PEX6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) family of ATPases. This member is a predominantly cytoplasmic protein, which plays a direct role in peroxisomal protein import and is required for PTS1 (peroxisomal targeting signal 1, a C-terminal tripeptide of the sequence ser-lys-leu) receptor activity. Mutations in this gene cause peroxisome biogenesis disorders of complementation group 4 and complementation group 6. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.87905311
2L-phenylalanine catabolic process (GO:0006559)6.87905311
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.74021860
4L-phenylalanine metabolic process (GO:0006558)6.74021860
5aromatic amino acid family catabolic process (GO:0009074)5.95965236
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.75008946
7alpha-linolenic acid metabolic process (GO:0036109)5.63933342
8kynurenine metabolic process (GO:0070189)5.38283095
9glyoxylate metabolic process (GO:0046487)5.34720538
10indole-containing compound catabolic process (GO:0042436)5.23249836
11indolalkylamine catabolic process (GO:0046218)5.23249836
12tryptophan catabolic process (GO:0006569)5.23249836
13bile acid biosynthetic process (GO:0006699)5.21443887
14sulfur amino acid catabolic process (GO:0000098)5.19678303
15lysine catabolic process (GO:0006554)5.17164115
16lysine metabolic process (GO:0006553)5.17164115
17cysteine metabolic process (GO:0006534)5.11791815
18urea cycle (GO:0000050)5.02859532
19urea metabolic process (GO:0019627)5.02859532
20negative regulation of fibrinolysis (GO:0051918)4.94735812
21fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.91212594
22tryptophan metabolic process (GO:0006568)4.87939227
23high-density lipoprotein particle remodeling (GO:0034375)4.79290699
24negative regulation of erythrocyte differentiation (GO:0045647)4.76795618
25complement activation, alternative pathway (GO:0006957)4.74991298
26regulation of triglyceride catabolic process (GO:0010896)4.69470406
27peptidyl-glutamic acid carboxylation (GO:0017187)4.67332787
28protein carboxylation (GO:0018214)4.67332787
29nitrogen cycle metabolic process (GO:0071941)4.61050144
30regulation of protein activation cascade (GO:2000257)4.60157987
31serine family amino acid catabolic process (GO:0009071)4.54203075
32regulation of fibrinolysis (GO:0051917)4.53354660
33amino-acid betaine metabolic process (GO:0006577)4.49940784
34bile acid metabolic process (GO:0008206)4.45125632
35negative regulation of sterol transport (GO:0032372)4.39508030
36negative regulation of cholesterol transport (GO:0032375)4.39508030
37homocysteine metabolic process (GO:0050667)4.33983360
38regulation of complement activation (GO:0030449)4.32170773
39aromatic amino acid family metabolic process (GO:0009072)4.29502756
40regulation of cholesterol homeostasis (GO:2000188)4.28866658
41alpha-amino acid catabolic process (GO:1901606)4.27642337
42reverse cholesterol transport (GO:0043691)4.23622651
43ethanol oxidation (GO:0006069)4.21130913
44glutamate metabolic process (GO:0006536)4.21090004
45regulation of cholesterol esterification (GO:0010872)4.15990077
46acylglycerol homeostasis (GO:0055090)4.12830945
47triglyceride homeostasis (GO:0070328)4.12830945
48tyrosine metabolic process (GO:0006570)4.12568466
49protein-lipid complex remodeling (GO:0034368)4.11350553
50macromolecular complex remodeling (GO:0034367)4.11350553
51plasma lipoprotein particle remodeling (GO:0034369)4.11350553
522-oxoglutarate metabolic process (GO:0006103)4.10716633
53plasma lipoprotein particle clearance (GO:0034381)4.09729498
54cellular ketone body metabolic process (GO:0046950)4.07767022
55cellular modified amino acid catabolic process (GO:0042219)4.03222418
56cellular amino acid catabolic process (GO:0009063)4.02513892
57acetyl-CoA metabolic process (GO:0006084)4.00445417
58phospholipid efflux (GO:0033700)4.00216956
59dicarboxylic acid biosynthetic process (GO:0043650)3.98053109
60glycine metabolic process (GO:0006544)3.96350860
61short-chain fatty acid metabolic process (GO:0046459)3.93304995
62coenzyme catabolic process (GO:0009109)3.92589512
63aspartate family amino acid catabolic process (GO:0009068)3.90189640
64mannose metabolic process (GO:0006013)3.89252318
65positive regulation of fatty acid beta-oxidation (GO:0032000)3.88494919
66fatty acid beta-oxidation (GO:0006635)3.84627644
67serine family amino acid metabolic process (GO:0009069)3.79946131
68drug catabolic process (GO:0042737)3.77315105
69fatty acid oxidation (GO:0019395)3.74944954
70regulation of fatty acid beta-oxidation (GO:0031998)3.74741425
71positive regulation of lipid catabolic process (GO:0050996)3.74536845
72valine metabolic process (GO:0006573)3.68200934
73lipid oxidation (GO:0034440)3.66696799
74fatty acid catabolic process (GO:0009062)3.66102706
75monocarboxylic acid catabolic process (GO:0072329)3.65568696
76organic acid catabolic process (GO:0016054)3.64434877
77carboxylic acid catabolic process (GO:0046395)3.64434877
78plasma lipoprotein particle assembly (GO:0034377)3.63814129
79bile acid and bile salt transport (GO:0015721)3.63696514
80Golgi transport vesicle coating (GO:0048200)3.62865311
81COPI coating of Golgi vesicle (GO:0048205)3.62865311
82benzene-containing compound metabolic process (GO:0042537)3.62146968
83indolalkylamine metabolic process (GO:0006586)3.58321738
84cholesterol efflux (GO:0033344)3.57931907
85negative regulation of lipase activity (GO:0060192)3.56736230
86positive regulation of triglyceride metabolic process (GO:0090208)3.55401363
87drug transmembrane transport (GO:0006855)3.52356428
88carnitine metabolic process (GO:0009437)3.51999283
89ketone body metabolic process (GO:1902224)3.51815726
90imidazole-containing compound metabolic process (GO:0052803)3.50032828
91phospholipid homeostasis (GO:0055091)3.50008938
92positive regulation of triglyceride lipase activity (GO:0061365)3.47306914
