PFKM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type. This gene encodes the muscle-type isozyme. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.43994111
2negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.34047745
3sarcoplasmic reticulum calcium ion transport (GO:0070296)5.22680994
4muscle filament sliding (GO:0030049)5.20963008
5actin-myosin filament sliding (GO:0033275)5.20963008
6plasma membrane repair (GO:0001778)5.02660524
7regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.02377487
8negative regulation of potassium ion transmembrane transport (GO:1901380)4.96232298
9sarcomere organization (GO:0045214)4.83864730
10regulation of skeletal muscle contraction (GO:0014819)4.80543447
11regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.75262377
12regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.61930388
13membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.55090245
14cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.50316268
15regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.49000635
16synaptic vesicle maturation (GO:0016188)4.41476265
17regulation of cell communication by electrical coupling (GO:0010649)4.40351180
18myofibril assembly (GO:0030239)4.38423672
19cardiac muscle contraction (GO:0060048)4.33601932
20cardiac myofibril assembly (GO:0055003)4.33289654
21regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.27781209
22striated muscle contraction (GO:0006941)4.21225462
23tricarboxylic acid cycle (GO:0006099)4.21135194
24actin-mediated cell contraction (GO:0070252)4.16578591
25cell communication by electrical coupling (GO:0010644)4.11783913
26regulation of membrane repolarization (GO:0060306)4.08077199
27regulation of short-term neuronal synaptic plasticity (GO:0048172)4.03904542
28neuronal action potential propagation (GO:0019227)4.03402260
29response to muscle activity (GO:0014850)4.00586365
30regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.94500873
31skeletal muscle fiber development (GO:0048741)3.85267328
32skeletal muscle contraction (GO:0003009)3.85117922
33regulation of synapse structural plasticity (GO:0051823)3.81936753
34regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.81213708
35locomotory exploration behavior (GO:0035641)3.76367348
36regulation of calcium ion transmembrane transporter activity (GO:1901019)3.71095746
37regulation of calcium ion transmembrane transport (GO:1903169)3.71095746
38cell communication involved in cardiac conduction (GO:0086065)3.68545116
39regulation of relaxation of muscle (GO:1901077)3.66998584
40regulation of actin filament-based movement (GO:1903115)3.66207534
41myotube cell development (GO:0014904)3.64467561
42regulation of acyl-CoA biosynthetic process (GO:0050812)3.64234092
43vocalization behavior (GO:0071625)3.57766711
44muscle fiber development (GO:0048747)3.57196063
45synaptic vesicle docking involved in exocytosis (GO:0016081)3.55136269
46positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.54706191
47positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.53445471
48glutamate secretion (GO:0014047)3.53093936
49sodium ion export (GO:0071436)3.52858237
50synaptic vesicle exocytosis (GO:0016079)3.52492329
51positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.51112645
52potassium ion import (GO:0010107)3.45539352
53regulation of cofactor metabolic process (GO:0051193)3.40531099
54regulation of coenzyme metabolic process (GO:0051196)3.40531099
55membrane depolarization during action potential (GO:0086010)3.38148343
56positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.37173541
57regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.36679168
58muscle hypertrophy (GO:0014896)3.35934351
59cellular potassium ion homeostasis (GO:0030007)3.35505026
60actomyosin structure organization (GO:0031032)3.32217980
61cardiac muscle tissue morphogenesis (GO:0055008)3.31922607
62activation of protein kinase A activity (GO:0034199)3.29763842
63muscle tissue morphogenesis (GO:0060415)3.29073871
64positive regulation of potassium ion transmembrane transport (GO:1901381)3.28974687
65regulation of the force of heart contraction (GO:0002026)3.27115414
66regulation of cardiac muscle cell contraction (GO:0086004)3.26484961
67carnitine shuttle (GO:0006853)3.24886421
68regulation of synaptic vesicle exocytosis (GO:2000300)3.21836766
69striated muscle adaptation (GO:0014888)3.21692666
70regulation of striated muscle contraction (GO:0006942)3.21032103
71detection of calcium ion (GO:0005513)3.19538539
72negative regulation of potassium ion transport (GO:0043267)3.18670670
73gluconeogenesis (GO:0006094)3.18113773
74regulation of glutamate receptor signaling pathway (GO:1900449)3.17230725
75ventricular cardiac muscle cell action potential (GO:0086005)3.16483793
