PFKFB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of acute inflammatory response (GO:0002674)6.76308908
2positive regulation of glycolytic process (GO:0045821)6.64974063
3positive regulation of protein autophosphorylation (GO:0031954)6.05100638
4negative regulation of protein oligomerization (GO:0032460)5.89577239
5positive regulation of respiratory burst (GO:0060267)5.79106067
6ketone body metabolic process (GO:1902224)5.62395824
7cellular ketone body metabolic process (GO:0046950)5.45939876
8fatty acid homeostasis (GO:0055089)5.45607010
9negative regulation of gluconeogenesis (GO:0045721)5.39666613
10regulation of rhodopsin mediated signaling pathway (GO:0022400)4.87775682
11negative regulation of glycogen metabolic process (GO:0070874)4.79222752
12inositol phosphate dephosphorylation (GO:0046855)4.78447806
13phosphorylated carbohydrate dephosphorylation (GO:0046838)4.78447806
14rhodopsin mediated signaling pathway (GO:0016056)4.76629024
15negative regulation of neurological system process (GO:0031645)4.40632276
16negative regulation of hormone biosynthetic process (GO:0032353)4.34813734
17ER overload response (GO:0006983)4.32530575
18polyol catabolic process (GO:0046174)4.26866336
19histamine secretion (GO:0001821)4.22768791
20detection of calcium ion (GO:0005513)4.22455387
21negative regulation of Ras GTPase activity (GO:0034261)4.10366642
22photoreceptor cell maintenance (GO:0045494)4.07751892
23positive regulation of growth hormone secretion (GO:0060124)4.02078682
24negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.99039579
25regulation of glycolytic process (GO:0006110)3.97735617
26photoreceptor cell development (GO:0042461)3.95538509
27positive regulation of insulin receptor signaling pathway (GO:0046628)3.95454777
28positive regulation of glycogen biosynthetic process (GO:0045725)3.92644022
29regulation of energy homeostasis (GO:2000505)3.91739544
30regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.89143315
31positive regulation of vasodilation (GO:0045909)3.87210272
32Golgi transport vesicle coating (GO:0048200)3.84504195
33COPI coating of Golgi vesicle (GO:0048205)3.84504195
34eye photoreceptor cell development (GO:0042462)3.83184394
35negative regulation of bone resorption (GO:0045779)3.80440081
36* positive regulation of peptide hormone secretion (GO:0090277)3.76579978
37negative regulation of hormone metabolic process (GO:0032351)3.73892158
38dendritic spine morphogenesis (GO:0060997)3.71339526
39* positive regulation of peptide secretion (GO:0002793)3.61624677
40neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.61531472
41insulin secretion (GO:0030073)3.61270611
42regulation of protein autophosphorylation (GO:0031952)3.60558017
43response to pheromone (GO:0019236)3.56539334
44zinc ion transport (GO:0006829)3.39016894
45endocrine pancreas development (GO:0031018)3.38869774
46type B pancreatic cell development (GO:0003323)3.37801422
47water-soluble vitamin biosynthetic process (GO:0042364)3.35774275
48regulation of carbohydrate catabolic process (GO:0043470)3.35578423
49regulation of cellular carbohydrate catabolic process (GO:0043471)3.35578423
50retinal cone cell development (GO:0046549)3.35192406
51detection of light stimulus involved in sensory perception (GO:0050962)3.34653334
52detection of light stimulus involved in visual perception (GO:0050908)3.34653334
53regulation of type B pancreatic cell apoptotic process (GO:2000674)3.33326779
54negative regulation of dendrite morphogenesis (GO:0050774)3.32775497
55histamine transport (GO:0051608)3.29704396
56nucleoside diphosphate catabolic process (GO:0009134)3.29142671
57positive regulation of glycogen metabolic process (GO:0070875)3.29140767
58membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.14113079
59regulation of synaptic vesicle exocytosis (GO:2000300)3.14038780
60zinc ion homeostasis (GO:0055069)3.13742533
61regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.13442475
62keratinocyte development (GO:0003334)3.09458532
63relaxation of cardiac muscle (GO:0055119)3.09226276
64prenylation (GO:0097354)3.09111331
65protein prenylation (GO:0018342)3.09111331
66positive regulation of nitric-oxide synthase activity (GO:0051000)3.08028359
67cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.07407999
68regulation of protein glycosylation (GO:0060049)3.07273523
69kidney morphogenesis (GO:0060993)3.06688893
70photoreceptor cell differentiation (GO:0046530)3.06443642
71eye photoreceptor cell differentiation (GO:0001754)3.06443642
72negative regulation of glial cell proliferation (GO:0060253)3.03781701
73peptide hormone processing (GO:0016486)3.00294817
74regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.99111553
75righting reflex (GO:0060013)2.98914283
76zinc ion transmembrane transport (GO:0071577)2.98673569
77positive regulation of glycoprotein biosynthetic process (GO:0010560)2.98569763
78regulation of short-term neuronal synaptic plasticity (GO:0048172)2.98429888
79protein-chromophore linkage (GO:0018298)2.97927392
80positive regulation of actin filament depolymerization (GO:0030836)2.96869528
81regulation of feeding behavior (GO:0060259)2.95904160
82regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.95140241
83regulation of steroid hormone biosynthetic process (GO:0090030)2.93345110
84* positive regulation of hormone secretion (GO:0046887)2.92479196
85inner ear receptor cell development (GO:0060119)2.92289154
86parental behavior (GO:0060746)2.90724352
87brain morphogenesis (GO:0048854)2.89620799
88regulation of B cell apoptotic process (GO:0002902)2.89286247
89negative regulation of bone remodeling (GO:0046851)2.88450698
90positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.86963726
