PEX11G

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the PEX11 family. This family is reported to regulate the number and size of peroxisomes in evolutionarily distant organisms. The protein encoded by this gene may induce clustering of peroxisomes. Alternative splicing results in multiple transcript variants that encode different protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.48759733
2L-phenylalanine catabolic process (GO:0006559)7.48759733
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.11504475
4L-phenylalanine metabolic process (GO:0006558)7.11504475
5aromatic amino acid family catabolic process (GO:0009074)6.73925701
6indole-containing compound catabolic process (GO:0042436)6.18917132
7indolalkylamine catabolic process (GO:0046218)6.18917132
8tryptophan catabolic process (GO:0006569)6.18917132
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.92621513
10kynurenine metabolic process (GO:0070189)5.90256420
11tryptophan metabolic process (GO:0006568)5.88092461
12bile acid biosynthetic process (GO:0006699)5.64276003
13positive regulation of mast cell degranulation (GO:0043306)5.62310530
14positive regulation of mast cell activation involved in immune response (GO:0033008)5.62310530
15glyoxylate metabolic process (GO:0046487)5.55253142
16urea cycle (GO:0000050)5.42503856
17urea metabolic process (GO:0019627)5.42503856
18alpha-linolenic acid metabolic process (GO:0036109)5.33171619
19high-density lipoprotein particle remodeling (GO:0034375)5.33062117
20cysteine metabolic process (GO:0006534)5.28613674
21sulfur amino acid catabolic process (GO:0000098)5.28475543
22negative regulation of fibrinolysis (GO:0051918)5.13708878
23fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.05848069
24peptidyl-glutamic acid carboxylation (GO:0017187)5.01881120
25protein carboxylation (GO:0018214)5.01881120
26nitrogen cycle metabolic process (GO:0071941)4.97757008
27serine family amino acid catabolic process (GO:0009071)4.96172651
28regulation of fibrinolysis (GO:0051917)4.96034106
29complement activation, alternative pathway (GO:0006957)4.90733033
30aromatic amino acid family metabolic process (GO:0009072)4.87995452
31regulation of protein activation cascade (GO:2000257)4.84469502
32bile acid metabolic process (GO:0008206)4.83819326
33axonemal dynein complex assembly (GO:0070286)4.82598809
34regulation of triglyceride catabolic process (GO:0010896)4.72458416
35reverse cholesterol transport (GO:0043691)4.67967102
36homocysteine metabolic process (GO:0050667)4.67674115
37tyrosine metabolic process (GO:0006570)4.65232063
38alpha-amino acid catabolic process (GO:1901606)4.64768320
39regulation of cholesterol esterification (GO:0010872)4.62909964
40amino-acid betaine metabolic process (GO:0006577)4.58009213
41protein-lipid complex remodeling (GO:0034368)4.56227227
42macromolecular complex remodeling (GO:0034367)4.56227227
43plasma lipoprotein particle remodeling (GO:0034369)4.56227227
44lysine catabolic process (GO:0006554)4.52605976
45lysine metabolic process (GO:0006553)4.52605976
46regulation of tolerance induction (GO:0002643)4.51863948
47regulation of complement activation (GO:0030449)4.51379325
48indolalkylamine metabolic process (GO:0006586)4.44413573
49coenzyme catabolic process (GO:0009109)4.43340077
50triglyceride homeostasis (GO:0070328)4.41538741
51acylglycerol homeostasis (GO:0055090)4.41538741
52phospholipid efflux (GO:0033700)4.39564944
53cellular biogenic amine catabolic process (GO:0042402)4.39066045
54amine catabolic process (GO:0009310)4.39066045
55positive regulation of mast cell activation (GO:0033005)4.38851664
56T cell apoptotic process (GO:0070231)4.38695991
57negative regulation of sterol transport (GO:0032372)4.34150362
58negative regulation of cholesterol transport (GO:0032375)4.34150362
59glycine metabolic process (GO:0006544)4.33204800
60cellular amino acid catabolic process (GO:0009063)4.29443631
61bile acid and bile salt transport (GO:0015721)4.24136420
62cellular modified amino acid catabolic process (GO:0042219)4.21561309
63imidazole-containing compound metabolic process (GO:0052803)4.21132470
64lipoxygenase pathway (GO:0019372)4.20997191
65regulation of T cell tolerance induction (GO:0002664)4.20355236
66serine family amino acid metabolic process (GO:0009069)4.14499381
67cellular biogenic amine biosynthetic process (GO:0042401)4.13112117
68serine family amino acid biosynthetic process (GO:0009070)4.12953081
69positive regulation of myeloid leukocyte mediated immunity (GO:0002888)4.09329237
70benzene-containing compound metabolic process (GO:0042537)4.08649150
71ethanol oxidation (GO:0006069)4.07506995
72amine biosynthetic process (GO:0009309)4.02391777
73regulation of mast cell activation involved in immune response (GO:0033006)4.00451207
74cilium or flagellum-dependent cell motility (GO:0001539)4.00277043
75cellular ketone body metabolic process (GO:0046950)3.98916876
76cellular glucuronidation (GO:0052695)3.98504007
77glutamate metabolic process (GO:0006536)3.97625106
78plasma lipoprotein particle clearance (GO:0034381)3.96339891
79cholesterol efflux (GO:0033344)3.92402962
80low-density lipoprotein particle remodeling (GO:0034374)3.90574680
81positive regulation of leukocyte degranulation (GO:0043302)3.89834712
82arginine metabolic process (GO:0006525)3.86678532
83aldehyde catabolic process (GO:0046185)3.84113348
84motile cilium assembly (GO:0044458)3.81587471
85lymphocyte apoptotic process (GO:0070227)3.80166482
86angiotensin maturation (GO:0002003)3.80040515
87regulation of mast cell degranulation (GO:0043304)3.80012982
88intestinal cholesterol absorption (GO:0030299)3.78910679
89carboxylic acid catabolic process (GO:0046395)3.78850138
90organic acid catabolic process (GO:0016054)3.78850138
91plasma lipoprotein particle assembly (GO:0034377)3.76860294
92drug catabolic process (GO:0042737)3.75633205
93dicarboxylic acid biosynthetic process (GO:0043650)3.75125602
94cofactor catabolic process (GO:0051187)3.74634981
95positive regulation of triglyceride lipase activity (GO:0061365)3.68679039
