PEX16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an integral peroxisomal membrane protein. An inactivating nonsense mutation localized to this gene was observed in a patient with Zellweger syndrome of the complementation group CGD/CG9. Expression of this gene product morphologically and biochemically restores the formation of new peroxisomes, suggesting a role in peroxisome organization and biogenesis. Alternative splicing has been observed for this gene and two variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.84799894
2L-phenylalanine catabolic process (GO:0006559)6.84799894
3L-phenylalanine metabolic process (GO:0006558)6.65855203
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.65855203
5aromatic amino acid family catabolic process (GO:0009074)6.02660720
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.01726505
7alpha-linolenic acid metabolic process (GO:0036109)5.53776325
8sulfur amino acid catabolic process (GO:0000098)5.53618793
9tryptophan catabolic process (GO:0006569)5.33965803
10indole-containing compound catabolic process (GO:0042436)5.33965803
11indolalkylamine catabolic process (GO:0046218)5.33965803
12glyoxylate metabolic process (GO:0046487)5.32873247
13bile acid biosynthetic process (GO:0006699)5.30353599
14kynurenine metabolic process (GO:0070189)5.18981127
15serine family amino acid catabolic process (GO:0009071)5.12664833
16urea cycle (GO:0000050)5.10417697
17urea metabolic process (GO:0019627)5.10417697
18tryptophan metabolic process (GO:0006568)5.05445547
19cysteine metabolic process (GO:0006534)5.04134253
20fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.00071314
21high-density lipoprotein particle remodeling (GO:0034375)4.98331632
22regulation of triglyceride catabolic process (GO:0010896)4.83400545
23nitrogen cycle metabolic process (GO:0071941)4.76540457
24bile acid metabolic process (GO:0008206)4.65484195
25amino-acid betaine metabolic process (GO:0006577)4.65035455
26negative regulation of fibrinolysis (GO:0051918)4.63637174
27regulation of cholesterol esterification (GO:0010872)4.58441694
28aromatic amino acid family metabolic process (GO:0009072)4.55810462
29protein carboxylation (GO:0018214)4.53934670
30peptidyl-glutamic acid carboxylation (GO:0017187)4.53934670
31complement activation, alternative pathway (GO:0006957)4.47827776
32plasma lipoprotein particle remodeling (GO:0034369)4.44454523
33protein-lipid complex remodeling (GO:0034368)4.44454523
34macromolecular complex remodeling (GO:0034367)4.44454523
35glycine metabolic process (GO:0006544)4.42570782
36cellular ketone body metabolic process (GO:0046950)4.41611752
37regulation of protein activation cascade (GO:2000257)4.41596398
38triglyceride homeostasis (GO:0070328)4.41117628
39acylglycerol homeostasis (GO:0055090)4.41117628
40regulation of fibrinolysis (GO:0051917)4.41110913
41alpha-amino acid catabolic process (GO:1901606)4.34262391
42reverse cholesterol transport (GO:0043691)4.33230715
43lysine catabolic process (GO:0006554)4.32448839
44lysine metabolic process (GO:0006553)4.32448839
45tyrosine metabolic process (GO:0006570)4.26095774
46phospholipid efflux (GO:0033700)4.24597174
47plasma lipoprotein particle clearance (GO:0034381)4.23432608
48homocysteine metabolic process (GO:0050667)4.16587647
49serine family amino acid metabolic process (GO:0009069)4.15682602
50negative regulation of cholesterol transport (GO:0032375)4.14801436
51negative regulation of sterol transport (GO:0032372)4.14801436
52regulation of complement activation (GO:0030449)4.11676876
53coenzyme catabolic process (GO:0009109)4.10187150
54cellular amino acid catabolic process (GO:0009063)4.09664502
55ethanol oxidation (GO:0006069)4.06117616
56negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.05123334
57negative regulation of cell killing (GO:0031342)4.05123334
58GDP-mannose metabolic process (GO:0019673)4.01733593
59bile acid and bile salt transport (GO:0015721)3.97219098
60serine family amino acid biosynthetic process (GO:0009070)3.96838570
61acetyl-CoA metabolic process (GO:0006084)3.91640724
62fatty acid beta-oxidation (GO:0006635)3.85140442
63indolalkylamine metabolic process (GO:0006586)3.81597688
64ketone body metabolic process (GO:1902224)3.80710574
65antigen processing and presentation of endogenous antigen (GO:0019883)3.80325296
66low-density lipoprotein particle remodeling (GO:0034374)3.79208063
67organic acid catabolic process (GO:0016054)3.78613089
68carboxylic acid catabolic process (GO:0046395)3.78613089
69positive regulation of lipoprotein lipase activity (GO:0051006)3.78403768
70positive regulation of triglyceride lipase activity (GO:0061365)3.78403768
71cellular glucuronidation (GO:0052695)3.77516376
72imidazole-containing compound metabolic process (GO:0052803)3.75664183
73cholesterol efflux (GO:0033344)3.74719657
74antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.74699922
75amine catabolic process (GO:0009310)3.74251477
76cellular biogenic amine catabolic process (GO:0042402)3.74251477
77fatty acid oxidation (GO:0019395)3.73838852
78positive regulation of lipid catabolic process (GO:0050996)3.72994138
79plasma lipoprotein particle assembly (GO:0034377)3.72906005
80short-chain fatty acid metabolic process (GO:0046459)3.70641087
81fatty acid catabolic process (GO:0009062)3.70088825
82aldehyde catabolic process (GO:0046185)3.69783326
83antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.69343768
84benzene-containing compound metabolic process (GO:0042537)3.69292258
85positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.67601320
86lipid oxidation (GO:0034440)3.67025709
87arginine metabolic process (GO:0006525)3.64383693
88monocarboxylic acid catabolic process (GO:0072329)3.63365107
89cofactor catabolic process (GO:0051187)3.62561268
90carnitine metabolic process (GO:0009437)3.60852281
91valine metabolic process (GO:0006573)3.59183609
92drug catabolic process (GO:0042737)3.57983516
93metallo-sulfur cluster assembly (GO:0031163)3.57564313
94iron-sulfur cluster assembly (GO:0016226)3.57564313
95cholesterol homeostasis (GO:0042632)3.55029847
96glutamate metabolic process (GO:0006536)3.54514271
972-oxoglutarate metabolic process (GO:0006103)3.53912246
98neutrophil activation involved in immune response (GO:0002283)3.53052698
99cellular modified amino acid catabolic process (GO:0042219)3.52730659
100base-excision repair, AP site formation (GO:0006285)3.51472843
101very-low-density lipoprotein particle assembly (GO:0034379)3.49520188
