PF4V1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a chemokine that is highly similar to platelet factor 4. The encoded protein displays a strong antiangiogenic function and is regulated by chemokine (C-X-C motif) receptor 3. This protein also impairs tumor growth and can protect against blood-retinal barrier breakdown in diabetes patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)7.90479980
2protein neddylation (GO:0045116)7.79455767
3neutrophil activation involved in immune response (GO:0002283)7.53670639
4regulation of platelet aggregation (GO:0090330)6.26787144
5blood coagulation, intrinsic pathway (GO:0007597)6.15747425
6regulation of platelet activation (GO:0010543)5.85980690
7adenosine receptor signaling pathway (GO:0001973)5.57108650
8platelet aggregation (GO:0070527)5.54676607
9negative regulation of homotypic cell-cell adhesion (GO:0034111)5.31760348
10leukocyte migration involved in inflammatory response (GO:0002523)5.25881151
11negative regulation of thymocyte apoptotic process (GO:0070244)5.20057077
12positive regulation of endothelial cell differentiation (GO:0045603)5.18979920
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.17644122
14regulation of integrin-mediated signaling pathway (GO:2001044)5.14184139
15negative regulation of norepinephrine secretion (GO:0010700)5.08522805
16negative regulation of platelet activation (GO:0010544)4.95864567
17lipoxygenase pathway (GO:0019372)4.72772845
18positive regulation of mast cell activation (GO:0033005)4.71839975
19G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.59431206
20angiogenesis involved in wound healing (GO:0060055)4.58499117
21negative regulation of heart rate (GO:0010459)4.56679699
22neutrophil activation (GO:0042119)4.51423513
23negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.49365856
24platelet degranulation (GO:0002576)4.28205721
25regulation of lipoprotein metabolic process (GO:0050746)4.19797164
26purinergic nucleotide receptor signaling pathway (GO:0035590)4.14294871
27regulation of integrin activation (GO:0033623)4.12480975
28positive regulation of cAMP-mediated signaling (GO:0043950)4.11860883
29polyamine biosynthetic process (GO:0006596)4.10729698
30low-density lipoprotein particle remodeling (GO:0034374)4.07391463
31positive regulation of macrophage differentiation (GO:0045651)4.02117794
32granulocyte activation (GO:0036230)3.96613529
33megakaryocyte development (GO:0035855)3.93218711
34negative regulation of protein localization to cell surface (GO:2000009)3.92903498
35homotypic cell-cell adhesion (GO:0034109)3.88819231
36platelet activation (GO:0030168)3.88417807
37regulation of homotypic cell-cell adhesion (GO:0034110)3.82585010
38negative regulation of appetite (GO:0032099)3.81534226
39negative regulation of response to food (GO:0032096)3.81534226
40regulation of Golgi to plasma membrane protein transport (GO:0042996)3.79142352
41positive regulation of Rho protein signal transduction (GO:0035025)3.72442780
42negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.72374298
43fusion of sperm to egg plasma membrane (GO:0007342)3.70546128
44platelet formation (GO:0030220)3.66772223
45regulation of MHC class II biosynthetic process (GO:0045346)3.64695877
46positive regulation of hemostasis (GO:1900048)3.59897039
47positive regulation of blood coagulation (GO:0030194)3.59897039
48purinergic receptor signaling pathway (GO:0035587)3.55491900
49positive regulation of receptor recycling (GO:0001921)3.55384802
50G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.54300624
51positive regulation of systemic arterial blood pressure (GO:0003084)3.52690571
52regulation of endothelial cell differentiation (GO:0045601)3.50582447
