PFDN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.78546808
2energy coupled proton transport, down electrochemical gradient (GO:0015985)6.31641349
3ATP synthesis coupled proton transport (GO:0015986)6.31641349
4ribosomal small subunit assembly (GO:0000028)6.08562763
5viral transcription (GO:0019083)5.92375481
6ribosomal small subunit biogenesis (GO:0042274)5.84279358
7translational termination (GO:0006415)5.77658724
8maturation of SSU-rRNA (GO:0030490)5.44225505
9mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.38412106
10ribosomal large subunit biogenesis (GO:0042273)5.19010544
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.18591330
12cotranslational protein targeting to membrane (GO:0006613)5.14307481
13translational elongation (GO:0006414)5.09134031
14protein targeting to ER (GO:0045047)5.08961862
15proteasome assembly (GO:0043248)5.06032426
16respiratory electron transport chain (GO:0022904)5.01192354
17electron transport chain (GO:0022900)4.89860074
18cullin deneddylation (GO:0010388)4.85173185
19establishment of protein localization to endoplasmic reticulum (GO:0072599)4.83214558
20protein localization to endoplasmic reticulum (GO:0070972)4.81936891
21cellular protein complex disassembly (GO:0043624)4.69106829
22viral life cycle (GO:0019058)4.63985584
23establishment of protein localization to mitochondrial membrane (GO:0090151)4.63844294
24translational initiation (GO:0006413)4.63774465
25protein neddylation (GO:0045116)4.55945928
26protein deneddylation (GO:0000338)4.50556524
27translation (GO:0006412)4.37995743
28nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.36369923
29regulation of mitochondrial translation (GO:0070129)4.28470690
30termination of RNA polymerase III transcription (GO:0006386)4.18344662
31transcription elongation from RNA polymerase III promoter (GO:0006385)4.18344662
32protein complex biogenesis (GO:0070271)4.17668102
33negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.15068009
34GTP biosynthetic process (GO:0006183)4.13704862
35ribonucleoprotein complex biogenesis (GO:0022613)4.07213386
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.06892246
37mitochondrial respiratory chain complex I assembly (GO:0032981)4.06892246
38NADH dehydrogenase complex assembly (GO:0010257)4.06892246
39protein complex disassembly (GO:0043241)4.02598962
40mitochondrial respiratory chain complex assembly (GO:0033108)3.99695115
41establishment of integrated proviral latency (GO:0075713)3.94410247
42macromolecular complex disassembly (GO:0032984)3.89420135
43oxidative phosphorylation (GO:0006119)3.88113219
44positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.87452936
45regulation of cellular amino acid metabolic process (GO:0006521)3.85127387
46chaperone-mediated protein transport (GO:0072321)3.84699697
47negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.82577086
48negative regulation of ligase activity (GO:0051352)3.82577086
49cellular component biogenesis (GO:0044085)3.81236835
50DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.80250140
51formation of translation preinitiation complex (GO:0001731)3.78019089
527-methylguanosine mRNA capping (GO:0006370)3.76018806
53UTP biosynthetic process (GO:0006228)3.74870635
54regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.74608901
55DNA deamination (GO:0045006)3.72633300
56DNA damage response, detection of DNA damage (GO:0042769)3.71845925
57nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.71562109
58intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.71558853
59signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.71558853
60signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.68539769
61signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.68539769
62signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.68539769
63spliceosomal snRNP assembly (GO:0000387)3.68101970
64anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.68073450
657-methylguanosine RNA capping (GO:0009452)3.67905236
66RNA capping (GO:0036260)3.67905236
67signal transduction involved in DNA integrity checkpoint (GO:0072401)3.66639523
68signal transduction involved in DNA damage checkpoint (GO:0072422)3.66639523
69signal transduction involved in cell cycle checkpoint (GO:0072395)3.63761965
70exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.62002650
71RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.61939838
72tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.61939838
73spliceosomal complex assembly (GO:0000245)3.61871886
74establishment of protein localization to mitochondrion (GO:0072655)3.57450367
75guanosine-containing compound biosynthetic process (GO:1901070)3.57167219
