PEX12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the peroxin-12 family. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of Zellweger syndrome (ZWS). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of mitotic metaphase/anaphase transition (GO:0045842)7.29066089
2positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)7.29066089
3positive regulation of mitotic sister chromatid separation (GO:1901970)7.29066089
4protein prenylation (GO:0018342)6.21475718
5prenylation (GO:0097354)6.21475718
6regulation of sister chromatid cohesion (GO:0007063)5.21374854
7positive regulation of chromosome segregation (GO:0051984)5.05265392
8negative regulation of Ras GTPase activity (GO:0034261)4.75779320
9peptidyl-lysine dimethylation (GO:0018027)4.63261391
10coenzyme A biosynthetic process (GO:0015937)4.33673487
11negative regulation of peptidyl-threonine phosphorylation (GO:0010801)4.31237362
12synapsis (GO:0007129)4.25309850
13positive regulation of mitochondrial fission (GO:0090141)4.13755944
14protein deneddylation (GO:0000338)4.11450551
15fucose catabolic process (GO:0019317)4.11166526
16L-fucose metabolic process (GO:0042354)4.11166526
17L-fucose catabolic process (GO:0042355)4.11166526
18chromosome organization involved in meiosis (GO:0070192)4.02463816
19DNA methylation involved in gamete generation (GO:0043046)3.91267744
20cullin deneddylation (GO:0010388)3.90957919
21vesicle fusion (GO:0006906)3.90362142
22COPI coating of Golgi vesicle (GO:0048205)3.87125222
23Golgi transport vesicle coating (GO:0048200)3.87125222
24branch elongation of an epithelium (GO:0060602)3.76203822
25oxidative demethylation (GO:0070989)3.75914152
26COPII vesicle coating (GO:0048208)3.72206543
27acrosome assembly (GO:0001675)3.67765485
28preassembly of GPI anchor in ER membrane (GO:0016254)3.67127733
29synaptonemal complex organization (GO:0070193)3.65865551
30male meiosis I (GO:0007141)3.56961296
31ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.54622901
32nucleoside bisphosphate biosynthetic process (GO:0033866)3.54622901
33purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.54622901
34regulation of mononuclear cell migration (GO:0071675)3.54015379
35RNA methylation (GO:0001510)3.51276333
36piRNA metabolic process (GO:0034587)3.49318267
37nucleobase biosynthetic process (GO:0046112)3.46447192
38eosinophil chemotaxis (GO:0048245)3.41749447
39DNA deamination (GO:0045006)3.41680344
40regulation of meiosis I (GO:0060631)3.39467178
41regulation of beta-amyloid formation (GO:1902003)3.38378326
42negative regulation of circadian rhythm (GO:0042754)3.37421131
43maturation of SSU-rRNA (GO:0030490)3.36906073
44coenzyme A metabolic process (GO:0015936)3.35633434
45negative regulation of T cell receptor signaling pathway (GO:0050860)3.32364758
46purine nucleobase biosynthetic process (GO:0009113)3.31696467
47rRNA modification (GO:0000154)3.29474559
48meiotic chromosome segregation (GO:0045132)3.29394347
49establishment of mitotic spindle orientation (GO:0000132)3.29255447
50ribosome biogenesis (GO:0042254)3.29083189
51histone H3-K9 demethylation (GO:0033169)3.28279561
52chromatin remodeling at centromere (GO:0031055)3.25823228
53regulation of skeletal muscle contraction (GO:0014819)3.25602034
54mitotic metaphase plate congression (GO:0007080)3.24035355
55CENP-A containing nucleosome assembly (GO:0034080)3.23829878
56double-strand break repair via nonhomologous end joining (GO:0006303)3.20792992
57non-recombinational repair (GO:0000726)3.20792992
58folic acid metabolic process (GO:0046655)3.19654140
59rRNA methylation (GO:0031167)3.19227887
60attachment of spindle microtubules to kinetochore (GO:0008608)3.19009186
61ribosomal large subunit biogenesis (GO:0042273)3.18474576
62acrosome reaction (GO:0007340)3.17530734
63water-soluble vitamin biosynthetic process (GO:0042364)3.16540330
64erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.15949777
65L-phenylalanine metabolic process (GO:0006558)3.15949777
66serine family amino acid biosynthetic process (GO:0009070)3.14849207
67male meiosis (GO:0007140)3.14232846
68L-serine metabolic process (GO:0006563)3.13993879
69proteasome assembly (GO:0043248)3.09593682
70glycine metabolic process (GO:0006544)3.07374939
71folic acid-containing compound biosynthetic process (GO:0009396)3.05864330
72mitochondrial RNA metabolic process (GO:0000959)3.03999484
73ribonucleoprotein complex biogenesis (GO:0022613)3.03508264
74eosinophil migration (GO:0072677)3.00157785
75pteridine-containing compound biosynthetic process (GO:0042559)2.99001951
76L-phenylalanine catabolic process (GO:0006559)2.98690252
77erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.98690252
78establishment of mitotic spindle localization (GO:0040001)2.98268685
79sperm-egg recognition (GO:0035036)2.97279474
80establishment of spindle orientation (GO:0051294)2.95876759
81iron-sulfur cluster assembly (GO:0016226)2.94078400
82metallo-sulfur cluster assembly (GO:0031163)2.94078400
83mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.91961617
84mitochondrial respiratory chain complex I assembly (GO:0032981)2.91961617
85NADH dehydrogenase complex assembly (GO:0010257)2.91961617
86ER to Golgi vesicle-mediated transport (GO:0006888)2.91920645
87histone exchange (GO:0043486)2.91011721
88meiosis I (GO:0007127)2.88312466
89C-terminal protein lipidation (GO:0006501)2.87789275
90binding of sperm to zona pellucida (GO:0007339)2.87620585
91meiotic nuclear division (GO:0007126)2.86282625
92protein K6-linked ubiquitination (GO:0085020)2.85342766
93nuclear pore organization (GO:0006999)2.83807928
