PFAS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Purines are necessary for many cellular processes, including DNA replication, transcription, and energy metabolism. Ten enzymatic steps are required to synthesize inosine monophosphate (IMP) in the de novo pathway of purine biosynthesis. The enzyme encoded by this gene catalyzes the fourth step of IMP biosynthesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA replication initiation (GO:0006270)5.19892368
2DNA strand elongation involved in DNA replication (GO:0006271)5.03039760
3telomere maintenance via semi-conservative replication (GO:0032201)4.98612848
4DNA strand elongation (GO:0022616)4.86161343
5nuclear pore organization (GO:0006999)4.80337084
6nuclear pore complex assembly (GO:0051292)4.72437774
7nucleobase biosynthetic process (GO:0046112)4.65388433
8kinetochore organization (GO:0051383)4.58152720
9DNA unwinding involved in DNA replication (GO:0006268)4.54397577
10regulation of translational fidelity (GO:0006450)4.53455487
11heterochromatin organization (GO:0070828)4.50285726
12CENP-A containing nucleosome assembly (GO:0034080)4.48295574
13chromatin remodeling at centromere (GO:0031055)4.47357152
14telomere maintenance via recombination (GO:0000722)4.43727917
15establishment of integrated proviral latency (GO:0075713)4.35274770
16negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.30393715
17mitotic recombination (GO:0006312)4.28581764
18protein localization to kinetochore (GO:0034501)4.19524937
19mitotic metaphase plate congression (GO:0007080)4.18851143
20* IMP biosynthetic process (GO:0006188)4.14092502
21DNA replication checkpoint (GO:0000076)4.12662867
22DNA replication-dependent nucleosome organization (GO:0034723)4.12546695
23DNA replication-dependent nucleosome assembly (GO:0006335)4.12546695
24purine nucleobase biosynthetic process (GO:0009113)4.10300277
25telomere maintenance via telomere lengthening (GO:0010833)4.05502960
26ribosomal small subunit assembly (GO:0000028)3.98011481
27protein complex localization (GO:0031503)3.96379458
28ribosome biogenesis (GO:0042254)3.94818990
29mitotic sister chromatid segregation (GO:0000070)3.91465642
30DNA replication-independent nucleosome assembly (GO:0006336)3.90731583
31DNA replication-independent nucleosome organization (GO:0034724)3.90731583
32nucleotide-excision repair, DNA gap filling (GO:0006297)3.90035114
33kinetochore assembly (GO:0051382)3.89561012
34meiotic chromosome segregation (GO:0045132)3.89254927
35L-serine metabolic process (GO:0006563)3.88113905
36mitotic nuclear envelope disassembly (GO:0007077)3.87743573
37pre-miRNA processing (GO:0031054)3.87454717
38pore complex assembly (GO:0046931)3.79612634
39negative regulation of mRNA processing (GO:0050686)3.76784690
40metaphase plate congression (GO:0051310)3.76370225
41mitotic sister chromatid cohesion (GO:0007064)3.75002326
42regulation of nuclear cell cycle DNA replication (GO:0033262)3.71863524
43peptidyl-arginine omega-N-methylation (GO:0035247)3.69737323
44histone arginine methylation (GO:0034969)3.68916402
45protein localization to chromosome, centromeric region (GO:0071459)3.64868379
46regulation of double-strand break repair via homologous recombination (GO:0010569)3.64276184
47chromatin assembly (GO:0031497)3.62824636
48sister chromatid segregation (GO:0000819)3.59561565
49negative regulation of mRNA metabolic process (GO:1903312)3.58306016
50histone exchange (GO:0043486)3.56271909
51establishment of chromosome localization (GO:0051303)3.54445806
52nuclear envelope disassembly (GO:0051081)3.51623203
53membrane disassembly (GO:0030397)3.51623203
54DNA duplex unwinding (GO:0032508)3.50655102
55negative regulation of RNA splicing (GO:0033119)3.50515015
56DNA geometric change (GO:0032392)3.50060268
57protein K6-linked ubiquitination (GO:0085020)3.47471038
58* IMP metabolic process (GO:0046040)3.47211482
59telomere maintenance (GO:0000723)3.44709521
60somatic diversification of immune receptors via somatic mutation (GO:0002566)3.43911161
61somatic hypermutation of immunoglobulin genes (GO:0016446)3.43911161
62telomere organization (GO:0032200)3.42380709
63non-recombinational repair (GO:0000726)3.41613508
64double-strand break repair via nonhomologous end joining (GO:0006303)3.41613508
65regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.40963354
66regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.40789261
67folic acid-containing compound biosynthetic process (GO:0009396)3.40668938
68regulation of histone H3-K9 methylation (GO:0051570)3.40487570
69RNA-dependent DNA replication (GO:0006278)3.31864420
70DNA deamination (GO:0045006)3.30792662
71DNA replication (GO:0006260)3.30738765
72spliceosomal tri-snRNP complex assembly (GO:0000244)3.29474323
73ribonucleoprotein complex biogenesis (GO:0022613)3.29316241
74mitotic chromosome condensation (GO:0007076)3.28637508
75transcription-coupled nucleotide-excision repair (GO:0006283)3.27381108