76L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.56992553
77protein targeting to mitochondrion (GO:0006626)3.47412006
78rRNA modification (GO:0000154)3.44905866
79positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.43584714
80rRNA processing (GO:0006364)3.43258221
81purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.42400927
82establishment of viral latency (GO:0019043)3.40846439
83antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.40349265
84purine nucleoside triphosphate biosynthetic process (GO:0009145)3.36211407
85transcription-coupled nucleotide-excision repair (GO:0006283)3.35911158
86protein targeting to membrane (GO:0006612)3.29798097
87protein localization to mitochondrion (GO:0070585)3.29449802
88rRNA metabolic process (GO:0016072)3.28675114
89pseudouridine synthesis (GO:0001522)3.28561063
90respiratory chain complex IV assembly (GO:0008535)3.26649844
91positive regulation of ligase activity (GO:0051351)3.26313329
92ATP biosynthetic process (GO:0006754)3.22028374
93nuclear-transcribed mRNA catabolic process (GO:0000956)3.20177990
94mitochondrial transport (GO:0006839)3.16390177
95UTP metabolic process (GO:0046051)3.15581986
96sequestering of actin monomers (GO:0042989)3.15045790
97cytochrome complex assembly (GO:0017004)3.13871733
98inner mitochondrial membrane organization (GO:0007007)3.12768840
99transcription from RNA polymerase I promoter (GO:0006360)3.12438044
100antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.12203665
101CENP-A containing nucleosome assembly (GO:0034080)3.11938939
102chromatin remodeling at centromere (GO:0031055)3.10844388
103proton transport (GO:0015992)3.10346352
104ribonucleoside triphosphate biosynthetic process (GO:0009201)3.09258461
105pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.08696188
106protein-cofactor linkage (GO:0018065)3.08210126
107viral mRNA export from host cell nucleus (GO:0046784)3.08146620
108regulation of ligase activity (GO:0051340)3.05781150
109telomere maintenance via semi-conservative replication (GO:0032201)3.05736319
110hydrogen transport (GO:0006818)3.04299905
111nucleobase-containing small molecule interconversion (GO:0015949)3.02906317
112regulation of ubiquitin-protein transferase activity (GO:0051438)3.02208375
113hydrogen ion transmembrane transport (GO:1902600)3.02162842
114intracellular protein transmembrane import (GO:0044743)3.00051446
115deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.95255100
116pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.92643136
117negative regulation of protein ubiquitination (GO:0031397)2.92551034
118regulation of cellular amine metabolic process (GO:0033238)2.89699706
119protein K11-linked ubiquitination (GO:0070979)2.88344437
120platelet dense granule organization (GO:0060155)2.86167756
121organelle disassembly (GO:1903008)2.81175840
122aerobic respiration (GO:0009060)2.78660547
123positive regulation of cell cycle arrest (GO:0071158)2.76868713

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.62359832
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.51412475
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.19395608
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.06291360
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.90462343
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.70626616
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.63980724
8* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.57404706
9E2F7_22180533_ChIP-Seq_HELA_Human3.50671371
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.49762255
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.36647967
12* CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.30030503
13MYC_19079543_ChIP-ChIP_MESCs_Mouse3.19984537
14MYC_18358816_ChIP-ChIP_MESCs_Mouse3.15468591
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.10792357
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.99939615
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.99076593
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.94590479
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.68925971
20XRN2_22483619_ChIP-Seq_HELA_Human2.53438493
21* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.47819827
22DCP1A_22483619_ChIP-Seq_HELA_Human2.42416555
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.39122353
24VDR_23849224_ChIP-Seq_CD4+_Human2.38831223
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.28100231
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.26701343
27YY1_21170310_ChIP-Seq_MESCs_Mouse2.22347975
28TTF2_22483619_ChIP-Seq_HELA_Human2.21573603
29E2F4_17652178_ChIP-ChIP_JURKAT_Human2.19836037
30ELK1_19687146_ChIP-ChIP_HELA_Human2.17558499
31* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.17452976
32SRF_21415370_ChIP-Seq_HL-1_Mouse2.17439567
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.13343612
34PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.08343556
35FOXP3_21729870_ChIP-Seq_TREG_Human2.03798163
36GABP_19822575_ChIP-Seq_HepG2_Human1.93851118
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.91640244
38POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.89933591
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.88864642
40RBPJ_22232070_ChIP-Seq_NCS_Mouse1.86418253
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83360553
42MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79617482
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.74289380
44CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.67754953
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58594641
46* ELK1_22589737_ChIP-Seq_MCF10A_Human1.57887396
47ZNF274_21170338_ChIP-Seq_K562_Hela1.55640232
48* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52582150
49KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.51572254
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.50540640
51SOX2_18555785_ChIP-Seq_MESCs_Mouse1.49171016
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.48879462
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.44212814
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44159559
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40668678
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.39981457
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39201499
58MYC_18940864_ChIP-ChIP_HL60_Human1.36214352
59* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.33869639
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29535079
61BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.29151996
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25705973
63NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20516682
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19425146
65CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19188986
66SOX2_18692474_ChIP-Seq_MEFs_Mouse1.19120125
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16585909
68ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.16116589
69EWS_26573619_Chip-Seq_HEK293_Human1.15202214
70VDR_22108803_ChIP-Seq_LS180_Human1.14365548
71OCT4_18692474_ChIP-Seq_MEFs_Mouse1.13617384
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11856625
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11466142
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.09870237
75SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09806650
76TCF3_18692474_ChIP-Seq_MEFs_Mouse1.09158953
77SOX17_20123909_ChIP-Seq_XEN_Mouse1.08246858
78NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.07199856
79KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.06069699
80KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.06069699
81KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.06069699
82FOXM1_23109430_ChIP-Seq_U2OS_Human1.03131772
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.01404208
84NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.00949636
85SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.00648911
86HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98790101
87SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98410921
88CTCF_18555785_ChIP-Seq_MESCs_Mouse0.97207993
89AR_21909140_ChIP-Seq_LNCAP_Human0.96870753
90* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96065215
91E2F1_21310950_ChIP-Seq_MCF-7_Human0.93883923
92SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.93392836
93ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92634645
94HTT_18923047_ChIP-ChIP_STHdh_Human0.92199596
95SOX2_16153702_ChIP-ChIP_HESCs_Human0.92052758
96* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.90594705
97TP53_22573176_ChIP-Seq_HFKS_Human0.87844358
98FUS_26573619_Chip-Seq_HEK293_Human0.87364894
99NANOG_16153702_ChIP-ChIP_HESCs_Human0.87336774
100E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87093216
101IRF1_19129219_ChIP-ChIP_H3396_Human0.87072552
102KDM5A_27292631_Chip-Seq_BREAST_Human0.86080129
103CIITA_25753668_ChIP-Seq_RAJI_Human0.84374059
104CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.82650748
105NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.81317513
106IGF1R_20145208_ChIP-Seq_DFB_Human0.80698336
107HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.80346564
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79833386
109* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.78469019
110FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.76736983
