PEX11A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the PEX11 family, which is composed of membrane elongation factors involved in regulation of peroxisome maintenance and proliferation. This gene product interacts with peroxisomal membrane protein 19 and may respond to outside stimuli to increase peroxisome abundance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.01457394
2L-phenylalanine catabolic process (GO:0006559)7.01457394
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.80866269
4L-phenylalanine metabolic process (GO:0006558)6.80866269
5aromatic amino acid family catabolic process (GO:0009074)6.30006351
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.18996971
7alpha-linolenic acid metabolic process (GO:0036109)5.98832037
8indole-containing compound catabolic process (GO:0042436)5.65275978
9indolalkylamine catabolic process (GO:0046218)5.65275978
10tryptophan catabolic process (GO:0006569)5.65275978
11sulfur amino acid catabolic process (GO:0000098)5.61555291
12kynurenine metabolic process (GO:0070189)5.58501941
13bile acid biosynthetic process (GO:0006699)5.43715749
14glyoxylate metabolic process (GO:0046487)5.41136395
15tryptophan metabolic process (GO:0006568)5.34075545
16urea cycle (GO:0000050)5.26879671
17urea metabolic process (GO:0019627)5.26879671
18cysteine metabolic process (GO:0006534)5.24020337
19coenzyme catabolic process (GO:0009109)5.08397860
20high-density lipoprotein particle remodeling (GO:0034375)5.05304755
21fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.04928744
22serine family amino acid catabolic process (GO:0009071)4.99412836
23nitrogen cycle metabolic process (GO:0071941)4.91918973
24lysine catabolic process (GO:0006554)4.88014267
25lysine metabolic process (GO:0006553)4.88014267
26regulation of triglyceride catabolic process (GO:0010896)4.87007556
27negative regulation of fibrinolysis (GO:0051918)4.75711916
28bile acid metabolic process (GO:0008206)4.69423114
29protein carboxylation (GO:0018214)4.68809414
30peptidyl-glutamic acid carboxylation (GO:0017187)4.68809414
31amino-acid betaine metabolic process (GO:0006577)4.67615650
32cellular modified amino acid catabolic process (GO:0042219)4.64714729
33complement activation, alternative pathway (GO:0006957)4.61535732
34aromatic amino acid family metabolic process (GO:0009072)4.60993349
35regulation of fibrinolysis (GO:0051917)4.54543634
36homocysteine metabolic process (GO:0050667)4.52899510
37cellular ketone body metabolic process (GO:0046950)4.52079283
38triglyceride homeostasis (GO:0070328)4.51860138
39acylglycerol homeostasis (GO:0055090)4.51860138
40alpha-amino acid catabolic process (GO:1901606)4.51315530
41regulation of protein activation cascade (GO:2000257)4.51218579
42regulation of cholesterol esterification (GO:0010872)4.50498719
43reverse cholesterol transport (GO:0043691)4.44206138
44tyrosine metabolic process (GO:0006570)4.38132235
45plasma lipoprotein particle remodeling (GO:0034369)4.37573931
46protein-lipid complex remodeling (GO:0034368)4.37573931
47macromolecular complex remodeling (GO:0034367)4.37573931
48negative regulation of cholesterol transport (GO:0032375)4.33300629
49negative regulation of sterol transport (GO:0032372)4.33300629
50cellular amino acid catabolic process (GO:0009063)4.30909656
51epoxygenase P450 pathway (GO:0019373)4.28235618
52phospholipid efflux (GO:0033700)4.25699627
53regulation of complement activation (GO:0030449)4.20554191
54plasma lipoprotein particle clearance (GO:0034381)4.16335223
55glycine metabolic process (GO:0006544)4.15107783
56drug catabolic process (GO:0042737)4.14450514
57serine family amino acid metabolic process (GO:0009069)4.04875519
58indolalkylamine metabolic process (GO:0006586)3.99865684
59ethanol oxidation (GO:0006069)3.98370350
60short-chain fatty acid metabolic process (GO:0046459)3.94664677
61bile acid and bile salt transport (GO:0015721)3.94468542
62glutamate metabolic process (GO:0006536)3.94039078
63acetyl-CoA metabolic process (GO:0006084)3.93277448
64cofactor catabolic process (GO:0051187)3.92339200
65ketone body metabolic process (GO:1902224)3.89951434
66fatty acid beta-oxidation (GO:0006635)3.88101540
67drug metabolic process (GO:0017144)3.87864546
68cellular glucuronidation (GO:0052695)3.87000623
69carboxylic acid catabolic process (GO:0046395)3.86802976
70organic acid catabolic process (GO:0016054)3.86802976
71valine metabolic process (GO:0006573)3.85007329
72positive regulation of lipid catabolic process (GO:0050996)3.83785012
73benzene-containing compound metabolic process (GO:0042537)3.82547935
74amine catabolic process (GO:0009310)3.81195264
75cellular biogenic amine catabolic process (GO:0042402)3.81195264
76fatty acid oxidation (GO:0019395)3.77648037
77dicarboxylic acid biosynthetic process (GO:0043650)3.75890652
78imidazole-containing compound metabolic process (GO:0052803)3.75745853
79cholesterol efflux (GO:0033344)3.74778462
80positive regulation of fatty acid beta-oxidation (GO:0032000)3.74690230
81positive regulation of triglyceride lipase activity (GO:0061365)3.74551106
82positive regulation of lipoprotein lipase activity (GO:0051006)3.74551106
83biotin metabolic process (GO:0006768)3.74229324
84flavonoid metabolic process (GO:0009812)3.70946333
85regulation of cholesterol homeostasis (GO:2000188)3.70874242
86lipid oxidation (GO:0034440)3.70711809
87serine family amino acid biosynthetic process (GO:0009070)3.68653315
88fatty acid catabolic process (GO:0009062)3.68142375
89monocarboxylic acid catabolic process (GO:0072329)3.66668165
902-oxoglutarate metabolic process (GO:0006103)3.65383319
91branched-chain amino acid catabolic process (GO:0009083)3.64133185
92negative regulation of lipase activity (GO:0060192)3.62804477
93behavioral response to nicotine (GO:0035095)3.62284182
94carnitine metabolic process (GO:0009437)3.62004282
95arginine metabolic process (GO:0006525)3.61277935
96plasma lipoprotein particle assembly (GO:0034377)3.59419664
97aspartate family amino acid catabolic process (GO:0009068)3.58011559
98exogenous drug catabolic process (GO:0042738)3.56663340
99glycerol metabolic process (GO:0006071)3.56100234