102blood coagulation, intrinsic pathway (GO:0007597)3.49141948
103positive regulation of gamma-delta T cell activation (GO:0046645)3.48177650
104negative regulation of lipase activity (GO:0060192)3.48067144
105sterol homeostasis (GO:0055092)3.46803810
106biotin metabolic process (GO:0006768)3.46507323
107flavonoid metabolic process (GO:0009812)3.45435300
108antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.44434080
109negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.43841920
110plasma lipoprotein particle organization (GO:0071827)3.43209501
111heme transport (GO:0015886)3.42657156
112branched-chain amino acid catabolic process (GO:0009083)3.42018409
113uronic acid metabolic process (GO:0006063)3.40785553
114glucuronate metabolic process (GO:0019585)3.40785553
115immunoglobulin mediated immune response (GO:0016064)3.33274998
116DNA deamination (GO:0045006)3.19571779
117purine deoxyribonucleotide catabolic process (GO:0009155)3.14129828
118negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.09201149
119response to interferon-beta (GO:0035456)2.99927770
120NIK/NF-kappaB signaling (GO:0038061)2.97876063
121positive regulation of T cell mediated cytotoxicity (GO:0001916)2.96420556
122negative regulation of innate immune response (GO:0045824)2.95702164
123autophagic vacuole fusion (GO:0000046)2.94283469
124positive regulation of B cell differentiation (GO:0045579)2.92839120
125regulation of defense response to virus by virus (GO:0050690)2.88795531
126positive regulation of T cell apoptotic process (GO:0070234)2.88671669
127regulation of interferon-beta biosynthetic process (GO:0045357)2.87897669
128detection of bacterium (GO:0016045)2.86263186
129positive regulation of defense response to virus by host (GO:0002230)2.84943967
130regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.84627922
131regulation of B cell receptor signaling pathway (GO:0050855)2.84485734
132deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.83155989
133regulation of T cell mediated cytotoxicity (GO:0001914)2.83073161
134positive regulation by symbiont of host defense response (GO:0052509)2.82690971
135modulation by symbiont of host defense response (GO:0052031)2.82690971
136modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.82690971
137modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.82690971
138positive regulation by organism of defense response of other organism involved in symbiotic interact2.82690971
139modulation by symbiont of host immune response (GO:0052553)2.82690971
140response to peptidoglycan (GO:0032494)2.81907417
141positive thymic T cell selection (GO:0045059)2.81647424
142cellular response to interferon-beta (GO:0035458)2.80486173
143cellular response to type I interferon (GO:0071357)2.77503762
144type I interferon signaling pathway (GO:0060337)2.77503762
145Arp2/3 complex-mediated actin nucleation (GO:0034314)2.76332136
146response to type I interferon (GO:0034340)2.74310345
147neutrophil activation (GO:0042119)2.72099806
148regulation of defense response to virus by host (GO:0050691)2.71925030
149positive regulation of lymphocyte apoptotic process (GO:0070230)2.70651619
150respiratory burst (GO:0045730)2.70490361
151leukocyte aggregation (GO:0070486)2.69871120
152negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.68836771
153positive regulation of antigen processing and presentation (GO:0002579)2.67907329
154detection of other organism (GO:0098543)2.66958123
155negative regulation of DNA-templated transcription, elongation (GO:0032785)2.66148560
156positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.64879666
157deoxyribonucleotide catabolic process (GO:0009264)2.64222220
158pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.61294734
159granulocyte activation (GO:0036230)2.61198415
160regulation of gamma-delta T cell activation (GO:0046643)2.58891122
161negative regulation of leukocyte mediated immunity (GO:0002704)2.58008488
162chaperone mediated protein folding requiring cofactor (GO:0051085)2.56493272
163negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.55078817
164leukocyte degranulation (GO:0043299)2.54387503
165negative regulation of phagocytosis (GO:0050765)2.54030434
166negative regulation of interleukin-12 production (GO:0032695)2.52160706
167regulation of gamma-delta T cell differentiation (GO:0045586)2.48027094
168T cell migration (GO:0072678)2.47883919
169myeloid cell activation involved in immune response (GO:0002275)2.46725052
170thymic T cell selection (GO:0045061)2.46029621
171viral protein processing (GO:0019082)2.46011112
172regulation of antigen processing and presentation (GO:0002577)2.45997704
173positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.43787345
174purine deoxyribonucleotide metabolic process (GO:0009151)2.43231547
175tolerance induction (GO:0002507)2.42349238
176negative T cell selection (GO:0043383)2.42269503
177deoxyribose phosphate catabolic process (GO:0046386)2.41585782
178negative regulation of lymphocyte mediated immunity (GO:0002707)2.41316121
179regulation of autophagic vacuole assembly (GO:2000785)2.41306622
180tumor necrosis factor-mediated signaling pathway (GO:0033209)2.39127806
181positive T cell selection (GO:0043368)2.39080845
182negative regulation of myeloid cell apoptotic process (GO:0033033)2.37448349
183T cell selection (GO:0045058)2.37063659
184negative thymic T cell selection (GO:0045060)2.36784735
185negative regulation of interleukin-6 production (GO:0032715)2.36569319
186mannosylation (GO:0097502)2.36206068
187modulation by virus of host process (GO:0019054)2.35721474
188macrophage activation involved in immune response (GO:0002281)2.35257910
189regulation of B cell differentiation (GO:0045577)2.35087168
190regulation of leukocyte mediated cytotoxicity (GO:0001910)2.34858115
191B cell mediated immunity (GO:0019724)2.32260264
192regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.32125506
193regulation of natural killer cell mediated immunity (GO:0002715)2.32125506
194positive regulation of protein homooligomerization (GO:0032464)2.31847967
195negative regulation of type I interferon production (GO:0032480)2.31556808
196B cell receptor signaling pathway (GO:0050853)2.30673537
197regulation of cell killing (GO:0031341)2.29202400
198negative regulation of tumor necrosis factor production (GO:0032720)2.28494863
199positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.27930677
200phosphatidylglycerol biosynthetic process (GO:0006655)2.27756431

