PFKFB4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one of four bifunctional kinase/phosphatases that regulate the concentration of the glycolytic byproduct fructose-2,6-bisphosphate (F2,6BP). The encoded protein is highly expressed in cancer cells and is induced by hypoxia. This protein is essential to the survival of cancer cells under conditions of hypoxia, because it increases the amount of F2,6BP and ATP at a time when the cell cannot produce much of them. This finding suggests that this protein may be a good target for disruption in cancer cells, hopefully imperiling their survival. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glucose 6-phosphate metabolic process (GO:0051156)5.39228402
2leukocyte aggregation (GO:0070486)5.21687261
3neutrophil activation involved in immune response (GO:0002283)5.13252851
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.09167853
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.09167853
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.09167853
7modulation by symbiont of host immune response (GO:0052553)5.09167853
8positive regulation by symbiont of host defense response (GO:0052509)5.09167853
9modulation by symbiont of host defense response (GO:0052031)5.09167853
10plasma lipoprotein particle assembly (GO:0034377)4.79951054
11detection of molecule of bacterial origin (GO:0032490)4.76210999
12regulation of interferon-beta biosynthetic process (GO:0045357)4.68938809
13cellular extravasation (GO:0045123)4.62662954
14detection of external biotic stimulus (GO:0098581)4.58105553
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.51451691
16response to peptidoglycan (GO:0032494)4.48215720
17regulation of B cell receptor signaling pathway (GO:0050855)4.46039824
18positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.32679373
19leukocyte migration involved in inflammatory response (GO:0002523)4.31659157
20very-low-density lipoprotein particle assembly (GO:0034379)4.26498503
21neutrophil mediated immunity (GO:0002446)4.21714222
22respiratory burst (GO:0045730)4.17289033
23histone H3-K9 demethylation (GO:0033169)4.16503011
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.16205653
25positive regulation of mast cell activation (GO:0033005)4.15986141
26protein-lipid complex assembly (GO:0065005)4.14312590
27response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.10009739
28response to host immune response (GO:0052572)4.10009739
29macrophage activation involved in immune response (GO:0002281)4.01356779
30detection of biotic stimulus (GO:0009595)4.01281813
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.99045195
32neutrophil activation (GO:0042119)3.97964746
33response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.95543727
34response to host (GO:0075136)3.95543727
35response to host defenses (GO:0052200)3.95543727
36regulation of mast cell degranulation (GO:0043304)3.86447698
37peptidyl-proline hydroxylation (GO:0019511)3.80872599
38regulation of leukocyte degranulation (GO:0043300)3.75507848
39regulation of mast cell activation (GO:0033003)3.72069053
40negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.71984979
41* glycolytic process (GO:0006096)3.71282598
42defense response to fungus (GO:0050832)3.69329144
434-hydroxyproline metabolic process (GO:0019471)3.65987582
44granulocyte activation (GO:0036230)3.63400014
45microglial cell activation (GO:0001774)3.60601661
46regulation of mast cell activation involved in immune response (GO:0033006)3.60302800
47regulation of myeloid leukocyte mediated immunity (GO:0002886)3.58648473
48response to fungus (GO:0009620)3.53646654
49positive regulation of mast cell degranulation (GO:0043306)3.47891341
50positive regulation of mast cell activation involved in immune response (GO:0033008)3.47891341
51production of molecular mediator involved in inflammatory response (GO:0002532)3.46600850
52Arp2/3 complex-mediated actin nucleation (GO:0034314)3.42568696
53response to interleukin-15 (GO:0070672)3.39920079
54regulation of cellular amide metabolic process (GO:0034248)3.39190626
55negative regulation of cell killing (GO:0031342)3.34350820
56negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.34350820
57negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.29323038
58negative regulation of lymphocyte mediated immunity (GO:0002707)3.28373853
59regulation of regulated secretory pathway (GO:1903305)3.24906402
60immunoglobulin mediated immune response (GO:0016064)3.24718027
61detection of other organism (GO:0098543)3.22548709
62leukotriene metabolic process (GO:0006691)3.21557773
63neutrophil chemotaxis (GO:0030593)3.20856534
64myeloid leukocyte mediated immunity (GO:0002444)3.19802554
65positive regulation of interferon-alpha production (GO:0032727)3.14048529
66angiotensin maturation (GO:0002003)3.11827860
67neutrophil migration (GO:1990266)3.10730611
68negative regulation of interleukin-12 production (GO:0032695)3.06725105
69myeloid cell activation involved in immune response (GO:0002275)3.06571659
70positive regulation of leukocyte degranulation (GO:0043302)3.05690021
71negative regulation of mast cell activation (GO:0033004)3.03719995
72positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.01057999
73positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.00986086
74protein hydroxylation (GO:0018126)3.00262386
75macrophage differentiation (GO:0030225)2.99150516