96positive regulation of lipoprotein lipase activity (GO:0051006)3.68679039
97carnitine metabolic process (GO:0009437)3.68049797
98valine metabolic process (GO:0006573)3.66783082
99very-low-density lipoprotein particle assembly (GO:0034379)3.63538843
100NAD biosynthetic process (GO:0009435)3.62974375
101purine deoxyribonucleotide catabolic process (GO:0009155)3.61662263
102cellular response to exogenous dsRNA (GO:0071360)3.59340373
103response to nitrosative stress (GO:0051409)3.57520923
104blood coagulation, intrinsic pathway (GO:0007597)3.57374883
105negative regulation of lipase activity (GO:0060192)3.57331047
106short-chain fatty acid metabolic process (GO:0046459)3.57034021
107cholesterol homeostasis (GO:0042632)3.56956594
108phospholipid homeostasis (GO:0055091)3.56358418
109cytolysis (GO:0019835)3.55016075
110fibrinolysis (GO:0042730)3.53746378
111complement activation, classical pathway (GO:0006958)3.53014318
112aspartate family amino acid catabolic process (GO:0009068)3.52517353
113pyridine nucleotide biosynthetic process (GO:0019363)3.51385278
114nicotinamide nucleotide biosynthetic process (GO:0019359)3.51385278
115regulation of bile acid biosynthetic process (GO:0070857)3.51235661
116plasma lipoprotein particle organization (GO:0071827)3.51059508
117sterol homeostasis (GO:0055092)3.50421034
118glucuronate metabolic process (GO:0019585)3.49157570
119uronic acid metabolic process (GO:0006063)3.49157570
120amyloid precursor protein catabolic process (GO:0042987)3.48835117
121fatty acid beta-oxidation (GO:0006635)3.48420573
122GDP-mannose metabolic process (GO:0019673)3.47655744
123acetyl-CoA metabolic process (GO:0006084)3.47215765
124cilium movement (GO:0003341)3.45226553
125leukocyte apoptotic process (GO:0071887)3.45027947
126pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.38015685
127oligosaccharide catabolic process (GO:0009313)3.32259890
128biotin metabolic process (GO:0006768)3.23494238
129regulation of T cell cytokine production (GO:0002724)3.15953199
130deoxyribonucleotide catabolic process (GO:0009264)3.15380687
131protein insertion into membrane (GO:0051205)3.14302967
132pentose metabolic process (GO:0019321)3.11878121
133regulation of mast cell activation (GO:0033003)3.11607691
134amino sugar catabolic process (GO:0046348)3.11565324
135iron-sulfur cluster assembly (GO:0016226)3.07063922
136metallo-sulfur cluster assembly (GO:0031163)3.07063922
137ethanol metabolic process (GO:0006067)3.06225331
138regulation of helicase activity (GO:0051095)3.01651146
139base-excision repair, AP site formation (GO:0006285)2.97552261
140determination of adult lifespan (GO:0008340)2.96028890
141positive regulation of protein sumoylation (GO:0033235)2.95231699
142muscle cell fate commitment (GO:0042693)2.93921844
143urate metabolic process (GO:0046415)2.89498933
144deoxyribose phosphate catabolic process (GO:0046386)2.84290197
145peptidyl-histidine modification (GO:0018202)2.81211170
146somatic hypermutation of immunoglobulin genes (GO:0016446)2.81072222
147somatic diversification of immune receptors via somatic mutation (GO:0002566)2.81072222
148quinone biosynthetic process (GO:1901663)2.79591005
149phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.78748043
150UV protection (GO:0009650)2.77869992
151regulation of chemokine biosynthetic process (GO:0045073)2.77101455
152epithelial cilium movement (GO:0003351)2.76921899
153grooming behavior (GO:0007625)2.75656902
154peptidyl-arginine omega-N-methylation (GO:0035247)2.75366418
155snRNA metabolic process (GO:0016073)2.74711232
156positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.73246549
157immunoglobulin mediated immune response (GO:0016064)2.73015214
158ubiquinone biosynthetic process (GO:0006744)2.72984928
159snRNA processing (GO:0016180)2.71499351
160adenosine receptor signaling pathway (GO:0001973)2.71128979
161positive regulation of prostaglandin secretion (GO:0032308)2.69411415
162regulation of myeloid leukocyte mediated immunity (GO:0002886)2.68729465
163positive regulation of histone deacetylation (GO:0031065)2.67664796
164regulation of leukocyte degranulation (GO:0043300)2.59372093
165positive regulation of TOR signaling (GO:0032008)2.58087952
166response to xenobiotic stimulus (GO:0009410)2.56969094
167pyrimidine nucleotide catabolic process (GO:0006244)2.55221040
168sphingomyelin metabolic process (GO:0006684)2.54721637
169positive regulation of icosanoid secretion (GO:0032305)2.51935694
170mature B cell differentiation involved in immune response (GO:0002313)2.51919068
171positive regulation of regulated secretory pathway (GO:1903307)2.51873585
172negative regulation of glycoprotein metabolic process (GO:1903019)2.49312155
173NADP metabolic process (GO:0006739)2.48852453
174membrane protein intracellular domain proteolysis (GO:0031293)2.47894037
175deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.47385607
176organic cation transport (GO:0015695)2.47265319
177endothelial cell chemotaxis (GO:0035767)2.45237876
178ketone biosynthetic process (GO:0042181)2.44565043
179flavonoid metabolic process (GO:0009812)2.43723629
180fusion of sperm to egg plasma membrane (GO:0007342)2.42942969
181DNA damage response, signal transduction resulting in transcription (GO:0042772)2.42939159
182CDP-diacylglycerol metabolic process (GO:0046341)2.42672889
183polyamine biosynthetic process (GO:0006596)2.40138897
184glucosamine-containing compound catabolic process (GO:1901072)2.39789338
185exogenous drug catabolic process (GO:0042738)2.39705032
186DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.39566155
187sperm motility (GO:0030317)2.39269464

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.97446878
2EGR1_23403033_ChIP-Seq_LIVER_Mouse7.03448135
3PPARA_22158963_ChIP-Seq_LIVER_Mouse7.00664622
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.14429133
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.17829861
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.01846714
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.60177055
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.26422812