100cholesterol homeostasis (GO:0042632)3.54179713
101regulation of bile acid biosynthetic process (GO:0070857)3.51646095
102phospholipid homeostasis (GO:0055091)3.49473982
103water-soluble vitamin biosynthetic process (GO:0042364)3.49180825
104platelet dense granule organization (GO:0060155)3.40952128
105respiratory chain complex IV assembly (GO:0008535)3.24218897
106alditol metabolic process (GO:0019400)3.23398186
107epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.22342516
108mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.13822686
109epithelial cilium movement (GO:0003351)3.11918490
110preassembly of GPI anchor in ER membrane (GO:0016254)3.07712209
111regulation of cilium movement (GO:0003352)3.04676540
112protein complex biogenesis (GO:0070271)3.03344228
113cytochrome complex assembly (GO:0017004)2.98477800
114piRNA metabolic process (GO:0034587)2.94666125
115phenylpropanoid metabolic process (GO:0009698)2.86913888
116primary alcohol metabolic process (GO:0034308)2.84571320
117nonmotile primary cilium assembly (GO:0035058)2.84257796
118mitochondrial respiratory chain complex assembly (GO:0033108)2.82593296
119regulation of sequestering of triglyceride (GO:0010889)2.81833950
120positive regulation of mitochondrial fission (GO:0090141)2.80769501
121ubiquinone biosynthetic process (GO:0006744)2.80675493
122S-adenosylmethionine metabolic process (GO:0046500)2.79834032
123oxidative demethylation (GO:0070989)2.79748347
124quinone metabolic process (GO:1901661)2.77230994
125retinol metabolic process (GO:0042572)2.76989721
126regulation of glucokinase activity (GO:0033131)2.74630953
127regulation of hexokinase activity (GO:1903299)2.74630953
128intraciliary transport (GO:0042073)2.72748467
129protein polyglutamylation (GO:0018095)2.72264762
130C-terminal protein lipidation (GO:0006501)2.69599459
131axoneme assembly (GO:0035082)2.66923721
132protein-cofactor linkage (GO:0018065)2.65631784
133ubiquinone metabolic process (GO:0006743)2.63829055
134cilium movement (GO:0003341)2.63620532
135adaptation of signaling pathway (GO:0023058)2.63602581
136polyketide metabolic process (GO:0030638)2.63460687
137doxorubicin metabolic process (GO:0044598)2.63460687
138daunorubicin metabolic process (GO:0044597)2.63460687
139RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.62593262
140tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.62593262
141electron transport chain (GO:0022900)2.62523875
142establishment of protein localization to mitochondrial membrane (GO:0090151)2.62423432
143detection of light stimulus involved in visual perception (GO:0050908)2.62277090
144detection of light stimulus involved in sensory perception (GO:0050962)2.62277090
145lipid particle organization (GO:0034389)2.59358857
146quinone biosynthetic process (GO:1901663)2.58967940
147mannosylation (GO:0097502)2.58947945
148cilium morphogenesis (GO:0060271)2.58867513
149mitochondrial respiratory chain complex I assembly (GO:0032981)2.57494488
150NADH dehydrogenase complex assembly (GO:0010257)2.57494488
151mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.57494488
152respiratory electron transport chain (GO:0022904)2.57247767
153aminoglycoside antibiotic metabolic process (GO:0030647)2.56998764
154mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.56933619
155GPI anchor metabolic process (GO:0006505)2.55376739
156cilium organization (GO:0044782)2.55273264
157white fat cell differentiation (GO:0050872)2.54016575
158energy coupled proton transport, down electrochemical gradient (GO:0015985)2.53794780
159ATP synthesis coupled proton transport (GO:0015986)2.53794780
160cilium assembly (GO:0042384)2.53149611
161retinal metabolic process (GO:0042574)2.51403794
162photoreceptor cell maintenance (GO:0045494)2.49939453
163pyrimidine nucleobase catabolic process (GO:0006208)2.49840953
164C-terminal protein amino acid modification (GO:0018410)2.46582138
165branched-chain amino acid metabolic process (GO:0009081)2.45184701
166nucleobase catabolic process (GO:0046113)2.44447974
167arginine catabolic process (GO:0006527)2.44366687
168positive regulation of glycolytic process (GO:0045821)2.42950836
169dopamine transport (GO:0015872)2.42769654
170fatty acid homeostasis (GO:0055089)2.42531575
171auditory receptor cell differentiation (GO:0042491)2.40198618
172GPI anchor biosynthetic process (GO:0006506)2.39694114
173response to nitrosative stress (GO:0051409)2.39064924
174axonemal dynein complex assembly (GO:0070286)2.38309490

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.12087765
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.99531006
3LXR_22158963_ChIP-Seq_LIVER_Mouse6.27336073
4EGR1_23403033_ChIP-Seq_LIVER_Mouse6.19317855
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.05928781
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.15194432
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.58298115
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.97945535
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.67223420
10ZNF274_21170338_ChIP-Seq_K562_Hela3.09903823
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.69123744
12VDR_22108803_ChIP-Seq_LS180_Human2.60277889
13EZH2_22144423_ChIP-Seq_EOC_Human2.59745137
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.56515507
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.38645499
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.37079847
17IGF1R_20145208_ChIP-Seq_DFB_Human2.34534177
18GBX2_23144817_ChIP-Seq_PC3_Human2.27709544
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.26843874
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25198867
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16890904
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.05963617
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.1013075
24HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.88599068
25FUS_26573619_Chip-Seq_HEK293_Human1.84588013
26TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.83484528
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.82355848
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.82267081
29ER_23166858_ChIP-Seq_MCF-7_Human1.77448189