94urea cycle (GO:0000050)2.83627942
95urea metabolic process (GO:0019627)2.83627942
96formation of translation preinitiation complex (GO:0001731)2.82786129
97regulation of spindle organization (GO:0090224)2.81693749
98peptidyl-glutamic acid carboxylation (GO:0017187)2.80512334
99protein carboxylation (GO:0018214)2.80512334
100DNA synthesis involved in DNA repair (GO:0000731)2.80279452
101DNA replication-independent nucleosome organization (GO:0034724)2.80260564
102DNA replication-independent nucleosome assembly (GO:0006336)2.80260564
103cellular component biogenesis (GO:0044085)2.79227831
104metaphase plate congression (GO:0051310)2.78794647
105ubiquinone biosynthetic process (GO:0006744)2.78688192
106quinone biosynthetic process (GO:1901663)2.78688192
107negative regulation of DNA-templated transcription, elongation (GO:0032785)2.77336308
108negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.77336308
109organelle fusion (GO:0048284)2.75948925
110axis elongation (GO:0003401)2.75799352
111tetrahydrofolate metabolic process (GO:0046653)2.75658252
112aromatic amino acid family catabolic process (GO:0009074)2.75536211
113negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.74708426
114negative regulation of sister chromatid segregation (GO:0033046)2.74708426
115negative regulation of mitotic sister chromatid separation (GO:2000816)2.74708426
116negative regulation of mitotic sister chromatid segregation (GO:0033048)2.74708426
117misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.74303584
118ribosome assembly (GO:0042255)2.73800435
119lysine catabolic process (GO:0006554)2.72832766
120lysine metabolic process (GO:0006553)2.72832766
121regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.72690015
122serine family amino acid metabolic process (GO:0009069)2.72462008
123negative regulation of chromosome segregation (GO:0051985)2.70662363
124negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.69212478
125regulation of mitochondrial fission (GO:0090140)2.68193372
126serine family amino acid catabolic process (GO:0009071)2.67753193
127folic acid-containing compound metabolic process (GO:0006760)2.66475446
128histone H3-K9 methylation (GO:0051567)2.65915341
129one-carbon metabolic process (GO:0006730)2.65873861
130ubiquinone metabolic process (GO:0006743)2.65729663
131tryptophan metabolic process (GO:0006568)2.65319227
132somatic hypermutation of immunoglobulin genes (GO:0016446)2.65239015
133somatic diversification of immune receptors via somatic mutation (GO:0002566)2.65239015
134cell-cell recognition (GO:0009988)2.65115921
135nitrogen cycle metabolic process (GO:0071941)2.64962529
136mitotic chromosome condensation (GO:0007076)2.63842606
137lipid particle organization (GO:0034389)2.63760429
138L-methionine salvage (GO:0071267)2.62596542
139L-methionine biosynthetic process (GO:0071265)2.62596542
140amino acid salvage (GO:0043102)2.62596542
141cysteine metabolic process (GO:0006534)2.62566929
142mitotic spindle assembly checkpoint (GO:0007094)2.62334452
143response to nitrosative stress (GO:0051409)2.61840339
144rRNA processing (GO:0006364)2.61286550
145indole-containing compound catabolic process (GO:0042436)2.60660165
146indolalkylamine catabolic process (GO:0046218)2.60660165
147tryptophan catabolic process (GO:0006569)2.60660165
148regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.60058645
149pteridine-containing compound metabolic process (GO:0042558)2.59952945
150spindle assembly checkpoint (GO:0071173)2.59908880
151RNA modification (GO:0009451)2.59353888
152ribosomal small subunit assembly (GO:0000028)2.58602214
153telomere maintenance via semi-conservative replication (GO:0032201)2.58381344
154regulation of lipoprotein particle clearance (GO:0010984)2.58363871
1554-hydroxyproline metabolic process (GO:0019471)2.58012586
156localization within membrane (GO:0051668)2.56923711
157respiratory chain complex IV assembly (GO:0008535)2.56843333
158proline biosynthetic process (GO:0006561)2.56109721
159mitochondrial fission (GO:0000266)2.55931798
160negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.55850435
161regulation of amyloid precursor protein catabolic process (GO:1902991)2.55458193
162termination of RNA polymerase III transcription (GO:0006386)2.55096663
163transcription elongation from RNA polymerase III promoter (GO:0006385)2.55096663
164regulation of glucokinase activity (GO:0033131)2.55074306
165regulation of hexokinase activity (GO:1903299)2.55074306
166somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.54386237
167isotype switching (GO:0045190)2.54386237
168somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.54386237
169synaptonemal complex assembly (GO:0007130)2.54295616
170negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.52906193
171tRNA methylation (GO:0030488)2.52872505
172regulation of RIG-I signaling pathway (GO:0039535)2.52163135
173rRNA metabolic process (GO:0016072)2.50913218
174L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.49418256
175fucose metabolic process (GO:0006004)2.49198506
176membrane budding (GO:0006900)2.47895809
177meiotic cell cycle process (GO:1903046)2.47353065
178single-organism membrane fusion (GO:0044801)2.47151859
179regulation of mitochondrial translation (GO:0070129)2.46852460
180negative regulation of cell aging (GO:0090344)2.46685419
1817-methylguanosine mRNA capping (GO:0006370)2.45851841
182reciprocal DNA recombination (GO:0035825)2.44745757
183reciprocal meiotic recombination (GO:0007131)2.44745757
184tRNA aminoacylation for protein translation (GO:0006418)2.44608220