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.00800730
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.61249097
11VDR_21846776_ChIP-Seq_THP-1_Human2.82516651
12LXR_22292898_ChIP-Seq_THP-1_Human2.60099411
13ELF1_20517297_ChIP-Seq_JURKAT_Human2.39007485
14P68_20966046_ChIP-Seq_HELA_Human2.29633213
15GATA1_22025678_ChIP-Seq_K562_Human2.26151194
16ZNF263_19887448_ChIP-Seq_K562_Human2.24513054
17CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.23763240
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.13786185
19* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10712818
20BCL6_27268052_Chip-Seq_Bcells_Human2.07572696
21TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.02576122
22BCOR_27268052_Chip-Seq_Bcells_Human2.00085561
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.3020075
24PHF8_20622854_ChIP-Seq_HELA_Human1.88124458
25IRF8_22096565_ChIP-ChIP_GC-B_Human1.85584918
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.81401150
27SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.80986168
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.75885562
29TET1_21451524_ChIP-Seq_MESCs_Mouse1.75601546
30E2F1_20622854_ChIP-Seq_HELA_Human1.70550041
31* VDR_24763502_ChIP-Seq_THP-1_Human1.70222418
32SRY_22984422_ChIP-ChIP_TESTIS_Rat1.70040527
33CTCF_27219007_Chip-Seq_ERYTHROID_Human1.68779466
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.66964898
35SA1_27219007_Chip-Seq_ERYTHROID_Human1.62515986
36SMC4_20622854_ChIP-Seq_HELA_Human1.59785735
37CTCF_20526341_ChIP-Seq_ESCs_Human1.57946013
38STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.57687181
39RACK7_27058665_Chip-Seq_MCF-7_Human1.55658292
40CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.52035821
41CTCF_21964334_Chip-Seq_Bcells_Human1.50257548
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.47992342
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.47978363
44KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.41963551
45HTT_18923047_ChIP-ChIP_STHdh_Human1.41681062
46FOXA2_19822575_ChIP-Seq_HepG2_Human1.41057869
47P300_27268052_Chip-Seq_Bcells_Human1.40999009
48IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40239256
49YY1_22570637_ChIP-Seq_MALME-3M_Human1.39088513
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38632616
51* MAF_26560356_Chip-Seq_TH1_Human1.38024425
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.37538617
53MAF_26560356_Chip-Seq_TH2_Human1.36865356
54* HNF4A_19822575_ChIP-Seq_HepG2_Human1.36444892
55* XRN2_22483619_ChIP-Seq_HELA_Human1.33542560
56RXRA_24833708_ChIP-Seq_LIVER_Mouse1.30486696
57CTCF_21964334_ChIP-Seq_BJAB-B_Human1.30270885
58CTCF_18555785_ChIP-Seq_MESCs_Mouse1.27033176
59NCOR1_26117541_ChIP-Seq_K562_Human1.26496214
60CREB1_26743006_Chip-Seq_LNCaP_Human1.25828629
61BP1_19119308_ChIP-ChIP_Hs578T_Human1.25570420
62SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23470971
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23204372
64CTCF_27219007_Chip-Seq_Bcells_Human1.22504476
65* FOXP1_21924763_ChIP-Seq_HESCs_Human1.22496481
66UTX_26944678_Chip-Seq_JUKART_Human1.21872146
67ERA_21632823_ChIP-Seq_H3396_Human1.20288497
68EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.20169049
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19193536
70CTCF_26484167_Chip-Seq_Bcells_Mouse1.19050133
71CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.18457576
72RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.17774105
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17487451
74SA1_27219007_Chip-Seq_Bcells_Human1.15751284
75ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15422978
76GABP_19822575_ChIP-Seq_HepG2_Human1.14941766
77CLOCK_20551151_ChIP-Seq_293T_Human1.14784428
78ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13861050
79* TP63_22573176_ChIP-Seq_HFKS_Human1.13816194
80MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13068871
81MYC_22102868_ChIP-Seq_BL_Human1.13013971
82STAT1_20625510_ChIP-Seq_HELA_Human1.12802003
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.12137160
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11968256
85KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11859442
86RUNX1_22412390_ChIP-Seq_EML_Mouse1.10522739
87MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08839530
88E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08614433
89TP53_22127205_ChIP-Seq_IMR90_Human1.07209309
90SPI1_20517297_ChIP-Seq_HL60_Human1.06382888
91SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05678775
92TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04791925
93PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03755025
94KAP1_22055183_ChIP-Seq_ESCs_Mouse1.01872272
95SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00478744
96BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99731745
97GATA4_25053715_ChIP-Seq_YYC3_Human0.94506824
98SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.88030887
99IRF1_19129219_ChIP-ChIP_H3396_Human0.86855210
100THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.85781275
101RARA_24833708_ChIP-Seq_LIVER_Mouse0.84118114
102FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.84109329
103PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83908458
104RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.83832699
105AR_20517297_ChIP-Seq_VCAP_Human0.83262100
106STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.79815015
107PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.79396006
108* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78628958
109SCL_19346495_ChIP-Seq_HPC-7_Human0.74615894
110IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.73681193
111GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.72080237
112CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71231471
113RARB_24833708_ChIP-Seq_LIVER_Mouse0.69017461
114Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.68671059
115SRF_21415370_ChIP-Seq_HL-1_Mouse0.68164866
116NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.68051606
117FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.67734162
118RAD21_21589869_ChIP-Seq_MESCs_Mouse0.67541858
119AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.66056412
120STAT1_17558387_ChIP-Seq_HELA_Human0.65875586
121CEBPB_22108803_ChIP-Seq_LS180_Human0.65814674
122BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.64235567
123BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.63501136
124ESET_19884257_ChIP-Seq_ESCs_Mouse0.63379290
125LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.63150251
126P53_21459846_ChIP-Seq_SAOS-2_Human0.63015652
127SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.61475089
128FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.60868620
129ELF1_17652178_ChIP-ChIP_JURKAT_Human0.60017929
130ERG_20517297_ChIP-Seq_VCAP_Human0.59949600
131TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.59511881
132PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.57680341
133LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.56370337
134FOXA1_25552417_ChIP-Seq_VCAP_Human0.51992903
135CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.51541840
136PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51539539
137PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.50900175
138PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.50501357
139EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.49611094
140GATA2_22383799_ChIP-Seq_G1ME_Mouse0.49484953
141GATA1_19941827_ChIP-Seq_MEL_Mouse0.49273329
142CBP_21632823_ChIP-Seq_H3396_Human0.48750583
143MYC_19915707_ChIP-ChIP_AK7_Human0.48622494
144RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.48588944
145BRD4_27068464_Chip-Seq_AML-cells_Mouse0.48588165
146TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.48507755
147SOX2_22085726_ChIP-Seq_NPCs_Mouse0.47151513
148GATA6_25053715_ChIP-Seq_YYC3_Human0.47099490
149GATA1_22383799_ChIP-Seq_G1ME_Mouse0.45199836
150CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.44619413
151SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.44577484
152STAT3_1855785_ChIP-Seq_MESCs_Mouse0.44406410
153CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.44358552
154CRX_20693478_ChIP-Seq_RETINA_Mouse0.44339910
155FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.44069483
156NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.43875185
157CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.42901843
158TAF2_19829295_ChIP-Seq_ESCs_Human0.42653505
159SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.42011780
160BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.41822243
161SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.41771694
162SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.41441645
163NFE2_27457419_Chip-Seq_LIVER_Mouse0.41001010
164EZH2_27294783_Chip-Seq_NPCs_Mouse0.40855131
165SALL4_18804426_ChIP-ChIP_XEN_Mouse0.40845803
166SPI1_26923725_Chip-Seq_HPCs_Mouse0.40752944
167SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.40624254
168RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.40380506

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.12141537
2MP0005360_urolithiasis7.10610096
3MP0005365_abnormal_bile_salt6.32042628
4MP0005085_abnormal_gallbladder_physiolo6.16028852
5MP0008875_abnormal_xenobiotic_pharmacok4.85081814
6MP0003806_abnormal_nucleotide_metabolis3.98598210
7MP0003252_abnormal_bile_duct3.76587939
8MP0010329_abnormal_lipoprotein_level3.43769316
9MP0001666_abnormal_nutrient_absorption3.02239692
10MP0005083_abnormal_biliary_tract2.98069986
11MP0009840_abnormal_foam_cell2.95401493
12MP0008995_early_reproductive_senescence2.94289173
13MP0005332_abnormal_amino_acid2.75046487
14MP0008260_abnormal_autophagy2.60262366
15MP0003195_calcinosis2.56201924
16MP0003191_abnormal_cellular_cholesterol2.34471632
17MP0002735_abnormal_chemical_nociception2.28186971
18MP0003868_abnormal_feces_composition2.17919469
19MP0000609_abnormal_liver_physiology2.14690280
20MP0003172_abnormal_lysosome_physiology2.12008325
21MP0002118_abnormal_lipid_homeostasis2.10961544
22MP0004019_abnormal_vitamin_homeostasis2.04924474
23MP0000015_abnormal_ear_pigmentation2.04168119
24MP0002148_abnormal_hypersensitivity_rea2.02607106
25MP0002138_abnormal_hepatobiliary_system1.99026167
26MP0009697_abnormal_copulation1.94411906
27MP0009278_abnormal_bone_marrow1.91377592
28MP0005171_absent_coat_pigmentation1.87324844
29MP0001764_abnormal_homeostasis1.86992214
30MP0005319_abnormal_enzyme/_coenzyme1.81599668
31MP0001545_abnormal_hematopoietic_system1.68493607
32MP0005397_hematopoietic_system_phenotyp1.68493607
33MP0003075_altered_response_to1.66994011
34MP0003828_pulmonary_edema1.60757237
35MP0003186_abnormal_redox_activity1.53727797
36MP0000678_abnormal_parathyroid_gland1.53435248
37MP0000516_abnormal_urinary_system1.50869159
38MP0005367_renal/urinary_system_phenotyp1.50869159
39MP0005584_abnormal_enzyme/coenzyme_acti1.48796143
40MP0001873_stomach_inflammation1.44661943
41MP0003303_peritoneal_inflammation1.41518274
42MP0009643_abnormal_urine_homeostasis1.40319006
43MP0005501_abnormal_skin_physiology1.38017355
44MP0005646_abnormal_pituitary_gland1.36228774
45MP0005647_abnormal_sex_gland1.33201240
46MP0000465_gastrointestinal_hemorrhage1.31022301
47MP0002249_abnormal_larynx_morphology1.28164507
48MP0005451_abnormal_body_composition1.27482510
49MP0005220_abnormal_exocrine_pancreas1.25591363
50MP0003011_delayed_dark_adaptation1.24474955
51MP0000598_abnormal_liver_morphology1.24353976
52MP0005084_abnormal_gallbladder_morpholo1.20137461
53MP0000372_irregular_coat_pigmentation1.19478156
54MP0003656_abnormal_erythrocyte_physiolo1.19138322
55MP0005670_abnormal_white_adipose1.18907319
56MP0003183_abnormal_peptide_metabolism1.17116177
57MP0009764_decreased_sensitivity_to1.12762260
58MP0001835_abnormal_antigen_presentation1.12606913
59MP0003786_premature_aging1.10671372
60MP0006082_CNS_inflammation1.09803569
61MP0009333_abnormal_splenocyte_physiolog1.08809649
62MP0005636_abnormal_mineral_homeostasis1.05390507
63MP0009763_increased_sensitivity_to1.02220832
64MP0006036_abnormal_mitochondrial_physio1.00111904
65MP0008469_abnormal_protein_level0.99918800