111POU5F1_16153702_ChIP-ChIP_HESCs_Human0.75726900
112KLF4_18555785_ChIP-Seq_MESCs_Mouse0.74693598
113NANOG_21062744_ChIP-ChIP_HESCs_Human0.73916304
114SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.73859032
115NOTCH1_21737748_ChIP-Seq_TLL_Human0.72463673
116CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.72453938
117PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.72186859
118EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.71756119
119MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.70334400
120ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.68466022
121TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.66057866

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.24898950
2MP0003693_abnormal_embryo_hatching3.65807261
3MP0004957_abnormal_blastocyst_morpholog3.50404680
4MP0008932_abnormal_embryonic_tissue2.89954699
5MP0003136_yellow_coat_color2.62892147
6MP0010094_abnormal_chromosome_stability2.37845891
7MP0003718_maternal_effect2.35281453
8MP0003123_paternal_imprinting2.32081844
9MP0008058_abnormal_DNA_repair2.30252214
10MP0003806_abnormal_nucleotide_metabolis2.29913653
11MP0003077_abnormal_cell_cycle2.29181650
12MP0001529_abnormal_vocalization2.26565358
13MP0003315_abnormal_perineum_morphology2.23429282
14MP0003111_abnormal_nucleus_morphology2.16698830
15MP0003941_abnormal_skin_development2.04042278
16MP0010030_abnormal_orbit_morphology2.02805002
17MP0003186_abnormal_redox_activity1.97855542
18MP0008789_abnormal_olfactory_epithelium1.96431774
19MP0006036_abnormal_mitochondrial_physio1.94465099
20MP0003786_premature_aging1.91917073
21MP0004133_heterotaxia1.89613986
22MP0008877_abnormal_DNA_methylation1.83353005
23MP0008007_abnormal_cellular_replicative1.77124044
24MP0006035_abnormal_mitochondrial_morpho1.76856585
25MP0006292_abnormal_olfactory_placode1.72191464
26MP0008057_abnormal_DNA_replication1.72170470
27MP0005423_abnormal_somatic_nervous1.72090309
28MP0002751_abnormal_autonomic_nervous1.61847412
29MP0005084_abnormal_gallbladder_morpholo1.61065585
30MP0003646_muscle_fatigue1.59991736
31MP0003122_maternal_imprinting1.56276671
32MP0009046_muscle_twitch1.56059403
33MP0000749_muscle_degeneration1.52889464
34MP0002653_abnormal_ependyma_morphology1.52450754
35MP0000049_abnormal_middle_ear1.51760191
36MP0001188_hyperpigmentation1.48514980
37MP0001905_abnormal_dopamine_level1.48489217
38MP0005394_taste/olfaction_phenotype1.43525446
39MP0005499_abnormal_olfactory_system1.43525446
40MP0002160_abnormal_reproductive_system1.42346616
41MP0002638_abnormal_pupillary_reflex1.41038901
42MP0002132_abnormal_respiratory_system1.40583557
43MP0000372_irregular_coat_pigmentation1.40453246
44MP0001984_abnormal_olfaction1.40016969
45MP0002163_abnormal_gland_morphology1.37860842
46MP0003787_abnormal_imprinting1.37612436
47MP0006276_abnormal_autonomic_nervous1.35615725
48MP0008995_early_reproductive_senescence1.34781947
49MP0002837_dystrophic_cardiac_calcinosis1.34774690
50MP0003121_genomic_imprinting1.33106949
51MP0002938_white_spotting1.32494102
52MP0004084_abnormal_cardiac_muscle1.29171841
53MP0004142_abnormal_muscle_tone1.27251274
54MP0001730_embryonic_growth_arrest1.22227666
55MP0005253_abnormal_eye_physiology1.19840316
56MP0000750_abnormal_muscle_regeneration1.18787374
57MP0005408_hypopigmentation1.18135332
58MP0000358_abnormal_cell_content/1.13952429
59MP0002736_abnormal_nociception_after1.11910554
60MP0002272_abnormal_nervous_system1.11484151
61MP0003567_abnormal_fetal_cardiomyocyte1.11124020
62MP0005551_abnormal_eye_electrophysiolog1.10485136
63MP0000762_abnormal_tongue_morphology1.06624796
64MP0000647_abnormal_sebaceous_gland1.06576005
65MP0005389_reproductive_system_phenotype1.05630143
66MP0009745_abnormal_behavioral_response1.03917127
67MP0000350_abnormal_cell_proliferation1.02126408
68MP0002277_abnormal_respiratory_mucosa1.01607180
69MP0003119_abnormal_digestive_system1.00847174
70MP0002127_abnormal_cardiovascular_syste0.99919883
71MP0001697_abnormal_embryo_size0.99081041
72MP0004145_abnormal_muscle_electrophysio0.98314085
73MP0006072_abnormal_retinal_apoptosis0.95390937
74MP0001929_abnormal_gametogenesis0.94519352
75MP0005266_abnormal_metabolism0.94399496
76MP0002210_abnormal_sex_determination0.92972511
77MP0005379_endocrine/exocrine_gland_phen0.92421738
78MP0004147_increased_porphyrin_level0.92397389
79MP0001764_abnormal_homeostasis0.92391822
80MP0002234_abnormal_pharynx_morphology0.90975195
81MP0004215_abnormal_myocardial_fiber0.90588794
82MP0005410_abnormal_fertilization0.90575904
83MP0005367_renal/urinary_system_phenotyp0.90526244
84MP0000516_abnormal_urinary_system0.90526244
85MP0001970_abnormal_pain_threshold0.89135129
86MP0009697_abnormal_copulation0.89013480