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.73353561
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71895412
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.68213607
33EWS_26573619_Chip-Seq_HEK293_Human1.67484523
34CLOCK_20551151_ChIP-Seq_293T_Human1.64806539
35P300_19829295_ChIP-Seq_ESCs_Human1.62402347
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61247795
37CBP_20019798_ChIP-Seq_JUKART_Human1.57454459
38IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.57454459
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.53075311
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52456273
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.51994890
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46515600
43FOXA2_19822575_ChIP-Seq_HepG2_Human1.46317234
44TP53_22573176_ChIP-Seq_HFKS_Human1.46104759
45HNF4A_19822575_ChIP-Seq_HepG2_Human1.41445655
46AR_25329375_ChIP-Seq_VCAP_Human1.40317536
47TAF15_26573619_Chip-Seq_HEK293_Human1.39708796
48STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.37219342
49* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36937405
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.34306140
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34055326
52BCAT_22108803_ChIP-Seq_LS180_Human1.33614201
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31181258
54JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.30808026
55ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.30555114
56TCF4_22108803_ChIP-Seq_LS180_Human1.30479148
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.30046944
58GATA1_22025678_ChIP-Seq_K562_Human1.29674115
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29501964
60NCOR_22424771_ChIP-Seq_293T_Human1.27415710
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27390528
62RXRA_24833708_ChIP-Seq_LIVER_Mouse1.26734184
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26379830
64NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.26021363
65BP1_19119308_ChIP-ChIP_Hs578T_Human1.25170023
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23569202
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.23212534
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23001925
69SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22851762
70STAT3_23295773_ChIP-Seq_U87_Human1.22713443
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22338787
72FOXA1_27270436_Chip-Seq_PROSTATE_Human1.22236579
73FOXA1_25329375_ChIP-Seq_VCAP_Human1.22236579
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22220445
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22172686
76CDX2_22108803_ChIP-Seq_LS180_Human1.21842096
77KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.21454030
78KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.21454030
79KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.21454030
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20039720
81EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19493472
82SMAD4_21799915_ChIP-Seq_A2780_Human1.19053511
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17374146
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17360112
85ETS1_20019798_ChIP-Seq_JURKAT_Human1.16978603
86NANOG_19829295_ChIP-Seq_ESCs_Human1.16360422
87SOX2_19829295_ChIP-Seq_ESCs_Human1.16360422
88CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15526844
89NFE2_27457419_Chip-Seq_LIVER_Mouse1.14633060
90HTT_18923047_ChIP-ChIP_STHdh_Human1.13749331
91FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13241634
92MYC_18940864_ChIP-ChIP_HL60_Human1.11148582
93ELK1_19687146_ChIP-ChIP_HELA_Human1.10962978
94GATA3_21878914_ChIP-Seq_MCF-7_Human1.10848623
95RUNX2_22187159_ChIP-Seq_PCA_Human1.10051747
96STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09731227
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09438860
98TCF4_23295773_ChIP-Seq_U87_Human1.08388649
99PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08224584
100EZH2_27294783_Chip-Seq_NPCs_Mouse1.07540072
101SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06655554
102OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06242353
103ESR2_21235772_ChIP-Seq_MCF-7_Human1.06185480
104SMAD3_21741376_ChIP-Seq_EPCs_Human1.05831489
105BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05017146
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04893652
107TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02128702
108RNF2_27304074_Chip-Seq_NSC_Mouse1.01857953
109CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.01855583
110GATA4_25053715_ChIP-Seq_YYC3_Human1.00724008
111HOXB7_26014856_ChIP-Seq_BT474_Human1.00714804
112ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00437767
113NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.98301319
114PHF8_20622853_ChIP-Seq_HELA_Human0.97935947
115CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.97828528
116PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97266866
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96299877
118SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96078600
119VDR_23849224_ChIP-Seq_CD4+_Human0.95851421
120NANOG_18555785_Chip-Seq_ESCs_Mouse0.95734006
121ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95542608
122TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95257315
123P53_22387025_ChIP-Seq_ESCs_Mouse0.95198337
124POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94172958
125CRX_20693478_ChIP-Seq_RETINA_Mouse0.94125790
126FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92940152
127ELF1_17652178_ChIP-ChIP_JURKAT_Human0.92782996
128FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92474066
129TAL1_26923725_Chip-Seq_HPCs_Mouse0.92231961
130CDX2_20551321_ChIP-Seq_CACO-2_Human0.84942877
131BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.84931844
132KAP1_22055183_ChIP-Seq_ESCs_Mouse0.80201640
133AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79520930
134ESR1_15608294_ChIP-ChIP_MCF-7_Human0.78948821
135FOXO3_23340844_ChIP-Seq_DLD1_Human0.76334379
136RARA_24833708_ChIP-Seq_LIVER_Mouse0.76169400
137SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75164977