66MP0005503_abnormal_tendon_morphology0.99795463
67MP0000681_abnormal_thyroid_gland0.99440770
68MP0005174_abnormal_tail_pigmentation0.97062994
69MP0003453_abnormal_keratinocyte_physiol0.93971722
70MP0009642_abnormal_blood_homeostasis0.93500075
71MP0001919_abnormal_reproductive_system0.92284525
72MP0000858_altered_metastatic_potential0.91507287
73MP0002876_abnormal_thyroid_physiology0.91456731
74MP0004185_abnormal_adipocyte_glucose0.89997704
75MP0002452_abnormal_antigen_presenting0.88101975
76MP0000343_altered_response_to0.88069355
77MP0005389_reproductive_system_phenotype0.86877583
78MP0009765_abnormal_xenobiotic_induced0.86677197
79MP0002078_abnormal_glucose_homeostasis0.86416949
80MP0005423_abnormal_somatic_nervous0.86158622
81MP0002723_abnormal_immune_serum0.86085318
82MP0003698_abnormal_male_reproductive0.85116461
83MP0005408_hypopigmentation0.84490705
84MP0002822_catalepsy0.82162091
85MP0005330_cardiomyopathy0.81749719
86MP0005334_abnormal_fat_pad0.81290542
87MP0002796_impaired_skin_barrier0.80377631
88MP0010368_abnormal_lymphatic_system0.78722657
89MP0005165_increased_susceptibility_to0.77825233
90MP0003705_abnormal_hypodermis_morpholog0.77614712
91MP0002127_abnormal_cardiovascular_syste0.77031730
92MP0005310_abnormal_salivary_gland0.76616505
93MP0001348_abnormal_lacrimal_gland0.75489581
94MP0005464_abnormal_platelet_physiology0.73428072
95MP0001790_abnormal_immune_system0.73353313
96MP0005387_immune_system_phenotype0.73353313
97MP0005376_homeostasis/metabolism_phenot0.72707878
98MP0002254_reproductive_system_inflammat0.72462115
99MP0002160_abnormal_reproductive_system0.72298940
100MP0002971_abnormal_brown_adipose0.69021412
101MP0002928_abnormal_bile_duct0.68887157
102MP0000604_amyloidosis0.66713579
103MP0005535_abnormal_body_temperature0.66059001
104MP0001756_abnormal_urination0.65183536
105MP0005448_abnormal_energy_balance0.63916631
106MP0003724_increased_susceptibility_to0.63203020
107MP0001661_extended_life_span0.62943055
108MP0004782_abnormal_surfactant_physiolog0.60168988
109MP0004130_abnormal_muscle_cell0.57431220
110MP0001853_heart_inflammation0.57353217
111MP0006035_abnormal_mitochondrial_morpho0.57131448
112MP0005266_abnormal_metabolism0.56669389
113MP0002136_abnormal_kidney_physiology0.55960818
114MP0002132_abnormal_respiratory_system0.54169606
115MP0003436_decreased_susceptibility_to0.52988225
116MP0005410_abnormal_fertilization0.52045161
117MP0004264_abnormal_extraembryonic_tissu0.51037901
118MP0003953_abnormal_hormone_level0.50646987
119MP0000566_synostosis0.49609299
120MP0001845_abnormal_inflammatory_respons0.47833786
121MP0000639_abnormal_adrenal_gland0.46492506
122MP0009115_abnormal_fat_cell0.46054625
123MP0001944_abnormal_pancreas_morphology0.45396020
124MP0003638_abnormal_response/metabolism_0.45062397
125MP0002166_altered_tumor_susceptibility0.41638480
126MP0005666_abnormal_adipose_tissue0.41436005
127MP0008873_increased_physiological_sensi0.41415001
128MP0002970_abnormal_white_adipose0.40907522
129MP0005075_abnormal_melanosome_morpholog0.40816640
130MP0004043_abnormal_pH_regulation0.38954776
131MP0009672_abnormal_birth_weight0.38113399
132MP0009785_altered_susceptibility_to0.37497749
133MP0005058_abnormal_lysosome_morphology0.34816571
134MP0003718_maternal_effect0.34445304
135MP0002693_abnormal_pancreas_physiology0.33749561
136MP0005395_other_phenotype0.33651519
137MP0000249_abnormal_blood_vessel0.33608418
138MP0003959_abnormal_lean_body0.33594543
139MP0005166_decreased_susceptibility_to0.32633392
140MP0002060_abnormal_skin_morphology0.32136437
141MP0004381_abnormal_hair_follicle0.31985623
142MP0000579_abnormal_nail_morphology0.31811087
143MP0003690_abnormal_glial_cell0.31804809
144MP0005025_abnormal_response_to0.31415481
145MP0001881_abnormal_mammary_gland0.31334234
146MP0001765_abnormal_ion_homeostasis0.31300285
147MP0003943_abnormal_hepatobiliary_system0.30834537
148MP0002135_abnormal_kidney_morphology0.29611373
149MP0002419_abnormal_innate_immunity0.29571690
150MP0005248_abnormal_Harderian_gland0.29495569

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.33915662
2Intrahepatic cholestasis (HP:0001406)6.79047533
3Deep venous thrombosis (HP:0002625)6.45275391
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.37192265
5Prolonged partial thromboplastin time (HP:0003645)6.33888869
6Hypobetalipoproteinemia (HP:0003563)5.96428140
7Male infertility (HP:0003251)5.91408812
8Xanthomatosis (HP:0000991)5.63402109
9Hyperlipoproteinemia (HP:0010980)5.47166250
10Complement deficiency (HP:0004431)4.72858691
11Joint hemorrhage (HP:0005261)4.68281888
12Hypoglycemic coma (HP:0001325)4.61982381
13Hyperammonemia (HP:0001987)4.53301929
14Hypolipoproteinemia (HP:0010981)4.47337411
15Ketosis (HP:0001946)4.40516167
16Hyperglycinemia (HP:0002154)4.39049425
17Abnormality of the common coagulation pathway (HP:0010990)4.36083184
18Abnormality of methionine metabolism (HP:0010901)4.30962258
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.22979169
20Rhinitis (HP:0012384)4.20157503
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.18768921
22Fat malabsorption (HP:0002630)4.17629931
23Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.12327086
24Abnormality of aspartate family amino acid metabolism (HP:0010899)4.10733958
25Abnormality of the intrinsic pathway (HP:0010989)4.06631010
26Hyperglycinuria (HP:0003108)4.05092037
27Abnormality of pyrimidine metabolism (HP:0004353)4.03407067
28Epidermoid cyst (HP:0200040)3.98727020
29Conjugated hyperbilirubinemia (HP:0002908)3.96233006
30Hypoalphalipoproteinemia (HP:0003233)3.93134360
31Abnormality of serine family amino acid metabolism (HP:0010894)3.89503857
32Abnormality of glycine metabolism (HP:0010895)3.89503857
33Abnormality of glutamine family amino acid metabolism (HP:0010902)3.89254651
34Dynein arm defect of respiratory motile cilia (HP:0012255)3.86726972
35Absent/shortened dynein arms (HP:0200106)3.86726972
36Abnormal ciliary motility (HP:0012262)3.85374912
37Abnormal respiratory motile cilium morphology (HP:0005938)3.84009320