87MP0000653_abnormal_sex_gland0.88747641
88MP0000631_abnormal_neuroendocrine_gland0.86675810
89MP0002332_abnormal_exercise_endurance0.85515867
90MP0009250_abnormal_appendicular_skeleto0.84716174
91MP0003137_abnormal_impulse_conducting0.84596402
92MP0002095_abnormal_skin_pigmentation0.84064136
93MP0002085_abnormal_embryonic_tissue0.83527967
94MP0001486_abnormal_startle_reflex0.82972825
95MP0002102_abnormal_ear_morphology0.82803400
96MP0001986_abnormal_taste_sensitivity0.82231039
97MP0000751_myopathy0.81677629
98MP0010386_abnormal_urinary_bladder0.81479214
99MP0002733_abnormal_thermal_nociception0.81122508
100MP0001919_abnormal_reproductive_system0.79546678
101MP0002734_abnormal_mechanical_nocicepti0.79042708
102MP0000537_abnormal_urethra_morphology0.78818375
103MP0001968_abnormal_touch/_nociception0.78257388
104MP0002080_prenatal_lethality0.76567889
105MP0005380_embryogenesis_phenotype0.76044278
106MP0001672_abnormal_embryogenesis/_devel0.76044278
107MP0001145_abnormal_male_reproductive0.75134355
108MP0000313_abnormal_cell_death0.74980665
109MP0003880_abnormal_central_pattern0.74955443
110MP0001485_abnormal_pinna_reflex0.73321662
111MP0004036_abnormal_muscle_relaxation0.73259720
112MP0005330_cardiomyopathy0.73253622
113MP0009053_abnormal_anal_canal0.73186957
114MP0002572_abnormal_emotion/affect_behav0.72735380
115MP0001293_anophthalmia0.72429102
116MP0005187_abnormal_penis_morphology0.72191671
117MP0001542_abnormal_bone_strength0.71800032
118MP0003937_abnormal_limbs/digits/tail_de0.71747695
119MP0003938_abnormal_ear_development0.71724981
120MP0002557_abnormal_social/conspecific_i0.70225728
121MP0005646_abnormal_pituitary_gland0.70173832
122MP0002090_abnormal_vision0.69892133
123* MP0000778_abnormal_nervous_system0.69809353
124MP0003011_delayed_dark_adaptation0.69622630
125MP0003755_abnormal_palate_morphology0.69272862
126MP0001286_abnormal_eye_development0.69108597
127MP0001727_abnormal_embryo_implantation0.68920695
128MP0002282_abnormal_trachea_morphology0.68479686
129MP0003942_abnormal_urinary_system0.66679826
130MP0002233_abnormal_nose_morphology0.66618093
131MP0003890_abnormal_embryonic-extraembry0.66239660

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.57559525
2Abnormal mitochondria in muscle tissue (HP:0008316)5.94070500
3Mitochondrial inheritance (HP:0001427)5.81183883
4Progressive macrocephaly (HP:0004481)5.39499298
5Acute encephalopathy (HP:0006846)5.16014792
6Hepatocellular necrosis (HP:0001404)5.08438215
7Increased CSF lactate (HP:0002490)5.07799689
8Increased hepatocellular lipid droplets (HP:0006565)4.53000375
9Abnormality of cells of the erythroid lineage (HP:0012130)4.52820730
10Hepatic necrosis (HP:0002605)4.37332327
11Reticulocytopenia (HP:0001896)4.35191448
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.02191711
13Lipid accumulation in hepatocytes (HP:0006561)3.96270921
14Abnormal number of erythroid precursors (HP:0012131)3.93980259
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.85275385
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.85275385
17Exercise intolerance (HP:0003546)3.76137804
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.59168897
19Renal Fanconi syndrome (HP:0001994)3.58104971
20Respiratory failure (HP:0002878)3.55694269
21Cerebral edema (HP:0002181)3.55685040
22Abnormality of glycolysis (HP:0004366)3.54623556
23Increased serum pyruvate (HP:0003542)3.54623556
24Increased serum lactate (HP:0002151)3.47249169
25Macrocytic anemia (HP:0001972)3.45161543
263-Methylglutaconic aciduria (HP:0003535)3.25149398
27Aplasia/Hypoplasia of the sacrum (HP:0008517)3.22485593
28Lactic acidosis (HP:0003128)3.17516953
29Optic disc pallor (HP:0000543)3.13394627
30Increased intramyocellular lipid droplets (HP:0012240)3.11995010
31Exertional dyspnea (HP:0002875)3.07964502
32Leukodystrophy (HP:0002415)2.97895588
33Pallor (HP:0000980)2.86539290
34Breast hypoplasia (HP:0003187)2.86480206
35Respiratory difficulties (HP:0002880)2.76723540
36Oral leukoplakia (HP:0002745)2.73389085
37Cerebral hypomyelination (HP:0006808)2.72362585
38Methylmalonic aciduria (HP:0012120)2.55130626
39Abnormal hemoglobin (HP:0011902)2.54983997
40Increased muscle lipid content (HP:0009058)2.50867245
41Emotional lability (HP:0000712)2.48357347
42Birth length less than 3rd percentile (HP:0003561)2.46745287
43CNS demyelination (HP:0007305)2.44771482
44Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.43376408
45Molar tooth sign on MRI (HP:0002419)2.38495576
46Abnormality of midbrain morphology (HP:0002418)2.38495576
47Abnormality of renal resorption (HP:0011038)2.37950032
48Methylmalonic acidemia (HP:0002912)2.34856856
49Abnormality of alanine metabolism (HP:0010916)2.32048308
50Hyperalaninemia (HP:0003348)2.32048308
51Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32048308
52Rough bone trabeculation (HP:0100670)2.29711174
53Aplastic anemia (HP:0001915)2.27522590
54Pancreatic fibrosis (HP:0100732)2.26550659
55Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.23442918
56Abnormal protein N-linked glycosylation (HP:0012347)2.23442918
57Abnormal protein glycosylation (HP:0012346)2.23442918
58Abnormal glycosylation (HP:0012345)2.23442918
59Carpal bone hypoplasia (HP:0001498)2.21814768
60Trismus (HP:0000211)2.19551465
61Microvesicular hepatic steatosis (HP:0001414)2.18602416
62Myokymia (HP:0002411)2.17849354
63Absent thumb (HP:0009777)2.14112094
64Abnormality of placental membranes (HP:0011409)2.12420905
65Amniotic constriction ring (HP:0009775)2.12420905
66Stenosis of the external auditory canal (HP:0000402)2.07214514
67Hyperphosphaturia (HP:0003109)2.06479071
68Congenital, generalized hypertrichosis (HP:0004540)2.06460604
69True hermaphroditism (HP:0010459)2.04830150
70Aplasia/hypoplasia of the uterus (HP:0008684)2.03644110
71Gait imbalance (HP:0002141)2.00180972
72Generalized aminoaciduria (HP:0002909)1.97542675
73Nephrogenic diabetes insipidus (HP:0009806)1.97178399
74Congenital ichthyosiform erythroderma (HP:0007431)1.94004546
75Short tibia (HP:0005736)1.93852913
76Lethargy (HP:0001254)1.91453604
77Patellar aplasia (HP:0006443)1.90275298
78Secondary amenorrhea (HP:0000869)1.90257366
79Aplasia/Hypoplasia of the patella (HP:0006498)1.90102802
80Horseshoe kidney (HP:0000085)1.89233560
81X-linked dominant inheritance (HP:0001423)1.88115990
82Triphalangeal thumb (HP:0001199)1.85960278
83CNS hypomyelination (HP:0003429)1.84436706
84Hyperglycinemia (HP:0002154)1.83406919
85Medial flaring of the eyebrow (HP:0010747)1.83392773
86Type I transferrin isoform profile (HP:0003642)1.83341631
87Pancytopenia (HP:0001876)1.81975477
88Absent radius (HP:0003974)1.80889386
89Abnormal trabecular bone morphology (HP:0100671)1.80640396
90Abnormality of urine glucose concentration (HP:0011016)1.79171533
91Glycosuria (HP:0003076)1.79171533
92Limb dystonia (HP:0002451)1.78834098
93Concave nail (HP:0001598)1.78726304
94Abnormality of the anterior horn cell (HP:0006802)1.78459394
95Degeneration of anterior horn cells (HP:0002398)1.78459394
96Median cleft lip (HP:0000161)1.77606000
97Premature ovarian failure (HP:0008209)1.76163436
98Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.75228248
99Unsteady gait (HP:0002317)1.75153819
100Microretrognathia (HP:0000308)1.75086234
101Atrophy/Degeneration involving motor neurons (HP:0007373)1.73529555
102Abnormality of dicarboxylic acid metabolism (HP:0010995)1.72851123
103Dicarboxylic aciduria (HP:0003215)1.72851123
104Parakeratosis (HP:0001036)1.71503413
105Aplasia involving forearm bones (HP:0009822)1.71434369
106Absent forearm bone (HP:0003953)1.71434369
107Pancreatic cysts (HP:0001737)1.71260372
108Abnormal lung lobation (HP:0002101)1.70866645
109Aplasia/Hypoplasia involving the musculature (HP:0001460)1.70385027
110Abnormality of serum amino acid levels (HP:0003112)1.69140840
111Abnormality of the labia minora (HP:0012880)1.68960063
112Poor suck (HP:0002033)1.68526543
113Blindness (HP:0000618)1.66184702
114Abnormal urine phosphate concentration (HP:0012599)1.66068642
115Sparse eyelashes (HP:0000653)1.64988930
116Progressive microcephaly (HP:0000253)1.64922079
117Progressive external ophthalmoplegia (HP:0000590)1.64556836
118Multiple enchondromatosis (HP:0005701)1.64252016
119Type 2 muscle fiber atrophy (HP:0003554)1.64057971
120Abnormality of methionine metabolism (HP:0010901)1.63935262
121Aplasia/Hypoplasia of the tibia (HP:0005772)1.63670737
122Opisthotonus (HP:0002179)1.63484619
123Reduced antithrombin III activity (HP:0001976)1.63253859
124Neuroendocrine neoplasm (HP:0100634)1.61434781
125Colon cancer (HP:0003003)1.60771206
126Retinal dysplasia (HP:0007973)1.60401382
127Congenital primary aphakia (HP:0007707)1.60348149
128Facial cleft (HP:0002006)1.59113717
129Meckel diverticulum (HP:0002245)1.57658223
130Supernumerary spleens (HP:0009799)1.56210387
131Adrenal hypoplasia (HP:0000835)1.55823851
13211 pairs of ribs (HP:0000878)1.55595213
133Premature graying of hair (HP:0002216)1.55594381
134Abnormality of the preputium (HP:0100587)1.55546770
135Rectal fistula (HP:0100590)1.55521620
136Rectovaginal fistula (HP:0000143)1.55521620
137Sclerocornea (HP:0000647)1.55107791
138Depressed nasal ridge (HP:0000457)1.54795282

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.18553112
2BUB13.76575923
3TLK13.63483968
4NME23.24340491
5NME13.09087801
6STK162.97935539
7EIF2AK12.95673994
8WEE12.65982036
9SRPK12.59478351
10LIMK12.26368720
11CASK2.19239668
12TRIM282.13875599
13PBK2.00101541
14VRK11.93023413
15TESK21.88452363
16TSSK61.87337779
17TESK11.86448627
18PLK41.85874828
19NUAK11.83990566
20MAP4K21.80730360
21EIF2AK31.71975453
22MAP3K121.70865416
23BRAF1.70739245
24ZAK1.64178037
25OBSCN1.58228184
26STK38L1.56374787
27MYLK1.54690988
28MST41.50420265
29EPHA21.49918031
30CDC71.49658491
31AURKA1.47336839
32CSNK1G31.44545574
33PIM21.41909359
34AKT31.40079458
35NEK11.39482015
36CDK191.39011193
37MAP2K71.34346705
38MAP3K41.31031479
39PLK11.30068723
40CSNK1G21.27468445
41MKNK11.23049014
42PNCK1.21401850
43CSNK1G11.21317166
44PLK31.16966791
45BCR1.16141410
46DYRK21.14691064
47MKNK21.14440199
48CDK81.13823807
49ARAF1.13341724
50RPS6KB21.12797476
51AURKB1.06458082
52TTK1.04422674
53CSNK1A1L1.02185299
54DAPK30.99895608
55PDK30.99870891
56PDK40.99870891
57MAP3K110.94549971
58PHKG20.94300818
59PHKG10.94300818
60MINK10.92872038
61ACVR1B0.89614670
62PRKCI0.86634939
63MARK10.86449327
64DAPK10.85322802
65ILK0.84259639
66PLK20.83149874
67CSNK2A10.81706866
68BRSK20.80922146
69BMPR1B0.80018931
70CSNK2A20.79080600
71PASK0.76890075
72ADRBK20.75941723
73CDK70.75039895
74CHEK20.72595288
75PAK10.68809471
76PRKCG0.68782567
77EPHA40.68132394
78PDK20.67548189
79STK240.66914202
80ERBB30.66800277
81GRK70.65809525
82LATS20.65347536
83CCNB10.64456504
84BCKDK0.64426887
85TIE10.62999884
86MAPK130.62702267
87BMPR20.62485087
88ERBB40.62056352
89GRK10.61665487
90ABL20.61229231
91GRK50.60122686
92SCYL20.59739921
93MAPKAPK30.58434595
94DYRK30.58155740
95TAF10.57309167
96YES10.56258629
97PAK30.55002422
98BRSK10.53677700
99ADRBK10.52217300
100CDK140.51215422
101CDK11A0.49085504
102OXSR10.49070413
103TNIK0.48864410
104PAK40.48327320
105CDK180.46246985
106RPS6KA50.45061208
107PRKCE0.44943708
108PKN10.44856905
109ATR0.44852017
110EPHB20.44021193
111EIF2AK20.43974814
112KDR0.43124960
113MUSK0.42742030
114CDK150.41998197
115WNK40.41190752
116LMTK20.40544073
117IRAK30.40520798
118CDK30.39955828
119MAP2K20.38123873
120MAP2K60.37436802
121CAMK2A0.37369777
122WNK30.34337684
123PINK10.33721927
124PIK3CA0.33371053
125CHEK10.31973849
126CAMK2D0.31933637
127STK390.31848973
128ROCK20.31779989
129CAMK2G0.29472557
130CSNK1E0.29263295

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.33399724
2Oxidative phosphorylation_Homo sapiens_hsa001904.72824688
3Proteasome_Homo sapiens_hsa030504.64526764
4Parkinsons disease_Homo sapiens_hsa050124.16120594
5RNA polymerase_Homo sapiens_hsa030203.60606898
6Huntingtons disease_Homo sapiens_hsa050163.24935602
7Alzheimers disease_Homo sapiens_hsa050102.86650878
8DNA replication_Homo sapiens_hsa030302.83475591
9Mismatch repair_Homo sapiens_hsa034302.79133080
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.53342101
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.39194389
12Spliceosome_Homo sapiens_hsa030402.37881650
13Protein export_Homo sapiens_hsa030602.33279094
14Nucleotide excision repair_Homo sapiens_hsa034202.28024596
15Pyrimidine metabolism_Homo sapiens_hsa002402.26382634
16Homologous recombination_Homo sapiens_hsa034402.12467681
17Cardiac muscle contraction_Homo sapiens_hsa042601.97689765
18RNA transport_Homo sapiens_hsa030131.90413049
19Basal transcription factors_Homo sapiens_hsa030221.72436439
20Base excision repair_Homo sapiens_hsa034101.64617739
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.49913646
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.48718242
23RNA degradation_Homo sapiens_hsa030181.35180481
24Purine metabolism_Homo sapiens_hsa002301.29732539
25Fanconi anemia pathway_Homo sapiens_hsa034601.29141639
26Non-homologous end-joining_Homo sapiens_hsa034501.26352979
27One carbon pool by folate_Homo sapiens_hsa006701.25084151
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13613434
29Cell cycle_Homo sapiens_hsa041101.13413174
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09482515
31Collecting duct acid secretion_Homo sapiens_hsa049661.05710766
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01409664
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99674277
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.90822327
35Glutathione metabolism_Homo sapiens_hsa004800.90102138
36Vibrio cholerae infection_Homo sapiens_hsa051100.84127443
37Sulfur relay system_Homo sapiens_hsa041220.79864173
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77507186
39Butanoate metabolism_Homo sapiens_hsa006500.74774733
40Epstein-Barr virus infection_Homo sapiens_hsa051690.74249730
41Folate biosynthesis_Homo sapiens_hsa007900.72580626
42Metabolic pathways_Homo sapiens_hsa011000.71196278
43Pyruvate metabolism_Homo sapiens_hsa006200.70727803
44Carbon metabolism_Homo sapiens_hsa012000.70210581
45Arachidonic acid metabolism_Homo sapiens_hsa005900.68784273
