Rank | Gene Set | Z-score |
---|---|---|
1 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 5.76700780 |
2 | L-phenylalanine catabolic process (GO:0006559) | 5.76700780 |
3 | alpha-linolenic acid metabolic process (GO:0036109) | 5.66178503 |
4 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 5.54301602 |
5 | L-phenylalanine metabolic process (GO:0006558) | 5.54301602 |
6 | lysine metabolic process (GO:0006553) | 5.03802916 |
7 | lysine catabolic process (GO:0006554) | 5.03802916 |
8 | aromatic amino acid family catabolic process (GO:0009074) | 4.97766946 |
9 | glyoxylate metabolic process (GO:0046487) | 4.92004232 |
10 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 4.90908432 |
11 | fatty acid beta-oxidation (GO:0006635) | 4.65179723 |
12 | L-serine metabolic process (GO:0006563) | 4.65118284 |
13 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 4.64479983 |
14 | kynurenine metabolic process (GO:0070189) | 4.55835062 |
15 | 2-oxoglutarate metabolic process (GO:0006103) | 4.54065641 |
16 | acetyl-CoA metabolic process (GO:0006084) | 4.49629403 |
17 | regulation of triglyceride catabolic process (GO:0010896) | 4.39530709 |
18 | tryptophan catabolic process (GO:0006569) | 4.34515673 |
19 | indole-containing compound catabolic process (GO:0042436) | 4.34515673 |
20 | indolalkylamine catabolic process (GO:0046218) | 4.34515673 |
21 | bile acid biosynthetic process (GO:0006699) | 4.31392921 |
22 | cellular ketone body metabolic process (GO:0046950) | 4.29996166 |
23 | sulfur amino acid catabolic process (GO:0000098) | 4.29508646 |
24 | tricarboxylic acid cycle (GO:0006099) | 4.28037518 |
25 | fatty acid oxidation (GO:0019395) | 4.24704586 |
26 | amino-acid betaine metabolic process (GO:0006577) | 4.24699685 |
27 | fatty acid catabolic process (GO:0009062) | 4.21372514 |
28 | positive regulation of fatty acid beta-oxidation (GO:0032000) | 4.21230169 |
29 | biotin metabolic process (GO:0006768) | 4.19237851 |
30 | lipid oxidation (GO:0034440) | 4.18458296 |
31 | branched-chain amino acid catabolic process (GO:0009083) | 4.18449349 |
32 | fatty acid transmembrane transport (GO:1902001) | 4.17119386 |
33 | tryptophan metabolic process (GO:0006568) | 4.11194510 |
34 | aspartate family amino acid catabolic process (GO:0009068) | 4.09835524 |
35 | NADH metabolic process (GO:0006734) | 4.09660035 |
36 | valine metabolic process (GO:0006573) | 4.07861553 |
37 | serine family amino acid catabolic process (GO:0009071) | 4.06128623 |
38 | urea metabolic process (GO:0019627) | 4.05938866 |
39 | urea cycle (GO:0000050) | 4.05938866 |
40 | regulation of sequestering of triglyceride (GO:0010889) | 4.05488726 |
41 | cysteine metabolic process (GO:0006534) | 4.01874679 |
42 | COPI coating of Golgi vesicle (GO:0048205) | 4.01632449 |
43 | Golgi transport vesicle coating (GO:0048200) | 4.01632449 |
44 | negative regulation of fibrinolysis (GO:0051918) | 3.99929722 |
45 | monocarboxylic acid catabolic process (GO:0072329) | 3.98411008 |
46 | oxaloacetate metabolic process (GO:0006107) | 3.97174023 |
47 | alpha-amino acid catabolic process (GO:1901606) | 3.92888083 |
48 | complement activation, alternative pathway (GO:0006957) | 3.92219926 |
49 | plasma lipoprotein particle clearance (GO:0034381) | 3.91531804 |
50 | acylglycerol homeostasis (GO:0055090) | 3.90639986 |
51 | triglyceride homeostasis (GO:0070328) | 3.90639986 |
52 | carnitine shuttle (GO:0006853) | 3.86176312 |
53 | hexose biosynthetic process (GO:0019319) | 3.83903152 |
54 | positive regulation of fatty acid oxidation (GO:0046321) | 3.83793732 |
55 | branched-chain amino acid metabolic process (GO:0009081) | 3.83408815 |
56 | homocysteine metabolic process (GO:0050667) | 3.77762273 |
57 | gluconeogenesis (GO:0006094) | 3.77297484 |
58 | thioester biosynthetic process (GO:0035384) | 3.77119252 |
59 | acyl-CoA biosynthetic process (GO:0071616) | 3.77119252 |
60 | positive regulation of lipid catabolic process (GO:0050996) | 3.76095366 |
61 | high-density lipoprotein particle remodeling (GO:0034375) | 3.74026488 |
62 | short-chain fatty acid metabolic process (GO:0046459) | 3.73964832 |
63 | cellular amino acid catabolic process (GO:0009063) | 3.73886654 |
64 | nitrogen cycle metabolic process (GO:0071941) | 3.73101443 |
65 | ketone body metabolic process (GO:1902224) | 3.70998951 |
66 | bile acid metabolic process (GO:0008206) | 3.68918103 |
67 | regulation of fatty acid beta-oxidation (GO:0031998) | 3.65830605 |
68 | carnitine metabolic process (GO:0009437) | 3.65761310 |
69 | carboxylic acid catabolic process (GO:0046395) | 3.64625439 |
70 | organic acid catabolic process (GO:0016054) | 3.64625439 |
71 | monosaccharide biosynthetic process (GO:0046364) | 3.63753767 |
72 | tyrosine metabolic process (GO:0006570) | 3.63453322 |
73 | coenzyme catabolic process (GO:0009109) | 3.61194088 |
74 | aromatic amino acid family metabolic process (GO:0009072) | 3.59830237 |
75 | tricarboxylic acid metabolic process (GO:0072350) | 3.58023624 |
76 | regulation of protein activation cascade (GO:2000257) | 3.56641270 |
77 | peptidyl-glutamic acid carboxylation (GO:0017187) | 3.55602243 |
78 | protein carboxylation (GO:0018214) | 3.55602243 |
79 | fatty-acyl-CoA biosynthetic process (GO:0046949) | 3.55199835 |
80 | regulation of fibrinolysis (GO:0051917) | 3.54108892 |
81 | regulation of fatty acid oxidation (GO:0046320) | 3.53801261 |
82 | acyl-CoA metabolic process (GO:0006637) | 3.52199420 |
83 | thioester metabolic process (GO:0035383) | 3.52199420 |
84 | serine family amino acid biosynthetic process (GO:0009070) | 3.49984751 |
85 | low-density lipoprotein particle clearance (GO:0034383) | 3.49059479 |
86 | reverse cholesterol transport (GO:0043691) | 3.46852911 |
87 | regulation of cholesterol esterification (GO:0010872) | 3.43825682 |
88 | plasma lipoprotein particle remodeling (GO:0034369) | 3.43202409 |
89 | protein-lipid complex remodeling (GO:0034368) | 3.43202409 |
90 | macromolecular complex remodeling (GO:0034367) | 3.43202409 |
91 | triglyceride catabolic process (GO:0019433) | 3.42338400 |
92 | very long-chain fatty acid metabolic process (GO:0000038) | 3.42057142 |
93 | ethanol oxidation (GO:0006069) | 3.41556055 |
94 | succinate metabolic process (GO:0006105) | 3.40544041 |
95 | neutral lipid catabolic process (GO:0046461) | 3.36095136 |
96 | acylglycerol catabolic process (GO:0046464) | 3.36095136 |
97 | regulation of complement activation (GO:0030449) | 3.34689431 |
98 | coenzyme A metabolic process (GO:0015936) | 3.34153925 |
99 | fatty acid homeostasis (GO:0055089) | 3.33842115 |
100 | cellular modified amino acid catabolic process (GO:0042219) | 3.29667311 |
101 | glutamate metabolic process (GO:0006536) | 3.26766125 |
102 | glycine metabolic process (GO:0006544) | 3.26383116 |
103 | dicarboxylic acid biosynthetic process (GO:0043650) | 3.26336918 |
104 | fatty-acyl-CoA metabolic process (GO:0035337) | 3.26167080 |
105 | aldehyde catabolic process (GO:0046185) | 3.24007558 |
106 | serine family amino acid metabolic process (GO:0009069) | 3.21964461 |
107 | pyrimidine nucleobase catabolic process (GO:0006208) | 3.20791425 |
108 | establishment of integrated proviral latency (GO:0075713) | 3.15031667 |
109 | regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714) | 3.11931613 |
110 | protein complex localization (GO:0031503) | 3.01361976 |
111 | daunorubicin metabolic process (GO:0044597) | 3.00215881 |
112 | polyketide metabolic process (GO:0030638) | 3.00215881 |
113 | doxorubicin metabolic process (GO:0044598) | 3.00215881 |
114 | nucleotide-sugar biosynthetic process (GO:0009226) | 2.93992752 |
115 | IMP biosynthetic process (GO:0006188) | 2.92344961 |
116 | lipid particle organization (GO:0034389) | 2.88161978 |
117 | paraxial mesoderm development (GO:0048339) | 2.86256264 |
118 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 2.82980832 |
119 | NADPH regeneration (GO:0006740) | 2.82714402 |
120 | response to phenylpropanoid (GO:0080184) | 2.79570006 |
121 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 2.77939376 |
122 | oxidative phosphorylation (GO:0006119) | 2.75307094 |
123 | establishment of viral latency (GO:0019043) | 2.75076557 |
124 | protein maturation by protein folding (GO:0022417) | 2.74989700 |
125 | glycerolipid catabolic process (GO:0046503) | 2.74837736 |
126 | ethanol metabolic process (GO:0006067) | 2.71793192 |
127 | long-chain fatty-acyl-CoA metabolic process (GO:0035336) | 2.70545444 |
128 | cellular protein complex localization (GO:0034629) | 2.70219036 |
129 | IMP metabolic process (GO:0046040) | 2.69251499 |
130 | proline biosynthetic process (GO:0006561) | 2.68617031 |
131 | regulation of cofactor metabolic process (GO:0051193) | 2.68515130 |
132 | regulation of coenzyme metabolic process (GO:0051196) | 2.68515130 |
133 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 2.68341058 |
134 | negative regulation of ligase activity (GO:0051352) | 2.68341058 |
135 | coenzyme A biosynthetic process (GO:0015937) | 2.67633751 |
136 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 2.67182254 |
137 | acylglycerol biosynthetic process (GO:0046463) | 2.64822528 |
138 | neutral lipid biosynthetic process (GO:0046460) | 2.64822528 |
139 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 2.64336958 |
140 | triglyceride biosynthetic process (GO:0019432) | 2.63653592 |
141 | aminoglycoside antibiotic metabolic process (GO:0030647) | 2.63307373 |
142 | ribosome assembly (GO:0042255) | 2.62874226 |
143 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 2.62615619 |
144 | COPII vesicle coating (GO:0048208) | 2.60169092 |
145 | mitotic metaphase plate congression (GO:0007080) | 2.59591186 |
146 | long-chain fatty-acyl-CoA biosynthetic process (GO:0035338) | 2.58405460 |
147 | regulation of mitotic spindle organization (GO:0060236) | 2.56719292 |
148 | galactose catabolic process (GO:0019388) | 2.56323658 |
149 | purine nucleobase biosynthetic process (GO:0009113) | 2.55750940 |
150 | cholesterol biosynthetic process (GO:0006695) | 2.54518604 |
151 | glycolytic process (GO:0006096) | 2.53436415 |
152 | pyruvate metabolic process (GO:0006090) | 2.53135023 |
153 | diacylglycerol metabolic process (GO:0046339) | 2.51245529 |
154 | regulation of cellular amino acid metabolic process (GO:0006521) | 2.50240513 |
155 | glycogen catabolic process (GO:0005980) | 2.49063370 |
Rank | Gene Set | Z-score |
---|---|---|
1 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 9.82839126 |
2 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 9.14230594 |
3 | * RXR_22158963_ChIP-Seq_LIVER_Mouse | 6.89715557 |
4 | * PPARA_22158963_ChIP-Seq_LIVER_Mouse | 5.94726977 |
5 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 5.39735636 |
6 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 4.45075315 |
7 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 4.44729992 |
8 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 4.19580160 |
9 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 3.89720872 |
10 | E2F7_22180533_ChIP-Seq_HELA_Human | 3.50908033 |
11 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 3.50571485 |
12 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.35187019 |
13 | CLOCK_20551151_ChIP-Seq_293T_Human | 3.31760787 |
14 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.26746874 |
15 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.92668073 |
16 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 2.90243224 |
17 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.88911244 |
18 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.88713168 |
19 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.56515844 |
20 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 2.39119930 |
21 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.28624502 |
22 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.21807900 |
23 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.16039493 |
24 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.15378788 |
25 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.12707010 |
26 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 2.09255579 |
27 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.07560857 |
28 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.06392151 |
29 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.05182828 |
30 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 1.96021389 |
31 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.95913415 |
32 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.95691414 |