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.34591161
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.41779708
3* PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.41468979
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.97692941
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.53529677
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.00406137
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.83114008
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.82655592
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.13564481
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.07070719
11VDR_21846776_ChIP-Seq_THP-1_Human2.97989176
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.66933202
13HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.09065772
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.01040871
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.4566075
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.86677559
17IRF8_21731497_ChIP-ChIP_J774_Mouse1.85875909
18ELF1_20517297_ChIP-Seq_JURKAT_Human1.85865379
19E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.85176650
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84719454
21MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.83870294
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.81165229
23UTX_26944678_Chip-Seq_JUKART_Human1.80454268
24MYC_22102868_ChIP-Seq_BL_Human1.80283118
25MAF_26560356_Chip-Seq_TH1_Human1.80026075
26CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.76970337
27MAF_26560356_Chip-Seq_TH2_Human1.73668396
28VDR_24763502_ChIP-Seq_THP-1_Human1.70554822
29TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.67758386
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.66139856
31* ELK3_25401928_ChIP-Seq_HUVEC_Human1.60496844
32STAT4_19710469_ChIP-ChIP_TH1__Mouse1.59974254
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.55724111
34* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.53570234
35* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.53564816
36SPI1_23547873_ChIP-Seq_NB4_Human1.52319891
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.47553435
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.47330176
39EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.45303523
40CIITA_25753668_ChIP-Seq_RAJI_Human1.45258861
41STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.44916657
42PU.1_20513432_ChIP-Seq_Bcells_Mouse1.44914750
43ZNF263_19887448_ChIP-Seq_K562_Human1.43992595
44E2F1_20622854_ChIP-Seq_HELA_Human1.43881570
45CLOCK_20551151_ChIP-Seq_293T_Human1.42933927
46SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.41529747
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.39268511
48DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38486898
49SA1_27219007_Chip-Seq_ERYTHROID_Human1.38340265
50SRY_22984422_ChIP-ChIP_TESTIS_Rat1.37497914
51KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.34408986
52* GABP_19822575_ChIP-Seq_HepG2_Human1.34097751
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.33988325
54HTT_18923047_ChIP-ChIP_STHdh_Human1.33912317
55* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.33745650
56* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31292300
57RXRA_24833708_ChIP-Seq_LIVER_Mouse1.30539854
58SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.29830559
59* SA1_27219007_Chip-Seq_Bcells_Human1.29419369
60* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.27521050
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27085477
62CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26298113
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.25857546
64RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.25778760
65CTCF_21964334_ChIP-Seq_BJAB-B_Human1.25638789
66NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25552529
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25513576
68LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.25511614
69RACK7_27058665_Chip-Seq_MCF-7_Human1.25413313
70ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.25014041
71CTCF_18555785_ChIP-Seq_MESCs_Mouse1.24023626
72NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23782478
73MYB_26560356_Chip-Seq_TH2_Human1.21952477
74* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21187982
75KDM2B_26808549_Chip-Seq_DND41_Human1.20985115
76* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.19360786
77SCL_19346495_ChIP-Seq_HPC-7_Human1.18797259
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18258948
79ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16812140
80CTCF_20526341_ChIP-Seq_ESCs_Human1.16333413
81CTCF_21964334_Chip-Seq_Bcells_Human1.16087305
82SMC4_20622854_ChIP-Seq_HELA_Human1.15855822
83HNF4A_19822575_ChIP-Seq_HepG2_Human1.15144899
84SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15128952
85GATA1_22025678_ChIP-Seq_K562_Human1.14921027
86THAP11_20581084_ChIP-Seq_MESCs_Mouse1.14569088
87FOXP1_21924763_ChIP-Seq_HESCs_Human1.14171250
88BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12572753
89XRN2_22483619_ChIP-Seq_HELA_Human1.11597433
90EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.11574564
91KAP1_22055183_ChIP-Seq_ESCs_Mouse1.09914314
92CREB1_15753290_ChIP-ChIP_HEK293T_Human1.07010353
93IRF8_22096565_ChIP-ChIP_GC-B_Human1.05280672
94IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02642370
95STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02026262
96RARA_24833708_ChIP-Seq_LIVER_Mouse0.99004797
97NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98734049
98FOXA2_19822575_ChIP-Seq_HepG2_Human0.98431918
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.98073395
100ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95922311
101* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93901047
102KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.93823283
103TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93734450
104BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.93594264
105ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.92606596
106RARB_24833708_ChIP-Seq_LIVER_Mouse0.92479300
107RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85874455
108SRF_21415370_ChIP-Seq_HL-1_Mouse0.83966017
109TET1_21451524_ChIP-Seq_MESCs_Mouse0.82841935
110BCOR_27268052_Chip-Seq_Bcells_Human0.79928130
111RAD21_21589869_ChIP-Seq_MESCs_Mouse0.78496290
112GATA4_25053715_ChIP-Seq_YYC3_Human0.77389319
113BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.77128701
114ETS1_20019798_ChIP-Seq_JURKAT_Human0.75991954
115PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.75539615
116PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.75068937
117MYC_18358816_ChIP-ChIP_MESCs_Mouse0.74298776
118AUTS2_25519132_ChIP-Seq_293T-REX_Human0.73844420
119BCL6_27268052_Chip-Seq_Bcells_Human0.72181901
120SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.70687191
121E2F1_18555785_ChIP-Seq_MESCs_Mouse0.70143573
122* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.67582611
123CEBPB_22108803_ChIP-Seq_LS180_Human0.66576045
124RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.65446839
125SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.65354010
126* LXR_22292898_ChIP-Seq_THP-1_Human0.63217722
127* GABP_17652178_ChIP-ChIP_JURKAT_Human0.61962298
128P300_27268052_Chip-Seq_Bcells_Human0.61044017
129CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.59559977
130P53_21459846_ChIP-Seq_SAOS-2_Human0.59142166
131ERG_20517297_ChIP-Seq_VCAP_Human0.58987769
132MYC_19915707_ChIP-ChIP_AK7_Human0.58909987
133PHF8_20622854_ChIP-Seq_HELA_Human0.58675583
134TAF2_19829295_ChIP-Seq_ESCs_Human0.58528662
135GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.58224691
136CTCF_26484167_Chip-Seq_Bcells_Mouse0.57937478
137FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.57531335
138PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.57511277
139STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.56654136
140CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.56626658
141GATA3_21867929_ChIP-Seq_CD8_Mouse0.55871290
142PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.55779444
143FLI1_21867929_ChIP-Seq_CD8_Mouse0.55422619
144RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.55179309
145RAC3_21632823_ChIP-Seq_H3396_Human0.55049546
146AR_20517297_ChIP-Seq_VCAP_Human0.54981750
147YY1_22570637_ChIP-Seq_MALME-3M_Human0.54672857
148ESR2_21235772_ChIP-Seq_MCF-7_Human0.53412513
149GATA1_22383799_ChIP-Seq_G1ME_Mouse0.53332949
150POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.53206523
151P68_20966046_ChIP-Seq_HELA_Human0.52748361
152* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.52726415
153CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.52694562
154GATA1_19941827_ChIP-Seq_MEL_Mouse0.52501710
155CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.52420823
156NANOG_20526341_ChIP-Seq_ESCs_Human0.51472550
157SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.51301297
158PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51296837
159PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.51166389
160SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.51105357

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.74321359
2MP0005360_urolithiasis6.75213305
3MP0005085_abnormal_gallbladder_physiolo5.82755141
4MP0005365_abnormal_bile_salt5.80495421
5MP0008875_abnormal_xenobiotic_pharmacok4.72960450
6MP0003806_abnormal_nucleotide_metabolis4.20806058
7MP0010329_abnormal_lipoprotein_level3.74417913
8MP0009840_abnormal_foam_cell3.68374813
9MP0003252_abnormal_bile_duct3.25553184
10MP0005671_abnormal_response_to3.16420551
11MP0001835_abnormal_antigen_presentation3.13867940
12MP0005332_abnormal_amino_acid2.83656451
13MP0005000_abnormal_immune_tolerance2.63104138
14MP0001666_abnormal_nutrient_absorption2.57934100
15MP0002148_abnormal_hypersensitivity_rea2.57223300
16MP0005083_abnormal_biliary_tract2.54110354
17MP0003195_calcinosis2.52643490
18MP0003191_abnormal_cellular_cholesterol2.52461898
19MP0001800_abnormal_humoral_immune2.48921159
20MP0009333_abnormal_splenocyte_physiolog2.48244071
21MP0003172_abnormal_lysosome_physiology2.46180109
22MP0002723_abnormal_immune_serum2.33503977
23MP0002419_abnormal_innate_immunity2.33214001
24MP0003763_abnormal_thymus_physiology2.27718056
25MP0000609_abnormal_liver_physiology2.25986689
26MP0002118_abnormal_lipid_homeostasis2.25403491
27MP0005387_immune_system_phenotype2.25279746
28MP0001790_abnormal_immune_system2.25279746
29MP0004019_abnormal_vitamin_homeostasis2.21661746
30MP0002452_abnormal_antigen_presenting2.20953707
31MP0002420_abnormal_adaptive_immunity2.20675729
32MP0001819_abnormal_immune_cell2.18203526
33MP0003303_peritoneal_inflammation2.18024280
34MP0000685_abnormal_immune_system2.11504873
35MP0002138_abnormal_hepatobiliary_system1.98123897
36MP0005319_abnormal_enzyme/_coenzyme1.93403232
37MP0001764_abnormal_homeostasis1.91151150
38MP0009278_abnormal_bone_marrow1.88628393
39MP0005670_abnormal_white_adipose1.87012987
40MP0005451_abnormal_body_composition1.85245121
41MP0003186_abnormal_redox_activity1.77944060
42MP0010155_abnormal_intestine_physiology1.69132845
43MP0000716_abnormal_immune_system1.69100620
44MP0005584_abnormal_enzyme/coenzyme_acti1.64385658
45MP0005075_abnormal_melanosome_morpholog1.64378219
46MP0002398_abnormal_bone_marrow1.59937163
47MP0001873_stomach_inflammation1.59406422
48MP0003011_delayed_dark_adaptation1.55466766
49MP0003868_abnormal_feces_composition1.53147309
50MP0001986_abnormal_taste_sensitivity1.49494935
51MP0003656_abnormal_erythrocyte_physiolo1.46629750
52MP0002876_abnormal_thyroid_physiology1.45622102
53MP0000689_abnormal_spleen_morphology1.45271626
54MP0009643_abnormal_urine_homeostasis1.44740355
55MP0002405_respiratory_system_inflammati1.43589409
56MP0001533_abnormal_skeleton_physiology1.40852068
57MP0002429_abnormal_blood_cell1.39830105
58MP0002722_abnormal_immune_system1.38790245
59MP0003866_abnormal_defecation1.36735196
60MP0006036_abnormal_mitochondrial_physio1.35454855
61MP0009697_abnormal_copulation1.32450825
62MP0003787_abnormal_imprinting1.21938772
63MP0000598_abnormal_liver_morphology1.20899272
64MP0001905_abnormal_dopamine_level1.19429136
65MP0002653_abnormal_ependyma_morphology1.17776494
66MP0005647_abnormal_sex_gland1.15836768
67MP0005310_abnormal_salivary_gland1.14890630
68MP0004130_abnormal_muscle_cell1.14262663
69MP0003123_paternal_imprinting1.11821618
70MP0000465_gastrointestinal_hemorrhage1.11274743
71MP0000703_abnormal_thymus_morphology1.06968963
72MP0005636_abnormal_mineral_homeostasis1.06141423
73MP0000604_amyloidosis1.06122745
74MP0001661_extended_life_span1.05333846
75MP0004510_myositis1.05224407
76MP0009763_increased_sensitivity_to1.04327909
77MP0002254_reproductive_system_inflammat1.04105204
78MP0001968_abnormal_touch/_nociception1.02971433
79MP0008469_abnormal_protein_level1.02967718
80MP0002163_abnormal_gland_morphology1.01833159
81MP0005666_abnormal_adipose_tissue1.01458243
82MP0009764_decreased_sensitivity_to1.00853476
83MP0000858_altered_metastatic_potential0.99620996
84MP0002971_abnormal_brown_adipose0.99413815
85MP0005397_hematopoietic_system_phenotyp0.99085212
86MP0001545_abnormal_hematopoietic_system0.99085212
87MP0003646_muscle_fatigue0.98249588
88MP0003718_maternal_effect0.97662857
89MP0003183_abnormal_peptide_metabolism0.94443586
90MP0005334_abnormal_fat_pad0.93380653
91MP0000343_altered_response_to0.91885976
92MP0009642_abnormal_blood_homeostasis0.91664454
93MP0005166_decreased_susceptibility_to0.91526262
94MP0001756_abnormal_urination0.91048050
95MP0000015_abnormal_ear_pigmentation0.90646780
96MP0002078_abnormal_glucose_homeostasis0.88884515
97MP0005535_abnormal_body_temperature0.88715183
98MP0003724_increased_susceptibility_to0.88591994
99MP0005376_homeostasis/metabolism_phenot0.87636180
100MP0001663_abnormal_digestive_system0.82649163
101MP0009765_abnormal_xenobiotic_induced0.80820762
102MP0005266_abnormal_metabolism0.80290493
103MP0002693_abnormal_pancreas_physiology0.79749915
104MP0005084_abnormal_gallbladder_morpholo0.78672542
105MP0002837_dystrophic_cardiac_calcinosis0.78309284
106MP0003705_abnormal_hypodermis_morpholog0.77441672
107MP0006035_abnormal_mitochondrial_morpho0.77224667
108MP0002933_joint_inflammation0.75655539
109MP0000490_abnormal_crypts_of0.74911188
110MP0003329_amyloid_beta_deposits0.70716813
111MP0005408_hypopigmentation0.70042151
112MP0005448_abnormal_energy_balance0.68841618
113MP0001853_heart_inflammation0.66281854
114MP0000681_abnormal_thyroid_gland0.65955244
115MP0002019_abnormal_tumor_incidence0.65788045
116MP0003690_abnormal_glial_cell0.65604504
117MP0005379_endocrine/exocrine_gland_phen0.65034714
118MP0004185_abnormal_adipocyte_glucose0.61431308
119MP0002970_abnormal_white_adipose0.60361644
120MP0009115_abnormal_fat_cell0.60272261
121MP0002822_catalepsy0.59922400
122MP0002796_impaired_skin_barrier0.59519695
123MP0005395_other_phenotype0.58428475
124MP0003436_decreased_susceptibility_to0.58407529
125MP0005220_abnormal_exocrine_pancreas0.56492660
126MP0002136_abnormal_kidney_physiology0.55869056
127MP0004782_abnormal_surfactant_physiolog0.55296109
128MP0003638_abnormal_response/metabolism_0.51455349
129MP0005058_abnormal_lysosome_morphology0.51404486
130MP0003953_abnormal_hormone_level0.51024871
131MP0008260_abnormal_autophagy0.50051952
132MP0008873_increased_physiological_sensi0.49843373
133MP0002132_abnormal_respiratory_system0.49130213
134MP0001881_abnormal_mammary_gland0.48903729
135MP0005464_abnormal_platelet_physiology0.48491409
136MP0009785_altered_susceptibility_to0.48211948
137MP0004147_increased_porphyrin_level0.48024744
138MP0000230_abnormal_systemic_arterial0.45765884
139MP0008872_abnormal_physiological_respon0.45214871
140MP0001845_abnormal_inflammatory_respons0.44912062
141MP0005375_adipose_tissue_phenotype0.44012127
142MP0000639_abnormal_adrenal_gland0.43230492
143MP0004381_abnormal_hair_follicle0.42063094
144MP0009672_abnormal_birth_weight0.40412560
145MP0001243_abnormal_dermal_layer0.39396579
146MP0010368_abnormal_lymphatic_system0.39363023
147MP0008874_decreased_physiological_sensi0.38380522
148MP0006082_CNS_inflammation0.36112643
149MP0003075_altered_response_to0.33416116
150MP0005452_abnormal_adipose_tissue0.32970951
151MP0000249_abnormal_blood_vessel0.32111133
152MP0005025_abnormal_response_to0.31248361
153MP0004947_skin_inflammation0.29629227
154MP0009053_abnormal_anal_canal0.28614445
155MP0002269_muscular_atrophy0.28143313

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.72283935
2Intrahepatic cholestasis (HP:0001406)5.93565836
3Deep venous thrombosis (HP:0002625)5.89125401
4Xanthomatosis (HP:0000991)5.87603969
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.65903216
6Hypobetalipoproteinemia (HP:0003563)5.61857134
7Prolonged partial thromboplastin time (HP:0003645)5.46174806
8Hyperlipoproteinemia (HP:0010980)5.43138700
9Hyperglycinuria (HP:0003108)4.99279259
10Hyperglycinemia (HP:0002154)4.96269324
11Abnormality of serine family amino acid metabolism (HP:0010894)4.63395158
12Abnormality of glycine metabolism (HP:0010895)4.63395158
13Hyperammonemia (HP:0001987)4.60325770
14Hypolipoproteinemia (HP:0010981)4.43765078
15Elevated erythrocyte sedimentation rate (HP:0003565)4.32857694
16Complement deficiency (HP:0004431)4.28898334
17Ketosis (HP:0001946)4.27016929
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.11246885
19Hypoalphalipoproteinemia (HP:0003233)4.06120932
20Hypoglycemic coma (HP:0001325)3.92672789
21Epidermoid cyst (HP:0200040)3.85087202
22Joint hemorrhage (HP:0005261)3.84999711
23Abnormality of glutamine family amino acid metabolism (HP:0010902)3.81877515
24* Abnormality of fatty-acid metabolism (HP:0004359)3.80971469
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.74936592
26Abnormality of sulfur amino acid metabolism (HP:0004339)3.74391965
27Abnormality of methionine metabolism (HP:0010901)3.60459833
28Abnormality of the common coagulation pathway (HP:0010990)3.54134691
29Fat malabsorption (HP:0002630)3.52553647
30Stomatitis (HP:0010280)3.48454096
31Myositis (HP:0100614)3.46550089
32Abnormality of serum amino acid levels (HP:0003112)3.41125593
33* Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.39309918
34Hypercholesterolemia (HP:0003124)3.37287076
35Abnormality of dicarboxylic acid metabolism (HP:0010995)3.34338607
36Dicarboxylic aciduria (HP:0003215)3.34338607
37Abnormality of pyrimidine metabolism (HP:0004353)3.33600291
38Recurrent abscess formation (HP:0002722)3.32927715
39Abnormality of macrophages (HP:0004311)3.22099150
40Ketoacidosis (HP:0001993)3.17464705
41Conjugated hyperbilirubinemia (HP:0002908)3.13563757
42Lethargy (HP:0001254)3.12515438
43Abnormality of the intrinsic pathway (HP:0010989)3.11352598
44Abnormality of complement system (HP:0005339)3.09833490
45Abnormality of liposaccharide metabolism (HP:0010968)3.07151543
46Abnormality of glycosphingolipid metabolism (HP:0004343)3.07151543
47Abnormality of glycolipid metabolism (HP:0010969)3.07151543
48Recurrent bacterial skin infections (HP:0005406)3.03721990
49Hyperbilirubinemia (HP:0002904)3.03109376
50Hepatocellular necrosis (HP:0001404)2.99793898
51Abnormality of nucleobase metabolism (HP:0010932)2.97449299
52Gout (HP:0001997)2.92473248
53Increased neuronal autofluorescent lipopigment (HP:0002074)2.91687906
54Increased cerebral lipofuscin (HP:0011813)2.91664932
55Metabolic acidosis (HP:0001942)2.91470496
56Mediastinal lymphadenopathy (HP:0100721)2.91322301
57Cerebral edema (HP:0002181)2.86839552
58Obstructive lung disease (HP:0006536)2.86079979
59Chronic obstructive pulmonary disease (HP:0006510)2.86079979
60Abnormality of purine metabolism (HP:0004352)2.79373803
61Eczematoid dermatitis (HP:0000976)2.79291301
62Dysostosis multiplex (HP:0000943)2.79229941
63Delayed CNS myelination (HP:0002188)2.75352876
64Orchitis (HP:0100796)2.73685793
65Skin nodule (HP:0200036)2.72165010
66Steatorrhea (HP:0002570)2.69094653
67Mitochondrial inheritance (HP:0001427)2.66940679
68Increased serum ferritin (HP:0003281)2.66587835
69Vacuolated lymphocytes (HP:0001922)2.64995118
70Petechiae (HP:0000967)2.62484964
71Increased intramyocellular lipid droplets (HP:0012240)2.62025191
72Myocardial infarction (HP:0001658)2.58909703
73Generalized aminoaciduria (HP:0002909)2.57974318
74Abnormality of mucopolysaccharide metabolism (HP:0011020)2.52675163
75Abnormality of polysaccharide metabolism (HP:0011012)2.52675163
76Abnormality of glycosaminoglycan metabolism (HP:0004371)2.52675163
77Meningitis (HP:0001287)2.50748091
78Optic neuritis (HP:0100653)2.50680218
79Retrobulbar optic neuritis (HP:0100654)2.50680218
80Spontaneous abortion (HP:0005268)2.50647343
81Hepatocellular carcinoma (HP:0001402)2.44060659
82Irritability (HP:0000737)2.43627506
83Vomiting (HP:0002013)2.41509368
84Systemic lupus erythematosus (HP:0002725)2.41276369
85Increased IgM level (HP:0003496)2.39965980
86Abnormal mitochondria in muscle tissue (HP:0008316)2.39805825
87Hepatic necrosis (HP:0002605)2.38043620
88Absent rod-and cone-mediated responses on ERG (HP:0007688)2.35663082
89Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.34610983
90Abnormal delayed hypersensitivity skin test (HP:0002963)2.33307334
91J-shaped sella turcica (HP:0002680)2.32100930
92Progressive microcephaly (HP:0000253)2.30721120
93Pustule (HP:0200039)2.30569442
94Prolonged neonatal jaundice (HP:0006579)2.30418786
95Pancreatitis (HP:0001733)2.29864194
96Encephalitis (HP:0002383)2.29204578
97Vasculitis (HP:0002633)2.29195242
98Hypertriglyceridemia (HP:0002155)2.29046920
99Recurrent fungal infections (HP:0002841)2.28235305
100Urticaria (HP:0001025)2.26614543
101Abnormal gallbladder morphology (HP:0012437)2.26375871
102Urinary glycosaminoglycan excretion (HP:0003541)2.25879917
103Mucopolysacchariduria (HP:0008155)2.25879917
104Acanthocytosis (HP:0001927)2.25856391
105Nausea (HP:0002018)2.25352707
106Malnutrition (HP:0004395)2.24249403
107Cholelithiasis (HP:0001081)2.23276864
108Increased CSF lactate (HP:0002490)2.23255553
109Type I transferrin isoform profile (HP:0003642)2.21475462
110Opisthotonus (HP:0002179)2.20313858
111Acute necrotizing encephalopathy (HP:0006965)2.20255722
112Hypoglycemic seizures (HP:0002173)2.18799259
113Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.17584897
114* Brushfield spots (HP:0001088)2.17403060
115Neonatal onset (HP:0003623)2.14912231
116Abnormal protein glycosylation (HP:0012346)2.14495740
117Abnormal glycosylation (HP:0012345)2.14495740
118Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.14495740
119Abnormal protein N-linked glycosylation (HP:0012347)2.14495740
120Late onset (HP:0003584)2.14384125
121Decreased electroretinogram (ERG) amplitude (HP:0000654)2.13984224
122Abnormal cartilage morphology (HP:0002763)2.13843522
123Spastic diplegia (HP:0001264)2.12443812
124Proximal tubulopathy (HP:0000114)2.12423526
125Vascular calcification (HP:0004934)2.11854853
126Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.11766234
127Progressive neurologic deterioration (HP:0002344)2.11199463
128Hepatosplenomegaly (HP:0001433)2.10328786
129Sensorimotor neuropathy (HP:0007141)2.09962824
130Recurrent skin infections (HP:0001581)2.09030142
131Pulmonary infiltrates (HP:0002113)2.09022544
132Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.08963908
133Visual hallucinations (HP:0002367)2.08953067
134Glycosuria (HP:0003076)2.07927044
135Abnormality of urine glucose concentration (HP:0011016)2.07927044
136Decreased activity of mitochondrial respiratory chain (HP:0008972)2.07386753
137Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.07386753
138Lymphopenia (HP:0001888)2.07053739
139Abnormality of T cells (HP:0002843)2.06903544
140Cerebral palsy (HP:0100021)2.06668530
141Agammaglobulinemia (HP:0004432)2.05772420
142Loss of speech (HP:0002371)2.05016326
143Microretrognathia (HP:0000308)2.03730489
144Amyloidosis (HP:0011034)2.02933077
145Hyperuricemia (HP:0002149)2.02432020
146Increased purine levels (HP:0004368)2.02432020
147Lactic acidosis (HP:0003128)2.00852842
148Gastrointestinal inflammation (HP:0004386)2.00341029
149Inflammation of the large intestine (HP:0002037)1.97740948
150Recurrent viral infections (HP:0004429)1.96756963
151IgG deficiency (HP:0004315)1.96290690
1523-Methylglutaconic aciduria (HP:0003535)1.95843599
153Panhypogammaglobulinemia (HP:0003139)1.93838138
154Cholecystitis (HP:0001082)1.92980430
155Abnormal gallbladder physiology (HP:0012438)1.92980430
156Lipid accumulation in hepatocytes (HP:0006561)1.92239735
157Spastic paraparesis (HP:0002313)1.92101837
158Increased serum lactate (HP:0002151)1.91802620
159Acute encephalopathy (HP:0006846)1.91526155
160Hydroxyprolinuria (HP:0003080)1.91373189
161Abnormality of proline metabolism (HP:0010907)1.91373189
162Hypochromic microcytic anemia (HP:0004840)1.90351501
163Elevated hepatic transaminases (HP:0002910)1.89212393
164Gastrointestinal infarctions (HP:0005244)1.89007860
165Increased muscle lipid content (HP:0009058)1.88728439
166Gastrointestinal stroma tumor (HP:0100723)1.88603655
167Recurrent gram-negative bacterial infections (HP:0005420)1.88218747
168Menorrhagia (HP:0000132)1.87190770
169Anorexia (HP:0002039)1.87180875
170Purpura (HP:0000979)1.87132972
171Alkalosis (HP:0001948)1.85354615
172CNS demyelination (HP:0007305)1.85181350
173Leukocytosis (HP:0001974)1.85025213
174Hyperglycemia (HP:0003074)1.84801591
175Glomerulonephritis (HP:0000099)1.84174891
176Abnormality of transition element cation homeostasis (HP:0011030)1.84102400
177Abnormality of cells of the lymphoid lineage (HP:0012140)1.83713208
178Cardiovascular calcification (HP:0011915)1.82510030
179Mitral stenosis (HP:0001718)1.82381255
180Gingival bleeding (HP:0000225)1.82345063
181Colitis (HP:0002583)1.81722435
182Abnormality of iron homeostasis (HP:0011031)1.81709635
183Recurrent cutaneous fungal infections (HP:0011370)1.81697720
184Chronic mucocutaneous candidiasis (HP:0002728)1.81697720
185Abnormality of T cell physiology (HP:0011840)1.80679028
186Renal cortical cysts (HP:0000803)1.80576804
187Hemorrhage of the eye (HP:0011885)1.79151089
188Hypertensive crisis (HP:0100735)1.78781721
189Hypergammaglobulinemia (HP:0010702)1.78401756
190Hypochromic anemia (HP:0001931)1.77843705

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.47455307
2EIF2AK14.09831096
3ERN14.05242652
4SIK13.21821244
5FGFR43.01861299
6MAP3K112.75496917
7VRK22.69853443
8EIF2AK32.69718685
9ARAF2.40280005
10MST1R2.24629106
11RIPK42.17091781
12NME22.15233251
13TXK2.07729701
14ACVR1B1.94312135
15INSRR1.89375969
16TESK11.88539036
17IRAK31.84704303
18TNK21.83338168
19PDK41.81271367
20PDK31.81271367
21FLT31.81050001
22TLK11.79978706
23PBK1.79273358
24TRIB31.77934292
25FES1.76723397
26CDK191.76618443
27TYK21.75959658
28STK161.74956415
29SMG11.71261628
30TAOK31.62154401
31EPHB11.59512424
32ABL21.55823317
33MAPKAPK31.41377456
34PRPF4B1.41181604
35KDR1.39985482
36BRAF1.33842146
37MAPK111.31596542
38PIK3CG1.31404260
39PINK11.29270582
40ERBB41.24273650
41BUB11.22819794
42ZAK1.22601340
43BRSK11.19417406
44SYK1.17200662
45TBK11.16397567
46PKN21.12423040
47MAP2K31.12283786
48PDK21.10627686
49MAP3K31.07546697
50DAPK11.06063160
51TAOK10.97883255
52MAP2K40.97815438
53TESK20.97141153
54AKT30.97101147
55MAP2K60.94310699
56GRK60.93816480
57CAMK1D0.92706525
58JAK30.91865009
59NEK90.91331422
60ITK0.90176458
61GRK50.89003728
62HIPK20.87010279
63EIF2AK20.85902770
64MAPK40.85579044
65ERBB20.84539352
66JAK20.83634421
67PRKAA20.83446999
68CDK40.83017664
69ADRBK20.82105612
70LYN0.81287714
71PRKD20.80033450
72LCK0.79714429
73HCK0.79023226
74ZAP700.78371050
75ICK0.78112935
76MAP2K10.74660826
77PIM10.72696285
78WEE10.71756587
79STK38L0.71608389
80MAP2K20.71388800
81PRKCI0.70904321
82MAPK70.70792864
83CAMKK10.70623343
84RPS6KL10.67740455
85RPS6KA20.67415907
86PRKACG0.67384124
87EPHA20.67294879
88LIMK10.67167411
89JAK10.67152071
90LRRK20.65087337
91SIK30.64499016
92MAP4K10.64371783
93CSK0.62873964
94PRKCQ0.62431542
95RPS6KA40.62371906
96BLK0.61632363
97PDPK10.61424875
98PRKCZ0.61374349
99GRK70.61298098
100PTK60.60217514
101MAP3K70.59813771
102NEK10.58503790
103MATK0.58415439
104MAPK120.57901656
105IKBKE0.57332598
106CAMK2G0.57161010
107RPS6KA50.57156298
108SIK20.55864361
109MARK20.55749050
110PRKAA10.55479558
111VRK10.54867907
112MAP3K10.53566095
113DAPK30.53105814
114MUSK0.51441788
115CSNK1G30.48346675
116MAP2K70.47394621
117CDK60.47351872
118STK110.46689224
119KIT0.45935017
120MAP3K130.45299800
121MAP3K140.44582144
122PAK10.43688715
123GSK3A0.43474139
124TIE10.42694712
125DYRK20.41416819
126DAPK20.39206652
127DYRK30.37933383
128PRKCH0.37090599
129MYLK0.36529875
130MAPK150.35943893
131PDK10.35564840
132PRKCD0.34472116
133IRAK20.34416372
134PIM20.32949810
135CSF1R0.32258602
136RAF10.31999962
137SCYL20.31818467
138MAP4K20.31792321
139IKBKB0.31115875
140CSNK1G10.27065636
141CSNK2A10.26451732
142BTK0.26383275
143BMPR1B0.26025144
144MET0.25546857
145PRKCG0.25389080
146PRKCA0.20615263
147AURKA0.19231994
148RPS6KA60.19091838
149TGFBR10.18776417
150GRK10.18663064
151FRK0.18603583
152IRAK40.18454178
153IRAK10.18429511
154IGF1R0.18342481
155TAOK20.18257622
156RPS6KC10.18256850

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.97099754
2Primary immunodeficiency_Homo sapiens_hsa053403.24304606
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.04152403
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.82563032
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.77661785
6Other glycan degradation_Homo sapiens_hsa005112.69087739
7Nitrogen metabolism_Homo sapiens_hsa009102.66616571
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.64849116
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.63818891
10Arginine biosynthesis_Homo sapiens_hsa002202.63224339
11Fatty acid degradation_Homo sapiens_hsa000712.62635217
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.55420514
13Allograft rejection_Homo sapiens_hsa053302.52376835
14Graft-versus-host disease_Homo sapiens_hsa053322.50616902
15Tryptophan metabolism_Homo sapiens_hsa003802.43637534
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.37429519
17Autoimmune thyroid disease_Homo sapiens_hsa053202.36747554
18Propanoate metabolism_Homo sapiens_hsa006402.27112701
19Glycosaminoglycan degradation_Homo sapiens_hsa005312.24377681
20Pentose and glucuronate interconversions_Homo sapiens_hsa000402.23596498
21Butanoate metabolism_Homo sapiens_hsa006502.22946513
22Complement and coagulation cascades_Homo sapiens_hsa046102.17497340
23* Peroxisome_Homo sapiens_hsa041462.11916799
24Intestinal immune network for IgA production_Homo sapiens_hsa046722.09977637
25PPAR signaling pathway_Homo sapiens_hsa033202.07765278
26Fatty acid metabolism_Homo sapiens_hsa012122.05078400
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.00549539
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.86884953
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.86772119
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.85002265
31Chemical carcinogenesis_Homo sapiens_hsa052041.83623330
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.83467683
33Antigen processing and presentation_Homo sapiens_hsa046121.83260883
34beta-Alanine metabolism_Homo sapiens_hsa004101.79655677
35Histidine metabolism_Homo sapiens_hsa003401.77352275
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.75769438
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.75292981
38Type I diabetes mellitus_Homo sapiens_hsa049401.75125148
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.73730135
40Sulfur metabolism_Homo sapiens_hsa009201.72693430
41Leishmaniasis_Homo sapiens_hsa051401.72673754
42Asthma_Homo sapiens_hsa053101.70019595
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69416258
44Caffeine metabolism_Homo sapiens_hsa002321.69296420
45Vitamin B6 metabolism_Homo sapiens_hsa007501.68788035
46Fatty acid elongation_Homo sapiens_hsa000621.65911539
47Retinol metabolism_Homo sapiens_hsa008301.63076527
48Osteoclast differentiation_Homo sapiens_hsa043801.62961275
49Pyruvate metabolism_Homo sapiens_hsa006201.60748122
50Rheumatoid arthritis_Homo sapiens_hsa053231.60475355
51Ribosome_Homo sapiens_hsa030101.59389392
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.57490463
53Toll-like receptor signaling pathway_Homo sapiens_hsa046201.54305946
54Folate biosynthesis_Homo sapiens_hsa007901.53926915
55NF-kappa B signaling pathway_Homo sapiens_hsa040641.48621833
56RNA polymerase_Homo sapiens_hsa030201.48437891
