal_effect0.77084603
128MP0008057_abnormal_DNA_replication0.76732030
129MP0002938_white_spotting0.76552479
130MP0004782_abnormal_surfactant_physiolog0.76527463
131MP0002882_abnormal_neuron_morphology0.75814759
132MP0004270_analgesia0.75501501
133MP0009703_decreased_birth_body0.75150525
134MP0002734_abnormal_mechanical_nocicepti0.74891042
135MP0010368_abnormal_lymphatic_system0.74715411
136MP0002752_abnormal_somatic_nervous0.74217790
137MP0005499_abnormal_olfactory_system0.73921260
138MP0005394_taste/olfaction_phenotype0.73921260
139MP0001661_extended_life_span0.73249638
140MP0001963_abnormal_hearing_physiology0.73201023
141MP0001119_abnormal_female_reproductive0.73095360
142MP0002132_abnormal_respiratory_system0.72499217
143MP0005389_reproductive_system_phenotype0.70398235
144MP0005220_abnormal_exocrine_pancreas0.70169952
145MP0001486_abnormal_startle_reflex0.69706848
146MP0000015_abnormal_ear_pigmentation0.69584275
147MP0009642_abnormal_blood_homeostasis0.69383534
148MP0000598_abnormal_liver_morphology0.69202277
149MP0001502_abnormal_circadian_rhythm0.67620701
150MP0003656_abnormal_erythrocyte_physiolo0.67329521
151MP0008877_abnormal_DNA_methylation0.66107155
152MP0000639_abnormal_adrenal_gland0.65775789
153MP0006276_abnormal_autonomic_nervous0.65532578
154MP0000371_diluted_coat_color0.63988589
155MP0008469_abnormal_protein_level0.63236626
156MP0010386_abnormal_urinary_bladder0.61684416
157MP0002971_abnormal_brown_adipose0.59545827
158MP0002249_abnormal_larynx_morphology0.59292436
159MP0009643_abnormal_urine_homeostasis0.58995692
160MP0003186_abnormal_redox_activity0.58471521
161MP0005248_abnormal_Harderian_gland0.57934849
162MP0002078_abnormal_glucose_homeostasis0.57852059
163MP0002928_abnormal_bile_duct0.57743728
164MP0001324_abnormal_eye_pigmentation0.57339687
165MP0004147_increased_porphyrin_level0.56149230
166MP0003953_abnormal_hormone_level0.55937075
167MP0005395_other_phenotype0.55615880
168MP0005409_darkened_coat_color0.55515994
169MP0002233_abnormal_nose_morphology0.54644629
170MP0001186_pigmentation_phenotype0.52450886

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.44779195
2Prolonged partial thromboplastin time (HP:0003645)4.94934573
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.55102431
4Joint hemorrhage (HP:0005261)4.38164687
5Epidermoid cyst (HP:0200040)4.02939114
6Deep venous thrombosis (HP:0002625)3.98194517
7Hyperlipoproteinemia (HP:0010980)3.86536779
8Abnormality of monocarboxylic acid metabolism (HP:0010996)3.76341033
9Hypochromic microcytic anemia (HP:0004840)3.59357175
10Conjugated hyperbilirubinemia (HP:0002908)3.58514406
11Abnormality of methionine metabolism (HP:0010901)3.58483415
12Hypobetalipoproteinemia (HP:0003563)3.49513583
13Chronic hepatic failure (HP:0100626)3.46099931
14Xanthomatosis (HP:0000991)3.24950357
15Pancreatic cysts (HP:0001737)3.22410098
16Complement deficiency (HP:0004431)3.20412004
17Fair hair (HP:0002286)3.18342512
18Abnormality of aspartate family amino acid metabolism (HP:0010899)3.16668775
19Abnormality of the renal medulla (HP:0100957)3.12151772
20Nephronophthisis (HP:0000090)3.11282864
21Colon cancer (HP:0003003)3.06938118
22Stomach cancer (HP:0012126)3.05454704
23Abnormality of midbrain morphology (HP:0002418)3.05012658
24Molar tooth sign on MRI (HP:0002419)3.05012658
25Neoplasm of the adrenal cortex (HP:0100641)3.03611745
26Abnormality of sulfur amino acid metabolism (HP:0004339)3.02825687
27Abnormality of pyrimidine metabolism (HP:0004353)3.02560281
28Pancreatic fibrosis (HP:0100732)3.00485322
29Fat malabsorption (HP:0002630)2.99415586
30Volvulus (HP:0002580)2.97776975
31Abnormality of glutamine family amino acid metabolism (HP:0010902)2.93661463