76inner cell mass cell proliferation (GO:0001833)3.27318515
77attachment of spindle microtubules to kinetochore (GO:0008608)3.26901548
78nucleosome disassembly (GO:0006337)3.26127611
79protein-DNA complex disassembly (GO:0032986)3.26127611
80cellular protein complex localization (GO:0034629)3.25454997
81regulation of posttranscriptional gene silencing (GO:0060147)3.22211926
82regulation of gene silencing by miRNA (GO:0060964)3.22211926
83regulation of gene silencing by RNA (GO:0060966)3.22211926
84establishment of viral latency (GO:0019043)3.21754845
85maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.21752076
86regulation of translational termination (GO:0006449)3.20751740
87DNA ligation (GO:0006266)3.20441223
88chromosome condensation (GO:0030261)3.16183281
89regulation of helicase activity (GO:0051095)3.15864255
90rRNA transcription (GO:0009303)3.15812366
91peptidyl-arginine methylation (GO:0018216)3.15798079
92peptidyl-arginine N-methylation (GO:0035246)3.15798079
93mismatch repair (GO:0006298)3.15597485
94spliceosomal snRNP assembly (GO:0000387)3.15163393
95formation of translation preinitiation complex (GO:0001731)3.11358913
96chromatin assembly or disassembly (GO:0006333)3.08104970
97snRNA processing (GO:0016180)3.02582478
98negative regulation of histone methylation (GO:0031061)3.02501608
99DNA-dependent DNA replication (GO:0006261)3.02500430
100viral mRNA export from host cell nucleus (GO:0046784)3.02450387
101DNA conformation change (GO:0071103)3.00704112
102regulation of chromosome segregation (GO:0051983)3.00577360
103nuclear envelope organization (GO:0006998)2.99310702
104DNA topological change (GO:0006265)2.99116966
105DNA synthesis involved in DNA repair (GO:0000731)2.98338367
106rRNA processing (GO:0006364)2.97682331
107ATP-dependent chromatin remodeling (GO:0043044)2.97550572
108intra-S DNA damage checkpoint (GO:0031573)2.97078347
109regulation of centrosome cycle (GO:0046605)2.96551601
110ribosomal large subunit biogenesis (GO:0042273)2.96451523
111ribosome assembly (GO:0042255)2.95158989
112regulation of sister chromatid cohesion (GO:0007063)2.94810144
113base-excision repair (GO:0006284)2.94558571
114pseudouridine synthesis (GO:0001522)2.94356897
115deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.93930849
116spindle checkpoint (GO:0031577)2.92660097
117deoxyribonucleotide biosynthetic process (GO:0009263)2.92351052
118chromosome segregation (GO:0007059)2.91900945
119ribosomal small subunit biogenesis (GO:0042274)2.91849102
120transcription from RNA polymerase I promoter (GO:0006360)2.91532714
121maturation of 5.8S rRNA (GO:0000460)2.91388784
122maturation of SSU-rRNA (GO:0030490)2.90430867
123rRNA modification (GO:0000154)2.90077040
124negative regulation of DNA-dependent DNA replication (GO:2000104)2.89481617
125negative regulation of chromosome segregation (GO:0051985)2.89051559
126mRNA transport (GO:0051028)2.88989336
127positive regulation of chromosome segregation (GO:0051984)2.88887215
128rRNA metabolic process (GO:0016072)2.88664950
129mitochondrial RNA metabolic process (GO:0000959)2.87525925
130regulation of RNA export from nucleus (GO:0046831)2.87503215
131regulation of spindle organization (GO:0090224)2.87051121
132DNA strand renaturation (GO:0000733)2.86042363
133negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.85938993
134negative regulation of sister chromatid segregation (GO:0033046)2.85938993
135negative regulation of mitotic sister chromatid separation (GO:2000816)2.85938993
136negative regulation of mitotic sister chromatid segregation (GO:0033048)2.85938993
137mRNA splicing, via spliceosome (GO:0000398)2.83194843
138RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.83194843
139tRNA aminoacylation for protein translation (GO:0006418)2.82460650
140folic acid metabolic process (GO:0046655)2.82229951

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F4_17652178_ChIP-ChIP_JURKAT_Human4.40843426
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.20996531
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.14516197
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.40438925
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.18584561
6MYC_19030024_ChIP-ChIP_MESCs_Mouse2.93091146
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.92224366
8* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.86796095
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.82013131
10MYC_18358816_ChIP-ChIP_MESCs_Mouse2.65594881
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.61143496
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.44556679
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.39775229
14* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.36269741
15* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.34804136
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.27871151