57Selenocompound metabolism_Homo sapiens_hsa004501.47196323
58Tuberculosis_Homo sapiens_hsa051521.44761694
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.43191923
60Phenylalanine metabolism_Homo sapiens_hsa003601.43000281
61Cysteine and methionine metabolism_Homo sapiens_hsa002701.42821147
62Carbon metabolism_Homo sapiens_hsa012001.41744141
63Staphylococcus aureus infection_Homo sapiens_hsa051501.40288413
64Fat digestion and absorption_Homo sapiens_hsa049751.40274807
65Sulfur relay system_Homo sapiens_hsa041221.38170423
66B cell receptor signaling pathway_Homo sapiens_hsa046621.35618289
67Tyrosine metabolism_Homo sapiens_hsa003501.34177383
68SNARE interactions in vesicular transport_Homo sapiens_hsa041301.30493077
69Biosynthesis of amino acids_Homo sapiens_hsa012301.30314944
70Hematopoietic cell lineage_Homo sapiens_hsa046401.26700207
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.24719092
72Base excision repair_Homo sapiens_hsa034101.24537251
73T cell receptor signaling pathway_Homo sapiens_hsa046601.24331531
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.22377433
75Collecting duct acid secretion_Homo sapiens_hsa049661.22309023
76Starch and sucrose metabolism_Homo sapiens_hsa005001.19635296
77Bile secretion_Homo sapiens_hsa049761.18114590
78Viral myocarditis_Homo sapiens_hsa054161.16759219
79Acute myeloid leukemia_Homo sapiens_hsa052211.15380960
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15335149
81Steroid biosynthesis_Homo sapiens_hsa001001.10894022
82Pentose phosphate pathway_Homo sapiens_hsa000301.09006564
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.08906522
84Herpes simplex infection_Homo sapiens_hsa051681.07020071
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.06659433
86Cyanoamino acid metabolism_Homo sapiens_hsa004601.06383732
87Malaria_Homo sapiens_hsa051441.05691047
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04026269
89ABC transporters_Homo sapiens_hsa020101.02910366
90NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02592490
91Vitamin digestion and absorption_Homo sapiens_hsa049770.99619750
92Arginine and proline metabolism_Homo sapiens_hsa003300.98137487
93Glycerolipid metabolism_Homo sapiens_hsa005610.97973703
94Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96967834
95Measles_Homo sapiens_hsa051620.95738291
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93952892
97Influenza A_Homo sapiens_hsa051640.90147992
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89729015
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.88217513
100Synaptic vesicle cycle_Homo sapiens_hsa047210.86859008
101Glutathione metabolism_Homo sapiens_hsa004800.85090739
102Fatty acid biosynthesis_Homo sapiens_hsa000610.83260777
103Shigellosis_Homo sapiens_hsa051310.83161524
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83060922
105Pertussis_Homo sapiens_hsa051330.81741607
106Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80369822
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80342110
108Legionellosis_Homo sapiens_hsa051340.80138277
109Phagosome_Homo sapiens_hsa041450.79166942
110Vibrio cholerae infection_Homo sapiens_hsa051100.76696168
111Epstein-Barr virus infection_Homo sapiens_hsa051690.75964553
112Apoptosis_Homo sapiens_hsa042100.74415582
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72783978
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66268007
115Metabolic pathways_Homo sapiens_hsa011000.63512815
116Fructose and mannose metabolism_Homo sapiens_hsa000510.59940452
117Salmonella infection_Homo sapiens_hsa051320.58892812
118TNF signaling pathway_Homo sapiens_hsa046680.58716316
119Chemokine signaling pathway_Homo sapiens_hsa040620.57908015
120Endocytosis_Homo sapiens_hsa041440.57678189
121VEGF signaling pathway_Homo sapiens_hsa043700.57571231
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57272490
123One carbon pool by folate_Homo sapiens_hsa006700.56759634
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55008491
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54740788
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53882270
127African trypanosomiasis_Homo sapiens_hsa051430.53401773
128Toxoplasmosis_Homo sapiens_hsa051450.51515358
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51304118
130Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50354291
131N-Glycan biosynthesis_Homo sapiens_hsa005100.50132370
132Linoleic acid metabolism_Homo sapiens_hsa005910.49749020
133Galactose metabolism_Homo sapiens_hsa000520.48193727
134Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47241090
135Lysine degradation_Homo sapiens_hsa003100.45102669
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.43543001
137Hepatitis B_Homo sapiens_hsa051610.41140139
138Jak-STAT signaling pathway_Homo sapiens_hsa046300.38977007
139Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.38743420
140Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38729166
141Proteasome_Homo sapiens_hsa030500.37558302
142Adipocytokine signaling pathway_Homo sapiens_hsa049200.30092251
143Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25090957
144Oxidative phosphorylation_Homo sapiens_hsa001900.22621125
145Regulation of autophagy_Homo sapiens_hsa041400.17969019
146Insulin resistance_Homo sapiens_hsa049310.16471385
147Parkinsons disease_Homo sapiens_hsa050120.13154478
148Arachidonic acid metabolism_Homo sapiens_hsa005900.12137111
149AMPK signaling pathway_Homo sapiens_hsa041520.10759822
150Prion diseases_Homo sapiens_hsa050200.09533000
151Pyrimidine metabolism_Homo sapiens_hsa002400.07113215
152Glucagon signaling pathway_Homo sapiens_hsa049220.00271727
153Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1846478
154Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1836832
155RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1827940
156Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1818944
157Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1808731
158Hepatitis C_Homo sapiens_hsa05160-0.1733633
159Lysosome_Homo sapiens_hsa04142-0.1628080
160Purine metabolism_Homo sapiens_hsa00230-0.1426600
161Ether lipid metabolism_Homo sapiens_hsa00565-0.1341559
162Huntingtons disease_Homo sapiens_hsa05016-0.1023895
163Insulin signaling pathway_Homo sapiens_hsa04910-0.0682477
164Alzheimers disease_Homo sapiens_hsa05010-0.0383659
165Renin-angiotensin system_Homo sapiens_hsa04614-0.0141476

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »