PEX3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is involved in peroxisome biosynthesis and integrity. It assembles membrane vesicles before the matrix proteins are translocated. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause Zellweger syndrome (ZWS). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.57033800
2L-phenylalanine catabolic process (GO:0006559)5.57033800
3proteasome assembly (GO:0043248)5.53224215
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.35218189
5L-phenylalanine metabolic process (GO:0006558)5.35218189
6aromatic amino acid family catabolic process (GO:0009074)4.86519860
7fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.53778172
8alpha-linolenic acid metabolic process (GO:0036109)4.47699804
9indole-containing compound catabolic process (GO:0042436)4.32680361
10indolalkylamine catabolic process (GO:0046218)4.32680361
11tryptophan catabolic process (GO:0006569)4.32680361
12tryptophan metabolic process (GO:0006568)4.25546793
13ribosome assembly (GO:0042255)4.15327878
14bile acid biosynthetic process (GO:0006699)4.14660002
15cullin deneddylation (GO:0010388)4.11473446
16biotin metabolic process (GO:0006768)4.07183043
17fatty acid elongation (GO:0030497)3.98486420
18establishment of protein localization to mitochondrial membrane (GO:0090151)3.97441311
19peroxisome fission (GO:0016559)3.94711812
20amino-acid betaine metabolic process (GO:0006577)3.89332103
21serine family amino acid catabolic process (GO:0009071)3.89230788
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.88828607
23negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.88478627
24L-serine metabolic process (GO:0006563)3.86572131
25branched-chain amino acid catabolic process (GO:0009083)3.84537354
26positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.81761770
27triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.81594215
28regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.78159604
29kynurenine metabolic process (GO:0070189)3.75390780
30valine metabolic process (GO:0006573)3.75225420
31coenzyme catabolic process (GO:0009109)3.74429668
32fatty acid beta-oxidation (GO:0006635)3.71171731
33serine family amino acid biosynthetic process (GO:0009070)3.71001235
34synapsis (GO:0007129)3.70443440
35indolalkylamine metabolic process (GO:0006586)3.69503480
36protein deneddylation (GO:0000338)3.68416344
37aromatic amino acid family metabolic process (GO:0009072)3.68410403
38glyoxylate metabolic process (GO:0046487)3.64150302
39fatty acid catabolic process (GO:0009062)3.63319946
40fatty acid oxidation (GO:0019395)3.62197622
41urea cycle (GO:0000050)3.61693250
42urea metabolic process (GO:0019627)3.61693250
43sulfur amino acid catabolic process (GO:0000098)3.59619190
44carnitine metabolic process (GO:0009437)3.58829138
45lipid oxidation (GO:0034440)3.58787164
46anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.56763955
47regulation of cellular amino acid metabolic process (GO:0006521)3.56410905
48establishment of integrated proviral latency (GO:0075713)3.55908281
49alpha-amino acid catabolic process (GO:1901606)3.55820248
50DNA double-strand break processing (GO:0000729)3.54624744
51pantothenate metabolic process (GO:0015939)3.51557223
52purine nucleobase biosynthetic process (GO:0009113)3.50908183
53regulation of triglyceride catabolic process (GO:0010896)3.50044955
54bile acid metabolic process (GO:0008206)3.48190992
55protein neddylation (GO:0045116)3.48166032
56nitrogen cycle metabolic process (GO:0071941)3.47123916
57negative regulation of ligase activity (GO:0051352)3.46828714
58negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.46828714
59chaperone-mediated protein transport (GO:0072321)3.42225684
60branched-chain amino acid metabolic process (GO:0009081)3.38663731
61cysteine metabolic process (GO:0006534)3.37192666
62monocarboxylic acid catabolic process (GO:0072329)3.36540593
63peptidyl-histidine modification (GO:0018202)3.35883107
64chromatin remodeling at centromere (GO:0031055)3.35092578
65DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.34296285
66CENP-A containing nucleosome assembly (GO:0034080)3.33284013
67triglyceride homeostasis (GO:0070328)3.32343832
68acylglycerol homeostasis (GO:0055090)3.32343832
69cellular amino acid catabolic process (GO:0009063)3.31525526
70respiratory chain complex IV assembly (GO:0008535)3.30489135
71signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.30197803
72signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.30197803
73signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.30197803
74mitochondrial respiratory chain complex assembly (GO:0033108)3.29967666
75intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.28107256
76signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.28107256
77protein complex biogenesis (GO:0070271)3.27187221
78ATP synthesis coupled proton transport (GO:0015986)3.26370287
79energy coupled proton transport, down electrochemical gradient (GO:0015985)3.26370287
80negative regulation of DNA-dependent DNA replication (GO:2000104)3.25710222
81very long-chain fatty acid metabolic process (GO:0000038)3.25357586
82positive regulation of lipoprotein lipase activity (GO:0051006)3.24996714
83positive regulation of triglyceride lipase activity (GO:0061365)3.24996714
84fatty-acyl-CoA metabolic process (GO:0035337)3.24817212
85carboxylic acid catabolic process (GO:0046395)3.24693973
86organic acid catabolic process (GO:0016054)3.24693973
87ethanol oxidation (GO:0006069)3.24086121
88positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.23819861
89fatty-acyl-CoA biosynthetic process (GO:0046949)3.22574692
90fusion of sperm to egg plasma membrane (GO:0007342)3.22399305
91L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.22131508
92lysine catabolic process (GO:0006554)3.20478708
93lysine metabolic process (GO:0006553)3.20478708