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.23125987
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.22140940
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.20525108
20E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.18673019
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.17300308
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.15662638
23AR_21909140_ChIP-Seq_LNCAP_Human2.06899162
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.01949318
25XRN2_22483619_ChIP-Seq_HELA_Human2.00393072
26* VDR_23849224_ChIP-Seq_CD4+_Human2.00171261
27E2F7_22180533_ChIP-Seq_HELA_Human10.9250734
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.94023170
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.91290412
30FOXP3_21729870_ChIP-Seq_TREG_Human1.88490865
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.88347166
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.87205216
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.87023810
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86732240
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83332395
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.83017397
37* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82511028
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82294766
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.80318966
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.79904110
41DCP1A_22483619_ChIP-Seq_HELA_Human1.73862994
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71467861
43ELK1_19687146_ChIP-ChIP_HELA_Human1.69212263
44SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.66544097
45TTF2_22483619_ChIP-Seq_HELA_Human1.65684978
46SOX2_18555785_ChIP-Seq_MESCs_Mouse1.63862172
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.63451776
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.59240896
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.57663919
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.57573321
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54615984
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.52659297
53CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.51675144
54CIITA_25753668_ChIP-Seq_RAJI_Human1.50057339
55GABP_19822575_ChIP-Seq_HepG2_Human1.49676662
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46549423
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.44093771
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38777889
59* SRF_21415370_ChIP-Seq_HL-1_Mouse1.35121714
60RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34747252
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33302159
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32541741
63* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.27968240
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27640258
65STAT3_1855785_ChIP-Seq_MESCs_Mouse1.27563017
66* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24275982
67* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22899175
68SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.22866377
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20884686
70KDM5A_27292631_Chip-Seq_BREAST_Human1.20784926
71VDR_21846776_ChIP-Seq_THP-1_Human1.20605488
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20039508
73MYC_22102868_ChIP-Seq_BL_Human1.18670384
74MYC_18940864_ChIP-ChIP_HL60_Human1.18368288
75KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14067357
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.13783247
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11730443
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11580728
79FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11324183
80NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.11236406
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10683592
82ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.08146413
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.06500369
84HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05982358
85* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04606484
86ZNF263_19887448_ChIP-Seq_K562_Human1.03780156
87NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.02203129
88KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.00885720
89KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.00885720
90KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.00885720
91FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99555408
92KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99471555
93SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97019853
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95509344
95TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94276834
96POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92767841
97TCF3_18692474_ChIP-Seq_MESCs_Mouse0.92640386
98SOX2_16153702_ChIP-ChIP_HESCs_Human0.91487692