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA1_22025678_ChIP-Seq_K562_Human5.46577086
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.05542716
3E2F7_22180533_ChIP-Seq_HELA_Human3.89526367
4* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.78359415
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.68589659
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.40826981
7* GABP_17652178_ChIP-ChIP_JURKAT_Human3.27644942
8* EST1_17652178_ChIP-ChIP_JURKAT_Human3.16647286
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.02560074
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.97068245
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.92464422
12* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.84926845
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.81605055
14EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.81196322
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.75472533
16CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.73136712
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58496534
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.51236316
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.48129061
20* VDR_23849224_ChIP-Seq_CD4+_Human2.43518965
21EGR1_23403033_ChIP-Seq_LIVER_Mouse2.38230180
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.36087129
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.35236640
24AR_21909140_ChIP-Seq_LNCAP_Human2.35056694
25CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.34879855
26XRN2_22483619_ChIP-Seq_HELA_Human2.33207086
27* DCP1A_22483619_ChIP-Seq_HELA_Human2.30933095
28* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.28564239
29E2F1_18555785_ChIP-Seq_MESCs_Mouse2.23426946
30FOXM1_23109430_ChIP-Seq_U2OS_Human2.23331937
31* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18107757
32CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17800823
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.15117199
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12371520
35SRF_21415370_ChIP-Seq_HL-1_Mouse2.12115131
36* FOXP3_21729870_ChIP-Seq_TREG_Human2.11711057
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.05791308
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.05646299
39* GABP_19822575_ChIP-Seq_HepG2_Human2.05526526
40* ELF1_17652178_ChIP-ChIP_JURKAT_Human2.04516899
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.02037076
42VDR_22108803_ChIP-Seq_LS180_Human1.94930780
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.91002790
44* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88509747
45PPARA_22158963_ChIP-Seq_LIVER_Mouse1.81871132
46RXR_22158963_ChIP-Seq_LIVER_Mouse1.81509711
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.80359351
48ZNF263_19887448_ChIP-Seq_K562_Human1.78128243
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.75793696
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.72221456
51TTF2_22483619_ChIP-Seq_HELA_Human1.71932283
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.69213291
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.65367722
54* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.64261886
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.64032745
56* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.56402207
57* NOTCH1_21737748_ChIP-Seq_TLL_Human1.54867569
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54050277
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52843335
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50515885
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.44540216
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38316409
63PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.36196546
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35328746
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.29367440
66ZNF274_21170338_ChIP-Seq_K562_Hela1.26825592
67KDM5A_27292631_Chip-Seq_BREAST_Human1.25051822
68ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24810699
69ELK1_19687146_ChIP-ChIP_HELA_Human1.23770881
70FUS_26573619_Chip-Seq_HEK293_Human1.22422686
71CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20788548
72TAF15_26573619_Chip-Seq_HEK293_Human1.20572785
73CIITA_25753668_ChIP-Seq_RAJI_Human1.19936894
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.19380068
75BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17464784
76TP53_22573176_ChIP-Seq_HFKS_Human1.16745600
77CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.15313187
78* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.14578716
79TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10633879
80GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.10259840
81ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09033715
82RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08852239
83PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.07944027
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07580118
85TFEB_21752829_ChIP-Seq_HELA_Human1.06822715
86HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06602482
87* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.04797416
88* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.03914050
89* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02006714
90MYC_18940864_ChIP-ChIP_HL60_Human1.01634915
91SALL1_21062744_ChIP-ChIP_HESCs_Human1.00259336
92KAP1_22055183_ChIP-Seq_ESCs_Mouse0.99252684
93SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98530428
94KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95156329