138RARG_19884340_ChIP-ChIP_MEFs_Mouse0.74490302
139SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.74449416
140RARB_24833708_ChIP-Seq_LIVER_Mouse0.71321676
141PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.70757228
142TCF3_18692474_ChIP-Seq_MEFs_Mouse0.69828800
143ESET_19884257_ChIP-Seq_ESCs_Mouse0.67293342
144AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.67032738
145ZNF263_19887448_ChIP-Seq_K562_Human0.66306126
146SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.65492319
147ESR1_21235772_ChIP-Seq_MCF-7_Human0.65095591
148* LXR_22292898_ChIP-Seq_THP-1_Human0.64554341
149CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.64213347
150IRF1_19129219_ChIP-ChIP_H3396_Human0.63931003
151NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.63559948
152GATA6_25053715_ChIP-Seq_YYC3_Human0.61055157
153TCF3_18692474_ChIP-Seq_MESCs_Mouse0.60942272
154SALL4_18804426_ChIP-ChIP_XEN_Mouse0.60304447
155IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.59786740
156ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.59752273
157ESR1_20079471_ChIP-ChIP_T-47D_Human0.59435111
158FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.58677532
159RAD21_21589869_ChIP-Seq_MESCs_Mouse0.57865558
160POU5F1_16518401_ChIP-PET_MESCs_Mouse0.56128379
161PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.55984699
162PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.55652335
163CEBPB_22108803_ChIP-Seq_LS180_Human0.54603862
164NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.54068844
165SPI1_26923725_Chip-Seq_HPCs_Mouse0.53989190
166CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.53964434
167Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.53765277
168BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.53750194
169GATA3_24758297_ChIP-Seq_MCF-7_Human0.53044465
170NANOG_16518401_ChIP-PET_MESCs_Mouse0.52804335
171* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.52083886
172STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.52068773
173RACK7_27058665_Chip-Seq_MCF-7_Human0.51560680
174FOXA1_25552417_ChIP-Seq_VCAP_Human0.51228702
175CSB_26484114_Chip-Seq_FIBROBLAST_Human0.50786572
176PPAR_26484153_Chip-Seq_NCI-H1993_Human0.50142671
177FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.49197499
178BCOR_27268052_Chip-Seq_Bcells_Human0.49147208
179AR_20517297_ChIP-Seq_VCAP_Human0.49141996
180OCT4_18692474_ChIP-Seq_MEFs_Mouse0.48112035
181NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.47781536
182GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.47116111
183P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.46365006
184* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.46144317
185SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.46034307
186MYC_27129775_Chip-Seq_CORNEA_Mouse0.45434120
187SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.45092135
188SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.44199849
189TET1_21451524_ChIP-Seq_MESCs_Mouse0.44159359
190ERG_20517297_ChIP-Seq_VCAP_Human0.43974974
191E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.43956529
192SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.43736564

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.10079134
2MP0005360_urolithiasis7.19360637
3MP0005365_abnormal_bile_salt6.07840713
4MP0005085_abnormal_gallbladder_physiolo6.03664541
5MP0008875_abnormal_xenobiotic_pharmacok5.03286767
6MP0003806_abnormal_nucleotide_metabolis3.88565261
7MP0003252_abnormal_bile_duct3.80094292
8MP0010329_abnormal_lipoprotein_level3.50902002
9MP0009840_abnormal_foam_cell3.20002660
10MP0005332_abnormal_amino_acid2.83728277
11MP0005083_abnormal_biliary_tract2.74355901
12MP0003136_yellow_coat_color2.71023817
13MP0002102_abnormal_ear_morphology2.55956558
14MP0003195_calcinosis2.53843559
15MP0001666_abnormal_nutrient_absorption2.53505810
16MP0004019_abnormal_vitamin_homeostasis2.32283566
17MP0003011_delayed_dark_adaptation2.30370039
18MP0003191_abnormal_cellular_cholesterol2.28016766
19MP0003878_abnormal_ear_physiology2.25068223
20MP0005377_hearing/vestibular/ear_phenot2.25068223
21MP0005551_abnormal_eye_electrophysiolog2.22144327
22MP0000609_abnormal_liver_physiology2.21742711
23MP0002118_abnormal_lipid_homeostasis2.16692210
24MP0003880_abnormal_central_pattern2.04218339
25MP0002638_abnormal_pupillary_reflex2.02348436
26MP0005319_abnormal_enzyme/_coenzyme1.97685118
27MP0005646_abnormal_pituitary_gland1.95369675
28MP0001984_abnormal_olfaction1.94421243
29MP0009780_abnormal_chondrocyte_physiolo1.94051569
30MP0002736_abnormal_nociception_after1.92925001
31MP0002938_white_spotting1.91895611
32MP0002254_reproductive_system_inflammat1.79454393
33MP0003868_abnormal_feces_composition1.77996623
34MP0001968_abnormal_touch/_nociception1.74302603
35MP0006276_abnormal_autonomic_nervous1.73443953
36MP0002138_abnormal_hepatobiliary_system1.73320583
37MP0005451_abnormal_body_composition1.62726263
38MP0000372_irregular_coat_pigmentation1.61606378
39MP0005645_abnormal_hypothalamus_physiol1.57649685
40MP0005584_abnormal_enzyme/coenzyme_acti1.57117959
41MP0005253_abnormal_eye_physiology1.51298909
42MP0005670_abnormal_white_adipose1.49183187
43MP0001764_abnormal_homeostasis1.45965392
44MP0004142_abnormal_muscle_tone1.45598823
45MP0000427_abnormal_hair_cycle1.45213103
46MP0001529_abnormal_vocalization1.44482148
47MP0003705_abnormal_hypodermis_morpholog1.44114060
48MP0003186_abnormal_redox_activity1.43076108
49MP0009643_abnormal_urine_homeostasis1.39259616
50MP0008995_early_reproductive_senescence1.37944957
51MP0003646_muscle_fatigue1.37110226
52MP0006072_abnormal_retinal_apoptosis1.34798391
53MP0002234_abnormal_pharynx_morphology1.28947880
54MP0002653_abnormal_ependyma_morphology1.25403596
55MP0001485_abnormal_pinna_reflex1.25344353
56MP0006292_abnormal_olfactory_placode1.22765978
57MP0006036_abnormal_mitochondrial_physio1.20363089
58MP0004147_increased_porphyrin_level1.20272238
59MP0004885_abnormal_endolymph1.16774411
60MP0002909_abnormal_adrenal_gland1.16667499
61MP0001486_abnormal_startle_reflex1.16054714
62MP0000631_abnormal_neuroendocrine_gland1.15810488
63MP0001501_abnormal_sleep_pattern1.14537895