91regulation of synaptic vesicle transport (GO:1902803)2.86526837
92regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.85684233
93positive regulation of macroautophagy (GO:0016239)2.85518051
94presynaptic membrane assembly (GO:0097105)2.84807379
95regulation of respiratory burst (GO:0060263)2.84549560
96regulation of growth hormone secretion (GO:0060123)2.82302677
97regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.81504552
98retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.81337007
99negative regulation of dendrite development (GO:2000171)2.80703027
100protein K11-linked deubiquitination (GO:0035871)2.79429649
101signal peptide processing (GO:0006465)2.79262137
102regulation of glucocorticoid metabolic process (GO:0031943)2.78771122
103startle response (GO:0001964)2.78354076
104* regulation of insulin secretion (GO:0050796)2.76554947
105respiratory chain complex IV assembly (GO:0008535)2.75768725
106calcium ion import (GO:0070509)2.75161223
107positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.72982686
108positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.72982686
109positive regulation of mitotic sister chromatid separation (GO:1901970)2.72982686
110urinary tract smooth muscle contraction (GO:0014848)2.72928854
111retinal rod cell development (GO:0046548)2.72012685
112phototransduction (GO:0007602)2.71857975
113positive regulation of response to nutrient levels (GO:0032109)2.71075419
114positive regulation of response to extracellular stimulus (GO:0032106)2.71075419
115ferric iron transport (GO:0015682)2.70191712
116trivalent inorganic cation transport (GO:0072512)2.70191712
117regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.69214771
118chemosensory behavior (GO:0007635)2.68976735
119positive regulation of glucose metabolic process (GO:0010907)2.67971158
120phototransduction, visible light (GO:0007603)2.67409436
121striatum development (GO:0021756)2.67264155
122detection of visible light (GO:0009584)2.67007916
123regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.65800998
124detection of light stimulus (GO:0009583)2.64577770
125glandular epithelial cell differentiation (GO:0002067)2.64498296
126synaptic vesicle docking involved in exocytosis (GO:0016081)2.63658749
127nonmotile primary cilium assembly (GO:0035058)2.63506023
128regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.63343106
129regulation of vasodilation (GO:0042312)2.62957232
130positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.62871041
131cardiac conduction (GO:0061337)2.61631408
132intra-Golgi vesicle-mediated transport (GO:0006891)2.60584678
133sarcoplasmic reticulum calcium ion transport (GO:0070296)2.60308663
134negative regulation of catecholamine secretion (GO:0033604)2.59234719
135protein targeting to Golgi (GO:0000042)2.58772818
136sensory perception of light stimulus (GO:0050953)2.57734816
137visual perception (GO:0007601)2.56635815
138positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.55077830
139cell communication by electrical coupling (GO:0010644)2.53909317
140cell communication involved in cardiac conduction (GO:0086065)2.53334872
141intraciliary transport (GO:0042073)2.50806074
142* regulation of peptide hormone secretion (GO:0090276)2.50394862
143regulation of heart rate by cardiac conduction (GO:0086091)2.50168539
144protein localization to Golgi apparatus (GO:0034067)2.48673938
145* regulation of peptide secretion (GO:0002791)2.46892398
146neurotransmitter-gated ion channel clustering (GO:0072578)2.45480496
147phosphorelay signal transduction system (GO:0000160)2.44036331
148negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.43094851
149negative regulation of calcium ion transmembrane transport (GO:1903170)2.43094851
150peptide hormone secretion (GO:0030072)2.38820647
151relaxation of muscle (GO:0090075)2.38380428
152response to redox state (GO:0051775)2.37360582
153innervation (GO:0060384)2.35629615
154maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.34066318
155peptide secretion (GO:0002790)2.34027191
156behavioral response to ethanol (GO:0048149)2.33902326
157protein maturation by protein folding (GO:0022417)2.33304594
158negative regulation of norepinephrine secretion (GO:0010700)2.32432486
159detection of chemical stimulus (GO:0009593)2.32368628
160membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.32130641
161positive regulation of vesicle fusion (GO:0031340)2.31793649
162presynaptic membrane organization (GO:0097090)2.31649154
163retrograde transport, vesicle recycling within Golgi (GO:0000301)2.30052325
164pharyngeal system development (GO:0060037)2.29547900
165positive regulation of guanylate cyclase activity (GO:0031284)2.29476999
166postsynaptic membrane organization (GO:0001941)2.29461249
167synaptic vesicle endocytosis (GO:0048488)2.27616962
168membrane depolarization during action potential (GO:0086010)2.27370399
169establishment of protein localization to Golgi (GO:0072600)2.27007958
170nitric oxide mediated signal transduction (GO:0007263)2.25740169
171macroautophagy (GO:0016236)2.25241455
172prostate gland growth (GO:0060736)2.23219894
173* regulation of hormone secretion (GO:0046883)2.23156098
174synaptic vesicle exocytosis (GO:0016079)2.22203197
175sequestering of metal ion (GO:0051238)2.21786412
176* positive regulation of insulin secretion (GO:0032024)2.21060205
177inositol phosphate catabolic process (GO:0071545)2.20811449
178potassium ion transmembrane transport (GO:0071805)2.20104753

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.82225710
2EZH2_22144423_ChIP-Seq_EOC_Human2.91567562
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.80594370
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.51117779