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93260307
96POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92662262
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91496862
98CHD1_26751641_Chip-Seq_LNCaP_Human0.91257680
99HIF1A_21447827_ChIP-Seq_MCF-7_Human0.89658283
100LXR_22158963_ChIP-Seq_LIVER_Mouse0.89393466
101GATA4_21415370_ChIP-Seq_HL-1_Mouse0.87863375
102PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.86929083
103ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.86765113
104ELK1_22589737_ChIP-Seq_MCF10A_Human0.85432891
105DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84990458
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82462144
107* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.82447226
108ERG_20517297_ChIP-Seq_VCAP_Human0.80947076
109NANOG_18555785_ChIP-Seq_MESCs_Mouse0.79860627
110* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.79811971
111AR_21572438_ChIP-Seq_LNCaP_Human0.79769758
112GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79581636
113MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.78132386
114POU3F2_20337985_ChIP-ChIP_501MEL_Human0.77663340
115* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.76010860
116CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.75654786
117FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.75347829
118AUTS2_25519132_ChIP-Seq_293T-REX_Human0.75226596
119TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74054630
120* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.73837365
121ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.73827434
122SOX17_20123909_ChIP-Seq_XEN_Mouse0.73218113
123FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.72681086
124PU.1_20513432_ChIP-Seq_Bcells_Mouse0.72229184
125GATA3_26560356_Chip-Seq_TH1_Human0.71362418
126TBX5_21415370_ChIP-Seq_HL-1_Mouse0.70943857
127CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.70308300
128SPI1_23547873_ChIP-Seq_NB4_Human0.70181856
129STAT3_1855785_ChIP-Seq_MESCs_Mouse0.67805330
130* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.64933286
131* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63930700

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis4.84342315
2MP0003806_abnormal_nucleotide_metabolis4.04470755
3MP0003693_abnormal_embryo_hatching3.92556773
4MP0005360_urolithiasis3.84660525
5MP0005365_abnormal_bile_salt3.73972709
6MP0002139_abnormal_hepatobiliary_system3.69093774
7MP0009697_abnormal_copulation3.57328591
8MP0004957_abnormal_blastocyst_morpholog3.47704958
9MP0005171_absent_coat_pigmentation3.18579515
10MP0003303_peritoneal_inflammation3.12362778
11MP0010094_abnormal_chromosome_stability2.96605633
12MP0005085_abnormal_gallbladder_physiolo2.90174255
13MP0008058_abnormal_DNA_repair2.89179021
14MP0003111_abnormal_nucleus_morphology2.86863058
15MP0008875_abnormal_xenobiotic_pharmacok2.74290729
16MP0003077_abnormal_cell_cycle2.41759778
17MP0005423_abnormal_somatic_nervous2.25854878
18MP0005220_abnormal_exocrine_pancreas2.25188134
19MP0003136_yellow_coat_color2.15234947
20MP0000751_myopathy2.11041472
21MP0003186_abnormal_redox_activity2.08402896
22MP0001664_abnormal_digestion1.98820080
23MP0005332_abnormal_amino_acid1.97638637
24MP0003718_maternal_effect1.94062618
25MP0008057_abnormal_DNA_replication1.91856288
26MP0002876_abnormal_thyroid_physiology1.90500003
27MP0001929_abnormal_gametogenesis1.84881568
28MP0008007_abnormal_cellular_replicative1.83781721
29MP0009379_abnormal_foot_pigmentation1.81426841
30MP0003195_calcinosis1.78379893
31MP0005410_abnormal_fertilization1.77291907
32MP0002210_abnormal_sex_determination1.76253380
33MP0002396_abnormal_hematopoietic_system1.73080184
34MP0005174_abnormal_tail_pigmentation1.72114270
35MP0000749_muscle_degeneration1.71621604
36MP0008877_abnormal_DNA_methylation1.69052130
37MP0002751_abnormal_autonomic_nervous1.67429232
38MP0001764_abnormal_homeostasis1.66320993
39MP0003646_muscle_fatigue1.64223222
40MP0003937_abnormal_limbs/digits/tail_de1.63855101
41MP0008789_abnormal_olfactory_epithelium1.63630076
42MP0002638_abnormal_pupillary_reflex1.61716805
43MP0000383_abnormal_hair_follicle1.56872193
44MP0006036_abnormal_mitochondrial_physio1.53580861
45MP0010030_abnormal_orbit_morphology1.49772801
46MP0001145_abnormal_male_reproductive1.49518888
47MP0001529_abnormal_vocalization1.47581780
48MP0000653_abnormal_sex_gland1.45811476
49MP0005623_abnormal_meninges_morphology1.43086639
50MP0005379_endocrine/exocrine_gland_phen1.42537448
51MP0008932_abnormal_embryonic_tissue1.40548551
52MP0010329_abnormal_lipoprotein_level1.40043990
53MP0000015_abnormal_ear_pigmentation1.39003293
54MP0003011_delayed_dark_adaptation1.38381589
55MP0005647_abnormal_sex_gland1.37874807
56MP0005394_taste/olfaction_phenotype1.37425379
57MP0005499_abnormal_olfactory_system1.37425379
58MP0003698_abnormal_male_reproductive1.35546369
59MP0003115_abnormal_respiratory_system1.34715039
60MP0002163_abnormal_gland_morphology1.32597217
61MP0005319_abnormal_enzyme/_coenzyme1.29823508
62MP0005266_abnormal_metabolism1.27646150
63MP0003868_abnormal_feces_composition1.27050125
64MP0001346_abnormal_lacrimal_gland1.26493292
65MP0002132_abnormal_respiratory_system1.25416200
66MP0000609_abnormal_liver_physiology1.24770883
67MP0000467_abnormal_esophagus_morphology1.24157438
68MP0001986_abnormal_taste_sensitivity1.23949277
69MP0005451_abnormal_body_composition1.23839704
70MP0003656_abnormal_erythrocyte_physiolo1.23595881
71MP0000747_muscle_weakness1.22162134
72MP0010678_abnormal_skin_adnexa1.18491476
73MP0001119_abnormal_female_reproductive1.16583536