76actin filament-based movement (GO:0030048)3.15314563
77positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.11715143
78cardiac muscle hypertrophy (GO:0003300)3.10814744
79neurotransmitter secretion (GO:0007269)3.09606596
80regulation of synaptic vesicle transport (GO:1902803)3.09328745
81striated muscle hypertrophy (GO:0014897)3.06619000
82postsynaptic membrane organization (GO:0001941)3.06229556
83negative regulation of cytosolic calcium ion concentration (GO:0051481)3.05324803
84neuromuscular synaptic transmission (GO:0007274)3.05313954
85cardiac muscle cell action potential involved in contraction (GO:0086002)3.05172480
86cardiac muscle cell action potential (GO:0086001)3.04205477
87muscle contraction (GO:0006936)3.02974363
88striated muscle cell development (GO:0055002)3.02421745
89regulation of cation channel activity (GO:2001257)3.02405303
90cardiac conduction (GO:0061337)3.02097994
91NADH metabolic process (GO:0006734)3.00231234
92cardiac muscle cell development (GO:0055013)2.99841942
93proline transport (GO:0015824)2.99509926
94regulation of potassium ion transmembrane transport (GO:1901379)2.97259382
95regulation of potassium ion transmembrane transporter activity (GO:1901016)2.97077692
96glycogen catabolic process (GO:0005980)2.96091541
97heart process (GO:0003015)2.95389732
98heart contraction (GO:0060047)2.95389732
99cardiac muscle hypertrophy in response to stress (GO:0014898)2.95043103
100muscle hypertrophy in response to stress (GO:0003299)2.95043103
101cardiac muscle adaptation (GO:0014887)2.95043103
102skeletal muscle adaptation (GO:0043501)2.94836724
103glucan biosynthetic process (GO:0009250)2.93594154
104glycogen biosynthetic process (GO:0005978)2.93594154
1052-oxoglutarate metabolic process (GO:0006103)2.93392265
106response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.92866213
107response to inactivity (GO:0014854)2.91429146
108negative regulation of calcium ion transmembrane transport (GO:1903170)2.91384202
109negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.91384202
110positive regulation of cation channel activity (GO:2001259)2.90721326
111skeletal muscle tissue development (GO:0007519)2.87400340
112regulation of ion transmembrane transporter activity (GO:0032412)2.85715454
113regulation of heart rate by cardiac conduction (GO:0086091)2.82466917
114myotube differentiation (GO:0014902)2.82230811
115positive regulation of potassium ion transport (GO:0043268)2.81271388
116hexose biosynthetic process (GO:0019319)2.80662173
117muscle structure development (GO:0061061)2.79675606
118relaxation of muscle (GO:0090075)2.79639115
119muscle organ development (GO:0007517)2.78317870
120regulation of transmembrane transporter activity (GO:0022898)2.77474500
121cardiac cell development (GO:0055006)2.76556109
122muscle system process (GO:0003012)2.76192920
123aspartate family amino acid catabolic process (GO:0009068)2.75795352
124pyrimidine ribonucleoside catabolic process (GO:0046133)2.75631737
125regulation of sarcomere organization (GO:0060297)2.74990429
126adult heart development (GO:0007512)2.74502836
127layer formation in cerebral cortex (GO:0021819)2.74169277
128creatine metabolic process (GO:0006600)2.73337754
129glucan catabolic process (GO:0009251)2.73188344
130neurotransmitter-gated ion channel clustering (GO:0072578)2.72983703
131muscle cell fate commitment (GO:0042693)2.71647080
132protein localization to synapse (GO:0035418)2.71621895
133regulation of ATP catabolic process (GO:1903289)2.69568476
134regulation of ATPase activity (GO:0043462)2.69568476
135relaxation of cardiac muscle (GO:0055119)2.66778491
136cellular polysaccharide catabolic process (GO:0044247)2.64045000
137regulation of skeletal muscle cell differentiation (GO:2001014)2.62523618
138myoblast fusion (GO:0007520)2.62350655
139muscle cell development (GO:0055001)2.62277892

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.36218473
2ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.95256907
3RARB_27405468_Chip-Seq_BRAIN_Mouse2.70032777
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.66877918
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.62497552
6DROSHA_22980978_ChIP-Seq_HELA_Human2.50371243
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.46304755
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.46116039
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.46116039
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.30063673
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.26578815
12REST_21632747_ChIP-Seq_MESCs_Mouse2.25221028
13MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.21727405
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.19512882
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.17189355
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.16249454
17EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.11595360
18* REST_18959480_ChIP-ChIP_MESCs_Mouse2.11343951
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.08886679
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.08606772
21GBX2_23144817_ChIP-Seq_PC3_Human1.96768686
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.94946151
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93510182
24IGF1R_20145208_ChIP-Seq_DFB_Human1.85187262
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.83468427
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.83177273
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.81234221
28EP300_21415370_ChIP-Seq_HL-1_Mouse1.73174102
29MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.72763852
30* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.70285118
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.69918880
32DNAJC2_21179169_ChIP-ChIP_NT2_Human1.63405797
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.59176763
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.58587612
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.55642756
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54892781
37EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.45580509
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.45022418
39TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43805056
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.42288282
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.41654017
42KDM2B_26808549_Chip-Seq_K562_Human1.41486566
43SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.40894503
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.38704251
45TBX20_22328084_ChIP-Seq_HEART_Mouse1.38542204
46TBX20_22080862_ChIP-Seq_HEART_Mouse1.38542204
47AR_21572438_ChIP-Seq_LNCaP_Human1.37398764
48RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.36387779
49GATA4_21415370_ChIP-Seq_HL-1_Mouse1.34687769
50WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.33740432
51CTCF_27219007_Chip-Seq_Bcells_Human1.30177326
52SOX2_21211035_ChIP-Seq_LN229_Gbm1.29476437
53CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.28262478
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.26536454
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24960365
56RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24313622
57ISL1_27105846_Chip-Seq_CPCs_Mouse1.24300036
58RING1B_27294783_Chip-Seq_ESCs_Mouse1.24269422
59ZNF274_21170338_ChIP-Seq_K562_Hela1.24236449
60SOX9_26525672_Chip-Seq_HEART_Mouse1.22768984
61* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18073239
62KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17552114
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17376707
64* AR_19668381_ChIP-Seq_PC3_Human1.16270315
65ZNF263_19887448_ChIP-Seq_K562_Human1.14751557
66SMAD4_21799915_ChIP-Seq_A2780_Human1.14430410
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13958269
68ZFP57_27257070_Chip-Seq_ESCs_Mouse1.12767842
69OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.12649126
70NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11732806
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09722153
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09679895
73SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09248159
74ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08827271
75RNF2_27304074_Chip-Seq_NSC_Mouse1.08275816
76E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06240913
77EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03911296
78ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03592459
79TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.03245148
80FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02951476
81NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.02940869
82CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02773352
83* SMC4_20622854_ChIP-Seq_HELA_Human1.02312503
84RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02092288
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02010267
86SMAD3_21741376_ChIP-Seq_HESCs_Human1.01220048
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00989770
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00793582
89CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99512180
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99086143
91LXR_22292898_ChIP-Seq_THP-1_Human0.98968675
92ESR2_21235772_ChIP-Seq_MCF-7_Human0.98787458
93SMAD4_21741376_ChIP-Seq_HESCs_Human0.97053478
94WT1_19549856_ChIP-ChIP_CCG9911_Human0.96646845
95BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95734637
96TET1_21490601_ChIP-Seq_MESCs_Mouse0.95389281
97SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95000546
98PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94701570