53regulation of macrophage derived foam cell differentiation (GO:0010743)3.50418363
54regulation of norepinephrine secretion (GO:0014061)3.48499803
55negative regulation of heart contraction (GO:0045822)3.45820441
56autophagic vacuole fusion (GO:0000046)3.43027768
57positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.41826898
58beta-amyloid metabolic process (GO:0050435)3.39011427
59negative regulation of T cell apoptotic process (GO:0070233)3.36285704
60termination of G-protein coupled receptor signaling pathway (GO:0038032)3.33678644
61negative regulation of neural precursor cell proliferation (GO:2000178)3.30655982
62termination of signal transduction (GO:0023021)3.29002038
63extracellular fibril organization (GO:0043206)3.24884193
64phagocytosis, engulfment (GO:0006911)3.22889784
65positive regulation of coagulation (GO:0050820)3.21154606
66long-chain fatty acid biosynthetic process (GO:0042759)3.19415063
67fatty acid elongation (GO:0030497)3.18001019
68mitochondrial calcium ion transport (GO:0006851)3.15879432
69negative regulation of catecholamine secretion (GO:0033604)3.14023254
70leukocyte degranulation (GO:0043299)3.10393918
71vesicle targeting (GO:0006903)3.09000165
72negative regulation of T-helper cell differentiation (GO:0045623)3.07101039
73negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.07101039
74negative regulation of calcium ion transport into cytosol (GO:0010523)3.05735394
75regulation of mast cell activation (GO:0033003)3.05693958
76pyrimidine nucleoside catabolic process (GO:0046135)3.04782400
77negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.01723960
78regulation of female receptivity (GO:0045924)2.97693661
79regulation of blood coagulation (GO:0030193)2.97650685
80regulation of hemostasis (GO:1900046)2.97650685
81cyclooxygenase pathway (GO:0019371)2.96237103
82high-density lipoprotein particle remodeling (GO:0034375)2.94590370
83cellular biogenic amine biosynthetic process (GO:0042401)2.91778859
84negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.88257200
85positive regulation of mast cell activation involved in immune response (GO:0033008)2.86157947
86positive regulation of mast cell degranulation (GO:0043306)2.86157947
87regulation of regulatory T cell differentiation (GO:0045589)2.85522232
88regulation of receptor recycling (GO:0001919)2.85100915
89membrane invagination (GO:0010324)2.83938957
90regulation of mast cell degranulation (GO:0043304)2.83878150
91regulation of memory T cell differentiation (GO:0043380)2.83333800
92regulation of cholesterol efflux (GO:0010874)2.81662846
93reverse cholesterol transport (GO:0043691)2.81405613
94negative regulation of stress fiber assembly (GO:0051497)2.79740806
95fibril organization (GO:0097435)2.75677715
96negative regulation of focal adhesion assembly (GO:0051895)2.75550413
97negative regulation of cell junction assembly (GO:1901889)2.75550413
98negative regulation of adherens junction organization (GO:1903392)2.75550413
99negative regulation of protein localization to plasma membrane (GO:1903077)2.75331862
100positive regulation of B cell mediated immunity (GO:0002714)2.74251324

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.93457424
2LYL1_20887958_ChIP-Seq_HPC-7_Mouse4.29468836
3SCL_19346495_ChIP-Seq_HPC-7_Human4.20355386
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.33740947
5RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.29636738
6GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.18035436
7GATA1_19941826_ChIP-Seq_K562_Human3.05193579
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.04937460
9LMO2_20887958_ChIP-Seq_HPC-7_Mouse2.83484681
10GATA2_19941826_ChIP-Seq_K562_Human2.63211216
11GATA1_19941827_ChIP-Seq_MEL_Mouse2.61206762