64* MP0000598_abnormal_liver_morphology1.13134603
65MP0000647_abnormal_sebaceous_gland1.13051163
66MP0000566_synostosis1.10606953
67MP0006035_abnormal_mitochondrial_morpho1.09483047
68MP0008789_abnormal_olfactory_epithelium1.09447760
69MP0005647_abnormal_sex_gland1.09250840
70MP0002822_catalepsy1.09021623
71MP0009745_abnormal_behavioral_response1.08061180
72MP0009697_abnormal_copulation1.07519555
73MP0002277_abnormal_respiratory_mucosa1.04721378
74MP0004264_abnormal_extraembryonic_tissu1.04116298
75MP0005379_endocrine/exocrine_gland_phen1.03645846
76MP0001986_abnormal_taste_sensitivity1.03098476
77MP0004133_heterotaxia1.01310742
78MP0003122_maternal_imprinting1.01129966
79MP0004130_abnormal_muscle_cell1.00764488
80MP0005174_abnormal_tail_pigmentation0.98372881
81MP0003656_abnormal_erythrocyte_physiolo0.97615248
82MP0001502_abnormal_circadian_rhythm0.97470361
83MP0002971_abnormal_brown_adipose0.96343869
84MP0002095_abnormal_skin_pigmentation0.96020680
85MP0000026_abnormal_inner_ear0.94652570
86MP0009046_muscle_twitch0.94002213
87MP0005636_abnormal_mineral_homeostasis0.93915259
88MP0002272_abnormal_nervous_system0.92436301
89MP0002557_abnormal_social/conspecific_i0.92012306
90MP0005666_abnormal_adipose_tissue0.91761675
91MP0005410_abnormal_fertilization0.91508048
92MP0002078_abnormal_glucose_homeostasis0.91265801
93MP0005266_abnormal_metabolism0.90471442
94MP0005423_abnormal_somatic_nervous0.90178047
95MP0002160_abnormal_reproductive_system0.89853543
96MP0004043_abnormal_pH_regulation0.89485097
97MP0009764_decreased_sensitivity_to0.87563947
98MP0009763_increased_sensitivity_to0.86997030
99MP0005386_behavior/neurological_phenoty0.85594625
100MP0004924_abnormal_behavior0.85594625
101MP0005376_homeostasis/metabolism_phenot0.85126303
102MP0008877_abnormal_DNA_methylation0.84541996
103MP0002876_abnormal_thyroid_physiology0.83923969
104MP0002572_abnormal_emotion/affect_behav0.82202975
105MP0005334_abnormal_fat_pad0.82019904
106MP0010386_abnormal_urinary_bladder0.81960015
107MP0000778_abnormal_nervous_system0.81890521
108MP0009642_abnormal_blood_homeostasis0.80819792
109MP0003879_abnormal_hair_cell0.80395558
110MP0010368_abnormal_lymphatic_system0.79499902
111MP0001944_abnormal_pancreas_morphology0.79434028
112MP0001324_abnormal_eye_pigmentation0.79355226
113MP0000538_abnormal_urinary_bladder0.79122772
114MP0005195_abnormal_posterior_eye0.79067669
115MP0000604_amyloidosis0.78866917
116MP0004145_abnormal_muscle_electrophysio0.77899687
117MP0001727_abnormal_embryo_implantation0.77190011
118MP0005389_reproductive_system_phenotype0.76948623
119MP0005535_abnormal_body_temperature0.76805998
120MP0000613_abnormal_salivary_gland0.75975810
121MP0008469_abnormal_protein_level0.73478493
122MP0001756_abnormal_urination0.72355454
123MP0001661_extended_life_span0.70402025
124MP0002332_abnormal_exercise_endurance0.70020714
125MP0009765_abnormal_xenobiotic_induced0.67889273
126MP0005084_abnormal_gallbladder_morpholo0.67626438
127MP0002970_abnormal_white_adipose0.66960318
128MP0004782_abnormal_surfactant_physiolog0.65692162
129MP0005448_abnormal_energy_balance0.65616346
130MP0008961_abnormal_basal_metabolism0.63030495
131MP0002837_dystrophic_cardiac_calcinosis0.60529229
132MP0009115_abnormal_fat_cell0.60241139
133MP0005248_abnormal_Harderian_gland0.58399292
134MP0002796_impaired_skin_barrier0.58339479
135MP0005220_abnormal_exocrine_pancreas0.57995758
136MP0004185_abnormal_adipocyte_glucose0.55928090
137MP0003690_abnormal_glial_cell0.55171973
138MP0005408_hypopigmentation0.54443563
139MP0002136_abnormal_kidney_physiology0.53691871
140MP0003718_maternal_effect0.53572575
141MP0005075_abnormal_melanosome_morpholog0.50937610
142MP0000639_abnormal_adrenal_gland0.50918547
143MP0003953_abnormal_hormone_level0.48870882
144MP0005395_other_phenotype0.46557671
145MP0003329_amyloid_beta_deposits0.45944120
146MP0001881_abnormal_mammary_gland0.45340868
147MP0010234_abnormal_vibrissa_follicle0.44280257
148MP0003890_abnormal_embryonic-extraembry0.42295965
149MP0008872_abnormal_physiological_respon0.42100831
150MP0000230_abnormal_systemic_arterial0.41738016
151MP0009672_abnormal_birth_weight0.41459394
152MP0002269_muscular_atrophy0.41018500
153MP0002928_abnormal_bile_duct0.39694145
154MP0008874_decreased_physiological_sensi0.36679682
155MP0008873_increased_physiological_sensi0.36403261
156MP0006082_CNS_inflammation0.36009868
157MP0005375_adipose_tissue_phenotype0.34940975
158MP0001765_abnormal_ion_homeostasis0.34114867
159MP0004381_abnormal_hair_follicle0.33298653
160MP0005452_abnormal_adipose_tissue0.33028801
161MP0003638_abnormal_response/metabolism_0.32609547
162MP0005330_cardiomyopathy0.31816929
163MP0003075_altered_response_to0.27584383
164MP0002168_other_aberrant_phenotype0.25810204
165MP0001243_abnormal_dermal_layer0.25154754
166MP0002090_abnormal_vision0.25122940
167MP0000249_abnormal_blood_vessel0.24848694
168MP0002127_abnormal_cardiovascular_syste0.24368007

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.86717587
2Intrahepatic cholestasis (HP:0001406)6.52750151
3Deep venous thrombosis (HP:0002625)6.44044543
4Xanthomatosis (HP:0000991)6.00818872
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.98606689
6Hypobetalipoproteinemia (HP:0003563)5.74954469
7Prolonged partial thromboplastin time (HP:0003645)5.44792252
8Hyperlipoproteinemia (HP:0010980)5.34417853
9Hyperglycinuria (HP:0003108)5.01885527
10Hyperammonemia (HP:0001987)4.92873604
11Hyperglycinemia (HP:0002154)4.79130653
12Ketosis (HP:0001946)4.68183155
13Abnormality of glycine metabolism (HP:0010895)4.68160035
14Abnormality of serine family amino acid metabolism (HP:0010894)4.68160035
15Hypolipoproteinemia (HP:0010981)4.50479454
16Complement deficiency (HP:0004431)4.46066702
17Epidermoid cyst (HP:0200040)4.26970708
18Hypoglycemic coma (HP:0001325)4.19915418
19Hypoalphalipoproteinemia (HP:0003233)4.16661416
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.14820507
21True hermaphroditism (HP:0010459)4.13130910
22Abnormality of glutamine family amino acid metabolism (HP:0010902)4.03181357
23Abnormality of sulfur amino acid metabolism (HP:0004339)4.02561543
