PEX19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is necessary for early peroxisomal biogenesis. It acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. These disorders have at least 14 complementation groups, with more than one phenotype being observed for some complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of Zellweger syndrome (ZWS), as well as peroxisome biogenesis disorder complementation group 14 (PBD-CG14), which is also known as PBD-CGJ. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.76700780
2L-phenylalanine catabolic process (GO:0006559)5.76700780
3alpha-linolenic acid metabolic process (GO:0036109)5.66178503
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.54301602
5L-phenylalanine metabolic process (GO:0006558)5.54301602
6lysine metabolic process (GO:0006553)5.03802916
7lysine catabolic process (GO:0006554)5.03802916
8aromatic amino acid family catabolic process (GO:0009074)4.97766946
9glyoxylate metabolic process (GO:0046487)4.92004232
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.90908432
11fatty acid beta-oxidation (GO:0006635)4.65179723
12L-serine metabolic process (GO:0006563)4.65118284
13fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.64479983
14kynurenine metabolic process (GO:0070189)4.55835062
152-oxoglutarate metabolic process (GO:0006103)4.54065641
16acetyl-CoA metabolic process (GO:0006084)4.49629403
17regulation of triglyceride catabolic process (GO:0010896)4.39530709
18tryptophan catabolic process (GO:0006569)4.34515673
19indole-containing compound catabolic process (GO:0042436)4.34515673
20indolalkylamine catabolic process (GO:0046218)4.34515673
21bile acid biosynthetic process (GO:0006699)4.31392921
22cellular ketone body metabolic process (GO:0046950)4.29996166
23sulfur amino acid catabolic process (GO:0000098)4.29508646
24tricarboxylic acid cycle (GO:0006099)4.28037518
25fatty acid oxidation (GO:0019395)4.24704586
26amino-acid betaine metabolic process (GO:0006577)4.24699685
27fatty acid catabolic process (GO:0009062)4.21372514
28positive regulation of fatty acid beta-oxidation (GO:0032000)4.21230169
29biotin metabolic process (GO:0006768)4.19237851
30lipid oxidation (GO:0034440)4.18458296
31branched-chain amino acid catabolic process (GO:0009083)4.18449349
32fatty acid transmembrane transport (GO:1902001)4.17119386
33tryptophan metabolic process (GO:0006568)4.11194510
34aspartate family amino acid catabolic process (GO:0009068)4.09835524
35NADH metabolic process (GO:0006734)4.09660035
36valine metabolic process (GO:0006573)4.07861553
37serine family amino acid catabolic process (GO:0009071)4.06128623
38urea metabolic process (GO:0019627)4.05938866
39urea cycle (GO:0000050)4.05938866
40regulation of sequestering of triglyceride (GO:0010889)4.05488726
41cysteine metabolic process (GO:0006534)4.01874679
42COPI coating of Golgi vesicle (GO:0048205)4.01632449
43Golgi transport vesicle coating (GO:0048200)4.01632449
44negative regulation of fibrinolysis (GO:0051918)3.99929722
45monocarboxylic acid catabolic process (GO:0072329)3.98411008
46oxaloacetate metabolic process (GO:0006107)3.97174023
47alpha-amino acid catabolic process (GO:1901606)3.92888083
48complement activation, alternative pathway (GO:0006957)3.92219926
49plasma lipoprotein particle clearance (GO:0034381)3.91531804
50acylglycerol homeostasis (GO:0055090)3.90639986
51triglyceride homeostasis (GO:0070328)3.90639986
52carnitine shuttle (GO:0006853)3.86176312
53hexose biosynthetic process (GO:0019319)3.83903152
54positive regulation of fatty acid oxidation (GO:0046321)3.83793732
55branched-chain amino acid metabolic process (GO:0009081)3.83408815
56homocysteine metabolic process (GO:0050667)3.77762273
57gluconeogenesis (GO:0006094)3.77297484
58thioester biosynthetic process (GO:0035384)3.77119252
59acyl-CoA biosynthetic process (GO:0071616)3.77119252
60positive regulation of lipid catabolic process (GO:0050996)3.76095366
61high-density lipoprotein particle remodeling (GO:0034375)3.74026488
62short-chain fatty acid metabolic process (GO:0046459)3.73964832
63cellular amino acid catabolic process (GO:0009063)3.73886654
64nitrogen cycle metabolic process (GO:0071941)3.73101443
65ketone body metabolic process (GO:1902224)3.70998951
66bile acid metabolic process (GO:0008206)3.68918103
67regulation of fatty acid beta-oxidation (GO:0031998)3.65830605
68carnitine metabolic process (GO:0009437)3.65761310
69carboxylic acid catabolic process (GO:0046395)3.64625439
70organic acid catabolic process (GO:0016054)3.64625439
71monosaccharide biosynthetic process (GO:0046364)3.63753767
72tyrosine metabolic process (GO:0006570)3.63453322
73coenzyme catabolic process (GO:0009109)3.61194088
74aromatic amino acid family metabolic process (GO:0009072)3.59830237
75tricarboxylic acid metabolic process (GO:0072350)3.58023624
76regulation of protein activation cascade (GO:2000257)3.56641270
77peptidyl-glutamic acid carboxylation (GO:0017187)3.55602243
78protein carboxylation (GO:0018214)3.55602243
79fatty-acyl-CoA biosynthetic process (GO:0046949)3.55199835
80regulation of fibrinolysis (GO:0051917)3.54108892
81regulation of fatty acid oxidation (GO:0046320)3.53801261
82acyl-CoA metabolic process (GO:0006637)3.52199420
83thioester metabolic process (GO:0035383)3.52199420
84serine family amino acid biosynthetic process (GO:0009070)3.49984751
85low-density lipoprotein particle clearance (GO:0034383)3.49059479