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.60197660
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.53032509
14SPI1_23127762_ChIP-Seq_K562_Human2.35943926
15GATA2_21666600_ChIP-Seq_HMVEC_Human2.32614754
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.32297942
17EZH2_22144423_ChIP-Seq_EOC_Human2.31024686
18TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.21866087
19SRY_22984422_ChIP-ChIP_TESTIS_Rat2.21173063
20GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.18424684
21GATA1_22383799_ChIP-Seq_G1ME_Mouse2.15330409
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.09604936
23ELK4_26923725_Chip-Seq_MESODERM_Mouse2.07189555
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.97343065
25GBX2_23144817_ChIP-Seq_PC3_Human1.95637003
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93316861
27RUNX1_22412390_ChIP-Seq_EML_Mouse1.88905234
28MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.87973424
29HTT_18923047_ChIP-ChIP_STHdh_Human1.87269539
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.86352686
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.84565302
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83199162
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.80850452
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.71093206
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.68596028
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66604053
37SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66309340
38GATA1_19941827_ChIP-Seq_MEL86_Mouse1.63454741
39GATA1_22025678_ChIP-Seq_K562_Human1.60585219
40PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50362503
41RUNX_20019798_ChIP-Seq_JUKART_Human1.42784181
42TAF15_26573619_Chip-Seq_HEK293_Human1.40238863
43GATA2_22383799_ChIP-Seq_G1ME_Mouse1.31176504
44PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30780370
45NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.29195408
46NRF2_20460467_ChIP-Seq_MEFs_Mouse1.29195408
47PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.28487106
48FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25378240
49KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.20096027
50STAT4_19710469_ChIP-ChIP_TH1__Mouse1.09755569
51SPI1_20517297_ChIP-Seq_HL60_Human1.07545482
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05842645
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04657440
54NCOR1_26117541_ChIP-Seq_K562_Human1.04235765
55ESR1_20079471_ChIP-ChIP_T-47D_Human1.03635000
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03356156
57ETS1_22383799_ChIP-Seq_G1ME_Mouse1.02102191
58STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.01307560
59* SALL4_22934838_ChIP-ChIP_CD34+_Human0.97636872
60LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96478852
61NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95226639
62E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93903692
63SPI1_23547873_ChIP-Seq_NB4_Human0.93350803
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.89381098
65UTX_26944678_Chip-Seq_JUKART_Human0.88917488
66STAT1_20625510_ChIP-Seq_HELA_Human0.87079734
67STAT6_21828071_ChIP-Seq_BEAS2B_Human0.87043488
68TCF4_18268006_ChIP-ChIP_LS174T_Human0.86746870
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86066843
70FOXO3_23340844_ChIP-Seq_DLD1_Human0.86057936
71GATA3_27048872_Chip-Seq_THYMUS_Human0.84944910
72JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84719805
73CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83889583
74SOX2_20726797_ChIP-Seq_SW620_Human0.83547736
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.83340513
76OCT1_27270436_Chip-Seq_PROSTATE_Human0.83298074
77HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82134025
78GATA3_21878914_ChIP-Seq_MCF-7_Human0.82103051
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.81723137
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.80937810
81GATA3_26560356_Chip-Seq_TH2_Human0.79763728
82CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78999028
83MYB_26560356_Chip-Seq_TH2_Human0.78707886
84EGR1_23403033_ChIP-Seq_LIVER_Mouse0.78677288
85FLI1_27457419_Chip-Seq_LIVER_Mouse0.76941443
86JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76619780
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.76298997
88EZH2_27294783_Chip-Seq_NPCs_Mouse0.76031201
89RARG_19884340_ChIP-ChIP_MEFs_Mouse0.75956508
90GATA4_25053715_ChIP-Seq_YYC3_Human0.75046714
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.74476357
92PU_27001747_Chip-Seq_BMDM_Mouse0.74413267
93SMRT_27268052_Chip-Seq_Bcells_Human0.73989287
94PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.73790564
95SMAD4_21799915_ChIP-Seq_A2780_Human0.72381989
96TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.72083255
97GF1_26923725_Chip-Seq_HPCs_Mouse0.71942785
98CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.71416186
99PPAR_26484153_Chip-Seq_NCI-H1993_Human0.71278929
100BCAT_22108803_ChIP-Seq_LS180_Human0.70297576

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH5.60000585
2MP0003724_increased_susceptibility_to4.00234400
3MP0000465_gastrointestinal_hemorrhage3.60511203
4MP0004510_myositis3.15747595
5MP0005083_abnormal_biliary_tract2.50323647
6MP0003303_peritoneal_inflammation2.46143655
7MP0000343_altered_response_to2.35721580
8MP0003566_abnormal_cell_adhesion2.31721437
9MP0001835_abnormal_antigen_presentation2.30092472
10MP0004084_abnormal_cardiac_muscle2.18143437
11MP0002736_abnormal_nociception_after2.13997541
12MP0000230_abnormal_systemic_arterial2.08571945
13MP0005464_abnormal_platelet_physiology10.0950480
14MP0005671_abnormal_response_to1.84374692
15MP0003638_abnormal_response/metabolism_1.76732959
16MP0003828_pulmonary_edema1.76579546
17MP0010155_abnormal_intestine_physiology1.71333064
18MP0008775_abnormal_heart_ventricle1.68300509
19MP0002148_abnormal_hypersensitivity_rea1.68202229
20MP0005084_abnormal_gallbladder_morpholo1.67532594
21MP0001851_eye_inflammation1.65229588
22MP0005167_abnormal_blood-brain_barrier1.65076166
23MP0005058_abnormal_lysosome_morphology1.61186698
24MP0005000_abnormal_immune_tolerance1.58093088
25MP0008872_abnormal_physiological_respon1.57610254
26MP0001879_abnormal_lymphatic_vessel1.57343724
27MP0003879_abnormal_hair_cell1.55608340
28MP0004036_abnormal_muscle_relaxation1.54312142
29MP0005410_abnormal_fertilization1.53135682
30MP0004130_abnormal_muscle_cell1.46229221
31MP0003436_decreased_susceptibility_to1.46027884
32MP0002398_abnormal_bone_marrow1.44611906
33MP0001663_abnormal_digestive_system1.39977988
34MP0000249_abnormal_blood_vessel1.37688162
35MP0002132_abnormal_respiratory_system1.34594029
36MP0001545_abnormal_hematopoietic_system1.34255165
37MP0005397_hematopoietic_system_phenotyp1.34255165
38MP0004947_skin_inflammation1.32493594
39MP0001968_abnormal_touch/_nociception1.32108273
40MP0001533_abnormal_skeleton_physiology1.25818890
41MP0009763_increased_sensitivity_to1.24503776
42MP0002723_abnormal_immune_serum1.22085922
43MP0005646_abnormal_pituitary_gland1.21891975
44MP0010329_abnormal_lipoprotein_level1.21366149
45MP0000858_altered_metastatic_potential1.19888885
46MP0002733_abnormal_thermal_nociception1.17057495
47MP0009764_decreased_sensitivity_to1.16535088
48MP0003300_gastrointestinal_ulcer1.14049148
49MP0003866_abnormal_defecation1.13496891
50MP0001800_abnormal_humoral_immune1.12175802
51MP0002452_abnormal_antigen_presenting1.10520207