74MP0003786_premature_aging1.15550161
75MP0000750_abnormal_muscle_regeneration1.15480003
76MP0006072_abnormal_retinal_apoptosis1.13210412
77MP0003890_abnormal_embryonic-extraembry1.12855000
78MP0001730_embryonic_growth_arrest1.08797613
79MP0005083_abnormal_biliary_tract1.08495357
80MP0003763_abnormal_thymus_physiology1.04532573
81MP0001915_intracranial_hemorrhage1.04198588
82MP0006082_CNS_inflammation1.03984869
83MP0000358_abnormal_cell_content/1.02852508
84MP0005330_cardiomyopathy1.01408780
85MP0001666_abnormal_nutrient_absorption1.00908852
86MP0004147_increased_porphyrin_level1.00770956
87MP0003252_abnormal_bile_duct0.99867616
88MP0005636_abnormal_mineral_homeostasis0.99558765
89MP0002269_muscular_atrophy0.98982913
90MP0006035_abnormal_mitochondrial_morpho0.97213395
91MP0000490_abnormal_crypts_of0.96404340
92MP0000759_abnormal_skeletal_muscle0.95624873
93MP0004197_abnormal_fetal_growth/weight/0.94984538
94MP0000534_abnormal_ureter_morphology0.93841350
95MP0001944_abnormal_pancreas_morphology0.93253961
96MP0004043_abnormal_pH_regulation0.92158877
97MP0000598_abnormal_liver_morphology0.91431692
98MP0003221_abnormal_cardiomyocyte_apopto0.90237854
99MP0002161_abnormal_fertility/fecundity0.89766217
100MP0003123_paternal_imprinting0.89461005
101MP0002102_abnormal_ear_morphology0.89248913
102MP0000350_abnormal_cell_proliferation0.86839928
103MP0009643_abnormal_urine_homeostasis0.86195062
104MP0005253_abnormal_eye_physiology0.85595616
105MP0002019_abnormal_tumor_incidence0.85407747
106MP0003453_abnormal_keratinocyte_physiol0.84725344
107MP0001324_abnormal_eye_pigmentation0.83690134
108MP0005501_abnormal_skin_physiology0.81226656
109MP0001502_abnormal_circadian_rhythm0.80715483
110MP0003935_abnormal_craniofacial_develop0.80657993
111MP0004233_abnormal_muscle_weight0.78994384
112MP0000427_abnormal_hair_cycle0.78989278
113MP0001984_abnormal_olfaction0.77847322
114MP0004133_heterotaxia0.77100037
115MP0003137_abnormal_impulse_conducting0.76465039
116MP0001919_abnormal_reproductive_system0.76316331
117MP0000313_abnormal_cell_death0.75816937
118MP0002909_abnormal_adrenal_gland0.75811878
119MP0002118_abnormal_lipid_homeostasis0.75504054
120MP0000470_abnormal_stomach_morphology0.75363519
121MP0001853_heart_inflammation0.74772398
122MP0005389_reproductive_system_phenotype0.73723914
123MP0003699_abnormal_female_reproductive0.73434413
124MP0003943_abnormal_hepatobiliary_system0.73421188
125MP0003984_embryonic_growth_retardation0.72833761
126MP0001661_extended_life_span0.72664360
127MP0004019_abnormal_vitamin_homeostasis0.72613080
128MP0000678_abnormal_parathyroid_gland0.72052855
129MP0009250_abnormal_appendicular_skeleto0.71703707
130MP0004145_abnormal_muscle_electrophysio0.71395080
131MP0005376_homeostasis/metabolism_phenot0.71186580
132MP0009840_abnormal_foam_cell0.70944089
133MP0002088_abnormal_embryonic_growth/wei0.70936355
134MP0002693_abnormal_pancreas_physiology0.70899727
135MP0001697_abnormal_embryo_size0.69370976
136MP0005395_other_phenotype0.68726119
137MP0002080_prenatal_lethality0.68635562
138MP0005197_abnormal_uvea_morphology0.68122964
139MP0001672_abnormal_embryogenesis/_devel0.65693580
140MP0005380_embryogenesis_phenotype0.65693580
141MP0001188_hyperpigmentation0.65648455
142MP0010307_abnormal_tumor_latency0.65627133
143MP0003959_abnormal_lean_body0.65474481
144MP0001293_anophthalmia0.65203727
145MP0009384_cardiac_valve_regurgitation0.65130576
146MP0000689_abnormal_spleen_morphology0.63230477
147MP0009763_increased_sensitivity_to0.63086528
148MP0000579_abnormal_nail_morphology0.62429003
149MP0000703_abnormal_thymus_morphology0.61510981
150MP0002722_abnormal_immune_system0.61312336
151MP0005584_abnormal_enzyme/coenzyme_acti0.59396547
152MP0002160_abnormal_reproductive_system0.58303827

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.48261481
2Osteomalacia (HP:0002749)3.98698404
3Microvesicular hepatic steatosis (HP:0001414)3.80425868
4Testicular atrophy (HP:0000029)3.74457815
5Progressive muscle weakness (HP:0003323)3.68454400
6Hyperglycinemia (HP:0002154)3.65063063
7Large for gestational age (HP:0001520)3.57232202
8Duplicated collecting system (HP:0000081)3.53396605
9Oral leukoplakia (HP:0002745)3.52850829
10Abnormality of renal resorption (HP:0011038)3.47318323
11Hypobetalipoproteinemia (HP:0003563)3.30711872
12Reduced antithrombin III activity (HP:0001976)3.27430975
13Aplastic anemia (HP:0001915)3.20515401
14Rectal fistula (HP:0100590)3.17216412
15Rectovaginal fistula (HP:0000143)3.17216412
16Abnormality of pyrimidine metabolism (HP:0004353)3.08888731
17Vaginal fistula (HP:0004320)3.08797905
18Abnormality of the renal collecting system (HP:0004742)3.01382646
19Anterior segment dysgenesis (HP:0007700)3.01270693
20Irregular epiphyses (HP:0010582)2.99683027
21Lipid accumulation in hepatocytes (HP:0006561)2.95641801
22Abnormal protein glycosylation (HP:0012346)2.94357289
23Abnormal glycosylation (HP:0012345)2.94357289
24Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.94357289
25Abnormal protein N-linked glycosylation (HP:0012347)2.94357289
26Abnormality of serum amino acid levels (HP:0003112)2.91409451
27Long foot (HP:0001833)2.91192266
28Hypoplastic pelvis (HP:0008839)2.90182625
29Type I transferrin isoform profile (HP:0003642)2.89439772
30Myoglobinuria (HP:0002913)2.88066374
31Exercise-induced muscle cramps (HP:0003710)2.87478931
32Prolonged partial thromboplastin time (HP:0003645)2.87279832
33Carpal bone hypoplasia (HP:0001498)2.86632402
34Oligodactyly (hands) (HP:0001180)2.86377722
35Rhabdomyolysis (HP:0003201)2.85159604
36Abnormality of glycolysis (HP:0004366)2.83270374