99TP53_20018659_ChIP-ChIP_R1E_Mouse0.94432588
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93970940
101TAF15_26573619_Chip-Seq_HEK293_Human0.93439143
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93399806
103KLF4_19829295_ChIP-Seq_ESCs_Human0.92292841
104MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91324878
105POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.90793054
106TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90617915
107P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90357770
108NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88033073
109RING1B_27294783_Chip-Seq_NPCs_Mouse0.87858631
110* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.87820218
111DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87022269
112* OCT4_19829295_ChIP-Seq_ESCs_Human0.86336068
113* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85336378
114CTBP2_25329375_ChIP-Seq_LNCAP_Human0.85271963
115PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.85248292
116* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.85007666
117SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84877446
118AHR_22903824_ChIP-Seq_MCF-7_Human0.84816283
119NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.83734392
120ARNT_22903824_ChIP-Seq_MCF-7_Human0.83696791
121KDM2B_26808549_Chip-Seq_DND41_Human0.83376173
122ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83233984
123* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.81494656
124TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.81119738
125PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.80845527
126TP63_22573176_ChIP-Seq_HFKS_Human0.80760088
127HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.80754704
128ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.80669690
129SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80640601
130CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80439559
131STAT3_23295773_ChIP-Seq_U87_Human0.80190068
132NFIB_24661679_ChIP-Seq_LUNG_Mouse0.79535494
133FUS_26573619_Chip-Seq_HEK293_Human0.79299785
134LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79192201

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.72361238
2MP0000751_myopathy4.66072824
3MP0002837_dystrophic_cardiac_calcinosis4.57940889
4MP0004859_abnormal_synaptic_plasticity3.97081837
5MP0004145_abnormal_muscle_electrophysio3.92966253
6* MP0000749_muscle_degeneration3.35772257
7MP0004036_abnormal_muscle_relaxation3.26986950
8MP0004084_abnormal_cardiac_muscle3.22287151
9MP0004215_abnormal_myocardial_fiber3.20459628
10MP0004270_analgesia2.56707623
11MP0003635_abnormal_synaptic_transmissio2.48505615
12MP0000747_muscle_weakness2.43692377
13* MP0004087_abnormal_muscle_fiber2.40159471
14* MP0002106_abnormal_muscle_physiology2.35179570
15MP0005620_abnormal_muscle_contractility2.34015867
16MP0004130_abnormal_muscle_cell2.33533297
17MP0002269_muscular_atrophy2.29689728
18MP0005330_cardiomyopathy2.27833535
19MP0003880_abnormal_central_pattern2.22301909
20MP0009046_muscle_twitch2.15914074
21MP0003137_abnormal_impulse_conducting2.15604339
22* MP0000759_abnormal_skeletal_muscle2.10168608
23* MP0005369_muscle_phenotype1.98012598
24MP0004233_abnormal_muscle_weight1.97589203
25MP0009745_abnormal_behavioral_response1.97366205
26MP0002822_catalepsy1.97074686
27MP0002972_abnormal_cardiac_muscle1.94102230
28MP0002064_seizures1.88311324
29MP0002063_abnormal_learning/memory/cond1.87690090
30MP0004484_altered_response_of1.86431851
31MP0004858_abnormal_nervous_system1.66429768
32MP0004085_abnormal_heartbeat1.66156064
33MP0002909_abnormal_adrenal_gland1.63761259
34MP0002272_abnormal_nervous_system1.60182133
35MP0008775_abnormal_heart_ventricle1.57920487
36* MP0000750_abnormal_muscle_regeneration1.56746035
37MP0002734_abnormal_mechanical_nocicepti1.54632271
38MP0002572_abnormal_emotion/affect_behav1.52948936
39MP0001486_abnormal_startle_reflex1.41386398
40MP0001968_abnormal_touch/_nociception1.40157756
41* MP0008569_lethality_at_weaning1.39657490
42MP0005385_cardiovascular_system_phenoty1.37860332
43MP0001544_abnormal_cardiovascular_syste1.37860332
44MP0009780_abnormal_chondrocyte_physiolo1.37816589
45MP0006036_abnormal_mitochondrial_physio1.37378760
46MP0005451_abnormal_body_composition1.35998666
47MP0010630_abnormal_cardiac_muscle1.35923935
48MP0006138_congestive_heart_failure1.31412285
49MP0005423_abnormal_somatic_nervous1.31034081
50MP0001440_abnormal_grooming_behavior1.30722341
51MP0006035_abnormal_mitochondrial_morpho1.24257175
52MP0008961_abnormal_basal_metabolism1.23340508
53MP0002067_abnormal_sensory_capabilities1.23266478
54* MP0002332_abnormal_exercise_endurance1.20389316
55MP0000013_abnormal_adipose_tissue1.17274734
56MP0005386_behavior/neurological_phenoty1.15252755
57MP0004924_abnormal_behavior1.15252755
