PEX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an integral peroxisomal membrane protein required for peroxisome biogenesis. The protein is thought to be involved in peroxisomal matrix protein import. Mutations in this gene result in one form of Zellweger syndrome and infantile Refsum disease. Alternative splicing results in multiple transcript variants encoding the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)7.42531752
2axon ensheathment in central nervous system (GO:0032291)7.42531752
3fatty acid elongation (GO:0030497)6.91619470
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.59415291
5L-phenylalanine catabolic process (GO:0006559)5.59415291
6cholesterol biosynthetic process (GO:0006695)5.03471514
7L-phenylalanine metabolic process (GO:0006558)4.99635414
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.99635414
9nucleotide transmembrane transport (GO:1901679)4.66268133
10aldehyde catabolic process (GO:0046185)4.59459268
11sterol biosynthetic process (GO:0016126)4.40537817
12epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.23175189
13epithelial cilium movement (GO:0003351)4.22151173
14long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.10324976
15aromatic amino acid family catabolic process (GO:0009074)4.06025823
16glyoxylate metabolic process (GO:0046487)4.04670146
17* very long-chain fatty acid metabolic process (GO:0000038)3.93356849
18fatty-acyl-CoA biosynthetic process (GO:0046949)3.85494352
19signal peptide processing (GO:0006465)3.84145775
20myelination (GO:0042552)3.79510883
21ensheathment of neurons (GO:0007272)3.79428831
22axon ensheathment (GO:0008366)3.79428831
23intraciliary transport (GO:0042073)3.74069613
24fatty-acyl-CoA metabolic process (GO:0035337)3.71331552
25respiratory chain complex IV assembly (GO:0008535)3.69609579
26DNA double-strand break processing (GO:0000729)3.69454893
27heme transport (GO:0015886)3.65422229
28positive regulation of cellular amine metabolic process (GO:0033240)3.63259648
29mitochondrial respiratory chain complex I assembly (GO:0032981)3.61107274
30NADH dehydrogenase complex assembly (GO:0010257)3.61107274
31mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.61107274
32long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.61074806
33nonmotile primary cilium assembly (GO:0035058)3.59743903
34cofactor catabolic process (GO:0051187)3.56916887
35cilium movement (GO:0003341)3.56070196
36regulation of cilium movement (GO:0003352)3.52336576
37isoprenoid biosynthetic process (GO:0008299)3.52086177
38protein complex biogenesis (GO:0070271)3.48871831
39L-serine metabolic process (GO:0006563)3.48751523
40thioester biosynthetic process (GO:0035384)3.47279807
41acyl-CoA biosynthetic process (GO:0071616)3.47279807
42cullin deneddylation (GO:0010388)3.44725043
43proteasome assembly (GO:0043248)3.44553722
44nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.41784060
45purine ribonucleotide transport (GO:0015868)3.41317188
46platelet dense granule organization (GO:0060155)3.41232942
47response to methylmercury (GO:0051597)3.38051784
48mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.37542068
49nucleotide transport (GO:0006862)3.37457833
50establishment of protein localization to mitochondrial membrane (GO:0090151)3.37251157
51behavioral response to nicotine (GO:0035095)3.35403623
52mitochondrial respiratory chain complex assembly (GO:0033108)3.34832496
53response to redox state (GO:0051775)3.32561247
54alpha-linolenic acid metabolic process (GO:0036109)3.32197689
55cilium morphogenesis (GO:0060271)3.31306319
56exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.30378969
57mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.29359514
58thioester metabolic process (GO:0035383)3.29149768
59acyl-CoA metabolic process (GO:0006637)3.29149768
60long-chain fatty acid biosynthetic process (GO:0042759)3.28710011
61* bile acid biosynthetic process (GO:0006699)3.28587580
62centriole replication (GO:0007099)3.27570137
63myelin maintenance (GO:0043217)3.21614375
64protein K6-linked ubiquitination (GO:0085020)3.21208185
65water-soluble vitamin biosynthetic process (GO:0042364)3.16609927
66short-chain fatty acid metabolic process (GO:0046459)3.16176434
67coenzyme catabolic process (GO:0009109)3.15345434
68cellular ketone body metabolic process (GO:0046950)3.14530527
69resolution of meiotic recombination intermediates (GO:0000712)3.11535653
70ribosomal large subunit biogenesis (GO:0042273)3.11222665
71detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.10369671
72ATP synthesis coupled proton transport (GO:0015986)3.08861844
73energy coupled proton transport, down electrochemical gradient (GO:0015985)3.08861844
74amyloid precursor protein catabolic process (GO:0042987)3.08367734
75serine family amino acid biosynthetic process (GO:0009070)3.07288043
76ethanol metabolic process (GO:0006067)3.04570997
77response to pheromone (GO:0019236)3.04402290
78tyrosine metabolic process (GO:0006570)3.03115749
79cilium organization (GO:0044782)3.02943630
80DNA deamination (GO:0045006)3.02843071
81ribosomal small subunit assembly (GO:0000028)3.02481476
82branched-chain amino acid catabolic process (GO:0009083)3.02278971
83amyloid precursor protein metabolic process (GO:0042982)3.01492564
84piRNA metabolic process (GO:0034587)3.00483469
85regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.00365386
86opsonization (GO:0008228)2.98771665
87chromatin remodeling at centromere (GO:0031055)2.98697835
88glutathione derivative biosynthetic process (GO:1901687)2.98614018
89glutathione derivative metabolic process (GO:1901685)2.98614018
90anterograde synaptic vesicle transport (GO:0048490)2.97761997
91pyrimidine-containing compound transmembrane transport (GO:0072531)2.97127689
92cilium assembly (GO:0042384)2.96755240
93creatine metabolic process (GO:0006600)2.95347742
94purine nucleotide transport (GO:0015865)2.95313636
95protein neddylation (GO:0045116)2.94561664