99NANOG_16153702_ChIP-ChIP_HESCs_Human0.90226602
100IRF1_19129219_ChIP-ChIP_H3396_Human0.88017648
101PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.87840395
102CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.86811995
103SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.85638410
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85631559
105SOX17_20123909_ChIP-Seq_XEN_Mouse0.85382385
106KLF4_18555785_ChIP-Seq_MESCs_Mouse0.85350001
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85041329
108TFEB_21752829_ChIP-Seq_HELA_Human0.83282046
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83157261
110SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82897429
111NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.82680268
112CHD1_26751641_Chip-Seq_LNCaP_Human0.82334723
113FOXP1_21924763_ChIP-Seq_HESCs_Human0.81155416
114SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.79688610
115NANOG_21062744_ChIP-ChIP_HESCs_Human0.78751554
116ESR1_15608294_ChIP-ChIP_MCF-7_Human0.77681125
117POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.77265366

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.88800941
2MP0003693_abnormal_embryo_hatching4.83073604
3MP0008057_abnormal_DNA_replication4.79264581
4MP0003111_abnormal_nucleus_morphology4.34078885
5MP0004957_abnormal_blastocyst_morpholog3.82340370
6MP0003077_abnormal_cell_cycle3.65912068
7MP0008058_abnormal_DNA_repair3.62331200
8MP0008007_abnormal_cellular_replicative3.22402904
9MP0003786_premature_aging2.61116852
10MP0002396_abnormal_hematopoietic_system2.54710114
11MP0008932_abnormal_embryonic_tissue2.42938497
12MP0008877_abnormal_DNA_methylation2.31999671
13MP0003123_paternal_imprinting2.27231193
14MP0006292_abnormal_olfactory_placode2.25682171
15MP0000350_abnormal_cell_proliferation2.12254168
16MP0000537_abnormal_urethra_morphology2.08216417
17MP0001730_embryonic_growth_arrest1.95406753
18MP0002254_reproductive_system_inflammat1.91483820
19MP0000566_synostosis1.90422252
20MP0003315_abnormal_perineum_morphology1.87426992
21MP0003121_genomic_imprinting1.74016592
22MP0010307_abnormal_tumor_latency1.71672681
23MP0010352_gastrointestinal_tract_polyps1.69159232
24MP0001672_abnormal_embryogenesis/_devel1.61439262
25MP0005380_embryogenesis_phenotype1.61439262
26MP0000490_abnormal_crypts_of1.57648562
27MP0004233_abnormal_muscle_weight1.55297940
28MP0002697_abnormal_eye_size1.51415759
29MP0001697_abnormal_embryo_size1.49603960
30MP0003718_maternal_effect1.47480349
31MP0004197_abnormal_fetal_growth/weight/1.47260536
32MP0004808_abnormal_hematopoietic_stem1.46598625
33MP0001661_extended_life_span1.45234520
34MP0001293_anophthalmia1.45200132
35MP0003806_abnormal_nucleotide_metabolis1.42745272
36MP0010030_abnormal_orbit_morphology1.42236027
37MP0000313_abnormal_cell_death1.41564569
38MP0002085_abnormal_embryonic_tissue1.41039632
39MP0005075_abnormal_melanosome_morpholog1.39537930
40MP0003984_embryonic_growth_retardation1.37932260
41MP0004185_abnormal_adipocyte_glucose1.36571371
42MP0000015_abnormal_ear_pigmentation1.36349607
43MP0002088_abnormal_embryonic_growth/wei1.33601794
44MP0005367_renal/urinary_system_phenotyp1.33016983
45MP0000516_abnormal_urinary_system1.33016983
46MP0002080_prenatal_lethality1.28424324
47MP0002210_abnormal_sex_determination1.27953375
48MP0002877_abnormal_melanocyte_morpholog1.24480625
49MP0002160_abnormal_reproductive_system1.24284340
50MP0000428_abnormal_craniofacial_morphol1.24112605
51MP0002084_abnormal_developmental_patter1.23813539
52MP0001346_abnormal_lacrimal_gland1.23674088
53MP0003890_abnormal_embryonic-extraembry1.23273822
54MP0001188_hyperpigmentation1.21441218
55MP0003567_abnormal_fetal_cardiomyocyte1.20733195
56MP0003705_abnormal_hypodermis_morpholog1.18499768
57MP0002086_abnormal_extraembryonic_tissu1.17737561
58MP0002019_abnormal_tumor_incidence1.14896363
59MP0003941_abnormal_skin_development1.14461226
60MP0001119_abnormal_female_reproductive1.12193131
61MP0002163_abnormal_gland_morphology1.09915451
62MP0003763_abnormal_thymus_physiology1.08643763
63MP0001145_abnormal_male_reproductive1.03953360
64MP0003861_abnormal_nervous_system1.03373633
65MP0002132_abnormal_respiratory_system1.02841046
66MP0005389_reproductive_system_phenotype1.01721870
67MP0009278_abnormal_bone_marrow1.00826193
68MP0003136_yellow_coat_color1.00596478
69MP0003942_abnormal_urinary_system1.00569359
70MP0004133_heterotaxia1.00494672
71MP0005623_abnormal_meninges_morphology1.00130586
72MP0002095_abnormal_skin_pigmentation0.99287953
73MP0006035_abnormal_mitochondrial_morpho0.98988226
74MP0000358_abnormal_cell_content/0.96782091
75MP0000049_abnormal_middle_ear0.96698822
76MP0003119_abnormal_digestive_system0.95660647
77MP0002075_abnormal_coat/hair_pigmentati0.94368982
78MP0002009_preneoplasia0.93642828
79MP0001186_pigmentation_phenotype0.93387581
80MP0001919_abnormal_reproductive_system0.90690892
81MP0003937_abnormal_limbs/digits/tail_de0.90410983