24Abnormality of aspartate family amino acid metabolism (HP:0010899)4.00835296
25Abnormality of the intrinsic pathway (HP:0010989)3.98379419
26Joint hemorrhage (HP:0005261)3.97279626
27Abnormality of methionine metabolism (HP:0010901)3.88031018
28Pancreatic fibrosis (HP:0100732)3.86401328
29Ketoacidosis (HP:0001993)3.77297289
30Abnormality of fatty-acid metabolism (HP:0004359)3.73428074
31Pancreatic cysts (HP:0001737)3.73189572
32Hypochromic microcytic anemia (HP:0004840)3.65634588
33Fat malabsorption (HP:0002630)3.64399371
34Abnormality of the common coagulation pathway (HP:0010990)3.64149939
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.51425508
36Hypercholesterolemia (HP:0003124)3.51259875
37Abnormality of midbrain morphology (HP:0002418)3.46785375
38Molar tooth sign on MRI (HP:0002419)3.46785375
39Abnormality of pyrimidine metabolism (HP:0004353)3.39589800
40Gout (HP:0001997)3.32341026
41Skin nodule (HP:0200036)3.25311987
42Abnormality of serum amino acid levels (HP:0003112)3.21021454
43Abnormality of nucleobase metabolism (HP:0010932)3.20783922
44Abnormality of complement system (HP:0005339)3.18498351
45Conjugated hyperbilirubinemia (HP:0002908)3.14264184
46Abnormality of dicarboxylic acid metabolism (HP:0010995)3.14203031
47Dicarboxylic aciduria (HP:0003215)3.14203031
48Abnormality of purine metabolism (HP:0004352)3.11380983
49Metabolic acidosis (HP:0001942)3.10716298
50Medial flaring of the eyebrow (HP:0010747)3.10634149
51Hyperinsulinemic hypoglycemia (HP:0000825)3.03531596
52Hyperbilirubinemia (HP:0002904)3.02144433
53Delayed CNS myelination (HP:0002188)3.00477880
54Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.93119954
55Abnormality of alanine metabolism (HP:0010916)2.93119954
56Hyperalaninemia (HP:0003348)2.93119954
57Acute necrotizing encephalopathy (HP:0006965)2.92648259
58Large for gestational age (HP:0001520)2.92517269
59Congenital stationary night blindness (HP:0007642)2.90305297
60Malnutrition (HP:0004395)2.88706400
61Lethargy (HP:0001254)2.87558031
62Nephronophthisis (HP:0000090)2.87000680
63Acute encephalopathy (HP:0006846)2.84652991
64Mitochondrial inheritance (HP:0001427)2.81751461
65Type II lissencephaly (HP:0007260)2.81665106
66Abnormality of the renal cortex (HP:0011035)2.73296148
67Abnormal mitochondria in muscle tissue (HP:0008316)2.70998668
68Increased CSF lactate (HP:0002490)2.69299843
69Steatorrhea (HP:0002570)2.69043745
70Hyperventilation (HP:0002883)2.67332442
71Hepatic necrosis (HP:0002605)2.66160174
72Abnormal cartilage morphology (HP:0002763)2.65616748
73Congenital primary aphakia (HP:0007707)2.64076411
74Gait imbalance (HP:0002141)2.63206301
75Renal cortical cysts (HP:0000803)2.61064242
76Progressive macrocephaly (HP:0004481)2.60698970
77Hypoglycemic seizures (HP:0002173)2.60402960
78Myocardial infarction (HP:0001658)2.59912546
79Hepatocellular carcinoma (HP:0001402)2.58809333
80Irritability (HP:0000737)2.56546076
81Cystic liver disease (HP:0006706)2.55160901
82Generalized aminoaciduria (HP:0002909)2.54296308
83Lipid accumulation in hepatocytes (HP:0006561)2.50680249
84Nephrogenic diabetes insipidus (HP:0009806)2.50594663
85Abnormality of the renal medulla (HP:0100957)2.46205751
86Sclerocornea (HP:0000647)2.45198941
87Chronic hepatic failure (HP:0100626)2.43936355
88Vascular calcification (HP:0004934)2.42474463
89Spontaneous abortion (HP:0005268)2.41730415
90Vomiting (HP:0002013)2.41627664
91Aplasia/Hypoplasia of the tongue (HP:0010295)2.38940393
92Aplasia/Hypoplasia of the tibia (HP:0005772)2.36302958
93Abnormal gallbladder morphology (HP:0012437)2.33705089
94Anencephaly (HP:0002323)2.33635315
95Hyperuricemia (HP:0002149)2.33013732
96Increased purine levels (HP:0004368)2.33013732
97Cholecystitis (HP:0001082)2.32956025
98Abnormal gallbladder physiology (HP:0012438)2.32956025
99Spastic diplegia (HP:0001264)2.31911388
100Cholelithiasis (HP:0001081)2.31136102
101Proximal tubulopathy (HP:0000114)2.31094335
102Hepatocellular necrosis (HP:0001404)2.30025013
103Cerebral edema (HP:0002181)2.28603631
104Increased hepatocellular lipid droplets (HP:0006565)2.28362710
105Short tibia (HP:0005736)2.26743777
1063-Methylglutaconic aciduria (HP:0003535)2.24840986
107Postaxial foot polydactyly (HP:0001830)2.24511819
108Abolished electroretinogram (ERG) (HP:0000550)2.23621329
109Late onset (HP:0003584)2.22484832
110Brushfield spots (HP:0001088)2.22018923
111Renal Fanconi syndrome (HP:0001994)2.21321492
112Genital tract atresia (HP:0001827)2.20576396
113Enlarged kidneys (HP:0000105)2.16755881
114Decreased electroretinogram (ERG) amplitude (HP:0000654)2.15237318
115Pancreatitis (HP:0001733)2.14711544
116Lactic acidosis (HP:0003128)2.11629364
117Neonatal onset (HP:0003623)2.11385889
118Male pseudohermaphroditism (HP:0000037)2.10947222
119Vaginal atresia (HP:0000148)2.10916481
120Cardiovascular calcification (HP:0011915)2.09763820
121Occipital encephalocele (HP:0002085)2.08367821
122Abnormality of proline metabolism (HP:0010907)2.08093405
123Hydroxyprolinuria (HP:0003080)2.08093405
124Amyloidosis (HP:0011034)2.07856390
125Tubulointerstitial nephritis (HP:0001970)2.07623229
126Abnormal respiratory epithelium morphology (HP:0012253)2.07593625
127Abnormal respiratory motile cilium morphology (HP:0005938)2.07593625
128Systemic lupus erythematosus (HP:0002725)2.07423199
129Rickets (HP:0002748)2.06519943
130Sensorimotor neuropathy (HP:0007141)2.06268751
131Abnormal rod and cone electroretinograms (HP:0008323)2.06203327
132Hyperglycemia (HP:0003074)2.03297594
133Ragged-red muscle fibers (HP:0003200)2.02768530
134Severe muscular hypotonia (HP:0006829)2.02035794
135Acanthocytosis (HP:0001927)2.01450137
136Tubular atrophy (HP:0000092)1.99572335
137Multiple enchondromatosis (HP:0005701)1.99402535
138Methylmalonic aciduria (HP:0012120)1.97500859
139Postaxial hand polydactyly (HP:0001162)1.96386761
140Increased serum lactate (HP:0002151)1.96246471
141Methylmalonic acidemia (HP:0002912)1.96062242
142Status epilepticus (HP:0002133)1.95766853
143Myoglobinuria (HP:0002913)1.94923590
144Lissencephaly (HP:0001339)1.94623279
145Furrowed tongue (HP:0000221)1.93711619
146Abnormal drinking behavior (HP:0030082)1.92572935
147Polydipsia (HP:0001959)1.92572935