37Increased serum pyruvate (HP:0003542)2.83270374
38Abnormality of glycine metabolism (HP:0010895)2.80237477
39Abnormality of serine family amino acid metabolism (HP:0010894)2.80237477
40Rough bone trabeculation (HP:0100670)2.79141212
41Hyperglycinuria (HP:0003108)2.75732822
42Abnormality of the anterior horn cell (HP:0006802)2.74283214
43Degeneration of anterior horn cells (HP:0002398)2.74283214
44Cholecystitis (HP:0001082)2.71892440
45Abnormal gallbladder physiology (HP:0012438)2.71892440
46Hepatic necrosis (HP:0002605)2.71234514
47Conjugated hyperbilirubinemia (HP:0002908)2.70598536
48Birth length less than 3rd percentile (HP:0003561)2.70232407
49Colon cancer (HP:0003003)2.70011813
50Hepatocellular necrosis (HP:0001404)2.67993729
51Fetal akinesia sequence (HP:0001989)2.66773529
52Type 2 muscle fiber atrophy (HP:0003554)2.64227706
53Intestinal fistula (HP:0100819)2.62799487
54Increased hepatocellular lipid droplets (HP:0006565)2.61887993
55Abnormality of monocarboxylic acid metabolism (HP:0010996)2.61227784
56Autoamputation (HP:0001218)2.59459217
57Horizontal nystagmus (HP:0000666)2.58186301
58Increased serum lactate (HP:0002151)2.57624063
59Dicarboxylic aciduria (HP:0003215)2.56282651
60Abnormality of dicarboxylic acid metabolism (HP:0010995)2.56282651
61Abnormal urine phosphate concentration (HP:0012599)2.55942328
62Severe muscular hypotonia (HP:0006829)2.54853427
63Abnormality of the intrinsic pathway (HP:0010989)2.54768136
64Intrahepatic cholestasis (HP:0001406)2.51436139
65Hyperammonemia (HP:0001987)2.51424257
66Oligodactyly (HP:0012165)2.50997226
67Muscle fiber atrophy (HP:0100295)2.49673885
68Hypoplasia of the fovea (HP:0007750)2.47435720
69Aplasia/Hypoplasia of the fovea (HP:0008060)2.47435720
70Methylmalonic acidemia (HP:0002912)2.43743324
71Abnormal spermatogenesis (HP:0008669)2.43210339
72Aplasia of the musculature (HP:0100854)2.41948641
73Facial hemangioma (HP:0000329)2.39677722
74Exercise intolerance (HP:0003546)2.37772846
75Cholelithiasis (HP:0001081)2.37685618
76Ketosis (HP:0001946)2.35812869
77Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.33467594
78Lethargy (HP:0001254)2.33214207
79Increased CSF lactate (HP:0002490)2.31972374
80Hypoglycemic coma (HP:0001325)2.31776417
81Reticulocytopenia (HP:0001896)2.28979846
82Aplasia/Hypoplasia of the lens (HP:0008063)2.28772920
83Microretrognathia (HP:0000308)2.25425840
84Abnormality of alanine metabolism (HP:0010916)2.25100416
85Hyperalaninemia (HP:0003348)2.25100416
86Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.25100416
87Amniotic constriction ring (HP:0009775)2.23370787
88Abnormality of placental membranes (HP:0011409)2.23370787
89Abnormal gallbladder morphology (HP:0012437)2.22727702
90Split foot (HP:0001839)2.22019477
91Abnormal ventriculo-arterial connection (HP:0011563)2.20919999
92Transposition of the great arteries (HP:0001669)2.20919999
93Abnormal connection of the cardiac segments (HP:0011545)2.20919999
94Proximal tubulopathy (HP:0000114)2.20807745
95Rhabdomyosarcoma (HP:0002859)2.20611548
96Adactyly (HP:0009776)2.19829541
97Shoulder girdle muscle weakness (HP:0003547)2.19815425
98Hyperlipoproteinemia (HP:0010980)2.16849662
99Hypolipoproteinemia (HP:0010981)2.16589924
100Hyperbilirubinemia (HP:0002904)2.15582289
101Hyperphosphaturia (HP:0003109)2.13978813
102Cerebral edema (HP:0002181)2.13741847
103Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.12884439
104Decreased activity of mitochondrial respiratory chain (HP:0008972)2.12884439
105Abnormality of the fovea (HP:0000493)2.12182142
106Double outlet right ventricle (HP:0001719)2.11888197
107Congenital malformation of the right heart (HP:0011723)2.11888197
108Delayed epiphyseal ossification (HP:0002663)2.11725287
109Abnormal trabecular bone morphology (HP:0100671)2.07277289
110Rib fusion (HP:0000902)2.04546995
111Zonular cataract (HP:0010920)2.04386749
112Abnormality of methionine metabolism (HP:0010901)2.04168386
113Broad nasal tip (HP:0000455)2.03949208
114Hyperglycemia (HP:0003074)2.02866070
115Menstrual irregularities (HP:0000858)2.02562400
116Lip pit (HP:0100267)2.02078958
117Pancytopenia (HP:0001876)2.01178437
118Methylmalonic aciduria (HP:0012120)2.00987317
119Xanthomatosis (HP:0000991)2.00793820
120Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.99609558
121Renal Fanconi syndrome (HP:0001994)1.98334826
122Lactic acidosis (HP:0003128)1.97939240
123Mitochondrial inheritance (HP:0001427)1.97914724
124Respiratory difficulties (HP:0002880)1.97681172
125Increased muscle lipid content (HP:0009058)1.97471433
126Hyperinsulinemic hypoglycemia (HP:0000825)1.97442137
127Abnormality of lateral ventricle (HP:0030047)1.97226031
128* Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.97032043
129CNS demyelination (HP:0007305)1.95999408
130* Abnormality of fatty-acid metabolism (HP:0004359)1.95097767
131Rickets (HP:0002748)1.94910729
132Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.94364565
133Septate vagina (HP:0001153)1.92919250
134Exercise-induced myalgia (HP:0003738)1.92824018
135* Brushfield spots (HP:0001088)1.92166393
136Supernumerary spleens (HP:0009799)1.90241047
137Hypoplastic nipples (HP:0002557)1.90055271
138Renal tubular dysfunction (HP:0000124)1.89948852
139Poor suck (HP:0002033)1.89853975
140Abnormality of aspartate family amino acid metabolism (HP:0010899)1.89843506
141Chromsome breakage (HP:0040012)1.88938762
142Atelectasis (HP:0100750)1.87985525
143Megaloblastic anemia (HP:0001889)1.87760589
144Rimmed vacuoles (HP:0003805)1.86657954
145Azoospermia (HP:0000027)1.86427038
146Small epiphyses (HP:0010585)1.86033609
147Ureteral duplication (HP:0000073)1.86031977
148Abnormal tarsal ossification (HP:0008369)1.85208629
149Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.84594463
150Impulsivity (HP:0100710)1.84188101
151Flat capital femoral epiphysis (HP:0003370)1.83042589
152Popliteal pterygium (HP:0009756)1.82704439
153Aplasia/Hypoplasia involving the musculature (HP:0001460)1.82070578
154Neonatal respiratory distress (HP:0002643)1.81116615
155Generalized aminoaciduria (HP:0002909)1.80249839
156Hypoglycemic seizures (HP:0002173)1.79997859
157Abnormality of the heme biosynthetic pathway (HP:0010472)1.79803623
158Metabolic acidosis (HP:0001942)1.79419179
159Symptomatic seizures (HP:0011145)1.78952760
160Increased intramyocellular lipid droplets (HP:0012240)1.78336947
161Abnormality of the gallbladder (HP:0005264)1.77483425
162Postnatal microcephaly (HP:0005484)1.77154169
163Occipital encephalocele (HP:0002085)1.76324609
164Glycosuria (HP:0003076)1.76221650
165Abnormality of urine glucose concentration (HP:0011016)1.76221650
166Anal atresia (HP:0002023)1.76131295
167Pulmonary artery stenosis (HP:0004415)1.75648367
168Ulnar bowing (HP:0003031)1.75159723
169Squamous cell carcinoma (HP:0002860)1.74732845
170Hypoplastic heart (HP:0001961)1.73830805
171Myotonia (HP:0002486)1.73081986

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.55909465
2TAOK14.09606742
3BCKDK3.93497306
4WEE13.77132089
5PINK13.32870689
6PASK3.21710716
7STK163.11039878
8BRSK22.86737829
9SRPK12.74040805
10FLT32.52721866
11EIF2AK12.47422958
12NME22.39338823
13EIF2AK32.33065538
14PNCK2.32957830
15NLK1.95125858
16NEK21.94177438
17PIM21.91031155
18TAOK31.89829727
19ACVR1B1.89694690
20PDK31.83361584
21PDK41.83361584
22DYRK31.81093999
23PBK1.80131596
24VRK11.73801704
25CDC71.71278766
26MET1.66951006
27PLK11.50409145
28TNIK1.50095675
29OBSCN1.48592784
30CDK121.36810600
31BRSK11.36344004
32MAP3K31.35865343
33BRD41.32886819
34TTK1.32289391
35WNK41.32238724
36ERBB31.29553327
37BRAF1.28870264
38STK38L1.26227036
39MAP3K51.25241571
40CDK71.22979133
41ABL21.16011267
42PLK41.15763089
43TEC1.13478944
44TRIM281.10719540
45NME11.07439120
46INSRR1.04860869
47PLK31.02824371
48ZAP701.01136156
49MAP4K21.00377568
50ATR0.99446298
51STK390.97936362
52ERN10.97062056
53AURKB0.96984277
54MKNK10.95288622
55NEK10.94571761
56MAPK150.94356653
57MAP4K10.94026521
58ZAK0.93501205
59STK380.93404605
60TAOK20.91123041
61IRAK30.91035394
62ERBB40.91004643
63MKNK20.86823898
64RPS6KA40.86343473
65CHEK20.86279732
66NUAK10.85327303
67EIF2AK20.84212191
68TGFBR10.83557646
69PDK20.81393779
70MAPK110.81226918
71MAP2K60.80257575
72NEK90.79202387
73TSSK60.75803654
74MST40.74968036
75STK100.74703212
76IRAK10.73976941
77TESK10.73888008
78DYRK20.73587032
79STK240.73529541
80MELK0.70218873
81NEK60.69258934
82RPS6KB20.68986225
83AURKA0.68433040
84KSR10.67828935
85MAPKAPK30.66843877
86MAP2K70.65998962
87BTK0.64681346
88CHEK10.63669034
89CCNB10.62235162
90PHKG20.60770604
91PHKG10.60770604
92CAMK1G0.60295334
93CDK40.59807708
94MAP2K30.59296130
95MAP3K60.59158434
96DYRK1B0.58385892
97CDK80.58334897
98KIT0.57180896
99IRAK20.56303556
100RAF10.55394208
101TLK10.54329942
102CSNK2A10.53108202
103PRKCI0.52230650
104CDK190.52042966
105IRAK40.50493480
106MAP3K80.49428748
107MAP3K40.48454583
108AKT20.48287622
109CSNK1G10.45947950
110WNK10.45686222
111CSNK2A20.45214153
112LATS10.44543249
113ARAF0.43598997
114FGFR40.43134021
115PLK20.42712843
116KSR20.41879713
117STK30.41389419
118MAP3K110.40465119
119ATM0.40153064
120PTK2B0.39965075
121BMX0.36974602
122CDK30.36276888
123TXK0.35951542
124MST1R0.35572871
125STK40.34900396
126ITK0.33697758
127PIM10.33507166
128MAP3K10.33124709
129WNK30.31921039
130JAK30.30285192
131DYRK1A0.29626455
132CSNK1A10.29477247
133SYK0.29256540
134CDK20.28986255
135MOS0.28917116
136CSNK1G30.27665922
137RPS6KB10.27197025
138BMPR20.25924007
139CDK10.25904394
140CASK0.21491389
141CSNK1E0.20705719
142OXSR10.18915964
143CSNK1A1L0.17710890
144EPHA40.16963091
145CSNK1G20.16101595
146MUSK0.15625110

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.57846364
2Protein export_Homo sapiens_hsa030602.42795347
3RNA polymerase_Homo sapiens_hsa030202.38168424
4Folate biosynthesis_Homo sapiens_hsa007902.37290224
5SNARE interactions in vesicular transport_Homo sapiens_hsa041302.35701430
6Mismatch repair_Homo sapiens_hsa034302.23010207
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.18911899
8DNA replication_Homo sapiens_hsa030302.16078977
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.11485784
10Sulfur relay system_Homo sapiens_hsa041222.10436411
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.09115811
12Cyanoamino acid metabolism_Homo sapiens_hsa004602.08428577
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.07789602
14One carbon pool by folate_Homo sapiens_hsa006702.04866280
15Lysine degradation_Homo sapiens_hsa003102.03031019
16Drug metabolism - other enzymes_Homo sapiens_hsa009831.98863683
17Ribosome_Homo sapiens_hsa030101.96703605
18Proteasome_Homo sapiens_hsa030501.93659362
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.90312507
20Pyrimidine metabolism_Homo sapiens_hsa002401.88269766
21Vitamin B6 metabolism_Homo sapiens_hsa007501.87168613
22Selenocompound metabolism_Homo sapiens_hsa004501.87115045
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.84098460
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.82005577
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.78876187
26Base excision repair_Homo sapiens_hsa034101.74915348
27Propanoate metabolism_Homo sapiens_hsa006401.73766016