76positive regulation of gamma-delta T cell activation (GO:0046645)2.96829539
77detection of bacterium (GO:0016045)2.95753120
78skeletal muscle adaptation (GO:0043501)2.95750628
79negative regulation of leukocyte mediated immunity (GO:0002704)2.93398758
80regulation of interferon-alpha production (GO:0032647)2.92075928
81regulation of superoxide anion generation (GO:0032928)2.91404968
82phospholipid efflux (GO:0033700)2.91078942
83negative regulation of erythrocyte differentiation (GO:0045647)2.90880000
84actin nucleation (GO:0045010)2.89707841
85leukocyte cell-cell adhesion (GO:0007159)2.89028286
86negative regulation of myeloid cell apoptotic process (GO:0033033)2.88388712
87leukocyte mediated cytotoxicity (GO:0001909)2.87469357
88histone H3-K36 demethylation (GO:0070544)2.86862903
89positive regulation of Cdc42 GTPase activity (GO:0043089)2.86069860
90regulation of gamma-delta T cell activation (GO:0046643)2.85143762
91granulocyte chemotaxis (GO:0071621)2.85036210
92phagosome maturation (GO:0090382)2.83565803
93oligosaccharide catabolic process (GO:0009313)2.83003471
94response to muramyl dipeptide (GO:0032495)2.81557432
95negative regulation of cytokine production involved in immune response (GO:0002719)2.80616682
96leukotriene biosynthetic process (GO:0019370)2.78481630
97positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.77909184
98sequestering of metal ion (GO:0051238)2.77568278
99response to laminar fluid shear stress (GO:0034616)2.77496231
100cellular response to type I interferon (GO:0071357)2.77487570
101type I interferon signaling pathway (GO:0060337)2.77487570
102negative regulation of fatty acid biosynthetic process (GO:0045717)2.76782542
103histone lysine demethylation (GO:0070076)2.76699219
104macrophage activation (GO:0042116)2.76614057
105granulocyte migration (GO:0097530)2.76461704
106positive regulation of antigen processing and presentation (GO:0002579)2.74956058
107barbed-end actin filament capping (GO:0051016)2.74372848
108regulation of B cell differentiation (GO:0045577)2.74248675
109cholesterol efflux (GO:0033344)2.72137311
110response to type I interferon (GO:0034340)2.71906649
111histone demethylation (GO:0016577)2.69660934
112regulation of T-helper 2 cell differentiation (GO:0045628)2.69313779
113intestinal absorption (GO:0050892)2.67096666
114anatomical structure regression (GO:0060033)2.66934984
115positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.65469978
116T-helper 1 type immune response (GO:0042088)2.65283806
117negative regulation of interleukin-6 production (GO:0032715)2.64941109
118regulation of dendritic cell antigen processing and presentation (GO:0002604)2.64266019
119peptide catabolic process (GO:0043171)2.62918361
120positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.62558854
121diacylglycerol metabolic process (GO:0046339)2.61762915
122alpha-linolenic acid metabolic process (GO:0036109)2.60827623
123positive regulation of p38MAPK cascade (GO:1900745)2.60177323
124germinal center formation (GO:0002467)2.59716431
125positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.58654486
126lipopolysaccharide-mediated signaling pathway (GO:0031663)2.58301667
127lipoprotein transport (GO:0042953)2.56271331
128negative regulation of phagocytosis (GO:0050765)2.55290039
129plasma lipoprotein particle organization (GO:0071827)2.54870818
130regulation of activation of Janus kinase activity (GO:0010533)2.53991314
131adhesion of symbiont to host cell (GO:0044650)2.53574699
132virion attachment to host cell (GO:0019062)2.53574699
133regulation of podosome assembly (GO:0071801)2.52174912
134leukocyte degranulation (GO:0043299)2.50989669
135B cell receptor signaling pathway (GO:0050853)2.49318214
136interferon-gamma-mediated signaling pathway (GO:0060333)2.46946305
137positive regulation of cellular amide metabolic process (GO:0034250)2.46347524
138lipoxygenase pathway (GO:0019372)2.45297294
139positive regulation of regulated secretory pathway (GO:1903307)2.44706667
140positive regulation of toll-like receptor signaling pathway (GO:0034123)2.44125472
141negative regulation of toll-like receptor signaling pathway (GO:0034122)2.43383056
142antigen processing and presentation of endogenous antigen (GO:0019883)2.42563094
143actin filament depolymerization (GO:0030042)2.42516604
144disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.41065373
145killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.41065373
146surfactant homeostasis (GO:0043129)2.40082560
147mannose metabolic process (GO:0006013)2.39525889
148positive regulation of B cell differentiation (GO:0045579)2.38513707
149dendritic cell migration (GO:0036336)2.36912556

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.83990670
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.45182830
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.45407329
4IRF8_27001747_Chip-Seq_BMDM_Mouse3.35318475
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.32308842
6* HIF1A_21447827_ChIP-Seq_MCF-7_Human3.25297912
7MYB_21317192_ChIP-Seq_ERMYB_Mouse3.17058653
8* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.97413530
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.89434177
10* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.85142991
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.64065890
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.62136573
13MYC_22102868_ChIP-Seq_BL_Human2.48546089
14* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.35424584
15SPI1_23127762_ChIP-Seq_K562_Human2.34764634
16BRD4_27068464_Chip-Seq_AML-cells_Mouse2.23653107
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.03681171
18VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.03521769
19PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.01313524
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.00768252
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.00491418
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.00372075
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.00167384
24VDR_21846776_ChIP-Seq_THP-1_Human1.92406745
25VDR_24763502_ChIP-Seq_THP-1_Human1.87383301
26RUNX1_22412390_ChIP-Seq_EML_Mouse1.83837814
27NCOR1_26117541_ChIP-Seq_K562_Human1.83812623
28BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.74654561
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.72358048
30E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.71961786
31ZFP281_18757296_ChIP-ChIP_E14_Mouse1.66508332
32SPI1_23547873_ChIP-Seq_NB4_Human1.65009330
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.63722984
34SCL_19346495_ChIP-Seq_HPC-7_Human1.63440040
35VDR_24787735_ChIP-Seq_THP-1_Human1.61464424
36SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.61407617
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61025563
38NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.60630288
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.60086440
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.59778541
41GATA1_22025678_ChIP-Seq_K562_Human1.57707248
42* MAF_26560356_Chip-Seq_TH1_Human1.56102366
43FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.55618996
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.54835315
45TCF7_22412390_ChIP-Seq_EML_Mouse1.53233596
46MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52987075
47STAT4_19710469_ChIP-ChIP_TH1__Mouse1.52471598
48PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.52063424
49NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.50278012
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.49425351
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.45087233
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.44306132
53RUNX_20019798_ChIP-Seq_JUKART_Human1.42744649
54MYB_26560356_Chip-Seq_TH2_Human1.42418478
55GATA2_21666600_ChIP-Seq_HMVEC_Human1.41970562
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40279330
57SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37692134
58RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37040930
59CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36942619
60RXR_22158963_ChIP-Seq_LIVER_Mouse1.36591474
61FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.35760278
62NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.34447057
63KDM2B_26808549_Chip-Seq_DND41_Human1.33920376
64PU_27001747_Chip-Seq_BMDM_Mouse1.33831382
65* GATA2_19941826_ChIP-Seq_K562_Human1.32362089
66CLOCK_20551151_ChIP-Seq_293T_Human1.32158300
67UTX_26944678_Chip-Seq_JUKART_Human1.32103536
68EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.30726015
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30186722
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29377700
71CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28354368
72* LXR_22292898_ChIP-Seq_THP-1_Human1.26849890
73PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26681050
74EGR1_19374776_ChIP-ChIP_THP-1_Human1.26418526
75SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24974388
76KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24852095
77KDM2B_26808549_Chip-Seq_JURKAT_Human1.24327288
78MYB_26560356_Chip-Seq_TH1_Human1.24079681
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23662781
80SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.23210511
81GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23111678
82PPARA_22158963_ChIP-Seq_LIVER_Mouse1.22453391
83GATA1_19941826_ChIP-Seq_K562_Human1.21902706
84SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.21785277
85GATA1_19941827_ChIP-Seq_MEL_Mouse1.21590376
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20843397
87UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.20741932
88TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20420670
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.19697225
90SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16547850
91GATA3_27048872_Chip-Seq_THYMUS_Human1.14832020
92ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14479755
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14315234
94ELK3_25401928_ChIP-Seq_HUVEC_Human1.14185777
95PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14106509
96SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13556700
97* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.13444335
98GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13435185
99LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12943908
100CDX2_20551321_ChIP-Seq_CACO-2_Human1.11340121
101EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11069559
102DROSHA_22980978_ChIP-Seq_HELA_Human1.10438153
103P68_20966046_ChIP-Seq_HELA_Human1.09687356
104CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09395921
105BCL6_27268052_Chip-Seq_Bcells_Human1.08600133
106EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.06607105
107SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06265571
108SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human1.05486218
109CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05444038
110RBPJ_22232070_ChIP-Seq_NCS_Mouse1.04284189
111ZNF263_19887448_ChIP-Seq_K562_Human1.04245957
112PU.1_20513432_ChIP-Seq_Bcells_Mouse1.04227811
113KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.03642375
114STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03472025
115KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02628558
116ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00423129
117ESR2_21235772_ChIP-Seq_MCF-7_Human0.99993551
118TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99961186
119* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99766607
120DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97157816
121P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97009595
122SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96284280
123RUNX1_27514584_Chip-Seq_MCF-7_Human0.95092728
124KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94018853
125RARG_19884340_ChIP-ChIP_MEFs_Mouse0.93745333
126* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92821708
127JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92105464
128JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91536705
129GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91152575
130SMRT_27268052_Chip-Seq_Bcells_Human0.90315061
131GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89833863
132KDM2B_26808549_Chip-Seq_K562_Human0.88711068
133GATA3_26560356_Chip-Seq_TH2_Human0.88481390
134SPI1_20517297_ChIP-Seq_HL60_Human0.88381026
135* RACK7_27058665_Chip-Seq_MCF-7_Human0.86568855
136BCOR_27268052_Chip-Seq_Bcells_Human0.86206716
137EGR1_19032775_ChIP-ChIP_M12_Human0.85188670
138MAF_26560356_Chip-Seq_TH2_Human0.84033761
139* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.83355347

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology3.84963959
2MP0003183_abnormal_peptide_metabolism3.75980810
3MP0003436_decreased_susceptibility_to3.69408122
4MP0003303_peritoneal_inflammation3.40557455
5MP0005451_abnormal_body_composition2.99608354
6MP0002419_abnormal_innate_immunity2.95947796
7MP0003122_maternal_imprinting2.92442282
8MP0003878_abnormal_ear_physiology2.82031938
9MP0005377_hearing/vestibular/ear_phenot2.82031938
10MP0001835_abnormal_antigen_presentation2.81002200
11MP0002132_abnormal_respiratory_system2.67844987
12MP0009785_altered_susceptibility_to2.61716871
13MP0005360_urolithiasis2.51241923
14MP0009278_abnormal_bone_marrow2.50812858
15MP0000569_abnormal_digit_pigmentation2.27361359
16MP0005000_abnormal_immune_tolerance2.26047787
17MP0003172_abnormal_lysosome_physiology2.25989563
18MP0002148_abnormal_hypersensitivity_rea2.22697697
19MP0005025_abnormal_response_to2.22280845
20MP0003191_abnormal_cellular_cholesterol2.22227752
21MP0004264_abnormal_extraembryonic_tissu2.20085305
22MP0001790_abnormal_immune_system2.18596025
23MP0005387_immune_system_phenotype2.18596025
24MP0003300_gastrointestinal_ulcer2.18499867
25MP0005464_abnormal_platelet_physiology2.16964446
26MP0005408_hypopigmentation2.15978217
27MP0001533_abnormal_skeleton_physiology2.13934511
28MP0002452_abnormal_antigen_presenting2.12655468
29MP0004782_abnormal_surfactant_physiolog2.07869300
30MP0003724_increased_susceptibility_to2.00165983
31MP0009840_abnormal_foam_cell1.97232667
32MP0001819_abnormal_immune_cell1.91498110
33MP0002420_abnormal_adaptive_immunity1.90215956
34MP0000343_altered_response_to1.88467936
35MP0002723_abnormal_immune_serum1.86344794
36MP0002405_respiratory_system_inflammati1.84301647
37MP0001800_abnormal_humoral_immune1.84071143
38MP0000685_abnormal_immune_system1.80712755
39MP0003075_altered_response_to1.79444152
40MP0002877_abnormal_melanocyte_morpholog1.78698486
41MP0003123_paternal_imprinting1.75840173
42MP0004510_myositis1.75663650
43MP0001873_stomach_inflammation1.70163391
44MP0004381_abnormal_hair_follicle1.68313716
45MP0005167_abnormal_blood-brain_barrier1.67326893
46MP0001958_emphysema1.63813061
47MP0006082_CNS_inflammation1.60859525
48MP0001845_abnormal_inflammatory_respons1.58687784
49MP0005410_abnormal_fertilization1.57665155
50MP0005310_abnormal_salivary_gland1.57285805
51MP0002933_joint_inflammation1.56034798
52MP0004947_skin_inflammation1.54871873
53MP0000465_gastrointestinal_hemorrhage1.52865236
54MP0010155_abnormal_intestine_physiology1.51429314
55MP0003221_abnormal_cardiomyocyte_apopto1.51408955
56MP0005166_decreased_susceptibility_to1.48752407
57MP0005248_abnormal_Harderian_gland1.47201405
58MP0005084_abnormal_gallbladder_morpholo1.39971613
59MP0001853_heart_inflammation1.39104862
60MP0004130_abnormal_muscle_cell1.36855959
61MP0009764_decreased_sensitivity_to1.32038312
62MP0000371_diluted_coat_color1.30319652
63MP0001545_abnormal_hematopoietic_system1.29271982
64MP0005397_hematopoietic_system_phenotyp1.29271982
65MP0000604_amyloidosis1.29072260
66MP0001663_abnormal_digestive_system1.28780145
67MP0000716_abnormal_immune_system1.27464888
68MP0005076_abnormal_cell_differentiation1.26917922
69MP0005671_abnormal_response_to1.26560112
70MP0001851_eye_inflammation1.25738809
71MP0005174_abnormal_tail_pigmentation1.25395376
72MP0000015_abnormal_ear_pigmentation1.23626235
73MP0003448_altered_tumor_morphology1.23600641
74MP0003656_abnormal_erythrocyte_physiolo1.23567386
75MP0002396_abnormal_hematopoietic_system1.19811439
76MP0002166_altered_tumor_susceptibility1.18625881
