PEX10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein involved in import of peroxisomal matrix proteins. This protein localizes to the peroxisomal membrane. Mutations in this gene result in phenotypes within the Zellweger spectrum of peroxisomal biogenesis disorders, ranging from neonatal adrenoleukodystrophy to Zellweger syndrome. Alternative splicing results in two transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)6.54225750
2DNA deamination (GO:0045006)5.60125362
3protein retention in ER lumen (GO:0006621)5.10820770
4protein maturation by protein folding (GO:0022417)4.63172266
5maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.60265819
6proline metabolic process (GO:0006560)4.56128185
7regulation of mitochondrial translation (GO:0070129)4.37175010
8oxidative phosphorylation (GO:0006119)4.30200408
9folic acid-containing compound biosynthetic process (GO:0009396)4.20599260
10mitochondrial calcium ion transport (GO:0006851)4.08280923
11IMP biosynthetic process (GO:0006188)4.02561619
12peptidyl-arginine methylation (GO:0018216)3.96085276
13peptidyl-arginine N-methylation (GO:0035246)3.96085276
14tricarboxylic acid cycle (GO:0006099)3.93719328
152-oxoglutarate metabolic process (GO:0006103)3.65181270
16regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.64422067
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.63559849
18L-serine metabolic process (GO:0006563)3.55864344
19regulation of mammary gland epithelial cell proliferation (GO:0033599)3.48533957
20pteridine-containing compound biosynthetic process (GO:0042559)3.44820620
21paraxial mesoderm development (GO:0048339)3.39710373
22GDP-mannose metabolic process (GO:0019673)3.39533772
23lysine metabolic process (GO:0006553)3.34274930
24lysine catabolic process (GO:0006554)3.34274930
25glutamine family amino acid biosynthetic process (GO:0009084)3.33066447
26spliceosomal tri-snRNP complex assembly (GO:0000244)3.31680405
27NADH metabolic process (GO:0006734)3.31130451
28glycine metabolic process (GO:0006544)3.29389866
29mitotic nuclear envelope reassembly (GO:0007084)3.28750790
30nuclear envelope reassembly (GO:0031468)3.28750790
31regulation of translational fidelity (GO:0006450)3.27293209
32dosage compensation (GO:0007549)3.26521989
33guanosine-containing compound biosynthetic process (GO:1901070)3.26482294
34retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.24768971
35energy coupled proton transport, down electrochemical gradient (GO:0015985)3.24502712
36ATP synthesis coupled proton transport (GO:0015986)3.24502712
37nucleobase biosynthetic process (GO:0046112)3.22336738
38negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.18991739
39iron-sulfur cluster assembly (GO:0016226)3.17885788
40metallo-sulfur cluster assembly (GO:0031163)3.17885788
41histone arginine methylation (GO:0034969)3.16779093
42oxaloacetate metabolic process (GO:0006107)3.16201670
43negative regulation of cell size (GO:0045792)3.14573972
44pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.11877576
45Golgi transport vesicle coating (GO:0048200)3.11347198
46COPI coating of Golgi vesicle (GO:0048205)3.11347198
47IMP metabolic process (GO:0046040)3.10806796
48pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.09830582
49fatty acid homeostasis (GO:0055089)3.09111662
50pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.08653881
51ubiquinone metabolic process (GO:0006743)3.08104058
52deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.05837021
53heart contraction (GO:0060047)3.05501115
54heart process (GO:0003015)3.05501115
55glucose catabolic process (GO:0006007)3.05117011
56ribosomal small subunit biogenesis (GO:0042274)3.05049792
57purine nucleobase biosynthetic process (GO:0009113)3.03687328
58biotin metabolic process (GO:0006768)3.02399838
59UTP biosynthetic process (GO:0006228)3.02051257
60pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.01713980
61peptidyl-arginine omega-N-methylation (GO:0035247)3.00668592
62histone H4-K12 acetylation (GO:0043983)3.00205233
63negative regulation of telomerase activity (GO:0051974)2.99023104
64sarcomere organization (GO:0045214)2.98273843
65endothelial cell chemotaxis (GO:0035767)2.96809159
66aspartate family amino acid catabolic process (GO:0009068)2.96550990
67retinal cone cell development (GO:0046549)2.96388174
68L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.95099915
69quinone biosynthetic process (GO:1901663)2.95098888
70ubiquinone biosynthetic process (GO:0006744)2.95098888
71negative regulation of fatty acid biosynthetic process (GO:0045717)2.94833010
72CTP biosynthetic process (GO:0006241)2.92821509
73CTP metabolic process (GO:0046036)2.92821509
74negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.90815756
75adenine nucleotide transport (GO:0051503)2.90654258
76folic acid metabolic process (GO:0046655)2.90600867
77kinetochore assembly (GO:0051382)2.89577701
78GTP biosynthetic process (GO:0006183)2.89481695
79pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.89312177
80UTP metabolic process (GO:0046051)2.85196146
81ribosome biogenesis (GO:0042254)2.84440415
82NADPH regeneration (GO:0006740)2.83452899
83cardiac myofibril assembly (GO:0055003)2.83105260
84regulation of telomerase activity (GO:0051972)2.82470078
85UV protection (GO:0009650)2.82434561
86prostaglandin biosynthetic process (GO:0001516)2.81056441
87prostanoid biosynthetic process (GO:0046457)2.81056441
88long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.80964465
89nucleoside diphosphate biosynthetic process (GO:0009133)2.80918122
90aspartate family amino acid biosynthetic process (GO:0009067)2.80082838
91regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.76625409
92tricarboxylic acid metabolic process (GO:0072350)2.76478125
93regulation of DNA damage checkpoint (GO:2000001)2.76477239
94base-excision repair, AP site formation (GO:0006285)2.76403115
95purine ribonucleotide transport (GO:0015868)2.75824292
96DNA unwinding involved in DNA replication (GO:0006268)2.74076238