58MP0001501_abnormal_sleep_pattern1.14485118
59MP0001299_abnormal_eye_distance/1.14288368
60MP0004043_abnormal_pH_regulation1.13771657
61MP0002638_abnormal_pupillary_reflex1.11910417
62MP0003329_amyloid_beta_deposits1.09452394
63MP0002108_abnormal_muscle_morphology1.07129581
64MP0001970_abnormal_pain_threshold1.05489024
65MP0002127_abnormal_cardiovascular_syste1.05084354
66MP0010030_abnormal_orbit_morphology1.04460506
67MP0002733_abnormal_thermal_nociception1.04439661
68MP0002736_abnormal_nociception_after1.01907233
69MP0004811_abnormal_neuron_physiology0.99384336
70MP0002735_abnormal_chemical_nociception0.98936970
71MP0003136_yellow_coat_color0.97280569
72MP0002184_abnormal_innervation0.96431091
73MP0003221_abnormal_cardiomyocyte_apopto0.95525292
74MP0004510_myositis0.95306545
75MP0002066_abnormal_motor_capabilities/c0.94932018
76MP0005187_abnormal_penis_morphology0.94592623
77MP0004142_abnormal_muscle_tone0.94228539
78MP0002234_abnormal_pharynx_morphology0.92143170
79MP0000955_abnormal_spinal_cord0.90702820
80MP0003633_abnormal_nervous_system0.90368911
81MP0005623_abnormal_meninges_morphology0.90163212
82MP0003122_maternal_imprinting0.87410607
83MP0005171_absent_coat_pigmentation0.86724088
84MP0001661_extended_life_span0.86451284
85MP0002557_abnormal_social/conspecific_i0.82644238
86MP0004147_increased_porphyrin_level0.79910201
87MP0001984_abnormal_olfaction0.79181756
88MP0002882_abnormal_neuron_morphology0.77668387
89MP0005666_abnormal_adipose_tissue0.77071224
90MP0005646_abnormal_pituitary_gland0.76120466
91MP0003879_abnormal_hair_cell0.75586030
92MP0000372_irregular_coat_pigmentation0.75245768
93MP0004885_abnormal_endolymph0.71174355
94MP0005535_abnormal_body_temperature0.69070057
95MP0000579_abnormal_nail_morphology0.68368893
96MP0001502_abnormal_circadian_rhythm0.67972794
97MP0003631_nervous_system_phenotype0.66853172
98MP0008874_decreased_physiological_sensi0.66603262
99MP0000778_abnormal_nervous_system0.63659647
100MP0005375_adipose_tissue_phenotype0.63494513
101MP0003283_abnormal_digestive_organ0.62385895
102MP0003567_abnormal_fetal_cardiomyocyte0.60165447
103MP0005167_abnormal_blood-brain_barrier0.59660345
104MP0000733_abnormal_muscle_development0.59398947
105MP0004185_abnormal_adipocyte_glucose0.59303233
106MP0000762_abnormal_tongue_morphology0.58613433
107MP0002229_neurodegeneration0.58402660
108MP0000003_abnormal_adipose_tissue0.58328226
109MP0001529_abnormal_vocalization0.58257030
110MP0006276_abnormal_autonomic_nervous0.57723109
111* MP0005266_abnormal_metabolism0.57538121
112MP0001346_abnormal_lacrimal_gland0.57343146
113MP0003828_pulmonary_edema0.56964591
114MP0003385_abnormal_body_wall0.55660491
115* MP0000266_abnormal_heart_morphology0.55333282
116MP0002971_abnormal_brown_adipose0.54738123
117MP0003705_abnormal_hypodermis_morpholog0.53971230
118MP0000534_abnormal_ureter_morphology0.53601370
119MP0005670_abnormal_white_adipose0.52603103
120MP0009672_abnormal_birth_weight0.51947015
121MP0002152_abnormal_brain_morphology0.51027075
122MP0002752_abnormal_somatic_nervous0.49497523
123MP0001943_abnormal_respiration0.48984591

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)6.98349217
2Muscle hypertrophy of the lower extremities (HP:0008968)5.52835672
3Calf muscle hypertrophy (HP:0008981)5.45626925
4Sudden death (HP:0001699)5.19377035
5* Exercise-induced muscle cramps (HP:0003710)5.08422419
6Muscle fiber inclusion bodies (HP:0100299)4.83457502
7Difficulty running (HP:0009046)4.66673801
8Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.64348611
9Abnormality of the calf musculature (HP:0001430)4.35835475
10Muscle fiber splitting (HP:0003555)4.33412680
11Hyporeflexia of lower limbs (HP:0002600)4.16126709
12Nemaline bodies (HP:0003798)4.09773276
13EMG: myopathic abnormalities (HP:0003458)4.04004960
14Type 1 muscle fiber predominance (HP:0003803)4.03706639
15Focal motor seizures (HP:0011153)3.89573545
16* Myoglobinuria (HP:0002913)3.81486789
17Increased connective tissue (HP:0009025)3.63298101
18Ventricular tachycardia (HP:0004756)3.62794625
19Bundle branch block (HP:0011710)3.60011605
20Atrial fibrillation (HP:0005110)3.56090070
21Subaortic stenosis (HP:0001682)3.49861154
22Abnormality of the left ventricular outflow tract (HP:0011103)3.49861154
23Distal arthrogryposis (HP:0005684)3.48677875
24Muscle stiffness (HP:0003552)3.42429336
25Primary atrial arrhythmia (HP:0001692)3.40531558
26Deformed tarsal bones (HP:0008119)3.37680346
27Increased variability in muscle fiber diameter (HP:0003557)3.32625860
28Supraventricular tachycardia (HP:0004755)3.25891974
29Myopathic facies (HP:0002058)3.24943587
30Abnormality of skeletal muscle fiber size (HP:0012084)3.20634472
31Ventricular fibrillation (HP:0001663)3.18140552
32Supraventricular arrhythmia (HP:0005115)3.17274344
33Myokymia (HP:0002411)3.16994184
34* Myotonia (HP:0002486)3.11693456
35Round ear (HP:0100830)3.06743102
36Visual hallucinations (HP:0002367)3.06232680
37Prolonged QT interval (HP:0001657)2.99400654
38Difficulty climbing stairs (HP:0003551)2.98082446
39Rhabdomyolysis (HP:0003201)2.97649994
40Syncope (HP:0001279)2.90356611
41Asymmetric septal hypertrophy (HP:0001670)2.85766089
42Focal seizures (HP:0007359)2.84612873
43Ventricular arrhythmia (HP:0004308)2.82929880
44Heart block (HP:0012722)2.73021794
45Dysmetric saccades (HP:0000641)2.66400291
46Abnormal EKG (HP:0003115)2.64844962
47Generalized muscle weakness (HP:0003324)2.57384374
48EMG: neuropathic changes (HP:0003445)2.57311993
49Abnormal atrioventricular conduction (HP:0005150)2.57005931
50Lipoatrophy (HP:0100578)2.56650235
51Atonic seizures (HP:0010819)2.51202428
52Ulnar deviation of the wrist (HP:0003049)2.47588499
53Neck muscle weakness (HP:0000467)2.46722509
54Abnormal finger flexion creases (HP:0006143)2.45639586
55Abnormality of the lower motor neuron (HP:0002366)2.43724749
56Pheochromocytoma (HP:0002666)2.42643019
57Scapular winging (HP:0003691)2.41674234
58Febrile seizures (HP:0002373)2.40262399
59Palpitations (HP:0001962)2.39098380
60Epileptic encephalopathy (HP:0200134)2.37469511
61Atrioventricular block (HP:0001678)2.35656412
62Malignant hyperthermia (HP:0002047)2.33925733
63Abnormality of the foot musculature (HP:0001436)2.32859484
64Generalized tonic-clonic seizures (HP:0002069)2.30139970
65Right ventricular cardiomyopathy (HP:0011663)2.29676159
66Dilated cardiomyopathy (HP:0001644)2.28625949
67Mildly elevated creatine phosphokinase (HP:0008180)2.27321621
68Rimmed vacuoles (HP:0003805)2.26508070
69Abnormality of the calcaneus (HP:0008364)2.23956988
70Absence seizures (HP:0002121)2.22248174
71Lower limb amyotrophy (HP:0007210)2.18578404
72Limb-girdle muscle atrophy (HP:0003797)2.18168628
73Areflexia of lower limbs (HP:0002522)2.17425143
74Left ventricular hypertrophy (HP:0001712)2.14766879
75Frequent falls (HP:0002359)2.12261737
76Neuroendocrine neoplasm (HP:0100634)2.11821242
77Poor eye contact (HP:0000817)2.11432420
78Depression (HP:0000716)2.11137427
79Spinal rigidity (HP:0003306)2.11028530
80Foot dorsiflexor weakness (HP:0009027)2.10753619
81Distal lower limb amyotrophy (HP:0008944)2.10199920
82Shoulder girdle muscle weakness (HP:0003547)2.08449359
83Dysdiadochokinesis (HP:0002075)2.07707748
84Dialeptic seizures (HP:0011146)2.06481100
85Resting tremor (HP:0002322)2.06407132
86Abnormality of the shoulder girdle musculature (HP:0001435)2.05592084
87Action tremor (HP:0002345)2.05383638
88Ankle clonus (HP:0011448)2.03070359
89Broad-based gait (HP:0002136)2.03027384
90Fetal akinesia sequence (HP:0001989)2.02508858
91Progressive muscle weakness (HP:0003323)2.02427780
92Abnormal social behavior (HP:0012433)2.01919520
93Impaired social interactions (HP:0000735)2.01919520
94Testicular atrophy (HP:0000029)2.01394674
95Limb-girdle muscle weakness (HP:0003325)1.99485662
96Bulbar palsy (HP:0001283)1.99145463
97Impaired vibration sensation in the lower limbs (HP:0002166)1.97829919
98Calcaneovalgus deformity (HP:0001848)1.95783804
99Weak cry (HP:0001612)1.94901166
100Proximal amyotrophy (HP:0007126)1.94439702
101Rapidly progressive (HP:0003678)1.94272753
102Slender build (HP:0001533)1.93010887
103Muscular dystrophy (HP:0003560)1.92215873
104Ragged-red muscle fibers (HP:0003200)1.92109076
105Achilles tendon contracture (HP:0001771)1.89987099
106Distal lower limb muscle weakness (HP:0009053)1.88925778
107Respiratory insufficiency due to muscle weakness (HP:0002747)1.87572024
108Abnormality of the hip-girdle musculature (HP:0001445)1.86674473
109Abnormality of the musculature of the pelvis (HP:0001469)1.86674473
110Urinary urgency (HP:0000012)1.85818378
111Anxiety (HP:0000739)1.83915659
112Gowers sign (HP:0003391)1.83722973
113Hamartoma of the eye (HP:0010568)1.83010475
114Absent phalangeal crease (HP:0006109)1.82854815
115Progressive cerebellar ataxia (HP:0002073)1.82631590
116Centrally nucleated skeletal muscle fibers (HP:0003687)1.82622690
117Hyperkalemia (HP:0002153)1.81471478
118Hip contracture (HP:0003273)1.77701889
119Steppage gait (HP:0003376)1.75741736
120Abnormality of the neuromuscular junction (HP:0003398)1.75410693
121Fatigable weakness (HP:0003473)1.75410693
122Abnormality of glycolysis (HP:0004366)1.73760327
123Pelvic girdle muscle weakness (HP:0003749)1.72566305
124Waddling gait (HP:0002515)1.70526601
125Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.62768710
126* Exercise intolerance (HP:0003546)1.60522886
127Adducted thumb (HP:0001181)1.56727737
128Metatarsus adductus (HP:0001840)1.55197159
129Increased serum pyruvate (HP:0003542)1.54653286
130Long clavicles (HP:0000890)1.47569329

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PHKG14.14786654
2PHKG24.14786654
3OBSCN3.73602689
4TTN3.71188957
5PDK32.63436219
6PDK42.63436219
7NTRK32.51365547
8NEK12.49699813
9LMTK22.35439235
10EPHA42.33201141
11MAP3K92.22490513
12PINK12.15978825
13MAP3K42.11197773
14MAP2K42.10397664
15PRKD31.96921111
16TRIB31.81160473
17GRK51.75035311
18PAK61.73369717
19DMPK1.62440581
20DAPK21.53768745
21EEF2K1.51083375
22STK381.49591209
23LIMK11.47798831
24PDK21.46783694
25MINK11.46199888
26NME11.45350268
27KSR21.44795196
28MAP3K71.44220265
29MARK11.41595315
30MUSK1.41520947
31MAP2K71.29441895
32CAMKK11.24403189
33NTRK21.19181718
34MAPK121.17634470
35NTRK11.17064758
36RIPK11.12053451
37PKN21.09857288
38TYRO31.08764736
39CCNB11.08656599
40WNK11.07883557
41PAK30.93074100
42GRK70.92598900
43CAMK40.91872090
44TAOK10.90647866
45CAMK2B0.89416734
46CDK50.89081075
47ERBB30.88116521
48MYLK0.88031981
49PIK3CA0.84268537
50CAMK10.83151953
51LATS20.80329286
52CDK190.79689342
53PRKCH0.77475591
54KSR10.76288721
55MAP3K120.75825906
56CAMK2A0.74925563
57CAMKK20.73570787
58CAMK2D0.72736970
59PRKCG0.72644543
60PRPF4B0.71813377
61BCKDK0.71497238
62PRKAA10.70027060
63DAPK10.69695562
64MAP2K60.67040724
65PKN10.66392546
66SGK30.65741912
67EPHA30.64438849
68CDC42BPA0.64209849
69RET0.63150376
70PDK10.63075740
71PTK2B0.62794196
72TIE10.59726009
73MAPK70.58776318
74DYRK1B0.58406655
75PRKD10.58181658
76UHMK10.57518284
77NEK90.57383047
78CAMK2G0.57223881
79MARK20.56877382
80STK110.56570300
81PDPK10.55816359
82PRKAA20.54929218
83MOS0.54851763
84PIK3CG0.54800234
85PLK20.53993005
86SGK10.53590011
87SGK2230.53429226
88SGK4940.53429226
89ROCK10.53393929
90SGK20.52603966
91ALK0.51020468
92PDGFRA0.47356941
93* RPS6KA30.47345310
94CSNK1G20.46945746
95MAPK130.46652256
96MAP3K10.45834119
97CDK150.45768741
98MAPKAPK30.44925276
99CDK180.44597224
100MET0.44355756
101PRKACB0.43895524
102ROCK20.43729339
103CASK0.43694194
104DAPK30.43576526
105MAP2K30.43221521
106STK38L0.42764148
107TRPM70.42054903
108STK240.41453213
109PRKG10.40978612
110ARAF0.40726802
111PRKACA0.40697821
112TSSK60.40427449
113MAPK100.40081370
114CDK140.39328989
115DYRK1A0.38258448
116AKT20.38219783
117CSNK1G30.37606812
118EPHB20.36890982
119CDK11A0.36649975
120MAP2K10.35921460
121CSNK1A1L0.35624805
122PRKACG0.35361147
123FER0.34889445
124ICK0.34551742
125PNCK0.34522710
126MAPK40.34310698
127CSNK1G10.33710476
128PRKCE0.31151939
129DYRK20.30052051
130RPS6KB10.26659269
131PRKDC0.26174472

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.59400352
2Cardiac muscle contraction_Homo sapiens_hsa042602.90266793
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.53272446
4Dilated cardiomyopathy_Homo sapiens_hsa054142.50785578
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.28621454
6Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.22477212
7Synaptic vesicle cycle_Homo sapiens_hsa047212.20544098
8Nicotine addiction_Homo sapiens_hsa050332.19089201
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.11969892
10Circadian entrainment_Homo sapiens_hsa047132.02350680
11Olfactory transduction_Homo sapiens_hsa047401.99890842
12GABAergic synapse_Homo sapiens_hsa047271.97147683
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.90495160
14Long-term potentiation_Homo sapiens_hsa047201.89131938
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.87827895
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.80030769
17Oxytocin signaling pathway_Homo sapiens_hsa049211.77873734
18Arginine and proline metabolism_Homo sapiens_hsa003301.75140988
19Calcium signaling pathway_Homo sapiens_hsa040201.72238697
20Glutamatergic synapse_Homo sapiens_hsa047241.69595621
21Gastric acid secretion_Homo sapiens_hsa049711.67674970
22Insulin secretion_Homo sapiens_hsa049111.67168906
23Morphine addiction_Homo sapiens_hsa050321.63024589
24Salivary secretion_Homo sapiens_hsa049701.59141327
25Amphetamine addiction_Homo sapiens_hsa050311.53326265
26Renin secretion_Homo sapiens_hsa049241.44696987
27Dopaminergic synapse_Homo sapiens_hsa047281.42503619
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.40361010
29Parkinsons disease_Homo sapiens_hsa050121.36136340
30Cholinergic synapse_Homo sapiens_hsa047251.33522141
31cGMP-PKG signaling pathway_Homo sapiens_hsa040221.29743066
32Glucagon signaling pathway_Homo sapiens_hsa049221.27436467
33Propanoate metabolism_Homo sapiens_hsa006401.26836122
34Oxidative phosphorylation_Homo sapiens_hsa001901.25660026
35GnRH signaling pathway_Homo sapiens_hsa049121.24729112
36Taste transduction_Homo sapiens_hsa047421.24484491
37Alzheimers disease_Homo sapiens_hsa050101.23241023
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.19821506
39* Carbon metabolism_Homo sapiens_hsa012001.18492237
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14897982
41Long-term depression_Homo sapiens_hsa047301.13185187
42Type II diabetes mellitus_Homo sapiens_hsa049301.12578071