32* Renal cortical cysts (HP:0000803)2.92223107
33Type II lissencephaly (HP:0007260)2.89091756
34Cerebellar dysplasia (HP:0007033)2.88555384
35Gaze-evoked nystagmus (HP:0000640)2.88120126
36Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.86139413
37Prostate neoplasm (HP:0100787)2.82866145
38Osteomalacia (HP:0002749)2.82795567
39Hypoglycemic seizures (HP:0002173)2.78821642
40Proximal tubulopathy (HP:0000114)2.72829389
41Hypolipoproteinemia (HP:0010981)2.72305420
42Hypoglycemic coma (HP:0001325)2.69798945
43Chromosomal breakage induced by crosslinking agents (HP:0003221)2.69455591
44Abnormality of the common coagulation pathway (HP:0010990)2.67758385
45Hyperventilation (HP:0002883)2.64649279
46Generalized hypopigmentation of hair (HP:0011358)2.61085624
47Enlarged kidneys (HP:0000105)2.58897579
48Hypoalphalipoproteinemia (HP:0003233)2.58128073
49Hypercholesterolemia (HP:0003124)2.55074137
50Chromsome breakage (HP:0040012)2.52275223
51Tubulointerstitial nephritis (HP:0001970)2.51460786
52Hepatoblastoma (HP:0002884)2.50753646
53Abnormality of the intrinsic pathway (HP:0010989)2.50618161
54Hyperglycinemia (HP:0002154)2.41540895
55Hyperglycinuria (HP:0003108)2.40713170
56Dynein arm defect of respiratory motile cilia (HP:0012255)2.38204036
57Absent/shortened dynein arms (HP:0200106)2.38204036
58Symptomatic seizures (HP:0011145)2.35834501
59Steatorrhea (HP:0002570)2.35070403
60Gingival bleeding (HP:0000225)2.27522981
61Spontaneous abortion (HP:0005268)2.26465885
62Drooling (HP:0002307)2.25142732
63Glioma (HP:0009733)2.23609411
64Alveolar cell carcinoma (HP:0006519)2.23164325
65True hermaphroditism (HP:0010459)2.22724531
66Abnormality of the prostate (HP:0008775)2.19591747
67Pigmentary retinal degeneration (HP:0001146)2.18895668
68Vascular calcification (HP:0004934)2.18407533
69Progressive inability to walk (HP:0002505)2.16499531
70Abnormal hair whorl (HP:0010721)2.13492273
71Neoplasm of the tracheobronchial system (HP:0100552)2.13383898
72Congenital stationary night blindness (HP:0007642)2.12700859
73Neoplasm of the oral cavity (HP:0100649)2.11715892
74Hyperkalemia (HP:0002153)2.11305631
75Tubular atrophy (HP:0000092)2.10314621
76Abnormal respiratory motile cilium morphology (HP:0005938)2.10038334
77Abnormal respiratory epithelium morphology (HP:0012253)2.10038334
78Hypophosphatemic rickets (HP:0004912)2.09142506
79Widely spaced teeth (HP:0000687)2.09016292
80Blue irides (HP:0000635)2.08951468
81Inability to walk (HP:0002540)2.08444617
82Hypoplastic ischia (HP:0003175)2.07231436
83Broad-based gait (HP:0002136)2.06130206
84Abnormality of serum amino acid levels (HP:0003112)2.06029819
85Abnormality of serine family amino acid metabolism (HP:0010894)2.05014937
86Abnormality of glycine metabolism (HP:0010895)2.05014937
87Bile duct proliferation (HP:0001408)2.04199120
88Abnormal biliary tract physiology (HP:0012439)2.04199120
89Abnormal drinking behavior (HP:0030082)2.03121865
90Polydipsia (HP:0001959)2.03121865
91Abnormality of nucleobase metabolism (HP:0010932)2.02552142
92Cystic liver disease (HP:0006706)2.02317875
93Astrocytoma (HP:0009592)2.00694290
94Abnormality of the astrocytes (HP:0100707)2.00694290
95Thyroid-stimulating hormone excess (HP:0002925)2.00527498
96Abnormality of the ischium (HP:0003174)2.00265304
97Excessive salivation (HP:0003781)1.99544246
98Aplasia/Hypoplasia of the tibia (HP:0005772)1.99044039
99Abnormality of complement system (HP:0005339)1.97659420
100* Abnormality of the renal cortex (HP:0011035)1.97462425
101Febrile seizures (HP:0002373)1.97435397
102Genetic anticipation (HP:0003743)1.97247956
103Hyperammonemia (HP:0001987)1.97195610
104Intestinal atresia (HP:0011100)1.95921984
105Myocardial infarction (HP:0001658)1.95126209