97negative regulation of DNA-templated transcription, elongation (GO:0032785)2.74043126
98deoxyribose phosphate biosynthetic process (GO:0046385)2.73722074
992-deoxyribonucleotide biosynthetic process (GO:0009265)2.73722074
100fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.73093085
101dicarboxylic acid biosynthetic process (GO:0043650)2.70310592
102mitochondrial RNA metabolic process (GO:0000959)2.70256415
103protein-DNA complex disassembly (GO:0032986)2.69097758
104nucleosome disassembly (GO:0006337)2.69097758
105pentose metabolic process (GO:0019321)2.68970420
106cardiac muscle contraction (GO:0060048)2.67310727
107kinetochore organization (GO:0051383)2.67186291
108respiratory electron transport chain (GO:0022904)2.66834003
109spliceosomal snRNP assembly (GO:0000387)2.66682873
110oxygen transport (GO:0015671)2.66399463
111ribosomal small subunit assembly (GO:0000028)2.65048810
112regulation of translational termination (GO:0006449)2.64466956
113serine family amino acid catabolic process (GO:0009071)2.63473907
114DNA demethylation (GO:0080111)2.63141705
115tetrahydrofolate metabolic process (GO:0046653)2.63018117
116L-methionine salvage (GO:0071267)2.62763981
117L-methionine biosynthetic process (GO:0071265)2.62763981
118amino acid salvage (GO:0043102)2.62763981
119regulation of coenzyme metabolic process (GO:0051196)2.62721441
120regulation of cofactor metabolic process (GO:0051193)2.62721441
121purine nucleotide transport (GO:0015865)2.62391122
122response to misfolded protein (GO:0051788)2.61669203
123nucleotide salvage (GO:0043173)2.60870299
124fatty acid beta-oxidation (GO:0006635)2.58867999
125regulation of rhodopsin mediated signaling pathway (GO:0022400)2.57905499
126detection of light stimulus involved in sensory perception (GO:0050962)2.57370174
127detection of light stimulus involved in visual perception (GO:0050908)2.57370174
128protein insertion into membrane (GO:0051205)2.57152670
129electron transport chain (GO:0022900)2.56526613
130tRNA aminoacylation (GO:0043039)2.56467282
131amino acid activation (GO:0043038)2.56467282
132regulation of acyl-CoA biosynthetic process (GO:0050812)2.55589295
133regulation of cholesterol metabolic process (GO:0090181)2.55568884
134serine family amino acid metabolic process (GO:0009069)2.55474501
1354-hydroxyproline metabolic process (GO:0019471)2.55152853
136fatty-acyl-CoA biosynthetic process (GO:0046949)2.54049416
137gluconeogenesis (GO:0006094)2.53290966
138pentose-phosphate shunt (GO:0006098)2.53098380
139tRNA aminoacylation for protein translation (GO:0006418)2.52668902
140planar cell polarity pathway involved in neural tube closure (GO:0090179)2.52397808
141layer formation in cerebral cortex (GO:0021819)2.51965945
142pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.50868956
143determination of adult lifespan (GO:0008340)2.49098478
144mitotic nuclear envelope disassembly (GO:0007077)2.49050616
145L-phenylalanine metabolic process (GO:0006558)2.48129025
146erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.48129025
147methionine biosynthetic process (GO:0009086)2.46657176
148imidazole-containing compound metabolic process (GO:0052803)2.46560936
149negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.44875091
150sulfur amino acid biosynthetic process (GO:0000097)2.44864622
151pyrimidine nucleotide catabolic process (GO:0006244)2.43744116
152carnitine shuttle (GO:0006853)2.43404732
153cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.42526617
154rhodopsin mediated signaling pathway (GO:0016056)2.42478799
155pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.41600130
156hexose biosynthetic process (GO:0019319)2.41519182
157branched-chain amino acid catabolic process (GO:0009083)2.41368024
158positive regulation of mitochondrial fission (GO:0090141)2.40973001
159regulation of histone H3-K9 methylation (GO:0051570)2.40956750
160oxidative demethylation (GO:0070989)2.40373571
161regulation of cholesterol biosynthetic process (GO:0045540)2.40116255
162establishment of mitochondrion localization (GO:0051654)2.40105186
163ncRNA 3-end processing (GO:0043628)2.39763007
164folic acid-containing compound metabolic process (GO:0006760)2.39726219
165coenzyme A metabolic process (GO:0015936)2.39179780
166positive regulation of protein sumoylation (GO:0033235)2.38957402
167fatty acid elongation (GO:0030497)2.38053964
168serine family amino acid biosynthetic process (GO:0009070)2.37313144
169regulation of glucose import in response to insulin stimulus (GO:2001273)2.36264179
170semaphorin-plexin signaling pathway (GO:0071526)2.36071569
171thioester biosynthetic process (GO:0035384)2.34915390
172acyl-CoA biosynthetic process (GO:0071616)2.34915390
173neurotransmitter catabolic process (GO:0042135)2.34882146
174type B pancreatic cell proliferation (GO:0044342)2.33981572
175positive regulation of receptor biosynthetic process (GO:0010870)2.33530609
176maintenance of protein localization in organelle (GO:0072595)2.32455421
177regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.31782390
178misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.31187993
179monosaccharide biosynthetic process (GO:0046364)2.30391700
180peptidyl-arginine modification (GO:0018195)2.29844581
181modulation by virus of host morphology or physiology (GO:0019048)2.29773814
182response to testosterone (GO:0033574)2.23966663
183negative regulation of cell cycle G2/M phase transition (GO:1902750)2.23009494

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.51322726
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.67756804
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.75879213
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.59884145
5MYC_18358816_ChIP-ChIP_MESCs_Mouse2.84533124
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.78936018
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.72382060
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.66214253
