PFN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.17668810
2ribosomal small subunit assembly (GO:0000028)4.51798064
3Arp2/3 complex-mediated actin nucleation (GO:0034314)4.11678032
4viral transcription (GO:0019083)4.05185407
5translational termination (GO:0006415)3.92474964
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.90468679
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.90468679
8positive regulation of gamma-delta T cell activation (GO:0046645)3.79396276
9cytidine deamination (GO:0009972)3.72905338
10cytidine metabolic process (GO:0046087)3.72905338
11cytidine catabolic process (GO:0006216)3.72905338
12maturation of SSU-rRNA (GO:0030490)3.69964379
13leukocyte aggregation (GO:0070486)3.69680305
14negative regulation of cell killing (GO:0031342)3.61156676
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.61156676
16sequestering of actin monomers (GO:0042989)3.59893524
17DNA strand elongation involved in DNA replication (GO:0006271)3.58864063
18translational elongation (GO:0006414)3.58314523
19ribosomal small subunit biogenesis (GO:0042274)3.54513914
20telomere maintenance via semi-conservative replication (GO:0032201)3.49503417
21antigen processing and presentation of endogenous antigen (GO:0019883)3.49313084
22positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.49123668
23formation of translation preinitiation complex (GO:0001731)3.42521825
24SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.41139288
25DNA strand elongation (GO:0022616)3.40833456
26positive regulation of B cell differentiation (GO:0045579)3.35969318
27translational initiation (GO:0006413)3.31126070
28protein targeting to ER (GO:0045047)3.30395707
29cotranslational protein targeting to membrane (GO:0006613)3.29754290
30protein maturation by protein folding (GO:0022417)3.29449863
31pyrimidine ribonucleoside catabolic process (GO:0046133)3.26724263
32regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.26288245
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.22472730
34nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.20724284
35DNA unwinding involved in DNA replication (GO:0006268)3.18637961
36viral life cycle (GO:0019058)3.18485197
37regulation of protein heterodimerization activity (GO:0043497)3.15295288
38positive T cell selection (GO:0043368)3.14619988
39protein localization to endoplasmic reticulum (GO:0070972)3.13139168
40establishment of protein localization to endoplasmic reticulum (GO:0072599)3.11458907
41negative thymic T cell selection (GO:0045060)3.11006892
42cellular protein complex disassembly (GO:0043624)3.06187279
43regulation of gamma-delta T cell differentiation (GO:0045586)3.05616231
44telomere maintenance via recombination (GO:0000722)3.05463548
45negative T cell selection (GO:0043383)3.02037764
46positive regulation of lamellipodium assembly (GO:0010592)3.01761150
47DNA replication initiation (GO:0006270)3.00245872
48positive thymic T cell selection (GO:0045059)3.00062127
49positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.98916480
50purine deoxyribonucleotide catabolic process (GO:0009155)2.98359753
51proteasome assembly (GO:0043248)2.98234554
52negative regulation of B cell apoptotic process (GO:0002903)2.96963587
53regulation of defense response to virus by virus (GO:0050690)2.93076821
54T cell selection (GO:0045058)2.90600591
55actin nucleation (GO:0045010)2.90595662
56pinocytosis (GO:0006907)2.90236000
57antigen processing and presentation via MHC class Ib (GO:0002475)2.89443385
58negative regulation of phagocytosis (GO:0050765)2.89331779
59antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.88734147
60regulation of natural killer cell mediated immunity (GO:0002715)2.86149209
61regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.86149209
62ribosomal large subunit biogenesis (GO:0042273)2.85701018
63antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.84298379
64respiratory burst (GO:0045730)2.80015252
65regulation of gamma-delta T cell activation (GO:0046643)2.78699851
66ribonucleoprotein complex biogenesis (GO:0022613)2.77609971
67regulation of T cell tolerance induction (GO:0002664)2.77389718
68negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.77201359
69type I interferon signaling pathway (GO:0060337)2.77126959
70cellular response to type I interferon (GO:0071357)2.77126959
71mature B cell differentiation involved in immune response (GO:0002313)2.76290205
72mitotic recombination (GO:0006312)2.75809191
73protein complex disassembly (GO:0043241)2.75445932
74T cell costimulation (GO:0031295)2.74879056
75positive regulation of T cell mediated cytotoxicity (GO:0001916)2.73932648
76neutrophil activation involved in immune response (GO:0002283)2.71938314
77response to type I interferon (GO:0034340)2.71790676
78lymphocyte costimulation (GO:0031294)2.70600177
79negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.69544692
80immunoglobulin mediated immune response (GO:0016064)2.66480315
81B cell mediated immunity (GO:0019724)2.66069785