77MP0000858_altered_metastatic_potential1.17831947
78MP0005085_abnormal_gallbladder_physiolo1.15865236
79MP0002928_abnormal_bile_duct1.15061726
80MP0008469_abnormal_protein_level1.13883766
81MP0000749_muscle_degeneration1.13525750
82MP0003121_genomic_imprinting1.12779396
83MP0003866_abnormal_defecation1.10604224
84MP0002998_abnormal_bone_remodeling1.10528226
85MP0000678_abnormal_parathyroid_gland1.09941713
86MP0002398_abnormal_bone_marrow1.08372809
87MP0003690_abnormal_glial_cell1.08144121
88MP0004019_abnormal_vitamin_homeostasis1.04599600
89MP0001849_ear_inflammation1.04239220
90MP0000609_abnormal_liver_physiology1.04032519
91MP0003252_abnormal_bile_duct1.03776624
92MP0010329_abnormal_lipoprotein_level1.03667711
93MP0008260_abnormal_autophagy1.02795816
94MP0003315_abnormal_perineum_morphology1.01535723
95MP0008961_abnormal_basal_metabolism1.01052067
96MP0005075_abnormal_melanosome_morpholog1.00811661
97MP0002429_abnormal_blood_cell0.99189812
98MP0010386_abnormal_urinary_bladder0.97632070
99MP0002837_dystrophic_cardiac_calcinosis0.97067369
100MP0001666_abnormal_nutrient_absorption0.96510349
101MP0003279_aneurysm0.96101653
102MP0005381_digestive/alimentary_phenotyp0.95803261
103MP0008995_early_reproductive_senescence0.93721346
104MP0000689_abnormal_spleen_morphology0.93573575
105MP0001915_intracranial_hemorrhage0.90981557
106MP0003566_abnormal_cell_adhesion0.89758756
107MP0005365_abnormal_bile_salt0.88841634
108MP0009333_abnormal_splenocyte_physiolog0.86307182
109MP0002722_abnormal_immune_system0.85309365
110MP0002971_abnormal_brown_adipose0.85028868
111MP0002653_abnormal_ependyma_morphology0.84345358
112MP0000920_abnormal_myelination0.82998894
113MP0005390_skeleton_phenotype0.82383933
114MP0005164_abnormal_response_to0.80561816
115MP0000747_muscle_weakness0.80137621
116MP0002277_abnormal_respiratory_mucosa0.79974803
117MP0004858_abnormal_nervous_system0.79029695
118MP0003828_pulmonary_edema0.78091222
119MP0010352_gastrointestinal_tract_polyps0.76291976
120MP0004808_abnormal_hematopoietic_stem0.75968816
121MP0005409_darkened_coat_color0.75346788
122MP0004272_abnormal_basement_membrane0.74101028
123MP0005023_abnormal_wound_healing0.73315786
124MP0002075_abnormal_coat/hair_pigmentati0.72471592
125MP0003705_abnormal_hypodermis_morpholog0.72367414
126MP0004883_abnormal_blood_vessel0.72147841
127MP0005388_respiratory_system_phenotype0.71557923
128MP0002133_abnormal_respiratory_system0.71557923
129MP0002139_abnormal_hepatobiliary_system0.71374391
130MP0000538_abnormal_urinary_bladder0.70729331
131MP0003091_abnormal_cell_migration0.70409279
132MP0002006_tumorigenesis0.70311321
133MP0005083_abnormal_biliary_tract0.69360191
134MP0000490_abnormal_crypts_of0.68895893
135MP0003045_fibrosis0.68706449
136MP0003795_abnormal_bone_structure0.68526595
137MP0003329_amyloid_beta_deposits0.67919679
138MP0000249_abnormal_blood_vessel0.67820685
139MP0005257_abnormal_intraocular_pressure0.67492253
140MP0004145_abnormal_muscle_electrophysio0.66525673
141MP0010234_abnormal_vibrissa_follicle0.66191539
142MP0001186_pigmentation_phenotype0.65396886
143MP0005584_abnormal_enzyme/coenzyme_acti0.64197609
144MP0000598_abnormal_liver_morphology0.62087426

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.29360097
2Cholecystitis (HP:0001082)6.25979653
3Abnormal gallbladder physiology (HP:0012438)6.25979653
4Eczematoid dermatitis (HP:0000976)5.68089230
5Recurrent bacterial skin infections (HP:0005406)5.35251592
6Recurrent gram-negative bacterial infections (HP:0005420)4.49811724
7Interstitial pulmonary disease (HP:0006530)4.23220584
8Vacuolated lymphocytes (HP:0001922)4.03000193
9Increased cerebral lipofuscin (HP:0011813)3.98142029
10Abnormality of macrophages (HP:0004311)3.86638396
11Gingivitis (HP:0000230)3.71764529
12Obstructive lung disease (HP:0006536)3.68487141
13Chronic obstructive pulmonary disease (HP:0006510)3.68487141
14Optic neuritis (HP:0100653)3.61710642
15Deep venous thrombosis (HP:0002625)3.58099520
16Gastrointestinal infarctions (HP:0005244)3.56263950
17Increased neuronal autofluorescent lipopigment (HP:0002074)3.45363373
18Systemic lupus erythematosus (HP:0002725)3.24312528
19Recurrent fungal infections (HP:0002841)3.21681634
20Ulnar deviation of the wrist (HP:0003049)3.15487407
21Autoimmune thrombocytopenia (HP:0001973)3.10040741
22Recurrent skin infections (HP:0001581)3.08604967
23Dysostosis multiplex (HP:0000943)3.07427269
24Reticulocytosis (HP:0001923)2.98327306
25Myositis (HP:0100614)2.98088658
26Cellulitis (HP:0100658)2.97867599
27Amyloidosis (HP:0011034)2.92899919
28Myopathic facies (HP:0002058)2.92343593
29Peritonitis (HP:0002586)2.88997936
30Spontaneous hematomas (HP:0007420)2.84608707
31Distal arthrogryposis (HP:0005684)2.83655633
32Hematochezia (HP:0002573)2.81134243
33Muscle fiber inclusion bodies (HP:0100299)2.79842232
34Frequent falls (HP:0002359)2.78332398
35Gingival bleeding (HP:0000225)2.75361472
36Mediastinal lymphadenopathy (HP:0100721)2.74354513
37Periodontitis (HP:0000704)2.73678961
38Segmental peripheral demyelination/remyelination (HP:0003481)2.71138879
39Hypochromic microcytic anemia (HP:0004840)2.67225272
40Colitis (HP:0002583)2.64209088
41Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.64097384
42Inflammation of the large intestine (HP:0002037)2.59752771
43Hyperkalemia (HP:0002153)2.59487790
44Abnormality of liposaccharide metabolism (HP:0010968)2.58552485
45Abnormality of glycosphingolipid metabolism (HP:0004343)2.58552485