38Abnormal respiratory epithelium morphology (HP:0012253)3.84009320
39Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.77153588
40Abnormal respiratory motile cilium physiology (HP:0012261)3.76471102
41Abnormality of fatty-acid metabolism (HP:0004359)3.65167829
42Stridor (HP:0010307)3.53319165
43Hyperbilirubinemia (HP:0002904)3.45673127
44Mesangial abnormality (HP:0001966)3.45634427
45Abnormality of complement system (HP:0005339)3.37669586
46Hypercholesterolemia (HP:0003124)3.36078050
47Steatorrhea (HP:0002570)3.31827336
48Abnormality of nucleobase metabolism (HP:0010932)3.28146835
49Hypoglycemic seizures (HP:0002173)3.22014510
50Infertility (HP:0000789)3.18118705
51Abnormality of serum amino acid levels (HP:0003112)3.14206164
52Ketoacidosis (HP:0001993)3.13378252
53Failure to thrive in infancy (HP:0001531)3.13201695
54Nasal polyposis (HP:0100582)3.09912836
55Renal Fanconi syndrome (HP:0001994)3.07761143
56Diaphragmatic weakness (HP:0009113)2.96397156
57Delayed CNS myelination (HP:0002188)2.90861601
58Abnormality of purine metabolism (HP:0004352)2.90516720
59Dry hair (HP:0011359)2.88030344
60Metabolic acidosis (HP:0001942)2.87805297
61Dicarboxylic aciduria (HP:0003215)2.87419615
62Abnormality of dicarboxylic acid metabolism (HP:0010995)2.87419615
63Abnormality of the nasal mucosa (HP:0000433)2.86780900
64Recurrent sinusitis (HP:0011108)2.82888316
65Hyperinsulinemic hypoglycemia (HP:0000825)2.74225792
66Myocardial infarction (HP:0001658)2.72148704
67Hepatocellular carcinoma (HP:0001402)2.69648961
68Gout (HP:0001997)2.68594009
69Bronchiectasis (HP:0002110)2.68210877
70Gonadal dysgenesis (HP:0000133)2.66929625
71Spontaneous abortion (HP:0005268)2.66115043
72Testicular atrophy (HP:0000029)2.64347752
73Prolonged neonatal jaundice (HP:0006579)2.60948794
74Lethargy (HP:0001254)2.59877110
75Vascular calcification (HP:0004934)2.58406359
76Chronic bronchitis (HP:0004469)2.57706162
77Generalized aminoaciduria (HP:0002909)2.57460460
78Renal cortical cysts (HP:0000803)2.54709819
79Hypochromic microcytic anemia (HP:0004840)2.53896732
80Atelectasis (HP:0100750)2.49626282
81Abnormality of glycolipid metabolism (HP:0010969)2.48633313
82Abnormality of liposaccharide metabolism (HP:0010968)2.48633313
83Abnormality of glycosphingolipid metabolism (HP:0004343)2.48633313
84Systemic lupus erythematosus (HP:0002725)2.46675389
85Increased muscle lipid content (HP:0009058)2.45157734
86Late onset (HP:0003584)2.43474285
87Cerebral edema (HP:0002181)2.39807909
88Skin nodule (HP:0200036)2.38385699
89Enlarged kidneys (HP:0000105)2.38336531
90Vacuolated lymphocytes (HP:0001922)2.37837185
91Pancreatitis (HP:0001733)2.37404483
92Brushfield spots (HP:0001088)2.36645066
93Abnormality of glycosaminoglycan metabolism (HP:0004371)2.33185764
94Abnormality of mucopolysaccharide metabolism (HP:0011020)2.33185764
95Abnormality of polysaccharide metabolism (HP:0011012)2.33185764
96Type I transferrin isoform profile (HP:0003642)2.32132828
97Dysostosis multiplex (HP:0000943)2.31102660
98Acanthocytosis (HP:0001927)2.29311556
99Symptomatic seizures (HP:0011145)2.26895269
100Recurrent gram-negative bacterial infections (HP:0005420)2.25987953
101Testicular neoplasm (HP:0010788)2.25980960
102Agnosia (HP:0010524)2.25537004
103Cardiovascular calcification (HP:0011915)2.24806541
104Hyperthyroidism (HP:0000836)2.24382900
105Decreased electroretinogram (ERG) amplitude (HP:0000654)2.23107957
106Abnormal gallbladder morphology (HP:0012437)2.22374571
107Increased intramyocellular lipid droplets (HP:0012240)2.21967184
108Gingival bleeding (HP:0000225)2.21356647
109Opisthotonus (HP:0002179)2.21344134
110Increased cerebral lipofuscin (HP:0011813)2.19833515
111Menorrhagia (HP:0000132)2.19155464
112Increased neuronal autofluorescent lipopigment (HP:0002074)2.17762941
113Bulbar palsy (HP:0001283)2.14972358
114Malnutrition (HP:0004395)2.14948062
115Mucopolysacchariduria (HP:0008155)2.12574822
116Urinary glycosaminoglycan excretion (HP:0003541)2.12574822
117Elevated hepatic transaminases (HP:0002910)2.12555956
118Cholelithiasis (HP:0001081)2.12514856
119Irritability (HP:0000737)2.12052561
120Vomiting (HP:0002013)2.11407002
121Mitral stenosis (HP:0001718)2.09976469
122Spastic diplegia (HP:0001264)2.06361258
123Hypoplastic heart (HP:0001961)2.05125129
124Decreased circulating renin level (HP:0003351)2.03878732
125Neonatal onset (HP:0003623)2.03630342
126Hemorrhage of the eye (HP:0011885)2.02874925
127Hypoplastic left heart (HP:0004383)2.02546233
128Severe visual impairment (HP:0001141)2.02394826
129Proximal tubulopathy (HP:0000114)2.02075786
130Elevated erythrocyte sedimentation rate (HP:0003565)2.01625448
131Hand muscle atrophy (HP:0009130)2.01494812
132Abnormal ventriculo-arterial connection (HP:0011563)2.00739121
133Transposition of the great arteries (HP:0001669)2.00739121
134Abnormal connection of the cardiac segments (HP:0011545)2.00739121
135Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.00387997
136Thrombophlebitis (HP:0004418)2.00251775
137Esophageal varix (HP:0002040)1.99797179
138Chronic obstructive pulmonary disease (HP:0006510)1.99049763
139Obstructive lung disease (HP:0006536)1.99049763
140Hyperuricemia (HP:0002149)1.97942753
141Increased purine levels (HP:0004368)1.97942753
142Chronic hepatic failure (HP:0100626)1.97357539
143Abnormal gallbladder physiology (HP:0012438)1.96908421
144Cholecystitis (HP:0001082)1.96908421
145Amaurosis fugax (HP:0100576)1.96878245
146Sensorimotor neuropathy (HP:0007141)1.96861123
147Seborrheic dermatitis (HP:0001051)1.96687069
148Hypertensive crisis (HP:0100735)1.96646572
149Dyschromatopsia (HP:0007641)1.91400563
150Alkalosis (HP:0001948)1.90942757
151Mediastinal lymphadenopathy (HP:0100721)1.90687628
152Glomerulonephritis (HP:0000099)1.90455987
153Progressive neurologic deterioration (HP:0002344)1.88717704
154Rough bone trabeculation (HP:0100670)1.88309191
155Acute hepatic failure (HP:0006554)1.88084426
156Abnormality of renal resorption (HP:0011038)1.85739349
157Colitis (HP:0002583)1.85050001
158Ependymoma (HP:0002888)1.84875942
159Abnormality of the aortic arch (HP:0012303)1.84161525