93positive regulation of lipoprotein lipase activity (GO:0051006)3.47306914
94serine family amino acid biosynthetic process (GO:0009070)3.46109418
95arginine metabolic process (GO:0006525)3.43274821
96cholesterol homeostasis (GO:0042632)3.42794717
97protein-lipid complex assembly (GO:0065005)3.41556979
98regulation of cholesterol metabolic process (GO:0090181)3.40819265
99sterol homeostasis (GO:0055092)3.38103562
100complement activation, classical pathway (GO:0006958)3.35668677
101amine catabolic process (GO:0009310)3.35405995
102cellular biogenic amine catabolic process (GO:0042402)3.35405995
103cellular glucuronidation (GO:0052695)3.34652765
104fatty acid transmembrane transport (GO:1902001)3.32454185
105regulation of ARF protein signal transduction (GO:0032012)3.26212566
106negative regulation of cell size (GO:0045792)3.25349479
107retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.22474681
108cytoskeletal anchoring at plasma membrane (GO:0007016)3.15170134
109antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.15047214
110regulation of extracellular matrix disassembly (GO:0010715)3.14342057
111regulation of ARF GTPase activity (GO:0032312)3.10432032
112proline biosynthetic process (GO:0006561)3.10369703
113protein retention in ER lumen (GO:0006621)3.08359431
114antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.05450961
115synaptic vesicle docking involved in exocytosis (GO:0016081)3.04934093
116antigen processing and presentation of endogenous antigen (GO:0019883)3.04933530
117proline metabolic process (GO:0006560)2.92599817
118negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.91893648
119regulation of cholesterol biosynthetic process (GO:0045540)2.88836154
120ethanol metabolic process (GO:0006067)2.85946007
121detection of bacterium (GO:0016045)2.85784876
122maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.84135000
123barbed-end actin filament capping (GO:0051016)2.82215134
124regulation of early endosome to late endosome transport (GO:2000641)2.79592854
125activation of Rac GTPase activity (GO:0032863)2.73087268
126focal adhesion assembly (GO:0048041)2.72935975
127cell-substrate adherens junction assembly (GO:0007045)2.72935975
128basement membrane organization (GO:0071711)2.71756408
129detection of other organism (GO:0098543)2.69267722
130peptidyl-tyrosine autophosphorylation (GO:0038083)2.68983156
131epoxygenase P450 pathway (GO:0019373)2.68963750
132glutamine family amino acid biosynthetic process (GO:0009084)2.67496394
133pentose-phosphate shunt (GO:0006098)2.67298492
134negative regulation of fatty acid transport (GO:2000192)2.64511495
135NADH metabolic process (GO:0006734)2.64486155
136adherens junction assembly (GO:0034333)2.63627579
137regulation of glucose import in response to insulin stimulus (GO:2001273)2.62618476
138apoptotic process involved in morphogenesis (GO:0060561)2.62199615
139stress fiber assembly (GO:0043149)2.61295471
140protein localization to endosome (GO:0036010)2.59965503
141regulation of extracellular matrix organization (GO:1903053)2.59128781
142cell volume homeostasis (GO:0006884)2.58931395
143positive regulation of extracellular matrix organization (GO:1903055)2.58193287
144positive regulation of histone deacetylation (GO:0031065)2.54045433
145maternal placenta development (GO:0001893)2.53778028
146cell-cell junction maintenance (GO:0045217)2.53423234
147positive regulation of protein dephosphorylation (GO:0035307)2.51584795
148epithelial cell differentiation involved in prostate gland development (GO:0060742)2.49735612
149positive regulation of receptor recycling (GO:0001921)2.49083160
150semaphorin-plexin signaling pathway (GO:0071526)2.47521046
151receptor recycling (GO:0001881)2.45979375
152positive thymic T cell selection (GO:0045059)2.45022934
153glucose catabolic process (GO:0006007)2.44404809
154negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.40298648
155negative regulation of cell killing (GO:0031342)2.40298648
156cell-substrate junction assembly (GO:0007044)2.40009521
157detection of external biotic stimulus (GO:0098581)2.37627825
158positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.37392449
159response to laminar fluid shear stress (GO:0034616)2.35938831
160activation of JUN kinase activity (GO:0007257)2.35267780
161atrioventricular valve morphogenesis (GO:0003181)2.34242335
162positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.32580844
163response to muramyl dipeptide (GO:0032495)2.31437238
164regulation of apoptotic cell clearance (GO:2000425)2.31346205
165modulation by symbiont of host cellular process (GO:0044068)2.31316958
166signal complex assembly (GO:0007172)2.30962049
167activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.29752109
168regulation of fatty acid biosynthetic process (GO:0042304)2.28642504
169thymic T cell selection (GO:0045061)2.27858856
170oxaloacetate metabolic process (GO:0006107)2.26631191
171creatine metabolic process (GO:0006600)2.26400952
172UV protection (GO:0009650)2.21024560
173negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.20995878
174regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.20277580
175actin filament polymerization (GO:0030041)2.20258275
176positive regulation of blood vessel endothelial cell migration (GO:0043536)2.19762476
177fructose metabolic process (GO:0006000)2.18713726
178activation of MAPKKK activity (GO:0000185)2.18676849
179G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.18259999
180germinal center formation (GO:0002467)2.18253984
181positive regulation of Rap GTPase activity (GO:0032854)2.18221598
182modulation by virus of host process (GO:0019054)2.17871039

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.94713596
2RXR_22158963_ChIP-Seq_LIVER_Mouse7.00548638
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.22408386
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.84645836
