PEX13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a peroxisomal membrane protein that binds the type 1 peroxisomal targeting signal receptor via a SH3 domain located in the cytoplasm. Mutations and deficiencies in peroxisomal protein importing and peroxisome assembly lead to peroxisomal biogenesis disorders, an example of which is Zellweger syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.53666405
2establishment of protein localization to mitochondrial membrane (GO:0090151)6.43841081
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.43116645
4ATP synthesis coupled proton transport (GO:0015986)6.03262769
5energy coupled proton transport, down electrochemical gradient (GO:0015985)6.03262769
6respiratory electron transport chain (GO:0022904)5.43134048
7regulation of protein kinase A signaling (GO:0010738)5.41683795
8electron transport chain (GO:0022900)5.33205204
9inner mitochondrial membrane organization (GO:0007007)5.08915233
10behavioral response to nicotine (GO:0035095)4.58447810
11dopamine transport (GO:0015872)4.55710074
12chaperone-mediated protein transport (GO:0072321)4.41058332
13neuron cell-cell adhesion (GO:0007158)4.13519084
14keratinocyte development (GO:0003334)4.09880328
15gamma-aminobutyric acid signaling pathway (GO:0007214)4.04914245
16neurotransmitter catabolic process (GO:0042135)4.00606143
17response to histamine (GO:0034776)3.84942964
18GTP biosynthetic process (GO:0006183)3.80822964
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.72125525
20L-phenylalanine catabolic process (GO:0006559)3.72125525
21transmission of nerve impulse (GO:0019226)3.55594224
22tryptophan catabolic process (GO:0006569)3.49483671
23indole-containing compound catabolic process (GO:0042436)3.49483671
24indolalkylamine catabolic process (GO:0046218)3.49483671
25water-soluble vitamin biosynthetic process (GO:0042364)3.48873990
26fatty acid elongation (GO:0030497)3.48515746
27purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.44104839
28intraciliary transport (GO:0042073)3.42491713
29epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.40271083
30protein localization to cilium (GO:0061512)3.40049545
31purine nucleoside triphosphate biosynthetic process (GO:0009145)3.39965616
32transepithelial transport (GO:0070633)3.39925858
33hydrogen ion transmembrane transport (GO:1902600)3.39301853
34pyrimidine nucleobase catabolic process (GO:0006208)3.36988457
35neural tube formation (GO:0001841)3.36259978
36mating behavior (GO:0007617)3.34267198
37ATP biosynthetic process (GO:0006754)3.33613946
38cilium movement (GO:0003341)3.32625171
39dopamine biosynthetic process (GO:0042416)3.32370218
40L-phenylalanine metabolic process (GO:0006558)3.31270061
41erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.31270061
42kynurenine metabolic process (GO:0070189)3.27069619
43vocalization behavior (GO:0071625)3.25167222
44regulation of protein polyubiquitination (GO:1902914)3.24107946
45neuron recognition (GO:0008038)3.23740558
46catecholamine transport (GO:0051937)3.23219373
47positive regulation of synapse assembly (GO:0051965)3.22122150
48regulation of hippo signaling (GO:0035330)3.21720338
49mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.21704142
50mitochondrial respiratory chain complex I assembly (GO:0032981)3.21704142
51NADH dehydrogenase complex assembly (GO:0010257)3.21704142
52succinate metabolic process (GO:0006105)3.16913553
53piRNA metabolic process (GO:0034587)3.14957166
54intracellular protein transmembrane import (GO:0044743)3.14567106
55proton transport (GO:0015992)3.12151372
56L-fucose catabolic process (GO:0042355)3.11929496
57fucose catabolic process (GO:0019317)3.11929496
58L-fucose metabolic process (GO:0042354)3.11929496
59neurotransmitter biosynthetic process (GO:0042136)3.11400711
60hydrogen transport (GO:0006818)3.10919402
61energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.10239661
62ATP hydrolysis coupled proton transport (GO:0015991)3.10239661
63presynaptic membrane assembly (GO:0097105)3.09369268
64protein localization to synapse (GO:0035418)3.08704807
65limb bud formation (GO:0060174)3.08011402
66UTP biosynthetic process (GO:0006228)3.07591911
67protein complex biogenesis (GO:0070271)3.06167591
68RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.03424622
69epithelial cilium movement (GO:0003351)3.02177240
70indolalkylamine metabolic process (GO:0006586)3.00914079
71response to pheromone (GO:0019236)2.96251525
72alkaloid metabolic process (GO:0009820)2.94950714
73tryptophan metabolic process (GO:0006568)2.94046413
74ribonucleoside triphosphate biosynthetic process (GO:0009201)2.92549486
75detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.91167935
76central nervous system myelination (GO:0022010)2.89773113
77axon ensheathment in central nervous system (GO:0032291)2.89773113
78sulfation (GO:0051923)2.89739579
79oxygen transport (GO:0015671)2.89633267
80UTP metabolic process (GO:0046051)2.88922192
81regulation of glutamate secretion (GO:0014048)2.87721395
82neuron remodeling (GO:0016322)2.86954274
83aldehyde catabolic process (GO:0046185)2.86373061
84phenol-containing compound catabolic process (GO:0019336)2.86313551
85cellular ketone body metabolic process (GO:0046950)2.84751771
86cilium organization (GO:0044782)2.83485487
87righting reflex (GO:0060013)2.83290202
88coenzyme catabolic process (GO:0009109)2.82663578
89substantia nigra development (GO:0021762)2.80117217
90presynaptic membrane organization (GO:0097090)2.80056024
91protein neddylation (GO:0045116)2.78359624
92opsonization (GO:0008228)2.78137013
93magnesium ion transport (GO:0015693)2.77257543
94mitochondrial respiratory chain complex assembly (GO:0033108)2.76378710
95glycerophospholipid catabolic process (GO:0046475)2.76272091
96cilium assembly (GO:0042384)2.75937315
97aromatic amino acid family catabolic process (GO:0009074)2.75566105
98nucleoside diphosphate phosphorylation (GO:0006165)2.75292121
99reflex (GO:0060004)2.74717860
100synaptic vesicle exocytosis (GO:0016079)2.72225767
101regulation of hexokinase activity (GO:1903299)2.68535381
102regulation of glucokinase activity (GO:0033131)2.68535381
103opioid receptor signaling pathway (GO:0038003)2.65966393
104glutamate receptor signaling pathway (GO:0007215)2.65198747
105branched-chain amino acid catabolic process (GO:0009083)2.64057789
106cilium or flagellum-dependent cell motility (GO:0001539)2.63776015
107L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.63654072
108seminiferous tubule development (GO:0072520)2.63362071
109somite development (GO:0061053)2.63305686
110negative regulation of oligodendrocyte differentiation (GO:0048715)2.62241844
111intracellular protein transmembrane transport (GO:0065002)2.62182330
112nonmotile primary cilium assembly (GO:0035058)2.62005579
113somite rostral/caudal axis specification (GO:0032525)2.59921663
114regulation of short-term neuronal synaptic plasticity (GO:0048172)2.59254599
115regulation of dopamine metabolic process (GO:0042053)2.58679269
116regulation of catecholamine metabolic process (GO:0042069)2.58679269
117tyrosine metabolic process (GO:0006570)2.58289564
118regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.58256852
119axonemal dynein complex assembly (GO:0070286)2.57970392
120exogenous drug catabolic process (GO:0042738)2.57347776
121neurotransmitter metabolic process (GO:0042133)2.56387739
122regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.56105143
123nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.55715935
124cilium morphogenesis (GO:0060271)2.55356689
125neuron fate determination (GO:0048664)2.55280105
126nucleobase catabolic process (GO:0046113)2.55221839
127protein polyglutamylation (GO:0018095)2.54959751
128exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.54202968
129drug catabolic process (GO:0042737)2.53701743
130gamma-aminobutyric acid transport (GO:0015812)2.53699256
131positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.52515769
132long-chain fatty acid biosynthetic process (GO:0042759)2.51775348
133female mating behavior (GO:0060180)2.51205652
134cysteine metabolic process (GO:0006534)2.51117099
135regulation of vesicle fusion (GO:0031338)2.50890568
136ubiquinone metabolic process (GO:0006743)2.50682913
137L-methionine salvage (GO:0071267)2.50366070
138L-methionine biosynthetic process (GO:0071265)2.50366070
139amino acid salvage (GO:0043102)2.50366070
140platelet dense granule organization (GO:0060155)2.50177675
141ketone body metabolic process (GO:1902224)2.49976720
142bile acid biosynthetic process (GO:0006699)2.48400716
143nucleoside triphosphate biosynthetic process (GO:0009142)2.47962155
144male meiosis I (GO:0007141)2.47953892
145detection of calcium ion (GO:0005513)2.47203630
146synaptic transmission, cholinergic (GO:0007271)2.46786338
147neurotransmitter transport (GO:0006836)2.45933631
148DNA double-strand break processing (GO:0000729)2.44730407
149maternal behavior (GO:0042711)2.42881391
150ubiquinone biosynthetic process (GO:0006744)2.42149294
151ionotropic glutamate receptor signaling pathway (GO:0035235)2.42037219
152regulation of mesoderm development (GO:2000380)2.41921508
153negative regulation of transcription regulatory region DNA binding (GO:2000678)2.41218969
154regulation of neurotransmitter levels (GO:0001505)2.41166547
155CTP metabolic process (GO:0046036)2.41121773
156signal peptide processing (GO:0006465)2.40281519
157centrosome localization (GO:0051642)2.38088194
158oxidative demethylation (GO:0070989)2.36543832
159cardiac right ventricle morphogenesis (GO:0003215)2.36354765
160GPI anchor metabolic process (GO:0006505)2.33431237
161calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.32766380
162hindbrain development (GO:0030902)2.32309881
163positive regulation of prostaglandin secretion (GO:0032308)2.32245356
164benzene-containing compound metabolic process (GO:0042537)2.30581896
165regulation of gene silencing by RNA (GO:0060966)2.30449679
166regulation of posttranscriptional gene silencing (GO:0060147)2.30449679
167regulation of gene silencing by miRNA (GO:0060964)2.30449679
168S-adenosylmethionine metabolic process (GO:0046500)2.30151181
169gene silencing by RNA (GO:0031047)2.29465462
170proteasome assembly (GO:0043248)2.28589773
171preassembly of GPI anchor in ER membrane (GO:0016254)2.26740603
172indole-containing compound metabolic process (GO:0042430)2.26732225
173isoprenoid biosynthetic process (GO:0008299)2.26584337
174nephron epithelium morphogenesis (GO:0072088)2.26044195
175nephron tubule morphogenesis (GO:0072078)2.26044195
176methionine biosynthetic process (GO:0009086)2.26010451
177negative regulation of translation, ncRNA-mediated (GO:0040033)2.24337383
178regulation of translation, ncRNA-mediated (GO:0045974)2.24337383
179negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.24337383
180regulation of meiosis I (GO:0060631)2.23545238
181prenylation (GO:0097354)2.21825351
182protein prenylation (GO:0018342)2.21825351
183embryonic epithelial tube formation (GO:0001838)2.21468775
184kidney morphogenesis (GO:0060993)2.21121706

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.19836990
2TAF15_26573619_Chip-Seq_HEK293_Human3.77681479
3GBX2_23144817_ChIP-Seq_PC3_Human2.97202677
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.48391685
5CTBP2_25329375_ChIP-Seq_LNCAP_Human2.47515184
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.45843487
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36824171
8CTBP1_25329375_ChIP-Seq_LNCAP_Human2.35034794
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.33999476
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.31466804
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.27857316
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.25441243
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.23047326
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.15453341
15FUS_26573619_Chip-Seq_HEK293_Human2.14714194
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.12850703
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.08066663
18VDR_22108803_ChIP-Seq_LS180_Human2.06654516
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.05568037
20IGF1R_20145208_ChIP-Seq_DFB_Human2.04998749
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04532550
22P300_19829295_ChIP-Seq_ESCs_Human1.94091326
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.93241710
24REST_21632747_ChIP-Seq_MESCs_Mouse1.92869460
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.90688847
26EZH2_27304074_Chip-Seq_ESCs_Mouse1.88957169
27MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85448270
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.81169961
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.80607202
30ER_23166858_ChIP-Seq_MCF-7_Human1.79651993
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.79136276
32EZH2_18974828_ChIP-Seq_MESCs_Mouse1.79136276
33* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.79106083
34SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.77374958
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.75455270
36GABP_17652178_ChIP-ChIP_JURKAT_Human1.75040204
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.73844871
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.71973723
39UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.70322305
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.69234387
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67758933
42ELK1_19687146_ChIP-ChIP_HELA_Human1.67284679
43SMAD4_21799915_ChIP-Seq_A2780_Human1.66287467
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65611856
45SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64580809
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.62119776
47ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.57311881
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.56974110
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54324948
50RNF2_27304074_Chip-Seq_NSC_Mouse1.51630826
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51338516
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.48265731
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.47777587
54AR_21572438_ChIP-Seq_LNCaP_Human1.46607822
55EZH2_27294783_Chip-Seq_ESCs_Mouse1.46469790
56HTT_18923047_ChIP-ChIP_STHdh_Human1.45747288
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45122433
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45004567
59REST_18959480_ChIP-ChIP_MESCs_Mouse1.44688199
60ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.43829853
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39356222
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.37607201
63CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.35068230
64SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34798466
65ZNF274_21170338_ChIP-Seq_K562_Hela1.34196959
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.32013201
67MYC_18940864_ChIP-ChIP_HL60_Human1.31502734
68RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.30694409
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30014147
70IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28101737
71NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27820646
72NOTCH1_21737748_ChIP-Seq_TLL_Human1.27243673
73AR_25329375_ChIP-Seq_VCAP_Human1.26506989
74TCF4_22108803_ChIP-Seq_LS180_Human1.25801309
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25705956
76BCAT_22108803_ChIP-Seq_LS180_Human1.24747741
77JUN_21703547_ChIP-Seq_K562_Human1.24226203
78* EST1_17652178_ChIP-ChIP_JURKAT_Human1.23642376
79EWS_26573619_Chip-Seq_HEK293_Human1.23547768
80* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22729203
81RUNX2_22187159_ChIP-Seq_PCA_Human1.22617107
82RNF2_27304074_Chip-Seq_ESCs_Mouse1.22557117
83EGR1_23403033_ChIP-Seq_LIVER_Mouse1.22554136
84PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22296086
85FLI1_27457419_Chip-Seq_LIVER_Mouse1.21973554
86KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21464105
87TAL1_26923725_Chip-Seq_HPCs_Mouse1.18414908
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.17956651
89NRF2_20460467_ChIP-Seq_MEFs_Mouse1.16376214
90NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.16376214
91FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.15632082
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15517337
93FOXM1_26456572_ChIP-Seq_MCF-7_Human1.15222300
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15165055
95CDX2_22108803_ChIP-Seq_LS180_Human1.14842941
96MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14198357
97PCGF2_27294783_Chip-Seq_ESCs_Mouse1.13559326
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12338229
99RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12222589
100CRX_20693478_ChIP-Seq_RETINA_Mouse1.12194588
101* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11758306
102PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11534008
103KDM2B_26808549_Chip-Seq_REH_Human1.11467308
104P53_22387025_ChIP-Seq_ESCs_Mouse1.11386502
105CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11200040
106* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10509661
107SOX2_21211035_ChIP-Seq_LN229_Gbm1.09779762
108SMAD4_21741376_ChIP-Seq_EPCs_Human1.09653235
109NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.09294400
110TP53_22573176_ChIP-Seq_HFKS_Human1.08755043
111CBP_20019798_ChIP-Seq_JUKART_Human1.08182065
112IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08182065
113ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07581203