94tyrosine metabolic process (GO:0006570)3.20200316
95rRNA modification (GO:0000154)3.20094483
96exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.19836554
97serine family amino acid metabolic process (GO:0009069)3.18810038
98pseudouridine synthesis (GO:0001522)3.18787416
99high-density lipoprotein particle remodeling (GO:0034375)3.17464163
100nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.16565625
101signal transduction involved in cell cycle checkpoint (GO:0072395)3.16246810
102non-recombinational repair (GO:0000726)3.15968769
103double-strand break repair via nonhomologous end joining (GO:0006303)3.15968769
104signal transduction involved in DNA integrity checkpoint (GO:0072401)3.15881250
105signal transduction involved in DNA damage checkpoint (GO:0072422)3.15881250
106tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.15522437
107RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.15522437
108mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.15283178
109regulation of mitochondrial translation (GO:0070129)3.14653728
110axonemal dynein complex assembly (GO:0070286)3.14596377
111positive regulation of ligase activity (GO:0051351)3.14047715
112nucleobase biosynthetic process (GO:0046112)3.13927605
113cofactor catabolic process (GO:0051187)3.13547604
114epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.13426327
115acyl-CoA biosynthetic process (GO:0071616)3.11798507
116thioester biosynthetic process (GO:0035384)3.11798507
117water-soluble vitamin biosynthetic process (GO:0042364)3.10091378
118regulation of protein activation cascade (GO:2000257)3.09660340
119amine catabolic process (GO:0009310)3.09600974
120cellular biogenic amine catabolic process (GO:0042402)3.09600974
121glycine metabolic process (GO:0006544)3.09208781
122acyl-CoA metabolic process (GO:0006637)3.07730910
123thioester metabolic process (GO:0035383)3.07730910
124short-chain fatty acid metabolic process (GO:0046459)3.06888828
125long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.05519844
126protein carboxylation (GO:0018214)3.05273412
127peptidyl-glutamic acid carboxylation (GO:0017187)3.05273412
128mitochondrial respiratory chain complex I assembly (GO:0032981)3.04947047
129NADH dehydrogenase complex assembly (GO:0010257)3.04947047
130mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.04947047
131reverse cholesterol transport (GO:0043691)3.02551524
132phospholipid efflux (GO:0033700)3.02312509
133intra-S DNA damage checkpoint (GO:0031573)3.02303926
134cilium or flagellum-dependent cell motility (GO:0001539)3.01386719
135complement activation, classical pathway (GO:0006958)3.00449299
136long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.99815482
137spliceosomal snRNP assembly (GO:0000387)2.98892181
138sperm motility (GO:0030317)2.98647269
139DNA ligation (GO:0006266)2.96440426
140transcription elongation from RNA polymerase III promoter (GO:0006385)2.93384516
141termination of RNA polymerase III transcription (GO:0006386)2.93384516
142cytochrome complex assembly (GO:0017004)2.92893591
143acetyl-CoA metabolic process (GO:0006084)2.91085340
144primary alcohol catabolic process (GO:0034310)2.90588035
145complement activation, alternative pathway (GO:0006957)2.89843349
146regulation of complement activation (GO:0030449)2.89336725
147establishment of viral latency (GO:0019043)2.89112861
148small molecule catabolic process (GO:0044282)2.89043144
149histone exchange (GO:0043486)2.89006032
150rRNA methylation (GO:0031167)2.88861594
151DNA catabolic process, exonucleolytic (GO:0000738)2.88458150
152* peroxisome organization (GO:0007031)2.87769345
153negative regulation of lipase activity (GO:0060192)2.87580347
154protein targeting to mitochondrion (GO:0006626)2.85796285
155multicellular organism reproduction (GO:0032504)2.85725489
156amino acid salvage (GO:0043102)2.85527975
157L-methionine salvage (GO:0071267)2.85527975
158L-methionine biosynthetic process (GO:0071265)2.85527975
159fructose metabolic process (GO:0006000)2.85124412
160signal peptide processing (GO:0006465)2.84708313
161epithelial cilium movement (GO:0003351)2.84625607
162DNA damage response, detection of DNA damage (GO:0042769)2.84548765
163regulation of ubiquitin-protein transferase activity (GO:0051438)2.83828617
164arginine metabolic process (GO:0006525)2.83742806
165regulation of fibrinolysis (GO:0051917)2.82785781
166protein K6-linked ubiquitination (GO:0085020)2.80768548
167negative regulation of DNA recombination (GO:0045910)2.80109891
168regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.79916414
169DNA replication checkpoint (GO:0000076)2.79459402
170pyrimidine-containing compound transmembrane transport (GO:0072531)2.79444965
171respiratory electron transport chain (GO:0022904)2.78813463
172telomere maintenance via semi-conservative replication (GO:0032201)2.78750888
173ethanol metabolic process (GO:0006067)2.78713074
174complement activation (GO:0006956)2.78260288
175regulation of ligase activity (GO:0051340)2.77386477
176protein-cofactor linkage (GO:0018065)2.77312869
177regulation of glucokinase activity (GO:0033131)2.77049655
178regulation of hexokinase activity (GO:1903299)2.77049655
179mitochondrial RNA metabolic process (GO:0000959)2.76642533
180nucleotide transmembrane transport (GO:1901679)2.76533387
181electron transport chain (GO:0022900)2.75968266
182protein localization to mitochondrion (GO:0070585)2.75062831
183regulation of helicase activity (GO:0051095)2.74178431
184transcription from mitochondrial promoter (GO:0006390)2.73990800
185attachment of spindle microtubules to kinetochore (GO:0008608)2.72562772
186RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.71692838
187maturation of 5.8S rRNA (GO:0000460)2.71674253
188histone mRNA metabolic process (GO:0008334)2.70271498
189tRNA metabolic process (GO:0006399)2.69939381
190nucleotide-excision repair, DNA gap filling (GO:0006297)2.69683899
191establishment of protein localization to mitochondrion (GO:0072655)2.66191475
192transcription elongation from RNA polymerase I promoter (GO:0006362)2.65407921
193tRNA aminoacylation for protein translation (GO:0006418)2.65213167
194tRNA aminoacylation (GO:0043039)2.65118643
195amino acid activation (GO:0043038)2.65118643
196protein K11-linked ubiquitination (GO:0070979)2.63421208
197IMP biosynthetic process (GO:0006188)2.63277522
198oxidative phosphorylation (GO:0006119)2.62959035
199postreplication repair (GO:0006301)2.62018147

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.07887723
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human6.03896107
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.39128439
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.31906537
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.56715858
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.56276714
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.48762194
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.42745641
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.41813319
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.14208888
11* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.67491619
12E2F7_22180533_ChIP-Seq_HELA_Human2.56021765
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.55814916
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.46083251
15* ETS1_20019798_ChIP-Seq_JURKAT_Human2.45310769
16* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.42701229
17ZNF274_21170338_ChIP-Seq_K562_Hela2.38330215
18* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.37600775
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.25976884
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.20324732
21MYC_18555785_ChIP-Seq_MESCs_Mouse2.15124648
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.14420638
23PADI4_21655091_ChIP-ChIP_MCF-7_Human2.12761696
24FLI1_27457419_Chip-Seq_LIVER_Mouse2.12369990
25IGF1R_20145208_ChIP-Seq_DFB_Human2.01031195
26* FOXP3_21729870_ChIP-Seq_TREG_Human1.99910342
27* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.99637724
28* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.98001847
29* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96946438
30GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88046153
31EWS_26573619_Chip-Seq_HEK293_Human1.81653983
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.78714997
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.77543380
34* SRF_21415370_ChIP-Seq_HL-1_Mouse1.70890962
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.68254799
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66890495
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.64940003
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64317291
39KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.62472632
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.61853836
41TAF15_26573619_Chip-Seq_HEK293_Human1.61361578
42GATA1_22025678_ChIP-Seq_K562_Human1.61235020
43KAP1_22055183_ChIP-Seq_ESCs_Mouse1.60920570
44GABP_17652178_ChIP-ChIP_JURKAT_Human1.58564602
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.57667562
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53616836
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.50792215
48GBX2_23144817_ChIP-Seq_PC3_Human1.49112066
49VDR_22108803_ChIP-Seq_LS180_Human1.48647275
50NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.48420816
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.47366052
52MYC_18940864_ChIP-ChIP_HL60_Human1.45885390
53FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.45446510
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.43084401
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.43076461
56* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.42300550
57GABP_19822575_ChIP-Seq_HepG2_Human1.41080943
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40895563
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.40844484
60HTT_18923047_ChIP-ChIP_STHdh_Human1.40715875
61NELFA_20434984_ChIP-Seq_ESCs_Mouse1.40150872
62RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.39754764
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36790720
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.33764534
65IRF1_19129219_ChIP-ChIP_H3396_Human1.33588749
66EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.31305112
67NOTCH1_21737748_ChIP-Seq_TLL_Human1.29853850
68CREB1_15753290_ChIP-ChIP_HEK293T_Human1.29815074
69MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26060254
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24669435
71PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.24338018
72* TTF2_22483619_ChIP-Seq_HELA_Human1.21716870
73HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20866348
74* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20685871
75ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15617906
76EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.14919849
77FUS_26573619_Chip-Seq_HEK293_Human1.14715665
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12795611
79* EZH2_27294783_Chip-Seq_NPCs_Mouse1.12406147
80E2F1_21310950_ChIP-Seq_MCF-7_Human1.10725228
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10558385
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09069822
83MYC_19079543_ChIP-ChIP_MESCs_Mouse1.08904777
84* CRX_20693478_ChIP-Seq_RETINA_Mouse1.08514543
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.06327985
86ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06232903
87GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05753118
88LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05370935
89CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05071998
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04501770
91ERG_20517297_ChIP-Seq_VCAP_Human1.03746869
92BP1_19119308_ChIP-ChIP_Hs578T_Human1.03457569
93MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02978603
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02454294
95AR_21909140_ChIP-Seq_LNCAP_Human1.01464078
96RUNX1_27457419_Chip-Seq_LIVER_Mouse0.99836765
97* AR_20517297_ChIP-Seq_VCAP_Human0.99169401
98* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99012258
99SOX2_19829295_ChIP-Seq_ESCs_Human0.98737182
100NANOG_19829295_ChIP-Seq_ESCs_Human0.98737182
101TAL1_26923725_Chip-Seq_HPCs_Mouse0.98715540
102P300_19829295_ChIP-Seq_ESCs_Human0.97031320
103STAT1_17558387_ChIP-Seq_HELA_Human0.96967927
104PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96124813
105NANOG_16153702_ChIP-ChIP_HESCs_Human0.96076945
106EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95232179
107GATA3_21867929_ChIP-Seq_TH1_Mouse0.94028201
108NANOG_18555785_Chip-Seq_ESCs_Mouse0.93666566
109* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92450931
110P53_22387025_ChIP-Seq_ESCs_Mouse0.92424099
111P53_21459846_ChIP-Seq_SAOS-2_Human0.92277489
112* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.91798333
113TP53_22573176_ChIP-Seq_HFKS_Human0.91590185
114STAT3_18555785_Chip-Seq_ESCs_Mouse0.90693151
115POU5F1_16153702_ChIP-ChIP_HESCs_Human0.90080424
116ELK1_22589737_ChIP-Seq_MCF10A_Human0.89829630
117EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.89083218
118KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88557752
119GATA3_21867929_ChIP-Seq_CD8_Mouse0.88117774
120CBP_20019798_ChIP-Seq_JUKART_Human0.88062036
121IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88062036
122TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87905900
123* VDR_23849224_ChIP-Seq_CD4+_Human0.87537452
124SMAD4_21799915_ChIP-Seq_A2780_Human0.87513017
125AR_25329375_ChIP-Seq_VCAP_Human0.87350174
126* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.86974218
127SUZ12_18555785_Chip-Seq_ESCs_Mouse0.86797740
128SALL4_22934838_ChIP-ChIP_CD34+_Human0.86416132
129P300_18555785_Chip-Seq_ESCs_Mouse0.86410063
130PIAS1_25552417_ChIP-Seq_VCAP_Human0.86123693
131BCAT_22108803_ChIP-Seq_LS180_Human0.85892848
132OCT4_18555785_Chip-Seq_ESCs_Mouse0.84807646
133* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.84503607
134UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.83482047
135ESET_19884257_ChIP-Seq_ESCs_Mouse0.83298113
136AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82526030
137AUTS2_25519132_ChIP-Seq_293T-REX_Human0.81573735
138DCP1A_22483619_ChIP-Seq_HELA_Human0.80261917
139ELK1_19687146_ChIP-ChIP_HELA_Human0.80019896
140ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.79859605
141PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.79647653
142ER_23166858_ChIP-Seq_MCF-7_Human0.79384622
143SOX2_18555785_Chip-Seq_ESCs_Mouse0.78980657
144CDX2_22108803_ChIP-Seq_LS180_Human0.78427073
145PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.77980071
146SMAD1_18555785_Chip-Seq_ESCs_Mouse0.77431898
147EST1_17652178_ChIP-ChIP_JURKAT_Human0.77018624
148PHF8_20622853_ChIP-Seq_HELA_Human0.76267305
149* FOXA1_25329375_ChIP-Seq_VCAP_Human0.75729953
150* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.75729953
151CMYC_18555785_Chip-Seq_ESCs_Mouse0.75592661
152ZFX_18555785_Chip-Seq_ESCs_Mouse0.75583972
153NMYC_18555785_Chip-Seq_ESCs_Mouse0.75069310

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.39228869
2MP0005360_urolithiasis5.03030771
3MP0005365_abnormal_bile_salt5.01985368
4MP0005085_abnormal_gallbladder_physiolo4.36377596
5MP0008058_abnormal_DNA_repair4.02789957
6MP0008875_abnormal_xenobiotic_pharmacok3.80270544
7MP0003806_abnormal_nucleotide_metabolis3.68939186
8MP0008877_abnormal_DNA_methylation3.41740519
9MP0010094_abnormal_chromosome_stability2.93619938
10MP0010329_abnormal_lipoprotein_level2.89643295
11MP0003011_delayed_dark_adaptation2.88806895
12MP0000569_abnormal_digit_pigmentation2.86968105
13MP0009697_abnormal_copulation2.85140949
14MP0005410_abnormal_fertilization2.72362347
15MP0002102_abnormal_ear_morphology2.69599811
16MP0005332_abnormal_amino_acid2.64642769
17MP0003195_calcinosis2.63634364
18MP0005670_abnormal_white_adipose2.56265382
19MP0006072_abnormal_retinal_apoptosis2.36962339
20MP0003786_premature_aging2.33215531
21MP0001764_abnormal_homeostasis2.24119621
22MP0003693_abnormal_embryo_hatching2.23882122
23MP0005451_abnormal_body_composition2.22473804
24MP0004381_abnormal_hair_follicle2.21373007
25MP0004019_abnormal_vitamin_homeostasis2.20565986
26MP0004957_abnormal_blastocyst_morpholog2.20475085
27MP0002876_abnormal_thyroid_physiology2.20383542
28MP0002118_abnormal_lipid_homeostasis2.11686760
29MP0001529_abnormal_vocalization2.09197046
30MP0003186_abnormal_redox_activity2.02138443
31MP0009840_abnormal_foam_cell2.01313595
32MP0002254_reproductive_system_inflammat1.98369040
33MP0003252_abnormal_bile_duct1.96093209
34MP0003191_abnormal_cellular_cholesterol1.88661770
35MP0000609_abnormal_liver_physiology1.83832232
36MP0003718_maternal_effect1.82493994
37MP0008057_abnormal_DNA_replication1.81725569
38MP0002938_white_spotting1.79649869
39MP0010368_abnormal_lymphatic_system1.78313027
40MP0003941_abnormal_skin_development1.77493790
41MP0001666_abnormal_nutrient_absorption1.77307043
42MP0003077_abnormal_cell_cycle1.77220549
43MP0005075_abnormal_melanosome_morpholog1.76454122
44MP0003111_abnormal_nucleus_morphology1.76224162
45MP0008932_abnormal_embryonic_tissue1.70801340
46MP0008007_abnormal_cellular_replicative1.70257072
47MP0005084_abnormal_gallbladder_morpholo1.70118690
48MP0002234_abnormal_pharynx_morphology1.67190001
49MP0004215_abnormal_myocardial_fiber1.67024246
50MP0006036_abnormal_mitochondrial_physio1.66624011
51MP0002796_impaired_skin_barrier1.63426410
52MP0005319_abnormal_enzyme/_coenzyme1.58012461
53MP0001661_extended_life_span1.56246358
54MP0002638_abnormal_pupillary_reflex1.55638592
55MP0005636_abnormal_mineral_homeostasis1.47356206
56MP0001293_anophthalmia1.46436478
57MP0003868_abnormal_feces_composition1.45874596
58MP0005408_hypopigmentation1.43223088
59MP0008995_early_reproductive_senescence1.41266805
60MP0000372_irregular_coat_pigmentation1.41090671
61MP0006292_abnormal_olfactory_placode1.40838960
62MP0005647_abnormal_sex_gland1.38528710
63MP0005253_abnormal_eye_physiology1.37606078
64MP0003880_abnormal_central_pattern1.33216520
65MP0003656_abnormal_erythrocyte_physiolo1.32202181
66MP0004264_abnormal_extraembryonic_tissu1.30733489
67MP0005584_abnormal_enzyme/coenzyme_acti1.29448360
68MP0005220_abnormal_exocrine_pancreas1.27807885
69MP0008789_abnormal_olfactory_epithelium1.25510531
70MP0001929_abnormal_gametogenesis1.24163731
71MP0009643_abnormal_urine_homeostasis1.24156301
72MP0001188_hyperpigmentation1.22417849
73MP0002132_abnormal_respiratory_system1.20062227
74MP0002163_abnormal_gland_morphology1.19676193
75MP0000358_abnormal_cell_content/1.18905503
76MP0003121_genomic_imprinting1.17708164
77MP0003698_abnormal_male_reproductive1.17449118
78MP0002160_abnormal_reproductive_system1.14407773
79MP0004130_abnormal_muscle_cell1.13812561
80MP0002090_abnormal_vision1.13596516
81MP0004043_abnormal_pH_regulation1.13336464
82MP0000631_abnormal_neuroendocrine_gland1.10711408
83MP0005395_other_phenotype1.09575576
84MP0003724_increased_susceptibility_to1.09179892
85MP0003787_abnormal_imprinting1.06569118
86MP0003937_abnormal_limbs/digits/tail_de1.06387730
87MP0004782_abnormal_surfactant_physiolog1.06336456
88MP0005379_endocrine/exocrine_gland_phen1.04832414
89MP0005083_abnormal_biliary_tract1.02225031
90MP0001879_abnormal_lymphatic_vessel1.01603043
91MP0004147_increased_porphyrin_level1.01441553
92MP0000516_abnormal_urinary_system0.99357824
93MP0005367_renal/urinary_system_phenotyp0.99357824
94MP0005535_abnormal_body_temperature0.99050612
95MP0002971_abnormal_brown_adipose0.98824056
96MP0009379_abnormal_foot_pigmentation0.98466086
97MP0002138_abnormal_hepatobiliary_system0.94512098
98MP0003950_abnormal_plasma_membrane0.93961340
99MP0005645_abnormal_hypothalamus_physiol0.92750356
100MP0009780_abnormal_chondrocyte_physiolo0.91300047
101MP0002078_abnormal_glucose_homeostasis0.90152796
102MP0000647_abnormal_sebaceous_gland0.89639759
103MP0002751_abnormal_autonomic_nervous0.88658525
104MP0006276_abnormal_autonomic_nervous0.86664666
105MP0003890_abnormal_embryonic-extraembry0.85013898
106MP0001944_abnormal_pancreas_morphology0.84316439
107MP0005334_abnormal_fat_pad0.83928404
108MP0005187_abnormal_penis_morphology0.83766107
109MP0003137_abnormal_impulse_conducting0.83386309
110MP0006054_spinal_hemorrhage0.83265839
111MP0003567_abnormal_fetal_cardiomyocyte0.82872806
112MP0002233_abnormal_nose_morphology0.82552488
113MP0001730_embryonic_growth_arrest0.82092091
114MP0006035_abnormal_mitochondrial_morpho0.81699859
115MP0002736_abnormal_nociception_after0.81209498
116MP0002177_abnormal_outer_ear0.80865631
117MP0000598_abnormal_liver_morphology0.80521869
118MP0009046_muscle_twitch0.80311412
119MP0005389_reproductive_system_phenotype0.79562430
120MP0001119_abnormal_female_reproductive0.79472567
121MP0005376_homeostasis/metabolism_phenot0.78797417
122MP0002060_abnormal_skin_morphology0.78790320
123MP0003122_maternal_imprinting0.77784273
124MP0005266_abnormal_metabolism0.77766846
125MP0005666_abnormal_adipose_tissue0.77338451
126MP0000427_abnormal_hair_cycle0.77164809
127MP0000383_abnormal_hair_follicle0.76643851
128MP0009642_abnormal_blood_homeostasis0.76126039
129MP0000013_abnormal_adipose_tissue0.76057193
130MP0010678_abnormal_skin_adnexa0.75586640
131MP0001697_abnormal_embryo_size0.74892872
132MP0000230_abnormal_systemic_arterial0.72280764
133MP0002210_abnormal_sex_determination0.71843696
134MP0002161_abnormal_fertility/fecundity0.71654722
135MP0005330_cardiomyopathy0.71176192
136MP0002095_abnormal_skin_pigmentation0.68647324
137MP0001191_abnormal_skin_condition0.67779991
138MP0000653_abnormal_sex_gland0.67676137
139MP0004084_abnormal_cardiac_muscle0.67566431
140MP0002295_abnormal_pulmonary_circulatio0.66163408
141MP0002693_abnormal_pancreas_physiology0.65707134
142MP0003953_abnormal_hormone_level0.65078992
143MP0009115_abnormal_fat_cell0.65041459
144MP0005646_abnormal_pituitary_gland0.64051313
145MP0002837_dystrophic_cardiac_calcinosis0.63539001
146MP0003690_abnormal_glial_cell0.63045029
147MP0000639_abnormal_adrenal_gland0.62848651
148MP0003136_yellow_coat_color0.61957198
149MP0001177_atelectasis0.61590029
150MP0008260_abnormal_autophagy0.61212469
151MP0009764_decreased_sensitivity_to0.60468021
152MP0008469_abnormal_protein_level0.59152582
153MP0001765_abnormal_ion_homeostasis0.58137691
154MP0001145_abnormal_male_reproductive0.57161773
155MP0000678_abnormal_parathyroid_gland0.56465317
156MP0001881_abnormal_mammary_gland0.54605086
157MP0001984_abnormal_olfaction0.53726597
158MP0005551_abnormal_eye_electrophysiolog0.53624175
159MP0002822_catalepsy0.52780282
160MP0001756_abnormal_urination0.52089308
161MP0001853_heart_inflammation0.51968233
162MP0005448_abnormal_energy_balance0.51531827

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.35936901
2Hyperglycinemia (HP:0002154)4.55285478
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.43716199
4Hyperglycinuria (HP:0003108)4.34535870
5Abnormality of serine family amino acid metabolism (HP:0010894)4.16966256
6Abnormality of glycine metabolism (HP:0010895)4.16966256
7Prolonged partial thromboplastin time (HP:0003645)4.08533146
8Intrahepatic cholestasis (HP:0001406)3.92127112
9Hyperammonemia (HP:0001987)3.71005014
10Methylmalonic acidemia (HP:0002912)3.70709007
11Hyperlipoproteinemia (HP:0010980)3.68650016
12Increased serum pyruvate (HP:0003542)3.68531545
13Abnormality of monocarboxylic acid metabolism (HP:0010996)3.59154677
14Increased CSF lactate (HP:0002490)3.58930172
15Hypobetalipoproteinemia (HP:0003563)3.54767226
16Acute necrotizing encephalopathy (HP:0006965)3.54254983
17Xanthomatosis (HP:0000991)3.52059126
18Abnormal respiratory motile cilium physiology (HP:0012261)3.49945017
19Dynein arm defect of respiratory motile cilia (HP:0012255)3.48513927
20Absent/shortened dynein arms (HP:0200106)3.48513927
21Abnormality of glycolysis (HP:0004366)3.41946998
22Reduced antithrombin III activity (HP:0001976)3.38655279
23Abnormality of serum amino acid levels (HP:0003112)3.33063794
24Deep venous thrombosis (HP:0002625)3.28703801
25Mitochondrial inheritance (HP:0001427)3.21913249
26Progressive macrocephaly (HP:0004481)3.20654643
27Increased hepatocellular lipid droplets (HP:0006565)3.20242070
28Abnormal mitochondria in muscle tissue (HP:0008316)3.18987448
29Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.17111554
303-Methylglutaconic aciduria (HP:0003535)3.16911367
31Hypoglycemic coma (HP:0001325)3.16600284
32Abnormal ciliary motility (HP:0012262)3.15736687
33Ketosis (HP:0001946)3.15688109
34Hypolipoproteinemia (HP:0010981)3.13636354
35Medial flaring of the eyebrow (HP:0010747)3.08223637
36Hypoalphalipoproteinemia (HP:0003233)3.08191943
37Dicarboxylic aciduria (HP:0003215)3.00487529
38Abnormality of dicarboxylic acid metabolism (HP:0010995)3.00487529
39Abnormality of fatty-acid metabolism (HP:0004359)2.95833269
40Type I transferrin isoform profile (HP:0003642)2.93399970
41Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.93023217
42Rhinitis (HP:0012384)2.91698902
43Abnormality of the intrinsic pathway (HP:0010989)2.89197235
44Lipid accumulation in hepatocytes (HP:0006561)2.88764301
45Generalized aminoaciduria (HP:0002909)2.87505646
46Abnormal respiratory motile cilium morphology (HP:0005938)2.83669370
47Abnormal respiratory epithelium morphology (HP:0012253)2.83669370
48Renal Fanconi syndrome (HP:0001994)2.82048223
49Abnormality of the common coagulation pathway (HP:0010990)2.78422633
50Increased serum lactate (HP:0002151)2.71153322
51Conjugated hyperbilirubinemia (HP:0002908)2.70889904
52Congenital primary aphakia (HP:0007707)2.65203296
53Spontaneous abortion (HP:0005268)2.63724002
54Lethargy (HP:0001254)2.63598785
55Abnormality of the anterior horn cell (HP:0006802)2.62229964
56Degeneration of anterior horn cells (HP:0002398)2.62229964
57Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.56808992
58Abnormality of alanine metabolism (HP:0010916)2.56808992
59Hyperalaninemia (HP:0003348)2.56808992
60Lactic acidosis (HP:0003128)2.55015833
61Nephrogenic diabetes insipidus (HP:0009806)2.52429106
62Abnormality of vitamin B metabolism (HP:0004340)2.51125675
63Abnormal glycosylation (HP:0012345)2.48840165
64Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.48840165
65Abnormal protein N-linked glycosylation (HP:0012347)2.48840165
66Abnormal protein glycosylation (HP:0012346)2.48840165
67Renal cortical cysts (HP:0000803)2.48538294
68* Brushfield spots (HP:0001088)2.48001670
69Gait imbalance (HP:0002141)2.47649990
70Fat malabsorption (HP:0002630)2.47436984
71Complement deficiency (HP:0004431)2.45716378
72Cerebral edema (HP:0002181)2.45438116
73Abnormality of the labia minora (HP:0012880)2.41256968
74Metabolic acidosis (HP:0001942)2.40490217
75Tubulointerstitial nephritis (HP:0001970)2.38274600
76Abnormality of the axillary hair (HP:0100134)2.37590438
77Abnormality of secondary sexual hair (HP:0009888)2.37590438
78Abnormality of aspartate family amino acid metabolism (HP:0010899)2.37399805
79Hepatic necrosis (HP:0002605)2.35858171
80Hyperbilirubinemia (HP:0002904)2.35722358
81Abnormality of the vitamin B12 metabolism (HP:0004341)2.35097136
82Abnormality of methionine metabolism (HP:0010901)2.32666061
83Gout (HP:0001997)2.31917173
84Delayed CNS myelination (HP:0002188)2.30994693
85Chronic bronchitis (HP:0004469)2.30950201
86Pancreatic islet-cell hyperplasia (HP:0004510)2.29982594
87Enlarged kidneys (HP:0000105)2.29471505
88Colon cancer (HP:0003003)2.28875791
89Ketoacidosis (HP:0001993)2.26028015
90Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.25949522
91Decreased activity of mitochondrial respiratory chain (HP:0008972)2.25949522
92Abnormality of pyrimidine metabolism (HP:0004353)2.22027975
93Hypoglycemic seizures (HP:0002173)2.20698142
94Genital tract atresia (HP:0001827)2.20324365
95Epidermoid cyst (HP:0200040)2.16810436
96Pancreatitis (HP:0001733)2.16194445
97Respiratory failure (HP:0002878)2.15040002
98Hyperinsulinemic hypoglycemia (HP:0000825)2.14668827
99Abnormality of nucleobase metabolism (HP:0010932)2.12877427
100Nephronophthisis (HP:0000090)2.12739035
101Vomiting (HP:0002013)2.11315167
102Abnormality of purine metabolism (HP:0004352)2.08302153
103Steatorrhea (HP:0002570)2.07226602
104Abnormality of midbrain morphology (HP:0002418)2.06992872
105Molar tooth sign on MRI (HP:0002419)2.06992872
106Symptomatic seizures (HP:0011145)2.05864790
107True hermaphroditism (HP:0010459)2.05776116
108Vaginal atresia (HP:0000148)2.04421353
109Methylmalonic aciduria (HP:0012120)2.04254658
110Acute encephalopathy (HP:0006846)2.03716716
111CNS demyelination (HP:0007305)2.03587593
112Abnormality of chromosome stability (HP:0003220)2.03235066
113Neoplasm of the adrenal gland (HP:0100631)2.02935070
114Abnormality of sulfur amino acid metabolism (HP:0004339)2.02931834
115Abnormal spermatogenesis (HP:0008669)2.02842361
116Bile duct proliferation (HP:0001408)2.00226122
117Abnormal biliary tract physiology (HP:0012439)2.00226122
118Meckel diverticulum (HP:0002245)1.98222915
119Pancreatic fibrosis (HP:0100732)1.98007394
120Joint hemorrhage (HP:0005261)1.95131611
121Hypothermia (HP:0002045)1.93040260
122Increased intramyocellular lipid droplets (HP:0012240)1.91702775
123J-shaped sella turcica (HP:0002680)1.91498545
124Pancreatic cysts (HP:0001737)1.90493003
125Volvulus (HP:0002580)1.90108553
126Confusion (HP:0001289)1.89970345
127Chromsome breakage (HP:0040012)1.89964442
128Metaphyseal dysplasia (HP:0100255)1.88363837
129Abnormality of glutamine family amino acid metabolism (HP:0010902)1.88315386
130Limb hypertonia (HP:0002509)1.88253769
131Abnormality of renal resorption (HP:0011038)1.87549453
132Exercise intolerance (HP:0003546)1.87461964
133Abnormality of the renal cortex (HP:0011035)1.86914724
134Irritability (HP:0000737)1.85978990
135Spastic paraparesis (HP:0002313)1.85597569
136Elevated hepatic transaminases (HP:0002910)1.85098678
137Abnormality of the ileum (HP:0001549)1.84697871
138Microretrognathia (HP:0000308)1.84442551
139Hyperuricemia (HP:0002149)1.83905309
140Increased purine levels (HP:0004368)1.83905309
141Proximal tubulopathy (HP:0000114)1.82585907
142Abnormality of endocrine pancreas physiology (HP:0012093)1.82487723
143Abnormality of the pancreatic islet cells (HP:0006476)1.82487723
144Abnormal hemoglobin (HP:0011902)1.81087994
145Abnormality of urine glucose concentration (HP:0011016)1.80999079
146Glycosuria (HP:0003076)1.80999079
147Aplasia/Hypoplasia of the uvula (HP:0010293)1.79500836
148Prominent metopic ridge (HP:0005487)1.78744972
149* Epiphyseal stippling (HP:0010655)1.78500218
150Hypertriglyceridemia (HP:0002155)1.78282249
151Azoospermia (HP:0000027)1.77368902
152Abnormality of vitamin metabolism (HP:0100508)1.76374663
153Hepatocellular necrosis (HP:0001404)1.75980763
154Megaloblastic anemia (HP:0001889)1.75934714
155Abnormality of lateral ventricle (HP:0030047)1.75268159
156Hypercholesterolemia (HP:0003124)1.74542411
157Abnormality of the renal medulla (HP:0100957)1.74051581
158Gonadotropin excess (HP:0000837)1.71494301
159Neuroendocrine neoplasm (HP:0100634)1.71309364
160Intestinal atresia (HP:0011100)1.68374894

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.94060524
2PDK33.33493887
3PDK43.33493887
4MAP4K23.09495265
5BUB13.03269258
6PDK22.93881177
7TRIM282.72123815
8NUAK12.56024102
9BRSK22.53457919
10ARAF2.44057990
11CDC72.40477120
12AKT32.35721634
13WNK32.27291141
14PINK12.24676383
15EIF2AK32.23566953
16NEK12.22334139
17STK242.15515975
18PLK42.10519767
19TNIK2.06844137
20MAP3K122.06617888
21PLK31.98977385
22TSSK61.98349741
23ZAK1.95519115
24IRAK31.93023658
25PIM21.90349387
26NME21.83803978
27TAOK31.79103940
28VRK21.76728509
29ERBB31.67250057
30WEE11.62603412
31BRAF1.61742018
32MAPK151.56588535
33BCR1.56105077
34FRK1.51771459
35MKNK21.51112047
36CASK1.48147094
37CDK81.47138848
38TIE11.46018077
39MKNK11.43355755
40INSRR1.41519518
41EIF2AK11.40426513
42BMPR21.36751445
43TTK1.36295028
44GRK51.36274670
45CCNB11.35249256
46PTK2B1.32621303
47SRPK11.31522628
48NEK61.26033329
49PLK21.23547438
50CSF1R1.23373513
51FLT31.22112125
52STK38L1.16753585
53NME11.16324676
54MAP2K61.14716695
55KDR1.13002772
56ERBB41.12860310
57MAP2K71.11552415
58PIK3CA1.10010028
59VRK11.09586144
60PLK11.07945001
61CSNK1G31.05560537
62CDK31.05101023
63PBK1.03923753
64TAF11.03624367
65PIK3CG1.01375274
66PNCK0.97534315
67STK160.96668703
68ABL20.95269266
69NLK0.94919778
70EIF2AK20.91072772
71CSNK1A1L0.86137012
72MET0.85536703
73MUSK0.83480539
74PASK0.83087378
75MAPK70.81689413
76BMPR1B0.79295142
77TEC0.78724502
78RPS6KA40.75449241
79MAP3K60.74923842
80MAP3K40.74839945
81IRAK10.74580514
82ERN10.72334317
83LIMK10.70793594
84STK390.70730643
85MINK10.69828571
86DYRK20.69354185
87TESK10.69272404
88KIT0.67964517
89STK30.67932749
90DYRK30.67215681
91MOS0.65929625
92WNK40.65657494
93MAP2K40.65647276
94ADRBK20.65100176
95ATM0.62850897
96GRK10.62593066
97FGFR40.60489761
98BRSK10.59981013
99ATR0.59822686
100CLK10.59248595
101PRKCE0.58878766
102SIK10.58765631
103MAPK120.58163943
104AURKB0.57356594
105ACVR1B0.57159412
106IRAK40.56935978
107MST1R0.56373023
108OXSR10.55920117
109LATS10.55851464
110MAPKAPK50.55836603
111STK40.54832723
112MYLK0.53781576
113IRAK20.51994581
114CAMK2G0.51020052
115TGFBR20.50139514
116IGF1R0.49927314
117MAPK110.49595921
118MAPK130.48720686
119CHEK10.48383288
120CSNK1G20.46300960
121CSNK2A20.45865158
122PAK30.45692977
123NEK90.45352050
124ZAP700.45334983
125PRKACG0.44723833
126EPHA40.44287954
127MAPK40.43971797
128MST40.42660596
129MAP3K50.42389993
130DAPK10.42274860
131CAMKK20.41844024
132CSNK1G10.41505902
133PRKAA20.40484433
134GRK70.40227922
135FGFR10.40157463
136PRKCG0.39930534
137CHEK20.39243804
138TGFBR10.37952928
139PRKG20.37580372
140SCYL20.37087131
141PRKACA0.36152139
142FGFR20.35998880
143PRKAA10.35748699
144MARK30.35463232
145MAP3K30.35452498
146RPS6KA50.34760508
147FER0.34726820
148CSNK1A10.34628770
149IKBKE0.33875616
150CSNK2A10.33472878
151CSNK1E0.33422105
152OBSCN0.30346569
153PHKG10.29259559
154PHKG20.29259559
155TLK10.28054694

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.26851432
2Vitamin B6 metabolism_Homo sapiens_hsa007503.04837780
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.66078442
4Fatty acid degradation_Homo sapiens_hsa000712.64490019
5Propanoate metabolism_Homo sapiens_hsa006402.62160264
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.59528980
7Mismatch repair_Homo sapiens_hsa034302.54560889
8Fatty acid elongation_Homo sapiens_hsa000622.43134443
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.39273022
10Homologous recombination_Homo sapiens_hsa034402.38420844
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.33920241
12* Peroxisome_Homo sapiens_hsa041462.24876748
13Fatty acid metabolism_Homo sapiens_hsa012122.19214528
14Folate biosynthesis_Homo sapiens_hsa007902.15019232
15Tryptophan metabolism_Homo sapiens_hsa003802.07755894
16DNA replication_Homo sapiens_hsa030302.06145606
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.99235796
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.98825731
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.98001324
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.94428551
21Protein export_Homo sapiens_hsa030601.91198526
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.90115110
23PPAR signaling pathway_Homo sapiens_hsa033201.84952121
24beta-Alanine metabolism_Homo sapiens_hsa004101.84445977
25Nitrogen metabolism_Homo sapiens_hsa009101.80837112
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.80753655
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.77372437
28Histidine metabolism_Homo sapiens_hsa003401.76175529
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.74294564
30Butanoate metabolism_Homo sapiens_hsa006501.72756038
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.72478358
32Arginine biosynthesis_Homo sapiens_hsa002201.72279552
33Nucleotide excision repair_Homo sapiens_hsa034201.70988972
34Retinol metabolism_Homo sapiens_hsa008301.70936949
35Sulfur metabolism_Homo sapiens_hsa009201.69887639
36RNA transport_Homo sapiens_hsa030131.68797706
37Fanconi anemia pathway_Homo sapiens_hsa034601.67228649
38Steroid biosynthesis_Homo sapiens_hsa001001.66790922
39Complement and coagulation cascades_Homo sapiens_hsa046101.66500050
40Pyruvate metabolism_Homo sapiens_hsa006201.64151420
41Chemical carcinogenesis_Homo sapiens_hsa052041.61704944
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.47948274
43Spliceosome_Homo sapiens_hsa030401.47871103
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.43850163
45Base excision repair_Homo sapiens_hsa034101.40909332
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.36738284
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34149364
48Selenocompound metabolism_Homo sapiens_hsa004501.24024493
49Pentose phosphate pathway_Homo sapiens_hsa000301.21877546
50Phenylalanine metabolism_Homo sapiens_hsa003601.19154649
51Glycerolipid metabolism_Homo sapiens_hsa005611.18692665
52Ribosome_Homo sapiens_hsa030101.15132594
53Vitamin digestion and absorption_Homo sapiens_hsa049771.15111708
54Tyrosine metabolism_Homo sapiens_hsa003501.14653629
55Caffeine metabolism_Homo sapiens_hsa002321.12100103
56Glutathione metabolism_Homo sapiens_hsa004801.10649360
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09143101
58Carbon metabolism_Homo sapiens_hsa012001.08562114
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.08059634
60Linoleic acid metabolism_Homo sapiens_hsa005911.06905192
61Fatty acid biosynthesis_Homo sapiens_hsa000611.06711740
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05985887
63Proteasome_Homo sapiens_hsa030501.04184450
64Arginine and proline metabolism_Homo sapiens_hsa003300.99770090
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.97938171
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95651738
67Fat digestion and absorption_Homo sapiens_hsa049750.94962442
68RNA polymerase_Homo sapiens_hsa030200.93510540
69Metabolic pathways_Homo sapiens_hsa011000.93015205
70Biosynthesis of amino acids_Homo sapiens_hsa012300.91188386
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90996904
72Arachidonic acid metabolism_Homo sapiens_hsa005900.89803818
73Regulation of autophagy_Homo sapiens_hsa041400.88179675
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.85563953
75Starch and sucrose metabolism_Homo sapiens_hsa005000.84141231
76Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81906217
77Sphingolipid metabolism_Homo sapiens_hsa006000.81652546
78Cell cycle_Homo sapiens_hsa041100.80609706
79ABC transporters_Homo sapiens_hsa020100.80184293
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78240017
81Oocyte meiosis_Homo sapiens_hsa041140.73193806
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72624437
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72015293
84Staphylococcus aureus infection_Homo sapiens_hsa051500.71123566
85Pyrimidine metabolism_Homo sapiens_hsa002400.70803189
86Basal transcription factors_Homo sapiens_hsa030220.69567118
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68540143
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66803731
89Oxidative phosphorylation_Homo sapiens_hsa001900.62988181
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.61560508
91Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60995697
92Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.60501729
93Phototransduction_Homo sapiens_hsa047440.55298179
94mRNA surveillance pathway_Homo sapiens_hsa030150.54247661
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53576679
96p53 signaling pathway_Homo sapiens_hsa041150.53338848
97Cardiac muscle contraction_Homo sapiens_hsa042600.53200990
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52313391
99Fructose and mannose metabolism_Homo sapiens_hsa000510.52173905
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.51119495
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.48326490
102Collecting duct acid secretion_Homo sapiens_hsa049660.47952037
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46766173
104Sulfur relay system_Homo sapiens_hsa041220.45191710
105Bile secretion_Homo sapiens_hsa049760.43227652
106Purine metabolism_Homo sapiens_hsa002300.42895711
107Ether lipid metabolism_Homo sapiens_hsa005650.42471404
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41037101
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33411575
110Huntingtons disease_Homo sapiens_hsa050160.32014271
111Circadian rhythm_Homo sapiens_hsa047100.30797557
112Non-homologous end-joining_Homo sapiens_hsa034500.30312883
113Parkinsons disease_Homo sapiens_hsa050120.29970098
114One carbon pool by folate_Homo sapiens_hsa006700.23769767
115RNA degradation_Homo sapiens_hsa030180.23314230
116Galactose metabolism_Homo sapiens_hsa000520.16494794
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.12927237
118N-Glycan biosynthesis_Homo sapiens_hsa005100.11945303
119Alzheimers disease_Homo sapiens_hsa050100.11708101
120Glucagon signaling pathway_Homo sapiens_hsa049220.09222035

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »