PFDN4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)5.22056783
2establishment of protein localization to mitochondrial membrane (GO:0090151)4.65220419
3proteasome assembly (GO:0043248)4.55104350
4protein neddylation (GO:0045116)4.52881861
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.51795867
6energy coupled proton transport, down electrochemical gradient (GO:0015985)4.25333303
7ATP synthesis coupled proton transport (GO:0015986)4.25333303
8establishment of integrated proviral latency (GO:0075713)4.23314165
9protein deneddylation (GO:0000338)4.14359447
107-methylguanosine mRNA capping (GO:0006370)4.02194327
11CENP-A containing nucleosome assembly (GO:0034080)4.00208982
127-methylguanosine RNA capping (GO:0009452)3.96561923
13RNA capping (GO:0036260)3.96561923
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.92662381
15cullin deneddylation (GO:0010388)3.90237551
16negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.89863625
17chromatin remodeling at centromere (GO:0031055)3.84505358
18anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.83603444
19mitotic metaphase plate congression (GO:0007080)3.81463640
20ribosomal small subunit biogenesis (GO:0042274)3.76094190
21positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.72645179
22viral life cycle (GO:0019058)3.68978130
23regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.68709917
24maturation of SSU-rRNA (GO:0030490)3.66645520
25maturation of 5.8S rRNA (GO:0000460)3.60827700
26transcription elongation from RNA polymerase III promoter (GO:0006385)3.58359710
27termination of RNA polymerase III transcription (GO:0006386)3.58359710
28negative regulation of ligase activity (GO:0051352)3.57788729
29negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.57788729
30mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.53930478
31protein K6-linked ubiquitination (GO:0085020)3.53681747
32establishment of viral latency (GO:0019043)3.51354940
33nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.50650885
34exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.47179030
35attachment of spindle microtubules to kinetochore (GO:0008608)3.41200802
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.40113130
37mitochondrial respiratory chain complex I assembly (GO:0032981)3.40113130
38NADH dehydrogenase complex assembly (GO:0010257)3.40113130
39ribosomal large subunit biogenesis (GO:0042273)3.38343245
40kinetochore assembly (GO:0051382)3.36703255
41protein-cofactor linkage (GO:0018065)3.36579580
42DNA replication-independent nucleosome organization (GO:0034724)3.36282301
43DNA replication-independent nucleosome assembly (GO:0006336)3.36282301
44kinetochore organization (GO:0051383)3.35312354
45viral transcription (GO:0019083)3.34520837
46regulation of cellular amino acid metabolic process (GO:0006521)3.34403393
47translational termination (GO:0006415)3.33002724
48transcription elongation from RNA polymerase I promoter (GO:0006362)3.32574855
49protein complex biogenesis (GO:0070271)3.30439781
50spliceosomal complex assembly (GO:0000245)3.29802028
51histone exchange (GO:0043486)3.28944409
52rRNA methylation (GO:0031167)3.28790319
53positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.26808584
54DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.26458385
55metaphase plate congression (GO:0051310)3.25015659
56protein complex disassembly (GO:0043241)3.23827257
57organelle disassembly (GO:1903008)3.23022797
58nuclear-transcribed mRNA catabolic process (GO:0000956)3.21965356
59DNA replication checkpoint (GO:0000076)3.20813603
60macromolecular complex disassembly (GO:0032984)3.20460739
61establishment of chromosome localization (GO:0051303)3.20129072
62transcription-coupled nucleotide-excision repair (GO:0006283)3.19796364
63respiratory chain complex IV assembly (GO:0008535)3.18404278
64signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.18340089
65intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.18340089
66cellular component biogenesis (GO:0044085)3.17733908
67ATP biosynthetic process (GO:0006754)3.17689436
68signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.15597057
69signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.15597057
70signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.15597057
71cotranslational protein targeting to membrane (GO:0006613)3.14708126
72positive regulation of ligase activity (GO:0051351)3.12198712
73rRNA modification (GO:0000154)3.12003317
74hydrogen ion transmembrane transport (GO:1902600)3.11567534
75respiratory electron transport chain (GO:0022904)3.11132855
76mitochondrial respiratory chain complex assembly (GO:0033108)3.11038608
77transcription elongation from RNA polymerase II promoter (GO:0006368)3.10821435
78cytochrome complex assembly (GO:0017004)3.10587329
79SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.10156628
80DNA double-strand break processing (GO:0000729)3.10061596
81establishment of protein localization to mitochondrion (GO:0072655)3.10006641
82signal transduction involved in DNA damage checkpoint (GO:0072422)3.08626998
83signal transduction involved in DNA integrity checkpoint (GO:0072401)3.08626998
84pseudouridine synthesis (GO:0001522)3.08308583
85spliceosomal snRNP assembly (GO:0000387)3.08258999
86DNA damage response, detection of DNA damage (GO:0042769)3.08243706
87microtubule depolymerization (GO:0007019)3.07947832
88signal transduction involved in cell cycle checkpoint (GO:0072395)3.07020767
89protein targeting to ER (GO:0045047)3.06879436
90histone mRNA metabolic process (GO:0008334)3.05341427
91translational initiation (GO:0006413)3.04838510
92electron transport chain (GO:0022900)3.04281948
93oxidative phosphorylation (GO:0006119)3.04045694
94mRNA catabolic process (GO:0006402)3.03768962
95regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.03739401
96regulation of mitotic spindle checkpoint (GO:1903504)3.03739401
97tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.03032933
98RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.03032933
99purine nucleoside triphosphate biosynthetic process (GO:0009145)3.02615653
100protein targeting to membrane (GO:0006612)3.01818515
101protein targeting to mitochondrion (GO:0006626)3.01615207
102purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.00526996
103pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.00250928
104termination of RNA polymerase I transcription (GO:0006363)3.00209667
105translation (GO:0006412)2.99871256
106GTP biosynthetic process (GO:0006183)2.99715776
107ribosome assembly (GO:0042255)2.99235731
108L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.98554517
109pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.98518616
110inner mitochondrial membrane organization (GO:0007007)2.97734049
111ribosomal small subunit assembly (GO:0000028)2.94221482
112regulation of ubiquitin-protein transferase activity (GO:0051438)2.92922885
113protein K11-linked ubiquitination (GO:0070979)2.92789200
114ribonucleoside triphosphate biosynthetic process (GO:0009201)2.92508883
115protein localization to endoplasmic reticulum (GO:0070972)2.92478631
116establishment of protein localization to endoplasmic reticulum (GO:0072599)2.91615511
117translational elongation (GO:0006414)2.91266791
118rRNA metabolic process (GO:0016072)2.89379114
119protein localization to mitochondrion (GO:0070585)2.89267412
120DNA-templated transcription, elongation (GO:0006354)2.88937903
121regulation of mitochondrial translation (GO:0070129)2.88758655
122rRNA processing (GO:0006364)2.87947461
123transcription from RNA polymerase I promoter (GO:0006360)2.87377544
124regulation of helicase activity (GO:0051095)2.87010626
125antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.86651672
126water-soluble vitamin biosynthetic process (GO:0042364)2.85613856
127cellular protein complex disassembly (GO:0043624)2.85323022
128ribonucleoprotein complex biogenesis (GO:0022613)2.84404497
129DNA replication initiation (GO:0006270)2.84074645
130regulation of ligase activity (GO:0051340)2.82116659
131spindle checkpoint (GO:0031577)2.79641791

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.70622484
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.23057510
3E2F7_22180533_ChIP-Seq_HELA_Human4.18466387
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.92094015
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.71296224
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.39572198
7ETS1_20019798_ChIP-Seq_JURKAT_Human3.20782443
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.14907247
9CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.13780583
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.98629762
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.92685858
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.92191499
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.91208811
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.70353807
15* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.60035540
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.57256507
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.46919101
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.43297526
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.42385903
20VDR_23849224_ChIP-Seq_CD4+_Human2.42343959
21ELK1_19687146_ChIP-ChIP_HELA_Human2.37100919
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.35311803
23* MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.33238895
24DCP1A_22483619_ChIP-Seq_HELA_Human2.20426759
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.16732910
26FOXM1_23109430_ChIP-Seq_U2OS_Human2.12849029
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.03365516
28XRN2_22483619_ChIP-Seq_HELA_Human2.02413432
29TTF2_22483619_ChIP-Seq_HELA_Human2.02350842
30THAP11_20581084_ChIP-Seq_MESCs_Mouse2.00592996
31E2F1_18555785_ChIP-Seq_MESCs_Mouse2.00077677
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.88548007
33* FOXP3_21729870_ChIP-Seq_TREG_Human1.86262989
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.85996400
35GABP_19822575_ChIP-Seq_HepG2_Human1.82176905
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.76742335
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.76530937
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.74828051
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71076960
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.70432250
41MYC_18940864_ChIP-ChIP_HL60_Human1.70355288
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.69011813
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67542574
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66014127
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.61506456
46* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60872352
47FUS_26573619_Chip-Seq_HEK293_Human1.57881457
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.55828287
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.53077388
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45183026
51AR_21909140_ChIP-Seq_LNCAP_Human1.44374849
52ELK1_22589737_ChIP-Seq_MCF10A_Human1.40478163
53KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.39123069
54EWS_26573619_Chip-Seq_HEK293_Human1.38916199
55VDR_22108803_ChIP-Seq_LS180_Human1.38374082
56NANOG_16153702_ChIP-ChIP_HESCs_Human1.37445433
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37406967
58ZNF274_21170338_ChIP-Seq_K562_Hela1.35420766
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.34974864
60* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31915921
61PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31173610
62FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29438404
63ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.27590971
64ESR1_15608294_ChIP-ChIP_MCF-7_Human1.25925807
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24473555
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.24265203
67POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22607454
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.22209917
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.22054583
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.19857366
71HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17774502
72IRF1_19129219_ChIP-ChIP_H3396_Human1.16881513
73EZH2_22144423_ChIP-Seq_EOC_Human1.15949865
74SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.12481883
75TAF15_26573619_Chip-Seq_HEK293_Human1.09671278
76TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09017796
77FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08913493
78ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08176489
79TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07905699
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02988289
81CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02174910
82POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01778588
83P300_19829295_ChIP-Seq_ESCs_Human0.99194889
84KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97270710
85RNF2_27304074_Chip-Seq_NSC_Mouse0.97267941
86SOX2_16153702_ChIP-ChIP_HESCs_Human0.94171945
87ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92946202
88KDM5A_27292631_Chip-Seq_BREAST_Human0.91829201
89DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91766392
90SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90935247
91* ER_23166858_ChIP-Seq_MCF-7_Human0.90407198
92SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89295803
93KAP1_22055183_ChIP-Seq_ESCs_Mouse0.89008058
94SOX17_20123909_ChIP-Seq_XEN_Mouse0.88639826
95IGF1R_20145208_ChIP-Seq_DFB_Human0.87783648
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87258974
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87182431
98CTBP1_25329375_ChIP-Seq_LNCAP_Human0.86177659
99TP53_22573176_ChIP-Seq_HFKS_Human0.85063518
100REST_19997604_ChIP-ChIP_NEURONS_Mouse0.84304590
101CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83897167
102BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82750443
103NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.81997546
104RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.81203578
105ERG_20887958_ChIP-Seq_HPC-7_Mouse0.80867172
106CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80337180
107CTBP2_25329375_ChIP-Seq_LNCAP_Human0.79245355
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.78782720
109CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.77291175
110* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76902924
111JUN_21703547_ChIP-Seq_K562_Human0.76384128
112POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.74091368
113NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.73723829
114EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.73374819
115ELF5_23300383_ChIP-Seq_T47D_Human0.72323142
116ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.70789172

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.14608526
2MP0003718_maternal_effect3.53357001
3MP0001529_abnormal_vocalization3.37048641
4MP0009379_abnormal_foot_pigmentation3.15809063
5MP0004957_abnormal_blastocyst_morpholog3.11720964
6MP0010094_abnormal_chromosome_stability2.95110592
7MP0003880_abnormal_central_pattern2.70304598
8MP0003077_abnormal_cell_cycle2.66669885
9MP0008932_abnormal_embryonic_tissue2.58924795
10MP0006276_abnormal_autonomic_nervous2.53651727
11MP0008877_abnormal_DNA_methylation2.53572124
12MP0003941_abnormal_skin_development2.43629752
13MP0001905_abnormal_dopamine_level2.43451088
14MP0006292_abnormal_olfactory_placode2.40657590
15MP0008058_abnormal_DNA_repair2.37404250
16MP0003111_abnormal_nucleus_morphology2.34175226
17MP0001293_anophthalmia2.21032223
18MP0001188_hyperpigmentation2.20509825
19MP0003123_paternal_imprinting2.10364651
20MP0002102_abnormal_ear_morphology2.07007694
21MP0003806_abnormal_nucleotide_metabolis2.03280060
22MP0008057_abnormal_DNA_replication2.01606457
23MP0003121_genomic_imprinting1.99574311
24MP0003186_abnormal_redox_activity1.78902158
25MP0003567_abnormal_fetal_cardiomyocyte1.67624122
26MP0003136_yellow_coat_color1.64408895
27MP0002638_abnormal_pupillary_reflex1.62662155
28MP0008789_abnormal_olfactory_epithelium1.61596814
29MP0003315_abnormal_perineum_morphology1.58701275
30MP0010386_abnormal_urinary_bladder1.54679321
31MP0006072_abnormal_retinal_apoptosis1.54636280
32MP0002653_abnormal_ependyma_morphology1.50667613
33MP0003786_premature_aging1.48434419
34MP0003787_abnormal_imprinting1.48099101
35MP0002736_abnormal_nociception_after1.44776902
36MP0008007_abnormal_cellular_replicative1.44010213
37MP0002163_abnormal_gland_morphology1.43581133
38MP0001986_abnormal_taste_sensitivity1.43386594
39MP0008260_abnormal_autophagy1.41222975
40MP0002734_abnormal_mechanical_nocicepti1.36953595
41MP0002751_abnormal_autonomic_nervous1.36327052
42MP0006035_abnormal_mitochondrial_morpho1.34479126
43MP0000372_irregular_coat_pigmentation1.33707581
44MP0004142_abnormal_muscle_tone1.32378526
45MP0008995_early_reproductive_senescence1.32274031
46MP0002210_abnormal_sex_determination1.32096551
47MP0003011_delayed_dark_adaptation1.30864754
48MP0001984_abnormal_olfaction1.30565922
49MP0005408_hypopigmentation1.29496463
50MP0001968_abnormal_touch/_nociception1.27824849
51MP0000778_abnormal_nervous_system1.26897711
52MP0002184_abnormal_innervation1.26689484
53MP0001286_abnormal_eye_development1.26329853
54MP0002938_white_spotting1.24036693
55MP0005395_other_phenotype1.22482930
56MP0005499_abnormal_olfactory_system1.22384682
57MP0005394_taste/olfaction_phenotype1.22384682
58MP0005423_abnormal_somatic_nervous1.22080590
59MP0001730_embryonic_growth_arrest1.21893115
60MP0003890_abnormal_embryonic-extraembry1.21567411
61MP0000350_abnormal_cell_proliferation1.18222815
62MP0002837_dystrophic_cardiac_calcinosis1.17424121
63MP0002735_abnormal_chemical_nociception1.17211331
64MP0001929_abnormal_gametogenesis1.17190454
65MP0000653_abnormal_sex_gland1.15848804
66MP0003937_abnormal_limbs/digits/tail_de1.15543331
67MP0001119_abnormal_female_reproductive1.14803769
68MP0002160_abnormal_reproductive_system1.14243029
69MP0005389_reproductive_system_phenotype1.11587316
70MP0005084_abnormal_gallbladder_morpholo1.09993122
71MP0003122_maternal_imprinting1.05128099
72MP0004133_heterotaxia1.04588191
73MP0002233_abnormal_nose_morphology1.04458003
74MP0001727_abnormal_embryo_implantation1.03883503
75MP0003119_abnormal_digestive_system1.03033575
76MP0005253_abnormal_eye_physiology1.02785952
77MP0001440_abnormal_grooming_behavior1.02216180
78MP0004270_analgesia1.01748625
79MP0001919_abnormal_reproductive_system0.99525311
80MP0000631_abnormal_neuroendocrine_gland0.99365497
81MP0002733_abnormal_thermal_nociception0.98394656
82MP0009046_muscle_twitch0.97751890
83MP0001970_abnormal_pain_threshold0.96919183
84MP0005551_abnormal_eye_electrophysiolog0.96694864
85MP0001145_abnormal_male_reproductive0.96465599
86MP0002234_abnormal_pharynx_morphology0.93880773
87MP0005386_behavior/neurological_phenoty0.93473811
88MP0004924_abnormal_behavior0.93473811
89MP0002085_abnormal_embryonic_tissue0.93147706
90MP0001485_abnormal_pinna_reflex0.93109437
91MP0001697_abnormal_embryo_size0.92471390
92MP0002277_abnormal_respiratory_mucosa0.91882453
93MP0003646_muscle_fatigue0.91415625
94MP0002697_abnormal_eye_size0.90819894
95MP0008872_abnormal_physiological_respon0.90739402
96MP0002572_abnormal_emotion/affect_behav0.89234659
97MP0005646_abnormal_pituitary_gland0.88782552
98MP0003861_abnormal_nervous_system0.87761816
99MP0004147_increased_porphyrin_level0.87235782
100MP0002752_abnormal_somatic_nervous0.85672047
101MP0002272_abnormal_nervous_system0.85353112
102MP0005391_vision/eye_phenotype0.82406520
103MP0009745_abnormal_behavioral_response0.82114948
104MP0000049_abnormal_middle_ear0.80199800
105MP0005379_endocrine/exocrine_gland_phen0.80174132
106MP0000358_abnormal_cell_content/0.79504805
107MP0005451_abnormal_body_composition0.79424328
108MP0009697_abnormal_copulation0.79315353
109MP0003755_abnormal_palate_morphology0.78753848
110MP0003699_abnormal_female_reproductive0.78685048
111MP0000579_abnormal_nail_morphology0.78012523
112MP0010030_abnormal_orbit_morphology0.77575125
113MP0002111_abnormal_tail_morphology0.77540580
114MP0000566_synostosis0.77159958
115MP0005195_abnormal_posterior_eye0.76783036
116MP0002084_abnormal_developmental_patter0.75292185
117MP0002090_abnormal_vision0.74601146
118MP0000026_abnormal_inner_ear0.74550914
119MP0002161_abnormal_fertility/fecundity0.74334161
120MP0006036_abnormal_mitochondrial_physio0.73347305
121MP0002067_abnormal_sensory_capabilities0.72746595
122MP0005075_abnormal_melanosome_morpholog0.72659465
123MP0005409_darkened_coat_color0.72384347
124MP0003938_abnormal_ear_development0.71966545
125MP0003942_abnormal_urinary_system0.71689827
126MP0000313_abnormal_cell_death0.71369100
127MP0000538_abnormal_urinary_bladder0.71143025
128MP0002177_abnormal_outer_ear0.68560901

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.65648297
2Birth length less than 3rd percentile (HP:0003561)4.39730189
3Progressive macrocephaly (HP:0004481)3.96012485
4Abnormal mitochondria in muscle tissue (HP:0008316)3.95999809
5Mitochondrial inheritance (HP:0001427)3.95461422
6Increased hepatocellular lipid droplets (HP:0006565)3.83910055
7Breast hypoplasia (HP:0003187)3.53570785
8Acute encephalopathy (HP:0006846)3.45557837
9Increased CSF lactate (HP:0002490)3.40756899
10Increased serum pyruvate (HP:0003542)3.29338309
11Abnormality of glycolysis (HP:0004366)3.29338309
12Abnormality of the labia minora (HP:0012880)3.17554064
13Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.13041781
14Lipid accumulation in hepatocytes (HP:0006561)3.11683656
15Congenital, generalized hypertrichosis (HP:0004540)3.07315323
16Renal Fanconi syndrome (HP:0001994)3.06333298
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.96059286
18Hepatocellular necrosis (HP:0001404)2.94816656
193-Methylglutaconic aciduria (HP:0003535)2.88603886
20Cerebral hypomyelination (HP:0006808)2.84193547
21Exertional dyspnea (HP:0002875)2.82971020
22Septo-optic dysplasia (HP:0100842)2.82338705
23Abnormality of cells of the erythroid lineage (HP:0012130)2.81053154
24Decreased activity of mitochondrial respiratory chain (HP:0008972)2.78788053
25Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.78788053
26Patellar aplasia (HP:0006443)2.70896030
27Secondary amenorrhea (HP:0000869)2.68279778
28Carpal bone hypoplasia (HP:0001498)2.66175747
29Reticulocytopenia (HP:0001896)2.66034854
30Methylmalonic acidemia (HP:0002912)2.60400428
31Aplastic anemia (HP:0001915)2.55793813
32Medial flaring of the eyebrow (HP:0010747)2.55758085
33Aplasia/Hypoplasia of the patella (HP:0006498)2.54182173
34Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.45306024
35Abnormality of methionine metabolism (HP:0010901)2.44957821
36Irregular epiphyses (HP:0010582)2.41476494
37Supernumerary spleens (HP:0009799)2.41349146
38Adrenal hypoplasia (HP:0000835)2.40697841
39Gait imbalance (HP:0002141)2.39498269
40Exercise intolerance (HP:0003546)2.34513279
41Oral leukoplakia (HP:0002745)2.33396543
42Myokymia (HP:0002411)2.33242090
43Congenital primary aphakia (HP:0007707)2.33238563
44Increased serum lactate (HP:0002151)2.32997586
45Chromsome breakage (HP:0040012)2.32847755
46Optic disc pallor (HP:0000543)2.31098865
47Abnormal number of erythroid precursors (HP:0012131)2.29694300
48Leukodystrophy (HP:0002415)2.28592555
49Macrocytic anemia (HP:0001972)2.25486973
50Absent septum pellucidum (HP:0001331)2.24783518
51Lethargy (HP:0001254)2.24264915
52Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.23623866
53Abnormal hair whorl (HP:0010721)2.23385699
54Chromosomal breakage induced by crosslinking agents (HP:0003221)2.22584017
55Abnormality of the anterior horn cell (HP:0006802)2.22539630
56Degeneration of anterior horn cells (HP:0002398)2.22539630
57Respiratory difficulties (HP:0002880)2.22463843
58Parakeratosis (HP:0001036)2.21930917
59Increased intramyocellular lipid droplets (HP:0012240)2.21079674
60Aplasia/Hypoplasia of the sacrum (HP:0008517)2.20718016
61Premature ovarian failure (HP:0008209)2.19388290
62Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.18294317
63Abnormality of alanine metabolism (HP:0010916)2.18294317
64Hyperalaninemia (HP:0003348)2.18294317
65Hyperglycinemia (HP:0002154)2.16940746
66Respiratory failure (HP:0002878)2.14448506
67Increased muscle lipid content (HP:0009058)2.13767265
68Absent radius (HP:0003974)2.13730798
69Methylmalonic aciduria (HP:0012120)2.13669010
70Nephrogenic diabetes insipidus (HP:0009806)2.13398051
71Abnormality of serum amino acid levels (HP:0003112)2.13133871
72Abnormality of aspartate family amino acid metabolism (HP:0010899)2.10791167
73Amniotic constriction ring (HP:0009775)2.10610443
74Abnormality of placental membranes (HP:0011409)2.10610443
75Hepatic necrosis (HP:0002605)2.09727373
76Stenosis of the external auditory canal (HP:0000402)2.08593146
77Hypothermia (HP:0002045)2.06313190
78Rough bone trabeculation (HP:0100670)2.06302160
79Abnormality of the septum pellucidum (HP:0007375)2.06297838
80Pallor (HP:0000980)2.03252691
81Hyperphosphaturia (HP:0003109)2.02495960
82Horseshoe kidney (HP:0000085)2.02447210
83CNS hypomyelination (HP:0003429)2.00463529
84Meckel diverticulum (HP:0002245)2.00211147
85Pendular nystagmus (HP:0012043)1.99990881
86Aplasia involving forearm bones (HP:0009822)1.99416993
87Absent forearm bone (HP:0003953)1.99416993
88Neuroendocrine neoplasm (HP:0100634)1.99189066
89Fibular aplasia (HP:0002990)1.99033311
90Hypoplasia of the capital femoral epiphysis (HP:0003090)1.98214803
91Abnormality of urine glucose concentration (HP:0011016)1.97709589
92Glycosuria (HP:0003076)1.97709589
93Volvulus (HP:0002580)1.97295615
94Genital tract atresia (HP:0001827)1.95227596
95Abnormality of the preputium (HP:0100587)1.94514928
96Lactic acidosis (HP:0003128)1.93090301
97Pancreatic fibrosis (HP:0100732)1.92945543
98Pancreatic cysts (HP:0001737)1.91835303
99Type I transferrin isoform profile (HP:0003642)1.91267404
100X-linked dominant inheritance (HP:0001423)1.91254402
101Generalized aminoaciduria (HP:0002909)1.90650778
102Vaginal atresia (HP:0000148)1.89510289
103Abnormality of the ileum (HP:0001549)1.89054798
104Abnormality of renal resorption (HP:0011038)1.87877276
105Abnormal lung lobation (HP:0002101)1.87743582
106Duodenal stenosis (HP:0100867)1.87667011
107Small intestinal stenosis (HP:0012848)1.87667011
108Facial cleft (HP:0002006)1.86340503
109Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.84513138
110Bilateral microphthalmos (HP:0007633)1.84122977
111Megaloblastic anemia (HP:0001889)1.83709276
112True hermaphroditism (HP:0010459)1.83093658
113Absent thumb (HP:0009777)1.83056642
114Aplasia/Hypoplasia involving the musculature (HP:0001460)1.82999178
115CNS demyelination (HP:0007305)1.82599511
116Multiple enchondromatosis (HP:0005701)1.82261007
117Delusions (HP:0000746)1.81094710
118Aplasia/Hypoplasia of the uvula (HP:0010293)1.80904237
119Cerebral edema (HP:0002181)1.80790872
120Absent epiphyses (HP:0010577)1.78974746
121Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.78974746
122Molar tooth sign on MRI (HP:0002419)1.78245232
123Abnormality of midbrain morphology (HP:0002418)1.78245232
124Bifid tongue (HP:0010297)1.76836054
125Abnormality of chromosome stability (HP:0003220)1.75251095
126Optic nerve hypoplasia (HP:0000609)1.74853354
127Poor coordination (HP:0002370)1.74553488
128Abnormality of the duodenum (HP:0002246)1.74362365
129Cortical dysplasia (HP:0002539)1.74141797
130Abnormality of homocysteine metabolism (HP:0010919)1.73557931
131Homocystinuria (HP:0002156)1.73557931
132Hypoplasia of the pons (HP:0012110)1.73532686
133Anophthalmia (HP:0000528)1.73524136
134Triphalangeal thumb (HP:0001199)1.73145998
135Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72312973
136Limb dystonia (HP:0002451)1.71637366
137Facial hemangioma (HP:0000329)1.71295729
138Abnormal trabecular bone morphology (HP:0100671)1.70525156
139Colon cancer (HP:0003003)1.70109409
140Sclerocornea (HP:0000647)1.69129048
141Nephroblastoma (Wilms tumor) (HP:0002667)1.67734375
142Nephronophthisis (HP:0000090)1.66607937
143Abnormality of the pons (HP:0007361)1.66603055

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.12033088
2BUB13.55185257
3EIF2AK12.79827660
4PLK42.75525413
5SRPK12.63625805
6BMPR22.62291421
7ARAF2.55396635
8CDC72.44782246
9VRK12.39891541
10PNCK2.26595119
11NME12.19306791
12STK162.14055615
13BRAF2.11859768
14DYRK22.10653639
15MOS2.02339192
16WEE12.00274413
17TNIK1.99704572
18TAF11.98707001
19NUAK11.90912627
20EIF2AK31.88781797
21MAP2K71.84362846
22TRIM281.82181867
23CDK81.77938585
24TTK1.76246063
25CASK1.68832125
26NME21.68561211
27PBK1.63276625
28PLK31.61864388
29MAP3K121.61597414
30LATS21.57806343
31LIMK11.55925358
32MAPK131.52458710
33MKNK11.49322768
34PLK11.45133004
35BCR1.43813596
36STK38L1.41465003
37MAP3K41.37577280
38BMPR1B1.37240593
39MST41.26761266
40TSSK61.26683881
41MAP3K61.26531515
42AURKA1.25516713
43PLK21.24232715
44TESK21.22128282
45ACVR1B1.17024237
46MKNK21.16865261
47CHEK21.14714923
48CSNK1G31.13605813
49MAP4K21.09844520
50MARK11.05820795
51ERBB41.05055430
52TLK11.00893668
53MUSK0.99705386
54AURKB0.97274630
55MAP3K90.97258086
56BRSK20.89874677
57CSNK1G10.88756904
58ABL20.88694251
59TAOK30.84776016
60ILK0.81189707
61GRK10.79297748
62RAF10.78070248
63CSNK1G20.72503993
64GRK50.70578556
65DYRK30.67779239
66PIK3CA0.67309469
67EIF2AK20.65367675
68STK390.64990120
69CDK70.64012418
70KSR10.62678794
71PASK0.62653186
72CSNK1E0.62581591
73WNK30.60934617
74PRKCG0.60564237
75MAPKAPK30.59978087
76ALK0.59319238
77RPS6KA50.58274585
78CSNK2A10.58082411
79MINK10.57618630
80ADRBK20.57519763
81MAPKAPK50.57388773
82PAK10.57022708
83NTRK30.56112878
84OXSR10.55684517
85CCNB10.54135527
86ATR0.52397334
87NEK20.52175688
88MELK0.51928035
89UHMK10.51736262
90CSNK2A20.51237527
91CDK140.50863042
92CDK180.50743822
93CSNK1A1L0.50449303
94PAK40.50171723
95ERBB30.49618205
96INSRR0.49349407
97CHEK10.49307468
98BRSK10.49174582
99RPS6KA40.49001517
100ZAK0.48942206
101CDK190.48894661
102PIM20.48661407
103STK30.47469049
104GRK70.46765433
105ADRBK10.46720388
106CSNK1A10.46596413
107ATM0.45804184
108CDK150.45725302
109MAP3K80.43557719
110WNK40.42855780
111CDK11A0.42519905
112KSR20.42277294
113CAMK2B0.41798842
114PRKCI0.41288819
115SCYL20.41135311
116DYRK1A0.41119337
117CDK10.40437862
118FGFR10.40436896
119RPS6KB20.39472745
120FGR0.39191217
121NEK10.39110947
122TESK10.37920283
123CDK30.37217207
124TGFBR10.37110522
125STK40.35274580
126PRKCE0.34859909
127PHKG20.33989330
128PHKG10.33989330
129DAPK30.33955264
130DAPK10.33493098
131BCKDK0.31098418
132PRKDC0.31004207

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.42547314
2RNA polymerase_Homo sapiens_hsa030203.86592856
3Ribosome_Homo sapiens_hsa030103.86273195
4Oxidative phosphorylation_Homo sapiens_hsa001903.59510844
5Parkinsons disease_Homo sapiens_hsa050123.14316384
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.74898993
7DNA replication_Homo sapiens_hsa030302.72841488
8Protein export_Homo sapiens_hsa030602.71927623
9Basal transcription factors_Homo sapiens_hsa030222.65722748
10Huntingtons disease_Homo sapiens_hsa050162.61240149
11Spliceosome_Homo sapiens_hsa030402.60124820
12Mismatch repair_Homo sapiens_hsa034302.58225458
13Nucleotide excision repair_Homo sapiens_hsa034202.37962440
14RNA transport_Homo sapiens_hsa030132.30643869
15RNA degradation_Homo sapiens_hsa030182.22736772
16Alzheimers disease_Homo sapiens_hsa050102.21610441
17Pyrimidine metabolism_Homo sapiens_hsa002402.21115640
18Homologous recombination_Homo sapiens_hsa034402.20553051
19Cell cycle_Homo sapiens_hsa041102.02627493
20Fanconi anemia pathway_Homo sapiens_hsa034601.88359628
21Base excision repair_Homo sapiens_hsa034101.82321212
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.77390296
23Non-homologous end-joining_Homo sapiens_hsa034501.70995057
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.64095748
25Propanoate metabolism_Homo sapiens_hsa006401.36309282
26Purine metabolism_Homo sapiens_hsa002301.33357843
27Oocyte meiosis_Homo sapiens_hsa041141.28019267
28mRNA surveillance pathway_Homo sapiens_hsa030151.23704254
29Pyruvate metabolism_Homo sapiens_hsa006201.21778160
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18249486
31Collecting duct acid secretion_Homo sapiens_hsa049661.16177206
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10172203
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06144738
34Cardiac muscle contraction_Homo sapiens_hsa042601.04490211
35Vibrio cholerae infection_Homo sapiens_hsa051101.03432625
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02271689
37Epstein-Barr virus infection_Homo sapiens_hsa051690.99231530
38Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91245141
39Nicotine addiction_Homo sapiens_hsa050330.90090666
40Selenocompound metabolism_Homo sapiens_hsa004500.89183731
41One carbon pool by folate_Homo sapiens_hsa006700.86313051
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86052991
43Pentose and glucuronate interconversions_Homo sapiens_hsa000400.85487793
44p53 signaling pathway_Homo sapiens_hsa041150.84425385
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83354770
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83318447
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82582322
48Regulation of autophagy_Homo sapiens_hsa041400.81660412
49Fatty acid elongation_Homo sapiens_hsa000620.80639887
50Serotonergic synapse_Homo sapiens_hsa047260.80286540
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78036692
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.76966494
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75136900
54Systemic lupus erythematosus_Homo sapiens_hsa053220.70539728
55Alcoholism_Homo sapiens_hsa050340.69150005
56Ether lipid metabolism_Homo sapiens_hsa005650.68929536
57Tryptophan metabolism_Homo sapiens_hsa003800.63296345
58Butanoate metabolism_Homo sapiens_hsa006500.61970361
59Steroid biosynthesis_Homo sapiens_hsa001000.61097405
60Phototransduction_Homo sapiens_hsa047440.57555326
61beta-Alanine metabolism_Homo sapiens_hsa004100.56707157
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55893158
63Synaptic vesicle cycle_Homo sapiens_hsa047210.55755338
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53984222
65Ovarian steroidogenesis_Homo sapiens_hsa049130.52665513
66Rheumatoid arthritis_Homo sapiens_hsa053230.51481054
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50378401
68Fatty acid degradation_Homo sapiens_hsa000710.50268887
69Vitamin B6 metabolism_Homo sapiens_hsa007500.49272159
70Vitamin digestion and absorption_Homo sapiens_hsa049770.49236158
71Phagosome_Homo sapiens_hsa041450.47806359
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47168624
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46191515
74Peroxisome_Homo sapiens_hsa041460.45130682
75Linoleic acid metabolism_Homo sapiens_hsa005910.43467639
76Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42674641
77Chemical carcinogenesis_Homo sapiens_hsa052040.42621664
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42619877
79Long-term depression_Homo sapiens_hsa047300.40623847
80Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40450563
81Metabolic pathways_Homo sapiens_hsa011000.39913703
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.39313805
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39286591
84Carbon metabolism_Homo sapiens_hsa012000.38994399
85Caffeine metabolism_Homo sapiens_hsa002320.37498839
86TGF-beta signaling pathway_Homo sapiens_hsa043500.37332865
87Arachidonic acid metabolism_Homo sapiens_hsa005900.36904614
88Dopaminergic synapse_Homo sapiens_hsa047280.34774435
89Olfactory transduction_Homo sapiens_hsa047400.34681716
90Autoimmune thyroid disease_Homo sapiens_hsa053200.34245340
91Biosynthesis of amino acids_Homo sapiens_hsa012300.33750386
92Retinol metabolism_Homo sapiens_hsa008300.33522860
93Type I diabetes mellitus_Homo sapiens_hsa049400.33375437
94Graft-versus-host disease_Homo sapiens_hsa053320.32496751
95Basal cell carcinoma_Homo sapiens_hsa052170.32203885
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32153598
97Viral carcinogenesis_Homo sapiens_hsa052030.31741001
98Colorectal cancer_Homo sapiens_hsa052100.31327755
99Asthma_Homo sapiens_hsa053100.30767861
100Taste transduction_Homo sapiens_hsa047420.30551482
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.29985699
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29496387
103Arginine and proline metabolism_Homo sapiens_hsa003300.29421157
104Allograft rejection_Homo sapiens_hsa053300.27936044
105Drug metabolism - other enzymes_Homo sapiens_hsa009830.27885317
106Nitrogen metabolism_Homo sapiens_hsa009100.27788539
107Sphingolipid metabolism_Homo sapiens_hsa006000.27078194
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.27029782
109Glutathione metabolism_Homo sapiens_hsa004800.25273923
1102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.24600794
111Amphetamine addiction_Homo sapiens_hsa050310.24506188
112Sulfur metabolism_Homo sapiens_hsa009200.24078676
113Shigellosis_Homo sapiens_hsa051310.22170926
114Cocaine addiction_Homo sapiens_hsa050300.21533020
115Folate biosynthesis_Homo sapiens_hsa007900.21491649
116Sulfur relay system_Homo sapiens_hsa041220.21462284
117N-Glycan biosynthesis_Homo sapiens_hsa005100.20727351
118Tyrosine metabolism_Homo sapiens_hsa003500.19101291
119Glutamatergic synapse_Homo sapiens_hsa047240.18952272
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.18949640
121Gap junction_Homo sapiens_hsa045400.18930265
122Long-term potentiation_Homo sapiens_hsa047200.18357298
123Axon guidance_Homo sapiens_hsa043600.17342713
124Fatty acid metabolism_Homo sapiens_hsa012120.16630403
125Wnt signaling pathway_Homo sapiens_hsa043100.16031038
126Circadian rhythm_Homo sapiens_hsa047100.15611103
127Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.15249107
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.15158259
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.14619218
130Thyroid cancer_Homo sapiens_hsa052160.14231634
131Herpes simplex infection_Homo sapiens_hsa051680.14090663
132alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.14084279
133MicroRNAs in cancer_Homo sapiens_hsa052060.13331419
134Ras signaling pathway_Homo sapiens_hsa040140.13003164
135GnRH signaling pathway_Homo sapiens_hsa049120.12291277
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.12216090
137Melanoma_Homo sapiens_hsa052180.11193091
138Hippo signaling pathway_Homo sapiens_hsa043900.10851368
139HTLV-I infection_Homo sapiens_hsa051660.10221140
140Hedgehog signaling pathway_Homo sapiens_hsa043400.09821307
141Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.08677369

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