160Glycosuria (HP:0003076)1.83929985
161Abnormality of urine glucose concentration (HP:0011016)1.83929985
162Abnormal enzyme/coenzyme activity (HP:0012379)1.82723410
163Abnormal protein glycosylation (HP:0012346)1.82524334
164Abnormal glycosylation (HP:0012345)1.82524334
165Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.82524334
166Abnormal protein N-linked glycosylation (HP:0012347)1.82524334
167Abnormality of the gallbladder (HP:0005264)1.80873815
168Poikilocytosis (HP:0004447)1.80517705
169Recurrent cutaneous fungal infections (HP:0011370)1.80144286
170Chronic mucocutaneous candidiasis (HP:0002728)1.80144286
171Male pseudohermaphroditism (HP:0000037)1.80044258
172Atrioventricular block (HP:0001678)1.79775189
173Death in childhood (HP:0003819)1.79388005
174Epiphyseal stippling (HP:0010655)1.78388336
175Amyloidosis (HP:0011034)1.78333590
176Albinism (HP:0001022)1.78212053
177Petechiae (HP:0000967)1.77604609
178Abnormal cartilage morphology (HP:0002763)1.77547405
179Abnormality of transition element cation homeostasis (HP:0011030)1.77333153
180Abnormal trabecular bone morphology (HP:0100671)1.76327424
181Abnormal delayed hypersensitivity skin test (HP:0002963)1.76259963
182Ragged-red muscle fibers (HP:0003200)1.76022982
183Attenuation of retinal blood vessels (HP:0007843)1.75923927

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.13180127
2ERN14.22502187
3VRK24.11555047
4SMG13.99015852
5PIM23.68905679
6TAOK33.66813371
7INSRR3.56201972
8FGFR43.47573487
9SIK13.44040705
10TRIM282.97107161
11FLT32.61841730
12TAF12.60748102
13IRAK32.51642860
14FRK2.31187339
15PIK3CG2.28301365
16TYK22.06486110
17EPHA21.93446033
18ARAF1.90321734
19PAK41.78987565
20ERBB41.76707238
21TESK11.61080576
22PDK31.58794914
23PDK41.58794914
24MST1R1.58394101
25MAPK111.57145974
26NEK91.56684677
27TNK21.56417945
28MAP4K21.51825664
29PKN21.41089064
30MAPK151.37847647
31BMPR21.35061944
32TESK21.31014817
33MAP3K141.25600970
34TAOK11.25510991
35TLK11.21558184
36PRPF4B1.19276069
37PRKD21.18399400
38MAP2K31.17137449
39ABL21.17065419
40CSNK1A1L1.14627011
41TBK11.14100851
42STK161.13854038
43MAP3K111.13246704
44LATS11.08779392
45DAPK31.06625315
46CSNK1G31.06270824
47MAPKAPK31.05392678
48DAPK11.04310627
49MAP2K41.03155478
50KIT0.98920427
51BRAF0.98349872
52MAP2K60.97869106
53PRKAA20.97506914
54BLK0.96252440
55ACVR1B0.95455676
56ICK0.95144164
57JAK20.93996798
58FGFR20.93194081
59PDPK10.92919894
60JAK10.90996155
61CSF1R0.90342580
62PRKCI0.90177765
63BTK0.90036761
64TAOK20.89812144
65TRIB30.88788344
66PTK60.88202153
67VRK10.87343858
68STK38L0.85725351
69HIPK20.85506301
70TEC0.84826867
71PRKD30.82819677
72PINK10.82362330
73PDK20.81518613
74MAP4K10.80193214
75KDR0.79266911
76SIK20.77521690
77GRK60.75668164
78TIE10.74083301
79BMPR1B0.73419616
80STK380.73309258
81JAK30.73161372
82MAPK40.72431647
83MAP3K70.71758939
84IKBKE0.70996637
85FER0.70814397
86NLK0.70363625
87IRAK10.69806532
88MAP3K30.69626893
89RPS6KA50.65255036
90CDK60.64644771
91TGFBR20.64567416
92MAPK70.63837609
93GRK50.63528942
94DYRK1B0.63176497
95ZAP700.61091746
96AKT30.61025064
97PRKAA10.60619980
98IRAK40.60006108
99RPS6KC10.59494245
100RPS6KL10.59494245
101EIF2AK30.58780721
102MAP2K20.58674744
103GRK70.57432378
104GRK10.56630153
105EPHA30.56503941
106PIK3CA0.56084819
107SGK20.55869852
108MAP3K100.55638351
109FGFR30.55581379
110PDK10.55273373
111RPS6KA60.54700770
112CDK40.54550200
113RIPK10.54375102
114MYLK0.54326633
115PRKACG0.52417395
116CHUK0.52335109
117CAMKK20.52221970
118SGK30.51447026
119ERBB20.49853331
120ADRBK20.49827432
121ITK0.49813631
122MARK30.49402008
123RPS6KA20.49249439
124MARK20.48303509
125TXK0.48035355
126CSNK1G20.46910276
127MAPK120.46412504
128EPHB10.45662278
129PRKCZ0.45328341
130CSNK1G10.45312652
131RPS6KA40.44957843
132CSK0.44779934
133BRSK20.43953750
134FES0.42898146
135CDK90.42363025
136STK100.41871683
137NME20.41666937
138IGF1R0.41019797
139MAPKAPK50.40567709
140MAP3K10.40107442
141EEF2K0.39970026
142CCNB10.39142628
143STK110.38797242
144PIM10.38604228
145MAP3K50.37701679
146MATK0.37445576
147PRKCQ0.36124994
148MAP3K60.35951288
149RPS6KB10.35915925
150IKBKB0.35036749
151IRAK20.34960123
152GSK3A0.34342187
153AURKA0.34219772
154MAPK30.33920824
155TGFBR10.33150704
156CDK70.32301151
157CAMK1D0.31703372
158CAMK2G0.31263598
159STK30.31094523
160MET0.30752471
161PRKCD0.29562488
162MUSK0.28918642
163MTOR0.28871017
164CAMK1G0.28651470
165RAF10.28184157

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.25895311
2Asthma_Homo sapiens_hsa053103.66744040
3Nitrogen metabolism_Homo sapiens_hsa009103.29490322
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.21532923
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.80984274
6Arginine biosynthesis_Homo sapiens_hsa002202.80836883
7Tryptophan metabolism_Homo sapiens_hsa003802.70009971
8Fatty acid degradation_Homo sapiens_hsa000712.63131875
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.61723177
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.52229167
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.51767778
12Complement and coagulation cascades_Homo sapiens_hsa046102.49567358
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.47307690
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.23779502
15* Peroxisome_Homo sapiens_hsa041462.19282106
16Propanoate metabolism_Homo sapiens_hsa006402.15158121
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.14605514
18Chemical carcinogenesis_Homo sapiens_hsa052041.94731163
19Butanoate metabolism_Homo sapiens_hsa006501.94218945
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.91046227
21Histidine metabolism_Homo sapiens_hsa003401.90860740
22PPAR signaling pathway_Homo sapiens_hsa033201.88072068
23Fatty acid metabolism_Homo sapiens_hsa012121.86349291
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.85901698
25Selenocompound metabolism_Homo sapiens_hsa004501.83836628
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.81623118
27beta-Alanine metabolism_Homo sapiens_hsa004101.77034714
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.76763515
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.74159558