82telomere maintenance via telomere lengthening (GO:0010833)2.65935356
83negative regulation of T cell apoptotic process (GO:0070233)2.65852778
84regulation of B cell receptor signaling pathway (GO:0050855)2.65355218
85thymic T cell selection (GO:0045061)2.64740555
86positive regulation of interleukin-8 secretion (GO:2000484)2.64704548
87detection of bacterium (GO:0016045)2.64160000
88NIK/NF-kappaB signaling (GO:0038061)2.63743153
89GDP-mannose metabolic process (GO:0019673)2.63409162
90negative regulation of lymphocyte apoptotic process (GO:0070229)2.62322579
91deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.61897991
92modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.61694854
93positive regulation by organism of defense response of other organism involved in symbiotic interact2.61694854
94modulation by symbiont of host immune response (GO:0052553)2.61694854
95positive regulation by symbiont of host defense response (GO:0052509)2.61694854
96modulation by symbiont of host defense response (GO:0052031)2.61694854
97modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.61694854
98B cell receptor signaling pathway (GO:0050853)2.60684023
99T cell apoptotic process (GO:0070231)2.60281665
100regulation of interleukin-2 biosynthetic process (GO:0045076)2.59949758
101response to peptidoglycan (GO:0032494)2.59453509
102regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.58238536
103negative regulation of interleukin-12 production (GO:0032695)2.58158814
104positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.57214535
105macromolecular complex disassembly (GO:0032984)2.56956768
106negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.56660677
107negative regulation of ligase activity (GO:0051352)2.56660677
108nuclear-transcribed mRNA catabolic process (GO:0000956)2.56242966
109negative regulation of viral genome replication (GO:0045071)2.56007894
110regulation of T cell mediated cytotoxicity (GO:0001914)2.55816094
111establishment of viral latency (GO:0019043)2.54893076
112translation (GO:0006412)2.54834461
113response to interleukin-15 (GO:0070672)2.54354889
114positive regulation of natural killer cell mediated immunity (GO:0002717)2.53814700
115regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.53177349
116positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.52191138
117mitotic nuclear envelope disassembly (GO:0007077)2.52030050
118positive regulation of lamellipodium organization (GO:1902745)2.52005809
119ribosome biogenesis (GO:0042254)2.51905607
120anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.51882409
121cellular response to interleukin-15 (GO:0071350)2.51242361
122T cell receptor signaling pathway (GO:0050852)2.51165361
123DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.50771481
124folic acid-containing compound biosynthetic process (GO:0009396)2.50178133
125rRNA processing (GO:0006364)2.49992253
126negative regulation of leukocyte apoptotic process (GO:2000107)2.49553934
127protein localization to kinetochore (GO:0034501)2.49408625
128intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.48039563
129signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.48039563
130establishment of integrated proviral latency (GO:0075713)2.47779522
131mucosal-associated lymphoid tissue development (GO:0048537)2.47073356
132Peyers patch development (GO:0048541)2.47073356
133antigen receptor-mediated signaling pathway (GO:0050851)2.46810406
134chaperone mediated protein folding requiring cofactor (GO:0051085)2.46487645
135regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.46425134
136detection of other organism (GO:0098543)2.46310136
137antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.46157761
138regulation of leukocyte mediated cytotoxicity (GO:0001910)2.46071178
139signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.45789102
140signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.45789102
141signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.45789102
142regulation of alpha-beta T cell proliferation (GO:0046640)2.45319275
143T cell migration (GO:0072678)2.43708107
144mRNA catabolic process (GO:0006402)2.43540323
145regulation of type I interferon-mediated signaling pathway (GO:0060338)2.43516450
146Golgi transport vesicle coating (GO:0048200)2.42999356
147COPI coating of Golgi vesicle (GO:0048205)2.42999356
148negative regulation of myeloid cell apoptotic process (GO:0033033)2.42897391
149nucleotide-excision repair, DNA gap filling (GO:0006297)2.42378181
150signal transduction involved in DNA damage checkpoint (GO:0072422)2.41058196
151signal transduction involved in DNA integrity checkpoint (GO:0072401)2.41058196
152rRNA metabolic process (GO:0016072)2.40903398
153RNA catabolic process (GO:0006401)2.39724387
154ribosome assembly (GO:0042255)2.39421100
155response to interferon-beta (GO:0035456)2.39377070
156positive regulation of macrophage differentiation (GO:0045651)2.39220040
157positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.39106570
158negative regulation of RNA splicing (GO:0033119)2.39074556
159interferon-gamma production (GO:0032609)2.37674533
160regulation of B cell differentiation (GO:0045577)2.36975268
161nucleobase biosynthetic process (GO:0046112)2.36632138
162positive regulation of isotype switching (GO:0045830)2.36574077
163regulation of translational termination (GO:0006449)2.36403223
164pseudouridine synthesis (GO:0001522)2.36383912
165signal transduction involved in cell cycle checkpoint (GO:0072395)2.35580135
166DNA replication checkpoint (GO:0000076)2.35196309

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.57198757
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.86605149
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.18049775
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.60268775
5* MYC_22102868_ChIP-Seq_BL_Human2.54429701
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.36094988
7* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.35216438
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.34465326
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.24454457
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.22051247
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.20339336
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.17807787
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.17217190
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.17018440
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.15049859
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.12645109
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.12599616
18VDR_21846776_ChIP-Seq_THP-1_Human2.09672042
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.08579803
20* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.05256031
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.05093801
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.04501737
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.95976973
24* XRN2_22483619_ChIP-Seq_HELA_Human1.93846555
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.90379966
26* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.90329086
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.88187251
28* VDR_23849224_ChIP-Seq_CD4+_Human1.86393094
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.80931538
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.78684009
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.74550750
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.74295262
33LXR_22292898_ChIP-Seq_THP-1_Human1.72727439
34SPI1_23547873_ChIP-Seq_NB4_Human1.71784633
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.70841036
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.68151417
37* MAF_26560356_Chip-Seq_TH1_Human1.67346536
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.66998622
39SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.65218951
40* FOXP3_21729870_ChIP-Seq_TREG_Human1.62937512
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.62616053
42STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.62124353
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.61971181
44FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.61220544
45MYB_21317192_ChIP-Seq_ERMYB_Mouse1.60799869
46CIITA_25753668_ChIP-Seq_RAJI_Human1.60646644
47MYB_26560356_Chip-Seq_TH2_Human1.57823361
48* UTX_26944678_Chip-Seq_JUKART_Human1.56841416
49DCP1A_22483619_ChIP-Seq_HELA_Human1.55188971
50* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54389670
51GABP_19822575_ChIP-Seq_HepG2_Human1.53554599
52PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.52358219
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.47120567
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.45033310
55* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42403057
56* MYB_26560356_Chip-Seq_TH1_Human1.41852795
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.40757746
58CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39872928
59RUNX1_22412390_ChIP-Seq_EML_Mouse1.39682561
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38736208
61* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.38478909
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36389043
63SRY_22984422_ChIP-ChIP_TESTIS_Rat1.34026270
64VDR_24763502_ChIP-Seq_THP-1_Human1.32166781
65RARG_19884340_ChIP-ChIP_MEFs_Mouse1.32011747
66TTF2_22483619_ChIP-Seq_HELA_Human1.31924560
67MAF_26560356_Chip-Seq_TH2_Human1.31055542
68ELF1_20517297_ChIP-Seq_JURKAT_Human1.29539059
69BCL6_27268052_Chip-Seq_Bcells_Human1.28992303
70* E2F1_21310950_ChIP-Seq_MCF-7_Human1.28203521
71SCL_19346495_ChIP-Seq_HPC-7_Human1.27230727
72* ELK3_25401928_ChIP-Seq_HUVEC_Human1.27131878
73ZNF263_19887448_ChIP-Seq_K562_Human1.26592032
74NANOG_18555785_ChIP-Seq_MESCs_Mouse1.26277283
75TET1_21451524_ChIP-Seq_MESCs_Mouse1.26244172
76MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.26189336
77FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25466730
78BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24649954
79AR_21909140_ChIP-Seq_LNCAP_Human1.24529459
80ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24119850
81* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23412940
82ELK1_19687146_ChIP-ChIP_HELA_Human1.23288215
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.23156514
84CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18926268
85P68_20966046_ChIP-Seq_HELA_Human1.17355313
86KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17210755
87NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17074594
88TFEB_21752829_ChIP-Seq_HELA_Human1.16665794
89THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16467485
90BCOR_27268052_Chip-Seq_Bcells_Human1.16079198
91MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.15230079
92RACK7_27058665_Chip-Seq_MCF-7_Human1.15182880
93* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15064199
94* KDM2B_26808549_Chip-Seq_DND41_Human1.14992231
95THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.14542343
96* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.14531852
97TP63_17297297_ChIP-ChIP_HaCaT_Human1.14195514
98STAT3_1855785_ChIP-Seq_MESCs_Mouse1.13747175
99GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13673240
100* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13603920
101* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.13263426
102* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12075139
103IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.11950490
104* TCF7_22412390_ChIP-Seq_EML_Mouse1.11324983
105* KDM5A_27292631_Chip-Seq_BREAST_Human1.10340991
106CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09689134
107SRF_21415370_ChIP-Seq_HL-1_Mouse1.09510193
108HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08503820
109MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08472276
110CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.08364581
111CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08332157
112YY1_21170310_ChIP-Seq_MESCs_Mouse1.08246666
113GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06933003
114SPI1_23127762_ChIP-Seq_K562_Human1.06500682
115* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06088000
116E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05660185
117POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.05378174
118CTCF_26484167_Chip-Seq_Bcells_Mouse1.04832026
119LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04711639
120BP1_19119308_ChIP-ChIP_Hs578T_Human1.04546865
121DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.04284151
122PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03938313
123HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03818039
124KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03747339
125SA1_27219007_Chip-Seq_ERYTHROID_Human1.03727289
126STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.03071368
127* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.99991719
128SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99784205

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.12474530
2MP0003763_abnormal_thymus_physiology3.11540475
3MP0001835_abnormal_antigen_presentation2.90025518
4MP0005671_abnormal_response_to2.83576041
5MP0000685_abnormal_immune_system2.81724611
6MP0002396_abnormal_hematopoietic_system2.74174633
7MP0004957_abnormal_blastocyst_morpholog2.49307710
8MP0003436_decreased_susceptibility_to2.48339531
9MP0009333_abnormal_splenocyte_physiolog2.41561569
10MP0009785_altered_susceptibility_to2.37548830
11MP0001800_abnormal_humoral_immune2.30221127
12MP0002398_abnormal_bone_marrow2.25602634
13MP0003111_abnormal_nucleus_morphology2.18842768
14MP0003077_abnormal_cell_cycle2.18127706
15MP0005000_abnormal_immune_tolerance2.16383741
16MP0002420_abnormal_adaptive_immunity2.11899165
17MP0002452_abnormal_antigen_presenting2.10856037
18MP0001819_abnormal_immune_cell2.09857100
19MP0005025_abnormal_response_to2.08672240
20MP0002723_abnormal_immune_serum2.03629430
21MP0010352_gastrointestinal_tract_polyps2.03590600
22MP0010094_abnormal_chromosome_stability2.03250089
23MP0002405_respiratory_system_inflammati2.00771137
24MP0002877_abnormal_melanocyte_morpholog2.00057799
25MP0002722_abnormal_immune_system1.97834945
26MP0002166_altered_tumor_susceptibility1.95658826
27MP0005387_immune_system_phenotype1.94502096
28MP0001790_abnormal_immune_system1.94502096
29MP0005451_abnormal_body_composition1.92899735
30MP0000689_abnormal_spleen_morphology1.92376003
31MP0000490_abnormal_crypts_of1.91565704
32MP0000716_abnormal_immune_system1.90682236
33MP0004808_abnormal_hematopoietic_stem1.87826732
34MP0001853_heart_inflammation1.83375674
35MP0000703_abnormal_thymus_morphology1.82091595
36MP0005397_hematopoietic_system_phenotyp1.78993550
37MP0001545_abnormal_hematopoietic_system1.78993550
38MP0002429_abnormal_blood_cell1.76039399
39MP0002419_abnormal_innate_immunity1.69943645
40MP0008007_abnormal_cellular_replicative1.69516180
41MP0010155_abnormal_intestine_physiology1.68795727
42MP0003724_increased_susceptibility_to1.67579921
43MP0000858_altered_metastatic_potential1.67473845
44MP0001873_stomach_inflammation1.65275295
45MP0002006_tumorigenesis1.63545231
46MP0002148_abnormal_hypersensitivity_rea1.62697844
47MP0006082_CNS_inflammation1.59297873
48MP0005464_abnormal_platelet_physiology1.58129929
49MP0008057_abnormal_DNA_replication1.51614029
50MP0003303_peritoneal_inflammation1.49553948
51MP0006054_spinal_hemorrhage1.48759519
52MP0004947_skin_inflammation1.48137934
53MP0002933_joint_inflammation1.46986646
54MP0002019_abnormal_tumor_incidence1.43857222
55MP0005023_abnormal_wound_healing1.37951051
56MP0001845_abnormal_inflammatory_respons1.36853933
57MP0003300_gastrointestinal_ulcer1.36002354
58MP0008260_abnormal_autophagy1.34042513
59MP0009278_abnormal_bone_marrow1.31955332
60MP0003866_abnormal_defecation1.31789032
61MP0008058_abnormal_DNA_repair1.31485366
62MP0000465_gastrointestinal_hemorrhage1.27688069
63MP0001730_embryonic_growth_arrest1.24443501
64MP0003075_altered_response_to1.22200552
65MP0000350_abnormal_cell_proliferation1.20362319
66MP0002132_abnormal_respiratory_system1.17198803
67MP0008932_abnormal_embryonic_tissue1.16656174
68MP0010307_abnormal_tumor_latency1.16254556
69MP0003566_abnormal_cell_adhesion1.15216115
70MP0003448_altered_tumor_morphology1.13782075
71MP0000313_abnormal_cell_death1.12461169
72MP0008469_abnormal_protein_level1.04587841
73* MP0001533_abnormal_skeleton_physiology1.02622519
74MP0004185_abnormal_adipocyte_glucose1.00076416
75MP0002998_abnormal_bone_remodeling0.99963781
76MP0004510_myositis0.99058995
77MP0000343_altered_response_to0.96208457
78MP0009764_decreased_sensitivity_to0.94812595
79MP0005166_decreased_susceptibility_to0.94352911
80MP0009840_abnormal_foam_cell0.92999808
81MP0003806_abnormal_nucleotide_metabolis0.91796963
82MP0005075_abnormal_melanosome_morpholog0.91136200
83MP0003186_abnormal_redox_activity0.89233827
84* MP0002080_prenatal_lethality0.88019094
85MP0005076_abnormal_cell_differentiation0.87578066
86MP0000477_abnormal_intestine_morphology0.87444529
87MP0003705_abnormal_hypodermis_morpholog0.84078621
88MP0003279_aneurysm0.83732161
89MP0001697_abnormal_embryo_size0.83599049
90MP0004858_abnormal_nervous_system0.83066514
91MP0001542_abnormal_bone_strength0.83065990
92MP0003786_premature_aging0.82981930
93MP0005165_increased_susceptibility_to0.78768997
94MP0008438_abnormal_cutaneous_collagen0.78136722
95MP0005058_abnormal_lysosome_morphology0.78042520
96MP0002086_abnormal_extraembryonic_tissu0.76914218
97MP0001881_abnormal_mammary_gland0.74789732
98MP0001243_abnormal_dermal_layer0.74739735
99MP0003984_embryonic_growth_retardation0.74702448
100MP0005501_abnormal_skin_physiology0.73830632
101MP0005310_abnormal_salivary_gland0.73179683
102MP0005380_embryogenesis_phenotype0.72793969
103MP0001672_abnormal_embryogenesis/_devel0.72793969
104MP0005174_abnormal_tail_pigmentation0.72580600
105MP0000358_abnormal_cell_content/0.72506381
106MP0002088_abnormal_embryonic_growth/wei0.72252993
107* MP0005390_skeleton_phenotype0.71593774
108MP0003795_abnormal_bone_structure0.71261363
109MP0001849_ear_inflammation0.70812607
110MP0003453_abnormal_keratinocyte_physiol0.66268756
111MP0005623_abnormal_meninges_morphology0.63983327
112MP0009763_increased_sensitivity_to0.63891713
113MP0001851_eye_inflammation0.61200430
114MP0000598_abnormal_liver_morphology0.61176727
115MP0003567_abnormal_fetal_cardiomyocyte0.60944895
116MP0003172_abnormal_lysosome_physiology0.60866320
117MP0001915_intracranial_hemorrhage0.60320142
118MP0003191_abnormal_cellular_cholesterol0.58051446
119MP0005621_abnormal_cell_physiology0.57974020

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.32462858
2IgM deficiency (HP:0002850)4.24790390
3Eczematoid dermatitis (HP:0000976)4.01377274
4Abnormality of cells of the erythroid lineage (HP:0012130)3.70692106
5Abnormal number of erythroid precursors (HP:0012131)3.67972259
6Severe combined immunodeficiency (HP:0004430)3.58213237
7Combined immunodeficiency (HP:0005387)3.46963181
8Recurrent bronchitis (HP:0002837)3.45830724
9Recurrent abscess formation (HP:0002722)3.42920271
10Reticulocytopenia (HP:0001896)3.38070181
11T lymphocytopenia (HP:0005403)3.37497301
12Abnormality of T cells (HP:0002843)3.31821887
13Abnormality of T cell number (HP:0011839)3.29451458
14Recurrent fungal infections (HP:0002841)3.23293067
15Thrombocytosis (HP:0001894)3.20552753
16Petechiae (HP:0000967)3.19297316
17Chronic otitis media (HP:0000389)3.16645368
18Aplastic anemia (HP:0001915)3.07183509
19IgG deficiency (HP:0004315)2.96996820
20Abnormality of T cell physiology (HP:0011840)2.94851474
21Myositis (HP:0100614)2.94835247
22Pustule (HP:0200039)2.86834675
23Panhypogammaglobulinemia (HP:0003139)2.81548295
24Vertebral compression fractures (HP:0002953)2.79299671
25Recurrent viral infections (HP:0004429)2.76346331
26Hypertensive crisis (HP:0100735)2.76191462
27Abnormality of cells of the lymphoid lineage (HP:0012140)2.73706953
28Lymphopenia (HP:0001888)2.69661144
29Hepatosplenomegaly (HP:0001433)2.68892006
30Nasal polyposis (HP:0100582)2.67790998
31Recurrent bacterial skin infections (HP:0005406)2.64375484
32Recurrent cutaneous fungal infections (HP:0011370)2.55732977
33Chronic mucocutaneous candidiasis (HP:0002728)2.55732977
34Purpura (HP:0000979)2.55407212
35Abnormality of the nasal mucosa (HP:0000433)2.54591099
36Encephalitis (HP:0002383)2.52958466
37Lymphoma (HP:0002665)2.50921805
38Pallor (HP:0000980)2.50632599
39Mediastinal lymphadenopathy (HP:0100721)2.47673200
40Increased density of long bones (HP:0006392)2.45803372
41Leukocytosis (HP:0001974)2.44498734
42Selective tooth agenesis (HP:0001592)2.43790604
43Granulocytopenia (HP:0001913)2.42041964
44Abnormality of macrophages (HP:0004311)2.39022937
45Cellulitis (HP:0100658)2.38890823
46Trismus (HP:0000211)2.37680157
47Oral leukoplakia (HP:0002745)2.34883520
48Abnormality of glycolipid metabolism (HP:0010969)2.34366522
49Abnormality of liposaccharide metabolism (HP:0010968)2.34366522
50Abnormality of glycosphingolipid metabolism (HP:0004343)2.34366522
51Chest pain (HP:0100749)2.34137376
52Abnormality of eosinophils (HP:0001879)2.33720644
53Microretrognathia (HP:0000308)2.33227375
54Orchitis (HP:0100796)2.31686223
55Abnormality of B cell number (HP:0010975)2.30054799
56B lymphocytopenia (HP:0010976)2.30054799
57Chronic obstructive pulmonary disease (HP:0006510)2.29647497
58Obstructive lung disease (HP:0006536)2.29647497
59Macrocytic anemia (HP:0001972)2.27291938
60Recurrent skin infections (HP:0001581)2.26803838
61Centrally nucleated skeletal muscle fibers (HP:0003687)2.22718202
62Meningitis (HP:0001287)2.18918226
63Eosinophilia (HP:0001880)2.18505785
64Stomatitis (HP:0010280)2.17688748
65Skin rash (HP:0000988)2.15877025
66Autoimmune thrombocytopenia (HP:0001973)2.15265933
67Abnormal delayed hypersensitivity skin test (HP:0002963)2.14824107
68Ragged-red muscle fibers (HP:0003200)2.14249720
69Gastrointestinal infarctions (HP:0005244)2.12371330
70Recurrent gram-negative bacterial infections (HP:0005420)2.10583426
71Poor head control (HP:0002421)2.09329328
72Acute hepatic failure (HP:0006554)2.09127653
73Birth length less than 3rd percentile (HP:0003561)2.09074980
74Pulmonary infiltrates (HP:0002113)2.08969715
75Verrucae (HP:0200043)2.08564003
76Papilloma (HP:0012740)2.08564003
77Multiple enchondromatosis (HP:0005701)2.08028675
78Prolonged bleeding time (HP:0003010)2.07569557
79Thyroiditis (HP:0100646)2.07018101
80Gastrointestinal stroma tumor (HP:0100723)2.06473355
81Basal cell carcinoma (HP:0002671)2.05704428
82Abnormality of the prostate (HP:0008775)2.05118554
83Agammaglobulinemia (HP:0004432)2.04461909
84Spontaneous hematomas (HP:0007420)2.04063751
85Muscle fiber atrophy (HP:0100295)2.03931928
86Gastrointestinal inflammation (HP:0004386)2.01873412
87Sepsis (HP:0100806)2.01418229
88Degeneration of anterior horn cells (HP:0002398)1.99763223
89Abnormality of the anterior horn cell (HP:0006802)1.99763223
90Increased cerebral lipofuscin (HP:0011813)1.98447054
91IgA deficiency (HP:0002720)1.97504161
92Rough bone trabeculation (HP:0100670)1.95010862
93Hypoplasia of the thymus (HP:0000778)1.94867954
94Pancytopenia (HP:0001876)1.94700856
95Poikiloderma (HP:0001029)1.93202901
96Increased IgM level (HP:0003496)1.92865355
97Hypergammaglobulinemia (HP:0010702)1.92409764
98Progressive neurologic deterioration (HP:0002344)1.91949804
99Vasculitis (HP:0002633)1.91631141
100Increased neuronal autofluorescent lipopigment (HP:0002074)1.91513826
101Skin ulcer (HP:0200042)1.91463334
102Glomerulopathy (HP:0100820)1.90026732
103Inflammation of the large intestine (HP:0002037)1.89141406
104Aplasia/Hypoplasia of the thymus (HP:0010515)1.88100266
105Decreased activity of mitochondrial respiratory chain (HP:0008972)1.88039654
106Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.88039654
107Reduced subcutaneous adipose tissue (HP:0003758)1.85964995
108Interstitial pulmonary disease (HP:0006530)1.85365242
109Gastrointestinal dysmotility (HP:0002579)1.85008881
110Protrusio acetabuli (HP:0003179)1.84723819
111Bronchitis (HP:0012387)1.84661911
112Epistaxis (HP:0000421)1.84359799
113Autoimmune hemolytic anemia (HP:0001890)1.83817833
114Urticaria (HP:0001025)1.82619536
115Progressive muscle weakness (HP:0003323)1.82025630
116Recurrent lower respiratory tract infections (HP:0002783)1.81020584
11711 pairs of ribs (HP:0000878)1.80504653
118Colon cancer (HP:0003003)1.80234284
119Distal lower limb muscle weakness (HP:0009053)1.80116618
120Impaired platelet aggregation (HP:0003540)1.79623648
121Abnormal platelet function (HP:0011869)1.79623648
122Colitis (HP:0002583)1.79188924
123Microvesicular hepatic steatosis (HP:0001414)1.78955477
124Optic neuritis (HP:0100653)1.78476545
125Retrobulbar optic neuritis (HP:0100654)1.78476545
126Microcytic anemia (HP:0001935)1.78040206
127Increased serum ferritin (HP:0003281)1.77836598
128Pulmonary fibrosis (HP:0002206)1.77622671
129Abnormality of iron homeostasis (HP:0011031)1.77163974
130Chronic diarrhea (HP:0002028)1.76508156
131Premature graying of hair (HP:0002216)1.76453690
132Osteomyelitis (HP:0002754)1.75588443
133Hypertriglyceridemia (HP:0002155)1.75214092
134Type 2 muscle fiber atrophy (HP:0003554)1.75077450
135Abnormal platelet volume (HP:0011876)1.74375930
136Increased IgE level (HP:0003212)1.73536455
137Cellular immunodeficiency (HP:0005374)1.73320838
138Entropion (HP:0000621)1.72708889

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK24.19755201
2MAP4K13.90000481
3VRK23.41567763
4BUB12.99196895
5NME22.85917292
6TESK12.50937629
7SMG12.42253211
8ZAP702.41060560
9BLK2.16907054
10TXK2.12529478
11WEE12.09934218
12STK102.07552400
13EIF2AK12.05301309
14RPS6KA41.90745470
15PIM21.87115340
16PRPF4B1.83234878
17BCKDK1.82101615
18LRRK21.79585485
19MAP3K101.77771440
20JAK31.77166557
21ERN11.77053454
22TRIB31.71221494
23CDC71.66265774
24RIPK41.62837693
25SCYL21.62022326
26TBK11.59640325
27EEF2K1.56814159
28TYK21.55559448
29NEK21.55547236
30BTK1.55180776
31ARAF1.53119660
32PKN21.49351694
33MAP3K111.43064685
34PAK41.36432438
35KIT1.33737625
36GRK61.32360852
37ACVR1B1.30526664
38LIMK11.29639577
39IKBKE1.28926961
40IRAK41.26257096
41RPS6KB21.23828936
42MAP2K31.20124483
43EIF2AK31.19389871
44FES1.19051704
45STK161.18304211
46MAP3K81.16495237
47TEC1.16368554
48ITK1.10864814
49TGFBR11.10230478
50FLT31.05687307
51LCK1.04945608
52MAPKAPK31.01227691
53CDK70.99853525
54TLK10.99557518
55PIM10.99287387
56SYK0.99020207
57CSF1R0.95503576
58CDK40.94169929
59DAPK10.92598108
60ILK0.88942849
61AURKB0.88717696
62CSK0.83572509
63IKBKB0.83172128
64MAP3K130.83079257
65FGFR40.81074925
66TSSK60.80728136
67PLK40.79887363
68NLK0.79339376
69LYN0.79070444
70DYRK30.78063591
71STK40.74767845
72ATR0.73609059
73HCK0.72871070
74TTN0.72662727
75VRK10.72455152
76EPHA20.72265100
77MST40.72177854
78IRAK30.69732132
79SRPK10.67077982
80TGFBR20.66603818
81EPHB10.65701083
82ABL20.65150794
83PLK10.64777074
84PASK0.63213126
85MOS0.62715574
86SIK10.60456470
87TNK20.60374295
88MAP3K10.59102388
89CLK10.57928008
90BRSK20.56797466
91PAK10.56086547
92CDK120.54320817
93SIK30.53146963
94JAK10.51716214
95MAP3K140.50798775
96TAOK30.50699963
97GRK70.50551226
98PRKG20.50462716
99AURKA0.50424776
100TAOK10.49973453
101MAPKAPK20.49679855
102MAP2K20.48526368
103CDK80.48509755
104PRKCQ0.47781058
105MAP3K30.46917169
106CHUK0.46787753
107TTK0.45648934
108MARK30.45101186
109MAP3K120.43841629
110BMX0.43093974
111ICK0.41820559
112NEK90.41736229
113MYLK0.41179409
114CDK60.39290724
115MATK0.39241215
116RPS6KA50.38896046
117NEK10.37585905
118FGR0.35106858
119DAPK30.34311906
120PTK60.34052069
121MAPK110.33591075
122HIPK20.32692032
123CDC42BPA0.32515927
124BRAF0.32142565
125CHEK10.32068286
126PRKD20.31620802
127PAK20.30917833
128TAOK20.30112140
129MKNK10.30000286
130FYN0.28727811
131MST1R0.28404183

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.90037013
2Ribosome_Homo sapiens_hsa030103.46391340
3Proteasome_Homo sapiens_hsa030503.21119573
4Primary immunodeficiency_Homo sapiens_hsa053402.93294804
5Mismatch repair_Homo sapiens_hsa034302.86740650
6Spliceosome_Homo sapiens_hsa030402.48224631
7Base excision repair_Homo sapiens_hsa034102.29678905
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.18580650
9RNA polymerase_Homo sapiens_hsa030202.04350779
10Nucleotide excision repair_Homo sapiens_hsa034201.94297656
11Antigen processing and presentation_Homo sapiens_hsa046121.93353271
12Homologous recombination_Homo sapiens_hsa034401.89202106
13RNA transport_Homo sapiens_hsa030131.82922128
14Pyrimidine metabolism_Homo sapiens_hsa002401.82127235
15Type I diabetes mellitus_Homo sapiens_hsa049401.81655631
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.81630809
17Leishmaniasis_Homo sapiens_hsa051401.63407765
18Cell cycle_Homo sapiens_hsa041101.63189689
19Measles_Homo sapiens_hsa051621.61653949
20p53 signaling pathway_Homo sapiens_hsa041151.48967932
21One carbon pool by folate_Homo sapiens_hsa006701.48842477
22NF-kappa B signaling pathway_Homo sapiens_hsa040641.48218227
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.47693414
24Hematopoietic cell lineage_Homo sapiens_hsa046401.45897955
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.44197331
26Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.43202494
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.41100243
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.38722167
29Herpes simplex infection_Homo sapiens_hsa051681.37814980
30* Shigellosis_Homo sapiens_hsa051311.32484158
31T cell receptor signaling pathway_Homo sapiens_hsa046601.31453567
32Epstein-Barr virus infection_Homo sapiens_hsa051691.24852908
33Legionellosis_Homo sapiens_hsa051341.23721251
34Viral myocarditis_Homo sapiens_hsa054161.22584310
35Rheumatoid arthritis_Homo sapiens_hsa053231.18881667
36Allograft rejection_Homo sapiens_hsa053301.17954155
37RNA degradation_Homo sapiens_hsa030181.17756306
38B cell receptor signaling pathway_Homo sapiens_hsa046621.15803272
39Apoptosis_Homo sapiens_hsa042101.11698992
40Pentose phosphate pathway_Homo sapiens_hsa000301.10578702
41Non-homologous end-joining_Homo sapiens_hsa034501.09879537
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08924078
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05673899
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05168310
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.02279569
46Viral carcinogenesis_Homo sapiens_hsa052031.01762765
47HTLV-I infection_Homo sapiens_hsa051661.00428449
48Osteoclast differentiation_Homo sapiens_hsa043800.99027984
49Graft-versus-host disease_Homo sapiens_hsa053320.98103366
50Acute myeloid leukemia_Homo sapiens_hsa052210.93340308
51Fanconi anemia pathway_Homo sapiens_hsa034600.90997660
52Sulfur relay system_Homo sapiens_hsa041220.90398620
53Hepatitis B_Homo sapiens_hsa051610.89983596
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89925693
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.86950130
56Asthma_Homo sapiens_hsa053100.84102837
57Fructose and mannose metabolism_Homo sapiens_hsa000510.83316138
58Toxoplasmosis_Homo sapiens_hsa051450.81583950
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80742074
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79793006
61Pertussis_Homo sapiens_hsa051330.77594401
62Influenza A_Homo sapiens_hsa051640.77390113
63Other glycan degradation_Homo sapiens_hsa005110.76369587
64Lysosome_Homo sapiens_hsa041420.75750621
65Phagosome_Homo sapiens_hsa041450.75361477
66Malaria_Homo sapiens_hsa051440.74151760
67Small cell lung cancer_Homo sapiens_hsa052220.73136167
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72540253
69Chronic myeloid leukemia_Homo sapiens_hsa052200.72253319
70Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72087630
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71417505
72Basal transcription factors_Homo sapiens_hsa030220.70999044
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70461604
74Systemic lupus erythematosus_Homo sapiens_hsa053220.70023904
75Thyroid cancer_Homo sapiens_hsa052160.69945368
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69290984
77Purine metabolism_Homo sapiens_hsa002300.68214417
78mRNA surveillance pathway_Homo sapiens_hsa030150.67482730
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65717878
80Endocytosis_Homo sapiens_hsa041440.63325071
81Protein export_Homo sapiens_hsa030600.62530695
82Tuberculosis_Homo sapiens_hsa051520.61970874
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60643523
84* Salmonella infection_Homo sapiens_hsa051320.60625651
85Non-small cell lung cancer_Homo sapiens_hsa052230.60519434
86Parkinsons disease_Homo sapiens_hsa050120.59858079
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59437488
88Folate biosynthesis_Homo sapiens_hsa007900.59311836
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59104143
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58504508
91TNF signaling pathway_Homo sapiens_hsa046680.55961722
92Carbon metabolism_Homo sapiens_hsa012000.55088649
93Platelet activation_Homo sapiens_hsa046110.54768386
94Colorectal cancer_Homo sapiens_hsa052100.54142280
95Pancreatic cancer_Homo sapiens_hsa052120.53258454
96N-Glycan biosynthesis_Homo sapiens_hsa005100.53144292
97Hepatitis C_Homo sapiens_hsa051600.52979928
98Autoimmune thyroid disease_Homo sapiens_hsa053200.52547472
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51868418
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51465048
101Oxidative phosphorylation_Homo sapiens_hsa001900.48277320
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47912351
103Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47129141
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45363661
105Central carbon metabolism in cancer_Homo sapiens_hsa052300.45000309
106African trypanosomiasis_Homo sapiens_hsa051430.44300032
107Prion diseases_Homo sapiens_hsa050200.44086901
108Drug metabolism - other enzymes_Homo sapiens_hsa009830.43641187
109Staphylococcus aureus infection_Homo sapiens_hsa051500.42808632
110Bladder cancer_Homo sapiens_hsa052190.42807246
111Chemokine signaling pathway_Homo sapiens_hsa040620.42282508
112HIF-1 signaling pathway_Homo sapiens_hsa040660.41870804
113VEGF signaling pathway_Homo sapiens_hsa043700.40402069
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39735799
115Glycosaminoglycan degradation_Homo sapiens_hsa005310.39579635
116Biosynthesis of amino acids_Homo sapiens_hsa012300.38515265
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36700647
118Galactose metabolism_Homo sapiens_hsa000520.36426069
119Glutathione metabolism_Homo sapiens_hsa004800.36236031
120Selenocompound metabolism_Homo sapiens_hsa004500.34977322
121* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34211375
122MicroRNAs in cancer_Homo sapiens_hsa052060.33919173
123Caffeine metabolism_Homo sapiens_hsa002320.33820734
124Notch signaling pathway_Homo sapiens_hsa043300.33541626

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