86reverse cholesterol transport (GO:0043691)3.46852911
87regulation of cholesterol esterification (GO:0010872)3.43825682
88plasma lipoprotein particle remodeling (GO:0034369)3.43202409
89protein-lipid complex remodeling (GO:0034368)3.43202409
90macromolecular complex remodeling (GO:0034367)3.43202409
91triglyceride catabolic process (GO:0019433)3.42338400
92very long-chain fatty acid metabolic process (GO:0000038)3.42057142
93ethanol oxidation (GO:0006069)3.41556055
94succinate metabolic process (GO:0006105)3.40544041
95neutral lipid catabolic process (GO:0046461)3.36095136
96acylglycerol catabolic process (GO:0046464)3.36095136
97regulation of complement activation (GO:0030449)3.34689431
98coenzyme A metabolic process (GO:0015936)3.34153925
99fatty acid homeostasis (GO:0055089)3.33842115
100cellular modified amino acid catabolic process (GO:0042219)3.29667311
101glutamate metabolic process (GO:0006536)3.26766125
102glycine metabolic process (GO:0006544)3.26383116
103dicarboxylic acid biosynthetic process (GO:0043650)3.26336918
104fatty-acyl-CoA metabolic process (GO:0035337)3.26167080
105aldehyde catabolic process (GO:0046185)3.24007558
106serine family amino acid metabolic process (GO:0009069)3.21964461
107pyrimidine nucleobase catabolic process (GO:0006208)3.20791425
108establishment of integrated proviral latency (GO:0075713)3.15031667
109regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.11931613
110protein complex localization (GO:0031503)3.01361976
111daunorubicin metabolic process (GO:0044597)3.00215881
112polyketide metabolic process (GO:0030638)3.00215881
113doxorubicin metabolic process (GO:0044598)3.00215881
114nucleotide-sugar biosynthetic process (GO:0009226)2.93992752
115IMP biosynthetic process (GO:0006188)2.92344961
116lipid particle organization (GO:0034389)2.88161978
117paraxial mesoderm development (GO:0048339)2.86256264
118negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.82980832
119NADPH regeneration (GO:0006740)2.82714402
120response to phenylpropanoid (GO:0080184)2.79570006
121regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.77939376
122oxidative phosphorylation (GO:0006119)2.75307094
123establishment of viral latency (GO:0019043)2.75076557
124protein maturation by protein folding (GO:0022417)2.74989700
125glycerolipid catabolic process (GO:0046503)2.74837736
126ethanol metabolic process (GO:0006067)2.71793192
127long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.70545444
128cellular protein complex localization (GO:0034629)2.70219036
129IMP metabolic process (GO:0046040)2.69251499
130proline biosynthetic process (GO:0006561)2.68617031
131regulation of coenzyme metabolic process (GO:0051196)2.68515130
132regulation of cofactor metabolic process (GO:0051193)2.68515130
133negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.68341058
134negative regulation of ligase activity (GO:0051352)2.68341058
135coenzyme A biosynthetic process (GO:0015937)2.67633751
136regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.67182254
137acylglycerol biosynthetic process (GO:0046463)2.64822528
138neutral lipid biosynthetic process (GO:0046460)2.64822528
139anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.64336958
140triglyceride biosynthetic process (GO:0019432)2.63653592
141aminoglycoside antibiotic metabolic process (GO:0030647)2.63307373
142ribosome assembly (GO:0042255)2.62874226
143positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.62615619
144COPII vesicle coating (GO:0048208)2.60169092
145mitotic metaphase plate congression (GO:0007080)2.59591186
146long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.58405460
147regulation of mitotic spindle organization (GO:0060236)2.56719292
148galactose catabolic process (GO:0019388)2.56323658
149purine nucleobase biosynthetic process (GO:0009113)2.55750940
150cholesterol biosynthetic process (GO:0006695)2.54518604
151glycolytic process (GO:0006096)2.53436415
152pyruvate metabolic process (GO:0006090)2.53135023
153diacylglycerol metabolic process (GO:0046339)2.51245529
154regulation of cellular amino acid metabolic process (GO:0006521)2.50240513
155glycogen catabolic process (GO:0005980)2.49063370

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.82839126
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse9.14230594
3* RXR_22158963_ChIP-Seq_LIVER_Mouse6.89715557
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.94726977
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.39735636
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.45075315
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.44729992
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.19580160
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.89720872
10E2F7_22180533_ChIP-Seq_HELA_Human3.50908033
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.50571485
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.35187019
13CLOCK_20551151_ChIP-Seq_293T_Human3.31760787
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.26746874
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.92668073
16CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.90243224
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.88911244
18AR_21909140_ChIP-Seq_LNCAP_Human2.88713168
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.56515844
20ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.39119930
21* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.28624502