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.62629382
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.56798644
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.50273648
12PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.49216037
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.47101184
14THAP11_20581084_ChIP-Seq_MESCs_Mouse2.43962887
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.39574009
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.32614705
17CIITA_25753668_ChIP-Seq_RAJI_Human2.25790544
18DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.21931174
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.21103910
20XRN2_22483619_ChIP-Seq_HELA_Human2.15499658
21SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.12347358
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.10358192
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.09741973
24* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08075663
25RARG_19884340_ChIP-ChIP_MEFs_Mouse2.05286232
26NANOG_18555785_ChIP-Seq_MESCs_Mouse2.04194545
27POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.03113838
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.00147136
29TET1_21451524_ChIP-Seq_MESCs_Mouse1.99018345
30ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.98598807
31MYC_22102868_ChIP-Seq_BL_Human1.98174103
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.97671542
33YY1_21170310_ChIP-Seq_MESCs_Mouse1.92363128
34ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.90462305
35* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89884562
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89485440
37FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.84915191
38* RACK7_27058665_Chip-Seq_MCF-7_Human1.82983771
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.82630489
40CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.81843538
41* ELK3_25401928_ChIP-Seq_HUVEC_Human1.81801488
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.80513955
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79114905
44GABP_19822575_ChIP-Seq_HepG2_Human1.78117541
45BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.77271492
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.75582747
47CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.74453114
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.72651539
49ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.72100374
50CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.70352727
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.66090037
52VDR_21846776_ChIP-Seq_THP-1_Human1.64300327
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.64035394
54STAT3_1855785_ChIP-Seq_MESCs_Mouse1.62507248
55NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.62147233
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61285626
57DCP1A_22483619_ChIP-Seq_HELA_Human1.60449295
58ESR1_15608294_ChIP-ChIP_MCF-7_Human1.60264478
59PPARA_22158963_ChIP-Seq_LIVER_Mouse1.58553109
60TP63_17297297_ChIP-ChIP_HaCaT_Human1.56956866
61* SA1_27219007_Chip-Seq_ERYTHROID_Human1.55567508
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54660590
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.53611132
64ELF1_20517297_ChIP-Seq_JURKAT_Human1.53338074
65FOXP3_21729870_ChIP-Seq_TREG_Human1.52284404
66* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49913824
67* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.47806088
68SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.47054079
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.47029078
70HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46400372
71DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.45936222
72VDR_23849224_ChIP-Seq_CD4+_Human1.44539054
73ELF1_17652178_ChIP-ChIP_JURKAT_Human1.42500138
74EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41946737
75RXR_22158963_ChIP-Seq_LIVER_Mouse1.41812632
76TTF2_22483619_ChIP-Seq_HELA_Human1.40841923
77ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.39611021
78* SMC4_20622854_ChIP-Seq_HELA_Human1.39079425
79CTCF_27219007_Chip-Seq_Bcells_Human1.38773256
80ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38693012
81* KDM5A_27292631_Chip-Seq_BREAST_Human1.37633882
82PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37149229
83* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.36772779
84TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35300709
85* E2F1_21310950_ChIP-Seq_MCF-7_Human1.35050010
86MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.34591907
87EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33765010
88ZFP281_18757296_ChIP-ChIP_E14_Mouse1.32932464
89BCL6_27268052_Chip-Seq_Bcells_Human1.31843693
90* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.29903224
91SOX2_18555785_ChIP-Seq_MESCs_Mouse1.29526390
92NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29004852
93CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.28651384
94* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.26247572
95* KDM2B_26808549_Chip-Seq_DND41_Human1.25078269
96SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23913886
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.23520302
98* CREB1_26743006_Chip-Seq_LNCaP_Human1.22371733
99DNAJC2_21179169_ChIP-ChIP_NT2_Human1.21880389
100BCOR_27268052_Chip-Seq_Bcells_Human1.21540219
101* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.20227282
102KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20124108
103* P68_20966046_ChIP-Seq_HELA_Human1.18958009
104SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.18190234
105* CTCF_26484167_Chip-Seq_Bcells_Mouse1.17262708
106RARA_24833708_ChIP-Seq_LIVER_Mouse1.16779635
107SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.16272769
108* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.15450604
109RARB_24833708_ChIP-Seq_LIVER_Mouse1.15418971
110* KDM2B_26808549_Chip-Seq_K562_Human1.15289762
111KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14861866
112TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13971006
113E2F1_20622854_ChIP-Seq_HELA_Human1.13452909
114OCT4_18692474_ChIP-Seq_MEFs_Mouse1.13146301
115TP53_22127205_ChIP-Seq_IMR90_Human1.12183201
116ZNF263_19887448_ChIP-Seq_K562_Human1.11844358
117TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10325138
118SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10070245
119ESR2_21235772_ChIP-Seq_MCF-7_Human1.08774367
120YY1_22570637_ChIP-Seq_MALME-3M_Human1.08673956
121* CTCF_21964334_Chip-Seq_Bcells_Human1.08364798
122CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07136006
123KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06222753
124SRY_22984422_ChIP-ChIP_TESTIS_Rat1.05893532
125SOX2_18692474_ChIP-Seq_MEFs_Mouse1.05412098
126* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04772384
127* AR_21909140_ChIP-Seq_LNCAP_Human1.04753357
128* PHF8_20622854_ChIP-Seq_HELA_Human1.04710402
129CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04141980
130* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02949146
131SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02857875
132CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.02845255
133POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.00841307
134CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99745857
135KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.99559289
136EGR1_19374776_ChIP-ChIP_THP-1_Human0.99380444
137FOXP1_21924763_ChIP-Seq_HESCs_Human0.98186255
138TFEB_21752829_ChIP-Seq_HELA_Human0.98027657
139SOX2_18692474_ChIP-Seq_MESCs_Mouse0.97322294
140NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.97277134
141FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.96737940
142* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.96178619
143MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95624579
144TBX5_21415370_ChIP-Seq_HL-1_Mouse0.95199511
145FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.94443394
146* LXR_22292898_ChIP-Seq_THP-1_Human0.94370698
147TCF3_18692474_ChIP-Seq_MESCs_Mouse0.91423077

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.58299960
2MP0003646_muscle_fatigue3.48632000
3MP0004858_abnormal_nervous_system3.31365439
4MP0005451_abnormal_body_composition3.28409783
5MP0003123_paternal_imprinting3.27085410
6MP0003806_abnormal_nucleotide_metabolis3.02930167
7MP0000537_abnormal_urethra_morphology2.99941784
8MP0005058_abnormal_lysosome_morphology2.79332588
9MP0004084_abnormal_cardiac_muscle2.75478440
10MP0004215_abnormal_myocardial_fiber2.70639988
11MP0010030_abnormal_orbit_morphology2.61367666
12MP0000751_myopathy2.59672424
13MP0005330_cardiomyopathy2.50955080
14MP0004185_abnormal_adipocyte_glucose2.45635123
15MP0005085_abnormal_gallbladder_physiolo2.36767568
16MP0002269_muscular_atrophy2.35299821
17MP0005365_abnormal_bile_salt2.28466048
18MP0003315_abnormal_perineum_morphology2.22778490
19MP0005257_abnormal_intraocular_pressure2.20217384
20MP0003111_abnormal_nucleus_morphology2.16123880
21MP0005551_abnormal_eye_electrophysiolog2.14512473
22MP0002139_abnormal_hepatobiliary_system2.12881239
23MP0009840_abnormal_foam_cell2.12620538
24MP0005360_urolithiasis2.10421553
25MP0003693_abnormal_embryo_hatching2.09851371
26MP0004233_abnormal_muscle_weight2.04901920
27MP0003137_abnormal_impulse_conducting2.03521476
28MP0005623_abnormal_meninges_morphology2.01409278
29MP0005083_abnormal_biliary_tract1.99373948
30MP0004036_abnormal_muscle_relaxation1.99210350
31MP0010094_abnormal_chromosome_stability1.97334793
32MP0006036_abnormal_mitochondrial_physio1.95947169
33MP0008260_abnormal_autophagy1.93371852
34MP0005670_abnormal_white_adipose1.92735974
35MP0004957_abnormal_blastocyst_morpholog1.88962911
36MP0000749_muscle_degeneration1.84321915
37MP0008058_abnormal_DNA_repair1.83664013
38MP0002653_abnormal_ependyma_morphology1.82787081
39MP0002249_abnormal_larynx_morphology1.79234459
40MP0001849_ear_inflammation1.75290712
41MP0002638_abnormal_pupillary_reflex1.67285591
42MP0003011_delayed_dark_adaptation1.61969228
43MP0002877_abnormal_melanocyte_morpholog1.61752847
44MP0006072_abnormal_retinal_apoptosis1.59199551
45MP0005620_abnormal_muscle_contractility1.58204350
46MP0004087_abnormal_muscle_fiber1.57935919
47MP0003942_abnormal_urinary_system1.56187648
48MP0000003_abnormal_adipose_tissue1.55964119
49MP0002127_abnormal_cardiovascular_syste1.54665051
50MP0008789_abnormal_olfactory_epithelium1.52104267
51MP0002332_abnormal_exercise_endurance1.49114223
52MP0001529_abnormal_vocalization1.49007126
53MP0000678_abnormal_parathyroid_gland1.48521359
54MP0002972_abnormal_cardiac_muscle1.46602242
55MP0000750_abnormal_muscle_regeneration1.45166462
56MP0009672_abnormal_birth_weight1.43628472
57MP0009053_abnormal_anal_canal1.43194020
58MP0003705_abnormal_hypodermis_morpholog1.42598930
59MP0005332_abnormal_amino_acid1.42241500
60MP0008932_abnormal_embryonic_tissue1.41513553
61MP0000747_muscle_weakness1.39171827
62MP0005253_abnormal_eye_physiology1.39017979
63MP0000049_abnormal_middle_ear1.38431807
64MP0001730_embryonic_growth_arrest1.38149535
65MP0010630_abnormal_cardiac_muscle1.37200554
66MP0003077_abnormal_cell_cycle1.35863023
67MP0002822_catalepsy1.34894029
68MP0005501_abnormal_skin_physiology1.34512927
69MP0005394_taste/olfaction_phenotype1.32687570
70MP0005499_abnormal_olfactory_system1.32687570
71MP0005266_abnormal_metabolism1.31656072
72MP0010307_abnormal_tumor_latency1.28814245
73MP0002106_abnormal_muscle_physiology1.27609189
74MP0000778_abnormal_nervous_system1.25973002
75MP0000759_abnormal_skeletal_muscle1.25415063
76MP0003567_abnormal_fetal_cardiomyocyte1.24582557
77MP0009384_cardiac_valve_regurgitation1.24154536
78MP0001672_abnormal_embryogenesis/_devel1.23495672
79MP0005380_embryogenesis_phenotype1.23495672
80MP0009278_abnormal_bone_marrow1.20739949
81MP0005171_absent_coat_pigmentation1.20729857
82MP0008961_abnormal_basal_metabolism1.20692634
83MP0005385_cardiovascular_system_phenoty1.20369516
84MP0001544_abnormal_cardiovascular_syste1.20369516
85MP0002234_abnormal_pharynx_morphology1.19898341
86MP0008775_abnormal_heart_ventricle1.17859560
87MP0004859_abnormal_synaptic_plasticity1.17668179
88MP0003656_abnormal_erythrocyte_physiolo1.17604147
89MP0001697_abnormal_embryo_size1.17168210
90MP0001188_hyperpigmentation1.16319047
91MP0002088_abnormal_embryonic_growth/wei1.15379853
92MP0000681_abnormal_thyroid_gland1.13961139
93MP0004085_abnormal_heartbeat1.12204389
94MP0003984_embryonic_growth_retardation1.11815389
95MP0004145_abnormal_muscle_electrophysio1.11794663
96MP0002089_abnormal_postnatal_growth/wei1.10752973
97MP0005319_abnormal_enzyme/_coenzyme1.10520394
98MP0000538_abnormal_urinary_bladder1.10077432
99MP0003119_abnormal_digestive_system1.10072368
100MP0003329_amyloid_beta_deposits1.10040033
101MP0006292_abnormal_olfactory_placode1.09498957
102MP0008007_abnormal_cellular_replicative1.08432760
103MP0000566_synostosis1.08168139
104MP0000467_abnormal_esophagus_morphology1.06969124
105MP0002080_prenatal_lethality1.06691409
106MP0001764_abnormal_homeostasis1.03061674
107MP0005375_adipose_tissue_phenotype1.02359686
108MP0010329_abnormal_lipoprotein_level1.01957469
109MP0003221_abnormal_cardiomyocyte_apopto1.01571995
110MP0006035_abnormal_mitochondrial_morpho1.01263605
111MP0000350_abnormal_cell_proliferation1.00213201
112MP0004272_abnormal_basement_membrane1.00211149
113MP0001293_anophthalmia0.99088273
114MP0001727_abnormal_embryo_implantation0.98689295
115MP0000534_abnormal_ureter_morphology0.98245937
116MP0000462_abnormal_digestive_system0.98023476
117MP0003879_abnormal_hair_cell0.96783488
118MP0003191_abnormal_cellular_cholesterol0.94280237
119MP0004043_abnormal_pH_regulation0.94014626
120MP0004130_abnormal_muscle_cell0.93093710
121MP0005369_muscle_phenotype0.92175635
122MP0004197_abnormal_fetal_growth/weight/0.92153637
123MP0003950_abnormal_plasma_membrane0.92042473
124MP0002085_abnormal_embryonic_tissue0.91866954
125MP0003136_yellow_coat_color0.91516632
126MP0000762_abnormal_tongue_morphology0.91492019
127MP0005220_abnormal_exocrine_pancreas0.91189648
128MP0000266_abnormal_heart_morphology0.88723806
129MP0005666_abnormal_adipose_tissue0.87342401
130MP0000313_abnormal_cell_death0.86623067
131MP0003121_genomic_imprinting0.86255429
132MP0002160_abnormal_reproductive_system0.86158271
133MP0002078_abnormal_glucose_homeostasis0.85905227
134MP0009250_abnormal_appendicular_skeleto0.85839064
135MP0006276_abnormal_autonomic_nervous0.85430951
136MP0004133_heterotaxia0.84698664
137MP0001986_abnormal_taste_sensitivity0.84060201
138MP0005508_abnormal_skeleton_morphology0.83704190
139MP0000026_abnormal_inner_ear0.83267784
140MP0005195_abnormal_posterior_eye0.82955290
141MP0002086_abnormal_extraembryonic_tissu0.82950867
142MP0003385_abnormal_body_wall0.82720522
143MP0002970_abnormal_white_adipose0.82582787
144MP0000733_abnormal_muscle_development0.81536770
145MP0006138_congestive_heart_failure0.81323247
146MP0000609_abnormal_liver_physiology0.80473582
147MP0000358_abnormal_cell_content/0.80298912
148MP0005423_abnormal_somatic_nervous0.79806126
149MP0002084_abnormal_developmental_patter0.79783596
150MP0003634_abnormal_glial_cell0.78112303
151MP0009643_abnormal_urine_homeostasis0.78068021
152MP0003172_abnormal_lysosome_physiology0.77144755
153MP0004019_abnormal_vitamin_homeostasis0.77082044
154MP0000613_abnormal_salivary_gland0.74992699
155MP0002909_abnormal_adrenal_gland0.74469242
156MP0001905_abnormal_dopamine_level0.71958337
157MP0002092_abnormal_eye_morphology0.71915610
158MP0003186_abnormal_redox_activity0.71846608
159MP0003938_abnormal_ear_development0.70849700
160MP0001346_abnormal_lacrimal_gland0.69025507
161MP0000955_abnormal_spinal_cord0.68622885
162MP0002152_abnormal_brain_morphology0.66947721
163MP0002697_abnormal_eye_size0.64919856
164MP0003861_abnormal_nervous_system0.64077055
165MP0000639_abnormal_adrenal_gland0.63420456
166MP0001661_extended_life_span0.62764285
167MP0002114_abnormal_axial_skeleton0.60179402
168MP0010234_abnormal_vibrissa_follicle0.59993402
169MP0002111_abnormal_tail_morphology0.58493139

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)6.40623390
2Hypoglycemic coma (HP:0001325)3.92337961
3Myoglobinuria (HP:0002913)3.87049460
4Ketoacidosis (HP:0001993)3.56901137
5Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.52261296
6Decreased activity of mitochondrial respiratory chain (HP:0008972)3.52261296
7Sudden death (HP:0001699)3.51573331
8Rhabdomyolysis (HP:0003201)3.45272161
9Hyperglycinuria (HP:0003108)3.36774030
10Hyperacusis (HP:0010780)3.34356753
11Broad distal phalanx of finger (HP:0009836)3.32315159
12Abnormal mitochondria in muscle tissue (HP:0008316)3.28541173
13Pseudobulbar signs (HP:0002200)3.17582722
14Achilles tendon contracture (HP:0001771)3.15998972
15Hepatic necrosis (HP:0002605)3.15382381
16Degeneration of anterior horn cells (HP:0002398)3.14951724
17Abnormality of the anterior horn cell (HP:0006802)3.14951724
18Ketosis (HP:0001946)3.11216039
19Vertebral compression fractures (HP:0002953)3.02264080
20Microvesicular hepatic steatosis (HP:0001414)3.00335189
21Ragged-red muscle fibers (HP:0003200)3.00285850
22Acute necrotizing encephalopathy (HP:0006965)2.99026932
23Hyperglycinemia (HP:0002154)2.97507694
24Increased muscle lipid content (HP:0009058)2.96241406
25Pigmentary retinal degeneration (HP:0001146)2.95265447
26Increased intramyocellular lipid droplets (HP:0012240)2.87663386
27Acute encephalopathy (HP:0006846)2.87066123
28Hyperammonemia (HP:0001987)2.84524172
29Cerebral edema (HP:0002181)2.84257885
30Hepatocellular necrosis (HP:0001404)2.81560794
31Myopathic facies (HP:0002058)2.80711267
32Abnormality of glycine metabolism (HP:0010895)2.80208485
33Abnormality of serine family amino acid metabolism (HP:0010894)2.80208485
34Exercise-induced muscle cramps (HP:0003710)2.75605456
35Increased CSF lactate (HP:0002490)2.74437277
36Lactic acidosis (HP:0003128)2.73898736
37Abnormality of the Achilles tendon (HP:0005109)2.72229774
38Increased serum lactate (HP:0002151)2.72184724
39Abnormality of fatty-acid metabolism (HP:0004359)2.71594352
40Ventricular tachycardia (HP:0004756)2.68612227
41Abnormal rod and cone electroretinograms (HP:0008323)2.68550373
42Dicarboxylic aciduria (HP:0003215)2.65378178
43Abnormality of dicarboxylic acid metabolism (HP:0010995)2.65378178
44Short nail (HP:0001799)2.65222516
45Exercise-induced myalgia (HP:0003738)2.62768523
46Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.62607331
47Opisthotonus (HP:0002179)2.61288629
48Generalized aminoaciduria (HP:0002909)2.57484354
49Hyperinsulinemic hypoglycemia (HP:0000825)2.57398487
50Mitochondrial inheritance (HP:0001427)2.56475705
513-Methylglutaconic aciduria (HP:0003535)2.52557659
52Type I transferrin isoform profile (HP:0003642)2.51742977
53Multiple enchondromatosis (HP:0005701)2.50448018
54Upper limb amyotrophy (HP:0009129)2.49788768
55Distal upper limb amyotrophy (HP:0007149)2.49788768
56Insomnia (HP:0100785)2.49133938
57Gout (HP:0001997)2.47424452
58Hypoglycemic seizures (HP:0002173)2.45380823
59Bulbar palsy (HP:0001283)2.45026428
60Palpitations (HP:0001962)2.43255388
61Hand muscle atrophy (HP:0009130)2.40210719
62Late onset (HP:0003584)2.39803057
63Pendular nystagmus (HP:0012043)2.38141718
64Athetosis (HP:0002305)2.35771453
65Oral leukoplakia (HP:0002745)2.35741290
66Unsteady gait (HP:0002317)2.35732055
67Central scotoma (HP:0000603)2.33716671
68Progressive muscle weakness (HP:0003323)2.30144630
69Exercise intolerance (HP:0003546)2.27018656
70Calf muscle hypertrophy (HP:0008981)2.25378692
71Ulnar bowing (HP:0003031)2.24954164
72Dilated cardiomyopathy (HP:0001644)2.23688371
73Abnormality of the distal phalanges of the toes (HP:0010182)2.22660388
74Stridor (HP:0010307)2.21689427
75Myokymia (HP:0002411)2.20612375
76Adducted thumb (HP:0001181)2.18822491
77Abnormality of aromatic amino acid family metabolism (HP:0004338)2.18606903
78Hyperglycemia (HP:0003074)2.15856573
79Sensorimotor neuropathy (HP:0007141)2.13925102
80Limb hypertonia (HP:0002509)2.13404757
81Prolonged neonatal jaundice (HP:0006579)2.12674152
82Respiratory failure (HP:0002878)2.12469965
83Trismus (HP:0000211)2.12357857
84Angiofibromas (HP:0010615)2.10696787
85Adenoma sebaceum (HP:0009720)2.10696787
86Progressive macrocephaly (HP:0004481)2.10287103
87Lethargy (HP:0001254)2.08876796
88Hypoplasia of the capital femoral epiphysis (HP:0003090)2.08715849
89Lipid accumulation in hepatocytes (HP:0006561)2.08297722
90Difficulty climbing stairs (HP:0003551)2.06252220
91Lipoatrophy (HP:0100578)2.03959206
92Abnormal number of erythroid precursors (HP:0012131)2.03638758
93Muscle stiffness (HP:0003552)2.03024190
94Reticulocytosis (HP:0001923)2.01689384
95Retinal dysplasia (HP:0007973)2.01655597
96Abnormality of endocrine pancreas physiology (HP:0012093)2.01392850
97Abnormality of the pancreatic islet cells (HP:0006476)2.01392850
98Cholelithiasis (HP:0001081)2.00613562
99Pancreatic islet-cell hyperplasia (HP:0004510)1.99654801
100Bony spicule pigmentary retinopathy (HP:0007737)1.99298260
101Spinal rigidity (HP:0003306)1.99266665
102Dysphonia (HP:0001618)1.98946597
103Absent rod-and cone-mediated responses on ERG (HP:0007688)1.98868004
104Muscle hypertrophy of the lower extremities (HP:0008968)1.98673348
105Short femoral neck (HP:0100864)1.97980462
106Biconcave vertebral bodies (HP:0004586)1.96542379
107Decreased electroretinogram (ERG) amplitude (HP:0000654)1.95102264
108Microretrognathia (HP:0000308)1.94848219
109Down-sloping shoulders (HP:0200021)1.92888679
110Muscle fiber atrophy (HP:0100295)1.92308198
111Abnormality of cells of the erythroid lineage (HP:0012130)1.92144907
112Overriding aorta (HP:0002623)1.91887256
113Long palpebral fissure (HP:0000637)1.91609454
114Delayed CNS myelination (HP:0002188)1.90175018
115Optic disc pallor (HP:0000543)1.90081203
116Elfin facies (HP:0004428)1.89424595
117Aplasia/Hypoplasia of the sacrum (HP:0008517)1.89136713
118Cerebral palsy (HP:0100021)1.88967114
119Atrial fibrillation (HP:0005110)1.88291958
120Abnormal gallbladder morphology (HP:0012437)1.87985533
121Thin bony cortex (HP:0002753)1.87874917
122Testicular atrophy (HP:0000029)1.87482498
123Double outlet right ventricle (HP:0001719)1.86907213
124Congenital malformation of the right heart (HP:0011723)1.86907213
125Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.86531583
126Abnormality of alanine metabolism (HP:0010916)1.86531583
127Hyperalaninemia (HP:0003348)1.86531583
128Cerebral hypomyelination (HP:0006808)1.86315432
129Emotional lability (HP:0000712)1.85767932
130Shallow orbits (HP:0000586)1.85225888
131Protrusio acetabuli (HP:0003179)1.85089842
132Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.84916440
133Myotonia (HP:0002486)1.84859216
134Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.84298928
135Absent epiphyses (HP:0010577)1.84298928
136Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.84283134
137Abnormality of glycolysis (HP:0004366)1.84139049
138Increased serum pyruvate (HP:0003542)1.84139049
139Areflexia of lower limbs (HP:0002522)1.83875540
140Abnormality of serum amino acid levels (HP:0003112)1.83614299
141Anal stenosis (HP:0002025)1.83570700
142Premature rupture of membranes (HP:0001788)1.83381544
143Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.82991917
144Abnormal protein N-linked glycosylation (HP:0012347)1.82991917
145Abnormal protein glycosylation (HP:0012346)1.82991917
146Abnormal glycosylation (HP:0012345)1.82991917
147Supraventricular tachycardia (HP:0004755)1.82711022
148Glossoptosis (HP:0000162)1.82498182
149CNS demyelination (HP:0007305)1.82481363
150Abnormality of the parathyroid morphology (HP:0011766)1.82423506
151Increased hepatocellular lipid droplets (HP:0006565)1.82131033
152Abnormality of the aortic arch (HP:0012303)1.80769147
153Abnormality of reticulocytes (HP:0004312)1.79859616
154Vomiting (HP:0002013)1.78176867
155Nausea (HP:0002018)1.78166588
156Renal duplication (HP:0000075)1.77919288
157Intestinal fistula (HP:0100819)1.77648061
158Flattened epiphyses (HP:0003071)1.77067037
159Centrally nucleated skeletal muscle fibers (HP:0003687)1.77022151
160Turricephaly (HP:0000262)1.76546184
161Supraventricular arrhythmia (HP:0005115)1.74729961
162Metabolic acidosis (HP:0001942)1.74225948
163Congenital glaucoma (HP:0001087)1.73752711
164Abnormal gallbladder physiology (HP:0012438)1.72852538
165Cholecystitis (HP:0001082)1.72852538
166Distal lower limb muscle weakness (HP:0009053)1.72471753
167Neonatal onset (HP:0003623)1.70830055
168Precocious puberty (HP:0000826)1.68930075
169Back pain (HP:0003418)1.68237456
170Spastic paraparesis (HP:0002313)1.67579621
171Truncus arteriosus (HP:0001660)1.67077158
172Patellar dislocation (HP:0002999)1.66774087
173Distal lower limb amyotrophy (HP:0008944)1.66026722
174Pointed chin (HP:0000307)1.65344227
175Ankle clonus (HP:0011448)1.65235817
176High anterior hairline (HP:0009890)1.64657204
177Facial cleft (HP:0002006)1.64392543
178Cervical subluxation (HP:0003308)1.62538978
179Easy fatigability (HP:0003388)1.61261146
180Mitral regurgitation (HP:0001653)1.60248667
181Renovascular hypertension (HP:0100817)1.60052722
182Abnormality of the gallbladder (HP:0005264)1.58085493
183Abnormality of the lower motor neuron (HP:0002366)1.57501699
184Dry hair (HP:0011359)1.57237895

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.36056885
2EIF2AK14.01651179
3TRIB33.79189713
4NEK13.34937504
5EPHA23.25898596
6TLK13.05611146
7TESK13.05161621
8PIM23.03603738
9PKN22.78257260
10FLT32.64222563
11MAP3K102.59842535
12SRPK12.36408378
13PRKD32.29549684
14ARAF2.27532373
15ZAK2.19909328
16IRAK32.18616386
17CDK122.02928317
18TTN1.99805463
19CDC71.86498112
20CCNB11.84487742
21OBSCN1.70971898
22INSRR1.59363955
23RPS6KB21.56684770
24EEF2K1.55809725
25SMG11.55782914
26NME21.52039176
27LIMK11.49197124
28BRD41.45137910
29TSSK61.43593249
30VRK21.42978993
31EPHB21.39038141
32PRKD21.38142986
33NME11.36635479
34STK38L1.35700022
35MYLK1.34526977
36AKT31.33314648
37DAPK31.32010849
38CDK71.30419073
39AURKA1.27411581
40DYRK31.25743433
41ILK1.25229091
42PHKG11.25125930
43PHKG21.25125930
44LATS21.22061039
45PTK21.21690363
46SCYL21.19839909
47MAPKAPK31.14094360
48NTRK11.12413753
49MAP2K71.12380454
50TESK21.11644318
51BUB11.11516395
52NEK21.11374280
53CHEK21.09920232
54PINK11.06727333
55PNCK1.06261814
56STK41.03730341
57PRKCI1.03691594
58CSNK1G31.03248917
59LATS11.02996128
60WNK31.02286021
61MET1.02166270
62TAOK21.01031333
63RPS6KA21.00662524
64ABL21.00601846
65TNK21.00494506
66PLK10.98367164
67PAK40.97924789
68IRAK20.92960045
69CDK190.92613754
70ATR0.92051308
71TAOK10.91899955
72PRPF4B0.87440446
73TTK0.87380624
74AURKB0.87284245
75PLK40.86922527
76UHMK10.86761831
77CSNK1A1L0.86620189
78CDK40.86507675
79GRK60.85437138
80DAPK10.83990734
81LMTK20.83545421
82MKNK10.80783843
83WEE10.79827981
84WNK40.78612211
85ERN10.77980192
86LRRK20.75931332
87DYRK1B0.75637543
88BRAF0.74703340
89PAK60.73566243
90PRKAA10.72463409
91MAP2K20.71937920
92CDK80.71877329
93STK160.71525761
94CAMKK10.70389282
95CHEK10.70313546
96KDR0.70068456
97EIF2AK20.68369201
98RPS6KA40.68086824
99AKT20.67680036
100CDK140.64628672
101CDK20.64544955
102RPS6KA50.63193040
103SIK10.62134075
104CDK11A0.61902836
105CAMK2G0.61120566
106EPHB10.59235108
107MAP3K130.58234785
108RIPK10.57722770
109CSNK1G20.57026361
110CSNK1G10.56187805
111VRK10.56060800
112MAP3K70.55598578
113CDK150.55035369
114MAP3K110.53809331
115ATM0.53187098
116YES10.52777640
117PRKDC0.52711144
118PRKAA20.52027981
119PTK60.51543800
120MAP2K40.51412330
121MST1R0.51155635
122RPS6KC10.51082294
123RPS6KL10.51082294
124MAPK110.50061811
125SGK20.50015059
126ALK0.49188341
127CDK180.49104728
128CSNK2A20.48496198
129PAK20.48274353
130MAP2K30.47695835
131MAPK150.46661454
132MKNK20.45841418
133IRAK40.45605900
134BRSK10.45217389
135PIK3CG0.44046356
136MTOR0.43351389
137PRKCZ0.43203227
138CDK90.43163616
139SIK20.42818924
140DYRK20.42163090
141TYK20.42020550
142CAMK10.41940104
143CAMK40.41086219
144RPS6KA10.40825526
145TIE10.40701631
146PDPK10.40271351
147MUSK0.40193422
148CAMK1G0.39276217
149CDK10.38480546
150GRK10.37122969
151PLK30.36921163
152MAP3K80.36352018
153CAMK1D0.35420781
154AKT10.34946606
155PRKACB0.34091478
156ICK0.33898702
157CSNK1E0.33655257

Predicted pathways (KEGG)

RankGene SetZ-score
12-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.60789004
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.55249789
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.35726474
4Phototransduction_Homo sapiens_hsa047442.88453437
5One carbon pool by folate_Homo sapiens_hsa006702.53784211
6Carbon metabolism_Homo sapiens_hsa012002.37125315
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.32284402
8Biosynthesis of amino acids_Homo sapiens_hsa012302.29205956
9Oxidative phosphorylation_Homo sapiens_hsa001902.19654029
10Steroid biosynthesis_Homo sapiens_hsa001002.18012839
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.15295221
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.13329096
13Propanoate metabolism_Homo sapiens_hsa006402.03942864
14Fatty acid degradation_Homo sapiens_hsa000712.02923788
15Parkinsons disease_Homo sapiens_hsa050121.96795094
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.93483422
17Arginine biosynthesis_Homo sapiens_hsa002201.81601894
18Cardiac muscle contraction_Homo sapiens_hsa042601.80695723
19Sulfur relay system_Homo sapiens_hsa041221.77150896
20DNA replication_Homo sapiens_hsa030301.72797357
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.71373652
22Pyruvate metabolism_Homo sapiens_hsa006201.68916741
23Lysine degradation_Homo sapiens_hsa003101.68159333
24Non-homologous end-joining_Homo sapiens_hsa034501.68072169
25Spliceosome_Homo sapiens_hsa030401.64062450
26Folate biosynthesis_Homo sapiens_hsa007901.57814524
27Ribosome_Homo sapiens_hsa030101.55699882
28Mismatch repair_Homo sapiens_hsa034301.51879439
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.51766168
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49639706
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.46109533
32RNA transport_Homo sapiens_hsa030131.45838961
33Tryptophan metabolism_Homo sapiens_hsa003801.45570932
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.45095212
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.44893235
36Fatty acid biosynthesis_Homo sapiens_hsa000611.44715422
37RNA polymerase_Homo sapiens_hsa030201.43354333
38Systemic lupus erythematosus_Homo sapiens_hsa053221.41742259
39Phenylalanine metabolism_Homo sapiens_hsa003601.40895677
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.36790574
41Fructose and mannose metabolism_Homo sapiens_hsa000511.36739815
42Vitamin B6 metabolism_Homo sapiens_hsa007501.36623923
43Fatty acid metabolism_Homo sapiens_hsa012121.35023327
44Butanoate metabolism_Homo sapiens_hsa006501.34777987
45Huntingtons disease_Homo sapiens_hsa050161.34688956
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.30781333
47* Peroxisome_Homo sapiens_hsa041461.26028395
48Alzheimers disease_Homo sapiens_hsa050101.23240411
49Pentose phosphate pathway_Homo sapiens_hsa000301.23066031
50Other glycan degradation_Homo sapiens_hsa005111.22487533
51Base excision repair_Homo sapiens_hsa034101.21260778
52Primary bile acid biosynthesis_Homo sapiens_hsa001201.19739353
53Arginine and proline metabolism_Homo sapiens_hsa003301.15622683
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13855408
55Glutathione metabolism_Homo sapiens_hsa004801.11409649
56Pyrimidine metabolism_Homo sapiens_hsa002401.11073959
57N-Glycan biosynthesis_Homo sapiens_hsa005101.10505548
58Vibrio cholerae infection_Homo sapiens_hsa051101.09378703
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.08731253
60Homologous recombination_Homo sapiens_hsa034401.08588088
61Selenocompound metabolism_Homo sapiens_hsa004501.04715669
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98119554
63Fat digestion and absorption_Homo sapiens_hsa049750.95050576
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94862344
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.93948811
66beta-Alanine metabolism_Homo sapiens_hsa004100.93455531
67Galactose metabolism_Homo sapiens_hsa000520.81705228
68Basal cell carcinoma_Homo sapiens_hsa052170.80122998
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79990541
70Fanconi anemia pathway_Homo sapiens_hsa034600.78648982
71RNA degradation_Homo sapiens_hsa030180.77256049
72Starch and sucrose metabolism_Homo sapiens_hsa005000.77122845
73Proteasome_Homo sapiens_hsa030500.76894333
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76732644
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76087382
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.73358398
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.71826120
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70496749
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.69246877
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.68377905
81Metabolic pathways_Homo sapiens_hsa011000.68291617
82mRNA surveillance pathway_Homo sapiens_hsa030150.67077909
83Purine metabolism_Homo sapiens_hsa002300.66536291
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65805195
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65390449
86Tyrosine metabolism_Homo sapiens_hsa003500.63883532
87Hippo signaling pathway_Homo sapiens_hsa043900.62182849
88PPAR signaling pathway_Homo sapiens_hsa033200.61158002
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57382024
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57200629
91Alcoholism_Homo sapiens_hsa050340.56133018
92Glycerolipid metabolism_Homo sapiens_hsa005610.55200367
93Glucagon signaling pathway_Homo sapiens_hsa049220.53459115
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53111929
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50590441
96Nucleotide excision repair_Homo sapiens_hsa034200.48493667
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47807983
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45988665
99Cell cycle_Homo sapiens_hsa041100.44762191
100Hedgehog signaling pathway_Homo sapiens_hsa043400.44304618
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44077109
102Dilated cardiomyopathy_Homo sapiens_hsa054140.43750494
103Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42503311
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42303530
105Insulin signaling pathway_Homo sapiens_hsa049100.40935456
106Axon guidance_Homo sapiens_hsa043600.40596409
107VEGF signaling pathway_Homo sapiens_hsa043700.40167353
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39171232
109Fatty acid elongation_Homo sapiens_hsa000620.38811047
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38226606
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37266783
112Bladder cancer_Homo sapiens_hsa052190.35739261
113Prion diseases_Homo sapiens_hsa050200.34923146
114Melanogenesis_Homo sapiens_hsa049160.34879365
115Chronic myeloid leukemia_Homo sapiens_hsa052200.34582533
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.33666752
117Endocytosis_Homo sapiens_hsa041440.33342995
118Synaptic vesicle cycle_Homo sapiens_hsa047210.31529505
119Notch signaling pathway_Homo sapiens_hsa043300.31510719
120ABC transporters_Homo sapiens_hsa020100.31509010
121Insulin resistance_Homo sapiens_hsa049310.30288468
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29816683
123Glioma_Homo sapiens_hsa052140.27996229
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.27850029
125Non-small cell lung cancer_Homo sapiens_hsa052230.27511297
126Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27204481
127Bile secretion_Homo sapiens_hsa049760.26361517
128AMPK signaling pathway_Homo sapiens_hsa041520.23039237
129Thyroid cancer_Homo sapiens_hsa052160.19221469
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16112856
131Acute myeloid leukemia_Homo sapiens_hsa052210.16104729
132mTOR signaling pathway_Homo sapiens_hsa041500.15982024

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