148Pachygyria (HP:0001302)1.90831285
149Concave nail (HP:0001598)1.90659498
150Abnormal enzyme/coenzyme activity (HP:0012379)1.89739733
151Abnormality of vitamin metabolism (HP:0100508)1.89681736
152Hepatoblastoma (HP:0002884)1.89540094
153Congenital hepatic fibrosis (HP:0002612)1.89412575
154Nausea (HP:0002018)1.88445385
155Abnormality of macular pigmentation (HP:0008002)1.88418720
156Hyperphosphaturia (HP:0003109)1.88232783
157Esophageal varix (HP:0002040)1.87771696
158Attenuation of retinal blood vessels (HP:0007843)1.86066084
159Preaxial hand polydactyly (HP:0001177)1.85742079
160Polyphagia (HP:0002591)1.85606333
161Increased muscle lipid content (HP:0009058)1.85585353
162Optic nerve hypoplasia (HP:0000609)1.83856981
163Abnormality of the gallbladder (HP:0005264)1.83212852
164Bile duct proliferation (HP:0001408)1.83044979
165Abnormal biliary tract physiology (HP:0012439)1.83044979
166Abnormality of transition element cation homeostasis (HP:0011030)1.83017511
167Glycosuria (HP:0003076)1.82766006
168Abnormality of urine glucose concentration (HP:0011016)1.82766006
169Pendular nystagmus (HP:0012043)1.82104382
170Abnormality of iron homeostasis (HP:0011031)1.81970348
171Respiratory failure (HP:0002878)1.81090795
172Hypertriglyceridemia (HP:0002155)1.81047571
173Abnormality of the lower motor neuron (HP:0002366)1.81026819
174Adrenal hypoplasia (HP:0000835)1.80531453
175Increased serum pyruvate (HP:0003542)1.80224400
176Inability to walk (HP:0002540)1.78881281
177Abnormal ciliary motility (HP:0012262)1.78191911
178Retinitis pigmentosa (HP:0000510)1.77816358
179Cerebellar dysplasia (HP:0007033)1.77530446
180Poor coordination (HP:0002370)1.74912154

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.42433759
2ERN15.78779688
3SIK13.83071016
4CDK123.00737219
5FGFR42.90079891
6INSRR2.80160020
7STK162.77942642
8NUAK12.72061161
9GRK62.42061241
10CASK2.35926985
11BCR2.32528293
12MAP4K22.32506941
13MAP2K42.27017174
14TRIM282.25106123
15STK392.18906890
16TAOK32.16598118
17TRIB32.12728186
18GRK52.08339367
19ERBB42.02300321
20LATS11.91677226
21GRK11.85807307
22PKN21.69904101
23NME11.67557091
24TGFBR21.61337303
25STK38L1.54685581
26MAP3K41.49717672
27MAPK71.48326819
28BMPR1B1.43326957
29MST1R1.42674940
30EIF2AK31.42045990
31PDK41.41720008
32PDK31.41720008
33ZAK1.41660819
34CSF1R1.40516696
35PAK31.40021727
36ERBB31.39409816
37FLT31.38262776
38MST41.38097249
39MAPK111.36536809
40MAPK131.34546892
41MAP3K71.32645620
42MUSK1.28346004
43PIK3CG1.27935670
44NTRK21.26922348
45PRKAA21.26868250
46PINK11.24516086
47PHKG21.23929356
48PHKG11.23929356
49ABL21.21876947
50PIK3CA1.18192399
51PRKCG1.16810578
52FRK1.15541758
53PRKCE1.15464939
54CSNK1G21.11850760
55DYRK1B1.11507760
56OXSR11.09914163
57TTK1.08696328
58TLK11.08252444
59PRKCI1.06141678
60ADRBK21.04509165
61MARK11.03470930
62MAP2K71.03005783
63MAPK121.02644283
64MAP2K61.02066926
65CAMK1D1.01153349
66CSNK1G11.01138228
67FGFR31.00855637
68EPHB20.99027981
69MOS0.95358630
70CSNK1G30.95329805
71LATS20.94038939
72OBSCN0.93887678
73MAP3K30.91515603
74NTRK30.89563186
75TXK0.89549947
76PRKAA10.89354381
77ACVR1B0.88801556
78JAK20.86718114
79TYRO30.85624130
80MAP2K30.83396174
81MAPKAPK30.82738668
82TAOK20.82295399
83EPHA40.80361729
84DYRK20.78635525
85RIPK10.76683467
86CAMK10.76507481
87MAPK40.76158146
88PDK20.76017966
89CSNK1A1L0.75919793
90CAMK40.75292675
91FER0.74797720
92FGFR20.74669929
93PTK60.73295560
94TYK20.72433962
95CAMK2D0.72364184
96ERBB20.71740174
97MAP3K100.70486229
98PRKG20.69191828
99GRK70.69124907
100CSK0.67848451
101PRKACG0.67553586
102MET0.62758385
103PRKACA0.62360731
104DYRK30.62097427
105MAPK150.61974671
106MATK0.61698578
107PLK20.61537855
108STK100.61300864
109PTK20.60279486
110BRSK20.58526135
111IRAK30.58030835
112EPHA30.57649968
113MTOR0.57470938
114DAPK20.57403780
115GSK3A0.56930635
116TNIK0.55870213
117AKT30.55578204
118WNK30.54367754
119CAMK2A0.54282886
120IGF1R0.54148317
121SGK30.54011855
122EIF2AK10.52632368
123PKN10.52265428
124NEK90.51562017
125MAP3K120.51120854
126KDR0.51114924
127STK380.50945308
128CSNK1A10.50842423
129PRKCZ0.50729630
130PLK40.49789418
131PNCK0.47937606
132MAP3K60.47295477
133CDK40.46421959
134SIK30.46322514
135NEK10.46309109
136AKT20.46267971
137STK30.45841253
138STK240.45372166
139EIF2AK20.44848719
140LIMK10.44206336
141PLK10.43884602
142MAP3K50.43095905
143DMPK0.42505071
144MARK20.42405421
145PDPK10.41736913
146WNK40.41361002
147SGK20.40406474
148PRKCA0.38994663
149TIE10.37997959
150CDK60.37600022
151PDK10.37455063
152PRKACB0.36126635
153ICK0.35298287
154EPHA20.35006128
155CAMK2G0.34523407
156NEK60.34405134
157VRK10.32974016
158ADRBK10.32717641
159MAP2K10.32440162
160MAP3K110.31825433
161NTRK10.31422540
162CSNK1D0.30684393
163PRKG10.30663651
164JAK10.30106829
165CSNK1E0.29823873
166PLK30.29344902
167TAOK10.28143468
168PDGFRA0.27714887
169KSR20.27603396
170SGK2230.25966668
171SGK4940.25966668
172WNK10.24052939

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.02707203
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.22131248
3Nitrogen metabolism_Homo sapiens_hsa009103.10997427
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.92812543
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.78726718
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.78198301
7Fatty acid degradation_Homo sapiens_hsa000712.76238050
8Tryptophan metabolism_Homo sapiens_hsa003802.74965961
9Arginine biosynthesis_Homo sapiens_hsa002202.70249037
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.66135350
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.40506729
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.39713796
13Complement and coagulation cascades_Homo sapiens_hsa046102.32630844
14Butanoate metabolism_Homo sapiens_hsa006502.28971415
15Propanoate metabolism_Homo sapiens_hsa006402.28737358
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.22534314
17Oxidative phosphorylation_Homo sapiens_hsa001902.14252498
18PPAR signaling pathway_Homo sapiens_hsa033202.13586556
19Fatty acid metabolism_Homo sapiens_hsa012122.11941552
20* Peroxisome_Homo sapiens_hsa041462.10394161
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.01588463
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.98975097
23Chemical carcinogenesis_Homo sapiens_hsa052041.89716030
24beta-Alanine metabolism_Homo sapiens_hsa004101.81206180
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.78254069
26Protein export_Homo sapiens_hsa030601.76165822
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.74962684
28Histidine metabolism_Homo sapiens_hsa003401.74157920
29Caffeine metabolism_Homo sapiens_hsa002321.72045720
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.69747148
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66381098
32Parkinsons disease_Homo sapiens_hsa050121.65913948
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.65230649
34Retinol metabolism_Homo sapiens_hsa008301.63800453
35Pyruvate metabolism_Homo sapiens_hsa006201.59123416
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.58441781
37Vitamin B6 metabolism_Homo sapiens_hsa007501.56018542
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44547301
39Bile secretion_Homo sapiens_hsa049761.43605832
40Fatty acid elongation_Homo sapiens_hsa000621.43296820
41Phenylalanine metabolism_Homo sapiens_hsa003601.42788681
42Selenocompound metabolism_Homo sapiens_hsa004501.42423306
43Folate biosynthesis_Homo sapiens_hsa007901.34202478
44Carbon metabolism_Homo sapiens_hsa012001.34014314
45Staphylococcus aureus infection_Homo sapiens_hsa051501.32274036
46Starch and sucrose metabolism_Homo sapiens_hsa005001.30696169
47Tyrosine metabolism_Homo sapiens_hsa003501.30215190
48Cysteine and methionine metabolism_Homo sapiens_hsa002701.29219006
49Fat digestion and absorption_Homo sapiens_hsa049751.28105915
50Biosynthesis of amino acids_Homo sapiens_hsa012301.23378456
51Sulfur metabolism_Homo sapiens_hsa009201.22928156
52Huntingtons disease_Homo sapiens_hsa050161.22430284
53RNA polymerase_Homo sapiens_hsa030201.10619850
54ABC transporters_Homo sapiens_hsa020101.08846999
55Maturity onset diabetes of the young_Homo sapiens_hsa049501.06662294
56Alzheimers disease_Homo sapiens_hsa050101.04143863
57Cardiac muscle contraction_Homo sapiens_hsa042601.02631695
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97717614
59Proteasome_Homo sapiens_hsa030500.96919878
60Sulfur relay system_Homo sapiens_hsa041220.96225505
61Arginine and proline metabolism_Homo sapiens_hsa003300.95779602
62Glycerolipid metabolism_Homo sapiens_hsa005610.95042807
63Vitamin digestion and absorption_Homo sapiens_hsa049770.94754755
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92525849
65Cyanoamino acid metabolism_Homo sapiens_hsa004600.92159985
66Steroid biosynthesis_Homo sapiens_hsa001000.91812901
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90703770
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89175944
69Lysine degradation_Homo sapiens_hsa003100.87773025
70Phototransduction_Homo sapiens_hsa047440.84935857
71Fatty acid biosynthesis_Homo sapiens_hsa000610.83184252
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81721678
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80436929
74Fanconi anemia pathway_Homo sapiens_hsa034600.78621708
75Homologous recombination_Homo sapiens_hsa034400.78419403
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76911279
77Nicotine addiction_Homo sapiens_hsa050330.74890343
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73895674
79Basal transcription factors_Homo sapiens_hsa030220.73050893
80Fructose and mannose metabolism_Homo sapiens_hsa000510.72394367
81Glutathione metabolism_Homo sapiens_hsa004800.70570112
82Pentose phosphate pathway_Homo sapiens_hsa000300.68601825
83One carbon pool by folate_Homo sapiens_hsa006700.67074103
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63021884
85Collecting duct acid secretion_Homo sapiens_hsa049660.59521058
86Mineral absorption_Homo sapiens_hsa049780.59016968
87Ribosome_Homo sapiens_hsa030100.56522957
88Galactose metabolism_Homo sapiens_hsa000520.56425483
89Linoleic acid metabolism_Homo sapiens_hsa005910.54083448
90Insulin secretion_Homo sapiens_hsa049110.53716392
91Metabolic pathways_Homo sapiens_hsa011000.52469288
92Purine metabolism_Homo sapiens_hsa002300.44874023
93RNA degradation_Homo sapiens_hsa030180.40579965
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38153634
95Pancreatic secretion_Homo sapiens_hsa049720.37620135
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.36114986
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35654045
98Pyrimidine metabolism_Homo sapiens_hsa002400.34720643
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.34500159
100Insulin resistance_Homo sapiens_hsa049310.33024932
101AMPK signaling pathway_Homo sapiens_hsa041520.19434883
102Arachidonic acid metabolism_Homo sapiens_hsa005900.18422203
103Prion diseases_Homo sapiens_hsa050200.14701885
104Glucagon signaling pathway_Homo sapiens_hsa049220.13893158
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.10374512
106Ovarian steroidogenesis_Homo sapiens_hsa049130.09960961
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.09693281
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.01176245
109Hepatitis C_Homo sapiens_hsa05160-0.2080259
110Bladder cancer_Homo sapiens_hsa05219-0.1945178
111Other glycan degradation_Homo sapiens_hsa00511-0.1923636
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1672464
113Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1638634
114Circadian rhythm_Homo sapiens_hsa04710-0.1614778
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603-0.1374650
116Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1257171
117Protein digestion and absorption_Homo sapiens_hsa04974-0.1182997
118Ether lipid metabolism_Homo sapiens_hsa00565-0.1166692
119Renin-angiotensin system_Homo sapiens_hsa04614-0.1164799
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1086659
121Insulin signaling pathway_Homo sapiens_hsa04910-0.0503230
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0488024
123Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0455870
124Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0153910
125Regulation of autophagy_Homo sapiens_hsa04140-0.0010277

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