43cAMP signaling pathway_Homo sapiens_hsa040241.08653783
44Insulin signaling pathway_Homo sapiens_hsa049101.05391892
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.04070046
46Gap junction_Homo sapiens_hsa045401.00774980
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95378229
48Serotonergic synapse_Homo sapiens_hsa047260.94069848
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92931994
50Pyruvate metabolism_Homo sapiens_hsa006200.90890894
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.87450209
52Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85801137
53Nitrogen metabolism_Homo sapiens_hsa009100.85244730
54* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.84391880
55Circadian rhythm_Homo sapiens_hsa047100.83721949
56Cocaine addiction_Homo sapiens_hsa050300.83392139
57Collecting duct acid secretion_Homo sapiens_hsa049660.82940219
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80477810
59Fatty acid degradation_Homo sapiens_hsa000710.78202951
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77195259
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76979048
62Estrogen signaling pathway_Homo sapiens_hsa049150.76938623
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.76733155
64Insulin resistance_Homo sapiens_hsa049310.76078972
65Fatty acid metabolism_Homo sapiens_hsa012120.74759991
66mTOR signaling pathway_Homo sapiens_hsa041500.74508505
67Huntingtons disease_Homo sapiens_hsa050160.73693747
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73251823
69Fatty acid elongation_Homo sapiens_hsa000620.72206788
70Butanoate metabolism_Homo sapiens_hsa006500.68365863
71* Pentose phosphate pathway_Homo sapiens_hsa000300.68054672
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.67966927
73Melanogenesis_Homo sapiens_hsa049160.67633288
74Glioma_Homo sapiens_hsa052140.67600138
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66118776
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65258343
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.64920155
78Dorso-ventral axis formation_Homo sapiens_hsa043200.64751195
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63511053
80Fatty acid biosynthesis_Homo sapiens_hsa000610.63305314
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63018354
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.62104595
83Pancreatic secretion_Homo sapiens_hsa049720.62009733
84Phenylalanine metabolism_Homo sapiens_hsa003600.61375546
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59425751
86Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57942715
87VEGF signaling pathway_Homo sapiens_hsa043700.57740065
88* AMPK signaling pathway_Homo sapiens_hsa041520.57687729
89MAPK signaling pathway_Homo sapiens_hsa040100.57633238
90Starch and sucrose metabolism_Homo sapiens_hsa005000.56377829
91ErbB signaling pathway_Homo sapiens_hsa040120.53457108
92* Biosynthesis of amino acids_Homo sapiens_hsa012300.52902458
93Lysine degradation_Homo sapiens_hsa003100.52882824
94beta-Alanine metabolism_Homo sapiens_hsa004100.52736493
95Tight junction_Homo sapiens_hsa045300.52275014
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51171390
97Arginine biosynthesis_Homo sapiens_hsa002200.51018497
98Oocyte meiosis_Homo sapiens_hsa041140.50960343
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50033560
100Hedgehog signaling pathway_Homo sapiens_hsa043400.48067526
101Hippo signaling pathway_Homo sapiens_hsa043900.47083767
102Bile secretion_Homo sapiens_hsa049760.46047536
103Inositol phosphate metabolism_Homo sapiens_hsa005620.45740796
104HIF-1 signaling pathway_Homo sapiens_hsa040660.45488281
105Adherens junction_Homo sapiens_hsa045200.44987679
106* Central carbon metabolism in cancer_Homo sapiens_hsa052300.44762704
107Sulfur relay system_Homo sapiens_hsa041220.44278681
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43495283
109* Fructose and mannose metabolism_Homo sapiens_hsa000510.43236466
110Cysteine and methionine metabolism_Homo sapiens_hsa002700.43133901
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42965489
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.42900285
113Axon guidance_Homo sapiens_hsa043600.42662507
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.41343751
115Alcoholism_Homo sapiens_hsa050340.41019306
116Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38014793
117Choline metabolism in cancer_Homo sapiens_hsa052310.37507709
118Focal adhesion_Homo sapiens_hsa045100.37126712
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37001174
120Basal cell carcinoma_Homo sapiens_hsa052170.36816581
121Thyroid hormone synthesis_Homo sapiens_hsa049180.36429277
122Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.32154413

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