106Abnormality of the labia minora (HP:0012880)1.95056879
107Poor coordination (HP:0002370)1.95019696
108Lissencephaly (HP:0001339)1.94133551
109Attenuation of retinal blood vessels (HP:0007843)1.93878909
110Ketosis (HP:0001946)1.93534719
111Neonatal hypoglycemia (HP:0001998)1.93407669
112Decreased circulating renin level (HP:0003351)1.93100306
113Thyroid carcinoma (HP:0002890)1.91044122
114Abnormal ciliary motility (HP:0012262)1.90270504
115Abnormality of incisor morphology (HP:0011063)1.89819785
116Genital tract atresia (HP:0001827)1.89755852
117Tubulointerstitial abnormality (HP:0001969)1.88993840
118Patchy hypopigmentation of hair (HP:0011365)1.88214136
119Generalized aminoaciduria (HP:0002909)1.88039977
120Medulloblastoma (HP:0002885)1.86130797
121Microvesicular hepatic steatosis (HP:0001414)1.85993959
122Absent speech (HP:0001344)1.85917804
123Hypoplastic iliac wings (HP:0002866)1.85689701
124Opisthotonus (HP:0002179)1.85436592
125Congenital hepatic fibrosis (HP:0002612)1.84925259
126Hydroxyprolinuria (HP:0003080)1.84912359
127Abnormality of proline metabolism (HP:0010907)1.84912359
128Hyperbilirubinemia (HP:0002904)1.84298952
129Recurrent gram-negative bacterial infections (HP:0005420)1.83538961
130Oligodactyly (hands) (HP:0001180)1.83098092
131Truncal obesity (HP:0001956)1.82326511
132Mitral stenosis (HP:0001718)1.81896085
133Abnormality of chromosome stability (HP:0003220)1.81091788
134White forelock (HP:0002211)1.80955575
135Papillary thyroid carcinoma (HP:0002895)1.80783449
136Birth length less than 3rd percentile (HP:0003561)1.79782865
137Polyuria (HP:0000103)1.78000327
138Vaginal atresia (HP:0000148)1.77703164
139Hypoplasia of the fovea (HP:0007750)1.77348244
140Aplasia/Hypoplasia of the fovea (HP:0008060)1.77348244
141Cardiovascular calcification (HP:0011915)1.77295378
142Hyperglycemia (HP:0003074)1.75541888
143Abnormality of potassium homeostasis (HP:0011042)1.75251859
144* Abnormality of fatty-acid metabolism (HP:0004359)1.75086730
145* Abnormal biliary tract morphology (HP:0012440)1.74679667
146Nephrogenic diabetes insipidus (HP:0009806)1.74459999
147Postaxial foot polydactyly (HP:0001830)1.74379771
148Abnormality of the fingertips (HP:0001211)1.73430035
149Medial flaring of the eyebrow (HP:0010747)1.73199770
150Arthropathy (HP:0003040)1.72958293
151Epileptic encephalopathy (HP:0200134)1.72478647
152Partial agenesis of the corpus callosum (HP:0001338)1.72271847
153Confusion (HP:0001289)1.71962902
154Aplasia/Hypoplasia of the uvula (HP:0010293)1.71261290
155Hypoplastic labia majora (HP:0000059)1.70287229
156Congenital primary aphakia (HP:0007707)1.70174400
157Optic neuritis (HP:0100653)1.69731126
158Retrobulbar optic neuritis (HP:0100654)1.69731126
159Delayed CNS myelination (HP:0002188)1.69628546
160Rickets (HP:0002748)1.69569458
161Hepatocellular carcinoma (HP:0001402)1.69283380
162Systemic lupus erythematosus (HP:0002725)1.68534859
163Gastrointestinal atresia (HP:0002589)1.68450356
164Progressive cerebellar ataxia (HP:0002073)1.68083727
165* Prolonged neonatal jaundice (HP:0006579)1.66677310
166Clumsiness (HP:0002312)1.66654542
167Abnormality of homocysteine metabolism (HP:0010919)1.65855507
168Homocystinuria (HP:0002156)1.65855507
169Abnormality of the pons (HP:0007361)1.65247298
170Abolished electroretinogram (ERG) (HP:0000550)1.64969880
171Calf muscle hypertrophy (HP:0008981)1.64673174
172Pancreatic islet-cell hyperplasia (HP:0004510)1.63447426
173Hypoplasia of the pons (HP:0012110)1.63286004
174Gait imbalance (HP:0002141)1.62927781
175Abnormal pancreas size (HP:0012094)1.62431877
176Abnormality of chloride homeostasis (HP:0011422)1.62303299
177* Protruding tongue (HP:0010808)1.62211583
178Hyperaldosteronism (HP:0000859)1.61168352