46Abnormality of glycolipid metabolism (HP:0010969)2.58552485
47Loss of speech (HP:0002371)2.57259964
48Exercise-induced myalgia (HP:0003738)2.55507376
49Cholelithiasis (HP:0001081)2.53440126
50Keratoconjunctivitis sicca (HP:0001097)2.53228267
51Absent frontal sinuses (HP:0002688)2.53108852
52Abnormality of the nasal mucosa (HP:0000433)2.51341111
53Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.49740929
54Joint hemorrhage (HP:0005261)2.46562244
55Episodic fever (HP:0001954)2.46441593
56Nemaline bodies (HP:0003798)2.45931388
57Malnutrition (HP:0004395)2.45291565
58Abnormality of the common coagulation pathway (HP:0010990)2.43696031
59Orchitis (HP:0100796)2.40401112
60Abnormality of the peritoneum (HP:0002585)2.39151501
61Prolonged bleeding time (HP:0003010)2.37721174
62Hypochromic anemia (HP:0001931)2.37124698
63Gastrointestinal inflammation (HP:0004386)2.36958110
64Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.36031954
65Pulmonary infiltrates (HP:0002113)2.34645615
66Chest pain (HP:0100749)2.34039640
67Exercise-induced muscle cramps (HP:0003710)2.33922482
68Nasal polyposis (HP:0100582)2.33674777
69Metaphyseal cupping (HP:0003021)2.33212103
70Thoracic kyphosis (HP:0002942)2.28973954
71Flat acetabular roof (HP:0003180)2.26814951
72Supranuclear gaze palsy (HP:0000605)2.25897574
73Abnormality of reticulocytes (HP:0004312)2.25621481
74Abnormal gallbladder morphology (HP:0012437)2.23440933
75Short femoral neck (HP:0100864)2.22768617
76Urinary glycosaminoglycan excretion (HP:0003541)2.22572143
77Mucopolysacchariduria (HP:0008155)2.22572143
78Hemorrhage of the eye (HP:0011885)2.21464707
79Round ear (HP:0100830)2.20991309
80Encephalitis (HP:0002383)2.20334829
81Glomerulonephritis (HP:0000099)2.20062573
82Pustule (HP:0200039)2.19789672
83Polycythemia (HP:0001901)2.19679266
84Thickened calvaria (HP:0002684)2.19486078
85Keratoconjunctivitis (HP:0001096)2.18061486
86Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.17090579
87Urticaria (HP:0001025)2.16833906
88Osteomyelitis (HP:0002754)2.15628596
89Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.15283550
90Elevated erythrocyte sedimentation rate (HP:0003565)2.15001013
91Peripheral hypomyelination (HP:0007182)2.14296682
92Acanthocytosis (HP:0001927)2.13199818
93Type 1 muscle fiber predominance (HP:0003803)2.13001703
94Abnormality of polysaccharide metabolism (HP:0011012)2.12694675
95Abnormality of glycosaminoglycan metabolism (HP:0004371)2.12694675
96Abnormality of mucopolysaccharide metabolism (HP:0011020)2.12694675
97Abnormality of glycolysis (HP:0004366)2.12680505
98Alveolar cell carcinoma (HP:0006519)2.12216225
99Spondylolisthesis (HP:0003302)2.12051370
100Asymmetric septal hypertrophy (HP:0001670)2.11301331
101Hyperactive renin-angiotensin system (HP:0000841)2.10061264
102Stomatitis (HP:0010280)2.09816056
103Hepatosplenomegaly (HP:0001433)2.09654724
104Purpura (HP:0000979)2.08459988
105Chronic mucocutaneous candidiasis (HP:0002728)2.07979969
106Recurrent cutaneous fungal infections (HP:0011370)2.07979969
107Xanthomatosis (HP:0000991)2.06933643
108Increased IgE level (HP:0003212)2.06519481
109Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.06384567
110Increased serum ferritin (HP:0003281)2.03992439
111Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.03578815
112Chronic diarrhea (HP:0002028)2.02514224
113Chronic bronchitis (HP:0004469)2.02152441
114Menorrhagia (HP:0000132)2.02075622
115Neurofibrillary tangles (HP:0002185)2.01711741
116Osteolytic defects of the phalanges of the hand (HP:0009771)2.00141242
117Osteolytic defects of the hand bones (HP:0009699)2.00141242
118Hepatoblastoma (HP:0002884)1.99732098
119Abnormality of the lumbar spine (HP:0100712)1.99129991
120Abnormality of the frontal sinuses (HP:0002687)1.97698411
121Epistaxis (HP:0000421)1.95387083
122Axonal loss (HP:0003447)1.95269188
123Anorexia (HP:0002039)1.94130390
124Cheilitis (HP:0100825)1.94065347
125Recurrent pneumonia (HP:0006532)1.93342225
126Neoplasm of the tracheobronchial system (HP:0100552)1.92661468
127Neuronal loss in central nervous system (HP:0002529)1.90396605
128Broad palm (HP:0001169)1.90205604
129Hypercholesterolemia (HP:0003124)1.88122439
130Restrictive lung disease (HP:0002091)1.87461857
131Meningitis (HP:0001287)1.86286807
132Disinhibition (HP:0000734)1.86060445
133Cupped ribs (HP:0000887)1.84920539
134Recurrent viral infections (HP:0004429)1.84710594
135Chronic otitis media (HP:0000389)1.84137983
136Disproportionate tall stature (HP:0001519)1.83814605
137Progressive visual loss (HP:0000529)1.83469399
138Hypobetalipoproteinemia (HP:0003563)1.83297736
139Abnormality of alkaline phosphatase activity (HP:0004379)1.83100715
140Glomerulopathy (HP:0100820)1.80222387
141Osteomalacia (HP:0002749)1.80219277
142Ovoid vertebral bodies (HP:0003300)1.79117491
143Long palpebral fissure (HP:0000637)1.78117069
144Vasculitis (HP:0002633)1.77659028
145Sepsis (HP:0100806)1.77627718
146Stridor (HP:0010307)1.77293344
147Arterial thrombosis (HP:0004420)1.76885386
148Abnormal tarsal ossification (HP:0008369)1.76830604
149Widely patent fontanelles and sutures (HP:0004492)1.76584313
150Peripheral demyelination (HP:0011096)1.75821447
151Epiphyseal dysplasia (HP:0002656)1.74932602
152Abnormality of carpal bone ossification (HP:0006257)1.74423369
153Cerebral aneurysm (HP:0004944)1.74174887
154Abnormality of the gallbladder (HP:0005264)1.74059584
155Abnormal enzyme/coenzyme activity (HP:0012379)1.73936530
156Pathologic fracture (HP:0002756)1.73731644
157Hemoptysis (HP:0002105)1.73079103
158Upper motor neuron abnormality (HP:0002127)1.72340936
159Abnormal delayed hypersensitivity skin test (HP:0002963)1.71397457
160Acute hepatic failure (HP:0006554)1.71209455
161Difficulty running (HP:0009046)1.71193949
162Retrobulbar optic neuritis (HP:0100654)1.70841846
163Premature loss of primary teeth (HP:0006323)1.70234087
164Lymphopenia (HP:0001888)1.69713015
165Abnormal vertebral ossification (HP:0100569)1.68903795
166Small epiphyses (HP:0010585)1.67923300
167Abnormality of T cell physiology (HP:0011840)1.65638484
168Elevated alkaline phosphatase (HP:0003155)1.64704205

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB13.47170976
2PKN23.42023049
3IRAK33.16501758
4IRAK43.03954703
5ERN12.96730508
6MAP2K32.92416703
7BLK2.87954936
8RIPK42.75523104
9FGFR42.60830202
10TTN2.54633604
11MAP4K12.21976323
12CSK2.07778944
13PRPF4B2.02959264
14TESK11.94339697
15TYK21.90132835
16TGFBR21.86551161
17FGR1.85433583
18STK101.82506810
19ZAP701.80835152
20MST41.78512009
21TRIB31.75432066
22CDK191.58366818
23MAP3K141.57881473
24BTK1.57134992
25FRK1.55329103
26GRK61.54172122
27PTK61.53800729
28TBK11.53392378
29YES11.47197923
30HCK1.46920630
31AKT31.45470969
32RIPK11.45302607
33JAK31.42274551
34ERBB31.42092041
35MAP3K31.39557580
36TRPM71.39031705
37CSF1R1.38904302
38FES1.37900875
39RET1.36748560
40PAK41.34850967
41MAP2K61.31114300
42FGFR31.26173138
43TAOK31.24110428
44MAP3K51.24105801
45SIK31.15127235
46SMG11.15118168
47PIK3CG1.14455266
48DYRK1B1.13945320
49JAK11.12123210
50CDK121.05738230
51DMPK1.05682344
52LRRK21.03240093
53MAP3K91.02958251
54KSR11.02586040
55CLK11.02545097
56PHKG21.02405167
57PHKG11.02405167
58PRKG21.01302859
59MARK20.98882053
60TAOK20.97936795
61TEC0.96125070
62NME10.95861379
63MAP3K120.95111132
64FLT30.94924732
65SYK0.93114490
66KSR20.93066244
67MAP2K40.91539715
68MAP3K10.91049899
69FGFR10.90338340
70ITK0.90024217
71TAOK10.89459217
72KIT0.88215512
73PTK2B0.83050022
74MAP3K130.82017480
75RPS6KA20.81812849
76PDK20.79280528
77CAMK1D0.79039174
78MATK0.78910085
79SIK20.77445309
80MARK30.77411387
81TYRO30.75442688
82TNK20.73863043
83EPHA30.73158832
84RAF10.73126984
85MAP3K70.70575226
86SGK30.70211397
87TNIK0.69568828
88BMX0.68133736
89MAP3K80.67816272
90BRD40.67127495
91MOS0.66301069
92JAK20.66204194
93ARAF0.66202531
94PRKD20.66159674
95PTK20.65800180
96PKN10.65631289
97CAMK1G0.65629055
98CAMKK20.65286000
99CAMKK10.65128845
100OBSCN0.64278943
101PDPK10.63405807
102WNK10.62272321
103LCK0.61903884
104MAP3K100.61821673
105MAP3K20.61534005
106ERBB20.61297731
107FYN0.57672591
108MAP3K60.57102880
109CDC42BPA0.56908233
110NEK90.56734555
111IKBKE0.56533701
112TESK20.56055239
113MAPKAPK20.55779918
114PDK30.55035946
115PDK40.55035946
116PDK10.54938399
117PRKCQ0.53954952
118STK240.52654608
119LYN0.51658623
120MAP3K110.51592298
121IKBKB0.50733545
122SIK10.50712606
123NEK20.48782719
124ICK0.48374554
125PRKCD0.46118469
126WNK40.45105209
127PRKCZ0.41527971
128TAF10.40340495
129DDR20.39032616
130CAMK40.38589915
131MAPK40.37974941
132BCKDK0.36589123
133MAPK120.36365603
134MAP2K20.36173794
135PRKAA20.35703734
136RPS6KL10.35577743
137RPS6KC10.35577743
138BRAF0.33794595
139CHUK0.33511275
140EGFR0.33503598
141RPS6KA60.33449501
142PRKCI0.32957776

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.63045812
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.30027072
3Lysosome_Homo sapiens_hsa041422.12887727
4Osteoclast differentiation_Homo sapiens_hsa043802.06413271
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.06302532
6Other glycan degradation_Homo sapiens_hsa005112.02820387
7Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.96669960
8Tuberculosis_Homo sapiens_hsa051521.90104212
9Staphylococcus aureus infection_Homo sapiens_hsa051501.84209573
10B cell receptor signaling pathway_Homo sapiens_hsa046621.83365910
11Pertussis_Homo sapiens_hsa051331.83155835
12HIF-1 signaling pathway_Homo sapiens_hsa040661.82229189
13Mineral absorption_Homo sapiens_hsa049781.73991750
14Central carbon metabolism in cancer_Homo sapiens_hsa052301.73737729
15Leukocyte transendothelial migration_Homo sapiens_hsa046701.71274110
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.64343278
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.63697948
18Phagosome_Homo sapiens_hsa041451.62649894
19Renin-angiotensin system_Homo sapiens_hsa046141.59339942
20Salmonella infection_Homo sapiens_hsa051321.59069730
21Cyanoamino acid metabolism_Homo sapiens_hsa004601.55089608
22Carbohydrate digestion and absorption_Homo sapiens_hsa049731.54880124
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.54794505
24Biosynthesis of amino acids_Homo sapiens_hsa012301.54079380
25Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.49081399
26Shigellosis_Homo sapiens_hsa051311.47291803
27Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.42248563
28Toxoplasmosis_Homo sapiens_hsa051451.41993003
29Vitamin digestion and absorption_Homo sapiens_hsa049771.39593088
30Legionellosis_Homo sapiens_hsa051341.30738600
31Notch signaling pathway_Homo sapiens_hsa043301.25360745
32Chemokine signaling pathway_Homo sapiens_hsa040621.20873895
33Fat digestion and absorption_Homo sapiens_hsa049751.20669906
34VEGF signaling pathway_Homo sapiens_hsa043701.18839754
35Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.18021007
36Steroid biosynthesis_Homo sapiens_hsa001001.17782462