33 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.91075918 |
34 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 1.87972280 |
35 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.87476560 |
36 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.87128454 |
37 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.77045446 |
38 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.73216694 |
39 | * ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.72545334 |
40 | * E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.71101070 |
41 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 1.68989077 |
42 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.67521908 |
43 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.64962080 |
44 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.57233448 |
45 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 1.56570970 |
46 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.54847410 |
47 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.52644788 |
48 | * SOX17_20123909_ChIP-Seq_XEN_Mouse | 1.52258682 |
49 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.48145271 |
50 | * YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.45325290 |
51 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.44511598 |
52 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.42896939 |
53 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 1.36930681 |
54 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.34306720 |
55 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.33933848 |
56 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.33394928 |
57 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.31158564 |
58 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.29641737 |
59 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 1.28120606 |
60 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 1.27994524 |
61 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.27259007 |
62 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.25532754 |
63 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.25151041 |
64 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 1.23826497 |
65 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.22552864 |
66 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.22004014 |
67 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 1.21658557 |
68 | HTT_18923047_ChIP-ChIP_STHdh_Human | 1.19034698 |
69 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 1.18971844 |
70 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 1.18744821 |
71 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.18451360 |
72 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.16769951 |
73 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.16643825 |
74 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 1.16349859 |
75 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.15574120 |
76 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.15112699 |
77 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.13902491 |
78 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.13510116 |
79 | HNF4A_19822575_ChIP-Seq_HepG2_Human | 1.12892353 |
80 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.10342530 |
81 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.10098887 |
82 | TRIM28_19339689_ChIP-ChIP_MESCs_Mouse | 1.09880600 |
83 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.08355579 |
84 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.07676706 |
85 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.07367059 |
86 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.07013876 |
87 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.07013876 |
88 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.07013876 |
89 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.05886105 |
90 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.05164620 |
91 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 1.04193532 |
92 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.03772156 |
93 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.03422104 |
94 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.00917014 |
95 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.00415536 |
96 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 0.98874080 |
97 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 0.98734244 |
98 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 0.96389233 |
99 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 0.96389233 |
100 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.93684220 |
101 | * PPARG_20887899_ChIP-Seq_3T3-L1_Mouse | 0.92398797 |
102 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 0.90799043 |
103 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.89546535 |
104 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.89546535 |
105 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.89269224 |
106 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.88634180 |
107 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.87060859 |
108 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 0.86318009 |
109 | GATA1_22025678_ChIP-Seq_K562_Human | 0.82595457 |
110 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 0.81207073 |
111 | GATA4_21415370_ChIP-Seq_HL-1_Mouse | 0.80938813 |
112 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 0.80681790 |
113 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.78977237 |
114 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.77916725 |
115 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 0.76892269 |
116 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 0.76215291 |
117 | GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 0.75492023 |
118 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.73224186 |
119 | RXRA_24833708_ChIP-Seq_LIVER_Mouse | 0.72971204 |
120 | PPARG_20176806_ChIP-Seq_3T3-L1_Mouse | 0.72418076 |
121 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 0.71600469 |
122 | * NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 0.69126325 |
123 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.68502488 |
124 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.66256755 |
125 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 0.65534706 |
126 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.65185726 |
127 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.65105014 |
128 | OCT4_20526341_ChIP-Seq_ESCs_Human | 0.62916839 |
129 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 0.61601805 |
130 | EOMES_21245162_ChIP-Seq_HESCs_Human | 0.61118893 |
131 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 0.60361645 |
132 | SREBP2_21459322_ChIP-Seq_LIVER_Mouse | 0.59470028 |
133 | GATA4_25053715_ChIP-Seq_YYC3_Human | 0.59005237 |
134 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.58904292 |
135 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 0.58743258 |
136 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.58521837 |
137 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.58087315 |
138 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.57580522 |
139 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 0.57263956 |
140 | * TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.57156209 |
141 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.56899685 |
142 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 0.56748039 |
143 | RARA_24833708_ChIP-Seq_LIVER_Mouse | 0.55801082 |
144 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.55072042 |
145 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.54979665 |
146 | CBP_21632823_ChIP-Seq_H3396_Human | 0.53979432 |
147 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 0.53587892 |
148 | * SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.53144032 |
149 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.53044608 |
150 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.52648401 |
151 | RARB_24833708_ChIP-Seq_LIVER_Mouse | 0.52092347 |
152 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 0.51134503 |
153 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 0.50219376 |
154 | AR_20517297_ChIP-Seq_VCAP_Human | 0.49685323 |
155 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.49326309 |
156 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.47535220 |
157 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 0.47410976 |
158 | FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.47262732 |
159 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.46907364 |
160 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 0.46857034 |
161 | CTCF_27219007_Chip-Seq_Bcells_Human | 0.46409353 |
162 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.46109686 |
163 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.45910916 |
164 | GATA3_24758297_ChIP-Seq_MCF-7_Human | 0.45081683 |
165 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.44685795 |
166 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.44335462 |
167 | ATF3_27146783_Chip-Seq_COLON_Human | 0.44140975 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0002139_abnormal_hepatobiliary_system | 6.72428279 |
2 | MP0005360_urolithiasis | 5.95578398 |
3 | MP0005365_abnormal_bile_salt | 4.92813777 |
4 | MP0005085_abnormal_gallbladder_physiolo | 4.80067081 |
5 | MP0008875_abnormal_xenobiotic_pharmacok | 3.65120828 |
6 | MP0003806_abnormal_nucleotide_metabolis | 3.59908933 |
7 | MP0002837_dystrophic_cardiac_calcinosis | 3.46172069 |
8 | MP0010329_abnormal_lipoprotein_level | 3.46032319 |
9 | MP0003941_abnormal_skin_development | 2.79994001 |
10 | MP0005332_abnormal_amino_acid | 2.75354010 |
11 | MP0009840_abnormal_foam_cell | 2.67279577 |
12 | MP0005670_abnormal_white_adipose | 2.63302153 |
13 | MP0004130_abnormal_muscle_cell | 2.60669253 |
14 | MP0003252_abnormal_bile_duct | 2.49012427 |
15 | MP0005623_abnormal_meninges_morphology | 2.48375204 |
16 | MP0003195_calcinosis | 2.29354435 |
17 | MP0005083_abnormal_biliary_tract | 2.29271719 |
18 | MP0002118_abnormal_lipid_homeostasis | 2.22311516 |
19 | MP0003646_muscle_fatigue | 2.18840337 |
20 | MP0010030_abnormal_orbit_morphology | 2.06420464 |
21 | MP0005666_abnormal_adipose_tissue | 2.00872961 |
22 | MP0008260_abnormal_autophagy | 1.88008599 |
23 | MP0000609_abnormal_liver_physiology | 1.84605595 |
24 | MP0000751_myopathy | 1.83025652 |
25 | MP0001666_abnormal_nutrient_absorption | 1.81071393 |
26 | MP0003191_abnormal_cellular_cholesterol | 1.80183400 |
27 | MP0008932_abnormal_embryonic_tissue | 1.76818148 |
28 | MP0008007_abnormal_cellular_replicative | 1.75748750 |
29 | MP0006036_abnormal_mitochondrial_physio | 1.73250108 |
30 | MP0005319_abnormal_enzyme/_coenzyme | 1.71758238 |
31 | MP0004957_abnormal_blastocyst_morpholog | 1.69416806 |
32 | MP0004019_abnormal_vitamin_homeostasis | 1.65027160 |
33 | MP0001346_abnormal_lacrimal_gland | 1.64540816 |
34 | MP0003111_abnormal_nucleus_morphology | 1.61598081 |
35 | MP0002971_abnormal_brown_adipose | 1.55579174 |
36 | MP0004084_abnormal_cardiac_muscle | 1.54582682 |
37 | MP0003705_abnormal_hypodermis_morpholog | 1.51037249 |
38 | MP0003186_abnormal_redox_activity | 1.50785902 |
39 | MP0005584_abnormal_enzyme/coenzyme_acti | 1.50771331 |
40 | MP0003011_delayed_dark_adaptation | 1.49452606 |
41 | MP0001764_abnormal_homeostasis | 1.49111661 |
42 | MP0000013_abnormal_adipose_tissue | 1.47847926 |
43 | MP0002638_abnormal_pupillary_reflex | 1.47534175 |
44 | MP0004036_abnormal_muscle_relaxation | 1.46062613 |
45 | MP0003693_abnormal_embryo_hatching | 1.44356034 |
46 | MP0002876_abnormal_thyroid_physiology | 1.44298582 |
47 | MP0004215_abnormal_myocardial_fiber | 1.40515199 |
48 | MP0005330_cardiomyopathy | 1.36927610 |
49 | MP0009697_abnormal_copulation | 1.36308066 |
50 | MP0005375_adipose_tissue_phenotype | 1.31285640 |
51 | MP0003566_abnormal_cell_adhesion | 1.30617667 |
52 | MP0004185_abnormal_adipocyte_glucose | 1.29357227 |
53 | MP0008438_abnormal_cutaneous_collagen | 1.28765093 |
54 | MP0006138_congestive_heart_failure | 1.26524995 |
55 | MP0000749_muscle_degeneration | 1.26095531 |
56 | MP0003077_abnormal_cell_cycle | 1.23947122 |
57 | MP0001661_extended_life_span | 1.23437628 |
58 | MP0005451_abnormal_body_composition | 1.22168180 |
59 | MP0001730_embryonic_growth_arrest | 1.21817914 |
60 | MP0005248_abnormal_Harderian_gland | 1.20397377 |
61 | MP0001727_abnormal_embryo_implantation | 1.18410798 |
62 | MP0009643_abnormal_urine_homeostasis | 1.18263532 |
63 | MP0001915_intracranial_hemorrhage | 1.16875637 |
64 | MP0004087_abnormal_muscle_fiber | 1.16135755 |
65 | MP0005535_abnormal_body_temperature | 1.15994710 |
66 | MP0002078_abnormal_glucose_homeostasis | 1.15381268 |
67 | MP0003656_abnormal_erythrocyte_physiolo | 1.13786176 |
68 | MP0005334_abnormal_fat_pad | 1.10097303 |
69 | MP0005620_abnormal_muscle_contractility | 1.09864376 |
70 | MP0002269_muscular_atrophy | 1.08923264 |
71 | MP0010094_abnormal_chromosome_stability | 1.08709167 |
72 | MP0003221_abnormal_cardiomyocyte_apopto | 1.07502624 |
73 | MP0002972_abnormal_cardiac_muscle | 1.05889891 |
74 | MP0001544_abnormal_cardiovascular_syste | 1.02426645 |
75 | MP0005385_cardiovascular_system_phenoty | 1.02426645 |
76 | MP0008775_abnormal_heart_ventricle | 1.01034266 |
77 | MP0004782_abnormal_surfactant_physiolog | 1.00621326 |
78 | MP0001299_abnormal_eye_distance/ | 0.99288707 |
79 | MP0000747_muscle_weakness | 0.96914985 |
80 | MP0000598_abnormal_liver_morphology | 0.96414038 |
81 | MP0003329_amyloid_beta_deposits | 0.92779099 |
82 | MP0000003_abnormal_adipose_tissue | 0.92271088 |
83 | MP0002295_abnormal_pulmonary_circulatio | 0.92222909 |
84 | MP0001672_abnormal_embryogenesis/_devel | 0.91951854 |
85 | MP0005380_embryogenesis_phenotype | 0.91951854 |
86 | MP0001177_atelectasis | 0.90717181 |
87 | MP0005266_abnormal_metabolism | 0.90399169 |
88 | MP0000762_abnormal_tongue_morphology | 0.88408985 |
89 | MP0005448_abnormal_energy_balance | 0.87917169 |
90 | MP0002970_abnormal_white_adipose | 0.87012051 |
91 | MP0002090_abnormal_vision | 0.86674217 |
92 | MP0001756_abnormal_urination | 0.86188314 |
93 | MP0000750_abnormal_muscle_regeneration | 0.85171719 |
94 | MP0008058_abnormal_DNA_repair | 0.85030182 |
95 | MP0003984_embryonic_growth_retardation | 0.84793878 |
96 | MP0003690_abnormal_glial_cell | 0.82171624 |
97 | MP0009115_abnormal_fat_cell | 0.81856944 |
98 | MP0003385_abnormal_body_wall | 0.81651274 |
99 | MP0002088_abnormal_embryonic_growth/wei | 0.81417999 |
100 | MP0002080_prenatal_lethality | 0.81173978 |
101 | MP0003567_abnormal_fetal_cardiomyocyte | 0.79796599 |
102 | MP0005376_homeostasis/metabolism_phenot | 0.79408705 |
103 | MP0000604_amyloidosis | 0.79064485 |
104 | MP0000759_abnormal_skeletal_muscle | 0.78119812 |
105 | MP0000230_abnormal_systemic_arterial | 0.76924011 |
106 | MP0006035_abnormal_mitochondrial_morpho | 0.76820012 |
107 | MP0003868_abnormal_feces_composition | 0.76482149 |
108 | MP0009703_decreased_birth_body | 0.76073601 |
109 | MP0001529_abnormal_vocalization | 0.75512651 |
110 | MP0010368_abnormal_lymphatic_system | 0.74072492 |
111 | MP0010630_abnormal_cardiac_muscle | 0.73662114 |
112 | MP0009642_abnormal_blood_homeostasis | 0.73468546 |
113 | MP0002938_white_spotting | 0.72607178 |
114 | MP0002697_abnormal_eye_size | 0.72295492 |
115 | MP0003137_abnormal_impulse_conducting | 0.71083398 |
116 | MP0002106_abnormal_muscle_physiology | 0.70608661 |
117 | MP0005636_abnormal_mineral_homeostasis | 0.68991055 |
118 | MP0004043_abnormal_pH_regulation | 0.65961720 |
119 | MP0009780_abnormal_chondrocyte_physiolo | 0.63541372 |
120 | MP0009672_abnormal_birth_weight | 0.63196418 |
121 | MP0005084_abnormal_gallbladder_morpholo | 0.62433483 |
122 | MP0004233_abnormal_muscle_weight | 0.60780750 |
123 | MP0005452_abnormal_adipose_tissue | 0.60156546 |
124 | MP0003953_abnormal_hormone_level | 0.58927869 |
125 | MP0005275_abnormal_skin_tensile | 0.58865047 |
126 | MP0005369_muscle_phenotype | 0.58602741 |
127 | MP0003950_abnormal_plasma_membrane | 0.58013606 |
128 | MP0005408_hypopigmentation | 0.57670227 |
129 | MP0009763_increased_sensitivity_to | 0.55146404 |
130 | MP0002332_abnormal_exercise_endurance | 0.54513905 |
131 | MP0004085_abnormal_heartbeat | 0.53885082 |
132 | MP0005647_abnormal_sex_gland | 0.53119172 |
133 | MP0009384_cardiac_valve_regurgitation | 0.52145202 |
134 | MP0003959_abnormal_lean_body | 0.49144653 |
135 | MP0002138_abnormal_hepatobiliary_system | 0.48688509 |
136 | MP0004272_abnormal_basement_membrane | 0.47756191 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Hyperglycinuria (HP:0003108) | 5.04113270 |
2 | Hypobetalipoproteinemia (HP:0003563) | 4.98649380 |
3 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 4.90177931 |
4 | Deep venous thrombosis (HP:0002625) | 4.87717575 |
5 | Xanthomatosis (HP:0000991) | 4.67313525 |
6 | Abnormality of glycine metabolism (HP:0010895) | 4.63407381 |
7 | Abnormality of serine family amino acid metabolism (HP:0010894) | 4.63407381 |
8 | Intrahepatic cholestasis (HP:0001406) | 4.50709361 |
9 | Hyperammonemia (HP:0001987) | 4.39810037 |
10 | Ketosis (HP:0001946) | 4.36331431 |
11 | Hyperglycinemia (HP:0002154) | 4.36174193 |
12 | Hypolipoproteinemia (HP:0010981) | 4.17777987 |
13 | * Abnormality of fatty-acid metabolism (HP:0004359) | 4.17679025 |
14 | Hyperlipoproteinemia (HP:0010980) | 4.14029660 |
15 | Hypoglycemic coma (HP:0001325) | 4.05576548 |
16 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 4.04221960 |
17 | Cholecystitis (HP:0001082) | 3.91324208 |
18 | Abnormal gallbladder physiology (HP:0012438) | 3.91324208 |
19 | Hypoalphalipoproteinemia (HP:0003233) | 3.87142147 |
20 | Ketoacidosis (HP:0001993) | 3.80185093 |
21 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 3.78338891 |
22 | * Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 3.68396832 |
23 | Prolonged partial thromboplastin time (HP:0003645) | 3.57296635 |
24 | Myoglobinuria (HP:0002913) | 3.52629050 |
25 | Epidermoid cyst (HP:0200040) | 3.49520510 |
26 | Complement deficiency (HP:0004431) | 3.40863454 |
27 | Abnormality of glycolysis (HP:0004366) | 3.34596304 |
28 | Increased serum pyruvate (HP:0003542) | 3.34596304 |
29 | Nemaline bodies (HP:0003798) | 3.27521619 |
30 | Dicarboxylic aciduria (HP:0003215) | 3.25028909 |
31 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 3.25028909 |
32 | Cortical dysplasia (HP:0002539) | 3.23354338 |
33 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 3.17036453 |
34 | * Cholelithiasis (HP:0001081) | 3.07514581 |
35 | Cerebral edema (HP:0002181) | 3.03851162 |
36 | * Abnormal gallbladder morphology (HP:0012437) | 3.02974556 |
37 | Abnormality of serum amino acid levels (HP:0003112) | 2.98897034 |
38 | Muscle fiber inclusion bodies (HP:0100299) | 2.95678902 |
39 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 2.93933275 |
40 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.93208511 |
41 | Lethargy (HP:0001254) | 2.92422632 |
42 | Generalized aminoaciduria (HP:0002909) | 2.84302679 |
43 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 2.76636660 |
44 | Hepatic necrosis (HP:0002605) | 2.76333240 |
45 | Gout (HP:0001997) | 2.76290685 |
46 | Vertebral compression fractures (HP:0002953) | 2.76082128 |
47 | Metabolic acidosis (HP:0001942) | 2.75751944 |
48 | Oligomenorrhea (HP:0000876) | 2.74923968 |
49 | Rhabdomyolysis (HP:0003201) | 2.73683290 |
50 | Exercise-induced myalgia (HP:0003738) | 2.72284242 |
51 | Abnormality of methionine metabolism (HP:0010901) | 2.67334666 |
52 | Muscle stiffness (HP:0003552) | 2.66173677 |
53 | Reduced antithrombin III activity (HP:0001976) | 2.62986847 |
54 | Abnormality of purine metabolism (HP:0004352) | 2.61455449 |
55 | * Hyperbilirubinemia (HP:0002904) | 2.59525370 |
56 | Back pain (HP:0003418) | 2.53500309 |
57 | Abnormality of the common coagulation pathway (HP:0010990) | 2.52373097 |
58 | Skin nodule (HP:0200036) | 2.51136185 |
59 | Exercise-induced muscle cramps (HP:0003710) | 2.50338489 |
60 | Fat malabsorption (HP:0002630) | 2.50014452 |
61 | Pheochromocytoma (HP:0002666) | 2.48626598 |
62 | Abnormality of nucleobase metabolism (HP:0010932) | 2.45807510 |
63 | Abnormality of the intrinsic pathway (HP:0010989) | 2.43795672 |
64 | Joint hemorrhage (HP:0005261) | 2.41757274 |
65 | Hypercholesterolemia (HP:0003124) | 2.41496644 |
66 | Acute encephalopathy (HP:0006846) | 2.39885652 |
67 | Abnormality of skeletal muscle fiber size (HP:0012084) | 2.39571056 |
68 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 2.35592897 |
69 | Delayed CNS myelination (HP:0002188) | 2.34939663 |
70 | Fatigue (HP:0012378) | 2.33576602 |
71 | Pancreatic islet-cell hyperplasia (HP:0004510) | 2.31679425 |
72 | Vomiting (HP:0002013) | 2.31049124 |
73 | Palpitations (HP:0001962) | 2.28881386 |
74 | Neuroendocrine neoplasm (HP:0100634) | 2.27940612 |
75 | Increased purine levels (HP:0004368) | 2.25734282 |
76 | Hyperuricemia (HP:0002149) | 2.25734282 |
77 | * Abnormality of the gallbladder (HP:0005264) | 2.24116389 |
78 | Abnormality of complement system (HP:0005339) | 2.22821104 |
79 | Insidious onset (HP:0003587) | 2.22127652 |
80 | Termporal pattern (HP:0011008) | 2.22127652 |
81 | Nausea (HP:0002018) | 2.19152873 |
82 | Hypertriglyceridemia (HP:0002155) | 2.17569240 |
83 | Abnormality of pyrimidine metabolism (HP:0004353) | 2.14511633 |
84 | Increased variability in muscle fiber diameter (HP:0003557) | 2.13984698 |
85 | Retinal atrophy (HP:0001105) | 2.11428158 |
86 | Muscle fiber splitting (HP:0003555) | 2.10412263 |
87 | Hypokinesia (HP:0002375) | 2.05634383 |
88 | Neoplasm of the adrenal gland (HP:0100631) | 2.05459441 |
89 | Conjunctival hamartoma (HP:0100780) | 2.04782734 |
90 | Abnormal cartilage morphology (HP:0002763) | 2.04353837 |
91 | Hydroxyprolinuria (HP:0003080) | 2.04272916 |
92 | Abnormality of proline metabolism (HP:0010907) | 2.04272916 |
93 | Reticulocytosis (HP:0001923) | 2.03543064 |
94 | Sudden death (HP:0001699) | 2.03515914 |
95 | Increased muscle lipid content (HP:0009058) | 2.03242003 |
96 | Multiple enchondromatosis (HP:0005701) | 2.02930106 |
97 | Hepatocellular carcinoma (HP:0001402) | 2.02035396 |
98 | Protrusio acetabuli (HP:0003179) | 2.01907042 |
99 | Proximal tubulopathy (HP:0000114) | 2.01214434 |
100 | Hepatocellular necrosis (HP:0001404) | 1.99629181 |
101 | Neck muscle weakness (HP:0000467) | 1.99034000 |
102 | Irritability (HP:0000737) | 1.98641367 |
103 | Impaired pain sensation (HP:0007328) | 1.97641774 |
104 | Abnormality of pain sensation (HP:0010832) | 1.97641774 |
105 | Hyperglycemia (HP:0003074) | 1.95358784 |
106 | Spastic diplegia (HP:0001264) | 1.94556504 |
107 | Myocardial infarction (HP:0001658) | 1.94452229 |
108 | Abnormal mitochondria in muscle tissue (HP:0008316) | 1.94187890 |
109 | Sensorimotor neuropathy (HP:0007141) | 1.92760064 |
110 | Ragged-red muscle fibers (HP:0003200) | 1.91775415 |
111 | Late onset (HP:0003584) | 1.90949377 |
112 | Pancreatitis (HP:0001733) | 1.90744839 |
113 | Type 1 muscle fiber predominance (HP:0003803) | 1.90166729 |
114 | Lactic acidosis (HP:0003128) | 1.89421042 |
115 | Increased connective tissue (HP:0009025) | 1.89254855 |
116 | Progressive muscle weakness (HP:0003323) | 1.88283069 |
117 | Right ventricular cardiomyopathy (HP:0011663) | 1.88036432 |
118 | Neonatal onset (HP:0003623) | 1.87353290 |
119 | Hypoglycemic seizures (HP:0002173) | 1.86801037 |
120 | Abnormality of the umbilical cord (HP:0010881) | 1.86027694 |
121 | Steatorrhea (HP:0002570) | 1.85248480 |
122 | Conjugated hyperbilirubinemia (HP:0002908) | 1.84447449 |
123 | Methylmalonic aciduria (HP:0012120) | 1.82999411 |
124 | Abnormality of the fetal cardiovascular system (HP:0010948) | 1.79279385 |
125 | Abnormal umbilical cord blood vessels (HP:0011403) | 1.79279385 |
126 | Single umbilical artery (HP:0001195) | 1.79279385 |
127 | Lipoatrophy (HP:0100578) | 1.78706860 |
128 | Atrioventricular block (HP:0001678) | 1.78625693 |
129 | Generalized hypotonia (HP:0001290) | 1.77580673 |
130 | Acanthosis nigricans (HP:0000956) | 1.77149224 |
131 | Hyperinsulinemic hypoglycemia (HP:0000825) | 1.76091183 |
132 | Systemic lupus erythematosus (HP:0002725) | 1.75324465 |
133 | Dilated cardiomyopathy (HP:0001644) | 1.73777604 |
134 | Rimmed vacuoles (HP:0003805) | 1.73229763 |
135 | Abnormalities of placenta or umbilical cord (HP:0001194) | 1.66534514 |
136 | Vascular calcification (HP:0004934) | 1.66201950 |
137 | Myopathic facies (HP:0002058) | 1.64629645 |
138 | Glomerulonephritis (HP:0000099) | 1.63051035 |
139 | Premature rupture of membranes (HP:0001788) | 1.62726251 |
140 | Diminished movement (HP:0002374) | 1.61170937 |
141 | Beaking of vertebral bodies (HP:0004568) | 1.59958000 |
142 | Gowers sign (HP:0003391) | 1.59939982 |
143 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 1.59308286 |
144 | Abnormality of alanine metabolism (HP:0010916) | 1.59308286 |
145 | Hyperalaninemia (HP:0003348) | 1.59308286 |
146 | EMG: myopathic abnormalities (HP:0003458) | 1.55493735 |
147 | Cardiovascular calcification (HP:0011915) | 1.54912293 |
Rank | Gene Set | Z-score |
---|---|---|
1 | BCKDK | 6.23052618 |
2 | TRIB3 | 3.87822408 |
3 | PDK3 | 3.39233255 |
4 | PDK4 | 3.39233255 |
5 | SIK1 | 3.37922383 |
6 | PBK | 3.10484283 |
7 | SRPK1 | 3.05682276 |
8 | BUB1 | 3.02585409 |
9 | TTK | 2.71704044 |
10 | PKN2 | 2.69000584 |
11 | TRIM28 | 2.55745440 |
12 | OBSCN | 2.32290722 |
13 | NEK1 | 2.29776132 |
14 | LMTK2 | 2.17752177 |
15 | FGFR4 | 2.13277838 |
16 | LIMK1 | 2.09451783 |
17 | MYLK | 1.97332565 |
18 | TTN | 1.90130465 |
19 | PINK1 | 1.87341320 |
20 | PAK4 | 1.86819547 |
21 | ERN1 | 1.85826955 |
22 | PHKG2 | 1.85598822 |
23 | PHKG1 | 1.85598822 |
24 | PRKD3 | 1.80841735 |
25 | EIF2AK3 | 1.77955798 |
26 | TESK2 | 1.75862029 |
27 | PDK2 | 1.75034613 |
28 | STK10 | 1.74492000 |
29 | PLK3 | 1.66310330 |
30 | ERBB4 | 1.47336937 |
31 | SCYL2 | 1.46720121 |
32 | BRSK1 | 1.46057047 |
33 | PTK2B | 1.39366458 |
34 | BCR | 1.38509213 |
35 | CDC7 | 1.36656474 |
36 | MAP4K2 | 1.31304043 |
37 | EEF2K | 1.30518266 |
38 | NTRK1 | 1.28347806 |
39 | SIK3 | 1.26848594 |
40 | CAMK1D | 1.25777792 |
41 | CDK8 | 1.21282662 |
42 | MAP2K4 | 1.16678463 |
43 | SGK494 | 1.16360572 |
44 | SGK223 | 1.16360572 |
45 | MST4 | 1.14001927 |
46 | NEK9 | 1.14000826 |
47 | FLT3 | 1.13856181 |
48 | INSRR | 1.13474724 |
49 | TESK1 | 1.12684462 |
50 | BRSK2 | 1.12301972 |
51 | MAP2K1 | 1.10233497 |
52 | STK38L | 1.07323932 |
53 | ALK | 1.05893403 |
54 | AKT2 | 1.04276019 |
55 | FGFR2 | 1.02357645 |
56 | DAPK2 | 1.01592233 |
57 | PLK1 | 1.01470922 |
58 | MAPK11 | 0.99064968 |
59 | PRPF4B | 0.98968495 |
60 | EPHA3 | 0.98606952 |
61 | CDK6 | 0.98534354 |
62 | PAK3 | 0.97236929 |
63 | PIK3CA | 0.97128062 |
64 | TIE1 | 0.96385140 |
65 | RIPK1 | 0.95447096 |
66 | CASK | 0.95327161 |
67 | WNK4 | 0.92779324 |
68 | LATS2 | 0.91350371 |
69 | PTK6 | 0.90543863 |
70 | SGK2 | 0.90084642 |
71 | SGK3 | 0.88392639 |
72 | PRKAA1 | 0.88322621 |
73 | PLK4 | 0.87480964 |
74 | PRKAA2 | 0.87065629 |
75 | MAP3K12 | 0.86276843 |
76 | YES1 | 0.85073675 |
77 | MET | 0.84777897 |
78 | AKT3 | 0.84533696 |
79 | MKNK1 | 0.83060502 |
80 | FRK | 0.82371252 |
81 | KSR1 | 0.80541412 |
82 | KSR2 | 0.79641784 |
83 | ERBB3 | 0.79290524 |
84 | EPHB2 | 0.78893508 |
85 | STK16 | 0.77842598 |
86 | VRK2 | 0.77632494 |
87 | AURKB | 0.77479799 |
88 | FGFR1 | 0.76503503 |
89 | RET | 0.75785542 |
90 | WEE1 | 0.74874127 |
91 | MST1R | 0.74832008 |
92 | PTK2 | 0.74213002 |
93 | ABL2 | 0.72390710 |
94 | PIK3CG | 0.71366033 |
95 | FER | 0.68020669 |
96 | MAP3K7 | 0.66592345 |
97 | EIF2AK1 | 0.65987033 |
98 | PRKACG | 0.65648297 |
99 | EPHA4 | 0.65289548 |
100 | MAP3K6 | 0.57687702 |
101 | KDR | 0.56669612 |
102 | LATS1 | 0.56612010 |
103 | PDPK1 | 0.56592257 |
104 | CSNK1G3 | 0.56077762 |
105 | DAPK3 | 0.55913895 |
106 | CDK14 | 0.55773099 |
107 | CDK18 | 0.55667651 |
108 | MINK1 | 0.55032339 |
109 | PAK2 | 0.53273234 |
110 | CCNB1 | 0.52987377 |
111 | OXSR1 | 0.52881189 |
112 | CSNK1G1 | 0.51956574 |
113 | MAP3K8 | 0.51529112 |
114 | ROCK2 | 0.51186432 |
115 | CDK19 | 0.50762728 |
116 | CDK15 | 0.50424777 |
117 | PDGFRA | 0.50335869 |
118 | STK39 | 0.50144491 |
119 | ILK | 0.49132351 |
120 | CSNK1A1L | 0.48543725 |
121 | ATR | 0.48397269 |
122 | ROCK1 | 0.48038558 |
123 | TSSK6 | 0.47419879 |
124 | CAMK2G | 0.46264360 |
125 | EIF2AK2 | 0.45724608 |
126 | STK4 | 0.45450794 |
127 | CDK11A | 0.44996690 |
128 | TAOK2 | 0.44635532 |
129 | PRKCZ | 0.43931895 |
130 | ATM | 0.43377106 |
131 | STK3 | 0.43238299 |
132 | MARK3 | 0.42615526 |
133 | BRAF | 0.42076677 |
134 | CDK7 | 0.42025231 |
135 | WNK3 | 0.41348335 |
136 | BMX | 0.40638464 |
137 | CSNK1G2 | 0.40605405 |
138 | MAP3K4 | 0.39330785 |
139 | MAPK4 | 0.38841451 |
140 | MAP2K6 | 0.38793536 |
141 | ICK | 0.38553637 |
142 | JAK2 | 0.37826593 |
143 | DAPK1 | 0.36158450 |
144 | DYRK2 | 0.35947387 |
145 | TGFBR1 | 0.35858541 |
146 | PRKD1 | 0.35530862 |
147 | CHEK1 | 0.35086784 |
148 | CLK1 | 0.35069437 |
149 | DDR2 | 0.34924650 |
150 | CSNK1E | 0.34728460 |
151 | NEK2 | 0.34352317 |
152 | CAMKK1 | 0.33846036 |
153 | CSNK2A1 | 0.33824312 |
154 | MUSK | 0.33243924 |
155 | PAK6 | 0.32715179 |
156 | PRKACB | 0.32479850 |
157 | ACVR1B | 0.32425369 |
158 | MAP3K5 | 0.32180983 |
159 | MAPK12 | 0.31957705 |
160 | EPHB1 | 0.30668604 |
161 | PRKCH | 0.30352822 |
162 | CDK4 | 0.29904547 |
163 | MAP2K7 | 0.29785672 |
164 | CAMK1G | 0.27916380 |
165 | ARAF | 0.27682392 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 3.22999624 |
2 | Propanoate metabolism_Homo sapiens_hsa00640 | 3.12514562 |
3 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 3.08710235 |
4 | Fatty acid degradation_Homo sapiens_hsa00071 | 3.05369830 |
5 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 3.05085663 |
6 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 3.04253915 |
7 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 3.02950831 |
8 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 2.99299360 |
9 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 2.88704626 |
10 | Fatty acid metabolism_Homo sapiens_hsa01212 | 2.71385410 |
11 | Nitrogen metabolism_Homo sapiens_hsa00910 | 2.60469878 |
12 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.52616620 |
13 | Arginine biosynthesis_Homo sapiens_hsa00220 | 2.44543327 |
14 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.35317545 |
15 | PPAR signaling pathway_Homo sapiens_hsa03320 | 2.24986753 |
16 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 2.24529060 |
17 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.17934180 |
18 | Fatty acid elongation_Homo sapiens_hsa00062 | 2.13298880 |
19 | Pyruvate metabolism_Homo sapiens_hsa00620 | 2.11680194 |
20 | Carbon metabolism_Homo sapiens_hsa01200 | 2.09718671 |
21 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 2.08864719 |
22 | * Peroxisome_Homo sapiens_hsa04146 | 2.04572448 |
23 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 1.86296919 |
24 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.81159634 |
25 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.68261089 |
26 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 1.61922706 |
27 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.61486468 |
28 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.57778723 |
29 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.51182199 |
30 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.49641389 |
31 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.47601467 |
32 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.42312599 |
33 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.38579296 |
34 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.28917929 |
35 | Histidine metabolism_Homo sapiens_hsa00340 | 1.24549657 |
36 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 1.23884788 |
37 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.21298748 |
38 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.20817339 |
39 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.19831114 |
40 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.19149794 |
41 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.18979417 |
42 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.15437558 |
43 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.14088663 |
44 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.12790804 |
45 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.12756701 |
46 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.08325393 |
47 | Retinol metabolism_Homo sapiens_hsa00830 | 1.08063976 |
48 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.07455641 |
49 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.06946739 |
50 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.05735221 |
51 | Bile secretion_Homo sapiens_hsa04976 | 1.03917973 |
52 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.00928982 |
53 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.99915420 |
54 | Mismatch repair_Homo sapiens_hsa03430 | 0.99474969 |
55 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.90379335 |
56 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.89109099 |
57 | DNA replication_Homo sapiens_hsa03030 | 0.87490863 |
58 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.85041084 |
59 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.83539835 |
60 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.83123515 |
61 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.76846025 |
62 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.74980385 |
63 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.68196889 |
64 | Base excision repair_Homo sapiens_hsa03410 | 0.67423490 |
65 | Galactose metabolism_Homo sapiens_hsa00052 | 0.66498190 |
66 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.61870078 |
67 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.59959068 |
68 | ABC transporters_Homo sapiens_hsa02010 | 0.59594477 |
69 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.56696290 |
70 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.56401040 |
71 | Lysine degradation_Homo sapiens_hsa00310 | 0.55515366 |
72 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.54788561 |
73 | Metabolic pathways_Homo sapiens_hsa01100 | 0.51871991 |
74 | Sulfur relay system_Homo sapiens_hsa04122 | 0.51738294 |
75 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.51650346 |
76 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.50808184 |
77 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.49890987 |
78 | RNA transport_Homo sapiens_hsa03013 | 0.48267694 |
79 | Nucleotide excision repair_Homo sapiens_hsa03420 | 0.48086485 |
80 | Insulin resistance_Homo sapiens_hsa04931 | 0.47128909 |
81 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.46512359 |
82 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.46460700 |
83 | Cell cycle_Homo sapiens_hsa04110 | 0.44639374 |
84 | Parkinsons disease_Homo sapiens_hsa05012 | 0.43703913 |
85 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 0.43565629 |
86 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.41218852 |
87 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.39047877 |
88 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.34930535 |
89 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.34311127 |
90 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.33871857 |
91 | Adherens junction_Homo sapiens_hsa04520 | 0.33691464 |
92 | Tight junction_Homo sapiens_hsa04530 | 0.33658729 |
93 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.29938023 |
94 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.27337180 |
95 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.25396717 |
96 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.23473032 |
97 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.23164817 |
98 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.21807062 |
99 | Spliceosome_Homo sapiens_hsa03040 | 0.21304639 |
100 | Prion diseases_Homo sapiens_hsa05020 | 0.21005476 |
101 | Alzheimers disease_Homo sapiens_hsa05010 | 0.20203981 |
102 | Purine metabolism_Homo sapiens_hsa00230 | 0.19298937 |
103 | Thyroid cancer_Homo sapiens_hsa05216 | 0.19210769 |
104 | Other glycan degradation_Homo sapiens_hsa00511 | 0.17198427 |
105 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 0.16618972 |
106 | RNA polymerase_Homo sapiens_hsa03020 | 0.14751960 |
107 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.13492049 |
108 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.09929960 |
109 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.04351635 |
110 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.03989388 |
111 | Huntingtons disease_Homo sapiens_hsa05016 | 0.03642442 |
112 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.03241800 |
113 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.02333802 |
114 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | -0.1211430 |
115 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | -0.1150079 |
116 | Linoleic acid metabolism_Homo sapiens_hsa00591 | -0.0851074 |
117 | Proteasome_Homo sapiens_hsa03050 | -0.0801662 |
118 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | -0.0733525 |
119 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | -0.0628712 |
120 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | -0.0536905 |
121 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | -0.0439406 |
122 | One carbon pool by folate_Homo sapiens_hsa00670 | -0.0120294 |
123 | Regulation of autophagy_Homo sapiens_hsa04140 | -0.0022212 |