52MP0008874_decreased_physiological_sensi1.04001716
53MP0002429_abnormal_blood_cell1.02645539
54MP0000689_abnormal_spleen_morphology1.01986000
55MP0002419_abnormal_innate_immunity0.98615939
56MP0002420_abnormal_adaptive_immunity0.98043087
57MP0006054_spinal_hemorrhage0.97273811
58MP0003656_abnormal_erythrocyte_physiolo0.97203284
59MP0001819_abnormal_immune_cell0.96538870
60MP0009642_abnormal_blood_homeostasis0.95656489
61MP0001790_abnormal_immune_system0.95533577
62MP0005387_immune_system_phenotype0.95533577
63MP0009765_abnormal_xenobiotic_induced0.95084986
64MP0001845_abnormal_inflammatory_respons0.92806475
65MP0002998_abnormal_bone_remodeling0.91757049
66MP0002722_abnormal_immune_system0.90959110
67MP0004215_abnormal_myocardial_fiber0.88747088
68MP0005381_digestive/alimentary_phenotyp0.87689762
69MP0005023_abnormal_wound_healing0.87595651
70MP0005025_abnormal_response_to0.87312580
71MP0000716_abnormal_immune_system0.86892106
72MP0005165_increased_susceptibility_to0.85736391
73MP0009333_abnormal_splenocyte_physiolog0.85069992
74MP0001664_abnormal_digestion0.83400673
75MP0001970_abnormal_pain_threshold0.83319513
76MP0000685_abnormal_immune_system0.82080406
77MP0001765_abnormal_ion_homeostasis0.81770595
78MP0009697_abnormal_copulation0.80021727
79MP0005666_abnormal_adipose_tissue0.79970419
80MP0006276_abnormal_autonomic_nervous0.79445477
81MP0000015_abnormal_ear_pigmentation0.79368550
82MP0002972_abnormal_cardiac_muscle0.78066747
83MP0004484_altered_response_of0.76964031
84MP0001544_abnormal_cardiovascular_syste0.75557986
85MP0005385_cardiovascular_system_phenoty0.75557986
86MP0004883_abnormal_blood_vessel0.75265840
87MP0003075_altered_response_to0.74635183
88MP0005409_darkened_coat_color0.71244274
89MP0005535_abnormal_body_temperature0.70951689
90MP0003453_abnormal_keratinocyte_physiol0.70938425
91MP0008260_abnormal_autophagy0.70177234
92MP0002118_abnormal_lipid_homeostasis0.69932943
93MP0002128_abnormal_blood_circulation0.69166303
94MP0005501_abnormal_skin_physiology0.67780677
95MP0000490_abnormal_crypts_of0.66587803
96MP0006138_congestive_heart_failure0.64081221
97MP0005620_abnormal_muscle_contractility0.60920911
98MP0003183_abnormal_peptide_metabolism0.60188003
99MP0005365_abnormal_bile_salt0.59679528
100MP0001756_abnormal_urination0.58804839

Predicted human phenotypes

RankGene SetZ-score
1Purpura (HP:0000979)9.58048775
2Epistaxis (HP:0000421)7.97647723
3Gingival bleeding (HP:0000225)6.89418707
4Hyperlipoproteinemia (HP:0010980)5.91263753
5Impaired platelet aggregation (HP:0003540)5.85863898
6Abnormal platelet function (HP:0011869)5.85863898
7Spontaneous hematomas (HP:0007420)4.37808357
8Poikilocytosis (HP:0004447)4.21481538
9Acanthocytosis (HP:0001927)4.20841385
10Dyschromatopsia (HP:0007641)4.03184585
11Conjunctival telangiectasia (HP:0000524)3.61577386
12Abnormality of the common coagulation pathway (HP:0010990)3.50418588
13Bruising susceptibility (HP:0000978)3.48572903
14Abnormal pupillary function (HP:0007686)3.39631040
15Increased density of long bones (HP:0006392)3.18877464
16Abnormality of the vasculature of the conjunctiva (HP:0008054)3.16125782
17Abnormality of lateral ventricle (HP:0030047)3.03840664
18Paralysis (HP:0003470)2.94848589
19Abnormality of the heme biosynthetic pathway (HP:0010472)2.86545952
20Xanthomatosis (HP:0000991)2.60645313
21Hepatosplenomegaly (HP:0001433)2.52120949
22Abnormality of macrophages (HP:0004311)2.49958538
23Abnormal auditory evoked potentials (HP:0006958)2.45733673
24Joint swelling (HP:0001386)2.43922785
25Upper limb muscle weakness (HP:0003484)2.42864714
26Increased IgM level (HP:0003496)2.40460099
27Joint hemorrhage (HP:0005261)2.35725479
28Stomatitis (HP:0010280)2.33718047
29Decreased central vision (HP:0007663)2.22426132