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.39161654
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08815542
7* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.00585069
8RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.97535647
9SMAD4_21799915_ChIP-Seq_A2780_Human1.92900023
10ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84679249
11REST_21632747_ChIP-Seq_MESCs_Mouse1.82009041
12PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80942750
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.78430096
14DROSHA_22980978_ChIP-Seq_HELA_Human1.77467745
15SALL1_21062744_ChIP-ChIP_HESCs_Human1.74620537
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.73526462
17EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.73233659
18PIAS1_25552417_ChIP-Seq_VCAP_Human1.73172265
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65184227
20ZNF217_24962896_ChIP-Seq_MCF-7_Human1.64799349
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.64520556
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.63631455
23P300_19829295_ChIP-Seq_ESCs_Human1.61519775
24AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.60574052
25* STAT3_23295773_ChIP-Seq_U87_Human1.60542433
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.59717033
27FUS_26573619_Chip-Seq_HEK293_Human1.59485117
28MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56321185
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53660814
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49072456
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.48210335
32CDX2_22108803_ChIP-Seq_LS180_Human1.47059063
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.46465467
34TCF4_23295773_ChIP-Seq_U87_Human1.43346187
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.42808054
36SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.41679700
37ARNT_22903824_ChIP-Seq_MCF-7_Human1.41074872
38SMAD3_21741376_ChIP-Seq_EPCs_Human1.40735840
39FLI1_27457419_Chip-Seq_LIVER_Mouse1.40659624
40TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40300746
41AHR_22903824_ChIP-Seq_MCF-7_Human1.39570455
42JARID2_20075857_ChIP-Seq_MESCs_Mouse1.39466821
43* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39214417
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.39064513
45* NANOG_18555785_Chip-Seq_ESCs_Mouse1.38854121
46TAF15_26573619_Chip-Seq_HEK293_Human1.38621935
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38093698
48* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37222341
49GATA1_22025678_ChIP-Seq_K562_Human1.37036951
50JARID2_20064375_ChIP-Seq_MESCs_Mouse1.37018943
51EP300_21415370_ChIP-Seq_HL-1_Mouse1.35050659
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34372446
53RNF2_27304074_Chip-Seq_ESCs_Mouse1.32993732
54NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32884963
55* CRX_20693478_ChIP-Seq_RETINA_Mouse1.32368318
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.32262940
57EZH2_27294783_Chip-Seq_ESCs_Mouse1.31950890
58* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.31604912
59EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31588888
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.30243682
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29836077
62CBP_20019798_ChIP-Seq_JUKART_Human1.29836077
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29710911
64SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.29535557
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29180504
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27645422
67RARB_27405468_Chip-Seq_BRAIN_Mouse1.27212248
68CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.27144030
69EED_16625203_ChIP-ChIP_MESCs_Mouse1.27101107
70ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.26426469
71IGF1R_20145208_ChIP-Seq_DFB_Human1.25957681
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24466644
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23376460
74NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22747956
75AR_25329375_ChIP-Seq_VCAP_Human1.22336626
76SOX2_19829295_ChIP-Seq_ESCs_Human1.21384278
77NANOG_19829295_ChIP-Seq_ESCs_Human1.21384278
78ZNF274_21170338_ChIP-Seq_K562_Hela1.20626742
79* E2F1_18555785_Chip-Seq_ESCs_Mouse1.20564669
80* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20418062
81* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20401489
82* P300_18555785_Chip-Seq_ESCs_Mouse1.20280096
83FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.20258111
84TP53_22573176_ChIP-Seq_HFKS_Human1.20250539
85* P53_22387025_ChIP-Seq_ESCs_Mouse1.19862536
86EZH2_18974828_ChIP-Seq_MESCs_Mouse1.19797540
87RNF2_18974828_ChIP-Seq_MESCs_Mouse1.19797540
88SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19712737
89* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.19554409
90EWS_26573619_Chip-Seq_HEK293_Human1.19417038
91RUNX2_22187159_ChIP-Seq_PCA_Human1.19245678
92* CTCF_18555785_Chip-Seq_ESCs_Mouse1.18704217
93REST_18959480_ChIP-ChIP_MESCs_Mouse1.17639828
94AR_19668381_ChIP-Seq_PC3_Human1.17088371
95KLF5_20875108_ChIP-Seq_MESCs_Mouse1.16741391
96HTT_18923047_ChIP-ChIP_STHdh_Human1.16639838
97SMAD4_21741376_ChIP-Seq_EPCs_Human1.15162964
98FLI1_21867929_ChIP-Seq_TH2_Mouse1.14482541
99FOXM1_26456572_ChIP-Seq_MCF-7_Human1.14296508
100FOXA1_25329375_ChIP-Seq_VCAP_Human1.14284298
101FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14284298
102SMAD_19615063_ChIP-ChIP_OVARY_Human1.13903747
103ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12304644
104FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.12251362
105YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11813619
106DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10341930
107* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.10026854
108* STAT3_18555785_Chip-Seq_ESCs_Mouse1.10008963
109EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09854994
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09612678
111ER_23166858_ChIP-Seq_MCF-7_Human1.08856770
112* CMYC_18555785_Chip-Seq_ESCs_Mouse1.07861006
113BCAT_22108803_ChIP-Seq_LS180_Human1.07832935
114* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07791533
115KDM2B_26808549_Chip-Seq_REH_Human1.07769472
116* NFE2_27457419_Chip-Seq_LIVER_Mouse1.07722419
117TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07678307
118AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.07554137
119TBL1_22424771_ChIP-Seq_293T_Human1.06902264
120ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06485020
121* NMYC_18555785_Chip-Seq_ESCs_Mouse1.05521899
122* ZFX_18555785_Chip-Seq_ESCs_Mouse1.05182277
123FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04923067
124LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04850100
125TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04650749
126* PU1_27457419_Chip-Seq_LIVER_Mouse1.04422387
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04199122
128POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04199122
129UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04128784
130GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03880818
131* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03600106
132NFYB_21822215_ChIP-Seq_K562_Human1.03265528
133* EZH2_27294783_Chip-Seq_NPCs_Mouse1.02765964
134VDR_22108803_ChIP-Seq_LS180_Human1.02470765
135* SOX2_18555785_Chip-Seq_ESCs_Mouse1.01426871
136TCF4_22108803_ChIP-Seq_LS180_Human1.01331544
137P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01239359
138TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00342882
139ESR1_20079471_ChIP-ChIP_T-47D_Human0.99907733
140RXR_22108803_ChIP-Seq_LS180_Human0.99901879
141RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99550329

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.07347348
2MP0005551_abnormal_eye_electrophysiolog3.87299354
3MP0002837_dystrophic_cardiac_calcinosis3.65591088
4MP0001986_abnormal_taste_sensitivity3.51320966
5MP0009780_abnormal_chondrocyte_physiolo3.42697067
6MP0006072_abnormal_retinal_apoptosis3.25556524
7MP0005646_abnormal_pituitary_gland3.16102709
8MP0004043_abnormal_pH_regulation3.09690518
9MP0003123_paternal_imprinting3.04374514
10MP0010386_abnormal_urinary_bladder2.95509086
11MP0002102_abnormal_ear_morphology2.83917882
12MP0005253_abnormal_eye_physiology2.77446147
13MP0002877_abnormal_melanocyte_morpholog2.66782048
14MP0002693_abnormal_pancreas_physiology2.37234392
15MP0005075_abnormal_melanosome_morpholog2.32887506
16MP0004270_analgesia2.31965636
17MP0002163_abnormal_gland_morphology2.29899888
18MP0000678_abnormal_parathyroid_gland2.28950871
19MP0002638_abnormal_pupillary_reflex2.25536907
20MP0008877_abnormal_DNA_methylation2.23020575
21MP0003183_abnormal_peptide_metabolism2.17890347
22MP0000372_irregular_coat_pigmentation2.17584199
23MP0003011_delayed_dark_adaptation2.06717140
24MP0002909_abnormal_adrenal_gland2.03472767
25MP0010678_abnormal_skin_adnexa1.92849365
26MP0010352_gastrointestinal_tract_polyps1.90427844
27MP0001944_abnormal_pancreas_morphology1.89998902
28MP0000569_abnormal_digit_pigmentation1.89045754
29MP0001984_abnormal_olfaction1.86187396
30MP0005379_endocrine/exocrine_gland_phen1.77556598
31MP0003121_genomic_imprinting1.75904489
32MP0004859_abnormal_synaptic_plasticity1.73802472
33MP0005645_abnormal_hypothalamus_physiol1.72493873
34MP0003172_abnormal_lysosome_physiology1.72400790
35MP0003195_calcinosis1.68348789
36MP0000013_abnormal_adipose_tissue1.67189913
37MP0001502_abnormal_circadian_rhythm1.65676682
38MP0002938_white_spotting1.62981734
39MP0002876_abnormal_thyroid_physiology1.61139905
40MP0004215_abnormal_myocardial_fiber1.58009455
41MP0003635_abnormal_synaptic_transmissio1.57512931
42MP0002078_abnormal_glucose_homeostasis1.57018904
43MP0002822_catalepsy1.49765807
44MP0001486_abnormal_startle_reflex1.48574197
45MP0002229_neurodegeneration1.47616770
46MP0005174_abnormal_tail_pigmentation1.46894408
47MP0000427_abnormal_hair_cycle1.44618973
48MP0001324_abnormal_eye_pigmentation1.43189606
49MP0002734_abnormal_mechanical_nocicepti1.42299429
50MP0003787_abnormal_imprinting1.41690130
51MP0004264_abnormal_extraembryonic_tissu1.41682713
52MP0005408_hypopigmentation1.40884164
53MP0001501_abnormal_sleep_pattern1.38969592
54MP0002272_abnormal_nervous_system1.37612657
55MP0009745_abnormal_behavioral_response1.37193493
56MP0002090_abnormal_vision1.36596640
57MP0002063_abnormal_learning/memory/cond1.35683827
58MP0005195_abnormal_posterior_eye1.35219031
59MP0004085_abnormal_heartbeat1.34481251
60MP0001756_abnormal_urination1.33763267
61MP0002572_abnormal_emotion/affect_behav1.32990743
62MP0003045_fibrosis1.31254950
63MP0005423_abnormal_somatic_nervous1.30844403
64MP0001661_extended_life_span1.29148449
65MP0003122_maternal_imprinting1.28074860
66MP0003950_abnormal_plasma_membrane1.27994942
67MP0005220_abnormal_exocrine_pancreas1.27137268
68MP0000015_abnormal_ear_pigmentation1.24375585
69MP0002064_seizures1.22943641
70MP0000462_abnormal_digestive_system1.22397193
71MP0003283_abnormal_digestive_organ1.21282984
72MP0006036_abnormal_mitochondrial_physio1.21061143
73MP0005332_abnormal_amino_acid1.16898380
74MP0002127_abnormal_cardiovascular_syste1.15622015
75MP0003868_abnormal_feces_composition1.13767515
76MP0002735_abnormal_chemical_nociception1.12937210
77MP0002095_abnormal_skin_pigmentation1.11846823
78MP0002277_abnormal_respiratory_mucosa1.11732854
79MP0004782_abnormal_surfactant_physiolog1.11535173
80MP0005386_behavior/neurological_phenoty1.07704090
81MP0004924_abnormal_behavior1.07704090
82MP0001727_abnormal_embryo_implantation1.07627356
83MP0001188_hyperpigmentation1.07398536
84MP0004036_abnormal_muscle_relaxation1.06104539
85MP0004885_abnormal_endolymph1.05500795
86MP0005636_abnormal_mineral_homeostasis1.04781459
87MP0002557_abnormal_social/conspecific_i1.04486891
88MP0000371_diluted_coat_color1.02798507
89MP0001905_abnormal_dopamine_level1.02612647
90MP0003953_abnormal_hormone_level1.02415230
91MP0009046_muscle_twitch1.02121244
92MP0005365_abnormal_bile_salt1.01676362
93MP0000749_muscle_degeneration1.01392025
94MP0002928_abnormal_bile_duct1.00529214
95MP0002067_abnormal_sensory_capabilities0.99329934
96MP0006292_abnormal_olfactory_placode0.99079489
97MP0000631_abnormal_neuroendocrine_gland0.98791651
98MP0010329_abnormal_lipoprotein_level0.98332487
99MP0003633_abnormal_nervous_system0.97714032
100MP0001764_abnormal_homeostasis0.97548468
101MP0001968_abnormal_touch/_nociception0.97372420
102MP0005535_abnormal_body_temperature0.97086605
103MP0008961_abnormal_basal_metabolism0.95007513
104MP0003879_abnormal_hair_cell0.94974636
105MP0002882_abnormal_neuron_morphology0.93816577
106MP0002166_altered_tumor_susceptibility0.93345943
107MP0005391_vision/eye_phenotype0.91775672
108MP0004145_abnormal_muscle_electrophysio0.91000371
109MP0005367_renal/urinary_system_phenotyp0.90293740
110MP0000516_abnormal_urinary_system0.90293740
111MP0004233_abnormal_muscle_weight0.90132006
112MP0002118_abnormal_lipid_homeostasis0.89920750
113MP0003252_abnormal_bile_duct0.89849098
114MP0002160_abnormal_reproductive_system0.89138254
115MP0005187_abnormal_penis_morphology0.88184505
116MP0005670_abnormal_white_adipose0.87786973
117MP0003137_abnormal_impulse_conducting0.87319311
118MP0005171_absent_coat_pigmentation0.87068593
119MP0001970_abnormal_pain_threshold0.86439551
120MP0005257_abnormal_intraocular_pressure0.84981697
121MP0005448_abnormal_energy_balance0.84784751
122MP0000003_abnormal_adipose_tissue0.84418221
123MP0000681_abnormal_thyroid_gland0.84141591
124MP0009643_abnormal_urine_homeostasis0.83846029
125MP0008569_lethality_at_weaning0.82865000
126MP0001177_atelectasis0.80742345
127MP0002733_abnormal_thermal_nociception0.80494913
128MP0004084_abnormal_cardiac_muscle0.79851599
129MP0002752_abnormal_somatic_nervous0.79611710
130MP0002896_abnormal_bone_mineralization0.78989725
131MP0006276_abnormal_autonomic_nervous0.78165682
132MP0002972_abnormal_cardiac_muscle0.77461371
133MP0001765_abnormal_ion_homeostasis0.77204927
134MP0005620_abnormal_muscle_contractility0.75534477
135MP0003646_muscle_fatigue0.75332205
136MP0005389_reproductive_system_phenotype0.71491111
137MP0000647_abnormal_sebaceous_gland0.70797117
138MP0008872_abnormal_physiological_respon0.70669711
139MP0004142_abnormal_muscle_tone0.69427471
140MP0001440_abnormal_grooming_behavior0.69020260
141MP0000383_abnormal_hair_follicle0.68704033
142MP0005452_abnormal_adipose_tissue0.68510634
143MP0003943_abnormal_hepatobiliary_system0.67551024
144MP0003718_maternal_effect0.66599955
145MP0003806_abnormal_nucleotide_metabolis0.66547559
146MP0000538_abnormal_urinary_bladder0.66290649
147MP0002075_abnormal_coat/hair_pigmentati0.64915729
148MP0004134_abnormal_chest_morphology0.64206991
149MP0000639_abnormal_adrenal_gland0.61333780
150MP0004381_abnormal_hair_follicle0.58957132
151MP0000377_abnormal_hair_follicle0.56034516
152MP0004019_abnormal_vitamin_homeostasis0.55960848

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)6.26128086
2Bony spicule pigmentary retinopathy (HP:0007737)5.61999232
3Central scotoma (HP:0000603)5.02354353
4Abnormal rod and cone electroretinograms (HP:0008323)4.92209539
5Hyperinsulinemic hypoglycemia (HP:0000825)4.79214078
6Absent rod-and cone-mediated responses on ERG (HP:0007688)4.57592336
7Hypoglycemic seizures (HP:0002173)4.47662987
8Prominent metopic ridge (HP:0005487)4.19975799
9Attenuation of retinal blood vessels (HP:0007843)4.00288286
10Symptomatic seizures (HP:0011145)3.98498888
11Dyschromatopsia (HP:0007641)3.85226491
12Ketosis (HP:0001946)3.84141380
13Enlarged penis (HP:0000040)3.80009011
14Neoplasm of the adrenal cortex (HP:0100641)3.79707935
15Scotoma (HP:0000575)3.76347748
16Congenital sensorineural hearing impairment (HP:0008527)3.67196930
17Pigmentary retinal degeneration (HP:0001146)3.66461121
18Abnormality of the metopic suture (HP:0005556)3.62240216
19Decreased central vision (HP:0007663)3.61020430
20Abnormality of macular pigmentation (HP:0008002)3.49449139
21Hypoglycemic coma (HP:0001325)3.46937705
22Chorioretinal atrophy (HP:0000533)3.40002856
23Hamartoma of the eye (HP:0010568)3.34091745
24Insulin-resistant diabetes mellitus (HP:0000831)3.31061646
25Late onset (HP:0003584)3.29406672
26Conjugated hyperbilirubinemia (HP:0002908)3.29262122
27Decreased circulating renin level (HP:0003351)3.27650697
28Conjunctival hamartoma (HP:0100780)3.27318019
29Hyperglycemia (HP:0003074)3.26114883
30Type II diabetes mellitus (HP:0005978)3.20046831
31Hypomagnesemia (HP:0002917)3.18876442
32Tongue fasciculations (HP:0001308)3.13228443
33Type I diabetes mellitus (HP:0100651)3.05175503
34Hematochezia (HP:0002573)2.97731129
35Chronic hepatic failure (HP:0100626)2.86929990
36Ketoacidosis (HP:0001993)2.83710278
37Cutaneous melanoma (HP:0012056)2.81700179
38Hyperthyroidism (HP:0000836)2.79907425
39Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.77719863
40Pancreatic fibrosis (HP:0100732)2.77573980
41Gait imbalance (HP:0002141)2.77468427
42Febrile seizures (HP:0002373)2.75346534
43Congenital primary aphakia (HP:0007707)2.74801717
44Medial flaring of the eyebrow (HP:0010747)2.74108096
45Papillary thyroid carcinoma (HP:0002895)2.72532272
46Muscle fibrillation (HP:0010546)2.72242684
47Abolished electroretinogram (ERG) (HP:0000550)2.71802650
