PFKFB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)6.73082238
2growth hormone receptor signaling pathway (GO:0060396)5.60214740
3NIK/NF-kappaB signaling (GO:0038061)5.39371130
4regulation of vitamin D biosynthetic process (GO:0060556)5.36785835
5regulation of sequestering of triglyceride (GO:0010889)5.12273637
6cellular response to growth hormone stimulus (GO:0071378)4.80766228
7negative regulation of interleukin-12 production (GO:0032695)4.72814916
8response to peptidoglycan (GO:0032494)4.71919858
9brown fat cell differentiation (GO:0050873)4.61719144
10white fat cell differentiation (GO:0050872)4.59636130
11regulation of fever generation (GO:0031620)4.58753019
12valine metabolic process (GO:0006573)4.51621622
13regulation of cholesterol storage (GO:0010885)4.42097045
14regulation of vitamin metabolic process (GO:0030656)4.27509006
15triglyceride catabolic process (GO:0019433)4.17914392
16negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.17087526
17negative regulation of granulocyte differentiation (GO:0030853)4.16536018
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.13172813
19biotin metabolic process (GO:0006768)4.12268634
20positive regulation of membrane protein ectodomain proteolysis (GO:0051044)4.12126642
21lipopolysaccharide-mediated signaling pathway (GO:0031663)4.04189633
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.03058924
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.03058924
24positive regulation of chemokine biosynthetic process (GO:0045080)3.95992434
25antigen processing and presentation of endogenous antigen (GO:0019883)3.92241072
26regulation of T-helper 1 cell differentiation (GO:0045625)3.81698916
27fatty acid transmembrane transport (GO:1902001)3.79899403
28regulation of membrane protein ectodomain proteolysis (GO:0051043)3.78539693
29germinal center formation (GO:0002467)3.75859123
30response to dietary excess (GO:0002021)3.72813410
31regulation of cytokine secretion involved in immune response (GO:0002739)3.71545684
32regulation of podosome assembly (GO:0071801)3.68298738
33lipid storage (GO:0019915)3.67078454
34acylglycerol catabolic process (GO:0046464)3.65971767
35neutral lipid catabolic process (GO:0046461)3.65971767
36regulation of chronic inflammatory response (GO:0002676)3.64108507
37negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.60759876
38T-helper 1 type immune response (GO:0042088)3.60571867
39branching involved in labyrinthine layer morphogenesis (GO:0060670)3.58113087
40regulation of chemokine biosynthetic process (GO:0045073)3.57646642
41positive regulation of macrophage cytokine production (GO:0060907)3.56871225
42carnitine shuttle (GO:0006853)3.56703804
43negative regulation of lipid storage (GO:0010888)3.56350439
44positive regulation of histone deacetylation (GO:0031065)3.54674915
45regulation of mononuclear cell migration (GO:0071675)3.50117608
46negative regulation of phagocytosis (GO:0050765)3.47436546
47negative regulation of cytokine production involved in immune response (GO:0002719)3.46185136
48positive regulation of heat generation (GO:0031652)3.40534901
49positive regulation of fatty acid beta-oxidation (GO:0032000)3.38091763
50adaptation of signaling pathway (GO:0023058)3.35739226
51negative regulation of protein autophosphorylation (GO:0031953)3.34996416
52positive regulation of cholesterol efflux (GO:0010875)3.31430975
53JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.30019710
54tyrosine phosphorylation of STAT protein (GO:0007260)3.29772880
55regulation of T-helper 2 cell differentiation (GO:0045628)3.27370950
56positive regulation of p38MAPK cascade (GO:1900745)3.24732341
57regulation of interferon-alpha production (GO:0032647)3.22762130
58type I interferon signaling pathway (GO:0060337)3.18386641
59cellular response to type I interferon (GO:0071357)3.18386641
60response to muramyl dipeptide (GO:0032495)3.14866067
61response to type I interferon (GO:0034340)3.14624699
62triglyceride biosynthetic process (GO:0019432)3.09832290
63serine transport (GO:0032329)3.08376350
64positive regulation of type 2 immune response (GO:0002830)3.07183303
65positive regulation of sterol transport (GO:0032373)3.07045105
66positive regulation of cholesterol transport (GO:0032376)3.07045105
67regulation of nitric oxide biosynthetic process (GO:0045428)3.06607428
68positive regulation of lipid storage (GO:0010884)3.06128326
69regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.05908537
70positive regulation of acute inflammatory response (GO:0002675)3.05663174
71positive regulation of nitric oxide biosynthetic process (GO:0045429)3.05619862
72regulation of heterotypic cell-cell adhesion (GO:0034114)3.04314288
73positive regulation of fatty acid oxidation (GO:0046321)3.03824215
74activation of MAPKKK activity (GO:0000185)3.03209196
75positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.02853580
76detection of molecule of bacterial origin (GO:0032490)3.02567614
77negative regulation of nitric oxide biosynthetic process (GO:0045019)2.98974258
78cellular response to lipopolysaccharide (GO:0071222)2.97525869
79regulation of macrophage derived foam cell differentiation (GO:0010743)2.95337162
80positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.95095342
81positive regulation of NF-kappaB import into nucleus (GO:0042346)2.93320967
82response to protozoan (GO:0001562)2.93254853
83defense response to protozoan (GO:0042832)2.92588200
84regulation of interleukin-12 biosynthetic process (GO:0045075)2.92032391
85positive regulation of cellular amide metabolic process (GO:0034250)2.91818579
86regulation of interleukin-8 biosynthetic process (GO:0045414)2.91679078
87positive regulation of natural killer cell differentiation (GO:0032825)2.91116077
88cellular response to molecule of bacterial origin (GO:0071219)2.89922832
89neutral lipid biosynthetic process (GO:0046460)2.89706873
90acylglycerol biosynthetic process (GO:0046463)2.89706873
91negative regulation of production of molecular mediator of immune response (GO:0002701)2.89477990
92lipid particle organization (GO:0034389)2.87903100
93skeletal muscle adaptation (GO:0043501)2.86321052
94neutrophil activation involved in immune response (GO:0002283)2.85348613
95immunoglobulin mediated immune response (GO:0016064)2.84536812
96negative regulation of erythrocyte differentiation (GO:0045647)2.84373605
97positive regulation of gamma-delta T cell activation (GO:0046645)2.84154819
98interferon-gamma-mediated signaling pathway (GO:0060333)2.83746090
99positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.83393671
100carnitine transmembrane transport (GO:1902603)2.83312052
101regulation of dendritic cell antigen processing and presentation (GO:0002604)2.82984346
102negative regulation of amino acid transport (GO:0051956)2.82005496
103myeloid dendritic cell differentiation (GO:0043011)2.80241398
104negative regulation of innate immune response (GO:0045824)2.79390000
105macrophage activation (GO:0042116)2.79266030
106regulation of lipid storage (GO:0010883)2.77439786
107negative regulation of systemic arterial blood pressure (GO:0003085)2.77281143
108ovulation from ovarian follicle (GO:0001542)2.76929809
109monocyte chemotaxis (GO:0002548)2.76338147
110macrophage activation involved in immune response (GO:0002281)2.74485699
111regulation of type 2 immune response (GO:0002828)2.73462850
112intracellular lipid transport (GO:0032365)2.72779160
113L-serine transport (GO:0015825)2.69964516
114negative regulation of macrophage differentiation (GO:0045650)2.69669004
115positive regulation of antigen processing and presentation (GO:0002579)2.69122518
116regulation of necroptotic process (GO:0060544)2.68147259
117cellular response to thyroid hormone stimulus (GO:0097067)2.67281408
118regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.66498829
119positive regulation of interleukin-6 production (GO:0032755)2.66238087
120pentose-phosphate shunt (GO:0006098)2.65793720
121glycerolipid catabolic process (GO:0046503)2.65680483
122natural killer cell mediated immunity (GO:0002228)2.64329592
123natural killer cell mediated cytotoxicity (GO:0042267)2.64329592
124regulation of interleukin-12 production (GO:0032655)2.64234489
125regulation of heat generation (GO:0031650)2.63866661
126positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.63649818
127regulation of p38MAPK cascade (GO:1900744)2.63433659
128positive regulation of protein deacetylation (GO:0090312)2.63245781
129positive regulation of interferon-alpha production (GO:0032727)2.62172733
130regulation of macrophage cytokine production (GO:0010935)2.61535033
131regulation of NF-kappaB import into nucleus (GO:0042345)2.61146759
132detection of other organism (GO:0098543)2.60795807
133negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.60755150
134regulation of interferon-beta biosynthetic process (GO:0045357)2.60239426
135granulocyte activation (GO:0036230)2.60145421
136regulation of type I interferon-mediated signaling pathway (GO:0060338)2.60026519
137regulation of macrophage chemotaxis (GO:0010758)2.59940048
138regulation of fatty acid beta-oxidation (GO:0031998)2.59253545
139adhesion of symbiont to host cell (GO:0044650)2.58583234
140virion attachment to host cell (GO:0019062)2.58583234
141cellular response to lithium ion (GO:0071285)2.58287135
142negative regulation of necroptotic process (GO:0060546)2.56423907
143response to manganese ion (GO:0010042)2.55806520
144regulation of T cell tolerance induction (GO:0002664)2.55671416
145modulation of growth of symbiont involved in interaction with host (GO:0044144)2.54048961
146regulation of growth of symbiont in host (GO:0044126)2.54048961
147negative regulation of growth of symbiont in host (GO:0044130)2.54048961
148negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.54048961
149cellular response to biotic stimulus (GO:0071216)2.52903045
150dendritic cell differentiation (GO:0097028)2.52782079
151NADPH regeneration (GO:0006740)2.52180490
152glycosphingolipid catabolic process (GO:0046479)2.51898369
153carnitine transport (GO:0015879)2.51710570
154amino-acid betaine transport (GO:0015838)2.51710570
155regulation of RIG-I signaling pathway (GO:0039535)2.51379411
156protein localization to endosome (GO:0036010)2.50855897
157negative regulation of cell killing (GO:0031342)2.50532047
158negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.50532047
159positive regulation of cellular response to insulin stimulus (GO:1900078)2.50476676
160positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.49417993
161regulation of gamma-delta T cell activation (GO:0046643)2.49358193
162regulation of immunoglobulin secretion (GO:0051023)2.47604756
163response to lipoprotein particle (GO:0055094)2.47532794
164retina vasculature morphogenesis in camera-type eye (GO:0061299)2.46859468
165positive regulation by symbiont of host defense response (GO:0052509)2.45391523
166modulation by symbiont of host defense response (GO:0052031)2.45391523
167modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.45391523
168modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.45391523
169positive regulation by organism of defense response of other organism involved in symbiotic interact2.45391523
170modulation by symbiont of host immune response (GO:0052553)2.45391523
171cortical actin cytoskeleton organization (GO:0030866)2.44353119
172positive regulation of lipid catabolic process (GO:0050996)2.43052592
173regulation of fatty acid oxidation (GO:0046320)2.42654952
174plasma lipoprotein particle clearance (GO:0034381)2.41568712
175regulation of response to interferon-gamma (GO:0060330)2.39571052
176positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.38380828

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.83966909
2STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse4.01220029
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.73020383
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.60434762
5* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.08584465
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.05000505
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.83009972
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.71358549
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.61116292
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.57813497
11* CLOCK_20551151_ChIP-Seq_293T_Human2.45568482
12* IRF8_27001747_Chip-Seq_BMDM_Mouse2.35888975
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.34702580
14GATA1_22025678_ChIP-Seq_K562_Human2.21300171
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.20791748
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.12355496
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.07787426
18* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.04901894
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.02384601
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.02211530
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.00373083
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.96220990
23* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.90395899
24VDR_24787735_ChIP-Seq_THP-1_Human1.88663360
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.85620292
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.71050653
27* RUNX_20019798_ChIP-Seq_JUKART_Human1.70324688
28TCF7_22412390_ChIP-Seq_EML_Mouse1.69297183
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.67991371
30PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.62450668
31VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.62095102
32FOXO3_23340844_ChIP-Seq_DLD1_Human1.59597325
33* KDM2B_26808549_Chip-Seq_DND41_Human1.58801009
34TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57336867
35NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.56720564
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.56118864
37LXR_22292898_ChIP-Seq_THP-1_Human1.54468821
38SPI1_23127762_ChIP-Seq_K562_Human1.52051380
39VDR_21846776_ChIP-Seq_THP-1_Human1.48106216
40FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.47415610
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.47028582
42* MAF_26560356_Chip-Seq_TH1_Human1.42794626
43MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.42650445
44* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.42577228
45* ELK3_25401928_ChIP-Seq_HUVEC_Human1.41970647
46THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41384557
47* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.41363166
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40151200
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.37445591
50SCL_19346495_ChIP-Seq_HPC-7_Human1.37368027
51PPAR_26484153_Chip-Seq_NCI-H1993_Human1.35017205
52VDR_24763502_ChIP-Seq_THP-1_Human1.32008284
53FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.31658599
54* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.30989133
55* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.29646220
56TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29117583
57* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.28531032
58CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.26362306
59* KDM2B_26808549_Chip-Seq_K562_Human1.26167696
60PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23904103
61* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21426404
62* ESR2_21235772_ChIP-Seq_MCF-7_Human1.20284279
63GATA1_19941827_ChIP-Seq_MEL_Mouse1.18477924
64MYC_22102868_ChIP-Seq_BL_Human1.16151477
65MYB_26560356_Chip-Seq_TH2_Human1.13163241
66* LXR_22158963_ChIP-Seq_LIVER_Mouse1.12093914
67* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11436862
68PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11348470
69* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11065643
70SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10913736
71GATA1_19941826_ChIP-Seq_K562_Human1.10203238
72NFIB_24661679_ChIP-Seq_LUNG_Mouse1.10123033
73STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10093377
74CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08232459
75PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.07634568
76* RACK7_27058665_Chip-Seq_MCF-7_Human1.06860749
77NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05548668
78* KDM2B_26808549_Chip-Seq_JURKAT_Human1.05407420
79RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04212436
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04168285
81MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03855861
82GATA3_27048872_Chip-Seq_THYMUS_Human1.03649097
83MYB_26560356_Chip-Seq_TH1_Human1.03372608
84* TBX20_22080862_ChIP-Seq_HEART_Mouse1.02362605
85* TBX20_22328084_ChIP-Seq_HEART_Mouse1.02362605
86MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01046681
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00913688
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98241300
89GATA2_19941826_ChIP-Seq_K562_Human0.95477360
90KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.95247636
91KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.95247636
92KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.95247636
93EGR1_19032775_ChIP-ChIP_M12_Human0.94901630
94ESR1_21235772_ChIP-Seq_MCF-7_Human0.93527224
95PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93064512
96TRIM28_21343339_ChIP-Seq_HEK293_Human0.93012399
97CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92303057
98* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92125112
99ZNF263_19887448_ChIP-Seq_K562_Human0.91624333
100SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91249301
101LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91191482
102RXR_22158963_ChIP-Seq_LIVER_Mouse0.91090512
103UTX_26944678_Chip-Seq_JUKART_Human0.89757175
104STAT4_19710469_ChIP-ChIP_TH1__Mouse0.89658924
105SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89487181
106FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.89483244
107DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88627767
108SPI1_23547873_ChIP-Seq_NB4_Human0.88485646
109RXR_22108803_ChIP-Seq_LS180_Human0.87879964
110RUNX1_22412390_ChIP-Seq_EML_Mouse0.87803174
111WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.86947809
112* UBF1/2_26484160_Chip-Seq_HMECs_Human0.86420938
113GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85944874
114JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85849713
115PPARA_22158963_ChIP-Seq_LIVER_Mouse0.85813411
116* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.83812905
117* MAF_26560356_Chip-Seq_TH2_Human0.82727718
118STAT6_21828071_ChIP-Seq_BEAS2B_Human0.82554800
119CDX2_19796622_ChIP-Seq_MESCs_Mouse0.82344340
120* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.82248688
121JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81471850
122PU_27001747_Chip-Seq_BMDM_Mouse0.81285651
123CDX2_20551321_ChIP-Seq_CACO-2_Human0.81285490
124CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81209714
125BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80831601
126ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80760602

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose5.25290559
2MP0002254_reproductive_system_inflammat4.76330591
3MP0005666_abnormal_adipose_tissue3.97482395
4MP0004185_abnormal_adipocyte_glucose3.76874354
5MP0004130_abnormal_muscle_cell3.55696646
6MP0005375_adipose_tissue_phenotype2.76701039
7MP0002166_altered_tumor_susceptibility2.49322848
8MP0002971_abnormal_brown_adipose2.47504102
9MP0003191_abnormal_cellular_cholesterol2.38087005
10MP0002138_abnormal_hepatobiliary_system2.36765292
11MP0001835_abnormal_antigen_presentation2.32525292
12MP0009840_abnormal_foam_cell2.32061145
13MP0009115_abnormal_fat_cell2.29188370
14MP0004510_myositis2.16259799
15MP0008004_abnormal_stomach_pH2.12371834
16MP0003303_peritoneal_inflammation2.04023114
17MP0003724_increased_susceptibility_to2.01106445
18MP0003705_abnormal_hypodermis_morpholog2.00044051
19MP0008438_abnormal_cutaneous_collagen1.99245679
20MP0005451_abnormal_body_composition1.98499037
21MP0003436_decreased_susceptibility_to1.96996019
22MP0000685_abnormal_immune_system1.93280885
23MP0002006_tumorigenesis1.89431351
24MP0001790_abnormal_immune_system1.83696062
25MP0005387_immune_system_phenotype1.83696062
26MP0005334_abnormal_fat_pad1.82462701
27MP0002009_preneoplasia1.77550820
28MP0004858_abnormal_nervous_system1.69858632
29MP0000569_abnormal_digit_pigmentation1.67505398
30MP0002139_abnormal_hepatobiliary_system1.60078085
31MP0002970_abnormal_white_adipose1.58840576
32MP0001800_abnormal_humoral_immune1.50930071
33MP0000003_abnormal_adipose_tissue1.47423535
34MP0005166_decreased_susceptibility_to1.47349543
35MP0005000_abnormal_immune_tolerance1.46872373
36MP0002419_abnormal_innate_immunity1.46754997
37MP0010155_abnormal_intestine_physiology1.45146117
38MP0003045_fibrosis1.43527627
39MP0001348_abnormal_lacrimal_gland1.41269643
40MP0010329_abnormal_lipoprotein_level1.40568347
41MP0002452_abnormal_antigen_presenting1.40252068
42MP0003828_pulmonary_edema1.37510932
43MP0009785_altered_susceptibility_to1.36673491
44MP0003300_gastrointestinal_ulcer1.36433414
45MP0000013_abnormal_adipose_tissue1.35756067
46MP0001533_abnormal_skeleton_physiology1.35586678
47MP0003448_altered_tumor_morphology1.35282524
48MP0002332_abnormal_exercise_endurance1.35247694
49MP0008961_abnormal_basal_metabolism1.34250354
50MP0000858_altered_metastatic_potential1.32193956
51MP0005076_abnormal_cell_differentiation1.31428871
52MP0003690_abnormal_glial_cell1.30944070
53MP0001881_abnormal_mammary_gland1.30842593
54MP0001853_heart_inflammation1.30107643
55MP0002277_abnormal_respiratory_mucosa1.27123032
56MP0002723_abnormal_immune_serum1.26270418
57MP0002876_abnormal_thyroid_physiology1.24680535