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.41135597
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.55088316
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.30716712
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.63737995
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.43847819
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.69668771
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.59726101
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.34637337
13CLOCK_20551151_ChIP-Seq_293T_Human2.08050006
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.91750844
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.90198464
16LXR_22292898_ChIP-Seq_THP-1_Human1.87508208
17TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.85494808
18ZNF263_19887448_ChIP-Seq_K562_Human1.84895778
19VDR_24763502_ChIP-Seq_THP-1_Human1.77156825
20HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.62130861
21CTCF_27219007_Chip-Seq_ERYTHROID_Human1.61968597
22FOXA2_19822575_ChIP-Seq_HepG2_Human1.55990478
23MAF_26560356_Chip-Seq_TH1_Human1.55499774
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.52577852
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.43889277
26MAF_26560356_Chip-Seq_TH2_Human1.39721382
27* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.37626815
28GATA1_22025678_ChIP-Seq_K562_Human1.34807012
29RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.34162846
30SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33609637
31ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.33263757
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.32155045
33UTX_26944678_Chip-Seq_JUKART_Human1.31814985
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30797403
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.28025338
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.26831837
37NCOR1_26117541_ChIP-Seq_K562_Human1.25352204
38ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25078090
39RACK7_27058665_Chip-Seq_MCF-7_Human1.23370156
40TRIM28_21343339_ChIP-Seq_HEK293_Human1.22736631
41WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21733527
42* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21603582
43KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20779223
44* HNF4A_19822575_ChIP-Seq_HepG2_Human1.19954095
45PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19879153
46MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.19841872
47SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18196667
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17842825
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15844108
50RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15747249
51* SPI1_23127762_ChIP-Seq_K562_Human1.15270550
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15243723
53EGR1_19374776_ChIP-ChIP_THP-1_Human1.15056389
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14199989
55RUNX1_27514584_Chip-Seq_MCF-7_Human1.13648800
56GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12238142
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.12116540
58ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08738550
59MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.08144351
60DROSHA_22980978_ChIP-Seq_HELA_Human1.07922574
61MYC_22102868_ChIP-Seq_BL_Human1.04873432
62KDM2B_26808549_Chip-Seq_DND41_Human1.04128194
63PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03995357
64DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02394817
65KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02119018
66MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.01987674
67RXRA_24833708_ChIP-Seq_LIVER_Mouse1.01943405
68* TCF7_22412390_ChIP-Seq_EML_Mouse1.01442039
69TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00988371
70TP53_22127205_ChIP-Seq_IMR90_Human1.00632081
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00434469
72GATA1_19941826_ChIP-Seq_K562_Human0.99925867
73SA1_27219007_Chip-Seq_Bcells_Human0.99763567
74VDR_21846776_ChIP-Seq_THP-1_Human0.99488483
75P68_20966046_ChIP-Seq_HELA_Human0.99480972
76ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99025403
77NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98488558
78NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97926972
79BCOR_27268052_Chip-Seq_Bcells_Human0.96805463
80CREB1_26743006_Chip-Seq_LNCaP_Human0.96670900
81TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95225852
82JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.95131572
83ERG_21242973_ChIP-ChIP_JURKAT_Human0.94924137
84E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.90175057
85SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.89246166
86SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89072533
87SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88715883
88STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87999039
89* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.87959553
90ESR1_15608294_ChIP-ChIP_MCF-7_Human0.87798579
91GATA1_19941827_ChIP-Seq_MEL_Mouse0.87643015
92TET1_21451524_ChIP-Seq_MESCs_Mouse0.86588428
93SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.85625176
94STAT6_21828071_ChIP-Seq_BEAS2B_Human0.85026763
95CTCF_27219007_Chip-Seq_Bcells_Human0.84742626
96ELF1_20517297_ChIP-Seq_JURKAT_Human0.84043965
97BCL6_27268052_Chip-Seq_Bcells_Human0.83956236
98SA1_27219007_Chip-Seq_ERYTHROID_Human0.83534654
99SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82799781
100KDM2B_26808549_Chip-Seq_K562_Human0.81784983
101EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.80062943
102CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.80043373
103CTCF_21964334_ChIP-Seq_BJAB-B_Human0.78867903
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.78633408
105P300_27058665_Chip-Seq_ZR-75-30cells_Human0.78478687
106TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78121819
107TBX20_22328084_ChIP-Seq_HEART_Mouse0.76692621
108TBX20_22080862_ChIP-Seq_HEART_Mouse0.76692621
109RARA_24833708_ChIP-Seq_LIVER_Mouse0.76361707
110RARB_24833708_ChIP-Seq_LIVER_Mouse0.76127397
111PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.74466353
112SMC4_20622854_ChIP-Seq_HELA_Human0.74263981
113ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.74139432
114ATF3_27146783_Chip-Seq_COLON_Human0.73493189
115STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.72574896
116CTCF_21964334_Chip-Seq_Bcells_Human0.71856749
117KDM2B_26808549_Chip-Seq_JURKAT_Human0.71708584
118BRD4_27068464_Chip-Seq_AML-cells_Mouse0.70953362
119SCL_19346495_ChIP-Seq_HPC-7_Human0.69936534
120GATA4_25053715_ChIP-Seq_YYC3_Human0.69926695
121ZFP281_18757296_ChIP-ChIP_E14_Mouse0.69728890
122TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.69039874
123CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.68700557
124ESR1_21235772_ChIP-Seq_MCF-7_Human0.68633990
125GATA2_19941826_ChIP-Seq_K562_Human0.67939554
126TP63_22573176_ChIP-Seq_HFKS_Human0.67373053
127GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67004471
128FOXO3_23340844_ChIP-Seq_DLD1_Human0.66671983
129RAD21_21589869_ChIP-Seq_MESCs_Mouse0.66178914
130KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.66114739
131AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.65024122
132BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.65008613
133UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.64920543
134PHF8_20622854_ChIP-Seq_HELA_Human0.64274553

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.67329646
2MP0005360_urolithiasis7.00463813
3MP0005365_abnormal_bile_salt5.70903837
4MP0005085_abnormal_gallbladder_physiolo5.61252573
5MP0008875_abnormal_xenobiotic_pharmacok4.51517684
6MP0009840_abnormal_foam_cell3.83045807
7MP0003252_abnormal_bile_duct3.67632991
8MP0010329_abnormal_lipoprotein_level3.55769835
9MP0003806_abnormal_nucleotide_metabolis3.34793048
10MP0005083_abnormal_biliary_tract3.13854067
11MP0005332_abnormal_amino_acid2.80521368
12MP0003191_abnormal_cellular_cholesterol2.68745710
13MP0001666_abnormal_nutrient_absorption2.61146708
14MP0003195_calcinosis2.58709345
15MP0003172_abnormal_lysosome_physiology2.40605014
16MP0008438_abnormal_cutaneous_collagen2.32093828
17MP0005409_darkened_coat_color2.30876501
18MP0003436_decreased_susceptibility_to2.26415180
19MP0002118_abnormal_lipid_homeostasis2.22659424
20MP0000609_abnormal_liver_physiology2.20532882
21MP0003705_abnormal_hypodermis_morpholog2.09478203
22MP0001849_ear_inflammation2.08602408
23MP0008260_abnormal_autophagy2.01413915
24MP0003566_abnormal_cell_adhesion1.98144959
25MP0004019_abnormal_vitamin_homeostasis1.95385590
26MP0002138_abnormal_hepatobiliary_system1.86855338
27MP0005319_abnormal_enzyme/_coenzyme1.86559673
28MP0000751_myopathy1.83329487
29MP0005076_abnormal_cell_differentiation1.81278415
30MP0009278_abnormal_bone_marrow1.80343550
31MP0005584_abnormal_enzyme/coenzyme_acti1.71729765
32MP0003279_aneurysm1.66048912
33MP0000678_abnormal_parathyroid_gland1.61224878
34MP0005670_abnormal_white_adipose1.60549779
35MP0003868_abnormal_feces_composition1.60305589
36MP0004130_abnormal_muscle_cell1.59384691
37MP0002132_abnormal_respiratory_system1.56625316
38MP0002249_abnormal_larynx_morphology1.54840505
39MP0001958_emphysema1.49738869
40MP0009643_abnormal_urine_homeostasis1.48856495
41MP0003091_abnormal_cell_migration1.45820475
42MP0003453_abnormal_keratinocyte_physiol1.45534822
43MP0002089_abnormal_postnatal_growth/wei1.35297896
44MP0004947_skin_inflammation1.31824748
45MP0000604_amyloidosis1.28566119
46MP0000858_altered_metastatic_potential1.26011759
47MP0005666_abnormal_adipose_tissue1.22873965
48MP0010234_abnormal_vibrissa_follicle1.21444998
49MP0003879_abnormal_hair_cell1.19937914
50MP0003329_amyloid_beta_deposits1.19185875
51MP0000598_abnormal_liver_morphology1.17613504
52MP0003763_abnormal_thymus_physiology1.16836236
53MP0004510_myositis1.15224064
54MP0002396_abnormal_hematopoietic_system1.15151848
55MP0005023_abnormal_wound_healing1.14003075
56MP0001764_abnormal_homeostasis1.13557778
57MP0000681_abnormal_thyroid_gland1.12580626
58MP0003045_fibrosis1.11876693
59MP0003183_abnormal_peptide_metabolism1.11532247
60MP0000685_abnormal_immune_system1.10059844
61MP0002933_joint_inflammation1.09952727
62MP0006036_abnormal_mitochondrial_physio1.09193202
63MP0005451_abnormal_body_composition1.07571806
64MP0003656_abnormal_erythrocyte_physiolo1.06901242
65MP0010155_abnormal_intestine_physiology1.06106715
66MP0001348_abnormal_lacrimal_gland1.05966193
67MP0002419_abnormal_innate_immunity1.04836199
68MP0002877_abnormal_melanocyte_morpholog1.04758454
69MP0002971_abnormal_brown_adipose1.03548928
70MP0001873_stomach_inflammation1.02880661
71MP0002078_abnormal_glucose_homeostasis1.01935379
72MP0009384_cardiac_valve_regurgitation1.00241768
73MP0002837_dystrophic_cardiac_calcinosis0.99190811
74MP0005535_abnormal_body_temperature0.98656305
75MP0004381_abnormal_hair_follicle0.95500547
76MP0004264_abnormal_extraembryonic_tissu0.94758715
77MP0004859_abnormal_synaptic_plasticity0.94443309
78MP0002998_abnormal_bone_remodeling0.94422458
79MP0005636_abnormal_mineral_homeostasis0.94392418
80MP0002254_reproductive_system_inflammat0.93568076
81MP0005025_abnormal_response_to0.93556127
82MP0001533_abnormal_skeleton_physiology0.93477945
83MP0004185_abnormal_adipocyte_glucose0.90867184
84MP0000013_abnormal_adipose_tissue0.90215546
85MP0001756_abnormal_urination0.88366668
86MP0009642_abnormal_blood_homeostasis0.88072117
87MP0000759_abnormal_skeletal_muscle0.87762090
88MP0003011_delayed_dark_adaptation0.87606616
89MP0008961_abnormal_basal_metabolism0.87457434
90MP0005220_abnormal_exocrine_pancreas0.87183481
91MP0004272_abnormal_basement_membrane0.86789604
92MP0003300_gastrointestinal_ulcer0.86509242
93MP0005334_abnormal_fat_pad0.85361647
94MP0002896_abnormal_bone_mineralization0.82234287
95MP0009763_increased_sensitivity_to0.82054246
96MP0010368_abnormal_lymphatic_system0.81729994
97MP0003186_abnormal_redox_activity0.81720905
98MP0003828_pulmonary_edema0.81196872
99MP0003075_altered_response_to0.80163461
100MP0004087_abnormal_muscle_fiber0.79505094
101MP0005375_adipose_tissue_phenotype0.79282638
102MP0000462_abnormal_digestive_system0.78849913
103MP0009780_abnormal_chondrocyte_physiolo0.77443697
104MP0005167_abnormal_blood-brain_barrier0.77392791
105MP0005165_increased_susceptibility_to0.77267318
106MP0008469_abnormal_protein_level0.77245508
107MP0005647_abnormal_sex_gland0.77056837
108MP0003634_abnormal_glial_cell0.76658500
109MP0003866_abnormal_defecation0.76251516
110MP0003690_abnormal_glial_cell0.76010269
111MP0000767_abnormal_smooth_muscle0.74721772
112MP0005387_immune_system_phenotype0.73933234
113MP0001790_abnormal_immune_system0.73933234
114MP0010630_abnormal_cardiac_muscle0.73124371
115MP0004233_abnormal_muscle_weight0.71955219
116MP0005448_abnormal_energy_balance0.71708530
117MP0005501_abnormal_skin_physiology0.70040861
118MP0005397_hematopoietic_system_phenotyp0.69488969
119MP0009764_decreased_sensitivity_to0.67834500
120MP0002822_catalepsy0.67226689
121MP0004043_abnormal_pH_regulation0.66002256
122MP0005084_abnormal_gallbladder_morpholo0.65078382
123MP0006035_abnormal_mitochondrial_morpho0.64112018
124MP0002136_abnormal_kidney_physiology0.63821557
125MP0008874_decreased_physiological_sensi0.60767919
126MP0005058_abnormal_lysosome_morphology0.59240116
127MP0005376_homeostasis/metabolism_phenot0.57968489
128MP0002928_abnormal_bile_duct0.57429083
129MP0002909_abnormal_adrenal_gland0.56544538
130MP0002970_abnormal_white_adipose0.55499282
131MP0009765_abnormal_xenobiotic_induced0.54999461
132MP0003638_abnormal_response/metabolism_0.54861211
133MP0001765_abnormal_ion_homeostasis0.53402910
134MP0002269_muscular_atrophy0.52000370
135MP0002796_impaired_skin_barrier0.51874981
136MP0005166_decreased_susceptibility_to0.51636571
137MP0003953_abnormal_hormone_level0.51443730
138MP0001661_extended_life_span0.50583994
139MP0009672_abnormal_birth_weight0.50577449
140MP0005266_abnormal_metabolism0.50276899
141MP0005330_cardiomyopathy0.49649849
142MP0009115_abnormal_fat_cell0.48754792
143MP0001944_abnormal_pancreas_morphology0.48363043
144MP0005464_abnormal_platelet_physiology0.47772448
145MP0000639_abnormal_adrenal_gland0.47055323
146MP0000230_abnormal_systemic_arterial0.45023972
147MP0009697_abnormal_copulation0.44566562
148MP0000747_muscle_weakness0.44263110
149MP0003303_peritoneal_inflammation0.41725648
150MP0004858_abnormal_nervous_system0.41142660
151MP0008873_increased_physiological_sensi0.39953877
152MP0003959_abnormal_lean_body0.38709052
153MP0000249_abnormal_blood_vessel0.38512818
154MP0002168_other_aberrant_phenotype0.37510092
155MP0008872_abnormal_physiological_respon0.37460148
156MP0000003_abnormal_adipose_tissue0.37340733
157MP0002876_abnormal_thyroid_physiology0.35602514
158MP0002135_abnormal_kidney_morphology0.33531891
159MP0002060_abnormal_skin_morphology0.33504731
160MP0009053_abnormal_anal_canal0.33233838

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.60961301
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.49781137
3Intrahepatic cholestasis (HP:0001406)5.98607772
4Xanthomatosis (HP:0000991)5.83402072
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.55776978
6Hypobetalipoproteinemia (HP:0003563)5.18079265
7Hyperlipoproteinemia (HP:0010980)5.01691519
8Complement deficiency (HP:0004431)4.75615125
9Prolonged partial thromboplastin time (HP:0003645)4.70535534
10Ketosis (HP:0001946)4.61891310
11Hyperammonemia (HP:0001987)4.54634384
12Hyperglycinuria (HP:0003108)4.18886864
13Hypoglycemic coma (HP:0001325)4.11664302
14Abnormality of glycine metabolism (HP:0010895)4.02471494
15Abnormality of serine family amino acid metabolism (HP:0010894)4.02471494
16Hypolipoproteinemia (HP:0010981)4.02381615
17Epidermoid cyst (HP:0200040)4.01500925
18Hyperglycinemia (HP:0002154)4.00945037
19Abnormality of glutamine family amino acid metabolism (HP:0010902)3.88429578
20Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.72850553
21Hypoalphalipoproteinemia (HP:0003233)3.69962073
22Abnormality of the common coagulation pathway (HP:0010990)3.69952357
23Ketoacidosis (HP:0001993)3.69421413
24Joint hemorrhage (HP:0005261)3.68714463
25Abnormality of sulfur amino acid metabolism (HP:0004339)3.64961506
26Abnormality of fatty-acid metabolism (HP:0004359)3.52571011
27Abnormality of complement system (HP:0005339)3.48175769
28Abnormality of aspartate family amino acid metabolism (HP:0010899)3.43655099
29Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.43002120
30Hypercholesterolemia (HP:0003124)3.28679612
31Delayed CNS myelination (HP:0002188)3.25909408
32Protrusio acetabuli (HP:0003179)3.22815558
33Abnormality of methionine metabolism (HP:0010901)3.20127455
34Fat malabsorption (HP:0002630)3.17030508
35Obstructive sleep apnea (HP:0002870)3.14208218
36Cerebral aneurysm (HP:0004944)3.05748852
37Abnormality of the intrinsic pathway (HP:0010989)3.01707040
38Mucopolysacchariduria (HP:0008155)2.97523873
39Urinary glycosaminoglycan excretion (HP:0003541)2.97523873
40Gout (HP:0001997)2.96566694
41Hyperbilirubinemia (HP:0002904)2.93571020
42Distal upper limb amyotrophy (HP:0007149)2.82824342
43Upper limb amyotrophy (HP:0009129)2.82824342
44Abnormality of polysaccharide metabolism (HP:0011012)2.82328522
45Abnormality of glycosaminoglycan metabolism (HP:0004371)2.82328522
46Abnormality of mucopolysaccharide metabolism (HP:0011020)2.82328522
47Cervical subluxation (HP:0003308)2.80833416
48Increased connective tissue (HP:0009025)2.80616716
49Abnormality of dicarboxylic acid metabolism (HP:0010995)2.79445976
50Dicarboxylic aciduria (HP:0003215)2.79445976
51Abnormality of purine metabolism (HP:0004352)2.71147417
52Abnormality of nucleobase metabolism (HP:0010932)2.70695447
53Late onset (HP:0003584)2.70099470
54Broad face (HP:0000283)2.70054156
55Abnormality of pyrimidine metabolism (HP:0004353)2.69791508
56Premature rupture of membranes (HP:0001788)2.68062692
57Spastic diplegia (HP:0001264)2.66696377
58Hepatocellular carcinoma (HP:0001402)2.66119170
59Myocardial infarction (HP:0001658)2.62620963
60Metabolic acidosis (HP:0001942)2.61745902
61Skin nodule (HP:0200036)2.60893909
62Conjugated hyperbilirubinemia (HP:0002908)2.60434510
63Distal lower limb amyotrophy (HP:0008944)2.59423569
64Vertebral compression fractures (HP:0002953)2.57282726
65Neonatal onset (HP:0003623)2.56150912
66Increased variability in muscle fiber diameter (HP:0003557)2.56112620
67Abnormality of serum amino acid levels (HP:0003112)2.52222753
68Myopathic facies (HP:0002058)2.50334233
69Hyperacusis (HP:0010780)2.49412863
70Distal lower limb muscle weakness (HP:0009053)2.47464117
71Exercise-induced myalgia (HP:0003738)2.43174136
72Nasal polyposis (HP:0100582)2.42404858
73Abnormality of the nasal mucosa (HP:0000433)2.42267087
74Hypoglycemic seizures (HP:0002173)2.41420603
75Centrally nucleated skeletal muscle fibers (HP:0003687)2.39827755
76Amyloidosis (HP:0011034)2.39098759
77Systemic lupus erythematosus (HP:0002725)2.38153962
78Cholecystitis (HP:0001082)2.37696561
79Abnormal gallbladder physiology (HP:0012438)2.37696561
80Cellulitis (HP:0100658)2.35676766
81Lethargy (HP:0001254)2.34072316
82Malnutrition (HP:0004395)2.33980191
83Thin bony cortex (HP:0002753)2.33441064
84Cholelithiasis (HP:0001081)2.32024877
85Achilles tendon contracture (HP:0001771)2.31897113
86Eczematoid dermatitis (HP:0000976)2.31430966
87Myoglobinuria (HP:0002913)2.28210268
88Abnormal gallbladder morphology (HP:0012437)2.27948480
89Abnormality of skeletal muscle fiber size (HP:0012084)2.27840330
90Spontaneous abortion (HP:0005268)2.27788482
91Dysostosis multiplex (HP:0000943)2.27373117
92Ulnar bowing (HP:0003031)2.25864984
93Stridor (HP:0010307)2.25676826
94Hand muscle atrophy (HP:0009130)2.23044778
95Atelectasis (HP:0100750)2.21679498
96Sensorimotor neuropathy (HP:0007141)2.21162308
97Esophageal varix (HP:0002040)2.20441879
98Hyperinsulinemic hypoglycemia (HP:0000825)2.19145618
99Polygenic inheritance (HP:0010982)2.18806632
100Steatorrhea (HP:0002570)2.18694511
101Vascular calcification (HP:0004934)2.17957606
102Irritability (HP:0000737)2.16145690
103Generalized aminoaciduria (HP:0002909)2.15821619
104Abnormality of the Achilles tendon (HP:0005109)2.14680418
105Mitral stenosis (HP:0001718)2.14359356
106Colitis (HP:0002583)2.13993746
107Hemorrhage of the eye (HP:0011885)2.09066120
108Asymmetric septal hypertrophy (HP:0001670)2.06746090
109Joint stiffness (HP:0001387)2.05597413
110Mildly elevated creatine phosphokinase (HP:0008180)2.04948719
111Vomiting (HP:0002013)2.04391985
112Aneurysm (HP:0002617)2.02767558
113Cerebral edema (HP:0002181)2.01530309
114Fragile skin (HP:0001030)2.01281081
115Recurrent gram-negative bacterial infections (HP:0005420)2.00763446
116Acanthocytosis (HP:0001927)2.00046799
117Glomerulonephritis (HP:0000099)1.99797943
118Turricephaly (HP:0000262)1.99720438
119Difficulty climbing stairs (HP:0003551)1.99296110
120Abnormal cartilage morphology (HP:0002763)1.98819208
121Flat acetabular roof (HP:0003180)1.98638700
122Hydroxyprolinuria (HP:0003080)1.97062636
123Abnormality of proline metabolism (HP:0010907)1.97062636
124Dilatation of the ascending aorta (HP:0005111)1.96856819
125Pancreatitis (HP:0001733)1.95267477
126Polycythemia (HP:0001901)1.94029340
127Cardiovascular calcification (HP:0011915)1.93984415
128Short nail (HP:0001799)1.93755595
129Blue sclerae (HP:0000592)1.91307732
130Shallow orbits (HP:0000586)1.89716866
131Back pain (HP:0003418)1.89664739
132Increased purine levels (HP:0004368)1.87871345
133Hyperuricemia (HP:0002149)1.87871345
134Easy fatigability (HP:0003388)1.87635581
135Mitral regurgitation (HP:0001653)1.86987412
136Supranuclear gaze palsy (HP:0000605)1.86792334
137Abnormality of the gallbladder (HP:0005264)1.86203944
138Ulnar deviation of the wrist (HP:0003049)1.85844554
139Metaphyseal cupping (HP:0003021)1.83780078
140Global brain atrophy (HP:0002283)1.83020818
141Biconcave vertebral bodies (HP:0004586)1.82717765
142Emphysema (HP:0002097)1.82267568
143Ankle clonus (HP:0011448)1.81812160
144Hypertriglyceridemia (HP:0002155)1.81231344
145Thrombophlebitis (HP:0004418)1.80696120
146Gingivitis (HP:0000230)1.80507288
147Lymphangioma (HP:0100764)1.80197180
148Enlarged kidneys (HP:0000105)1.80179077
149Nephrolithiasis (HP:0000787)1.79979281
150Growth hormone excess (HP:0000845)1.79911273
151Bulbar palsy (HP:0001283)1.79180021
152Alkalosis (HP:0001948)1.79126230
153Gingival bleeding (HP:0000225)1.78791881
154Cerebral inclusion bodies (HP:0100314)1.78684447
155Status epilepticus (HP:0002133)1.77574825
156Neurofibrillary tangles (HP:0002185)1.77558280
157Interstitial pulmonary disease (HP:0006530)1.76938098
158Death in childhood (HP:0003819)1.76503746
159Spinal rigidity (HP:0003306)1.76090750
160Reticulocytosis (HP:0001923)1.76078805
161Abnormal enzyme/coenzyme activity (HP:0012379)1.75260004
162Stroke (HP:0001297)1.74004139
163Abnormality of transition element cation homeostasis (HP:0011030)1.73925056
164Type 1 muscle fiber predominance (HP:0003803)1.73164633
165Disproportionate tall stature (HP:0001519)1.72825282
166Gastrointestinal inflammation (HP:0004386)1.72474992
167Lower limb amyotrophy (HP:0007210)1.70839105
168Gastrointestinal stroma tumor (HP:0100723)1.70734396
169Purpura (HP:0000979)1.69908200
170Arterial tortuosity (HP:0005116)1.67697338
171Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.65871600
172Increased IgE level (HP:0003212)1.65776432
173Hyporeflexia of lower limbs (HP:0002600)1.65446756
174Bronchomalacia (HP:0002780)1.64356945
175J-shaped sella turcica (HP:0002680)1.64049522
176Atrophic scars (HP:0001075)1.63594443
177Vascular tortuosity (HP:0004948)1.59186243
178Acanthosis nigricans (HP:0000956)1.58521547
179Abnormality of macrophages (HP:0004311)1.57667439
180Abnormality of the acetabulum (HP:0003170)1.56347923
181Gastrointestinal dysmotility (HP:0002579)1.56108361
182Osteolytic defects of the hand bones (HP:0009699)1.55622292

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.01152226
2TRIB34.93384325
3ERN14.78022087
4PKN23.78265020
5PRPF4B3.47753977
6SIK13.42455141
7FGFR43.28388553
8SMG13.22409069
9MAP3K102.64305196
10INSRR2.23623313
11PTK62.10104123
12RIPK12.04282002
13EEF2K1.92500716
14RIPK41.84689285
15EPHA21.83909682
16MAP3K71.52476246
17CAMK1D1.45117340
18FLT31.42980621
19DAPK21.42057862
20ICK1.41311950
21TNK21.40072372
22TAOK31.33854598
23GRK61.32754290
24CAMK1G1.24787853
25MAPK111.23066537
26MAP2K41.23036770
27TAOK21.18217047
28LRRK21.14464281
29TYK21.14125084
30MAP3K31.13991035
31IRAK31.12576941
32FGFR21.12380960
33TESK11.11622313
34MAP3K61.11316378
35KSR21.08764695
36MAP4K11.04641967
37EPHB11.02015798
38CDK121.01725008
39JAK20.99240484
40MST1R0.99080261
41CDC42BPA0.97409472
42DYRK1B0.95700646
43PDGFRA0.95162869
44MAP2K30.93497341
45TTN0.92776588
46RET0.92605275
47MAP3K90.86094123
48PINK10.85032454
49PRKAA20.84973141
50PRKD30.84145105
51TGFBR20.82825498
52TBK10.82397265
53PTK20.81857257
54PDK40.80292037
55PDK30.80292037
56MAP3K130.80206712
57JAK10.77752399
58CAMKK10.77459417
59BLK0.76137473
60PDPK10.76104013
61MTOR0.76028026
62HIPK20.75555351
63TESK20.74045792
64MET0.73599267
65MAP2K20.71839368
66MAP3K10.71102521
67KDR0.71033586
68ERBB40.69843720
69RPS6KC10.67124674
70RPS6KL10.67124674
71IRAK40.66924797
72SIK20.65874294
73MAPK120.65854707
74FES0.65737902
75WNK40.64197744
76LMTK20.63457152
77PDK10.63161071
78PRKCH0.63106413
79BMX0.62922496
80PRKG20.62839810
81NME20.61641132
82TYRO30.61321754
83MAP3K110.61196620
84PRKD10.61059874
85PIK3CG0.60146349
86PAK40.60028834
87CDK60.59867442
88HCK0.59675827
89ERBB20.59589308
90MAP3K20.59477191
91PRKAA10.59246139
92JAK30.58000762
93TIE10.57855504
94MAPK150.56874298
95CSF1R0.55332474
96MAPK40.55246129
97MAPK70.55159410
98PRKCZ0.54190181
99PHKG10.52477212
100PHKG20.52477212
101ABL20.52200336
102TAOK10.50616879
103CAMK40.50607816
104ZAP700.50283736
105GSK3A0.47885361
106MAP3K80.46727786
107FGFR30.46559842
108PRKACG0.45324661
109RPS6KA60.43487935
110LATS10.42771945
111MAP3K140.42709858
112MAPKAPK30.42130449
113MAP2K60.41805239
114CSK0.41084263
115CDK40.40969645
116BTK0.40819029
117DDR20.40645520
118SGK30.40164054
119PDGFRB0.39828079
120NTRK30.39683164
121MARK20.39582832
122PAK20.38951650
123IRAK20.38394025
124MAP2K10.38049596
125SIK30.38001547
126STK380.37468961
127ARAF0.36066734
128NTRK10.32545359
129PAK30.32362941
130DAPK30.32327465
131PRKD20.32076843
132STK110.31585493
133FYN0.30639140
134RPS6KA20.29809351

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.08464143
2Nitrogen metabolism_Homo sapiens_hsa009103.88885699
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.39512015
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.15613887
5Other glycan degradation_Homo sapiens_hsa005113.02937993
6Arginine biosynthesis_Homo sapiens_hsa002203.02072287
7Fatty acid degradation_Homo sapiens_hsa000712.81054535
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.73781420
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.63643314
10Tryptophan metabolism_Homo sapiens_hsa003802.59704131
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.52172864
12Complement and coagulation cascades_Homo sapiens_hsa046102.32135485
13Propanoate metabolism_Homo sapiens_hsa006402.28610240
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.25885413
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.21596117
16Butanoate metabolism_Homo sapiens_hsa006502.18724870
17PPAR signaling pathway_Homo sapiens_hsa033202.12792442
18Fatty acid metabolism_Homo sapiens_hsa012122.08395882
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.97887041
20* Peroxisome_Homo sapiens_hsa041461.93941928
21beta-Alanine metabolism_Homo sapiens_hsa004101.75078810
22Bile secretion_Homo sapiens_hsa049761.67869684
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.67180637
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.66988546
25Pyruvate metabolism_Homo sapiens_hsa006201.65444194
26Histidine metabolism_Homo sapiens_hsa003401.59736924
27Caffeine metabolism_Homo sapiens_hsa002321.58918407
28Chronic myeloid leukemia_Homo sapiens_hsa052201.55087429
29Selenocompound metabolism_Homo sapiens_hsa004501.53270498
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.53034131
31Chemical carcinogenesis_Homo sapiens_hsa052041.51158562
32VEGF signaling pathway_Homo sapiens_hsa043701.50672372
33Notch signaling pathway_Homo sapiens_hsa043301.46205594
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.45483787
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.44840605
36Carbon metabolism_Homo sapiens_hsa012001.43415668
37Staphylococcus aureus infection_Homo sapiens_hsa051501.41148280
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.40266404
39B cell receptor signaling pathway_Homo sapiens_hsa046621.39559305
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.38689462
41Biosynthesis of amino acids_Homo sapiens_hsa012301.38031173
42Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.37639214
43Phenylalanine metabolism_Homo sapiens_hsa003601.36079123
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.35291878
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29104707
46Fat digestion and absorption_Homo sapiens_hsa049751.28465323
47Retinol metabolism_Homo sapiens_hsa008301.24386757
48Starch and sucrose metabolism_Homo sapiens_hsa005001.23009210
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.22613653
50ABC transporters_Homo sapiens_hsa020101.21744957
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21669029
52Cyanoamino acid metabolism_Homo sapiens_hsa004601.20985071
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19564287
54Sulfur metabolism_Homo sapiens_hsa009201.18158372
55Tyrosine metabolism_Homo sapiens_hsa003501.16286781
56GnRH signaling pathway_Homo sapiens_hsa049121.14327402
57Fatty acid elongation_Homo sapiens_hsa000621.14209957
58Sulfur relay system_Homo sapiens_hsa041221.09733783
59Inositol phosphate metabolism_Homo sapiens_hsa005621.05354397
60Pancreatic cancer_Homo sapiens_hsa052121.02842618
61Lysine degradation_Homo sapiens_hsa003101.02272638
62Endometrial cancer_Homo sapiens_hsa052131.02258776
63Maturity onset diabetes of the young_Homo sapiens_hsa049501.01962072
64Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01729910
65Neurotrophin signaling pathway_Homo sapiens_hsa047221.00848222
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.00658443
67Folate biosynthesis_Homo sapiens_hsa007900.99747215
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.99590602
69Osteoclast differentiation_Homo sapiens_hsa043800.97761146
70Glycerolipid metabolism_Homo sapiens_hsa005610.96930113
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96450517
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.96141274
73Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94338369
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.93880577
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92262915
76mTOR signaling pathway_Homo sapiens_hsa041500.88899220
77Arginine and proline metabolism_Homo sapiens_hsa003300.87390363
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85843117
79Choline metabolism in cancer_Homo sapiens_hsa052310.85582469
80ErbB signaling pathway_Homo sapiens_hsa040120.85056888
81Focal adhesion_Homo sapiens_hsa045100.84141106
82Leishmaniasis_Homo sapiens_hsa051400.83620086
83Hepatitis C_Homo sapiens_hsa051600.82539119
84Fatty acid biosynthesis_Homo sapiens_hsa000610.81458775
85Glioma_Homo sapiens_hsa052140.80431636
86Estrogen signaling pathway_Homo sapiens_hsa049150.79126010
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77368029
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76655264
89Renal cell carcinoma_Homo sapiens_hsa052110.75005568
90Endocytosis_Homo sapiens_hsa041440.74046638
91Long-term potentiation_Homo sapiens_hsa047200.72531274
92Prolactin signaling pathway_Homo sapiens_hsa049170.71937541
93Pentose phosphate pathway_Homo sapiens_hsa000300.71708393
94Toxoplasmosis_Homo sapiens_hsa051450.71252757
95Vitamin digestion and absorption_Homo sapiens_hsa049770.68408722
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.67753636
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64276046
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.62382512
99Insulin resistance_Homo sapiens_hsa049310.61296244
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59097605
101Toll-like receptor signaling pathway_Homo sapiens_hsa046200.59042968
102Thyroid cancer_Homo sapiens_hsa052160.57609523
103Platelet activation_Homo sapiens_hsa046110.56823333
104Influenza A_Homo sapiens_hsa051640.54398835
105Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.52847569
106ECM-receptor interaction_Homo sapiens_hsa045120.51139172
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49900952
108Proteoglycans in cancer_Homo sapiens_hsa052050.49728231
109Tuberculosis_Homo sapiens_hsa051520.49515697
110Sphingolipid metabolism_Homo sapiens_hsa006000.49250219
111Steroid biosynthesis_Homo sapiens_hsa001000.48845400
112Hepatitis B_Homo sapiens_hsa051610.48290834
113Small cell lung cancer_Homo sapiens_hsa052220.46347314
114Vitamin B6 metabolism_Homo sapiens_hsa007500.45645807
115Glutathione metabolism_Homo sapiens_hsa004800.45225146
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43897660
117Glucagon signaling pathway_Homo sapiens_hsa049220.43049164
118Prion diseases_Homo sapiens_hsa050200.40623218
119One carbon pool by folate_Homo sapiens_hsa006700.36313167
120Galactose metabolism_Homo sapiens_hsa000520.35868638
121AMPK signaling pathway_Homo sapiens_hsa041520.34006134
122Metabolic pathways_Homo sapiens_hsa011000.33655190
123Fructose and mannose metabolism_Homo sapiens_hsa000510.33182011
124Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31399961
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.23971159
126Insulin signaling pathway_Homo sapiens_hsa049100.23877223
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.19324872
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.15326796
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.08216283
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.06083079
131alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.06055572
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.04513701
133Thyroid hormone synthesis_Homo sapiens_hsa049180.02969656
134Type II diabetes mellitus_Homo sapiens_hsa049300.02469092
135Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.00874914
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.00583710
137Acute myeloid leukemia_Homo sapiens_hsa05221-0.1430044
138Lysosome_Homo sapiens_hsa04142-0.1390313
139Non-small cell lung cancer_Homo sapiens_hsa05223-0.0958696
140Amoebiasis_Homo sapiens_hsa05146-0.0911365
141Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.0836888
142Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0792155
143Bladder cancer_Homo sapiens_hsa05219-0.0775671
144Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.0607968
145Protein digestion and absorption_Homo sapiens_hsa04974-0.0606653
146Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0538272
147Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0399417
148Linoleic acid metabolism_Homo sapiens_hsa00591-0.0386054
149Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0294872

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