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.21807900
23* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.16039493
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.15378788
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12707010
26ZFX_18555785_ChIP-Seq_MESCs_Mouse2.09255579
27* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.07560857
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.06392151
29RARG_19884340_ChIP-ChIP_MEFs_Mouse2.05182828
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.96021389
31ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.95913415
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.95691414
33NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.91075918
34TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.87972280
35HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.87476560
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87128454
37XRN2_22483619_ChIP-Seq_HELA_Human1.77045446
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.73216694
39* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.72545334
40* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.71101070
41ETS1_20019798_ChIP-Seq_JURKAT_Human1.68989077
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.67521908
43PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.64962080
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57233448
45EST1_17652178_ChIP-ChIP_JURKAT_Human1.56570970
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.54847410
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52644788
48* SOX17_20123909_ChIP-Seq_XEN_Mouse1.52258682
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48145271
50* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45325290
51KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.44511598
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42896939
53WT1_19549856_ChIP-ChIP_CCG9911_Human1.36930681
54ZNF263_19887448_ChIP-Seq_K562_Human1.34306720
55DCP1A_22483619_ChIP-Seq_HELA_Human1.33933848
56NANOG_21062744_ChIP-ChIP_HESCs_Human1.33394928
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.31158564
58FOXA2_19822575_ChIP-Seq_HepG2_Human1.29641737
59NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.28120606
60OCT4_18692474_ChIP-Seq_MEFs_Mouse1.27994524
61TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27259007
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25532754
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.25151041
64SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.23826497
65PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22552864
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22004014
67SOX2_18692474_ChIP-Seq_MEFs_Mouse1.21658557
68HTT_18923047_ChIP-ChIP_STHdh_Human1.19034698
69SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.18971844
70TCF3_18692474_ChIP-Seq_MEFs_Mouse1.18744821
71TFEB_21752829_ChIP-Seq_HELA_Human1.18451360
72ELK1_19687146_ChIP-ChIP_HELA_Human1.16769951
73TTF2_22483619_ChIP-Seq_HELA_Human1.16643825
74SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.16349859
75NANOG_16153702_ChIP-ChIP_HESCs_Human1.15574120
76ELF1_17652178_ChIP-ChIP_JURKAT_Human1.15112699
77ESR1_20079471_ChIP-ChIP_T-47D_Human1.13902491
78KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13510116
79HNF4A_19822575_ChIP-Seq_HepG2_Human1.12892353
80TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10342530
81NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10098887
82TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.09880600
83GABP_19822575_ChIP-Seq_HepG2_Human1.08355579
84DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.07676706
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07367059
86KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.07013876
87KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.07013876
88KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.07013876
89HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05886105
90ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05164620
91NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.04193532
92CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03772156
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.03422104
94SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00917014
95ESR2_21235772_ChIP-Seq_MCF-7_Human1.00415536
96ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98874080
97E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98734244
98TBX20_22328084_ChIP-Seq_HEART_Mouse0.96389233
99TBX20_22080862_ChIP-Seq_HEART_Mouse0.96389233
100SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93684220
101* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.92398797
102EP300_21415370_ChIP-Seq_HL-1_Mouse0.90799043
103NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89546535
104NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89546535
105PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89269224
106AUTS2_25519132_ChIP-Seq_293T-REX_Human0.88634180
107NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87060859
108STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.86318009
109GATA1_22025678_ChIP-Seq_K562_Human0.82595457
110CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.81207073
111GATA4_21415370_ChIP-Seq_HL-1_Mouse0.80938813
112MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.80681790
113ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.78977237
114BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77916725
115SOX2_27498859_Chip-Seq_STOMACH_Mouse0.76892269
116TRIM28_21343339_ChIP-Seq_HEK293_Human0.76215291
117GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.75492023
118TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73224186
119RXRA_24833708_ChIP-Seq_LIVER_Mouse0.72971204
120PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.72418076
121SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71600469
122* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.69126325
123ESR1_15608294_ChIP-ChIP_MCF-7_Human0.68502488
124PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.66256755
125ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.65534706
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.65185726
127AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.65105014
128OCT4_20526341_ChIP-Seq_ESCs_Human0.62916839
129STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.61601805
130EOMES_21245162_ChIP-Seq_HESCs_Human0.61118893
131PPAR_26484153_Chip-Seq_NCI-H1993_Human0.60361645
132SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.59470028
133GATA4_25053715_ChIP-Seq_YYC3_Human0.59005237
134DNAJC2_21179169_ChIP-ChIP_NT2_Human0.58904292
135SRF_21415370_ChIP-Seq_HL-1_Mouse0.58743258
136LXR_22292898_ChIP-Seq_THP-1_Human0.58521837
137PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.58087315
138SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.57580522
139NR3C1_23031785_ChIP-Seq_PC12_Mouse0.57263956
140* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.57156209
141POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.56899685
142CREB1_15753290_ChIP-ChIP_HEK293T_Human0.56748039
143RARA_24833708_ChIP-Seq_LIVER_Mouse0.55801082
144TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.55072042
145RAD21_21589869_ChIP-Seq_MESCs_Mouse0.54979665
146CBP_21632823_ChIP-Seq_H3396_Human0.53979432
147NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.53587892
148* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.53144032
149RACK7_27058665_Chip-Seq_MCF-7_Human0.53044608
150BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.52648401
151RARB_24833708_ChIP-Seq_LIVER_Mouse0.52092347
152ERG_21242973_ChIP-ChIP_JURKAT_Human0.51134503
153MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.50219376
154AR_20517297_ChIP-Seq_VCAP_Human0.49685323
155BCOR_27268052_Chip-Seq_Bcells_Human0.49326309
156ERG_20517297_ChIP-Seq_VCAP_Human0.47535220
157ZFP281_18757296_ChIP-ChIP_E14_Mouse0.47410976
158FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.47262732
159BCL6_27268052_Chip-Seq_Bcells_Human0.46907364
160FOXH1_21741376_ChIP-Seq_ESCs_Human0.46857034
161CTCF_27219007_Chip-Seq_Bcells_Human0.46409353
162PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.46109686
163CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.45910916
164GATA3_24758297_ChIP-Seq_MCF-7_Human0.45081683
165STAT3_1855785_ChIP-Seq_MESCs_Mouse0.44685795
166TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.44335462
167ATF3_27146783_Chip-Seq_COLON_Human0.44140975

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.72428279
2MP0005360_urolithiasis5.95578398
3MP0005365_abnormal_bile_salt4.92813777
4MP0005085_abnormal_gallbladder_physiolo4.80067081
5MP0008875_abnormal_xenobiotic_pharmacok3.65120828
6MP0003806_abnormal_nucleotide_metabolis3.59908933
7MP0002837_dystrophic_cardiac_calcinosis3.46172069
8MP0010329_abnormal_lipoprotein_level3.46032319
9MP0003941_abnormal_skin_development2.79994001
10MP0005332_abnormal_amino_acid2.75354010
11MP0009840_abnormal_foam_cell2.67279577
12MP0005670_abnormal_white_adipose2.63302153
13MP0004130_abnormal_muscle_cell2.60669253
14MP0003252_abnormal_bile_duct2.49012427
15MP0005623_abnormal_meninges_morphology2.48375204
16MP0003195_calcinosis2.29354435
17MP0005083_abnormal_biliary_tract2.29271719
18MP0002118_abnormal_lipid_homeostasis2.22311516
19MP0003646_muscle_fatigue2.18840337
20MP0010030_abnormal_orbit_morphology2.06420464
21MP0005666_abnormal_adipose_tissue2.00872961
22MP0008260_abnormal_autophagy1.88008599
23MP0000609_abnormal_liver_physiology1.84605595
24MP0000751_myopathy1.83025652
25MP0001666_abnormal_nutrient_absorption1.81071393
26MP0003191_abnormal_cellular_cholesterol1.80183400
27MP0008932_abnormal_embryonic_tissue1.76818148
28MP0008007_abnormal_cellular_replicative1.75748750
29MP0006036_abnormal_mitochondrial_physio1.73250108
30MP0005319_abnormal_enzyme/_coenzyme1.71758238
31MP0004957_abnormal_blastocyst_morpholog1.69416806
32MP0004019_abnormal_vitamin_homeostasis1.65027160
33MP0001346_abnormal_lacrimal_gland1.64540816
34MP0003111_abnormal_nucleus_morphology1.61598081
35MP0002971_abnormal_brown_adipose1.55579174
36MP0004084_abnormal_cardiac_muscle1.54582682
37MP0003705_abnormal_hypodermis_morpholog1.51037249
38MP0003186_abnormal_redox_activity1.50785902
39MP0005584_abnormal_enzyme/coenzyme_acti1.50771331
40MP0003011_delayed_dark_adaptation1.49452606
41MP0001764_abnormal_homeostasis1.49111661
42MP0000013_abnormal_adipose_tissue1.47847926
43MP0002638_abnormal_pupillary_reflex1.47534175
44MP0004036_abnormal_muscle_relaxation1.46062613
45MP0003693_abnormal_embryo_hatching1.44356034
46MP0002876_abnormal_thyroid_physiology1.44298582
47MP0004215_abnormal_myocardial_fiber1.40515199
48MP0005330_cardiomyopathy1.36927610
49MP0009697_abnormal_copulation1.36308066
50MP0005375_adipose_tissue_phenotype1.31285640
51MP0003566_abnormal_cell_adhesion1.30617667