114* FLI1_21867929_ChIP-Seq_TH2_Mouse1.07059012
115* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07053103
116RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05987392
117IRF1_19129219_ChIP-ChIP_H3396_Human1.04787479
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04651144
119* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04470033
120CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03763518
121E2F1_18555785_Chip-Seq_ESCs_Mouse1.02812059
122PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.02798226
123STAT3_18555785_Chip-Seq_ESCs_Mouse1.02754956
124FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02342353
125VDR_23849224_ChIP-Seq_CD4+_Human1.01331404
126CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01088867
127FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01018280
128FOXA1_25329375_ChIP-Seq_VCAP_Human1.01018280
129SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00099509
130TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99127786
131TCF4_23295773_ChIP-Seq_U87_Human0.98793018
132KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98782121
133* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98578221
134CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98518607
135* STAT3_23295773_ChIP-Seq_U87_Human0.97509157
136SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97249081
137GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96505176
138CMYC_18555785_Chip-Seq_ESCs_Mouse0.95743458
139NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95658636
140SOX2_19829295_ChIP-Seq_ESCs_Human0.95638927
141NANOG_19829295_ChIP-Seq_ESCs_Human0.95638927

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.82286852
2MP0001529_abnormal_vocalization4.24560896
3MP0006276_abnormal_autonomic_nervous3.72871443
4MP0009046_muscle_twitch2.87779943
5MP0001440_abnormal_grooming_behavior2.77780765
6MP0002139_abnormal_hepatobiliary_system2.76946588
7MP0009745_abnormal_behavioral_response2.76711470
8MP0002837_dystrophic_cardiac_calcinosis2.58515683
9MP0001968_abnormal_touch/_nociception2.58202062
10MP0002064_seizures2.58105582
11MP0003635_abnormal_synaptic_transmissio2.54063839
12MP0003890_abnormal_embryonic-extraembry2.45528412
13MP0002736_abnormal_nociception_after2.45349988
14MP0005360_urolithiasis2.42715639
15MP0001905_abnormal_dopamine_level2.41974755
16MP0001501_abnormal_sleep_pattern2.35979729
17MP0008877_abnormal_DNA_methylation2.31421580
18MP0002572_abnormal_emotion/affect_behav2.18980354
19MP0008875_abnormal_xenobiotic_pharmacok2.14671910
20MP0000427_abnormal_hair_cycle2.12904907
21MP0002272_abnormal_nervous_system2.11695215
22MP0004924_abnormal_behavior2.07281429
23MP0005386_behavior/neurological_phenoty2.07281429
24MP0000383_abnormal_hair_follicle2.05776170
25MP0008789_abnormal_olfactory_epithelium2.05602636
26MP0005187_abnormal_penis_morphology2.00247991
27MP0002063_abnormal_learning/memory/cond1.96220222
28MP0002822_catalepsy1.94692745
29MP0000647_abnormal_sebaceous_gland1.94499013
30MP0003329_amyloid_beta_deposits1.94284926
31MP0003122_maternal_imprinting1.92339644
32MP0005085_abnormal_gallbladder_physiolo1.90491169
33MP0004859_abnormal_synaptic_plasticity1.86267202
34MP0002734_abnormal_mechanical_nocicepti1.84778800
35MP0001486_abnormal_startle_reflex1.84260541
36MP0004133_heterotaxia1.82067514
37MP0000569_abnormal_digit_pigmentation1.79076329
38MP0002876_abnormal_thyroid_physiology1.74409640
39MP0003718_maternal_effect1.74214926
40MP0002067_abnormal_sensory_capabilities1.71093209
41MP0004270_analgesia1.69172715
42MP0005379_endocrine/exocrine_gland_phen1.68854330
43MP0010678_abnormal_skin_adnexa1.64614114
44MP0002938_white_spotting1.64141532
45MP0003937_abnormal_limbs/digits/tail_de1.62925573
46MP0001984_abnormal_olfaction1.61775289
47MP0005423_abnormal_somatic_nervous1.60762389
48MP0005499_abnormal_olfactory_system1.59093491
49MP0005394_taste/olfaction_phenotype1.59093491
50MP0002733_abnormal_thermal_nociception1.58572050
51MP0005365_abnormal_bile_salt1.58477786
52MP0005410_abnormal_fertilization1.57401958
53MP0002234_abnormal_pharynx_morphology1.56609085
54MP0010386_abnormal_urinary_bladder1.55746888
55MP0001970_abnormal_pain_threshold1.54560235
56* MP0004142_abnormal_muscle_tone1.53688801
57MP0005084_abnormal_gallbladder_morpholo1.52725188
58MP0004147_increased_porphyrin_level1.47030991
59MP0001293_anophthalmia1.45445947
60MP0005535_abnormal_body_temperature1.45080136
61MP0003119_abnormal_digestive_system1.43953835
62MP0003136_yellow_coat_color1.41837193
63MP0005646_abnormal_pituitary_gland1.41531925
64MP0002735_abnormal_chemical_nociception1.41244723
65MP0003252_abnormal_bile_duct1.41207576
66MP0003567_abnormal_fetal_cardiomyocyte1.40991693
67MP0005551_abnormal_eye_electrophysiolog1.40895424
68MP0008872_abnormal_physiological_respon1.37986513
69MP0009379_abnormal_foot_pigmentation1.37975245
70MP0002751_abnormal_autonomic_nervous1.36990946
71MP0001502_abnormal_circadian_rhythm1.36589547
72MP0002557_abnormal_social/conspecific_i1.35039821
73MP0004215_abnormal_myocardial_fiber1.33774174
74MP0008058_abnormal_DNA_repair1.31243362
75MP0006072_abnormal_retinal_apoptosis1.30709529
76MP0003690_abnormal_glial_cell1.30191693
77MP0001324_abnormal_eye_pigmentation1.28303297
78MP0000778_abnormal_nervous_system1.28048997
79MP0002102_abnormal_ear_morphology1.27308864
80MP0000049_abnormal_middle_ear1.26731861
81MP0002928_abnormal_bile_duct1.24200886
82MP0002233_abnormal_nose_morphology1.24036136
83MP0002160_abnormal_reproductive_system1.22735554
84MP0002184_abnormal_innervation1.22638757
85MP0005645_abnormal_hypothalamus_physiol1.21377692
86MP0000604_amyloidosis1.19958927
87MP0006036_abnormal_mitochondrial_physio1.19578393
88MP0001666_abnormal_nutrient_absorption1.18836917
89MP0001286_abnormal_eye_development1.17505782
90MP0005332_abnormal_amino_acid1.16890225