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17260561
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16521542
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.16257649
40Complement and coagulation cascades_Homo sapiens_hsa046101.12235656
41Apoptosis_Homo sapiens_hsa042101.12058982
42Sphingolipid metabolism_Homo sapiens_hsa006001.11846575
43NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07582282
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06750407
45Carbon metabolism_Homo sapiens_hsa012001.06670456
46Platelet activation_Homo sapiens_hsa046111.05686939
47Malaria_Homo sapiens_hsa051441.05168128
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04834802
49Neurotrophin signaling pathway_Homo sapiens_hsa047221.03784088
50Endocytosis_Homo sapiens_hsa041441.03510365
51Caffeine metabolism_Homo sapiens_hsa002321.01878867
52Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98409134
53Hematopoietic cell lineage_Homo sapiens_hsa046400.95451961
54Influenza A_Homo sapiens_hsa051640.95009842
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.94831520
56Dorso-ventral axis formation_Homo sapiens_hsa043200.94649036
57Galactose metabolism_Homo sapiens_hsa000520.94038499
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93639430
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93574553
60Measles_Homo sapiens_hsa051620.93177259
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.92089445
62Rheumatoid arthritis_Homo sapiens_hsa053230.91942833
63Pancreatic cancer_Homo sapiens_hsa052120.91858357
64NF-kappa B signaling pathway_Homo sapiens_hsa040640.91328119
65Type II diabetes mellitus_Homo sapiens_hsa049300.90514243
66Viral myocarditis_Homo sapiens_hsa054160.89949301
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.89117042
68TNF signaling pathway_Homo sapiens_hsa046680.88779005
69Hepatitis C_Homo sapiens_hsa051600.86960291
70Starch and sucrose metabolism_Homo sapiens_hsa005000.85670685
71Pentose phosphate pathway_Homo sapiens_hsa000300.83709278
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81711747
73Acute myeloid leukemia_Homo sapiens_hsa052210.81437276
74Chronic myeloid leukemia_Homo sapiens_hsa052200.81409628
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80576286
76Herpes simplex infection_Homo sapiens_hsa051680.80472777
77T cell receptor signaling pathway_Homo sapiens_hsa046600.79643726
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77000663
79African trypanosomiasis_Homo sapiens_hsa051430.75221144
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74580727
81Insulin resistance_Homo sapiens_hsa049310.74337547
82Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73774759
83Viral carcinogenesis_Homo sapiens_hsa052030.71987317
84Amoebiasis_Homo sapiens_hsa051460.70927623
85RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70146256
86Fatty acid biosynthesis_Homo sapiens_hsa000610.69848394
87Hepatitis B_Homo sapiens_hsa051610.68446673
88mTOR signaling pathway_Homo sapiens_hsa041500.68207696
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.66704690
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66012038
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64443787
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.64009323
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.62788146
94Inositol phosphate metabolism_Homo sapiens_hsa005620.62716408
95Insulin signaling pathway_Homo sapiens_hsa049100.61048771
96GnRH signaling pathway_Homo sapiens_hsa049120.59078683
97Thyroid cancer_Homo sapiens_hsa052160.59012066
98ErbB signaling pathway_Homo sapiens_hsa040120.58658887
99Antigen processing and presentation_Homo sapiens_hsa046120.58631759
100Graft-versus-host disease_Homo sapiens_hsa053320.58382075
101Choline metabolism in cancer_Homo sapiens_hsa052310.57922341
102Bladder cancer_Homo sapiens_hsa052190.57701145
103Collecting duct acid secretion_Homo sapiens_hsa049660.56928638
104Prolactin signaling pathway_Homo sapiens_hsa049170.56173892
105FoxO signaling pathway_Homo sapiens_hsa040680.54583062
106Glycerolipid metabolism_Homo sapiens_hsa005610.54377316
107Allograft rejection_Homo sapiens_hsa053300.54277636
108Non-small cell lung cancer_Homo sapiens_hsa052230.53284578
109Focal adhesion_Homo sapiens_hsa045100.53183883
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50681466
111Gastric acid secretion_Homo sapiens_hsa049710.50680741
112Proteoglycans in cancer_Homo sapiens_hsa052050.50252790
113Renin secretion_Homo sapiens_hsa049240.50188576
114* Fructose and mannose metabolism_Homo sapiens_hsa000510.49420824
115Vibrio cholerae infection_Homo sapiens_hsa051100.49069309
116Adherens junction_Homo sapiens_hsa045200.48658083
117Ether lipid metabolism_Homo sapiens_hsa005650.48648255
118MAPK signaling pathway_Homo sapiens_hsa040100.48555002
119ABC transporters_Homo sapiens_hsa020100.48354522
120Renal cell carcinoma_Homo sapiens_hsa052110.48046909
121Endometrial cancer_Homo sapiens_hsa052130.46590287
122Autoimmune thyroid disease_Homo sapiens_hsa053200.46476521
123Oxytocin signaling pathway_Homo sapiens_hsa049210.46061282
124Estrogen signaling pathway_Homo sapiens_hsa049150.45602840
125Protein digestion and absorption_Homo sapiens_hsa049740.45185856
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.44746641
127Colorectal cancer_Homo sapiens_hsa052100.42359786
128PPAR signaling pathway_Homo sapiens_hsa033200.42303230

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