30Abnormality of iron homeostasis (HP:0011031)2.15455618
31Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.14803142
32Hyperthyroidism (HP:0000836)2.11688955
33Tinnitus (HP:0000360)2.11172125
34Ventricular fibrillation (HP:0001663)2.03381328
35Chronic obstructive pulmonary disease (HP:0006510)2.00824930
36Obstructive lung disease (HP:0006536)2.00824930
37Prolonged bleeding time (HP:0003010)12.1756633
38Menorrhagia (HP:0000132)11.3333446
39Increased mean platelet volume (HP:0011877)11.3152470
40Abnormal platelet volume (HP:0011876)10.6686649
41Petechiae (HP:0000967)10.0770722
42Generalized aminoaciduria (HP:0002909)1.99167525
43Nausea (HP:0002018)1.99051728
44Encephalitis (HP:0002383)1.97229577
45Male infertility (HP:0003251)1.96262917
46Spontaneous abortion (HP:0005268)1.94071982
473-Methylglutaconic aciduria (HP:0003535)1.91087206
48Abnormality of transition element cation homeostasis (HP:0011030)1.88962327
49Arterial thrombosis (HP:0004420)1.83876362
50Papillary thyroid carcinoma (HP:0002895)1.83121660
51Thyroid-stimulating hormone excess (HP:0002925)1.80845886
52Myocardial infarction (HP:0001658)1.80701111
53Episodic fever (HP:0001954)1.78418126
54Increased serum ferritin (HP:0003281)1.77528052
55Dysautonomia (HP:0002459)1.74015992
56Polycythemia (HP:0001901)1.72303173
57Tongue fasciculations (HP:0001308)1.71580309
58Autoimmune hemolytic anemia (HP:0001890)1.68072225
59Distal lower limb amyotrophy (HP:0008944)1.67889502
60Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.66019273
61Muscle fibrillation (HP:0010546)1.63958926
62Hypophosphatemic rickets (HP:0004912)1.61506031
63Eczematoid dermatitis (HP:0000976)1.61354202
64Biliary tract neoplasm (HP:0100574)1.60015484
65Leiomyosarcoma (HP:0100243)1.59761731
66Uterine leiomyosarcoma (HP:0002891)1.59761731
67Abnormality of binocular vision (HP:0011514)1.57504487
68Diplopia (HP:0000651)1.57504487
69Abnormal ciliary motility (HP:0012262)1.56316292
70Basal ganglia calcification (HP:0002135)1.56286862
71Vertigo (HP:0002321)1.55439712
72Transitional cell carcinoma of the bladder (HP:0006740)1.53404481
73Abnormality of the prostate (HP:0008775)1.51218728
74Polyphagia (HP:0002591)1.50147713
75Testicular neoplasm (HP:0010788)1.46686155
76Dysostosis multiplex (HP:0000943)1.44223343
77Arthropathy (HP:0003040)1.42563935
78Chest pain (HP:0100749)1.42510036
79Central scotoma (HP:0000603)1.41257758
80Infertility (HP:0000789)1.40976895
81Bladder neoplasm (HP:0009725)1.38760645
82Bladder carcinoma (HP:0002862)1.38760645
83Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.38101582
84Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.37863403
85Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.37191866
86Abnormality of alanine metabolism (HP:0010916)1.37191866
87Hyperalaninemia (HP:0003348)1.37191866
88Lower limb amyotrophy (HP:0007210)1.34578540
89Thrombocytosis (HP:0001894)1.33341029
90Mucosal telangiectasiae (HP:0100579)1.31804158
91Thrombophlebitis (HP:0004418)1.31093875
92Mitral stenosis (HP:0001718)1.30596688
93Cerebral ischemia (HP:0002637)1.29711732
94Leukocytosis (HP:0001974)1.28439962
95Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.26060698
96Abnormality of the Achilles tendon (HP:0005109)1.25069365
97Cerebral hemorrhage (HP:0001342)1.24315477
98Hypertriglyceridemia (HP:0002155)1.24121876
99Abnormal respiratory epithelium morphology (HP:0012253)1.23149128
100Abnormal respiratory motile cilium morphology (HP:0005938)1.23149128

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.54366150
2MST45.03238858
3BMX4.40763460
4MYLK3.85272599
5EIF2AK13.63756624
6TEC3.28331326
7BTK2.86595493
8PTK2B2.65634762
9SYK2.23086331
10CSF1R2.17483232
11GRK52.14882597
12PIK3CG2.14637391