96protein deneddylation (GO:0000338)2.93965673
97neuron fate determination (GO:0048664)2.93373464
98peptidyl-histidine modification (GO:0018202)2.93303904
99oligodendrocyte differentiation (GO:0048709)2.92628987
100* steroid biosynthetic process (GO:0006694)2.92064219
101inositol phosphate catabolic process (GO:0071545)2.91426140
102protein localization to cilium (GO:0061512)2.91209890
103respiratory electron transport chain (GO:0022904)2.90584319
104substantia nigra development (GO:0021762)2.89672294
105cytochrome complex assembly (GO:0017004)2.89023231
106CENP-A containing nucleosome assembly (GO:0034080)2.88097063
107triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.87874924
108photoreceptor cell maintenance (GO:0045494)2.87777301
109axoneme assembly (GO:0035082)2.85755431
110regulation of glucokinase activity (GO:0033131)2.85693681
111regulation of hexokinase activity (GO:1903299)2.85693681
112ethanol oxidation (GO:0006069)2.84830496
113aromatic amino acid family metabolic process (GO:0009072)2.84747378
114preassembly of GPI anchor in ER membrane (GO:0016254)2.84031175
115phosphorylated carbohydrate dephosphorylation (GO:0046838)2.83001324
116inositol phosphate dephosphorylation (GO:0046855)2.83001324
117replication fork processing (GO:0031297)2.82718455
118negative regulation of neurotransmitter secretion (GO:0046929)2.82055101
119primary alcohol catabolic process (GO:0034310)2.81659131
120RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.81483069
121tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.81483069
122electron transport chain (GO:0022900)2.81320083
123import into cell (GO:0098657)2.80694291
124organelle disassembly (GO:1903008)2.79794632
125cellular aldehyde metabolic process (GO:0006081)2.78941462
126ketone body metabolic process (GO:1902224)2.78543332
127tryptophan catabolic process (GO:0006569)2.78121039
128indole-containing compound catabolic process (GO:0042436)2.78121039
129indolalkylamine catabolic process (GO:0046218)2.78121039
130cysteine metabolic process (GO:0006534)2.78090007
131low-density lipoprotein particle remodeling (GO:0034374)2.77197556
132protein-cofactor linkage (GO:0018065)2.77120636
133glutathione metabolic process (GO:0006749)2.75747500
134glycerophospholipid catabolic process (GO:0046475)2.75293948
135somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.75111840
136isotype switching (GO:0045190)2.75111840
137somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.75111840
138GPI anchor biosynthetic process (GO:0006506)2.75058277
139ubiquinone biosynthetic process (GO:0006744)2.73850003
140regulation of lipoprotein metabolic process (GO:0050746)2.73591625
141regulation of cholesterol esterification (GO:0010872)2.72563512
142ubiquinone metabolic process (GO:0006743)2.72546925
143mannosylation (GO:0097502)2.72108807
144cotranslational protein targeting to membrane (GO:0006613)2.72101429
145somatic hypermutation of immunoglobulin genes (GO:0016446)2.71699082
146somatic diversification of immune receptors via somatic mutation (GO:0002566)2.71699082
147cholesterol metabolic process (GO:0008203)2.70900569
148SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.70036939
149sulfur amino acid catabolic process (GO:0000098)2.69604200
150negative regulation of protein localization to cell surface (GO:2000009)2.69312301
151* bile acid metabolic process (GO:0008206)2.69170377
152amino acid salvage (GO:0043102)2.67859840
153L-methionine salvage (GO:0071267)2.67859840
154L-methionine biosynthetic process (GO:0071265)2.67859840
155protein carboxylation (GO:0018214)2.67343493
156peptidyl-glutamic acid carboxylation (GO:0017187)2.67343493
157iron coordination entity transport (GO:1901678)2.67258288
158tryptophan metabolic process (GO:0006568)2.67168470
159estrogen biosynthetic process (GO:0006703)2.65416238
160positive regulation of mitochondrial fission (GO:0090141)2.65102549
161carbohydrate derivative transport (GO:1901264)2.65022517
162eye photoreceptor cell differentiation (GO:0001754)2.64948598
163photoreceptor cell differentiation (GO:0046530)2.64948598
164GPI anchor metabolic process (GO:0006505)2.64750700
165ribonucleoprotein complex disassembly (GO:0032988)2.64681536
166response to nitrosative stress (GO:0051409)2.64165058
167protein targeting to ER (GO:0045047)2.61549208
168recombinational repair (GO:0000725)2.59166566
169RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.58991510
170neural tube formation (GO:0001841)2.58252493
171establishment of protein localization to endoplasmic reticulum (GO:0072599)2.57356975
172kinetochore organization (GO:0051383)2.56671967
173DNA catabolic process, exonucleolytic (GO:0000738)2.56038763
174regulation of mitotic spindle checkpoint (GO:1903504)2.54874713
175regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.54874713
176kinetochore assembly (GO:0051382)2.51571129
177regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.50539936
178prostate gland growth (GO:0060736)2.50388427
179sequestering of actin monomers (GO:0042989)2.49752404
180cilium or flagellum-dependent cell motility (GO:0001539)2.49671801
181protein localization to endoplasmic reticulum (GO:0070972)2.49416398
182rRNA modification (GO:0000154)2.49296539
183histone exchange (GO:0043486)2.47940709
184double-strand break repair via homologous recombination (GO:0000724)2.47854334
185polyol catabolic process (GO:0046174)2.46688592
186negative regulation of DNA-dependent DNA replication (GO:2000104)2.46383189
187indolalkylamine metabolic process (GO:0006586)2.45999017
188prenylation (GO:0097354)2.45727566

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.15244736
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.27193999
3EGR1_23403033_ChIP-Seq_LIVER_Mouse3.84663120
4RXR_22158963_ChIP-Seq_LIVER_Mouse3.33268024
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.10180005
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.03699210
7CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.91386716
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.66856641
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.64521102
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.64221073
11ZNF274_21170338_ChIP-Seq_K562_Hela2.56743145
12ELK1_19687146_ChIP-ChIP_HELA_Human2.52584305
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.49074078
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.36327517
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.33641044
16EWS_26573619_Chip-Seq_HEK293_Human2.32627886
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.27395547
18PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.22559909
19IGF1R_20145208_ChIP-Seq_DFB_Human2.22181583
20PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.18808247
21PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.10111140
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.08211658
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05328352
24SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.01767687
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.00899027
26VDR_23849224_ChIP-Seq_CD4+_Human1.91565104
27HTT_18923047_ChIP-ChIP_STHdh_Human1.91389783
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91042415
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85416872
30HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83751891
31* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.76692358
32* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.76692358
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76060612
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.74250245
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69052508
36STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.67765905
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66922674
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.61917301
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.60612643
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.60486965
41MYC_18940864_ChIP-ChIP_HL60_Human1.56278624
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54211052
43ETS1_20019798_ChIP-Seq_JURKAT_Human1.51539334
44OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50882312
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48702102
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.48448265
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.48390324
48TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.47576712
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46320520
50TAF15_26573619_Chip-Seq_HEK293_Human1.45585394
51RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.42685454
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.42563336
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38092289
54GBX2_23144817_ChIP-Seq_PC3_Human1.38062590
55FOXP3_21729870_ChIP-Seq_TREG_Human1.36336060
56ER_23166858_ChIP-Seq_MCF-7_Human1.35840904
57VDR_22108803_ChIP-Seq_LS180_Human1.33990288
58* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32846290
59SMAD4_21799915_ChIP-Seq_A2780_Human1.31263185
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30664340
61CBP_20019798_ChIP-Seq_JUKART_Human1.30397966
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30397966
63BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.27911066
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26944576
65* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26886638
66* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26829932
67HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.26313648
68PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.24785834
69TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23799031
70FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.23459465
71* BCAT_22108803_ChIP-Seq_LS180_Human1.23026989
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22919263
73TP53_22573176_ChIP-Seq_HFKS_Human1.21914271
74HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21402118
75* TCF4_22108803_ChIP-Seq_LS180_Human1.20066059
76TRIM28_21343339_ChIP-Seq_HEK293_Human1.19546403
77AR_25329375_ChIP-Seq_VCAP_Human1.18563856
78CREB1_15753290_ChIP-ChIP_HEK293T_Human1.17616611
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16386869
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.14704466
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14508175
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13939579
83EZH2_22144423_ChIP-Seq_EOC_Human1.12523601
84TAL1_26923725_Chip-Seq_HPCs_Mouse1.11750427
85JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.11360881
86IRF1_19129219_ChIP-ChIP_H3396_Human1.10996594
87NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.10385133
88SALL4_22934838_ChIP-ChIP_CD34+_Human1.10343835
89SOX2_20726797_ChIP-Seq_SW620_Human1.10316303
90STAT3_23295773_ChIP-Seq_U87_Human1.09875820
91NANOG_19829295_ChIP-Seq_ESCs_Human1.08954169
92SOX2_19829295_ChIP-Seq_ESCs_Human1.08954169
93CDX2_22108803_ChIP-Seq_LS180_Human1.08522715
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08026800
95CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.07722664
96E2F1_18555785_Chip-Seq_ESCs_Mouse1.06120623
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05034997
98CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.04970447
99* PIAS1_25552417_ChIP-Seq_VCAP_Human1.04538599
100P300_19829295_ChIP-Seq_ESCs_Human1.04519388
101SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03556426
102* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03341362
103WT1_19549856_ChIP-ChIP_CCG9911_Human1.02786586
104EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01800930
105RNF2_27304074_Chip-Seq_NSC_Mouse1.01452415
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00325382
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00325382
108RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00292239
109SMAD1_18555785_Chip-Seq_ESCs_Mouse1.00207307
110NOTCH1_21737748_ChIP-Seq_TLL_Human0.99959004
111EZH2_27294783_Chip-Seq_NPCs_Mouse0.99726441
112EST1_17652178_ChIP-ChIP_JURKAT_Human0.98162402
113STAT3_18555785_Chip-Seq_ESCs_Mouse0.97920333
114FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.97557789
115P300_18555785_Chip-Seq_ESCs_Mouse0.94916289
116CMYC_18555785_Chip-Seq_ESCs_Mouse0.94379211
117SOX17_20123909_ChIP-Seq_XEN_Mouse0.93758391
118RUNX1_27457419_Chip-Seq_LIVER_Mouse0.93402779
119CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93101754
120FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92380936
121EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.92350447
122EOMES_21245162_ChIP-Seq_HESCs_Human0.92333497
123PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.91600014
124CRX_20693478_ChIP-Seq_RETINA_Mouse0.91573114
125KLF4_18555785_Chip-Seq_ESCs_Mouse0.89409100
126P53_22387025_ChIP-Seq_ESCs_Mouse0.89175798
127CBX2_27304074_Chip-Seq_ESCs_Mouse0.88351622
128TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88258829
129AR_20517297_ChIP-Seq_VCAP_Human0.87353281
130PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86589482
131LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86005887
132CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85961328
133CTBP1_25329375_ChIP-Seq_LNCAP_Human0.85856574
134UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85663382
135FOXA1_21572438_ChIP-Seq_LNCaP_Human0.84305474
136SOX2_18555785_Chip-Seq_ESCs_Mouse0.83892189
137EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.83079189
138ETV2_25802403_ChIP-Seq_MESCs_Mouse0.82599198
139CBP_21632823_ChIP-Seq_H3396_Human0.82571518
140SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.82548222
141PU1_27457419_Chip-Seq_LIVER_Mouse0.82174213
142EED_16625203_ChIP-ChIP_MESCs_Mouse0.81420247
143SOX2_27498859_Chip-Seq_STOMACH_Mouse0.80737020
144CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.80697864
145MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.79830484
146PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.79801323
147NCOR_22424771_ChIP-Seq_293T_Human0.79700033
148PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.79420273
149* FUS_26573619_Chip-Seq_HEK293_Human0.79317409
150SUZ12_27294783_Chip-Seq_NPCs_Mouse0.79272514
151IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.79271177
152NANOG_18555785_Chip-Seq_ESCs_Mouse0.79001966

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.34225608
2MP0003806_abnormal_nucleotide_metabolis4.67800661
3MP0005360_urolithiasis3.70370149
4MP0000920_abnormal_myelination3.66108162
5MP0005085_abnormal_gallbladder_physiolo3.55331930
6MP0005365_abnormal_bile_salt3.25244147
7MP0003195_calcinosis3.11740410
8MP0006072_abnormal_retinal_apoptosis2.90838993
9MP0008875_abnormal_xenobiotic_pharmacok2.90782970
10MP0001984_abnormal_olfaction2.74054520
11MP0003690_abnormal_glial_cell2.61196057
12MP0008877_abnormal_DNA_methylation2.60506272
13MP0008058_abnormal_DNA_repair2.51548542
14MP0003011_delayed_dark_adaptation2.32927164
15MP0002837_dystrophic_cardiac_calcinosis2.29927542
16MP0005332_abnormal_amino_acid2.20428896
17MP0003136_yellow_coat_color2.19607786
18MP0002938_white_spotting2.17686958
19MP0004381_abnormal_hair_follicle2.16872448
20MP0009840_abnormal_foam_cell2.16439133
21MP0005408_hypopigmentation2.15781590
22MP0005083_abnormal_biliary_tract2.14725399
23MP0009697_abnormal_copulation2.13705752
24MP0002638_abnormal_pupillary_reflex2.13261476
25MP0001529_abnormal_vocalization2.10243902
26MP0003950_abnormal_plasma_membrane2.08249153
27MP0008789_abnormal_olfactory_epithelium2.06360760
28MP0001666_abnormal_nutrient_absorption2.06254075
29MP0002102_abnormal_ear_morphology2.05879842
30MP0002163_abnormal_gland_morphology2.04137546
31MP0005451_abnormal_body_composition2.03754087
32MP0004043_abnormal_pH_regulation2.00879071
33MP0003186_abnormal_redox_activity1.93434117
34MP0010386_abnormal_urinary_bladder1.84183497
35MP0003329_amyloid_beta_deposits1.83421286
36MP0003121_genomic_imprinting1.80530353
37MP0000569_abnormal_digit_pigmentation1.76885988
38MP0003880_abnormal_central_pattern1.75358779
39MP0005058_abnormal_lysosome_morphology1.74279364
40MP0004133_heterotaxia1.71305364
41MP0003252_abnormal_bile_duct1.70142590
42MP0004742_abnormal_vestibular_system1.68649862
43MP0001764_abnormal_homeostasis1.61323201
44MP0000427_abnormal_hair_cycle1.59669045
45MP0004147_increased_porphyrin_level1.59074692
46MP0004145_abnormal_muscle_electrophysio1.54191418
47MP0001905_abnormal_dopamine_level1.54127111
48MP0005171_absent_coat_pigmentation1.54029891
49MP0000631_abnormal_neuroendocrine_gland1.53518183
50MP0001661_extended_life_span1.53391389
51MP0010329_abnormal_lipoprotein_level1.52328142
52MP0004215_abnormal_myocardial_fiber1.52077275
53MP0000604_amyloidosis1.49452608
54MP0002118_abnormal_lipid_homeostasis1.48706462
55MP0005499_abnormal_olfactory_system1.45725181
56MP0005394_taste/olfaction_phenotype1.45725181
57MP0005584_abnormal_enzyme/coenzyme_acti1.44162237
58MP0003787_abnormal_imprinting1.41036556
59MP0001293_anophthalmia1.40485517
60MP0010030_abnormal_orbit_morphology1.40129144
61MP0002653_abnormal_ependyma_morphology1.38370429
62MP0000566_synostosis1.38213548
63MP0005645_abnormal_hypothalamus_physiol1.36828233
64MP0003634_abnormal_glial_cell1.36732812
65MP0006036_abnormal_mitochondrial_physio1.36103887
66MP0001485_abnormal_pinna_reflex1.31855915
67MP0008260_abnormal_autophagy1.25153130
68MP0004142_abnormal_muscle_tone1.25031795
69MP0005409_darkened_coat_color1.24725425
70MP0006276_abnormal_autonomic_nervous1.24551741
71MP0002751_abnormal_autonomic_nervous1.21404238
72MP0002282_abnormal_trachea_morphology1.19856941
73MP0002928_abnormal_bile_duct1.19396751
74MP0003656_abnormal_erythrocyte_physiolo1.19157852
75MP0000749_muscle_degeneration1.14351062
76MP0010094_abnormal_chromosome_stability1.14342329
77MP0004019_abnormal_vitamin_homeostasis1.14174872
78MP0005551_abnormal_eye_electrophysiolog1.11234288
79MP0003868_abnormal_feces_composition1.11047750
80MP0008438_abnormal_cutaneous_collagen1.10895696
81MP0009643_abnormal_urine_homeostasis1.09276481
82MP0003122_maternal_imprinting1.09256821
83MP0003890_abnormal_embryonic-extraembry1.08000913
84MP0004885_abnormal_endolymph1.07217361
85MP0001501_abnormal_sleep_pattern1.06166715
86MP0002233_abnormal_nose_morphology1.05028408
87MP0005391_vision/eye_phenotype1.03136147
88MP0005636_abnormal_mineral_homeostasis1.00616890
89MP0005084_abnormal_gallbladder_morpholo1.00151630
90MP0002229_neurodegeneration0.99474907
91MP0002876_abnormal_thyroid_physiology0.99309588
92MP0001929_abnormal_gametogenesis0.97768952
93MP0000383_abnormal_hair_follicle0.97448346
94MP0008872_abnormal_physiological_respon0.97261045
95MP0002277_abnormal_respiratory_mucosa0.97142962
96MP0000372_irregular_coat_pigmentation0.96797397
97MP0003632_abnormal_nervous_system0.94448471
98MP0000462_abnormal_digestive_system0.94228793
99MP0005646_abnormal_pituitary_gland0.94056698
100MP0003693_abnormal_embryo_hatching0.94002545
101MP0002234_abnormal_pharynx_morphology0.93261667
102MP0002736_abnormal_nociception_after0.92947172
103MP0002210_abnormal_sex_determination0.92823323
104MP0001286_abnormal_eye_development0.92086948
105MP0008995_early_reproductive_senescence0.89479280
106MP0010678_abnormal_skin_adnexa0.88962885
107MP0000653_abnormal_sex_gland0.88917968
108MP0003786_premature_aging0.88821916
109MP0000647_abnormal_sebaceous_gland0.88724866
110MP0005075_abnormal_melanosome_morpholog0.87149594
111MP0003937_abnormal_limbs/digits/tail_de0.86271364
112MP0005248_abnormal_Harderian_gland0.86178891
113MP0001986_abnormal_taste_sensitivity0.85787780
114MP0002295_abnormal_pulmonary_circulatio0.85782122
115MP0006035_abnormal_mitochondrial_morpho0.85469880
116MP0004134_abnormal_chest_morphology0.85227803
117MP0002138_abnormal_hepatobiliary_system0.84789206
118MP0000609_abnormal_liver_physiology0.84425765
119MP0001243_abnormal_dermal_layer0.84328019
120MP0003724_increased_susceptibility_to0.84154358
121MP0005389_reproductive_system_phenotype0.83641743
122MP0006082_CNS_inflammation0.83367855
123MP0000778_abnormal_nervous_system0.82512142
124MP0001346_abnormal_lacrimal_gland0.82378128
125MP0001145_abnormal_male_reproductive0.82271562
126MP0002933_joint_inflammation0.82159948
127MP0002132_abnormal_respiratory_system0.82058087
128MP0000639_abnormal_adrenal_gland0.80957921
129MP0003183_abnormal_peptide_metabolism0.78699713
130MP0002090_abnormal_vision0.78691132
131MP0002160_abnormal_reproductive_system0.78563448
132MP0005379_endocrine/exocrine_gland_phen0.77703227
133MP0003718_maternal_effect0.77085404
134MP0002752_abnormal_somatic_nervous0.76427814
135MP0005174_abnormal_tail_pigmentation0.75281888
136MP0005220_abnormal_exocrine_pancreas0.73623531
137MP0005253_abnormal_eye_physiology0.73580888
138MP0003755_abnormal_palate_morphology0.73455705
139MP0005319_abnormal_enzyme/_coenzyme0.73248606
140MP0002095_abnormal_skin_pigmentation0.72635780
141MP0005395_other_phenotype0.72623275
142MP0001968_abnormal_touch/_nociception0.72174111
143MP0001963_abnormal_hearing_physiology0.71862809
144MP0009745_abnormal_behavioral_response0.71199164
145MP0002557_abnormal_social/conspecific_i0.71192401
146MP0000516_abnormal_urinary_system0.71026540
147MP0002272_abnormal_nervous_system0.69105008
148MP0006292_abnormal_olfactory_placode0.67887496
149MP0009384_cardiac_valve_regurgitation0.67850531
150MP0003631_nervous_system_phenotype0.67254562
151MP0005376_homeostasis/metabolism_phenot0.66244608
152MP0005195_abnormal_posterior_eye0.66119678
153MP0009379_abnormal_foot_pigmentation0.65378678
154MP0008469_abnormal_protein_level0.59223793
155MP0003633_abnormal_nervous_system0.59033706
156MP0001542_abnormal_bone_strength0.58707222
157MP0000026_abnormal_inner_ear0.58260597
158MP0005410_abnormal_fertilization0.57994039
159MP0009764_decreased_sensitivity_to0.56266828
160MP0000230_abnormal_systemic_arterial0.55854302
161MP0003172_abnormal_lysosome_physiology0.55392156
162MP0002009_preneoplasia0.55013352
163MP0009765_abnormal_xenobiotic_induced0.54056932
164MP0001324_abnormal_eye_pigmentation0.52993430

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.78530669
2Pancreatic fibrosis (HP:0100732)4.13487197
3Intrahepatic cholestasis (HP:0001406)4.09105595
4Pancreatic cysts (HP:0001737)4.08364735
5True hermaphroditism (HP:0010459)4.07979553
6Abnormality of glycolysis (HP:0004366)4.00457716
7Increased serum pyruvate (HP:0003542)4.00457716
8Abnormality of midbrain morphology (HP:0002418)4.00445020
9Molar tooth sign on MRI (HP:0002419)4.00445020
10Medial flaring of the eyebrow (HP:0010747)3.87817742
11Parakeratosis (HP:0001036)3.79517696
12Degeneration of the lateral corticospinal tracts (HP:0002314)3.63425246
13Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.63425246
14Nephronophthisis (HP:0000090)3.55200016
15Prolonged partial thromboplastin time (HP:0003645)3.39422493
16Neurofibrillary tangles (HP:0002185)3.38815696
17Acute encephalopathy (HP:0006846)3.29274949
18Acute necrotizing encephalopathy (HP:0006965)3.29025501
19Congenital primary aphakia (HP:0007707)3.28223540
20Volvulus (HP:0002580)3.26489333
21Hepatic necrosis (HP:0002605)3.25365909
22Hyperlipoproteinemia (HP:0010980)3.25107660
23Hypobetalipoproteinemia (HP:0003563)3.19761321
24Gait imbalance (HP:0002141)3.18047132
25Xanthomatosis (HP:0000991)3.14227175
26Nephrogenic diabetes insipidus (HP:0009806)3.10542969
27Hepatocellular necrosis (HP:0001404)3.10186477
28Spastic paraparesis (HP:0002313)3.00835794
29Abnormality of the renal medulla (HP:0100957)3.00476158
30Abnormal mitochondria in muscle tissue (HP:0008316)2.98332652
31Abnormality of the labia minora (HP:0012880)2.94870119
32Deep venous thrombosis (HP:0002625)2.92132385
33Conjugated hyperbilirubinemia (HP:0002908)2.91779141
34Abnormality of the renal cortex (HP:0011035)2.90869117
353-Methylglutaconic aciduria (HP:0003535)2.90796734
36Chronic hepatic failure (HP:0100626)2.89042342
37Cerebral edema (HP:0002181)2.88603436
38Mitochondrial inheritance (HP:0001427)2.88506942
39Abnormality of methionine metabolism (HP:0010901)2.85195867
40Leukodystrophy (HP:0002415)2.81756852
41Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.81418943
42Fat malabsorption (HP:0002630)2.81216212
43Steatorrhea (HP:0002570)2.80387236
44Renal Fanconi syndrome (HP:0001994)2.79356442
45Genital tract atresia (HP:0001827)2.75926791
46Abnormality of dicarboxylic acid metabolism (HP:0010995)2.70511221
47Dicarboxylic aciduria (HP:0003215)2.70511221
48Colon cancer (HP:0003003)2.69897657
49Generalized aminoaciduria (HP:0002909)2.69496874
50Abnormality of aspartate family amino acid metabolism (HP:0010899)2.66763553
51Progressive macrocephaly (HP:0004481)2.66220115
52Bile duct proliferation (HP:0001408)2.63795847
53Abnormal biliary tract physiology (HP:0012439)2.63795847
54Vaginal atresia (HP:0000148)2.63587673
55Methylmalonic acidemia (HP:0002912)2.63334113
56Cerebral hemorrhage (HP:0001342)2.60636597
57Aplasia/Hypoplasia of the tongue (HP:0010295)2.60423356
58Abnormality of macular pigmentation (HP:0008002)2.58657387
59Tubular atrophy (HP:0000092)2.58311386
60Abnormality of monocarboxylic acid metabolism (HP:0010996)2.56314262
61Opisthotonus (HP:0002179)2.52101310
62Abnormality of serine family amino acid metabolism (HP:0010894)2.51523334
63Abnormality of glycine metabolism (HP:0010895)2.51523334
64Abnormality of urine glucose concentration (HP:0011016)2.49147238
65Glycosuria (HP:0003076)2.49147238
66Supernumerary spleens (HP:0009799)2.46578102
67Hypoglycemic coma (HP:0001325)2.46576649
68Increased CSF lactate (HP:0002490)2.44712316
69Dynein arm defect of respiratory motile cilia (HP:0012255)2.42708686
70Absent/shortened dynein arms (HP:0200106)2.42708686
71Methylmalonic aciduria (HP:0012120)2.40932358
72Abnormal ciliary motility (HP:0012262)2.40348594
73Hyperammonemia (HP:0001987)2.40310043
74Pheochromocytoma (HP:0002666)2.38595607
75Renal cortical cysts (HP:0000803)2.37434160
76Cystic liver disease (HP:0006706)2.36585183
77Vacuolated lymphocytes (HP:0001922)2.33091730
78Abnormal respiratory motile cilium morphology (HP:0005938)2.32514600
79Abnormal respiratory epithelium morphology (HP:0012253)2.32514600
80Neuroendocrine neoplasm (HP:0100634)2.32314004
81Lethargy (HP:0001254)2.31406537
82Intestinal atresia (HP:0011100)2.28450537
83Congenital ichthyosiform erythroderma (HP:0007431)2.27138728
84Congenital, generalized hypertrichosis (HP:0004540)2.25878479
85* Abnormality of fatty-acid metabolism (HP:0004359)2.25450177
86Sclerocornea (HP:0000647)2.21132503
87Optic disc pallor (HP:0000543)2.21000889
88Postaxial hand polydactyly (HP:0001162)2.20649120
89Postaxial foot polydactyly (HP:0001830)2.20049958
90Attenuation of retinal blood vessels (HP:0007843)2.18450390
91Furrowed tongue (HP:0000221)2.18429334
92Complement deficiency (HP:0004431)2.17931875
93Abnormality of the corticospinal tract (HP:0002492)2.17523240
94Lipid accumulation in hepatocytes (HP:0006561)2.17362829
95Constricted visual fields (HP:0001133)2.16533286
96Ketosis (HP:0001946)2.16212656
97Congenital hepatic fibrosis (HP:0002612)2.16126415
98Respiratory failure (HP:0002878)2.14524590
99Poor coordination (HP:0002370)2.11754465
100Paraparesis (HP:0002385)2.10830452
101Abnormal respiratory motile cilium physiology (HP:0012261)2.10658234
102Prolonged neonatal jaundice (HP:0006579)2.10015672
103Hyperbilirubinemia (HP:0002904)2.09394568
104Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.08919260
105Lactic acidosis (HP:0003128)2.07031465
106Anencephaly (HP:0002323)2.04243427
107Aplasia/Hypoplasia of the spleen (HP:0010451)2.03118460
108Joint hemorrhage (HP:0005261)2.03005567
109Male pseudohermaphroditism (HP:0000037)2.01906652
110Hypothermia (HP:0002045)2.01516931
111Asplenia (HP:0001746)1.99884871
112Premature skin wrinkling (HP:0100678)1.98492608
113Rhinitis (HP:0012384)1.98403223
114Hypolipoproteinemia (HP:0010981)1.97312323
115* Hepatosplenomegaly (HP:0001433)1.96437604
116Abnormality of serum amino acid levels (HP:0003112)1.95955729
117Delayed CNS myelination (HP:0002188)1.95889649
118Amyloidosis (HP:0011034)1.95022312
119Hypophosphatemic rickets (HP:0004912)1.94477437
120Aplasia/Hypoplasia of the tibia (HP:0005772)1.94187314
121Stridor (HP:0010307)1.93943696
122Vomiting (HP:0002013)1.93894709
123Increased hepatocellular lipid droplets (HP:0006565)1.92583901
124Abnormality of renal resorption (HP:0011038)1.92483318
125Large for gestational age (HP:0001520)1.92225284
126Autoamputation (HP:0001218)1.92223971
127Abnormality of sulfur amino acid metabolism (HP:0004339)1.91977702
128Polydipsia (HP:0001959)1.91912557
129Abnormal drinking behavior (HP:0030082)1.91912557
130Hyperglycinuria (HP:0003108)1.91220199
131Hyperglycinemia (HP:0002154)1.90616675
132Abnormality of the common coagulation pathway (HP:0010990)1.90589286
133Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.89561955
134Stenosis of the external auditory canal (HP:0000402)1.89542396
135Type 2 muscle fiber atrophy (HP:0003554)1.89211466
136Short tibia (HP:0005736)1.89123533
137Abnormal lung lobation (HP:0002101)1.88120444
138Abnormality of the intrinsic pathway (HP:0010989)1.87393816
139Exertional dyspnea (HP:0002875)1.87238455
140Increased serum lactate (HP:0002151)1.87234265
141Peripheral hypomyelination (HP:0007182)1.87143399
142Abolished electroretinogram (ERG) (HP:0000550)1.86503520
143Increased muscle lipid content (HP:0009058)1.84908018
144Enlarged kidneys (HP:0000105)1.84665859
145Median cleft lip (HP:0000161)1.84561992
146Small hand (HP:0200055)1.83939421
147Abnormality of vitamin B metabolism (HP:0004340)1.83842594
148Cerebral inclusion bodies (HP:0100314)1.83208435
149Metabolic acidosis (HP:0001942)1.81800593
150Epidermoid cyst (HP:0200040)1.81207306
151Vascular calcification (HP:0004934)1.80816865
152Abnormal gallbladder morphology (HP:0012437)1.80804907
153Patchy hypopigmentation of hair (HP:0011365)1.80787011
154Ketoacidosis (HP:0001993)1.79807435
155Tubulointerstitial nephritis (HP:0001970)1.79516901
156Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.78967797
157Abnormal protein N-linked glycosylation (HP:0012347)1.78967797
158Abnormal protein glycosylation (HP:0012346)1.78967797
159Abnormal glycosylation (HP:0012345)1.78967797
160Hypoplasia of the uterus (HP:0000013)1.78799404
161Increased intramyocellular lipid droplets (HP:0012240)1.78646102
162Specific learning disability (HP:0001328)1.78112143
163Decreased testicular size (HP:0008734)1.77997423
164Congenital stationary night blindness (HP:0007642)1.77948803
165Hypokalemic alkalosis (HP:0001949)1.77595401
166Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.76313197
167* Multicystic kidney dysplasia (HP:0000003)1.73728446
168Oculomotor apraxia (HP:0000657)1.71345494
169Sloping forehead (HP:0000340)1.70597228
170Astigmatism (HP:0000483)1.68823500
171Abnormality of the vitamin B12 metabolism (HP:0004341)1.68455961
172Prominent nasal bridge (HP:0000426)1.67755019
173Septo-optic dysplasia (HP:0100842)1.66747458

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.13449059
2FRK4.05055543
3PBK3.86157275
4OXSR13.74535984
5STK163.58871847
6MST42.99711372
7TRIM282.71034905
8BCR2.66254949
9BCKDK2.60298751
10ACVR1B2.58240530
11EPHB12.52317839
12WNK42.41031607
13ZAK2.36538998
14TNIK2.11155572
15BMPR1B2.10146377
16FGFR22.06968651
17ERBB32.04003003
18LIMK12.00495877
19MET1.99080688
20NEK61.85129886
21MAP4K21.82896021
22VRK21.74253889
23PKN11.73860352
24MAPK151.66748306
25MAPKAPK51.65149931
26CASK1.63699268
27NEK11.63031311
28CDK191.62330281
29PLK31.59155133
30MKNK11.55015244
31TESK21.53747624
32CSNK1G31.52049341
33BRSK21.44318367
34TSSK61.40577846
35ARAF1.38435930
36KIT1.35775667
37MUSK1.33519742
38MKNK21.32510297
39MAP3K41.28365351
40WEE11.24837707
41SRPK11.22292438
42CSNK1G11.17769813
43EIF2AK31.15229745
44CSNK1A1L1.14185242
45IRAK21.13900255
46EIF2AK11.13528767
47BUB11.13224751
48CAMK2B1.12529292
49TGFBR11.11998272
50GRK11.10718906
51PIK3CA1.10510826
52TEC1.09024034
53MYLK1.08147633
54PASK1.06437793
55OBSCN1.05680501
56PLK41.05016782
57DYRK20.98196156
58CLK10.96801156
59MAP3K120.95776675
60PIK3CG0.95323655
61WNK10.94103183
62CAMK2D0.93668293
63IRAK10.93431187
64PAK30.92929419
65KDR0.90792989
66TAOK30.90513742
67CAMK2G0.89125077
68MST1R0.88644698
69PRKCQ0.85729306
70TTK0.85520512
71ERBB40.84101468
72STK240.82102647
73CSNK1G20.81690135
74SGK2230.81024280
75SGK4940.81024280
76TXK0.80985353
77PLK20.80597978
78WNK30.80317061
79STK38L0.80136479
80CAMKK20.78810262
81UHMK10.78296331
82NUAK10.78163889
83ROCK20.77515330
84NME10.76337002
85EIF2AK20.75750758
86PRPF4B0.75679333
87EPHA30.74904122
88NME20.73540557
89VRK10.71426209
90MAPKAPK30.70009776
91PLK10.69199466
92IRAK40.68852821
93PNCK0.68106120
94DYRK30.67438807
95NLK0.66628708
96RPS6KA50.65023315
97STK30.64910337
98BLK0.64824160
99PRKCE0.64770601
100ADRBK20.63934850
101CDC70.59745517
102ABL20.59344095
103YES10.58395027
104MAP2K70.57774318
105RPS6KA40.56632986
106INSRR0.55779224
107BRAF0.53724531
108CDK30.53480923
109CAMK2A0.52272931
110IKBKB0.52077985
111PRKCG0.51023396
112PIM20.50958032
113TAF10.50731289
114TLK10.50503321
115EPHA40.48475846
116NTRK10.46585133
117CSF1R0.46018279
118FGR0.45500087
119NEK20.45497851
120SIK30.44352702
121IRAK30.44339445
122PHKG20.43569301
123PHKG10.43569301
124TRPM70.43172003
125PRKACB0.42145540
126BMPR20.41200938
127FLT30.40202414
128BTK0.40170438
129AURKB0.40130946
130TESK10.39635923
131MAPK40.39217299
132MAP3K140.38621698
133ADRBK10.38615196
134PDPK10.38425950
135ATM0.38396073
136PRKACA0.37975235
137GSK3A0.37332778
138LYN0.36983645
139ITK0.35676350
140CSK0.35488526
141ATR0.35337043
142TIE10.35328015
143PRKG10.35250885
144GRK70.34980773
145FER0.34756200
146CSNK1A10.33317708
147MAP2K20.32595841
148LCK0.32001579
149PINK10.31525966
150MAPK130.30645950
151IGF1R0.30420342
152CDK140.29568659
153MAPK120.28399717
154MAPK70.28295046
155CCNB10.27820121
156FYN0.27438382

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000623.70054750
2Steroid biosynthesis_Homo sapiens_hsa001003.57499792
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.16608164
4Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.09987627
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.08699553
6Protein export_Homo sapiens_hsa030602.82124340
7Sulfur metabolism_Homo sapiens_hsa009202.79487716
8Ribosome_Homo sapiens_hsa030102.60267094
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.53737037
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37254666
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.31146922
12Histidine metabolism_Homo sapiens_hsa003402.30835134
13Oxidative phosphorylation_Homo sapiens_hsa001902.19232062
14Propanoate metabolism_Homo sapiens_hsa006402.18476260
15Butanoate metabolism_Homo sapiens_hsa006502.15011922
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.12020501
17Basal transcription factors_Homo sapiens_hsa030222.08505724
18Nitrogen metabolism_Homo sapiens_hsa009101.97182018
19Fatty acid metabolism_Homo sapiens_hsa012121.93849269
20* Peroxisome_Homo sapiens_hsa041461.92233921
21Fatty acid degradation_Homo sapiens_hsa000711.90828954
22Homologous recombination_Homo sapiens_hsa034401.87194842
23Fanconi anemia pathway_Homo sapiens_hsa034601.81047133
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.80784174
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.78224652
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.77526007
27RNA degradation_Homo sapiens_hsa030181.73271400
28Parkinsons disease_Homo sapiens_hsa050121.65711577
29Chemical carcinogenesis_Homo sapiens_hsa052041.65298574
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.61966493
31Mismatch repair_Homo sapiens_hsa034301.60470947
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57507400
33Tryptophan metabolism_Homo sapiens_hsa003801.55101037
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.54235552
35Non-homologous end-joining_Homo sapiens_hsa034501.53726461
36Folate biosynthesis_Homo sapiens_hsa007901.50750096
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.48441692
38Ether lipid metabolism_Homo sapiens_hsa005651.45092967
39Glutathione metabolism_Homo sapiens_hsa004801.42987109
40Nucleotide excision repair_Homo sapiens_hsa034201.42386778
41Pentose and glucuronate interconversions_Homo sapiens_hsa000401.41750598
42Complement and coagulation cascades_Homo sapiens_hsa046101.40773929
43beta-Alanine metabolism_Homo sapiens_hsa004101.35033885
44Retinol metabolism_Homo sapiens_hsa008301.34030063
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.33487474
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.32237093
47Pyruvate metabolism_Homo sapiens_hsa006201.27875403
48Tyrosine metabolism_Homo sapiens_hsa003501.25999571
49Arginine and proline metabolism_Homo sapiens_hsa003301.25524560
50Alzheimers disease_Homo sapiens_hsa050101.23755042
51Vitamin B6 metabolism_Homo sapiens_hsa007501.22873379
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.15876182
53Phenylalanine metabolism_Homo sapiens_hsa003601.15450617
54Maturity onset diabetes of the young_Homo sapiens_hsa049501.13931287
55Proteasome_Homo sapiens_hsa030501.11070405
56PPAR signaling pathway_Homo sapiens_hsa033201.09003141
57Linoleic acid metabolism_Homo sapiens_hsa005911.06596433
58One carbon pool by folate_Homo sapiens_hsa006701.04481551
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.99941894
60Sphingolipid metabolism_Homo sapiens_hsa006000.97772292
61Caffeine metabolism_Homo sapiens_hsa002320.94266383
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93498624
63Base excision repair_Homo sapiens_hsa034100.93403203
64Purine metabolism_Homo sapiens_hsa002300.93034229
65Arginine biosynthesis_Homo sapiens_hsa002200.92270735
66Arachidonic acid metabolism_Homo sapiens_hsa005900.89822108
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.89324678
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88884726
69RNA transport_Homo sapiens_hsa030130.87554225
70Metabolic pathways_Homo sapiens_hsa011000.87339262
71Vitamin digestion and absorption_Homo sapiens_hsa049770.85695024
72Staphylococcus aureus infection_Homo sapiens_hsa051500.85524976
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82827933
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.82053683
75Carbon metabolism_Homo sapiens_hsa012000.80680321
76Huntingtons disease_Homo sapiens_hsa050160.80624379
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80486922
78Sulfur relay system_Homo sapiens_hsa041220.80336940
79Fat digestion and absorption_Homo sapiens_hsa049750.70384711
80Pyrimidine metabolism_Homo sapiens_hsa002400.69552432
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69222978
82Spliceosome_Homo sapiens_hsa030400.67340600
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.63471730
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.62575624
85ABC transporters_Homo sapiens_hsa020100.60702224
86Starch and sucrose metabolism_Homo sapiens_hsa005000.60329510
87p53 signaling pathway_Homo sapiens_hsa041150.57741870
88Selenocompound metabolism_Homo sapiens_hsa004500.57688124
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55091293
90Circadian rhythm_Homo sapiens_hsa047100.54198638
91Biosynthesis of amino acids_Homo sapiens_hsa012300.50316936
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48613122
93Pentose phosphate pathway_Homo sapiens_hsa000300.47328607
94Lysosome_Homo sapiens_hsa041420.46953511
95Fatty acid biosynthesis_Homo sapiens_hsa000610.45456786
96Vibrio cholerae infection_Homo sapiens_hsa051100.44747758
97Other glycan degradation_Homo sapiens_hsa005110.44439864
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.44375823
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44098957
100Hedgehog signaling pathway_Homo sapiens_hsa043400.42615984
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41192919
102DNA replication_Homo sapiens_hsa030300.40932861
103Collecting duct acid secretion_Homo sapiens_hsa049660.40880452
104Glycerolipid metabolism_Homo sapiens_hsa005610.40818606
105Nicotine addiction_Homo sapiens_hsa050330.40364246
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36448403
107Cell cycle_Homo sapiens_hsa041100.36273227
108Bile secretion_Homo sapiens_hsa049760.35583859
109Cyanoamino acid metabolism_Homo sapiens_hsa004600.34582592
110Olfactory transduction_Homo sapiens_hsa047400.34018942
111Regulation of autophagy_Homo sapiens_hsa041400.33999151
112Type I diabetes mellitus_Homo sapiens_hsa049400.33948711
113Basal cell carcinoma_Homo sapiens_hsa052170.31702245
114Oocyte meiosis_Homo sapiens_hsa041140.30604625
115Phagosome_Homo sapiens_hsa041450.30207944
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29750600
117Primary immunodeficiency_Homo sapiens_hsa053400.28597158
118Asthma_Homo sapiens_hsa053100.27903906
119Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.27224256
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27170001
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26463404
122N-Glycan biosynthesis_Homo sapiens_hsa005100.25096117
123Rheumatoid arthritis_Homo sapiens_hsa053230.24365561
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23190387
125Malaria_Homo sapiens_hsa051440.15800268
126RNA polymerase_Homo sapiens_hsa030200.15694769
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15324548
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.13017877
129Phototransduction_Homo sapiens_hsa047440.10488547
130Fructose and mannose metabolism_Homo sapiens_hsa000510.09729153
131Cardiac muscle contraction_Homo sapiens_hsa042600.09315317
132Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.07983546
133Prion diseases_Homo sapiens_hsa050200.07869750
134Mineral absorption_Homo sapiens_hsa049780.07508321

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