28Basal transcription factors_Homo sapiens_hsa030221.73358658
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.72630419
30RNA transport_Homo sapiens_hsa030131.63276919
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.58862587
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.58247186
33Homologous recombination_Homo sapiens_hsa034401.56962769
34Biosynthesis of amino acids_Homo sapiens_hsa012301.55039452
35Fatty acid degradation_Homo sapiens_hsa000711.51598355
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50923606
37Arginine biosynthesis_Homo sapiens_hsa002201.49237782
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.48544722
39Caffeine metabolism_Homo sapiens_hsa002321.47006327
40Cell cycle_Homo sapiens_hsa041101.41804534
41* Peroxisome_Homo sapiens_hsa041461.40028545
42Spliceosome_Homo sapiens_hsa030401.38718228
43Sulfur metabolism_Homo sapiens_hsa009201.35483864
44Circadian rhythm_Homo sapiens_hsa047101.31980396
45Non-homologous end-joining_Homo sapiens_hsa034501.31973292
46Pyruvate metabolism_Homo sapiens_hsa006201.29706477
47Nucleotide excision repair_Homo sapiens_hsa034201.29601556
48Tryptophan metabolism_Homo sapiens_hsa003801.27133072
49Pentose phosphate pathway_Homo sapiens_hsa000301.22371929
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17802574
51Glutathione metabolism_Homo sapiens_hsa004801.17125291
52Carbon metabolism_Homo sapiens_hsa012001.14905272
53Arginine and proline metabolism_Homo sapiens_hsa003301.13671241
54Steroid hormone biosynthesis_Homo sapiens_hsa001401.11888286
55RNA degradation_Homo sapiens_hsa030181.11305596
56Fanconi anemia pathway_Homo sapiens_hsa034601.09309161
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08667433
58Chemical carcinogenesis_Homo sapiens_hsa052041.08377904
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07869806
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06569526
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05461023
62Starch and sucrose metabolism_Homo sapiens_hsa005001.04032618
63Oocyte meiosis_Homo sapiens_hsa041141.03530682
64Retinol metabolism_Homo sapiens_hsa008301.03040727
65Purine metabolism_Homo sapiens_hsa002301.01442569
66Butanoate metabolism_Homo sapiens_hsa006500.98376341
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96280064
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95773099
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95594403
70Fatty acid metabolism_Homo sapiens_hsa012120.92784067
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91356611
72beta-Alanine metabolism_Homo sapiens_hsa004100.91299345
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88532046
74Taste transduction_Homo sapiens_hsa047420.88277310
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86051296
76Nitrogen metabolism_Homo sapiens_hsa009100.85292072
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83745361
78Metabolic pathways_Homo sapiens_hsa011000.77806728
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.70716377
80p53 signaling pathway_Homo sapiens_hsa041150.67977828
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67397799
82Galactose metabolism_Homo sapiens_hsa000520.65599845
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64892315
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64520775
85Phenylalanine metabolism_Homo sapiens_hsa003600.62989702
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62864598
87Fatty acid elongation_Homo sapiens_hsa000620.62226250
88Regulation of autophagy_Homo sapiens_hsa041400.61721849
89Parkinsons disease_Homo sapiens_hsa050120.61606019
90Complement and coagulation cascades_Homo sapiens_hsa046100.60690956
91Fructose and mannose metabolism_Homo sapiens_hsa000510.60051125
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59545237
93N-Glycan biosynthesis_Homo sapiens_hsa005100.58613567
94Tyrosine metabolism_Homo sapiens_hsa003500.57637113
95Histidine metabolism_Homo sapiens_hsa003400.57325617
96Sphingolipid metabolism_Homo sapiens_hsa006000.56312415
97ABC transporters_Homo sapiens_hsa020100.54719715
98Steroid biosynthesis_Homo sapiens_hsa001000.53381057
99Vitamin digestion and absorption_Homo sapiens_hsa049770.51376665
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.50538168
101mRNA surveillance pathway_Homo sapiens_hsa030150.50312228
102PPAR signaling pathway_Homo sapiens_hsa033200.49690130
103AMPK signaling pathway_Homo sapiens_hsa041520.45646585
104Fatty acid biosynthesis_Homo sapiens_hsa000610.38937723
105Primary immunodeficiency_Homo sapiens_hsa053400.38801841
106Epstein-Barr virus infection_Homo sapiens_hsa051690.38277982
107mTOR signaling pathway_Homo sapiens_hsa041500.37825108
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36387811
109Inositol phosphate metabolism_Homo sapiens_hsa005620.35405649
110TGF-beta signaling pathway_Homo sapiens_hsa043500.34960303
111Huntingtons disease_Homo sapiens_hsa050160.32490756
112Glycerolipid metabolism_Homo sapiens_hsa005610.31601007
113Fat digestion and absorption_Homo sapiens_hsa049750.29882708
114Antigen processing and presentation_Homo sapiens_hsa046120.29579640
115Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28563511
116Herpes simplex infection_Homo sapiens_hsa051680.27911785
117Thyroid cancer_Homo sapiens_hsa052160.27158626
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25101452
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23947002
120Oxidative phosphorylation_Homo sapiens_hsa001900.23374201
121Linoleic acid metabolism_Homo sapiens_hsa005910.23302505

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