58MP0005535_abnormal_body_temperature1.24390640
59MP0010352_gastrointestinal_tract_polyps1.22000151
60MP0001819_abnormal_immune_cell1.21248633
61MP0000343_altered_response_to1.20759105
62MP0005025_abnormal_response_to1.19126121
63MP0002420_abnormal_adaptive_immunity1.18689451
64MP0005058_abnormal_lysosome_morphology1.18554543
65MP0003329_amyloid_beta_deposits1.17646595
66MP0000609_abnormal_liver_physiology1.16643319
67MP0003566_abnormal_cell_adhesion1.15788536
68MP0005671_abnormal_response_to1.15371991
69MP0005275_abnormal_skin_tensile1.15222066
70MP0002148_abnormal_hypersensitivity_rea1.14201505
71MP0002998_abnormal_bone_remodeling1.14126564
72MP0003091_abnormal_cell_migration1.13866402
73MP0002118_abnormal_lipid_homeostasis1.11633838
74MP0000604_amyloidosis1.10094916
75MP0005023_abnormal_wound_healing1.10094234
76MP0006054_spinal_hemorrhage1.08681846
77MP0005310_abnormal_salivary_gland1.07366063
78MP0004947_skin_inflammation1.05914239
79MP0001542_abnormal_bone_strength1.04481461
80MP0001501_abnormal_sleep_pattern1.02263286
81MP0006082_CNS_inflammation1.01827365
82MP0000920_abnormal_myelination1.01699359
83MP0005390_skeleton_phenotype1.01601013
84MP0005448_abnormal_energy_balance1.00756623
85MP0003656_abnormal_erythrocyte_physiolo0.99473970
86MP0000249_abnormal_blood_vessel0.98708790
87MP0005464_abnormal_platelet_physiology0.97149914
88MP0002396_abnormal_hematopoietic_system0.96756978
89MP0001879_abnormal_lymphatic_vessel0.96312266
90MP0000750_abnormal_muscle_regeneration0.95097207
91MP0003195_calcinosis0.94991631
92MP0008775_abnormal_heart_ventricle0.94750424
93MP0005165_increased_susceptibility_to0.94568180
94MP0002837_dystrophic_cardiac_calcinosis0.93273695
95MP0005167_abnormal_blood-brain_barrier0.90872602
96MP0005164_abnormal_response_to0.90730517
97MP0009333_abnormal_splenocyte_physiolog0.90409805
98MP0008260_abnormal_autophagy0.90395728
99MP0005452_abnormal_adipose_tissue0.89890604
100MP0003183_abnormal_peptide_metabolism0.88964782
101MP0001851_eye_inflammation0.88792018
102MP0003075_altered_response_to0.88788230
103MP0000716_abnormal_immune_system0.87561281
104MP0004087_abnormal_muscle_fiber0.86951516
105MP0003959_abnormal_lean_body0.86278625
106MP0003646_muscle_fatigue0.86213146
107MP0005397_hematopoietic_system_phenotyp0.86150500
108MP0001545_abnormal_hematopoietic_system0.86150500
109MP0003172_abnormal_lysosome_physiology0.85943915
110MP0002933_joint_inflammation0.85879194
111MP0003279_aneurysm0.85115278
112MP0001873_stomach_inflammation0.84784008
113MP0002405_respiratory_system_inflammati0.84728222
114MP0004883_abnormal_blood_vessel0.84535969
115MP0000733_abnormal_muscle_development0.84528562
116MP0009763_increased_sensitivity_to0.84383246
117MP0000759_abnormal_skeletal_muscle0.84228758
118MP0003453_abnormal_keratinocyte_physiol0.83877029
119MP0002877_abnormal_melanocyte_morpholog0.83867164
120MP0009278_abnormal_bone_marrow0.79475904
121MP0005595_abnormal_vascular_smooth0.78898196
122MP0008469_abnormal_protein_level0.78812730
123MP0008874_decreased_physiological_sensi0.76342283
124MP0001845_abnormal_inflammatory_respons0.76195071
125MP0002398_abnormal_bone_marrow0.75231432
126MP0009764_decreased_sensitivity_to0.73624451
127MP0003634_abnormal_glial_cell0.71572152
128MP0009765_abnormal_xenobiotic_induced0.69807590
129MP0001663_abnormal_digestive_system0.69057218
130MP0005647_abnormal_sex_gland0.67393087
131MP0003795_abnormal_bone_structure0.66294154
132MP0001849_ear_inflammation0.66076039

Predicted human phenotypes

RankGene SetZ-score
1Difficulty running (HP:0009046)5.28651960
2Oligomenorrhea (HP:0000876)4.87827572
3Acanthosis nigricans (HP:0000956)4.18930821
4Neurofibrillary tangles (HP:0002185)4.13254557
5Myocardial infarction (HP:0001658)4.06795209
6Hypertriglyceridemia (HP:0002155)3.97299436
7Dysostosis multiplex (HP:0000943)3.81837711
8Hydroxyprolinuria (HP:0003080)3.74612286
9Abnormality of proline metabolism (HP:0010907)3.74612286
10Loss of speech (HP:0002371)3.67441174
11Nuclear cataract (HP:0100018)3.60597450
12Disinhibition (HP:0000734)3.48031710
13Mutism (HP:0002300)3.47135673
14Stomatitis (HP:0010280)3.46855926
15Fatigue (HP:0012378)3.40066822
16Glomerulonephritis (HP:0000099)3.39850141
17Keratoconjunctivitis sicca (HP:0001097)3.39784995
18Vacuolated lymphocytes (HP:0001922)3.38951528
19Hematochezia (HP:0002573)3.34175349
20Autoimmune thrombocytopenia (HP:0001973)3.32633999
21Increased connective tissue (HP:0009025)3.31130273
22Axonal loss (HP:0003447)3.23998449
23Cerebral inclusion bodies (HP:0100314)3.16703140
24Interstitial pulmonary disease (HP:0006530)3.15494004
25Complement deficiency (HP:0004431)3.14147260
26Systemic lupus erythematosus (HP:0002725)3.11938777
27Tetraparesis (HP:0002273)3.10551873
28Nasal polyposis (HP:0100582)3.08500035
29Eczematoid dermatitis (HP:0000976)3.07334453
30Myoglobinuria (HP:0002913)3.05714716
31Keratoconjunctivitis (HP:0001096)3.02182728
32Abnormality of the nasal mucosa (HP:0000433)2.98741932
33Orchitis (HP:0100796)2.88424128
34Abnormality of mucopolysaccharide metabolism (HP:0011020)2.88175715
35Abnormality of polysaccharide metabolism (HP:0011012)2.88175715
36Abnormality of glycosaminoglycan metabolism (HP:0004371)2.88175715
37Polycythemia (HP:0001901)2.81876665
38Increased neuronal autofluorescent lipopigment (HP:0002074)2.80171309
39Hyperglycinuria (HP:0003108)2.79974794
40Cerebral aneurysm (HP:0004944)2.79378854
41Recurrent viral infections (HP:0004429)2.77940253
42Hyporeflexia of lower limbs (HP:0002600)2.77761276
43Mucopolysacchariduria (HP:0008155)2.75768547
44Urinary glycosaminoglycan excretion (HP:0003541)2.75768547
45Colitis (HP:0002583)2.74565768
46Apathy (HP:0000741)2.74270344
47Reduced subcutaneous adipose tissue (HP:0003758)2.73801390
48Recurrent fungal infections (HP:0002841)2.73552858
49Cortical dysplasia (HP:0002539)2.72486257
50Neuronal loss in central nervous system (HP:0002529)2.66570729
51Insulin-resistant diabetes mellitus (HP:0000831)2.66518880
52Myositis (HP:0100614)2.65327547
53Peritonitis (HP:0002586)2.64712102
54Osteolytic defects of the phalanges of the hand (HP:0009771)2.62861456
55Osteolytic defects of the hand bones (HP:0009699)2.62861456
56Diminished motivation (HP:0000745)2.58843915
57Recurrent abscess formation (HP:0002722)2.56785054
58Recurrent bacterial skin infections (HP:0005406)2.53516554
59Frequent falls (HP:0002359)2.52633282
60Chronic otitis media (HP:0000389)2.47839583
61Increased IgE level (HP:0003212)2.47832341
62Multiple enchondromatosis (HP:0005701)2.46048446
63Gangrene (HP:0100758)2.45106672
64Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.44202817
65Exercise-induced myalgia (HP:0003738)2.43657769
66Hemorrhage of the eye (HP:0011885)2.42988326
67Segmental peripheral demyelination/remyelination (HP:0003481)2.42264225
68Pigmentary retinal degeneration (HP:0001146)2.41278388
69Facial diplegia (HP:0001349)2.40882935
70Type 1 muscle fiber predominance (HP:0003803)2.37543446
71Muscle fiber splitting (HP:0003555)2.33971007
72Increased serum ferritin (HP:0003281)2.30972927
73Parakeratosis (HP:0001036)2.28784084
74Elevated erythrocyte sedimentation rate (HP:0003565)2.26979709
75Gingivitis (HP:0000230)2.26065199
76Pulmonary infiltrates (HP:0002113)2.25900546
77Rhabdomyolysis (HP:0003201)2.24156052
78Exercise-induced muscle cramps (HP:0003710)2.24147404
79Muscle stiffness (HP:0003552)2.22705311
80Abnormality of complement system (HP:0005339)2.22094576
81Hemoptysis (HP:0002105)2.19912735
82Asymmetric septal hypertrophy (HP:0001670)2.18192925
83Amyloidosis (HP:0011034)2.17150149
84Thin bony cortex (HP:0002753)2.13457922
85Increased variability in muscle fiber diameter (HP:0003557)2.09624540
86Chest pain (HP:0100749)2.09254443
87Supranuclear gaze palsy (HP:0000605)2.09136067
88Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.06650821
89Hand muscle atrophy (HP:0009130)2.05523160
90Increased cerebral lipofuscin (HP:0011813)2.04116856
91Inflammation of the large intestine (HP:0002037)2.01553463
92Polygenic inheritance (HP:0010982)1.96771957
93Polyneuropathy (HP:0001271)1.96588145
94Abnormality of skeletal muscle fiber size (HP:0012084)1.96112237
95Macroorchidism (HP:0000053)1.95651144
96Long foot (HP:0001833)1.94386495
97Retrobulbar optic neuritis (HP:0100654)1.93732237
98Optic neuritis (HP:0100653)1.93732237
99Abnormality of the periventricular white matter (HP:0002518)1.93203687
100Abnormality of glycolipid metabolism (HP:0010969)1.93014754
101Abnormality of liposaccharide metabolism (HP:0010968)1.93014754
102Abnormality of glycosphingolipid metabolism (HP:0004343)1.93014754
103Vertigo (HP:0002321)1.92976714
104Subcapsular cataract (HP:0000523)1.92841003
105Esophageal varix (HP:0002040)1.91726971
106Aortic aneurysm (HP:0004942)1.91635789
107Abnormality of the vasculature of the conjunctiva (HP:0008054)1.91295671
108Purpura (HP:0000979)1.91077523
109Inappropriate behavior (HP:0000719)1.90593906
110Recurrent gram-negative bacterial infections (HP:0005420)1.90495773
111Cellulitis (HP:0100658)1.90161097
112Peripheral demyelination (HP:0011096)1.90124578
113Abnormality of glycine metabolism (HP:0010895)1.89931515
114Abnormality of serine family amino acid metabolism (HP:0010894)1.89931515
115Skin nodule (HP:0200036)1.88595604
116Spondylolisthesis (HP:0003302)1.88362969
117Cerebral hemorrhage (HP:0001342)1.88004175
118Round ear (HP:0100830)1.87657213
119Eosinophilia (HP:0001880)1.87630567
120Abnormality of the fingertips (HP:0001211)1.87506139
121Progressive neurologic deterioration (HP:0002344)1.86854089
122Dementia (HP:0000726)1.86689429
123Nephritis (HP:0000123)1.86415692
124Periodontitis (HP:0000704)1.86258458
125Distal upper limb amyotrophy (HP:0007149)1.86136869
126Upper limb amyotrophy (HP:0009129)1.86136869
127Hyperkalemia (HP:0002153)1.85512585
128Increased IgM level (HP:0003496)1.84849196
129Gastrointestinal inflammation (HP:0004386)1.83156016
130Hypergammaglobulinemia (HP:0010702)1.81502451
131Mitral valve prolapse (HP:0001634)1.81402685
132Upper motor neuron abnormality (HP:0002127)1.80515506
133Recurrent skin infections (HP:0001581)1.80505327
134Abnormal delayed hypersensitivity skin test (HP:0002963)1.80228528
135Arterial thrombosis (HP:0004420)1.79369475
136Basal ganglia calcification (HP:0002135)1.78854613
137Episodic fever (HP:0001954)1.78720269
138Broad metatarsal (HP:0001783)1.78380379
139Growth hormone excess (HP:0000845)1.78009058
140Malnutrition (HP:0004395)1.77665395
141Leukocytosis (HP:0001974)1.76649936
142Hyperparathyroidism (HP:0000843)1.76226442
143Visceral angiomatosis (HP:0100761)1.75786165
144Abnormality of iron homeostasis (HP:0011031)1.75632367
145Ulnar deviation of the wrist (HP:0003049)1.75604056
146Vasculitis (HP:0002633)1.73947110
147Acne (HP:0001061)1.73313519
148Abnormality of the endocardium (HP:0004306)1.73272344
149Abnormality of macrophages (HP:0004311)1.73186019
150Mediastinal lymphadenopathy (HP:0100721)1.73112351
151Memory impairment (HP:0002354)1.73111720
152Increased CSF protein (HP:0002922)1.73055373
153Insulin resistance (HP:0000855)1.71903581
154Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.70434483
155Bone pain (HP:0002653)1.70268003
156Vertebral compression fractures (HP:0002953)1.69955572
157Spontaneous hematomas (HP:0007420)1.69444262
158Abnormality of the pleura (HP:0002103)1.68416586
159Venous abnormality (HP:0002624)1.68024019
160Achilles tendon contracture (HP:0001771)1.67957092
161Glomerulopathy (HP:0100820)1.67947515
162Personality changes (HP:0000751)1.67490304
163Hepatosplenomegaly (HP:0001433)1.66450538
164Abnormality of the pericardium (HP:0001697)1.65101191
165Rapidly progressive (HP:0003678)1.64981373
166Thick nail (HP:0001805)1.64899996
167Arthralgia (HP:0002829)1.64461186

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1D4.24840991
2TRIB33.36436695
3CAMK1G3.17165324
4MAP3K143.02991273
5PRPF4B2.89965109
6DDR22.85667121
7TYK22.72721026
8CDK122.68508946
9ERN12.62241558
10TAOK22.54445653
11GRK72.53441742
12MAP3K132.49695781
13SIK12.45201903
14TGFBR22.44623584
15JAK12.35454931
16CSF1R2.30770171
17FGFR32.27046703
18EPHB12.24480174
19RIPK12.10950271
20JAK32.04238431
21NME21.92146844
22IKBKB1.91810406
23MAP3K31.86125889
24TBK11.80716906
25TAOK11.79472609
26CDC42BPA1.68240240
27LATS21.58272775
28FGFR41.57611227
29MAP3K111.57045588
30* PRKAA21.55111940
31TTN1.54584674
32CHUK1.53186755
33GRK61.47331312
34BMPR21.35040623
35PIM21.34708132
36EPHA31.31111506
37MAP3K11.27475422
38IRAK21.27232211
39JAK21.27100840
40GRK51.26299080
41IKBKE1.24770521
42KIT1.23451049
43CSK1.16078098
44PHKG11.13589553
45PHKG21.13589553
46IRAK31.11850543
47BLK1.04503312
48MAP2K31.04318267
49PKN11.04297635
50MAP3K71.00865869
51PTK60.99930287
52ARAF0.99653068
53MAP3K100.99246803
54NEK90.96590162
55STK100.96076912
56SIK20.93887330
57TXK0.93402333
58FLT30.93262615
59CDK90.88641336
60WNK10.86808377
61RET0.85510616
62ABL20.85112983
63CDK60.84944704
64MAPK120.82499455
65MATK0.78694471
66BMX0.78349345
67RIPK40.78325977
68LMTK20.77178783
69GSK3A0.76453550
70MAP4K10.75397137
71ICK0.75149981
72MAP3K90.71441372
73PDK30.70249436
74PDK40.70249436
75INSRR0.69552331
76HCK0.69024673
77MAPK40.67821950
78TYRO30.67517749
79CLK10.66821553
80BCKDK0.66181401
81MTOR0.65790873
82KSR20.65024878
83MOS0.64105886
84MAP3K50.63262177
85LYN0.62155116
86FES0.58911445
87FGFR20.58737637
88IRAK40.58522923
89PDK10.56554416
90SIK30.56272458
91FGR0.56143663
92IRAK10.55910329
93EIF2AK20.55421518
94LCK0.55144968
95STK110.54863875
96PDPK10.54862151
97DMPK0.54273953
98ZAP700.53746431
99MARK20.53075888
100PDGFRA0.51354089
101SYK0.51033121
102MAPK70.50164909
103TESK10.49185448
104MAP3K60.48981248
105PKN20.48574210
106INSR0.48193313
107PDGFRB0.47969869
108* PRKAA10.47655777
109STK30.47556496
110PDK20.47268206
111MST1R0.47161464
112PIK3CA0.46440044
113PTK2B0.46432670
114IGF1R0.46017611
115SGK10.45482194
116ADRBK20.45280810
117HIPK20.45160867
118RPS6KC10.44601021
119RPS6KL10.44601021
120ITK0.43918638
121PRKG20.43682178
122SGK30.43081405
123MAPKAPK20.42706664
124ALK0.42468824
125EPHB20.41634668
126MAP2K60.41396741
127ABL10.40603327
128RPS6KA20.39941824
129DAPK20.39789710
130MAPK110.37486051
131MARK30.36311816
132PAK40.35728898
133PAK20.35235329
134CAMK40.35048834
135EEF2K0.31061429
136RPS6KA60.30188431
137PIM10.29987480
138BTK0.29443954
139FYN0.28260146

Predicted pathways (KEGG)

RankGene SetZ-score
1Regulation of lipolysis in adipocytes_Homo sapiens_hsa049233.50631802
2Fatty acid biosynthesis_Homo sapiens_hsa000612.81981852
3PPAR signaling pathway_Homo sapiens_hsa033202.45980249
4Adipocytokine signaling pathway_Homo sapiens_hsa049202.38406691
5Other glycan degradation_Homo sapiens_hsa005112.33963780
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.30885429
7Rheumatoid arthritis_Homo sapiens_hsa053232.08905549
8NF-kappa B signaling pathway_Homo sapiens_hsa040641.97096447
9Osteoclast differentiation_Homo sapiens_hsa043801.93987216
10Leishmaniasis_Homo sapiens_hsa051401.87752947
11Staphylococcus aureus infection_Homo sapiens_hsa051501.80138310
12Insulin resistance_Homo sapiens_hsa049311.72298875
13Toxoplasmosis_Homo sapiens_hsa051451.70948969
14Prion diseases_Homo sapiens_hsa050201.59509923
15Propanoate metabolism_Homo sapiens_hsa006401.58221924
16Glycerolipid metabolism_Homo sapiens_hsa005611.56617252
17Asthma_Homo sapiens_hsa053101.54858954
18B cell receptor signaling pathway_Homo sapiens_hsa046621.54080139
19Graft-versus-host disease_Homo sapiens_hsa053321.53026077
20TNF signaling pathway_Homo sapiens_hsa046681.52008245
21* AMPK signaling pathway_Homo sapiens_hsa041521.45993244
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.42782585
23Acute myeloid leukemia_Homo sapiens_hsa052211.41825634
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.33675959
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.31771309
26Fatty acid metabolism_Homo sapiens_hsa012121.29123908
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.27912583
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24584091
29Measles_Homo sapiens_hsa051621.23753485
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23501698
31Apoptosis_Homo sapiens_hsa042101.22303827
32Type II diabetes mellitus_Homo sapiens_hsa049301.22203641
33Insulin signaling pathway_Homo sapiens_hsa049101.21308373
34Small cell lung cancer_Homo sapiens_hsa052221.18861505
35NOD-like receptor signaling pathway_Homo sapiens_hsa046211.15860742
36Bladder cancer_Homo sapiens_hsa052191.14895941
37mTOR signaling pathway_Homo sapiens_hsa041501.12083637
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.07735115
39Chemokine signaling pathway_Homo sapiens_hsa040621.06183560
40Longevity regulating pathway - mammal_Homo sapiens_hsa042111.05384642
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05028160
42Type I diabetes mellitus_Homo sapiens_hsa049401.04746349
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04304660
44Renin secretion_Homo sapiens_hsa049241.04025545
45Pertussis_Homo sapiens_hsa051331.03061145
46Phagosome_Homo sapiens_hsa041451.02642583
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02590319
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02330079
49Tuberculosis_Homo sapiens_hsa051521.01226080
50Chronic myeloid leukemia_Homo sapiens_hsa052201.00048944
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98329230
52Vitamin B6 metabolism_Homo sapiens_hsa007500.97047892
53Influenza A_Homo sapiens_hsa051640.94913842
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.92108960
55Pancreatic cancer_Homo sapiens_hsa052120.88044518
56Hepatitis C_Homo sapiens_hsa051600.87921483
57Viral myocarditis_Homo sapiens_hsa054160.87515462
58Leukocyte transendothelial migration_Homo sapiens_hsa046700.86824764
59VEGF signaling pathway_Homo sapiens_hsa043700.86370770
60Malaria_Homo sapiens_hsa051440.84370648
61T cell receptor signaling pathway_Homo sapiens_hsa046600.84093161
62Caffeine metabolism_Homo sapiens_hsa002320.84001441
63Central carbon metabolism in cancer_Homo sapiens_hsa052300.83972070
64Autoimmune thyroid disease_Homo sapiens_hsa053200.83532733
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.82663574
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82039613
67Legionellosis_Homo sapiens_hsa051340.81433340
68Fatty acid degradation_Homo sapiens_hsa000710.80984011
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.80672944
70Prolactin signaling pathway_Homo sapiens_hsa049170.78966436
71Notch signaling pathway_Homo sapiens_hsa043300.78037758
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77489366
73Antigen processing and presentation_Homo sapiens_hsa046120.76116991
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72756891
75Complement and coagulation cascades_Homo sapiens_hsa046100.71191470
76Platelet activation_Homo sapiens_hsa046110.68710873
77Focal adhesion_Homo sapiens_hsa045100.68269285
78Herpes simplex infection_Homo sapiens_hsa051680.67744171
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67528233
80Lysosome_Homo sapiens_hsa041420.67146140
81* HIF-1 signaling pathway_Homo sapiens_hsa040660.66926489
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.66458211
83Renal cell carcinoma_Homo sapiens_hsa052110.64784354
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.64440106
85Nitrogen metabolism_Homo sapiens_hsa009100.63955873
86Dorso-ventral axis formation_Homo sapiens_hsa043200.63807804
87Hematopoietic cell lineage_Homo sapiens_hsa046400.63555850
88Fat digestion and absorption_Homo sapiens_hsa049750.62844514
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62717106
90Proteoglycans in cancer_Homo sapiens_hsa052050.61979965
91MAPK signaling pathway_Homo sapiens_hsa040100.61090679
92GnRH signaling pathway_Homo sapiens_hsa049120.60718782
93FoxO signaling pathway_Homo sapiens_hsa040680.60417169
94African trypanosomiasis_Homo sapiens_hsa051430.58831394
95Hepatitis B_Homo sapiens_hsa051610.58267342
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58239546
97Amoebiasis_Homo sapiens_hsa051460.57470163
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.57187681
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.55733724
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55691982
1012-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53270073
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52967518
103Glucagon signaling pathway_Homo sapiens_hsa049220.52395167
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51768169
105Sphingolipid metabolism_Homo sapiens_hsa006000.51573634
106Allograft rejection_Homo sapiens_hsa053300.51080185
107Choline metabolism in cancer_Homo sapiens_hsa052310.50323013
108Pathways in cancer_Homo sapiens_hsa052000.49260205
109Non-small cell lung cancer_Homo sapiens_hsa052230.49112812
110Dilated cardiomyopathy_Homo sapiens_hsa054140.48641518
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48385292
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47826544
113Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.47455430
114Salmonella infection_Homo sapiens_hsa051320.47196688
115Oxytocin signaling pathway_Homo sapiens_hsa049210.46961181
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46025828
117Shigellosis_Homo sapiens_hsa051310.45685264
118Epstein-Barr virus infection_Homo sapiens_hsa051690.45155168
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44994422
120Galactose metabolism_Homo sapiens_hsa000520.44900699
121ErbB signaling pathway_Homo sapiens_hsa040120.43536600
122HTLV-I infection_Homo sapiens_hsa051660.42117271
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41165560
124Endocytosis_Homo sapiens_hsa041440.38404909
125Estrogen signaling pathway_Homo sapiens_hsa049150.36659408
126MicroRNAs in cancer_Homo sapiens_hsa052060.32543346
127Rap1 signaling pathway_Homo sapiens_hsa040150.32397452

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