82MP0000653_abnormal_sex_gland0.89776619
83MP0002089_abnormal_postnatal_growth/wei0.89603772
84MP0002111_abnormal_tail_morphology0.88972573
85MP0003385_abnormal_body_wall0.88967766
86MP0003787_abnormal_imprinting0.88866680
87MP0000703_abnormal_thymus_morphology0.88413856
88MP0005397_hematopoietic_system_phenotyp0.86554886
89MP0001545_abnormal_hematopoietic_system0.86554886
90MP0001929_abnormal_gametogenesis0.86378094
91MP0005408_hypopigmentation0.86031868
92MP0003115_abnormal_respiratory_system0.85959628
93MP0003186_abnormal_redox_activity0.84645355
94MP0009672_abnormal_birth_weight0.84311890
95MP0005409_darkened_coat_color0.84164669
96MP0009053_abnormal_anal_canal0.83740314
97MP0002751_abnormal_autonomic_nervous0.82184504
98MP0002398_abnormal_bone_marrow0.81279468
99MP0002938_white_spotting0.80777856
100MP0001915_intracranial_hemorrhage0.80551755
101MP0003935_abnormal_craniofacial_develop0.80090305
102MP0009333_abnormal_splenocyte_physiolog0.78771580
103MP0005076_abnormal_cell_differentiation0.78094193
104MP0001286_abnormal_eye_development0.77896012
105MP0009703_decreased_birth_body0.77020321
106MP0005384_cellular_phenotype0.76465204
107MP0000689_abnormal_spleen_morphology0.76083651
108MP0005174_abnormal_tail_pigmentation0.75973704
109MP0002233_abnormal_nose_morphology0.75410305
110MP0009697_abnormal_copulation0.75127088
111MP0000371_diluted_coat_color0.73455068
112MP0008789_abnormal_olfactory_epithelium0.73260961
113MP0005621_abnormal_cell_physiology0.72267970
114MP0008995_early_reproductive_senescence0.72065142
115MP0002722_abnormal_immune_system0.71745045
116MP0005394_taste/olfaction_phenotype0.71009549
117MP0005499_abnormal_olfactory_system0.71009549
118MP0003936_abnormal_reproductive_system0.70777876
119MP0008770_decreased_survivor_rate0.70519960
120MP0000432_abnormal_head_morphology0.70055008
121MP0002249_abnormal_larynx_morphology0.69744180
122MP0004782_abnormal_surfactant_physiolog0.69333809
123MP0000678_abnormal_parathyroid_gland0.69032621
124MP0002114_abnormal_axial_skeleton0.68043547
125MP0005501_abnormal_skin_physiology0.67476146
126MP0002081_perinatal_lethality0.67358289
127MP0001849_ear_inflammation0.67071450
128MP0002092_abnormal_eye_morphology0.66435944
129MP0005171_absent_coat_pigmentation0.65577933
130MP0005220_abnormal_exocrine_pancreas0.65111940
131MP0001299_abnormal_eye_distance/0.64654622
132MP0002116_abnormal_craniofacial_bone0.64186881
133MP0003699_abnormal_female_reproductive0.62454580
134MP0003755_abnormal_palate_morphology0.61956730
135MP0001348_abnormal_lacrimal_gland0.61482265
136MP0000579_abnormal_nail_morphology0.59493367

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.10481723
2Chromsome breakage (HP:0040012)5.07904378
3Birth length less than 3rd percentile (HP:0003561)4.84105550
4Abnormality of the anterior horn cell (HP:0006802)4.12143359
5Degeneration of anterior horn cells (HP:0002398)4.12143359
6Ectopic kidney (HP:0000086)3.70962020
7Meckel diverticulum (HP:0002245)3.44639357
8Carpal bone hypoplasia (HP:0001498)3.44399506
9Abnormality of chromosome stability (HP:0003220)3.43232258
10Rectovaginal fistula (HP:0000143)3.42722625
11Rectal fistula (HP:0100590)3.42722625
12Intestinal fistula (HP:0100819)3.42509407
13Abnormality of the ileum (HP:0001549)3.29310486
14Aplasia/Hypoplasia of the uvula (HP:0010293)3.25760672
15Abnormality of the preputium (HP:0100587)3.21821200
16Breast hypoplasia (HP:0003187)3.19990989
17Absent thumb (HP:0009777)3.19286766
18Impulsivity (HP:0100710)3.17631142
19Patellar aplasia (HP:0006443)3.17566347
20Absent radius (HP:0003974)3.09945747
21Selective tooth agenesis (HP:0001592)3.00852392
22Reticulocytopenia (HP:0001896)3.00181460
23Absent forearm bone (HP:0003953)2.92094777
24Aplasia involving forearm bones (HP:0009822)2.92094777
25Aplasia/Hypoplasia of the patella (HP:0006498)2.90903311
26Abnormal lung lobation (HP:0002101)2.90753829
27Progressive muscle weakness (HP:0003323)2.89817739
28Medulloblastoma (HP:0002885)2.85716128
29Abnormality of the labia minora (HP:0012880)2.84076275
30Nephroblastoma (Wilms tumor) (HP:0002667)2.79812988
31Supernumerary spleens (HP:0009799)2.78788906
32Myelodysplasia (HP:0002863)2.75987384
33High anterior hairline (HP:0009890)2.75572138
3411 pairs of ribs (HP:0000878)2.75188654
35Vaginal fistula (HP:0004320)2.74075232
36Duplicated collecting system (HP:0000081)2.73820640
37Duodenal stenosis (HP:0100867)2.71852037
38Small intestinal stenosis (HP:0012848)2.71852037
39Hyperacusis (HP:0010780)2.68987490
40Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.67001136
41Ependymoma (HP:0002888)2.62574291
42Abnormality of the renal collecting system (HP:0004742)2.61755925
43Stenosis of the external auditory canal (HP:0000402)2.60434618
44Embryonal renal neoplasm (HP:0011794)2.59590003
45Type I transferrin isoform profile (HP:0003642)2.50749007
46Multiple enchondromatosis (HP:0005701)2.46477048
47Clubbing of toes (HP:0100760)2.45975698
48Aplastic anemia (HP:0001915)2.45951487
49Bone marrow hypocellularity (HP:0005528)2.44752264
50Abnormality of the duodenum (HP:0002246)2.43213876
51Colon cancer (HP:0003003)2.42044465
52Optic nerve coloboma (HP:0000588)2.41912451
53Abnormality of cochlea (HP:0000375)2.38942910
54Agnosia (HP:0010524)2.37977224
55Sloping forehead (HP:0000340)2.37257235
56Horseshoe kidney (HP:0000085)2.35694130
57Triphalangeal thumb (HP:0001199)2.34150036
58Spastic diplegia (HP:0001264)2.33965279
59Aplasia/hypoplasia of the humerus (HP:0006507)2.32097301
60Proximal placement of thumb (HP:0009623)2.31011771
61Anal stenosis (HP:0002025)2.30556201
62Deviation of the thumb (HP:0009603)2.29725734
63Abnormality of the carotid arteries (HP:0005344)2.29218525
64Short thumb (HP:0009778)2.27323494
65Premature graying of hair (HP:0002216)2.26796037
66Oral leukoplakia (HP:0002745)2.26732293
67Urethral obstruction (HP:0000796)2.26262436
68Abnormal number of erythroid precursors (HP:0012131)2.26191040
69Abnormal number of incisors (HP:0011064)2.25336672
70Intestinal atresia (HP:0011100)2.22719188
71Homocystinuria (HP:0002156)2.16477162
72Abnormality of homocysteine metabolism (HP:0010919)2.16477162
73Abnormality of DNA repair (HP:0003254)2.15528970
74Broad distal phalanx of finger (HP:0009836)2.14803838
75Abnormality of cells of the erythroid lineage (HP:0012130)2.12771491
76Progressive external ophthalmoplegia (HP:0000590)2.11182371
77Asplenia (HP:0001746)2.10867376
78Short humerus (HP:0005792)2.10587563
79Bilateral microphthalmos (HP:0007633)2.08876215
80Skull defect (HP:0001362)2.06792812
81Cutaneous melanoma (HP:0012056)2.06263221
82Hypoplasia of the capital femoral epiphysis (HP:0003090)2.05942483
83Tracheoesophageal fistula (HP:0002575)2.03227860
84Facial cleft (HP:0002006)2.01649227
85Overriding aorta (HP:0002623)2.00891069
86Neoplasm of the adrenal cortex (HP:0100641)1.99971699
87Rhabdomyosarcoma (HP:0002859)1.97789532
88Trigonocephaly (HP:0000243)1.97486638
89High pitched voice (HP:0001620)1.97055971
90Abnormality of pyrimidine metabolism (HP:0004353)1.96874696
91Aplasia/Hypoplasia of the spleen (HP:0010451)1.96128964
92Missing ribs (HP:0000921)1.95870969
93Choanal atresia (HP:0000453)1.89571868
94Short 1st metacarpal (HP:0010034)1.88777215
95Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.88777215
96Increased nuchal translucency (HP:0010880)1.88405958
97Aplasia/Hypoplasia of the sternum (HP:0006714)1.86460225
98Amaurosis fugax (HP:0100576)1.84661175
99Spinal cord lesions (HP:0100561)1.84479003
100Syringomyelia (HP:0003396)1.84479003
101Absent epiphyses (HP:0010577)1.84020026
102Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.84020026
103Atrophy/Degeneration involving motor neurons (HP:0007373)1.83422739
104Elfin facies (HP:0004428)1.83375792
105Volvulus (HP:0002580)1.83179389
106Duplication of thumb phalanx (HP:0009942)1.82739115
107Partial agenesis of the corpus callosum (HP:0001338)1.82657045
108Cortical dysplasia (HP:0002539)1.81604837
109Neoplasm of the pancreas (HP:0002894)1.81443446
110Hypoplasia of the radius (HP:0002984)1.80504940
111Glioma (HP:0009733)1.79943740
112Cafe-au-lait spot (HP:0000957)1.79877830
113Broad thumb (HP:0011304)1.79034772
114Trismus (HP:0000211)1.78802068
115Preauricular skin tag (HP:0000384)1.77246265
116Preaxial hand polydactyly (HP:0001177)1.77199806
117Renal duplication (HP:0000075)1.76390554
118Abnormality of the calcaneus (HP:0008364)1.75433503
119Microvesicular hepatic steatosis (HP:0001414)1.75011227
120Lymphoma (HP:0002665)1.74165224
121Deep philtrum (HP:0002002)1.73770002
122Morphological abnormality of the inner ear (HP:0011390)1.73706276
123Insomnia (HP:0100785)1.73403118
124Ulnar bowing (HP:0003031)1.73182994
125Aplasia/Hypoplasia of the sacrum (HP:0008517)1.71278333
126Spinal muscular atrophy (HP:0007269)1.69899845
127Atresia of the external auditory canal (HP:0000413)1.69666353
128Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.69322852
129Short 4th metacarpal (HP:0010044)1.69322852
130Embryonal neoplasm (HP:0002898)1.69062745
131Squamous cell carcinoma (HP:0002860)1.68959353
132Pseudobulbar signs (HP:0002200)1.68577519
133Rib fusion (HP:0000902)1.67750905
134Astrocytoma (HP:0009592)1.67710860
135Abnormality of the astrocytes (HP:0100707)1.67710860
136Rough bone trabeculation (HP:0100670)1.66385352
137Cellular immunodeficiency (HP:0005374)1.65526629
138Arteriovenous malformation (HP:0100026)1.65483848
139Acute lymphatic leukemia (HP:0006721)1.64164072
140Abnormality of reticulocytes (HP:0004312)1.63511713
141Premature ovarian failure (HP:0008209)1.62518664
142Cleft eyelid (HP:0000625)1.60847953
143Abnormality of abdominal situs (HP:0011620)1.60130090
144Abdominal situs inversus (HP:0003363)1.60130090
145Esophageal atresia (HP:0002032)1.57986646

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.32487490
2SMG14.05409103
3SRPK13.98977889
4MKNK13.82473070
5EIF2AK13.20037580
6MKNK23.12969350
7VRK23.05331987
8BUB13.03911491
9WEE13.02224338
10MAP3K102.93471207
11ZAK2.47541829
12CDK122.35303813
13TAF12.33344093
14TSSK62.31907821
15PASK2.28106635
16VRK12.16921851
17TTK2.16735556
18ICK2.07335946
19PLK32.06463958
20PLK42.05463875
21EIF2AK32.04823124
22ATR1.98928367
23BRD41.94738000
24PLK11.94123453
25NEK21.91230477
26BRSK21.90374320
27TLK11.81796037
28NEK11.72479611
29CDK71.67927815
30TRIB31.63007629
31EIF2AK21.54048125
32CHEK21.51162495
33AKT31.47684329
34AURKB1.46820379
35ACVR1B1.45198617
36RPS6KB21.35108162
37EPHA21.34292902
38STK161.33129367
39CCNB11.30252210
40STK41.27992011
41CDK41.22621502
42NEK61.22310174
43CHEK11.22004176
44CLK11.21455919
45KDR1.20803667
46YES11.14993740
47AURKA1.10792489
48NME11.05705621
49PIM11.05068749
50STK38L1.04759617
51ATM1.03514407
52BRSK11.02537310
53MAP3K80.99402755
54CAMK1D0.95986302
55ERBB30.95001187
56EEF2K0.94001457
57CDK20.93122746
58STK100.92490404
59MAP3K140.89714951
60CDK80.88159024
61MTOR0.87035602
62NME20.85035395
63PRPF4B0.81407532
64FGFR40.78293517
65CAMK1G0.77665229
66TTN0.74133938
67BRAF0.73858775
68TGFBR10.73788779
69ALK0.73023171
70CDK10.71659012
71CSNK2A10.70700966
72CSNK2A20.69681335
73PBK0.65339012
74IRAK40.65122223
75LATS20.65080164
76MAP3K90.64998206
77RPS6KA50.63245549
78FGFR10.62366721
79RPS6KB10.62302553
80MAPKAPK50.62279491
81RPS6KA40.60994051
82FLT30.60616493
83DYRK30.59953841
84MAPK110.59407745
85TXK0.57191172
86TEC0.55174463
87CDK60.53246985
88SCYL20.52603009
89DAPK10.51866824
90NUAK10.50910559
91ERBB40.48848799
92SGK20.48609587
93STK240.47356563
94BMX0.47082526
95MAPK140.45536157
96CHUK0.45461672
97SIK10.44016229
98PAK40.43839278
99CSNK1G10.43428544
100PRKCI0.41704510
101IRAK30.40067270
102MELK0.39925818
103RPS6KA10.39615348
104BTK0.39268580
105PLK20.39210380
106PRKDC0.38633673
107CSNK1G30.38509817
108JAK30.36620698
109PAK20.35309381
110CDK11A0.34512618
111PDK20.33387094
112AKT10.32866899
113TRPM70.32825450
114TNK20.32625776
115PDGFRA0.32550930
116CDK150.32062205
117SIK30.31838217
118CSNK1A1L0.31817151
119RPS6KL10.30014888
120RPS6KC10.30014888
121AKT20.29923313
122MAP2K20.29723318
123PNCK0.29354737
124DYRK20.28897138
125DAPK30.28816081
126MAP4K10.28597400
127GSK3B0.28007518
128RPS6KA60.27735832
129MAP2K30.26427853
130GRK10.26307334
131PAK10.25503223
132STK30.25454774
133TESK20.24704344
134CDK90.24391702
135CSNK1E0.24355696
136CSNK1D0.23516480

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.41508588
2Mismatch repair_Homo sapiens_hsa034304.63383532
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.85013763
4One carbon pool by folate_Homo sapiens_hsa006703.45800203
5Base excision repair_Homo sapiens_hsa034103.43878996
6Homologous recombination_Homo sapiens_hsa034403.40910180
7Spliceosome_Homo sapiens_hsa030403.26433108
8RNA polymerase_Homo sapiens_hsa030203.04981234
9Nucleotide excision repair_Homo sapiens_hsa034203.01226612
10RNA transport_Homo sapiens_hsa030132.99548774
11Fanconi anemia pathway_Homo sapiens_hsa034602.84789680
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.78978809
13Cell cycle_Homo sapiens_hsa041102.70266126
14Pyrimidine metabolism_Homo sapiens_hsa002402.45945257
15Ribosome_Homo sapiens_hsa030102.36575401
16Non-homologous end-joining_Homo sapiens_hsa034502.36452025
17Proteasome_Homo sapiens_hsa030502.29331355
18RNA degradation_Homo sapiens_hsa030182.10279577
19Basal transcription factors_Homo sapiens_hsa030222.01732711
20mRNA surveillance pathway_Homo sapiens_hsa030151.95674119
21Systemic lupus erythematosus_Homo sapiens_hsa053221.67054898
22p53 signaling pathway_Homo sapiens_hsa041151.46114522
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.43002659
24* Purine metabolism_Homo sapiens_hsa002301.40320427
25Sulfur relay system_Homo sapiens_hsa041221.30567793
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23985126
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11498197
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10421197
29Herpes simplex infection_Homo sapiens_hsa051681.00006526
30Epstein-Barr virus infection_Homo sapiens_hsa051690.99699959
31Viral carcinogenesis_Homo sapiens_hsa052030.97886624
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.94016818
33Pyruvate metabolism_Homo sapiens_hsa006200.93925697
34Selenocompound metabolism_Homo sapiens_hsa004500.89263722
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87140106
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87088505
37Thyroid cancer_Homo sapiens_hsa052160.83224131
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78641474
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74663913
40Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74641689
41HTLV-I infection_Homo sapiens_hsa051660.73764250
42Alcoholism_Homo sapiens_hsa050340.71440946
43Oocyte meiosis_Homo sapiens_hsa041140.71311685
44MicroRNAs in cancer_Homo sapiens_hsa052060.70624171
45Cyanoamino acid metabolism_Homo sapiens_hsa004600.70310245
46Antigen processing and presentation_Homo sapiens_hsa046120.68533829
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.68215792
48Arachidonic acid metabolism_Homo sapiens_hsa005900.59825436
49N-Glycan biosynthesis_Homo sapiens_hsa005100.57862608
50Adherens junction_Homo sapiens_hsa045200.57658925
51Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57188981
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56637765
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.54849302
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52991820
55Protein export_Homo sapiens_hsa030600.52882309
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52196494
57Small cell lung cancer_Homo sapiens_hsa052220.51117403
58Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50670259
59Basal cell carcinoma_Homo sapiens_hsa052170.50079982
60Legionellosis_Homo sapiens_hsa051340.49600963
61Steroid biosynthesis_Homo sapiens_hsa001000.48771016
62Hedgehog signaling pathway_Homo sapiens_hsa043400.48233953
63Measles_Homo sapiens_hsa051620.47496349
64Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47429388
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44899544
66Biosynthesis of amino acids_Homo sapiens_hsa012300.42371832
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.42123195
68Primary immunodeficiency_Homo sapiens_hsa053400.42027113
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41376307
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39919842
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39568942
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.38999429
73Galactose metabolism_Homo sapiens_hsa000520.35969641
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35842853
75Notch signaling pathway_Homo sapiens_hsa043300.34973064
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32976347
77Influenza A_Homo sapiens_hsa051640.32679169
78Glutathione metabolism_Homo sapiens_hsa004800.32250638
79Apoptosis_Homo sapiens_hsa042100.31186453
80Fructose and mannose metabolism_Homo sapiens_hsa000510.30774700
81Endometrial cancer_Homo sapiens_hsa052130.30550535
82Arginine and proline metabolism_Homo sapiens_hsa003300.30301768
83Pancreatic cancer_Homo sapiens_hsa052120.30031160
84Hippo signaling pathway_Homo sapiens_hsa043900.29466869
85TGF-beta signaling pathway_Homo sapiens_hsa043500.29217963
86Vitamin B6 metabolism_Homo sapiens_hsa007500.29045152
87Huntingtons disease_Homo sapiens_hsa050160.28564864
88Arginine biosynthesis_Homo sapiens_hsa002200.28216497
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27921572
90Pentose phosphate pathway_Homo sapiens_hsa000300.27846737
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27821220
92Hepatitis B_Homo sapiens_hsa051610.26320797
93Fatty acid metabolism_Homo sapiens_hsa012120.25271159
94Allograft rejection_Homo sapiens_hsa053300.24480553
95Hematopoietic cell lineage_Homo sapiens_hsa046400.23255702
96Vitamin digestion and absorption_Homo sapiens_hsa049770.22779025
97Fatty acid elongation_Homo sapiens_hsa000620.22727223
98Melanoma_Homo sapiens_hsa052180.22500152
99Pathways in cancer_Homo sapiens_hsa052000.21101975
100Lysine degradation_Homo sapiens_hsa003100.20419134
101Acute myeloid leukemia_Homo sapiens_hsa052210.20155018
102Prostate cancer_Homo sapiens_hsa052150.19989953
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.19219623
104Intestinal immune network for IgA production_Homo sapiens_hsa046720.18773829
105AMPK signaling pathway_Homo sapiens_hsa041520.18389906
106Asthma_Homo sapiens_hsa053100.17864626
107Tight junction_Homo sapiens_hsa045300.17778289
108Fatty acid biosynthesis_Homo sapiens_hsa000610.17068330
109* Metabolic pathways_Homo sapiens_hsa011000.16841120
110Folate biosynthesis_Homo sapiens_hsa007900.16495775
111Chronic myeloid leukemia_Homo sapiens_hsa052200.16287138
112Colorectal cancer_Homo sapiens_hsa052100.16096164
113Autoimmune thyroid disease_Homo sapiens_hsa053200.15201436
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.14162464
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.12398256
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.11743254
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.11427629
118Wnt signaling pathway_Homo sapiens_hsa043100.11138268
119Non-small cell lung cancer_Homo sapiens_hsa052230.10843319
120HIF-1 signaling pathway_Homo sapiens_hsa040660.10674714
121Bladder cancer_Homo sapiens_hsa052190.10189776
122Carbon metabolism_Homo sapiens_hsa012000.08952061
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.08569399
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.08541101
125Linoleic acid metabolism_Homo sapiens_hsa005910.07439927
126NOD-like receptor signaling pathway_Homo sapiens_hsa046210.07261695
127RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.07157571

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