48Osteomalacia (HP:0002749)2.71632886
49Photophobia (HP:0000613)2.71191820
50Focal motor seizures (HP:0011153)2.70279231
51Hemiparesis (HP:0001269)2.68625332
52Hypokinesia (HP:0002375)2.67849549
53Retinitis pigmentosa (HP:0000510)2.66938038
54Nephrogenic diabetes insipidus (HP:0009806)2.62915229
55Pancreatic islet-cell hyperplasia (HP:0004510)2.62191801
56Syncope (HP:0001279)2.60626737
57Cystic liver disease (HP:0006706)2.57997642
58Progressive macrocephaly (HP:0004481)2.54324833
59True hermaphroditism (HP:0010459)2.54282872
60Aplasia/Hypoplasia of the fovea (HP:0008060)2.53341241
61Hypoplasia of the fovea (HP:0007750)2.53341241
62Prolonged QT interval (HP:0001657)2.52471869
63Neoplasm of the adrenal gland (HP:0100631)2.50977574
64Abnormality of the pancreatic islet cells (HP:0006476)2.47474397
65Abnormality of endocrine pancreas physiology (HP:0012093)2.47474397
66Downturned corners of mouth (HP:0002714)2.46000845
67Asymmetry of the thorax (HP:0001555)2.44493447
68Epileptic encephalopathy (HP:0200134)2.43788262
69Constricted visual fields (HP:0001133)2.42832233
70Retinal atrophy (HP:0001105)2.41022107
71Abnormality of magnesium homeostasis (HP:0004921)2.40352316
72Hypothermia (HP:0002045)2.38317889
73Testicular neoplasm (HP:0010788)2.35874975
74Large for gestational age (HP:0001520)2.34995185
75Increased circulating renin level (HP:0000848)2.34763856
76Absent eyebrow (HP:0002223)2.34471355
77Progressive visual loss (HP:0000529)2.34377287
78Macroorchidism (HP:0000053)2.33708802
79Hepatic necrosis (HP:0002605)2.30660955
80Atrial fibrillation (HP:0005110)2.28954152
81Muscular hypotonia of the trunk (HP:0008936)2.28346492
82Abnormality of the fovea (HP:0000493)2.27396879
83Aqueductal stenosis (HP:0002410)2.26391059
84Hyperventilation (HP:0002883)2.26033088
85Pendular nystagmus (HP:0012043)2.22746297
86Cone-rod dystrophy (HP:0000548)2.22233406
87Epileptiform EEG discharges (HP:0011182)2.21916752
88Thyroiditis (HP:0100646)2.21539921
89EEG with generalized epileptiform discharges (HP:0011198)2.21001165
90Poor coordination (HP:0002370)2.19685333
91Neoplasm of the tracheobronchial system (HP:0100552)2.18138284
92Abnormal pancreas size (HP:0012094)2.12161262
93Visual hallucinations (HP:0002367)2.10921201
94Heterochromia iridis (HP:0001100)2.10325812
95Left ventricular hypertrophy (HP:0001712)2.10133542
96Hypsarrhythmia (HP:0002521)2.09802726
97Sensory axonal neuropathy (HP:0003390)2.08535559
98Methylmalonic acidemia (HP:0002912)2.07461057
99Aplasia/Hypoplasia of the macula (HP:0008059)2.06759827
100Abnormality of calcium-phosphate metabolism (HP:0100530)2.05942982
101Patchy hypopigmentation of hair (HP:0011365)2.03686087
102Vaginal atresia (HP:0000148)2.02444952
103Primary atrial arrhythmia (HP:0001692)2.01898670
104Calf muscle hypertrophy (HP:0008981)2.01703662
105Hyperkalemia (HP:0002153)2.01378141
106Gaze-evoked nystagmus (HP:0000640)2.00964414
107Genital tract atresia (HP:0001827)2.00363758
108Hypobetalipoproteinemia (HP:0003563)1.99586138
109Abnormality of methionine metabolism (HP:0010901)1.99046451
110Macular degeneration (HP:0000608)1.97849329
111Blue irides (HP:0000635)1.97598461
112Abnormality of midbrain morphology (HP:0002418)1.97447199
113Molar tooth sign on MRI (HP:0002419)1.97447199
114Amblyopia (HP:0000646)1.97259182
115Generalized aminoaciduria (HP:0002909)1.96946686
116Insulin resistance (HP:0000855)1.96669808
117Choroideremia (HP:0001139)1.96609074
118Hypokalemia (HP:0002900)1.96005874
119Stridor (HP:0010307)1.95372682
120Abnormal hair whorl (HP:0010721)1.94793246
121Abnormality of renin-angiotensin system (HP:0000847)1.93785074
122Aplasia/Hypoplasia affecting the retina (HP:0008061)1.91665199
123Lymphangioma (HP:0100764)1.91528343
124Abnormal drinking behavior (HP:0030082)1.91375610
125Polydipsia (HP:0001959)1.91375610
126Furrowed tongue (HP:0000221)1.91006745
127Diminished movement (HP:0002374)1.90283672
128Keratoconus (HP:0000563)1.90039077
129Increased corneal curvature (HP:0100692)1.90039077
130Progressive sensorineural hearing impairment (HP:0000408)1.89073317
131Urethral obstruction (HP:0000796)1.88421569
132Abnormality of vitamin B metabolism (HP:0004340)1.86109987
133Abnormality of potassium homeostasis (HP:0011042)1.85096966
134Pancreatic cysts (HP:0001737)1.84911631
135Lip pit (HP:0100267)1.84550993
136Bradycardia (HP:0001662)1.84331555
137Abnormality of the intrinsic pathway (HP:0010989)1.83455383
138Abnormal EKG (HP:0003115)1.83252508
139White forelock (HP:0002211)1.83018691
140Renal cortical cysts (HP:0000803)1.82971955
141Frequent falls (HP:0002359)1.82737801
142Hyperactive renin-angiotensin system (HP:0000841)1.82668562
143Atonic seizures (HP:0010819)1.81108511
144Hyperphosphatemia (HP:0002905)1.80998016
145Villous atrophy (HP:0011473)1.80526911
146Abnormality of small intestinal villus morphology (HP:0011472)1.80526911
147Bilateral sensorineural hearing impairment (HP:0008619)1.80284419
148Angiofibromas (HP:0010615)1.80139903
149Adenoma sebaceum (HP:0009720)1.80139903
150Tubulointerstitial nephritis (HP:0001970)1.79197916
151Metaphyseal dysplasia (HP:0100255)1.77856935
152Supraventricular tachycardia (HP:0004755)1.77776514
153Muscle hypertrophy of the lower extremities (HP:0008968)1.76103030
154Lower limb hyperreflexia (HP:0002395)1.74511849
155Thyroid carcinoma (HP:0002890)1.74366121
156Aplasia/Hypoplasia of the lens (HP:0008063)1.73224892
157Abnormality of the renal cortex (HP:0011035)1.71997700
158Severe visual impairment (HP:0001141)1.71842164
159Supraventricular arrhythmia (HP:0005115)1.70005978
160Protruding tongue (HP:0010808)1.69507024
161Acute hepatic failure (HP:0006554)1.68121188
162Occipital encephalocele (HP:0002085)1.67257201
163Small for gestational age (HP:0001518)1.66916578
164Bundle branch block (HP:0011710)1.66392067
165Abnormality of aspartate family amino acid metabolism (HP:0010899)1.65903948
166Abnormality of aromatic amino acid family metabolism (HP:0004338)1.65883221
167Malnutrition (HP:0004395)1.65865295
168Albinism (HP:0001022)1.64292576
169Agitation (HP:0000713)1.62664275
170Breast carcinoma (HP:0003002)1.62332043
171Bone cyst (HP:0012062)1.61573683
172Methylmalonic aciduria (HP:0012120)1.59306161
173Tetany (HP:0001281)1.59149449
174Hypoalbuminemia (HP:0003073)1.57444685
175Abnormal albumin level (HP:0012116)1.57444685

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.40963238
2FRK3.01285922
3AKT33.00083949
4MST42.85897016
5NTRK32.51172087
6PRKD32.49215056
7TAOK32.42084760
8SGK22.34338756
9CASK2.28841479
10SIK32.01359000
11TRIM281.98008276
12STK161.92794948
13GRK11.92234372
14MAP3K41.87210849
15PRPF4B1.83712618
16PINK11.76287115
17CDC42BPA1.74925448
18SGK31.68532095
19SGK2231.67252190
20SGK4941.67252190
21ERBB31.66870251
22MAP2K71.59618763
23STK38L1.51757095
24MAP3K21.50015097
25TNIK1.49904378
26NLK1.48826652
27LATS11.48003104
28ACVR1B1.47671803
29BMPR21.43418475
30HIPK21.43082255
31STK31.35422632
32ZAK1.28058062
33CSNK1G11.27843815
34MAPK151.26913487
35STK381.26264207
36PASK1.23316070
37BRD41.17843742
38RIPK11.17201747
39WNK11.17197730
40BMPR1B1.16727851
41PTK2B1.15966340
42PRKCH1.11366256
43PIK3CA1.10273748
44PLK31.09070008
45OXSR11.08076054
46PRKCE1.07886338
47MAPK131.04973338
48STK391.03372107
49CDK31.02120747
50CAMK1G1.01372034
51CSNK1G31.00408458
52MAP4K20.95448897
53SGK10.94822302
54TRPM70.94125732
55CSNK1G20.94044988
56MKNK20.93417084
57NEK60.92129035
58WNK30.89495774
59LMTK20.87316263
60CAMK2D0.85488902
61WNK40.84883400
62GRK70.83772579
63CAMKK20.83669166
64EPHA40.83485435
65SIK10.82822167
66RPS6KA20.80953921
67EIF2AK30.80921581
68PLK20.80121037
69FGFR20.79617968
70OBSCN0.79577825
71EIF2AK10.77920073
72CAMK1D0.77760908
73RPS6KB10.75605683
74IRAK20.74326484
75STK110.72487785
76MARK10.72194748
77STK240.72176193
78PHKG10.70105375
79PHKG20.70105375
80MAP2K60.66854371
81DAPK20.66555061
82IRAK30.66370381
83YES10.65703683
84PRKD20.64066257
85IRAK10.61650806
86* PRKAA10.61130258
87CAMK2A0.60162868
88SIK20.59901493
89MINK10.59004737
90MAP2K40.57599049
91CDK50.55929480
92CAMK40.55827584
93NUAK10.55775463
94MAPK70.55225433
95PRKG10.54816824
96LIMK10.54128547
97BCR0.53386569
98* PRKAA20.52896136
99PRKCG0.51259407
100CAMK10.50503134
101MUSK0.50251880
102CDK120.48366736
103PAK30.48232232
104PNCK0.47906162
105CSNK1A1L0.47305452
106MARK20.46797853
107PTK20.46654945
108FER0.46544580
109ADRBK20.45783203
110DYRK1A0.44663285
111* PRKACA0.44568847
112ROCK10.44562737
113PRKD10.43124988
114FGFR30.42801852
115CAMKK10.41489544
116TNK20.41075644
117GRK50.38648281
118MAP3K10.38501954
119EPHA30.38130890
120GSK3A0.38043997
121* RPS6KA30.37953642
122ADRBK10.36540727
123CSNK1D0.36526594
124CDK80.35987382
125* PRKACG0.35180900
126PRKCI0.33460286
127BRSK20.33409650
128MAP2K10.33092864
129WEE10.32769793
130CSNK1A10.32408659
131NTRK10.31206647
132PRKCZ0.30140089
133MAP3K30.29239015
134TYK20.28274714
135STK40.25448776
136TAOK10.24753619
137RPS6KA40.24604996
138ATM0.22225418
139* PRKCA0.22022972
140EGFR0.21951125
141IKBKB0.21696450
142SCYL20.21349006
143MAP3K70.19389946
144JAK10.19359494

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047445.56939964
2Maturity onset diabetes of the young_Homo sapiens_hsa049504.69027570
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.26779100
4Insulin secretion_Homo sapiens_hsa049113.02710045
5Protein export_Homo sapiens_hsa030602.61561569
6Vitamin B6 metabolism_Homo sapiens_hsa007502.22248804
7Type II diabetes mellitus_Homo sapiens_hsa049302.14422174
8Fatty acid elongation_Homo sapiens_hsa000621.95949247
9Circadian entrainment_Homo sapiens_hsa047131.89592672
10Olfactory transduction_Homo sapiens_hsa047401.87137282
11Sulfur metabolism_Homo sapiens_hsa009201.85212238
12Taste transduction_Homo sapiens_hsa047421.84798143
13GABAergic synapse_Homo sapiens_hsa047271.78662077
14Synaptic vesicle cycle_Homo sapiens_hsa047211.75851404
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.73322745
16Morphine addiction_Homo sapiens_hsa050321.71819153
17Amphetamine addiction_Homo sapiens_hsa050311.68157803
18Circadian rhythm_Homo sapiens_hsa047101.64447422
19Nicotine addiction_Homo sapiens_hsa050331.59221629
20Carbohydrate digestion and absorption_Homo sapiens_hsa049731.58982232
21Cocaine addiction_Homo sapiens_hsa050301.53355540
22Fatty acid metabolism_Homo sapiens_hsa012121.52187860
23Dopaminergic synapse_Homo sapiens_hsa047281.51560182
24Cholinergic synapse_Homo sapiens_hsa047251.48235661
25Glutamatergic synapse_Homo sapiens_hsa047241.42442361
26Serotonergic synapse_Homo sapiens_hsa047261.37973204
27Aldosterone synthesis and secretion_Homo sapiens_hsa049251.28629871
28Long-term potentiation_Homo sapiens_hsa047201.27112304
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.26612628
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23156527
31ABC transporters_Homo sapiens_hsa020101.22095201
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15722156
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15681281
34Peroxisome_Homo sapiens_hsa041461.15576805
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15109473
36SNARE interactions in vesicular transport_Homo sapiens_hsa041301.14573342
37Oxidative phosphorylation_Homo sapiens_hsa001901.12657890
38Glucagon signaling pathway_Homo sapiens_hsa049221.12247102
39cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12122053
40Renin secretion_Homo sapiens_hsa049241.11687448
41Vibrio cholerae infection_Homo sapiens_hsa051101.08421699
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.02436628
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.01109533
44Dilated cardiomyopathy_Homo sapiens_hsa054140.96553169
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95481640
46Collecting duct acid secretion_Homo sapiens_hsa049660.93667601
47Pancreatic secretion_Homo sapiens_hsa049720.92238894
48cAMP signaling pathway_Homo sapiens_hsa040240.92107337
49Calcium signaling pathway_Homo sapiens_hsa040200.90313808
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88501402
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87897193
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.86523916
53Type I diabetes mellitus_Homo sapiens_hsa049400.84853763
54Insulin resistance_Homo sapiens_hsa049310.83862125
55beta-Alanine metabolism_Homo sapiens_hsa004100.82591295
56Salivary secretion_Homo sapiens_hsa049700.81961760
57Lysine degradation_Homo sapiens_hsa003100.81816071
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.81179137
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79979359
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.79383970
61Thyroid hormone synthesis_Homo sapiens_hsa049180.78750468
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78235075
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77806946
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75731663
65Sphingolipid metabolism_Homo sapiens_hsa006000.75051115
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.74126558
67Folate biosynthesis_Homo sapiens_hsa007900.73600607
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.72733190
69Gastric acid secretion_Homo sapiens_hsa049710.71629446
70N-Glycan biosynthesis_Homo sapiens_hsa005100.68003316
71Inositol phosphate metabolism_Homo sapiens_hsa005620.66897422
72Regulation of autophagy_Homo sapiens_hsa041400.64813469
73Oxytocin signaling pathway_Homo sapiens_hsa049210.63427203
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58656962
75Galactose metabolism_Homo sapiens_hsa000520.55064241
76GnRH signaling pathway_Homo sapiens_hsa049120.54732388
77Nitrogen metabolism_Homo sapiens_hsa009100.53642165
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53578743
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53048400
80Starch and sucrose metabolism_Homo sapiens_hsa005000.52691524
81Butanoate metabolism_Homo sapiens_hsa006500.51982475
82Long-term depression_Homo sapiens_hsa047300.51865090
83Insulin signaling pathway_Homo sapiens_hsa049100.51394789
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51151927
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51086462
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50733552
87* AMPK signaling pathway_Homo sapiens_hsa041520.50205407
88Steroid biosynthesis_Homo sapiens_hsa001000.49669911
89Ether lipid metabolism_Homo sapiens_hsa005650.49549576
90Prolactin signaling pathway_Homo sapiens_hsa049170.47424771
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47350929
92Estrogen signaling pathway_Homo sapiens_hsa049150.46487443
93Lysosome_Homo sapiens_hsa041420.44899142
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.44742290
95Fatty acid degradation_Homo sapiens_hsa000710.43218357
96Metabolic pathways_Homo sapiens_hsa011000.43031957
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41116619
98Tryptophan metabolism_Homo sapiens_hsa003800.41116539
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41009162
100Ovarian steroidogenesis_Homo sapiens_hsa049130.40668364
101Retinol metabolism_Homo sapiens_hsa008300.40650887
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40524699
103Cardiac muscle contraction_Homo sapiens_hsa042600.40082388
104Mineral absorption_Homo sapiens_hsa049780.39921030
105Dorso-ventral axis formation_Homo sapiens_hsa043200.39392034
106Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39201001
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39161461
108ErbB signaling pathway_Homo sapiens_hsa040120.38058503
109Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36771101
110MAPK signaling pathway_Homo sapiens_hsa040100.36018141
111Phenylalanine metabolism_Homo sapiens_hsa003600.35209413
112Endometrial cancer_Homo sapiens_hsa052130.35107162
113* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34127150
114Melanogenesis_Homo sapiens_hsa049160.33562097
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33428132
116Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33313573
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.33306025
118Histidine metabolism_Homo sapiens_hsa003400.32953498
119Oocyte meiosis_Homo sapiens_hsa041140.32556266
120mTOR signaling pathway_Homo sapiens_hsa041500.32279433
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30710975
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30048550
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.28737815
124Non-homologous end-joining_Homo sapiens_hsa034500.28726056
125Alzheimers disease_Homo sapiens_hsa050100.28188164
126Selenocompound metabolism_Homo sapiens_hsa004500.28113186
127Linoleic acid metabolism_Homo sapiens_hsa005910.27984992
128Propanoate metabolism_Homo sapiens_hsa006400.26924058
129FoxO signaling pathway_Homo sapiens_hsa040680.26492248
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.26342619
131Chemical carcinogenesis_Homo sapiens_hsa052040.25900544
132Bile secretion_Homo sapiens_hsa049760.25552322
133One carbon pool by folate_Homo sapiens_hsa006700.24785402
134Steroid hormone biosynthesis_Homo sapiens_hsa001400.23772586
135Arginine and proline metabolism_Homo sapiens_hsa003300.23555890
136Fatty acid biosynthesis_Homo sapiens_hsa000610.22820472
137Pyruvate metabolism_Homo sapiens_hsa006200.21347867

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