46mRNA surveillance pathway_Homo sapiens_hsa030150.68761912
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68477265
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68227064
49Peroxisome_Homo sapiens_hsa041460.67754317
50Selenocompound metabolism_Homo sapiens_hsa004500.67720582
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63391154
52Fructose and mannose metabolism_Homo sapiens_hsa000510.61908209
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.61124432
54p53 signaling pathway_Homo sapiens_hsa041150.60022175
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.58555236
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57010960
57beta-Alanine metabolism_Homo sapiens_hsa004100.52866758
58Systemic lupus erythematosus_Homo sapiens_hsa053220.51196255
59Biosynthesis of amino acids_Homo sapiens_hsa012300.49238761
60Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46678738
61N-Glycan biosynthesis_Homo sapiens_hsa005100.46399317
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.44106148
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43986518
64Fatty acid metabolism_Homo sapiens_hsa012120.43265313
65Phenylalanine metabolism_Homo sapiens_hsa003600.42716095
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42698822
67Pentose phosphate pathway_Homo sapiens_hsa000300.40574666
68Oocyte meiosis_Homo sapiens_hsa041140.39187401
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.39173436
70Sulfur metabolism_Homo sapiens_hsa009200.37691177
71Galactose metabolism_Homo sapiens_hsa000520.37343289
72Tryptophan metabolism_Homo sapiens_hsa003800.36507004
73Tyrosine metabolism_Homo sapiens_hsa003500.35978907
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35313901
75Nicotine addiction_Homo sapiens_hsa050330.34552074
76Fatty acid elongation_Homo sapiens_hsa000620.34495850
77Linoleic acid metabolism_Homo sapiens_hsa005910.33420030
78Synaptic vesicle cycle_Homo sapiens_hsa047210.33059069
79Arginine and proline metabolism_Homo sapiens_hsa003300.31058147
80Vitamin B6 metabolism_Homo sapiens_hsa007500.28626615
81Alcoholism_Homo sapiens_hsa050340.28496304
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27317236
83Rheumatoid arthritis_Homo sapiens_hsa053230.26985280
84Chemical carcinogenesis_Homo sapiens_hsa052040.26855159
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26519150
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25941793
87Phagosome_Homo sapiens_hsa041450.25466068
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.24527371
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.23506005
90Tight junction_Homo sapiens_hsa045300.23359729
91Fatty acid degradation_Homo sapiens_hsa000710.22719477
92Phototransduction_Homo sapiens_hsa047440.21487509
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.21431150
94Hedgehog signaling pathway_Homo sapiens_hsa043400.20822549
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20135443
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20101388
97Drug metabolism - other enzymes_Homo sapiens_hsa009830.19861018
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.18213713
99Basal cell carcinoma_Homo sapiens_hsa052170.17329262
100Sphingolipid metabolism_Homo sapiens_hsa006000.16202042
101GABAergic synapse_Homo sapiens_hsa047270.14977311
102Propanoate metabolism_Homo sapiens_hsa006400.14818986
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.14268266
104Thyroid cancer_Homo sapiens_hsa052160.13909125
105Melanoma_Homo sapiens_hsa052180.12438903
106Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.11742678
107Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.11381860
108Hippo signaling pathway_Homo sapiens_hsa043900.11211207
109Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.10503893
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.10125704
111Steroid biosynthesis_Homo sapiens_hsa001000.09799879
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.09396635
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.09057179
114Ether lipid metabolism_Homo sapiens_hsa005650.08787541
115Nitrogen metabolism_Homo sapiens_hsa009100.08513076
116Bladder cancer_Homo sapiens_hsa052190.08320873
117Regulation of autophagy_Homo sapiens_hsa041400.08235958
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.07802404
119Graft-versus-host disease_Homo sapiens_hsa053320.07697127
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.07582144
121Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.06021093
122Serotonergic synapse_Homo sapiens_hsa047260.05639687
123Viral carcinogenesis_Homo sapiens_hsa052030.05441463
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.05126474

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