52MP0004185_abnormal_adipocyte_glucose1.29357227
53MP0008438_abnormal_cutaneous_collagen1.28765093
54MP0006138_congestive_heart_failure1.26524995
55MP0000749_muscle_degeneration1.26095531
56MP0003077_abnormal_cell_cycle1.23947122
57MP0001661_extended_life_span1.23437628
58MP0005451_abnormal_body_composition1.22168180
59MP0001730_embryonic_growth_arrest1.21817914
60MP0005248_abnormal_Harderian_gland1.20397377
61MP0001727_abnormal_embryo_implantation1.18410798
62MP0009643_abnormal_urine_homeostasis1.18263532
63MP0001915_intracranial_hemorrhage1.16875637
64MP0004087_abnormal_muscle_fiber1.16135755
65MP0005535_abnormal_body_temperature1.15994710
66MP0002078_abnormal_glucose_homeostasis1.15381268
67MP0003656_abnormal_erythrocyte_physiolo1.13786176
68MP0005334_abnormal_fat_pad1.10097303
69MP0005620_abnormal_muscle_contractility1.09864376
70MP0002269_muscular_atrophy1.08923264
71MP0010094_abnormal_chromosome_stability1.08709167
72MP0003221_abnormal_cardiomyocyte_apopto1.07502624
73MP0002972_abnormal_cardiac_muscle1.05889891
74MP0005385_cardiovascular_system_phenoty1.02426645
75MP0001544_abnormal_cardiovascular_syste1.02426645
76MP0008775_abnormal_heart_ventricle1.01034266
77MP0004782_abnormal_surfactant_physiolog1.00621326
78MP0001299_abnormal_eye_distance/0.99288707
79MP0000747_muscle_weakness0.96914985
80MP0000598_abnormal_liver_morphology0.96414038
81MP0003329_amyloid_beta_deposits0.92779099
82MP0000003_abnormal_adipose_tissue0.92271088
83MP0002295_abnormal_pulmonary_circulatio0.92222909
84MP0005380_embryogenesis_phenotype0.91951854
85MP0001672_abnormal_embryogenesis/_devel0.91951854
86MP0001177_atelectasis0.90717181
87MP0005266_abnormal_metabolism0.90399169
88MP0000762_abnormal_tongue_morphology0.88408985
89MP0005448_abnormal_energy_balance0.87917169
90MP0002970_abnormal_white_adipose0.87012051
91MP0002090_abnormal_vision0.86674217
92MP0001756_abnormal_urination0.86188314
93MP0000750_abnormal_muscle_regeneration0.85171719
94MP0008058_abnormal_DNA_repair0.85030182
95MP0003984_embryonic_growth_retardation0.84793878
96MP0003690_abnormal_glial_cell0.82171624
97MP0009115_abnormal_fat_cell0.81856944
98MP0003385_abnormal_body_wall0.81651274
99MP0002088_abnormal_embryonic_growth/wei0.81417999
100MP0002080_prenatal_lethality0.81173978
101MP0003567_abnormal_fetal_cardiomyocyte0.79796599
102MP0005376_homeostasis/metabolism_phenot0.79408705
103MP0000604_amyloidosis0.79064485
104MP0000759_abnormal_skeletal_muscle0.78119812
105MP0000230_abnormal_systemic_arterial0.76924011
106MP0006035_abnormal_mitochondrial_morpho0.76820012
107MP0003868_abnormal_feces_composition0.76482149
108MP0009703_decreased_birth_body0.76073601
109MP0001529_abnormal_vocalization0.75512651
110MP0010368_abnormal_lymphatic_system0.74072492
111MP0010630_abnormal_cardiac_muscle0.73662114
112MP0009642_abnormal_blood_homeostasis0.73468546
113MP0002938_white_spotting0.72607178
114MP0002697_abnormal_eye_size0.72295492
115MP0003137_abnormal_impulse_conducting0.71083398
116MP0002106_abnormal_muscle_physiology0.70608661
117MP0005636_abnormal_mineral_homeostasis0.68991055
118MP0004043_abnormal_pH_regulation0.65961720
119MP0009780_abnormal_chondrocyte_physiolo0.63541372
120MP0009672_abnormal_birth_weight0.63196418
121MP0005084_abnormal_gallbladder_morpholo0.62433483
122MP0004233_abnormal_muscle_weight0.60780750
123MP0005452_abnormal_adipose_tissue0.60156546
124MP0003953_abnormal_hormone_level0.58927869
125MP0005275_abnormal_skin_tensile0.58865047
126MP0005369_muscle_phenotype0.58602741
127MP0003950_abnormal_plasma_membrane0.58013606
128MP0005408_hypopigmentation0.57670227
129MP0009763_increased_sensitivity_to0.55146404
130MP0002332_abnormal_exercise_endurance0.54513905
131MP0004085_abnormal_heartbeat0.53885082
132MP0005647_abnormal_sex_gland0.53119172
133MP0009384_cardiac_valve_regurgitation0.52145202
134MP0003959_abnormal_lean_body0.49144653
135MP0002138_abnormal_hepatobiliary_system0.48688509
136MP0004272_abnormal_basement_membrane0.47756191

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinuria (HP:0003108)5.04113270
2Hypobetalipoproteinemia (HP:0003563)4.98649380
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.90177931
4Deep venous thrombosis (HP:0002625)4.87717575
5Xanthomatosis (HP:0000991)4.67313525
6Abnormality of glycine metabolism (HP:0010895)4.63407381
7Abnormality of serine family amino acid metabolism (HP:0010894)4.63407381
8Intrahepatic cholestasis (HP:0001406)4.50709361
9Hyperammonemia (HP:0001987)4.39810037
10Ketosis (HP:0001946)4.36331431
11Hyperglycinemia (HP:0002154)4.36174193
12Hypolipoproteinemia (HP:0010981)4.17777987
13* Abnormality of fatty-acid metabolism (HP:0004359)4.17679025
14Hyperlipoproteinemia (HP:0010980)4.14029660
15Hypoglycemic coma (HP:0001325)4.05576548
16Abnormality of monocarboxylic acid metabolism (HP:0010996)4.04221960
17Cholecystitis (HP:0001082)3.91324208
18Abnormal gallbladder physiology (HP:0012438)3.91324208
19Hypoalphalipoproteinemia (HP:0003233)3.87142147
20Ketoacidosis (HP:0001993)3.80185093
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.78338891
22* Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.68396832
23Prolonged partial thromboplastin time (HP:0003645)3.57296635
24Myoglobinuria (HP:0002913)3.52629050
25Epidermoid cyst (HP:0200040)3.49520510
26Complement deficiency (HP:0004431)3.40863454
27Abnormality of glycolysis (HP:0004366)3.34596304
28Increased serum pyruvate (HP:0003542)3.34596304
29Nemaline bodies (HP:0003798)3.27521619
30Dicarboxylic aciduria (HP:0003215)3.25028909
31Abnormality of dicarboxylic acid metabolism (HP:0010995)3.25028909
32Cortical dysplasia (HP:0002539)3.23354338
33Abnormality of glutamine family amino acid metabolism (HP:0010902)3.17036453
34* Cholelithiasis (HP:0001081)3.07514581
35Cerebral edema (HP:0002181)3.03851162
36* Abnormal gallbladder morphology (HP:0012437)3.02974556
37Abnormality of serum amino acid levels (HP:0003112)2.98897034
38Muscle fiber inclusion bodies (HP:0100299)2.95678902
39Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.93933275
40Abnormality of aspartate family amino acid metabolism (HP:0010899)2.93208511
41Lethargy (HP:0001254)2.92422632
42Generalized aminoaciduria (HP:0002909)2.84302679
43Abnormality of sulfur amino acid metabolism (HP:0004339)2.76636660
44Hepatic necrosis (HP:0002605)2.76333240
45Gout (HP:0001997)2.76290685
46Vertebral compression fractures (HP:0002953)2.76082128
47Metabolic acidosis (HP:0001942)2.75751944
48Oligomenorrhea (HP:0000876)2.74923968
49Rhabdomyolysis (HP:0003201)2.73683290
50Exercise-induced myalgia (HP:0003738)2.72284242
51Abnormality of methionine metabolism (HP:0010901)2.67334666
52Muscle stiffness (HP:0003552)2.66173677
53Reduced antithrombin III activity (HP:0001976)2.62986847
54Abnormality of purine metabolism (HP:0004352)2.61455449
55* Hyperbilirubinemia (HP:0002904)2.59525370
56Back pain (HP:0003418)2.53500309
57Abnormality of the common coagulation pathway (HP:0010990)2.52373097
58Skin nodule (HP:0200036)2.51136185
59Exercise-induced muscle cramps (HP:0003710)2.50338489
60Fat malabsorption (HP:0002630)2.50014452
61Pheochromocytoma (HP:0002666)2.48626598
62Abnormality of nucleobase metabolism (HP:0010932)2.45807510
63Abnormality of the intrinsic pathway (HP:0010989)2.43795672
64Joint hemorrhage (HP:0005261)2.41757274
65Hypercholesterolemia (HP:0003124)2.41496644
66Acute encephalopathy (HP:0006846)2.39885652
67Abnormality of skeletal muscle fiber size (HP:0012084)2.39571056
68Centrally nucleated skeletal muscle fibers (HP:0003687)2.35592897
69Delayed CNS myelination (HP:0002188)2.34939663
70Fatigue (HP:0012378)2.33576602
71Pancreatic islet-cell hyperplasia (HP:0004510)2.31679425
72Vomiting (HP:0002013)2.31049124
73Palpitations (HP:0001962)2.28881386
74Neuroendocrine neoplasm (HP:0100634)2.27940612
75Increased purine levels (HP:0004368)2.25734282
76Hyperuricemia (HP:0002149)2.25734282
77* Abnormality of the gallbladder (HP:0005264)2.24116389
78Abnormality of complement system (HP:0005339)2.22821104
79Insidious onset (HP:0003587)2.22127652
80Termporal pattern (HP:0011008)2.22127652
81Nausea (HP:0002018)2.19152873
82Hypertriglyceridemia (HP:0002155)2.17569240
83Abnormality of pyrimidine metabolism (HP:0004353)2.14511633
84Increased variability in muscle fiber diameter (HP:0003557)2.13984698
85Retinal atrophy (HP:0001105)2.11428158
86Muscle fiber splitting (HP:0003555)2.10412263
87Hypokinesia (HP:0002375)2.05634383
88Neoplasm of the adrenal gland (HP:0100631)2.05459441
89Conjunctival hamartoma (HP:0100780)2.04782734
90Abnormal cartilage morphology (HP:0002763)2.04353837
91Hydroxyprolinuria (HP:0003080)2.04272916
92Abnormality of proline metabolism (HP:0010907)2.04272916
93Reticulocytosis (HP:0001923)2.03543064
94Sudden death (HP:0001699)2.03515914
95Increased muscle lipid content (HP:0009058)2.03242003
96Multiple enchondromatosis (HP:0005701)2.02930106
97Hepatocellular carcinoma (HP:0001402)2.02035396
98Protrusio acetabuli (HP:0003179)2.01907042
99Proximal tubulopathy (HP:0000114)2.01214434
100Hepatocellular necrosis (HP:0001404)1.99629181
101Neck muscle weakness (HP:0000467)1.99034000
102Irritability (HP:0000737)1.98641367
103Impaired pain sensation (HP:0007328)1.97641774
104Abnormality of pain sensation (HP:0010832)1.97641774
105Hyperglycemia (HP:0003074)1.95358784
106Spastic diplegia (HP:0001264)1.94556504
107Myocardial infarction (HP:0001658)1.94452229
108Abnormal mitochondria in muscle tissue (HP:0008316)1.94187890
109Sensorimotor neuropathy (HP:0007141)1.92760064
110Ragged-red muscle fibers (HP:0003200)1.91775415
111Late onset (HP:0003584)1.90949377
112Pancreatitis (HP:0001733)1.90744839
113Type 1 muscle fiber predominance (HP:0003803)1.90166729
114Lactic acidosis (HP:0003128)1.89421042
115Increased connective tissue (HP:0009025)1.89254855
116Progressive muscle weakness (HP:0003323)1.88283069
117Right ventricular cardiomyopathy (HP:0011663)1.88036432
118Neonatal onset (HP:0003623)1.87353290
119Hypoglycemic seizures (HP:0002173)1.86801037
120Abnormality of the umbilical cord (HP:0010881)1.86027694
121Steatorrhea (HP:0002570)1.85248480
122Conjugated hyperbilirubinemia (HP:0002908)1.84447449
123Methylmalonic aciduria (HP:0012120)1.82999411
124Abnormality of the fetal cardiovascular system (HP:0010948)1.79279385
125Abnormal umbilical cord blood vessels (HP:0011403)1.79279385
126Single umbilical artery (HP:0001195)1.79279385
127Lipoatrophy (HP:0100578)1.78706860
128Atrioventricular block (HP:0001678)1.78625693
129Generalized hypotonia (HP:0001290)1.77580673
130Acanthosis nigricans (HP:0000956)1.77149224
131Hyperinsulinemic hypoglycemia (HP:0000825)1.76091183
132Systemic lupus erythematosus (HP:0002725)1.75324465
133Dilated cardiomyopathy (HP:0001644)1.73777604
134Rimmed vacuoles (HP:0003805)1.73229763
135Abnormalities of placenta or umbilical cord (HP:0001194)1.66534514
136Vascular calcification (HP:0004934)1.66201950