91MP0001188_hyperpigmentation1.16406685
92MP0004043_abnormal_pH_regulation1.13119952
93MP0002638_abnormal_pupillary_reflex1.13041820
94MP0005195_abnormal_posterior_eye1.12968855
95MP0002332_abnormal_exercise_endurance1.12101189
96MP0006292_abnormal_olfactory_placode1.10899628
97MP0005377_hearing/vestibular/ear_phenot1.10756668
98MP0003878_abnormal_ear_physiology1.10756668
99MP0001485_abnormal_pinna_reflex1.10747266
100MP0004885_abnormal_endolymph1.10195314
101MP0002282_abnormal_trachea_morphology1.09797715
102MP0005083_abnormal_biliary_tract1.08430145
103MP0004742_abnormal_vestibular_system1.07895367
104MP0002090_abnormal_vision1.07791587
105MP0008995_early_reproductive_senescence1.07452854
106MP0003283_abnormal_digestive_organ1.07184752
107* MP0002066_abnormal_motor_capabilities/c1.06315250
108MP0010329_abnormal_lipoprotein_level1.05345073
109MP0001727_abnormal_embryo_implantation1.03030186
110MP0002653_abnormal_ependyma_morphology1.02903449
111MP0002971_abnormal_brown_adipose1.00503634
112MP0000751_myopathy1.00287720
113MP0000013_abnormal_adipose_tissue0.97498392
114MP0002098_abnormal_vibrissa_morphology0.97073929
115MP0001986_abnormal_taste_sensitivity0.96630064
116MP0005389_reproductive_system_phenotype0.94892876
117MP0003755_abnormal_palate_morphology0.93606690
118MP0010030_abnormal_orbit_morphology0.93521899
119MP0000538_abnormal_urinary_bladder0.93063245
120MP0002095_abnormal_skin_pigmentation0.93052388
121MP0009384_cardiac_valve_regurgitation0.91859037
122MP0004145_abnormal_muscle_electrophysio0.91709064
123* MP0006035_abnormal_mitochondrial_morpho0.91202349
124MP0005409_darkened_coat_color0.91079267
125MP0000920_abnormal_myelination0.89919156
126MP0005408_hypopigmentation0.89882341
127MP0005391_vision/eye_phenotype0.88993400
128MP0000026_abnormal_inner_ear0.87136929
129MP0002909_abnormal_adrenal_gland0.85315913
130MP0002163_abnormal_gland_morphology0.84585208
131* MP0002229_neurodegeneration0.84262490
132* MP0002882_abnormal_neuron_morphology0.84255796
133MP0003941_abnormal_skin_development0.81660040
134MP0002697_abnormal_eye_size0.79781346
135MP0005248_abnormal_Harderian_gland0.79283885
136MP0005670_abnormal_white_adipose0.78728625
137MP0000747_muscle_weakness0.78696924
138MP0000631_abnormal_neuroendocrine_gland0.78330231
139MP0001963_abnormal_hearing_physiology0.77894048
140MP0001764_abnormal_homeostasis0.77809092
141MP0002118_abnormal_lipid_homeostasis0.76722707
142MP0000955_abnormal_spinal_cord0.76221843
143MP0001919_abnormal_reproductive_system0.75920013
144MP0003121_genomic_imprinting0.75224515
145MP0002752_abnormal_somatic_nervous0.73734399
146* MP0002069_abnormal_eating/drinking_beha0.72956438
147MP0003633_abnormal_nervous_system0.72278997
148MP0003646_muscle_fatigue0.71381248
149MP0008874_decreased_physiological_sensi0.70331231
150MP0001664_abnormal_digestion0.70262785
151MP0003634_abnormal_glial_cell0.69095531
152MP0005376_homeostasis/metabolism_phenot0.68930462
153MP0003631_nervous_system_phenotype0.68651496
154* MP0002152_abnormal_brain_morphology0.65979086
155MP0005253_abnormal_eye_physiology0.65744482
156MP0004130_abnormal_muscle_cell0.65449290
157MP0003195_calcinosis0.64839396
158MP0003698_abnormal_male_reproductive0.64167519
159MP0005584_abnormal_enzyme/coenzyme_acti0.62947989

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.24686448
2Abnormal mitochondria in muscle tissue (HP:0008316)4.73291506
3Acute encephalopathy (HP:0006846)4.71020175
4Progressive macrocephaly (HP:0004481)4.65515284
5Abnormal ciliary motility (HP:0012262)4.34399967
6Mitochondrial inheritance (HP:0001427)4.33874420
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.15298677
8Focal motor seizures (HP:0011153)4.08312489
9Abnormal respiratory motile cilium physiology (HP:0012261)4.02284053
10Cerebral edema (HP:0002181)3.92302774
11Dynein arm defect of respiratory motile cilia (HP:0012255)3.89995993
12Absent/shortened dynein arms (HP:0200106)3.89995993
13Abnormality of alanine metabolism (HP:0010916)3.86707173
14Hyperalaninemia (HP:0003348)3.86707173
15Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.86707173
16Type II lissencephaly (HP:0007260)3.79121008
17Pancreatic cysts (HP:0001737)3.75638246
18Increased CSF lactate (HP:0002490)3.66578729
19Abnormal respiratory epithelium morphology (HP:0012253)3.59866566
20Abnormal respiratory motile cilium morphology (HP:0005938)3.59866566
21Neurofibrillary tangles (HP:0002185)3.50002039
22Hepatocellular necrosis (HP:0001404)3.48078162
23True hermaphroditism (HP:0010459)3.45738554
24Increased hepatocellular lipid droplets (HP:0006565)3.38659063
25Pancreatic fibrosis (HP:0100732)3.28099665
26Lipid accumulation in hepatocytes (HP:0006561)3.22886256
27Chronic hepatic failure (HP:0100626)3.20282044
28Cerebellar dysplasia (HP:0007033)3.18110062
29Cerebral inclusion bodies (HP:0100314)3.15771805
30Renal Fanconi syndrome (HP:0001994)3.07977007
31Atonic seizures (HP:0010819)3.06997151
32Optic disc pallor (HP:0000543)3.06253006
33Aplasia/Hypoplasia of the tibia (HP:0005772)3.05292470
34Abnormality of the renal medulla (HP:0100957)3.01398760
35Abnormality of aromatic amino acid family metabolism (HP:0004338)3.01184553
36Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.99771053
37Degeneration of the lateral corticospinal tracts (HP:0002314)2.99771053
38Rhinitis (HP:0012384)2.92786989
39Hepatic necrosis (HP:0002605)2.90776313
40Polyphagia (HP:0002591)2.88943602
41Leukodystrophy (HP:0002415)2.84747390
42Abnormality of the renal cortex (HP:0011035)2.82401412
43Limb dystonia (HP:0002451)2.77823957
44Absence seizures (HP:0002121)2.75789873
45Short tibia (HP:0005736)2.72070939
46Gait imbalance (HP:0002141)2.69710860
47Cerebral hemorrhage (HP:0001342)2.69008918
48Hypothermia (HP:0002045)2.68430575
49Focal seizures (HP:0007359)2.64393592
50Increased intramyocellular lipid droplets (HP:0012240)2.64058426
51Visual hallucinations (HP:0002367)2.63258340
52Hyperglycinemia (HP:0002154)2.59675615
53Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.59516668
54Congenital primary aphakia (HP:0007707)2.53747109
55Lactic acidosis (HP:0003128)2.53458573
56Medial flaring of the eyebrow (HP:0010747)2.53369457
57Myokymia (HP:0002411)2.51246295
58Generalized tonic-clonic seizures (HP:0002069)2.49888596
59Hyperventilation (HP:0002883)2.48934138
60Abnormality of the corticospinal tract (HP:0002492)2.47488259
61Increased muscle lipid content (HP:0009058)2.47180453
62Abnormal pupillary function (HP:0007686)2.46049770
63Hypobetalipoproteinemia (HP:0003563)2.44566248
64Renal cortical cysts (HP:0000803)2.44415749
65Dialeptic seizures (HP:0011146)2.40916978
66Respiratory failure (HP:0002878)2.39613939
67Supernumerary spleens (HP:0009799)2.36184524
68Exercise intolerance (HP:0003546)2.35139204
69* Lissencephaly (HP:0001339)2.34351897
70Congenital stationary night blindness (HP:0007642)2.33238789
71Abnormality of serum amino acid levels (HP:0003112)2.32825804
72Hyperlipoproteinemia (HP:0010980)2.32162933
73Abnormal biliary tract physiology (HP:0012439)2.30645916
74Bile duct proliferation (HP:0001408)2.30645916
75Sensory axonal neuropathy (HP:0003390)2.30058404
76Hyperglycinuria (HP:0003108)2.28969302
77Retinal dysplasia (HP:0007973)2.27402690
78Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.27226184
79Oligomenorrhea (HP:0000876)2.27208215
80Disproportionate short-trunk short stature (HP:0003521)2.26850461
81Sclerocornea (HP:0000647)2.25203912
82Genital tract atresia (HP:0001827)2.25017776
83Deep venous thrombosis (HP:0002625)2.23892755
84Abnormality of the pons (HP:0007361)2.23725838
85Abnormality of the labia minora (HP:0012880)2.22776910
86Rimmed vacuoles (HP:0003805)2.22300277
87Aplasia/Hypoplasia of the tongue (HP:0010295)2.21257311
88Intrahepatic cholestasis (HP:0001406)2.20893296
89Nephrogenic diabetes insipidus (HP:0009806)2.20888227
90Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.20142655
91Abnormality of glycolysis (HP:0004366)2.18891952
92Increased serum pyruvate (HP:0003542)2.18891952
93Prolonged partial thromboplastin time (HP:0003645)2.18395379
94Vaginal atresia (HP:0000148)2.18287208
95Progressive inability to walk (HP:0002505)2.17955119
96X-linked dominant inheritance (HP:0001423)2.17215827
97Lethargy (HP:0001254)2.17177461
98Hyperthyroidism (HP:0000836)2.15119392
99Progressive cerebellar ataxia (HP:0002073)2.15009430
100Chorioretinal atrophy (HP:0000533)2.13668660
101Abnormality of renal resorption (HP:0011038)2.08176020
102Fair hair (HP:0002286)2.08133214
103Parakeratosis (HP:0001036)2.07725071
104Anophthalmia (HP:0000528)2.07101831
105Labial hypoplasia (HP:0000066)2.06314656
106Abnormality of glycine metabolism (HP:0010895)2.03530376
107Abnormality of serine family amino acid metabolism (HP:0010894)2.03530376
108Cholecystitis (HP:0001082)2.02584244
109Abnormal gallbladder physiology (HP:0012438)2.02584244
110Pheochromocytoma (HP:0002666)2.02376220
111Hypoplasia of the pons (HP:0012110)2.02031247
112Insidious onset (HP:0003587)2.01857191
113Termporal pattern (HP:0011008)2.01857191
114Large for gestational age (HP:0001520)2.00836313
115Methylmalonic acidemia (HP:0002912)2.00742703
116Esotropia (HP:0000565)1.99424230
117Aplasia/hypoplasia of the uterus (HP:0008684)1.99113170
118Nephronophthisis (HP:0000090)1.98285213
119Hypoplastic labia majora (HP:0000059)1.98253346
120Increased corneal curvature (HP:0100692)1.97258942
121Keratoconus (HP:0000563)1.97258942
122Abnormal eating behavior (HP:0100738)1.96491545
123Delayed gross motor development (HP:0002194)1.95898652
124Molar tooth sign on MRI (HP:0002419)1.94334982
125Abnormality of midbrain morphology (HP:0002418)1.94334982
126Abolished electroretinogram (ERG) (HP:0000550)1.94000176
127Tubular atrophy (HP:0000092)1.93720914
128Furrowed tongue (HP:0000221)1.93452656
129Neuroendocrine neoplasm (HP:0100634)1.93108882
130Generalized myoclonic seizures (HP:0002123)1.92886404
131Patellar aplasia (HP:0006443)1.92465722
132Male pseudohermaphroditism (HP:0000037)1.91583017
133Cystic liver disease (HP:0006706)1.91395155
134Xanthomatosis (HP:0000991)1.90413025
135Epileptic encephalopathy (HP:0200134)1.90412700
136Pendular nystagmus (HP:0012043)1.89283788
137Aplasia/Hypoplasia of the fibula (HP:0006492)1.88236174
138Fibular hypoplasia (HP:0003038)1.88009567
139Hypoplastic female external genitalia (HP:0012815)1.87740696
140Anxiety (HP:0000739)1.87686668
141Hypoplasia of the uterus (HP:0000013)1.86945223
142Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86733694
143Scrotal hypoplasia (HP:0000046)1.85925648
144Delusions (HP:0000746)1.85876691
145Colon cancer (HP:0003003)1.85622496
146Ketosis (HP:0001946)1.85113459
147Febrile seizures (HP:0002373)1.84177487
148Decreased activity of mitochondrial respiratory chain (HP:0008972)1.84010711
149Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.84010711
150Attenuation of retinal blood vessels (HP:0007843)1.83951114
151Aplasia/Hypoplasia of the uvula (HP:0010293)1.83889585
152Broad-based gait (HP:0002136)1.83744243
153Abnormality of the axillary hair (HP:0100134)1.82759022
154Abnormality of secondary sexual hair (HP:0009888)1.82759022
155Poor suck (HP:0002033)1.82654827
156Abnormality of the labia majora (HP:0012881)1.80899235
157Dysmetria (HP:0001310)1.80686021
158Muscle hypertrophy of the lower extremities (HP:0008968)1.80187734
159Psychosis (HP:0000709)1.79611422
160Optic nerve hypoplasia (HP:0000609)1.79106338
161Birth length less than 3rd percentile (HP:0003561)1.78915037
162Inability to walk (HP:0002540)1.78802052
163Abnormality of macular pigmentation (HP:0008002)1.78726496
164Aplasia/Hypoplasia of the patella (HP:0006498)1.78536591
165Anencephaly (HP:0002323)1.76125808
166Thyroid-stimulating hormone excess (HP:0002925)1.75056575
167Glycosuria (HP:0003076)1.75047770
168Abnormality of urine glucose concentration (HP:0011016)1.75047770
169Genetic anticipation (HP:0003743)1.73408007
170Postaxial foot polydactyly (HP:0001830)1.73263639
171Congenital hepatic fibrosis (HP:0002612)1.69254538
172Abnormality of the ileum (HP:0001549)1.68715473
173Concave nail (HP:0001598)1.68544230
174Meckel diverticulum (HP:0002245)1.67033302
175Postaxial hand polydactyly (HP:0001162)1.66946328

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK4.32665832
2MAP3K123.75935627
3FRK3.56012628
4ARAF3.05884673
5ACVR1B2.82077964
6CASK2.69441815
7MAP3K42.60279438
8TNIK2.59251224
9ZAK2.51022265
10MAP3K92.50712875
11MAP4K22.43810220
12STK38L2.37215620
13MAP2K42.32884682
14STK392.25185231
15NTRK32.23445070
16GRK72.14677813
17MAP2K72.08902959
18EPHA42.00974931
19INSRR1.97544902
20MAP3K131.96976039
21TRIM281.96322493
22BRSK21.88099701
23OXSR11.87802743
24MAPKAPK51.76995841
25NTRK11.74031941
26ERBB31.70276103
27GRK11.68459129
28CSNK1G31.62645664
29TSSK61.60850281
30MINK11.60617055
31FES1.59571693
32MKNK21.56989028
33NME11.56795062
34MARK11.53568981
35NUAK11.51070433
36BCR1.48052904
37SRPK11.47183041
38CSNK1G21.44614461
39ADRBK21.42014934
40GRK51.41615533
41NTRK21.40159662
42TLK11.37483444
43MOS1.37026470
44CAMK2A1.33464582
45TGFBR11.33271794
46WEE11.31709689
47FGR1.28828655
48TNK21.27227427
49STK241.24701997
50ERBB41.23623416
51MUSK1.22810705
52CSNK1G11.22694613
53PIK3CA1.20936507
54PDK41.19263325
55PDK31.19263325
56PLK41.16640622
57EIF2AK31.15758826
58MAP3K61.14977145
59BMPR1B1.13718969
60FER1.11983297
61MAPK131.11548378
62WNK41.09556881
63CAMK2B1.08754833
64MAPK151.07253792
65CAMK2D1.06769001
66LATS21.06599205
67MKNK11.05895555
68KSR21.04178720
69CAMK1G1.04053889
70BMPR21.03425382
71BRAF1.03393517
72PLK21.01841221
73STK31.01117016
74MST40.98654337
75IRAK10.98256894
76ADRBK10.96156011
77EPHA30.95220969
78MET0.93410064
79MYLK0.92914268
80PAK30.92902134
81CSNK1A1L0.91692733
82CAMK2G0.91193127
83CDK50.86483351
84LATS10.85029131
85PBK0.81503110
86EIF2AK10.81007914
87RPS6KA50.79599245
88PRKCE0.79048360
89PKN10.77636245
90CDK190.76360687
91PRKCG0.76284360
92MAPKAPK30.75899627
93IRAK20.74709517
94PLK30.74260538
95BCKDK0.72816526
96PLK10.72152611
97PTK2B0.69293978
98ROCK20.65730008
99PAK60.65234697
100CDK140.64930698
101KSR10.64908339
102CDK80.63981924
103EPHA20.60592936
104GRK60.59485983
105PRKACA0.59281119
106NEK10.59233663
107UHMK10.58022607
108FLT30.57878828
109RAF10.57588959
110CAMKK20.56007587
111SIK20.55857060
112PRKG10.54847867
113ABL20.54558240
114TAOK30.53062822
115DYRK30.52105928
116PHKG10.52073480
117PHKG20.52073480
118PDK20.51653155
119MAP3K70.51497605
120CSNK1E0.51399739
121DYRK20.50639161
122MELK0.50482183
123STK160.50214799
124VRK10.49935022
125MAP2K10.48366162
126CDK150.48055050
127FGFR20.47875598
128CDK180.47602818
129RIPK40.47090590
130PINK10.46469074
131STK110.46118229
132AKT30.46049831
133RPS6KA40.45494062
134DYRK1A0.45301353
135WNK30.45272108
136PRKAA10.44990933
137PRKCI0.43154823
138TIE10.42266180
139PRKAA20.41690756
140OBSCN0.38246284
141MST1R0.37774425
142PRKCQ0.37336979
143CHUK0.36992139
144PRKCA0.36067452
145CDK11A0.35747283
146ERBB20.35485931
147PIK3CG0.35263110
148CSNK1A10.34888455
149NEK90.34591211
150BRD40.33779819
151CSNK1D0.33017198
152MAP2K60.31691912

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.81211541
2Parkinsons disease_Homo sapiens_hsa050123.79448932
3Nicotine addiction_Homo sapiens_hsa050333.18758545
4Alzheimers disease_Homo sapiens_hsa050103.11879376
5Huntingtons disease_Homo sapiens_hsa050162.75114776
6Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.43387500
7Caffeine metabolism_Homo sapiens_hsa002322.28645361
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.09083480
9Collecting duct acid secretion_Homo sapiens_hsa049662.07220933
10Fanconi anemia pathway_Homo sapiens_hsa034602.01688450
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.00843127
12Primary bile acid biosynthesis_Homo sapiens_hsa001201.98521905
13Cardiac muscle contraction_Homo sapiens_hsa042601.91641571
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91055170
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.85318404
16Fatty acid elongation_Homo sapiens_hsa000621.82007296
17GABAergic synapse_Homo sapiens_hsa047271.81772934
18Butanoate metabolism_Homo sapiens_hsa006501.81127430
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.79663133
20Propanoate metabolism_Homo sapiens_hsa006401.78249944
21Sulfur metabolism_Homo sapiens_hsa009201.71951056
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.67863352
23Selenocompound metabolism_Homo sapiens_hsa004501.60591859
24Pyruvate metabolism_Homo sapiens_hsa006201.54384544
25Basal transcription factors_Homo sapiens_hsa030221.54237952
26RNA polymerase_Homo sapiens_hsa030201.49087081
27Synaptic vesicle cycle_Homo sapiens_hsa047211.47366273
28RNA degradation_Homo sapiens_hsa030181.44211893
29Taste transduction_Homo sapiens_hsa047421.43075606
30Tyrosine metabolism_Homo sapiens_hsa003501.43040772
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.43012882
32Serotonergic synapse_Homo sapiens_hsa047261.40872703
33One carbon pool by folate_Homo sapiens_hsa006701.39845658
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.38791900
35Morphine addiction_Homo sapiens_hsa050321.34303643
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33967533
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.33827649
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.31783067
39Histidine metabolism_Homo sapiens_hsa003401.30825943
40Phenylalanine metabolism_Homo sapiens_hsa003601.30275938
41Homologous recombination_Homo sapiens_hsa034401.26764091
42Renin secretion_Homo sapiens_hsa049241.25856905
43Amphetamine addiction_Homo sapiens_hsa050311.22957329
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.22561758
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.18902521
46Glutamatergic synapse_Homo sapiens_hsa047241.18554057
47Cocaine addiction_Homo sapiens_hsa050301.16782088
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14609279
49Tryptophan metabolism_Homo sapiens_hsa003801.10896803
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.09715527
51Fatty acid metabolism_Homo sapiens_hsa012121.09626120
52Vibrio cholerae infection_Homo sapiens_hsa051101.08157784
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08056498
54Arginine biosynthesis_Homo sapiens_hsa002201.07984115
55Long-term depression_Homo sapiens_hsa047301.05971775
56PPAR signaling pathway_Homo sapiens_hsa033201.04421217
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02540927
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.02074299
59Fatty acid degradation_Homo sapiens_hsa000711.01872916
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01486634
61ABC transporters_Homo sapiens_hsa020101.01094473
62Protein export_Homo sapiens_hsa030600.98135903
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97684070
64Long-term potentiation_Homo sapiens_hsa047200.97234458
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96951664
66Circadian entrainment_Homo sapiens_hsa047130.96634412
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95214893
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94133376
69Dopaminergic synapse_Homo sapiens_hsa047280.93982576
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.93588491
71Complement and coagulation cascades_Homo sapiens_hsa046100.92713289
72Olfactory transduction_Homo sapiens_hsa047400.92188507
73Starch and sucrose metabolism_Homo sapiens_hsa005000.91719509
74* Peroxisome_Homo sapiens_hsa041460.91266546
75Chemical carcinogenesis_Homo sapiens_hsa052040.91195580
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89168047
77Proteasome_Homo sapiens_hsa030500.88913479
78Steroid biosynthesis_Homo sapiens_hsa001000.87957893
79Regulation of autophagy_Homo sapiens_hsa041400.86783519
80beta-Alanine metabolism_Homo sapiens_hsa004100.86175205
81Nucleotide excision repair_Homo sapiens_hsa034200.85087541
82Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.84357775
83Nitrogen metabolism_Homo sapiens_hsa009100.84136307
84Salivary secretion_Homo sapiens_hsa049700.82346674
85Circadian rhythm_Homo sapiens_hsa047100.79801182
86Ether lipid metabolism_Homo sapiens_hsa005650.79791667
87Non-homologous end-joining_Homo sapiens_hsa034500.77723577
88Calcium signaling pathway_Homo sapiens_hsa040200.76953611
89TGF-beta signaling pathway_Homo sapiens_hsa043500.76438457
90Bile secretion_Homo sapiens_hsa049760.74230447
91Metabolic pathways_Homo sapiens_hsa011000.71551346
92Fatty acid biosynthesis_Homo sapiens_hsa000610.70038148
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.68875192
94Cholinergic synapse_Homo sapiens_hsa047250.67423111
95Vitamin digestion and absorption_Homo sapiens_hsa049770.65755515
96Vitamin B6 metabolism_Homo sapiens_hsa007500.65615729
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64270927
98Mismatch repair_Homo sapiens_hsa034300.64249381
99Arachidonic acid metabolism_Homo sapiens_hsa005900.62900890
100Linoleic acid metabolism_Homo sapiens_hsa005910.62489479
101Insulin secretion_Homo sapiens_hsa049110.61322038
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.61294304
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.60837155
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59871439
105Purine metabolism_Homo sapiens_hsa002300.56999384
106RNA transport_Homo sapiens_hsa030130.56830744
107Phototransduction_Homo sapiens_hsa047440.56019023
108Ovarian steroidogenesis_Homo sapiens_hsa049130.55181935
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54861726
110Hippo signaling pathway_Homo sapiens_hsa043900.54485499
111Gastric acid secretion_Homo sapiens_hsa049710.54092172
112Glycerolipid metabolism_Homo sapiens_hsa005610.53971602
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53813079
114Arginine and proline metabolism_Homo sapiens_hsa003300.53261172
115Glutathione metabolism_Homo sapiens_hsa004800.52971177
116Carbon metabolism_Homo sapiens_hsa012000.52957260
117Retinol metabolism_Homo sapiens_hsa008300.52578240
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51836330
119Oxytocin signaling pathway_Homo sapiens_hsa049210.51604657
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51498067
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.49138455
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.48238104
123Prion diseases_Homo sapiens_hsa050200.47963822
124Rheumatoid arthritis_Homo sapiens_hsa053230.47780102
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46953257
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.45516807
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44905750
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44179586
129Fat digestion and absorption_Homo sapiens_hsa049750.43637397
130GnRH signaling pathway_Homo sapiens_hsa049120.42796652
131Glucagon signaling pathway_Homo sapiens_hsa049220.42310585
132Sulfur relay system_Homo sapiens_hsa041220.41600876
133Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39476876
134p53 signaling pathway_Homo sapiens_hsa041150.39357728
135Gap junction_Homo sapiens_hsa045400.39342789
136Estrogen signaling pathway_Homo sapiens_hsa049150.39011357
137Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37763601
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37609691
139Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36667824
140Sphingolipid metabolism_Homo sapiens_hsa006000.36246438
1412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36229029
142Mineral absorption_Homo sapiens_hsa049780.34337157

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