30Retinol metabolism_Homo sapiens_hsa008301.67436591
31Caffeine metabolism_Homo sapiens_hsa002321.67297507
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.60711504
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.58734506
34Sulfur metabolism_Homo sapiens_hsa009201.58669525
35Staphylococcus aureus infection_Homo sapiens_hsa051501.53972093
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.47208563
37Folate biosynthesis_Homo sapiens_hsa007901.46930357
38Pyruvate metabolism_Homo sapiens_hsa006201.45630911
39Lysosome_Homo sapiens_hsa041421.43229826
40Phenylalanine metabolism_Homo sapiens_hsa003601.42193493
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.38788915
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.38741359
43Fatty acid elongation_Homo sapiens_hsa000621.38522826
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37035410
45Allograft rejection_Homo sapiens_hsa053301.35129891
46Tyrosine metabolism_Homo sapiens_hsa003501.34637129
47Fat digestion and absorption_Homo sapiens_hsa049751.33897394
48Autoimmune thyroid disease_Homo sapiens_hsa053201.33729693
49Starch and sucrose metabolism_Homo sapiens_hsa005001.27947471
50Bile secretion_Homo sapiens_hsa049761.26927356
51Base excision repair_Homo sapiens_hsa034101.26628640
52ABC transporters_Homo sapiens_hsa020101.25791142
53Biosynthesis of amino acids_Homo sapiens_hsa012301.19136372
54Steroid biosynthesis_Homo sapiens_hsa001001.18736091
55SNARE interactions in vesicular transport_Homo sapiens_hsa041301.17471968
56Carbon metabolism_Homo sapiens_hsa012001.16410054
57Sulfur relay system_Homo sapiens_hsa041221.15967958
58Leishmaniasis_Homo sapiens_hsa051401.14844473
59Sphingolipid metabolism_Homo sapiens_hsa006001.14597004
60Vitamin digestion and absorption_Homo sapiens_hsa049771.07327490
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.06591549
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06373394
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02557472
64Vitamin B6 metabolism_Homo sapiens_hsa007501.00502020
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00168611
66Arginine and proline metabolism_Homo sapiens_hsa003300.99711168
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.96358781
68One carbon pool by folate_Homo sapiens_hsa006700.93067474
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89776179
70Lysine degradation_Homo sapiens_hsa003100.86582675
71Graft-versus-host disease_Homo sapiens_hsa053320.83501304
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82762264
73Huntingtons disease_Homo sapiens_hsa050160.82332476
74Glycerolipid metabolism_Homo sapiens_hsa005610.77598829
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76661041
76Glutathione metabolism_Homo sapiens_hsa004800.76360366
77Pentose phosphate pathway_Homo sapiens_hsa000300.69003405
78Antigen processing and presentation_Homo sapiens_hsa046120.66480906
79Type I diabetes mellitus_Homo sapiens_hsa049400.63954931
80Fatty acid biosynthesis_Homo sapiens_hsa000610.62003089
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61422128
82Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59264510
83Tuberculosis_Homo sapiens_hsa051520.59107036
84Oxidative phosphorylation_Homo sapiens_hsa001900.57887800
85Metabolic pathways_Homo sapiens_hsa011000.55951705
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52917774
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50444897
88Hematopoietic cell lineage_Homo sapiens_hsa046400.50239969
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48293579
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47767948
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47165772
92Rheumatoid arthritis_Homo sapiens_hsa053230.43434782
93Galactose metabolism_Homo sapiens_hsa000520.42449068
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.41063338
95Fructose and mannose metabolism_Homo sapiens_hsa000510.40738190
96Linoleic acid metabolism_Homo sapiens_hsa005910.40429912
97Herpes simplex infection_Homo sapiens_hsa051680.37932669
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.37840125
99Pertussis_Homo sapiens_hsa051330.36733058
100Influenza A_Homo sapiens_hsa051640.36047949
101Toxoplasmosis_Homo sapiens_hsa051450.33276387
102Bladder cancer_Homo sapiens_hsa052190.32318587
103Ribosome_Homo sapiens_hsa030100.29771125
104Protein export_Homo sapiens_hsa030600.26627147
105Insulin resistance_Homo sapiens_hsa049310.20769064
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.19674897
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.15714814
108Glucagon signaling pathway_Homo sapiens_hsa049220.15682183
109Prion diseases_Homo sapiens_hsa050200.14940297
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.13359308
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.12568064
112Glycosaminoglycan degradation_Homo sapiens_hsa005310.09657566
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.06609651
114Arachidonic acid metabolism_Homo sapiens_hsa005900.04580915
115N-Glycan biosynthesis_Homo sapiens_hsa005100.00568360
116Protein digestion and absorption_Homo sapiens_hsa04974-0.1750289
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1725353
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563-0.1690288
119Insulin signaling pathway_Homo sapiens_hsa04910-0.1613585
120Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.1517412
121Hepatitis C_Homo sapiens_hsa05160-0.1490727
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.1451123
123Legionellosis_Homo sapiens_hsa05134-0.1360742
124Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1250488
125Renin-angiotensin system_Homo sapiens_hsa04614-0.0978144
126Other glycan degradation_Homo sapiens_hsa00511-0.0635829
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0575588
128AMPK signaling pathway_Homo sapiens_hsa04152-0.0497589
129Regulation of autophagy_Homo sapiens_hsa04140-0.0363608
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0350634
131Pyrimidine metabolism_Homo sapiens_hsa00240-0.0175877

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