137Myopathic facies (HP:0002058)1.64629645
138Glomerulonephritis (HP:0000099)1.63051035
139Premature rupture of membranes (HP:0001788)1.62726251
140Diminished movement (HP:0002374)1.61170937
141Beaking of vertebral bodies (HP:0004568)1.59958000
142Gowers sign (HP:0003391)1.59939982
143Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.59308286
144Abnormality of alanine metabolism (HP:0010916)1.59308286
145Hyperalaninemia (HP:0003348)1.59308286
146EMG: myopathic abnormalities (HP:0003458)1.55493735
147Cardiovascular calcification (HP:0011915)1.54912293

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.23052618
2TRIB33.87822408
3PDK43.39233255
4PDK33.39233255
5SIK13.37922383
6PBK3.10484283
7SRPK13.05682276
8BUB13.02585409
9TTK2.71704044
10PKN22.69000584
11TRIM282.55745440
12OBSCN2.32290722
13NEK12.29776132
14LMTK22.17752177
15FGFR42.13277838
16LIMK12.09451783
17MYLK1.97332565
18TTN1.90130465
19PINK11.87341320
20PAK41.86819547
21ERN11.85826955
22PHKG21.85598822
23PHKG11.85598822
24PRKD31.80841735
25EIF2AK31.77955798
26TESK21.75862029
27PDK21.75034613
28STK101.74492000
29PLK31.66310330
30ERBB41.47336937
31SCYL21.46720121
32BRSK11.46057047
33PTK2B1.39366458
34BCR1.38509213
35CDC71.36656474
36MAP4K21.31304043
37EEF2K1.30518266
38NTRK11.28347806
39SIK31.26848594
40CAMK1D1.25777792
41CDK81.21282662
42MAP2K41.16678463
43SGK2231.16360572
44SGK4941.16360572
45MST41.14001927
46NEK91.14000826
47FLT31.13856181
48INSRR1.13474724
49TESK11.12684462
50BRSK21.12301972
51MAP2K11.10233497
52STK38L1.07323932
53ALK1.05893403
54AKT21.04276019
55FGFR21.02357645
56DAPK21.01592233
57PLK11.01470922
58MAPK110.99064968
59PRPF4B0.98968495
60EPHA30.98606952
61CDK60.98534354
62PAK30.97236929
63PIK3CA0.97128062
64TIE10.96385140
65RIPK10.95447096
66CASK0.95327161
67WNK40.92779324
68LATS20.91350371
69PTK60.90543863
70SGK20.90084642
71SGK30.88392639
72PRKAA10.88322621
73PLK40.87480964
74PRKAA20.87065629
75MAP3K120.86276843
76YES10.85073675
77MET0.84777897
78AKT30.84533696
79MKNK10.83060502
80FRK0.82371252
81KSR10.80541412
82KSR20.79641784
83ERBB30.79290524
84EPHB20.78893508
85STK160.77842598
86VRK20.77632494
87AURKB0.77479799
88FGFR10.76503503
89RET0.75785542
90WEE10.74874127
91MST1R0.74832008
92PTK20.74213002
93ABL20.72390710
94PIK3CG0.71366033
95FER0.68020669
96MAP3K70.66592345
97EIF2AK10.65987033
98PRKACG0.65648297
99EPHA40.65289548
100MAP3K60.57687702
101KDR0.56669612
102LATS10.56612010
103PDPK10.56592257
104CSNK1G30.56077762
105DAPK30.55913895
106CDK140.55773099
107CDK180.55667651
108MINK10.55032339
109PAK20.53273234
110CCNB10.52987377
111OXSR10.52881189
112CSNK1G10.51956574
113MAP3K80.51529112
114ROCK20.51186432
115CDK190.50762728
116CDK150.50424777
117PDGFRA0.50335869
118STK390.50144491
119ILK0.49132351
120CSNK1A1L0.48543725
121ATR0.48397269
122ROCK10.48038558
123TSSK60.47419879
124CAMK2G0.46264360
125EIF2AK20.45724608
126STK40.45450794
127CDK11A0.44996690
128TAOK20.44635532
129PRKCZ0.43931895
130ATM0.43377106
131STK30.43238299
132MARK30.42615526
133BRAF0.42076677
134CDK70.42025231
135WNK30.41348335
136BMX0.40638464
137CSNK1G20.40605405
138MAP3K40.39330785
139MAPK40.38841451
140MAP2K60.38793536
141ICK0.38553637
142JAK20.37826593
143DAPK10.36158450
144DYRK20.35947387
145TGFBR10.35858541
146PRKD10.35530862
147CHEK10.35086784
148CLK10.35069437
149DDR20.34924650
150CSNK1E0.34728460
151NEK20.34352317
152CAMKK10.33846036
153CSNK2A10.33824312
154MUSK0.33243924
155PAK60.32715179
156PRKACB0.32479850
157ACVR1B0.32425369
158MAP3K50.32180983
159MAPK120.31957705
160EPHB10.30668604
161PRKCH0.30352822
162CDK40.29904547
163MAP2K70.29785672
164CAMK1G0.27916380
165ARAF0.27682392

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.22999624
2Propanoate metabolism_Homo sapiens_hsa006403.12514562
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.08710235
4Fatty acid degradation_Homo sapiens_hsa000713.05369830
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.05085663
6Primary bile acid biosynthesis_Homo sapiens_hsa001203.04253915
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.02950831
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.99299360
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.88704626
10Fatty acid metabolism_Homo sapiens_hsa012122.71385410
11Nitrogen metabolism_Homo sapiens_hsa009102.60469878
12Butanoate metabolism_Homo sapiens_hsa006502.52616620
13Arginine biosynthesis_Homo sapiens_hsa002202.44543327
14Tryptophan metabolism_Homo sapiens_hsa003802.35317545
15PPAR signaling pathway_Homo sapiens_hsa033202.24986753
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.24529060
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.17934180
18Fatty acid elongation_Homo sapiens_hsa000622.13298880
19Pyruvate metabolism_Homo sapiens_hsa006202.11680194
20Carbon metabolism_Homo sapiens_hsa012002.09718671
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.08864719
22* Peroxisome_Homo sapiens_hsa041462.04572448
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.86296919
24beta-Alanine metabolism_Homo sapiens_hsa004101.81159634
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.68261089
26Complement and coagulation cascades_Homo sapiens_hsa046101.61922706
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.61486468
28Biosynthesis of amino acids_Homo sapiens_hsa012301.57778723
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.51182199
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.49641389
31Phenylalanine metabolism_Homo sapiens_hsa003601.47601467
32Starch and sucrose metabolism_Homo sapiens_hsa005001.42312599
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.38579296
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.28917929
35Histidine metabolism_Homo sapiens_hsa003401.24549657
36Fatty acid biosynthesis_Homo sapiens_hsa000611.23884788
37Tyrosine metabolism_Homo sapiens_hsa003501.21298748
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.20817339
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.19831114
40Chemical carcinogenesis_Homo sapiens_hsa052041.19149794
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.18979417
42Sulfur metabolism_Homo sapiens_hsa009201.15437558
43Fat digestion and absorption_Homo sapiens_hsa049751.14088663
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.12790804
45Caffeine metabolism_Homo sapiens_hsa002321.12756701
46Selenocompound metabolism_Homo sapiens_hsa004501.08325393
47Retinol metabolism_Homo sapiens_hsa008301.08063976
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07455641
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06946739
50Vitamin B6 metabolism_Homo sapiens_hsa007501.05735221
51Bile secretion_Homo sapiens_hsa049761.03917973
52Steroid biosynthesis_Homo sapiens_hsa001001.00928982
53Glycerolipid metabolism_Homo sapiens_hsa005610.99915420
54Mismatch repair_Homo sapiens_hsa034300.99474969
55Arginine and proline metabolism_Homo sapiens_hsa003300.90379335
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89109099
57DNA replication_Homo sapiens_hsa030300.87490863
58Fructose and mannose metabolism_Homo sapiens_hsa000510.85041084
59Pentose phosphate pathway_Homo sapiens_hsa000300.83539835
60Staphylococcus aureus infection_Homo sapiens_hsa051500.83123515
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76846025
62Folate biosynthesis_Homo sapiens_hsa007900.74980385
63Non-homologous end-joining_Homo sapiens_hsa034500.68196889
64Base excision repair_Homo sapiens_hsa034100.67423490
65Galactose metabolism_Homo sapiens_hsa000520.66498190
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61870078
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59959068
68ABC transporters_Homo sapiens_hsa020100.59594477
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.56696290
70Vitamin digestion and absorption_Homo sapiens_hsa049770.56401040
71Lysine degradation_Homo sapiens_hsa003100.55515366
72Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54788561
73Metabolic pathways_Homo sapiens_hsa011000.51871991
74Sulfur relay system_Homo sapiens_hsa041220.51738294
75Glutathione metabolism_Homo sapiens_hsa004800.51650346
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.50808184
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49890987
78RNA transport_Homo sapiens_hsa030130.48267694
79Nucleotide excision repair_Homo sapiens_hsa034200.48086485
80Insulin resistance_Homo sapiens_hsa049310.47128909
81AMPK signaling pathway_Homo sapiens_hsa041520.46512359
82Oxidative phosphorylation_Homo sapiens_hsa001900.46460700
83Cell cycle_Homo sapiens_hsa041100.44639374
84Parkinsons disease_Homo sapiens_hsa050120.43703913
85Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43565629
86Glucagon signaling pathway_Homo sapiens_hsa049220.41218852
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.39047877
88Oocyte meiosis_Homo sapiens_hsa041140.34930535
89Vibrio cholerae infection_Homo sapiens_hsa051100.34311127
90Insulin signaling pathway_Homo sapiens_hsa049100.33871857
91Adherens junction_Homo sapiens_hsa045200.33691464
92Tight junction_Homo sapiens_hsa045300.33658729
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.29938023
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.27337180
95N-Glycan biosynthesis_Homo sapiens_hsa005100.25396717
96Cardiac muscle contraction_Homo sapiens_hsa042600.23473032
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.23164817
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.21807062
99Spliceosome_Homo sapiens_hsa030400.21304639
100Prion diseases_Homo sapiens_hsa050200.21005476
101Alzheimers disease_Homo sapiens_hsa050100.20203981
102Purine metabolism_Homo sapiens_hsa002300.19298937
103Thyroid cancer_Homo sapiens_hsa052160.19210769
104Other glycan degradation_Homo sapiens_hsa005110.17198427
105Pyrimidine metabolism_Homo sapiens_hsa002400.16618972
106RNA polymerase_Homo sapiens_hsa030200.14751960
107mRNA surveillance pathway_Homo sapiens_hsa030150.13492049
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.09929960
109Dilated cardiomyopathy_Homo sapiens_hsa054140.04351635
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.03989388
111Huntingtons disease_Homo sapiens_hsa050160.03642442
112Type II diabetes mellitus_Homo sapiens_hsa049300.03241800
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.02333802
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962-0.1211430
115HIF-1 signaling pathway_Homo sapiens_hsa04066-0.1150079
116Linoleic acid metabolism_Homo sapiens_hsa00591-0.0851074
117Proteasome_Homo sapiens_hsa03050-0.0801662
118Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0733525
119Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412-0.0628712
120Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0536905
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0439406
122One carbon pool by folate_Homo sapiens_hsa00670-0.0120294
123Regulation of autophagy_Homo sapiens_hsa04140-0.0022212

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