13ILK2.05726294
14TAOK32.01435868
15GRK61.94421500
16BMPR21.92371599
17ZAP701.91018273
18FGR1.76874874
19STK31.59483737
20ADRBK21.49853110
21HCK1.46483310
22BLK1.32647126
23MAPKAPK31.31378868
24PAK11.23342436
25PIM21.21980850
26FES1.21917357
27MAP2K31.20410219
28TNK21.18992801
29LMTK21.16743224
30STK241.14797101
31PLK21.13234965
32ACVR1B1.12233983
33DAPK31.10382582
34LYN1.10171761
35IKBKB1.05968506
36TNIK1.00622398
37SIK30.95493552
38IRAK10.91791120
39MATK0.89459992
40ITK0.88715833
41PNCK0.88401158
42ARAF0.87762681
43MAP3K50.86615621
44ADRBK10.86165673
45TRIM280.85780851
46EPHA30.85151580
47MARK30.84311764
48CSK0.82171588
49TXK0.81017589
50TAOK20.80208551
51PDK10.74971648
52RET0.70852654
53TAOK10.69688592
54PRKD10.69324923
55ERBB20.68275168
56PKN10.67262375
57IRAK40.65077433
58DAPK20.63065980
59EPHB20.62994909
60PDPK10.62757001
61MAP3K30.60349161
62FER0.58261844
63PDGFRB0.56952936
64PRKACG0.53275683
65STK40.50550681
66MAPK120.50485345
67MAP2K10.49676699
68MAP3K120.49340452
69TESK20.49273347
70TLK10.49145247
71BMPR1B0.46357765
72LCK0.46013224
73FYN0.45512533
74MINK10.45464542
75MAP3K110.45073572
76EPHB10.41845057
77YES10.41295754
78PRKG10.39957712
79JAK20.39649861
80IRAK20.38874143
81JAK30.38337215
82DAPK10.36910414
83JAK10.35969156
84CAMKK20.35817994
85SGK20.35161766
86MAPK130.34373757
87PRKCD0.33900339
88PAK30.32983284
89GRK10.31614037
90PIM10.30113050
91PRKCB0.29509503
92IRAK30.28648729
93PRKCQ0.28121235
94ROCK10.26924102
95SRC0.26685031
96NUAK10.26277533
97PRKCA0.25689871
98SGK30.24474556
99NLK0.23823971
100MAP4K10.23349307

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046115.68734921
2Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.70926854
3SNARE interactions in vesicular transport_Homo sapiens_hsa041302.98435525
4Hematopoietic cell lineage_Homo sapiens_hsa046402.53390784
5Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.52794330
6ECM-receptor interaction_Homo sapiens_hsa045122.46665168
7Arachidonic acid metabolism_Homo sapiens_hsa005902.08846129
8Nitrogen metabolism_Homo sapiens_hsa009101.92610824
9Gap junction_Homo sapiens_hsa045401.90380544
10Vascular smooth muscle contraction_Homo sapiens_hsa042701.67847566
11* Chemokine signaling pathway_Homo sapiens_hsa040621.66098868
12Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.63546063
13Serotonergic synapse_Homo sapiens_hsa047261.63247820
14Alcoholism_Homo sapiens_hsa050341.41151747
15Systemic lupus erythematosus_Homo sapiens_hsa053221.38680322
16Endocytosis_Homo sapiens_hsa041441.36030681
17Collecting duct acid secretion_Homo sapiens_hsa049661.35144081
18B cell receptor signaling pathway_Homo sapiens_hsa046621.32016095
19Shigellosis_Homo sapiens_hsa051311.30697371
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28558608
21Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.23070156
22Regulation of actin cytoskeleton_Homo sapiens_hsa048101.21671301
23Pancreatic secretion_Homo sapiens_hsa049721.20670482
24Glycerolipid metabolism_Homo sapiens_hsa005611.20107674
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.14864581
26Phospholipase D signaling pathway_Homo sapiens_hsa040721.11706065
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11486397
28Long-term depression_Homo sapiens_hsa047301.09080001
29Sulfur metabolism_Homo sapiens_hsa009201.05919025
30Fatty acid elongation_Homo sapiens_hsa000621.04367962
31T cell receptor signaling pathway_Homo sapiens_hsa046601.03887024
32Malaria_Homo sapiens_hsa051441.00876191
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.00002217
34Phagosome_Homo sapiens_hsa041450.99017456
35Olfactory transduction_Homo sapiens_hsa047400.96139254
36Osteoclast differentiation_Homo sapiens_hsa043800.94100454
37Linoleic acid metabolism_Homo sapiens_hsa005910.93692857
38Focal adhesion_Homo sapiens_hsa045100.92091880
39Rap1 signaling pathway_Homo sapiens_hsa040150.88663364
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88420226
41Circadian entrainment_Homo sapiens_hsa047130.86700260
42Morphine addiction_Homo sapiens_hsa050320.85761561
43Pancreatic cancer_Homo sapiens_hsa052120.83853153
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79692192
45Staphylococcus aureus infection_Homo sapiens_hsa051500.77558501
46Glutathione metabolism_Homo sapiens_hsa004800.77378211
47Toll-like receptor signaling pathway_Homo sapiens_hsa046200.76373477
48Choline metabolism in cancer_Homo sapiens_hsa052310.75125858
49Primary immunodeficiency_Homo sapiens_hsa053400.74268821
50* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70677295
51Non-small cell lung cancer_Homo sapiens_hsa052230.68218894
52Ras signaling pathway_Homo sapiens_hsa040140.64988796
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64380824
54Renin-angiotensin system_Homo sapiens_hsa046140.64242161
55Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62321393
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62096896
57Fat digestion and absorption_Homo sapiens_hsa049750.59537844
58Endometrial cancer_Homo sapiens_hsa052130.59524457
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59237172
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58429851
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58406924
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.58313981
63Dilated cardiomyopathy_Homo sapiens_hsa054140.58229038
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57984528
65Amoebiasis_Homo sapiens_hsa051460.57200702
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57188300
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56386271
68Viral carcinogenesis_Homo sapiens_hsa052030.56196772
69Calcium signaling pathway_Homo sapiens_hsa040200.56189780
70Starch and sucrose metabolism_Homo sapiens_hsa005000.55049171
71Graft-versus-host disease_Homo sapiens_hsa053320.53372654
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.53208518
73Small cell lung cancer_Homo sapiens_hsa052220.52781640
74GABAergic synapse_Homo sapiens_hsa047270.52218775
75Salmonella infection_Homo sapiens_hsa051320.51548560
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51307477
77Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50769341
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48998974
79Cholinergic synapse_Homo sapiens_hsa047250.48961662
80Glioma_Homo sapiens_hsa052140.48336008
81Gastric acid secretion_Homo sapiens_hsa049710.46919201
82Renal cell carcinoma_Homo sapiens_hsa052110.46791113
83Melanoma_Homo sapiens_hsa052180.46349289
84Mismatch repair_Homo sapiens_hsa034300.46060735
85Renin secretion_Homo sapiens_hsa049240.45488256
86Asthma_Homo sapiens_hsa053100.44678687
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44657533
88VEGF signaling pathway_Homo sapiens_hsa043700.43951522
89Phototransduction_Homo sapiens_hsa047440.43539613
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42719317
91Apoptosis_Homo sapiens_hsa042100.42656686
92Leishmaniasis_Homo sapiens_hsa051400.41275548
93beta-Alanine metabolism_Homo sapiens_hsa004100.41203775
94Sphingolipid metabolism_Homo sapiens_hsa006000.40024635
95Rheumatoid arthritis_Homo sapiens_hsa053230.39502873
96Allograft rejection_Homo sapiens_hsa053300.38886075
97Legionellosis_Homo sapiens_hsa051340.38223384
98Tuberculosis_Homo sapiens_hsa051520.37570837
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.37244017
100Oxytocin signaling pathway_Homo sapiens_hsa049210.36517753

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »