PEX26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the peroxin-26 gene family. It is probably required for protein import into peroxisomes. It anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Defects in this gene are the cause of peroxisome biogenesis disorder complementation group 8 (PBD-CG8). PBD refers to a group of peroxisomal disorders arising from a failure of protein import into the peroxisomal membrane or matrix. The PBD group is comprised of four disorders: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). Alternatively spliced transcript variants have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.01329364
2L-phenylalanine catabolic process (GO:0006559)7.01329364
3behavioral response to nicotine (GO:0035095)6.85626762
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.78030323
5L-phenylalanine metabolic process (GO:0006558)6.78030323
6aromatic amino acid family catabolic process (GO:0009074)6.26409452
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.68922207
8tryptophan catabolic process (GO:0006569)5.65877568
9indole-containing compound catabolic process (GO:0042436)5.65877568
10indolalkylamine catabolic process (GO:0046218)5.65877568
11kynurenine metabolic process (GO:0070189)5.59141032
12urea metabolic process (GO:0019627)5.47135707
13urea cycle (GO:0000050)5.47135707
14bile acid biosynthetic process (GO:0006699)5.37886343
15tryptophan metabolic process (GO:0006568)5.34401548
16glyoxylate metabolic process (GO:0046487)5.25265566
17high-density lipoprotein particle remodeling (GO:0034375)5.22933595
18alpha-linolenic acid metabolic process (GO:0036109)5.19133987
19sulfur amino acid catabolic process (GO:0000098)5.18733625
20fucose catabolic process (GO:0019317)5.14275324
21L-fucose metabolic process (GO:0042354)5.14275324
22L-fucose catabolic process (GO:0042355)5.14275324
23peptidyl-glutamic acid carboxylation (GO:0017187)5.03773881
24protein carboxylation (GO:0018214)5.03773881
25nitrogen cycle metabolic process (GO:0071941)4.97303504
26serine family amino acid catabolic process (GO:0009071)4.86113898
27cysteine metabolic process (GO:0006534)4.83089329
28regulation of protein activation cascade (GO:2000257)4.82956051
29negative regulation of fibrinolysis (GO:0051918)4.81717528
30complement activation, alternative pathway (GO:0006957)4.75872835
31bile acid metabolic process (GO:0008206)4.70719763
32regulation of cholesterol esterification (GO:0010872)4.63219342
33regulation of fibrinolysis (GO:0051917)4.60954221
34reverse cholesterol transport (GO:0043691)4.60325051
35amino-acid betaine metabolic process (GO:0006577)4.53070005
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.52169916
37lysine metabolic process (GO:0006553)4.52147074
38lysine catabolic process (GO:0006554)4.52147074
39macromolecular complex remodeling (GO:0034367)4.51376975
40plasma lipoprotein particle remodeling (GO:0034369)4.51376975
41protein-lipid complex remodeling (GO:0034368)4.51376975
42regulation of triglyceride catabolic process (GO:0010896)4.49612915
43regulation of complement activation (GO:0030449)4.49567788
44aromatic amino acid family metabolic process (GO:0009072)4.49313102
45homocysteine metabolic process (GO:0050667)4.48856196
46phospholipid efflux (GO:0033700)4.45440233
47alpha-amino acid catabolic process (GO:1901606)4.32529386
48triglyceride homeostasis (GO:0070328)4.31103358
49acylglycerol homeostasis (GO:0055090)4.31103358
50negative regulation of cholesterol transport (GO:0032375)4.28838215
51negative regulation of sterol transport (GO:0032372)4.28838215
52tyrosine metabolic process (GO:0006570)4.23909387
53regulation of cholesterol homeostasis (GO:2000188)4.22422378
54cellular ketone body metabolic process (GO:0046950)4.20639299
55bile acid and bile salt transport (GO:0015721)4.18657608
56glutamate metabolic process (GO:0006536)4.18352706
57positive regulation of CREB transcription factor activity (GO:0032793)4.16013243
58cellular modified amino acid catabolic process (GO:0042219)4.13431031
59drug catabolic process (GO:0042737)4.11791560
60regulation of hippo signaling (GO:0035330)4.10516261
61dicarboxylic acid biosynthetic process (GO:0043650)4.09067633
62coenzyme catabolic process (GO:0009109)4.04099506
63glycine metabolic process (GO:0006544)4.01942421
64cellular amino acid catabolic process (GO:0009063)4.01001235
65imidazole-containing compound metabolic process (GO:0052803)3.96802697
66indolalkylamine metabolic process (GO:0006586)3.96599370
67regulation of gene silencing by RNA (GO:0060966)3.94835596
68regulation of posttranscriptional gene silencing (GO:0060147)3.94835596
69regulation of gene silencing by miRNA (GO:0060964)3.94835596
70phospholipid homeostasis (GO:0055091)3.93290770
71low-density lipoprotein particle remodeling (GO:0034374)3.92329496
72cholesterol efflux (GO:0033344)3.88941699
73cellular response to ATP (GO:0071318)3.82845167
74positive regulation of fatty acid oxidation (GO:0046321)3.80617153
75plasma lipoprotein particle clearance (GO:0034381)3.77122226
76ethanol oxidation (GO:0006069)3.76302597
77cellular glucuronidation (GO:0052695)3.75723850
78serine family amino acid metabolic process (GO:0009069)3.75519764
79amine catabolic process (GO:0009310)3.74216015
80cellular biogenic amine catabolic process (GO:0042402)3.74216015
81arginine metabolic process (GO:0006525)3.72803480
82regulation of bile acid biosynthetic process (GO:0070857)3.68961261
83sulfation (GO:0051923)3.66733763
84exogenous drug catabolic process (GO:0042738)3.64758298
85benzene-containing compound metabolic process (GO:0042537)3.63803587
862-oxoglutarate metabolic process (GO:0006103)3.62614140
87ketone body metabolic process (GO:1902224)3.59395110
88positive regulation of lipid catabolic process (GO:0050996)3.59356114
89intestinal cholesterol absorption (GO:0030299)3.57735926
90plasma lipoprotein particle assembly (GO:0034377)3.55746167
91primary amino compound metabolic process (GO:1901160)3.55484734
92negative regulation of lipase activity (GO:0060192)3.52568876
93negative regulation of translation, ncRNA-mediated (GO:0040033)3.50879750
94regulation of translation, ncRNA-mediated (GO:0045974)3.50879750
95negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.50879750
96fibrinolysis (GO:0042730)3.49824897
97short-chain fatty acid metabolic process (GO:0046459)3.48797747
98positive regulation of fatty acid beta-oxidation (GO:0032000)3.48604777
99carboxylic acid catabolic process (GO:0046395)3.46878414
100organic acid catabolic process (GO:0016054)3.46878414
101drug transmembrane transport (GO:0006855)3.46308490
102valine metabolic process (GO:0006573)3.44813444
103cytolysis (GO:0019835)3.44650563
104indole-containing compound metabolic process (GO:0042430)3.42303664
105plasma lipoprotein particle organization (GO:0071827)3.41628701
106cholesterol homeostasis (GO:0042632)3.40924464
107epoxygenase P450 pathway (GO:0019373)3.40755425
108acetyl-CoA metabolic process (GO:0006084)3.39470748
109serine family amino acid biosynthetic process (GO:0009070)3.39450141
110lipoprotein metabolic process (GO:0042157)3.38724448
111sterol homeostasis (GO:0055092)3.38336790
112nephron epithelium morphogenesis (GO:0072088)3.38093659
113nephron tubule morphogenesis (GO:0072078)3.38093659
114serotonin metabolic process (GO:0042428)3.37944759
115fucosylation (GO:0036065)3.37169336
116urate metabolic process (GO:0046415)3.33271807
117NAD biosynthetic process (GO:0009435)3.31973797
118cellular response to exogenous dsRNA (GO:0071360)3.31819457
119uronic acid metabolic process (GO:0006063)3.30575805
120glucuronate metabolic process (GO:0019585)3.30575805
121complement activation, classical pathway (GO:0006958)3.30114350
122carnitine metabolic process (GO:0009437)3.29088291
123neuronal action potential (GO:0019228)3.28571614
124regulation of cholesterol biosynthetic process (GO:0045540)3.27764891
125gamma-aminobutyric acid transport (GO:0015812)3.26942180
126positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.24319326
127interkinetic nuclear migration (GO:0022027)3.22480429
128endosome to pigment granule transport (GO:0043485)3.22228407
129endosome to melanosome transport (GO:0035646)3.22228407
130macroautophagy (GO:0016236)3.11151842
131detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.08572206
132cAMP catabolic process (GO:0006198)3.05397343
133purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.04560301
1343-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.04560301
135cardiovascular system development (GO:0072358)2.98914548
136striated muscle atrophy (GO:0014891)2.93789370
137regulation of nuclear cell cycle DNA replication (GO:0033262)2.92970831
138negative regulation of leukocyte chemotaxis (GO:0002689)2.90171511
139flavonoid metabolic process (GO:0009812)2.89500022
140detection of light stimulus involved in sensory perception (GO:0050962)2.89237722
141detection of light stimulus involved in visual perception (GO:0050908)2.89237722
142histone-serine phosphorylation (GO:0035404)2.83500430
143negative regulation of synaptic transmission, GABAergic (GO:0032229)2.82569031
144positive regulation of sodium ion transmembrane transport (GO:1902307)2.82551997
145sulfate transmembrane transport (GO:1902358)2.80448222
146snRNA transcription (GO:0009301)2.79763648
147oxidative demethylation (GO:0070989)2.79693553
148negative regulation of sodium ion transport (GO:0010766)2.79461249
149regulation of fatty acid beta-oxidation (GO:0031998)2.78714101
150protein K48-linked deubiquitination (GO:0071108)2.73186312
151positive regulation of triglyceride biosynthetic process (GO:0010867)2.69248926
152positive regulation of fatty acid transport (GO:2000193)2.68947494
153negative regulation of reactive oxygen species metabolic process (GO:2000378)2.68726531
154membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.67310128
155peristalsis (GO:0030432)2.66209881
156neurotransmitter metabolic process (GO:0042133)2.65585274
157behavioral response to ethanol (GO:0048149)2.65294657
158cyclic nucleotide catabolic process (GO:0009214)2.64339653
159positive regulation of developmental pigmentation (GO:0048087)2.62515185
160sulfate transport (GO:0008272)2.62338578
161reflex (GO:0060004)2.60388224
162spinal cord motor neuron differentiation (GO:0021522)2.59380346
163response to pheromone (GO:0019236)2.57799552
164regulation of triglyceride biosynthetic process (GO:0010866)2.56348053
165alkaloid metabolic process (GO:0009820)2.53159570
166regulation of pigment cell differentiation (GO:0050932)2.52439157
167cornea development in camera-type eye (GO:0061303)2.51978799
168negative regulation of systemic arterial blood pressure (GO:0003085)2.51539387
169renal tubule morphogenesis (GO:0061333)2.50773097
170cilium or flagellum-dependent cell motility (GO:0001539)2.49853482
171regulation of histone phosphorylation (GO:0033127)2.49656701
172membrane depolarization during action potential (GO:0086010)2.49490240
173skeletal muscle adaptation (GO:0043501)2.48983460
174urinary tract smooth muscle contraction (GO:0014848)2.48534925
175opioid receptor signaling pathway (GO:0038003)2.48434735
176positive regulation of protein kinase C signaling (GO:0090037)2.47960225
177pyridine nucleotide biosynthetic process (GO:0019363)2.47689256
178nicotinamide nucleotide biosynthetic process (GO:0019359)2.47689256
179negative regulation of telomere maintenance (GO:0032205)2.46590996
180rRNA catabolic process (GO:0016075)2.46506213
181synaptic transmission, cholinergic (GO:0007271)2.43526674
182regulation of action potential (GO:0098900)2.41691109
183basic amino acid transport (GO:0015802)2.41450300
184regulation of establishment of cell polarity (GO:2000114)2.40772373
185cytoplasmic mRNA processing body assembly (GO:0033962)2.39516042
186kidney morphogenesis (GO:0060993)2.39200352
187phosphatidylinositol acyl-chain remodeling (GO:0036149)2.39012079

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.57801499
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.66011368
3* LXR_22158963_ChIP-Seq_LIVER_Mouse6.02158528
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.36065308
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.92475007
6EZH2_22144423_ChIP-Seq_EOC_Human4.54148723
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.48809969
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.99191450
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.93609514
10ZNF274_21170338_ChIP-Seq_K562_Hela3.67937125
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.06207401
12DROSHA_22980978_ChIP-Seq_HELA_Human2.65995127
13VDR_22108803_ChIP-Seq_LS180_Human2.65418103
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.54144342
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.51934400
16GBX2_23144817_ChIP-Seq_PC3_Human2.19957544
17AR_21572438_ChIP-Seq_LNCaP_Human2.13867132
18RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.12372534
19TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.03139507
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.5273554
21REST_21632747_ChIP-Seq_MESCs_Mouse1.89674905
22CLOCK_20551151_ChIP-Seq_293T_Human1.86291921
23FOXA2_19822575_ChIP-Seq_HepG2_Human1.85138234
24HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.82783201
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80735253
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.71863887
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.67720965
28GATA1_22025678_ChIP-Seq_K562_Human1.67023235
29JARID2_20075857_ChIP-Seq_MESCs_Mouse1.61080004
30* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.57565628
31TP53_16413492_ChIP-PET_HCT116_Human1.57371343
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56108646
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.54229166
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51893970
35JARID2_20064375_ChIP-Seq_MESCs_Mouse1.49781489
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47318408
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46552351
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.46408548
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.46069729
40ER_23166858_ChIP-Seq_MCF-7_Human1.45379174
41* HNF4A_19822575_ChIP-Seq_HepG2_Human1.44266459
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.43747819
43STAT3_23295773_ChIP-Seq_U87_Human1.43355239
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.42464861
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.41180807
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40743309
47ESR2_21235772_ChIP-Seq_MCF-7_Human1.40632671
48NOTCH1_21737748_ChIP-Seq_TLL_Human1.40272649
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.39997916
50* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38984346
51PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38914256
52SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.38884297
53SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.34427819
54ERA_21632823_ChIP-Seq_H3396_Human1.34184231
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33177468
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.32923628
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32887748
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32887748
59RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.31370147
60SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.30913396
61STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28082907
62GATA3_21878914_ChIP-Seq_MCF-7_Human1.27233367
63NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24428745
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22807887
65ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22158341
66EWS_26573619_Chip-Seq_HEK293_Human1.20968586
67AHR_22903824_ChIP-Seq_MCF-7_Human1.20157170
68CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.19756034
69FOXO3_23340844_ChIP-Seq_DLD1_Human1.19715637
70RNF2_18974828_ChIP-Seq_MESCs_Mouse1.19633827
71EZH2_18974828_ChIP-Seq_MESCs_Mouse1.19633827
72IRF1_19129219_ChIP-ChIP_H3396_Human1.19475863
73RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17547128
74TCF4_23295773_ChIP-Seq_U87_Human1.17489356
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.16835204
76GATA4_25053715_ChIP-Seq_YYC3_Human1.12758372
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.11014414
78IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10280742
79TAF2_19829295_ChIP-Seq_ESCs_Human1.10094118
80AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08902671
81ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08668074
82AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.08189015
83RXR_22108803_ChIP-Seq_LS180_Human1.07728445
84IRF8_22096565_ChIP-ChIP_GC-B_Human1.07596994
85WDR5_24793694_ChIP-Seq_LNCAP_Human1.06575370
86P53_21459846_ChIP-Seq_SAOS-2_Human1.06407643
87ESR1_21235772_ChIP-Seq_MCF-7_Human1.05974825
88EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.05906000
89NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05640703
90SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.05468295
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.04812994
92SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.04236502
93LXR_22292898_ChIP-Seq_THP-1_Human1.03812475
94TP63_19390658_ChIP-ChIP_HaCaT_Human1.03466906
95FLI1_27457419_Chip-Seq_LIVER_Mouse1.03386850
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02702444
97VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02501785
98AR_25329375_ChIP-Seq_VCAP_Human1.02314550
99MTF2_20144788_ChIP-Seq_MESCs_Mouse1.01896291
100OCT1_27270436_Chip-Seq_PROSTATE_Human1.00190858
101PRDM14_20953172_ChIP-Seq_ESCs_Human1.00026682
102TDRD3_21172665_ChIP-Seq_MCF-7_Human0.99718569
103OCT4_20526341_ChIP-Seq_ESCs_Human0.99066369
104RXRA_24833708_ChIP-Seq_LIVER_Mouse0.99049124
105* HOXB7_26014856_ChIP-Seq_BT474_Human0.98813710
106PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98459252
107REST_18959480_ChIP-ChIP_MESCs_Mouse0.98382307
108ESR1_20079471_ChIP-ChIP_T-47D_Human0.94985381
109VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94416995
110SMAD3_21741376_ChIP-Seq_ESCs_Human0.94223497
111* AR_19668381_ChIP-Seq_PC3_Human0.93820581
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93783077
113GATA6_25053715_ChIP-Seq_YYC3_Human0.93528115
114PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93501804
115E2F1_20622854_ChIP-Seq_HELA_Human0.92465176
116FOXA1_25552417_ChIP-Seq_VCAP_Human0.92216789
117CTCF_27219007_Chip-Seq_Bcells_Human0.92207758
118* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.92045914
119PHF8_20622854_ChIP-Seq_HELA_Human0.90181796
120* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.90066581
121* FOXA1_25329375_ChIP-Seq_VCAP_Human0.90066581
122TP53_22573176_ChIP-Seq_HFKS_Human0.89994346
123OCT4_19829295_ChIP-Seq_ESCs_Human0.89219887
124P300_19829295_ChIP-Seq_ESCs_Human0.89062791
125MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.89048526
126SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88724425
127RUNX2_22187159_ChIP-Seq_PCA_Human0.88368956
128RAC3_21632823_ChIP-Seq_H3396_Human0.88003329
129RACK7_27058665_Chip-Seq_MCF-7_Human0.86338267
130SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.85468290
131ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85350259
132ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84562425
133FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.84165613
134ZNF263_19887448_ChIP-Seq_K562_Human0.82081307
135FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.81382656
136RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.80439504
137CDX2_20551321_ChIP-Seq_CACO-2_Human0.78991540
138RARA_24833708_ChIP-Seq_LIVER_Mouse0.78654707
139ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.77772591
140HTT_18923047_ChIP-ChIP_STHdh_Human0.77368841
141KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.75794785
142CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.75251852
143ZNF217_24962896_ChIP-Seq_MCF-7_Human0.74851377
144ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.74841600
145ERG_21242973_ChIP-ChIP_JURKAT_Human0.73292639
146PPAR_26484153_Chip-Seq_NCI-H1993_Human0.72935562
147NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.72496577
148ESR1_15608294_ChIP-ChIP_MCF-7_Human0.71713338
149GATA1_19941826_ChIP-Seq_K562_Human0.70894781
150FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.69811347
151FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.69720177
152SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.69234970
153GATA1_19941827_ChIP-Seq_MEL_Mouse0.68072668
154CREB1_26743006_Chip-Seq_LNCaP_Human0.67755724
155SOX2_20726797_ChIP-Seq_SW620_Human0.67496549
156FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.67401894
157RARB_24833708_ChIP-Seq_LIVER_Mouse0.66172663
158GATA2_19941826_ChIP-Seq_K562_Human0.65719118
159GATA3_24758297_ChIP-Seq_MCF-7_Human0.65629124
160Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.65329243
161SALL4_18804426_ChIP-ChIP_XEN_Mouse0.63397373
162NFIB_24661679_ChIP-Seq_LUNG_Mouse0.63050551
163* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.62759373
164TP63_17297297_ChIP-ChIP_HaCaT_Human0.62461943
165NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.60200460
166KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.59836860
167TBX20_22328084_ChIP-Seq_HEART_Mouse0.59221601
168TBX20_22080862_ChIP-Seq_HEART_Mouse0.59221601
169RUNX1_27514584_Chip-Seq_MCF-7_Human0.58208406
170TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.57185736
171CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.56209345
172TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.56175128
173NRF2_20460467_ChIP-Seq_MEFs_Mouse0.55864198
174NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.55864198
175BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.55727675
176BCAT_22108803_ChIP-Seq_LS180_Human0.55211553
177KDM2B_26808549_Chip-Seq_K562_Human0.54196662
178MYC_27129775_Chip-Seq_CORNEA_Mouse0.52732939
179AUTS2_25519132_ChIP-Seq_293T-REX_Human0.52404403
180ATF3_27146783_Chip-Seq_COLON_Human0.52039770
181TCF7_22412390_ChIP-Seq_EML_Mouse0.51689359
182SOX9_24532713_ChIP-Seq_HFSC_Mouse0.51643941
183GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.51367723
184FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.50855360
185DNAJC2_21179169_ChIP-ChIP_NT2_Human0.50715342
186SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.50221888
187GATA2_21666600_ChIP-Seq_HMVEC_Human0.50093399
188BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.49174423
189P300_27058665_Chip-Seq_ZR-75-30cells_Human0.49123110

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.42583455
2MP0005360_urolithiasis6.78512762
3MP0005085_abnormal_gallbladder_physiolo6.10741884
4MP0005365_abnormal_bile_salt5.96849550
5MP0008875_abnormal_xenobiotic_pharmacok4.88964431
6MP0003252_abnormal_bile_duct3.79973241
7MP0003136_yellow_coat_color3.49407570
8MP0010329_abnormal_lipoprotein_level3.46601647
9MP0005083_abnormal_biliary_tract3.32790829
10MP0003806_abnormal_nucleotide_metabolis3.31180632
11MP0009840_abnormal_foam_cell3.05436968
12MP0000569_abnormal_digit_pigmentation3.01598200
13MP0001666_abnormal_nutrient_absorption2.78536950
14MP0003646_muscle_fatigue2.68011870
15MP0005332_abnormal_amino_acid2.65898563
16MP0005174_abnormal_tail_pigmentation2.61909645
17MP0003195_calcinosis2.58788865
18MP0001986_abnormal_taste_sensitivity2.41418367
19MP0003191_abnormal_cellular_cholesterol2.32961297
20MP0001968_abnormal_touch/_nociception2.29471705
21MP0008872_abnormal_physiological_respon2.28491019
22MP0003868_abnormal_feces_composition2.27879280
23MP0009046_muscle_twitch2.22106931
24MP0000609_abnormal_liver_physiology2.17142981
25MP0004019_abnormal_vitamin_homeostasis2.16703608
26MP0009745_abnormal_behavioral_response2.14426292
27MP0002138_abnormal_hepatobiliary_system2.13635502
28MP0002118_abnormal_lipid_homeostasis2.08415162
29MP0001501_abnormal_sleep_pattern2.02526626
30MP0005171_absent_coat_pigmentation2.00527608
31MP0001873_stomach_inflammation2.00259863
32MP0005551_abnormal_eye_electrophysiolog2.00217987
33MP0000427_abnormal_hair_cycle1.96514388
34MP0004142_abnormal_muscle_tone1.95260623
35MP0002653_abnormal_ependyma_morphology1.93993170
36MP0001485_abnormal_pinna_reflex1.93681337
37MP0003705_abnormal_hypodermis_morpholog1.85276425
38MP0002064_seizures1.82410539
39MP0005319_abnormal_enzyme/_coenzyme1.74383702
40MP0004264_abnormal_extraembryonic_tissu1.67333030
41MP0004885_abnormal_endolymph1.66619586
42MP0002254_reproductive_system_inflammat1.65342733
43MP0005645_abnormal_hypothalamus_physiol1.62355933
44MP0004133_heterotaxia1.62118023
45MP0002638_abnormal_pupillary_reflex1.61149150
46MP0004147_increased_porphyrin_level1.59573014
47MP0002272_abnormal_nervous_system1.58925890
48MP0002735_abnormal_chemical_nociception1.57727660
49MP0002063_abnormal_learning/memory/cond1.57275845
50MP0009379_abnormal_foot_pigmentation1.55108726
51MP0009643_abnormal_urine_homeostasis1.53574434
52MP0002572_abnormal_emotion/affect_behav1.53346945
53MP0001664_abnormal_digestion1.46678123
54MP0010234_abnormal_vibrissa_follicle1.43607269
55MP0001970_abnormal_pain_threshold1.42221744
56MP0003635_abnormal_synaptic_transmissio1.42043122
57MP0002733_abnormal_thermal_nociception1.39381231
58MP0003283_abnormal_digestive_organ1.39104980
59MP0005451_abnormal_body_composition1.37513619
60MP0001502_abnormal_circadian_rhythm1.37273751
61MP0002067_abnormal_sensory_capabilities1.37210025
62MP0000470_abnormal_stomach_morphology1.33071044
63MP0004742_abnormal_vestibular_system1.32873991
64MP0005584_abnormal_enzyme/coenzyme_acti1.32080432
65MP0004924_abnormal_behavior1.31488877
66MP0005386_behavior/neurological_phenoty1.31488877
67MP0005423_abnormal_somatic_nervous1.31391452
68MP0002876_abnormal_thyroid_physiology1.30618222
69MP0000631_abnormal_neuroendocrine_gland1.27475553
70MP0010368_abnormal_lymphatic_system1.25216604
71MP0001764_abnormal_homeostasis1.24549436
72MP0003890_abnormal_embryonic-extraembry1.23465830
73MP0000598_abnormal_liver_morphology1.22083793
74MP0002736_abnormal_nociception_after1.21055031
75MP0002557_abnormal_social/conspecific_i1.20292560
76MP0004145_abnormal_muscle_electrophysio1.18463381
77MP0001486_abnormal_startle_reflex1.18019327
78MP0005220_abnormal_exocrine_pancreas1.17419309
79MP0001663_abnormal_digestive_system1.16272152
80MP0009697_abnormal_copulation1.14866207
81MP0002078_abnormal_glucose_homeostasis1.13688423
82MP0001919_abnormal_reproductive_system1.08930853
83MP0000383_abnormal_hair_follicle1.07847773
84MP0008877_abnormal_DNA_methylation1.07702960
85MP0003119_abnormal_digestive_system1.07634410
86MP0002938_white_spotting1.07128204
87MP0002734_abnormal_mechanical_nocicepti1.05705422
88MP0002160_abnormal_reproductive_system1.05148230
89MP0001756_abnormal_urination1.04828318
90MP0000778_abnormal_nervous_system1.03050442
91MP0003632_abnormal_nervous_system0.99774503
92MP0005636_abnormal_mineral_homeostasis0.98306084
93MP0000604_amyloidosis0.94760857
94MP0000026_abnormal_inner_ear0.94456246
95MP0005389_reproductive_system_phenotype0.94195064
96MP0003045_fibrosis0.94074867
97MP0004130_abnormal_muscle_cell0.93584002
98MP0005647_abnormal_sex_gland0.92869044
99MP0000566_synostosis0.91574411
100MP0003879_abnormal_hair_cell0.90041550
101MP0009642_abnormal_blood_homeostasis0.89980051
102MP0002796_impaired_skin_barrier0.88575510
103MP0005195_abnormal_posterior_eye0.87018469
104MP0004782_abnormal_surfactant_physiolog0.86675590
105MP0005670_abnormal_white_adipose0.86313490
106MP0009764_decreased_sensitivity_to0.85635411
107MP0005310_abnormal_salivary_gland0.85475179
108MP0003656_abnormal_erythrocyte_physiolo0.85012954
109MP0001944_abnormal_pancreas_morphology0.84843823
110MP0005381_digestive/alimentary_phenotyp0.84836830
111MP0005084_abnormal_gallbladder_morpholo0.84802810
112MP0003011_delayed_dark_adaptation0.83833037
113MP0002095_abnormal_skin_pigmentation0.83185052
114MP0009763_increased_sensitivity_to0.82889189
115MP0001440_abnormal_grooming_behavior0.80685179
116MP0000015_abnormal_ear_pigmentation0.79945212
117MP0002877_abnormal_melanocyte_morpholog0.79855352
118MP0002102_abnormal_ear_morphology0.78988066
119MP0003878_abnormal_ear_physiology0.78905734
120MP0005377_hearing/vestibular/ear_phenot0.78905734
121MP0004043_abnormal_pH_regulation0.78832297
122MP0005334_abnormal_fat_pad0.78222513
123MP0000685_abnormal_immune_system0.75157493
124MP0008469_abnormal_protein_level0.74413370
125MP0002009_preneoplasia0.73933445
126MP0001324_abnormal_eye_pigmentation0.73814485
127MP0000955_abnormal_spinal_cord0.73640665
128MP0005448_abnormal_energy_balance0.72971857
129MP0009780_abnormal_chondrocyte_physiolo0.72882884
130MP0002752_abnormal_somatic_nervous0.72118774
131MP0005535_abnormal_body_temperature0.71659234
132MP0002928_abnormal_bile_duct0.71574448
133MP0003300_gastrointestinal_ulcer0.68329118
134MP0001881_abnormal_mammary_gland0.66933795
135MP0000579_abnormal_nail_morphology0.66615231
136MP0002971_abnormal_brown_adipose0.66477807
137MP0003186_abnormal_redox_activity0.66191500
138MP0002693_abnormal_pancreas_physiology0.63945464
139MP0009765_abnormal_xenobiotic_induced0.63943790
140MP0001765_abnormal_ion_homeostasis0.59998757
141MP0003953_abnormal_hormone_level0.59647750
142MP0002136_abnormal_kidney_physiology0.59011508
143MP0005058_abnormal_lysosome_morphology0.58072317
144MP0008961_abnormal_basal_metabolism0.57399313
145MP0002909_abnormal_adrenal_gland0.57390054
146MP0005408_hypopigmentation0.56856983
147MP0002060_abnormal_skin_morphology0.56086468
148MP0001661_extended_life_span0.55486356
149MP0003329_amyloid_beta_deposits0.54945956
150MP0003638_abnormal_response/metabolism_0.54524105
151MP0008874_decreased_physiological_sensi0.54428108
152MP0005376_homeostasis/metabolism_phenot0.53922702
153MP0009672_abnormal_birth_weight0.53280086
154MP0002822_catalepsy0.53111896
155MP0005666_abnormal_adipose_tissue0.52688498
156MP0000639_abnormal_adrenal_gland0.52483165
157MP0005187_abnormal_penis_morphology0.51011411
158MP0005248_abnormal_Harderian_gland0.49974589
159MP0002837_dystrophic_cardiac_calcinosis0.49461703
160MP0009053_abnormal_anal_canal0.49253204
161MP0004947_skin_inflammation0.48074435
162MP0000538_abnormal_urinary_bladder0.47818478
163MP0010386_abnormal_urinary_bladder0.47325652
164MP0006036_abnormal_mitochondrial_physio0.47193764
165MP0005266_abnormal_metabolism0.45945427
166MP0000230_abnormal_systemic_arterial0.44426607
167MP0005464_abnormal_platelet_physiology0.41881255
168MP0004185_abnormal_adipocyte_glucose0.41809345
169MP0003959_abnormal_lean_body0.40879514
170MP0009384_cardiac_valve_regurgitation0.39682573
171MP0005395_other_phenotype0.38619226
172MP0001243_abnormal_dermal_layer0.38330565
173MP0003943_abnormal_hepatobiliary_system0.38160278
174MP0009115_abnormal_fat_cell0.37542729
175MP0005167_abnormal_blood-brain_barrier0.36792708

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.89165427
2Deep venous thrombosis (HP:0002625)6.80478119
3Intrahepatic cholestasis (HP:0001406)6.57337906
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.22600292
5Xanthomatosis (HP:0000991)5.64352057
6Prolonged partial thromboplastin time (HP:0003645)5.53392933
7Hypobetalipoproteinemia (HP:0003563)5.43798285
8Hyperlipoproteinemia (HP:0010980)4.81470316
9Complement deficiency (HP:0004431)4.67243640
10Genetic anticipation (HP:0003743)4.64998332
11Hypoglycemic coma (HP:0001325)4.60627547
12Abnormality of the common coagulation pathway (HP:0010990)4.41145836
13Ketosis (HP:0001946)4.40953401
14Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)4.33675540
15Birth length less than 3rd percentile (HP:0003561)4.28197281
16Hyperventilation (HP:0002883)4.26317450
17Abnormality of glutamine family amino acid metabolism (HP:0010902)4.20586811
18Epidermoid cyst (HP:0200040)4.20098022
19Hypolipoproteinemia (HP:0010981)4.15767185
20Hyperammonemia (HP:0001987)4.12763868
21Hyperglycinemia (HP:0002154)4.06834018
22Joint hemorrhage (HP:0005261)4.00501695
23Abnormality of the intrinsic pathway (HP:0010989)3.94660054
24Abnormality of sulfur amino acid metabolism (HP:0004339)3.88714727
25Hyperglycinuria (HP:0003108)3.87311930
26Congenital stationary night blindness (HP:0007642)3.85784358
27Abnormality of alanine metabolism (HP:0010916)3.82343061
28Hyperalaninemia (HP:0003348)3.82343061
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.82343061
30Clumsiness (HP:0002312)3.80090757
31Pancreatic cysts (HP:0001737)3.79197249
32Hypoalphalipoproteinemia (HP:0003233)3.78573915
33Type II lissencephaly (HP:0007260)3.75217898
34Protruding tongue (HP:0010808)3.74639647
35Ketoacidosis (HP:0001993)3.73590915
36Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.72010249
37Fat malabsorption (HP:0002630)3.70986077
38Molar tooth sign on MRI (HP:0002419)3.67073239
39Abnormality of midbrain morphology (HP:0002418)3.67073239
40Conjugated hyperbilirubinemia (HP:0002908)3.63761332
41Abnormality of glycine metabolism (HP:0010895)3.63439592
42Abnormality of serine family amino acid metabolism (HP:0010894)3.63439592
43Hypoglycemic seizures (HP:0002173)3.52488061
44Patellar aplasia (HP:0006443)3.52429185
45Progressive cerebellar ataxia (HP:0002073)3.50156464
46Abnormality of aspartate family amino acid metabolism (HP:0010899)3.47860148
47Abnormality of complement system (HP:0005339)3.45531785
48Large for gestational age (HP:0001520)3.45106930
49Abnormality of methionine metabolism (HP:0010901)3.43244271
50Decreased circulating renin level (HP:0003351)3.42450054
51Increased neuronal autofluorescent lipopigment (HP:0002074)3.35744288
52Cerebellar dysplasia (HP:0007033)3.28736425
53Attenuation of retinal blood vessels (HP:0007843)3.26462105
54Inability to walk (HP:0002540)3.24047067
55Aplasia/Hypoplasia of the patella (HP:0006498)3.23927437
56Hypercholesterolemia (HP:0003124)3.19758141
57Abnormality of fatty-acid metabolism (HP:0004359)3.16126605
58Hyperinsulinemic hypoglycemia (HP:0000825)3.15378866
59Tubular atrophy (HP:0000092)3.09380273
60Abnormality of pyrimidine metabolism (HP:0004353)3.09144978
61Nephronophthisis (HP:0000090)3.05422243
62Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.04684267
63Pancreatic fibrosis (HP:0100732)3.04643658
64Abnormality of nucleobase metabolism (HP:0010932)2.96308496
65Skin nodule (HP:0200036)2.96075169
66Gout (HP:0001997)2.93868131
67Hepatocellular carcinoma (HP:0001402)2.91539234
68True hermaphroditism (HP:0010459)2.90955993
69Abnormality of purine metabolism (HP:0004352)2.89890255
70Abnormality of the pons (HP:0007361)2.89353829
71Hypoplasia of the pons (HP:0012110)2.88987025
72Hyperbilirubinemia (HP:0002904)2.88959069
73Hyperglycemia (HP:0003074)2.87565882
74Breast hypoplasia (HP:0003187)2.87447424
75Delayed CNS myelination (HP:0002188)2.85853960
76Late onset (HP:0003584)2.82732899
77Spontaneous abortion (HP:0005268)2.69271980
78Progressive inability to walk (HP:0002505)2.68633896
79Cystic liver disease (HP:0006706)2.67978105
80Abnormality of the renal medulla (HP:0100957)2.65790714
81Myocardial infarction (HP:0001658)2.62389839
82Gaze-evoked nystagmus (HP:0000640)2.61154006
83Symptomatic seizures (HP:0011145)2.60478960
84Hypochromic microcytic anemia (HP:0004840)2.60458996
85Chronic hepatic failure (HP:0100626)2.57806062
86Steatorrhea (HP:0002570)2.56695833
87Pendular nystagmus (HP:0012043)2.56323821
88Chorioretinal atrophy (HP:0000533)2.55962419
89Mitral stenosis (HP:0001718)2.53728751
90Furrowed tongue (HP:0000221)2.53608991
91Abnormality of serum amino acid levels (HP:0003112)2.52703341
92Concave nail (HP:0001598)2.50820069
93Metabolic acidosis (HP:0001942)2.50607392
94Partial agenesis of the corpus callosum (HP:0001338)2.48621308
95Spastic diplegia (HP:0001264)2.47610844
96Increased cerebral lipofuscin (HP:0011813)2.46463512
97Irritability (HP:0000737)2.45049047
98Abnormality of the renal cortex (HP:0011035)2.41542078
99Neonatal onset (HP:0003623)2.40992155
100Severe muscular hypotonia (HP:0006829)2.39678752
101Esophageal varix (HP:0002040)2.39234094
102Vascular calcification (HP:0004934)2.37261961
103Malnutrition (HP:0004395)2.34181860
104Congenital, generalized hypertrichosis (HP:0004540)2.32643625
105Broad-based gait (HP:0002136)2.32478653
106Lissencephaly (HP:0001339)2.32262524
107Dicarboxylic aciduria (HP:0003215)2.31842862
108Abnormality of dicarboxylic acid metabolism (HP:0010995)2.31842862
109Polydipsia (HP:0001959)2.29603223
110Abnormal drinking behavior (HP:0030082)2.29603223
111Systemic lupus erythematosus (HP:0002725)2.29241753
112Fair hair (HP:0002286)2.28959012
113Abnormality of the pancreatic islet cells (HP:0006476)2.27209774
114Abnormality of endocrine pancreas physiology (HP:0012093)2.27209774
115Duplicated collecting system (HP:0000081)2.25698009
116Abnormality of proline metabolism (HP:0010907)2.23487372
117Hydroxyprolinuria (HP:0003080)2.23487372
118Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.23457476
119Abnormality of renin-angiotensin system (HP:0000847)2.20918031
120Abnormal gallbladder morphology (HP:0012437)2.20444430
121Mesangial abnormality (HP:0001966)2.19823326
122Generalized aminoaciduria (HP:0002909)2.19292148
123Menorrhagia (HP:0000132)2.18563776
124Hypoplastic ischia (HP:0003175)2.16627950
125Bulbous nose (HP:0000414)2.16101204
126Bronchomalacia (HP:0002780)2.15544629
127Sensorimotor neuropathy (HP:0007141)2.14016145
128Febrile seizures (HP:0002373)2.13800358
129Keratoconus (HP:0000563)2.13789936
130Increased corneal curvature (HP:0100692)2.13789936
131Gingival bleeding (HP:0000225)2.13422953
132Abnormality of the renal collecting system (HP:0004742)2.09786056
133Lethargy (HP:0001254)2.09664343
134Cardiovascular calcification (HP:0011915)2.09058193
135Pancreatitis (HP:0001733)2.08255549
136Metabolic alkalosis (HP:0200114)2.07802805
137Cholelithiasis (HP:0001081)2.07621540
138Acanthocytosis (HP:0001927)2.06792469
139Glomerulonephritis (HP:0000099)2.03558378
140Rib fusion (HP:0000902)2.02569678
141Abolished electroretinogram (ERG) (HP:0000550)2.00740047
142Macroglossia (HP:0000158)1.98698210
143Tachypnea (HP:0002789)1.97411099
144Congenital sensorineural hearing impairment (HP:0008527)1.97340694
145Thrombophlebitis (HP:0004418)1.96643207
146Generalized hypopigmentation of hair (HP:0011358)1.95453267
147Global brain atrophy (HP:0002283)1.95194113
148Broad metatarsal (HP:0001783)1.93548089
149Alkalosis (HP:0001948)1.89914375
150Amelogenesis imperfecta (HP:0000705)1.89536549
151Impaired smooth pursuit (HP:0007772)1.88102734
152Enlarged kidneys (HP:0000105)1.88030687
153Confusion (HP:0001289)1.86550342
154Diplopia (HP:0000651)1.86107628
155Abnormality of binocular vision (HP:0011514)1.86107628
156Abnormal gallbladder physiology (HP:0012438)1.85922018
157Cholecystitis (HP:0001082)1.85922018
158Abnormality of the gallbladder (HP:0005264)1.85692144
159Widely spaced teeth (HP:0000687)1.84662022
160Vomiting (HP:0002013)1.83883434
161Sclerocornea (HP:0000647)1.83200119
162Abnormal enzyme/coenzyme activity (HP:0012379)1.82627544
163Rectal prolapse (HP:0002035)1.81604310
164Renovascular hypertension (HP:0100817)1.81589763
165Abnormality of the ischium (HP:0003174)1.81242856
166Status epilepticus (HP:0002133)1.80528182
167Recurrent gram-negative bacterial infections (HP:0005420)1.79223637
168Increased purine levels (HP:0004368)1.79165797
169Hyperuricemia (HP:0002149)1.79165797
170Abnormal number of erythroid precursors (HP:0012131)1.78418215
171Amyloidosis (HP:0011034)1.78337485
172Hemorrhage of the eye (HP:0011885)1.77972043
173Pancreatic islet-cell hyperplasia (HP:0004510)1.77842108
174Abnormal cartilage morphology (HP:0002763)1.76683251
175Back pain (HP:0003418)1.75601009
176Decreased central vision (HP:0007663)1.75282884
177Cerebral edema (HP:0002181)1.74636695
178Abnormal albumin level (HP:0012116)1.74014244
179Hypoalbuminemia (HP:0003073)1.74014244
180Rickets (HP:0002748)1.73795393
181Ulnar claw (HP:0001178)1.73435686
182Intellectual disability, severe (HP:0010864)1.72880434
183Absent speech (HP:0001344)1.72424094
184Dysmetric saccades (HP:0000641)1.71344559
185Stroke (HP:0001297)1.70814564
186Abnormality of transition element cation homeostasis (HP:0011030)1.70260941
187Absent thumb (HP:0009777)1.69585487
188Polyuria (HP:0000103)1.69572351
189Death in childhood (HP:0003819)1.68937673
190Pachygyria (HP:0001302)1.67216422
191Abnormality of the carotid arteries (HP:0005344)1.67087659
192Bony spicule pigmentary retinopathy (HP:0007737)1.66725549
193Congenital hepatic fibrosis (HP:0002612)1.65917653
194Stomach cancer (HP:0012126)1.65277923
195Decreased electroretinogram (ERG) amplitude (HP:0000654)1.60421873
196Anencephaly (HP:0002323)1.59341334

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.45963509
2ACVR1B4.45783460
3BCKDK4.15037540
4TAOK34.03391657
5INSRR3.87769135
6SIK13.79506880
7ADRBK23.62065930
8BMPR1B3.40462542
9TRIB33.13444026
10TLK13.01834078
11FGFR43.00946925
12PKN22.94002647
13PTK62.28094622
14ZAK2.26695659
15MAP2K42.22379374
16FRK1.96527160
17GRK11.85857026
18TGFBR11.78732102
19ERBB41.72763592
20LATS11.70005141
21AKT31.69993397
22FLT31.66838860
23MST1R1.57866663
24MAP3K71.52188331
25PIK3CA1.48092989
26MAP3K61.45292108
27CAMKK21.41895693
28ADRBK11.39743452
29MAPK111.39260552
30DAPK21.34540845
31STK391.34334479
32MAP2K31.31637387
33OXSR11.30786143
34TYRO31.28439781
35PNCK1.21579492
36SGK31.19184240
37TYK21.18612935
38WNK11.18031449
39CASK1.14753052
40JAK21.13861939
41MAPK151.12207168
42MAPK131.11345386
43MAP3K101.10390129
44RPS6KA61.09543032
45ITK1.07331290
46PDGFRA1.07091514
47NTRK31.05513999
48RET1.04651682
49PTK21.02786836
50JAK11.01959635
51EEF2K1.01610911
52MAP2K21.01271672
53DYRK1B0.99195721
54MKNK20.98696461
55MARK10.98438760
56PINK10.95742989
57MAP2K60.94941970
58STK110.94348712
59SGK20.93764275
60PIK3CG0.93551457
61PRKCH0.92523203
62MAP3K10.89765857
63JAK30.89276383
64TRPM70.88631200
65MAP3K20.86909579
66GRK60.86256949
67BMX0.85834789
68MAP3K140.80030496
69NEK20.79102486
70EPHB10.79032351
71RPS6KA50.78279454
72FGFR20.78238658
73PRKAA20.75745595
74STK30.75644220
75FGFR30.75542659
76MELK0.75174968
77MAP4K10.74518259
78PRKAA10.74429732
79TIE10.72707661
80CDK60.72675429
81MTOR0.71782085
82ZAP700.71557226
83PRKCZ0.69509612
84PRKCG0.69300722
85NEK90.68271729
86CAMK10.66970613
87EPHA20.66918457
88NTRK20.66723394
89MAP3K50.65862814
90ERBB20.65707256
91MAPKAPK50.64518934
92PTK2B0.63296823
93MAP2K10.63231060
94MAPK70.62456140
95RIPK10.62377006
96TNIK0.61130610
97MAPK120.61087545
98STK38L0.60249074
99IRAK10.59311264
100MET0.59175735
101CDC42BPA0.58638127
102ICK0.58554175
103CAMK40.58085825
104PRKCQ0.56972081
105KIT0.55178679
106PKN10.53935206
107IKBKB0.53210302
108MAP3K40.52979927
109HIPK20.52287302
110CHUK0.52018672
111PAK30.51247409
112SGK4940.51062030
113SGK2230.51062030
114CSK0.50993468
115PRKD20.50798035
116CAMK1D0.50754884
117TBK10.50439415
118PRKACG0.50434761
119FER0.50381546
120NLK0.50299948
121WNK30.49949109
122IRAK40.49352759
123MARK20.48167000
124NTRK10.48005708
125CDK120.47353544
126MAP3K110.47244369
127GSK3A0.45672918
128WNK40.44166565
129MAP3K30.43984925
130CAMKK10.43860137
131PRKD30.43686435
132IGF1R0.43498573
133EPHB20.43240818
134MAPK40.43157987
135MAPKAPK30.41986799
136SIK20.41661215
137PDPK10.41503713
138CAMK1G0.41233381
139STK380.40798243
140EPHA30.39807076
141SYK0.39146310
142SCYL20.38410463
143KSR20.38149019
144NUAK10.38108478
145PDGFRB0.36556559
146MAP3K130.36236346
147CHEK20.35240709
148RPS6KA20.34705506
149MUSK0.34660800
150TNK20.34024247
151PHKG20.33281782
152PHKG10.33281782
153SIK30.31839790
154MAPK80.31822541
155FGFR10.31456375

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.39550431
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.68050517
3Nitrogen metabolism_Homo sapiens_hsa009103.53655662
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.34816821
5Arginine biosynthesis_Homo sapiens_hsa002203.18034603
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.90511411
7Tryptophan metabolism_Homo sapiens_hsa003802.80336495
8Complement and coagulation cascades_Homo sapiens_hsa046102.53846381
9Fatty acid degradation_Homo sapiens_hsa000712.50708192
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.49911649
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.39310584
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.39014195
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.31842811
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.18779240
15Maturity onset diabetes of the young_Homo sapiens_hsa049502.18065520
16Nicotine addiction_Homo sapiens_hsa050332.16900070
17Butanoate metabolism_Homo sapiens_hsa006502.15058293
18Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.12955012
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.99770980
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.97193789
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.91159802
22* Peroxisome_Homo sapiens_hsa041461.89016034
23Caffeine metabolism_Homo sapiens_hsa002321.88017666
24PPAR signaling pathway_Homo sapiens_hsa033201.84412849
25Phototransduction_Homo sapiens_hsa047441.83514095
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.82922968
27Histidine metabolism_Homo sapiens_hsa003401.82328948
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.80523196
29Ether lipid metabolism_Homo sapiens_hsa005651.74247074
30Propanoate metabolism_Homo sapiens_hsa006401.72847812
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.72414113
32Chemical carcinogenesis_Homo sapiens_hsa052041.68936799
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.66575126
34Fatty acid metabolism_Homo sapiens_hsa012121.66312734
35beta-Alanine metabolism_Homo sapiens_hsa004101.65559185
36Bile secretion_Homo sapiens_hsa049761.64191325
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.63638808
38Sulfur metabolism_Homo sapiens_hsa009201.60609927
39Phenylalanine metabolism_Homo sapiens_hsa003601.59406148
40Selenocompound metabolism_Homo sapiens_hsa004501.58009976
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.56545652
42Morphine addiction_Homo sapiens_hsa050321.54271054
43Retinol metabolism_Homo sapiens_hsa008301.52469869
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48638556
45Staphylococcus aureus infection_Homo sapiens_hsa051501.46506209
46Taste transduction_Homo sapiens_hsa047421.44543662
47Starch and sucrose metabolism_Homo sapiens_hsa005001.35027674
48Fat digestion and absorption_Homo sapiens_hsa049751.33535227
49ABC transporters_Homo sapiens_hsa020101.32769398
50Tyrosine metabolism_Homo sapiens_hsa003501.31863332
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.29866746
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29419165
53Glutamatergic synapse_Homo sapiens_hsa047241.23619729
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20033798
55Pyruvate metabolism_Homo sapiens_hsa006201.18071430
56Cyanoamino acid metabolism_Homo sapiens_hsa004601.17425660
57Lysine degradation_Homo sapiens_hsa003101.14182724
58Calcium signaling pathway_Homo sapiens_hsa040201.11997612
59Circadian entrainment_Homo sapiens_hsa047131.11675947
60Cysteine and methionine metabolism_Homo sapiens_hsa002701.09176739
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.08332917
62Dorso-ventral axis formation_Homo sapiens_hsa043201.06350040
63Biosynthesis of amino acids_Homo sapiens_hsa012301.04252276
64Folate biosynthesis_Homo sapiens_hsa007901.04200935
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02159050
66Vascular smooth muscle contraction_Homo sapiens_hsa042701.00911458
67Mineral absorption_Homo sapiens_hsa049781.00003235
68Cholinergic synapse_Homo sapiens_hsa047250.99569377
69Serotonergic synapse_Homo sapiens_hsa047260.98361104
70Cocaine addiction_Homo sapiens_hsa050300.98021775
71Carbon metabolism_Homo sapiens_hsa012000.95664185
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94361996
73Homologous recombination_Homo sapiens_hsa034400.88445838
74Olfactory transduction_Homo sapiens_hsa047400.87219926
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86732919
76Arachidonic acid metabolism_Homo sapiens_hsa005900.84770700
77Fatty acid elongation_Homo sapiens_hsa000620.84104819
78Salivary secretion_Homo sapiens_hsa049700.82871839
79Gastric acid secretion_Homo sapiens_hsa049710.81149937
80Arginine and proline metabolism_Homo sapiens_hsa003300.79799578
81GABAergic synapse_Homo sapiens_hsa047270.79219785
82Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78197272
83Long-term depression_Homo sapiens_hsa047300.73241778
84Glycerolipid metabolism_Homo sapiens_hsa005610.69776794
85Vitamin digestion and absorption_Homo sapiens_hsa049770.69753630
86Sulfur relay system_Homo sapiens_hsa041220.69645837
87One carbon pool by folate_Homo sapiens_hsa006700.66260777
88Fanconi anemia pathway_Homo sapiens_hsa034600.64689601
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64052848
90cAMP signaling pathway_Homo sapiens_hsa040240.63883290
91Oxytocin signaling pathway_Homo sapiens_hsa049210.62896707
92Steroid biosynthesis_Homo sapiens_hsa001000.62608354
93Insulin resistance_Homo sapiens_hsa049310.60887840
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60603791
95Asthma_Homo sapiens_hsa053100.60376013
96Dopaminergic synapse_Homo sapiens_hsa047280.58858959
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56295381
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55819363
99MAPK signaling pathway_Homo sapiens_hsa040100.52092642
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50046243
101Pancreatic secretion_Homo sapiens_hsa049720.49254581
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48161979
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47088322
104Amphetamine addiction_Homo sapiens_hsa050310.46031703
105Fatty acid biosynthesis_Homo sapiens_hsa000610.45744234
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45002470
107Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44850598
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.44314809
109RNA polymerase_Homo sapiens_hsa030200.43047161
110Basal cell carcinoma_Homo sapiens_hsa052170.43012096
111Galactose metabolism_Homo sapiens_hsa000520.42549257
112Protein digestion and absorption_Homo sapiens_hsa049740.39590052
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.38833923
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.37639289
115TNF signaling pathway_Homo sapiens_hsa046680.37578352
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36337070
117Estrogen signaling pathway_Homo sapiens_hsa049150.36055243
118Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.35814040
119Axon guidance_Homo sapiens_hsa043600.34530487
120Glucagon signaling pathway_Homo sapiens_hsa049220.33669723
121Glutathione metabolism_Homo sapiens_hsa004800.33355361
122Vitamin B6 metabolism_Homo sapiens_hsa007500.32168015
123Prion diseases_Homo sapiens_hsa050200.31919344
124Graft-versus-host disease_Homo sapiens_hsa053320.31913023
125Renin secretion_Homo sapiens_hsa049240.31585085
126Systemic lupus erythematosus_Homo sapiens_hsa053220.30525883
127Primary immunodeficiency_Homo sapiens_hsa053400.30456180
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30220962
129Pentose phosphate pathway_Homo sapiens_hsa000300.28760825
130Metabolic pathways_Homo sapiens_hsa011000.28626436
131Fructose and mannose metabolism_Homo sapiens_hsa000510.28394930
132Linoleic acid metabolism_Homo sapiens_hsa005910.24871471
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.24257244
134AMPK signaling pathway_Homo sapiens_hsa041520.22791249
135Type II diabetes mellitus_Homo sapiens_hsa049300.20113762
136Insulin signaling pathway_Homo sapiens_hsa049100.19038199
137Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.17310541
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.15912804
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.15757917
140Glycosaminoglycan degradation_Homo sapiens_hsa005310.11850149
141Thyroid hormone synthesis_Homo sapiens_hsa049180.08078148
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.05194317
143Circadian rhythm_Homo sapiens_hsa047100.04600698
144Prolactin signaling pathway_Homo sapiens_hsa049170.03987400
145Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.01265083
146Thyroid cancer_Homo sapiens_hsa05216-0.1025709
147Endometrial cancer_Homo sapiens_hsa05213-0.0809548
148mTOR signaling pathway_Homo sapiens_hsa04150-0.0744429
149Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0739453
150Lysosome_Homo sapiens_hsa04142-0.0669062
151Insulin secretion_Homo sapiens_hsa04911-0.0589448
152Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0426422
153Bladder cancer_Homo sapiens_hsa05219-0.0366287
154Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0363590
155Hepatitis C_Homo sapiens_hsa05160-0.0265815
156Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0145534

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