179Sloping forehead (HP:0000340)1.60620893

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR3.05797082
2CASK2.99006840
3MAP3K142.62277653
4EIF2AK22.51051711
5CAMK1G2.46622676
6NUAK12.45198743
7WNK32.40239468
8MAP2K72.36447370
9MAP4K22.28816300
10BRD42.18155801
11TAOK32.14331510
12SGK22.14005890
13ZAK2.11650390
14STK38L2.09257122
15MAP2K42.07353022
16CAMK1D1.99472452
17MAP3K131.82382591
18MAP3K41.78664890
19LATS11.75187088
20MAP3K71.74993454
21OBSCN1.70882766
22AKT31.64100824
23SGK4941.61777989
24SGK2231.61777989
25CAMKK21.60108214
26BMPR1B1.55677753
27BMPR21.52833214
28CDK31.51483103
29ERBB41.48413877
30IRAK41.46271697
31IRAK31.42122311
32SGK31.40124728
33PINK11.35206494
34PRPF4B1.34081147
35FRK1.33717886
36WNK41.31796648
37ERBB31.30087552
38NEK61.29849561
39PIK3CA1.25836790
40SIK11.23568067
41CSNK1G21.17206651
42CSNK1G11.16593499
43EIF2AK11.16023816
44TNK21.15890352
45BRSK21.12328329
46YES11.11877285
47MKNK21.10705403
48EPHA31.09515788
49PNCK1.08213967
50EIF2AK31.07309661
51NTRK31.06459163
52NEK21.06427070
53MARK11.05532559
54EPHA41.05059805
55TXK1.04112476
56CSNK1G31.03461796
57NTRK21.02587812
58MKNK11.02579356
59TNIK0.99207379
60SCYL20.98650872
61SIK30.96578631
62CDK80.94524382
63MAP2K60.92433307
64FGFR20.91788100
65PLK40.89859544
66STK390.88874944
67MAP2K30.88784967
68KIT0.88350401
69PHKG20.84469209
70PHKG10.84469209
71ATM0.83561893
72PKN10.83213751
73BCR0.82544328
74STK30.82264171
75MAPK70.81677636
76TGFBR10.81160906
77MET0.80787538
78MAPK130.80463271
79CHUK0.79650288
80EEF2K0.79582706
81FGFR40.78731441
82MST1R0.77314823
83IKBKE0.77028727
84PRKAA20.75921629
85TEC0.75379259
86PASK0.72400290
87PAK30.69483386
88RPS6KB20.69296494
89BCKDK0.69068353
90WNK10.68411278
91IRAK20.66842849
92TIE10.64199767
93DYRK1A0.63518490
94SRPK10.62431731
95CSNK1D0.60876784
96MAPKAPK50.59878154
97GRK10.59627013
98CAMKK10.59449869
99IKBKB0.59152291
100STK110.59088791
101MAPK120.58213562
102VRK10.57905934
103ADRBK20.56977198
104CAMK40.56424586
105RPS6KB10.56193679
106CDK120.56001348
107SGK10.55966077
108DAPK20.55246059
109PIK3CG0.54883639
110PRKCQ0.54664833
111FGFR30.50996886
112IRAK10.50827323
113JAK10.50260287
114PRKCE0.50203816
115ATR0.49963408
116ACVR1B0.49494752
117PRKDC0.49291220
118STK380.48468036
119MAPK110.48466758
120NLK0.48104210
121JAK30.47570457
122MUSK0.47090823
123PRKAA10.46345769
124CSNK1E0.46205339
125OXSR10.44632890
126CAMK2A0.43895332
127PLK20.43836047
128DYRK20.43598614
129CSNK1A1L0.43550102
130RPS6KA40.42552801
131CSF1R0.42526174
132MAPK100.41904705
133MAP3K60.41580661
134CCNB10.41542352
135TRPM70.41209749
136CHEK20.40358455
137CLK10.36912254
138CDK90.36728404
139FLT30.36441640
140PRKCZ0.35455889
141PLK30.34230212
142CAMK10.33103597

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.09260689
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.97958843
3Complement and coagulation cascades_Homo sapiens_hsa046102.79771371
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.71895540
5Tryptophan metabolism_Homo sapiens_hsa003802.65514718
6Steroid hormone biosynthesis_Homo sapiens_hsa001402.47622307
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.31697208
8Arginine biosynthesis_Homo sapiens_hsa002202.26292265
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.24373643
10* Peroxisome_Homo sapiens_hsa041462.22065543
11Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.21396724
12Histidine metabolism_Homo sapiens_hsa003402.21026875
13beta-Alanine metabolism_Homo sapiens_hsa004102.19574751
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.16068439
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.14438142
16Fatty acid degradation_Homo sapiens_hsa000712.07465633
17Nitrogen metabolism_Homo sapiens_hsa009102.04539064
18Retinol metabolism_Homo sapiens_hsa008302.01976097
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.00920262
20Caffeine metabolism_Homo sapiens_hsa002322.00918920
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.92117827
22Chemical carcinogenesis_Homo sapiens_hsa052041.90728885
23Butanoate metabolism_Homo sapiens_hsa006501.86946233
24Steroid biosynthesis_Homo sapiens_hsa001001.85355072
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.80294696
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.74731238
27ABC transporters_Homo sapiens_hsa020101.74220624
28Staphylococcus aureus infection_Homo sapiens_hsa051501.73548624
29Fatty acid elongation_Homo sapiens_hsa000621.67136620
30Propanoate metabolism_Homo sapiens_hsa006401.62693509
31Vitamin digestion and absorption_Homo sapiens_hsa049771.61130725
32Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.58978069
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.54698400
34Fatty acid metabolism_Homo sapiens_hsa012121.53245294
35PPAR signaling pathway_Homo sapiens_hsa033201.50682460
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.47146285
37Tyrosine metabolism_Homo sapiens_hsa003501.44735310
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.41570309
39Olfactory transduction_Homo sapiens_hsa047401.38452624
40Vitamin B6 metabolism_Homo sapiens_hsa007501.35527202
41Lysine degradation_Homo sapiens_hsa003101.35483647
42Starch and sucrose metabolism_Homo sapiens_hsa005001.32888612
43RNA degradation_Homo sapiens_hsa030181.32851777
44Phenylalanine metabolism_Homo sapiens_hsa003601.29921961
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23712814
46Sulfur metabolism_Homo sapiens_hsa009201.23609579
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15997930
48Glutamatergic synapse_Homo sapiens_hsa047241.09166484
49Bile secretion_Homo sapiens_hsa049761.07884609
50Circadian entrainment_Homo sapiens_hsa047131.07800198
51Insulin secretion_Homo sapiens_hsa049111.05869401
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03063302
53Selenocompound metabolism_Homo sapiens_hsa004500.98931434
54One carbon pool by folate_Homo sapiens_hsa006700.95353229
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.94985067
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.94309598
57Dorso-ventral axis formation_Homo sapiens_hsa043200.92943029
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91676052
59GABAergic synapse_Homo sapiens_hsa047270.88628850
60Calcium signaling pathway_Homo sapiens_hsa040200.87753998
61Renin secretion_Homo sapiens_hsa049240.87261202
62Arginine and proline metabolism_Homo sapiens_hsa003300.87236535
63Long-term depression_Homo sapiens_hsa047300.85078809
64Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.83355748
65Linoleic acid metabolism_Homo sapiens_hsa005910.82688609
66mRNA surveillance pathway_Homo sapiens_hsa030150.81547460
67Folate biosynthesis_Homo sapiens_hsa007900.78122479
68Inositol phosphate metabolism_Homo sapiens_hsa005620.77041823
69Serotonergic synapse_Homo sapiens_hsa047260.75868297
70Morphine addiction_Homo sapiens_hsa050320.75550341
71Ovarian steroidogenesis_Homo sapiens_hsa049130.75099584
72Amphetamine addiction_Homo sapiens_hsa050310.74960263
73Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74206630
74Salivary secretion_Homo sapiens_hsa049700.70742607
75Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70523131
76Dopaminergic synapse_Homo sapiens_hsa047280.70239329
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.69393685
78Vascular smooth muscle contraction_Homo sapiens_hsa042700.67560241
79Pancreatic secretion_Homo sapiens_hsa049720.66527137
80Thyroid hormone synthesis_Homo sapiens_hsa049180.64709927
81Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.63706649
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62499606
83Oocyte meiosis_Homo sapiens_hsa041140.61348966
84Oxytocin signaling pathway_Homo sapiens_hsa049210.59607918
85Arachidonic acid metabolism_Homo sapiens_hsa005900.59530742
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58678540
87Glucagon signaling pathway_Homo sapiens_hsa049220.58114928
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57755513
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57579060
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57199210
91Pyruvate metabolism_Homo sapiens_hsa006200.56482817
92cAMP signaling pathway_Homo sapiens_hsa040240.52894877
93Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52263214
94Glycerolipid metabolism_Homo sapiens_hsa005610.52171149
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49885129
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.49627390
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49370168
98Gastric acid secretion_Homo sapiens_hsa049710.48812386
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48386946
100Protein export_Homo sapiens_hsa030600.48358392
101Fat digestion and absorption_Homo sapiens_hsa049750.48219127
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46264160
103Glutathione metabolism_Homo sapiens_hsa004800.46163737
104Purine metabolism_Homo sapiens_hsa002300.45962347
105Fatty acid biosynthesis_Homo sapiens_hsa000610.44998159
106RNA transport_Homo sapiens_hsa030130.44168822
107Ether lipid metabolism_Homo sapiens_hsa005650.43672676
108Fanconi anemia pathway_Homo sapiens_hsa034600.43591611
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43384541
110Metabolic pathways_Homo sapiens_hsa011000.43121427
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42420985
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33067498
113Toll-like receptor signaling pathway_Homo sapiens_hsa046200.31445878
114Graft-versus-host disease_Homo sapiens_hsa053320.31438456
115Nicotine addiction_Homo sapiens_hsa050330.29316995
116Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28623896
117Circadian rhythm_Homo sapiens_hsa047100.25691376
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.21905500
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.21576351
1202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.21022406
121Hepatitis C_Homo sapiens_hsa051600.19754789
122Prion diseases_Homo sapiens_hsa050200.19511167
123Herpes simplex infection_Homo sapiens_hsa051680.17802097
124Basal transcription factors_Homo sapiens_hsa030220.17796028
125Taste transduction_Homo sapiens_hsa047420.17777102
126Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17515534
127Homologous recombination_Homo sapiens_hsa034400.16394028
128Cyanoamino acid metabolism_Homo sapiens_hsa004600.15472047
129Non-homologous end-joining_Homo sapiens_hsa034500.14829369
130Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.14570993
131Regulation of autophagy_Homo sapiens_hsa041400.13859303
132Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.13701914
133Phototransduction_Homo sapiens_hsa047440.13369209
134Autoimmune thyroid disease_Homo sapiens_hsa053200.12687630
135Influenza A_Homo sapiens_hsa051640.11932245
136Intestinal immune network for IgA production_Homo sapiens_hsa046720.11574292
137Type II diabetes mellitus_Homo sapiens_hsa049300.10709267
138Allograft rejection_Homo sapiens_hsa053300.10427174
139Biosynthesis of amino acids_Homo sapiens_hsa012300.06109114
140African trypanosomiasis_Homo sapiens_hsa051430.04390840
141Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.04116539

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