PFN1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine metabolic process (GO:0046087)9.19357676
2cytidine catabolic process (GO:0006216)9.19357676
3cytidine deamination (GO:0009972)9.19357676
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450918.79499038
5DNA deamination (GO:0045006)8.37988184
6pyrimidine ribonucleoside catabolic process (GO:0046133)8.19709811
7Arp2/3 complex-mediated actin nucleation (GO:0034314)5.51425069
8regulation of activation of Janus kinase activity (GO:0010533)5.15762899
9actin nucleation (GO:0045010)5.04968176
10positive T cell selection (GO:0043368)5.02594878
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.90238982
12cellular response to interleukin-15 (GO:0071350)4.84703085
13positive thymic T cell selection (GO:0045059)4.84449264
14negative T cell selection (GO:0043383)4.67230060
15T cell migration (GO:0072678)4.63905414
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.60966298
17negative regulation of T cell apoptotic process (GO:0070233)4.49669640
18negative regulation by host of viral transcription (GO:0043922)4.42593794
19positive regulation of calcium-mediated signaling (GO:0050850)4.38154156
20regulation of B cell receptor signaling pathway (GO:0050855)4.28004076
21sequestering of actin monomers (GO:0042989)4.23166435
22positive regulation of natural killer cell mediated immunity (GO:0002717)4.22457300
23positive regulation of interleukin-8 secretion (GO:2000484)4.22107566
24positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.16750448
25eosinophil chemotaxis (GO:0048245)4.13918161
26cytolysis (GO:0019835)4.04929112
27pyrimidine nucleoside catabolic process (GO:0046135)4.04537125
28positive regulation of gamma-delta T cell activation (GO:0046645)4.03268269
29regulation of regulatory T cell differentiation (GO:0045589)4.01291248
30negative regulation of viral genome replication (GO:0045071)3.96270413
31regulation of T cell tolerance induction (GO:0002664)3.91694597
32regulation of T cell receptor signaling pathway (GO:0050856)3.89487927
33positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.88967370
34positive regulation of tolerance induction (GO:0002645)3.86577774
35response to interleukin-15 (GO:0070672)3.77512568
36eosinophil migration (GO:0072677)3.76847879
37thymic T cell selection (GO:0045061)3.70886825
38regulation of lymphocyte chemotaxis (GO:1901623)3.68541670
39regulation of natural killer cell mediated immunity (GO:0002715)3.68219771
40regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.68219771
41T cell receptor signaling pathway (GO:0050852)3.67462103
42negative thymic T cell selection (GO:0045060)3.63191697
43positive regulation of monocyte chemotaxis (GO:0090026)3.61471205
44regulation of chronic inflammatory response (GO:0002676)3.60724979
45regulation of leukocyte mediated cytotoxicity (GO:0001910)3.60323456
46regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.59604511
47positive regulation of T cell chemotaxis (GO:0010820)3.59096297
48regulation of T cell chemotaxis (GO:0010819)3.59096297
49macrophage chemotaxis (GO:0048246)3.56733510
50T cell selection (GO:0045058)3.56113414
51regulation of interleukin-8 secretion (GO:2000482)3.55146018
52T cell costimulation (GO:0031295)3.46640593
53regulation of gamma-delta T cell differentiation (GO:0045586)3.45885477
54lymphocyte costimulation (GO:0031294)3.42435758
55positive regulation of cell killing (GO:0031343)3.40694515
56positive regulation of T cell mediated cytotoxicity (GO:0001916)3.40221654
57positive regulation of alpha-beta T cell proliferation (GO:0046641)3.36306925
58interferon-gamma production (GO:0032609)3.35912660
59positive regulation of defense response to virus by host (GO:0002230)3.35861297
60regulation of tolerance induction (GO:0002643)3.32712616
61regulation of B cell differentiation (GO:0045577)3.29093350
62cellular defense response (GO:0006968)3.27307328
63regulation of T cell mediated cytotoxicity (GO:0001914)3.25299289
64negative regulation of lymphocyte apoptotic process (GO:0070229)3.23852355
65regulation of cell killing (GO:0031341)3.21355602
66negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.21109409
67antigen receptor-mediated signaling pathway (GO:0050851)3.20384394
68lymphocyte chemotaxis (GO:0048247)3.20259265
69regulation of calcium-mediated signaling (GO:0050848)3.18362829
70regulation of alpha-beta T cell proliferation (GO:0046640)3.17883806
71positive regulation of lymphocyte migration (GO:2000403)3.11562598
72antigen processing and presentation via MHC class Ib (GO:0002475)3.09344701
73positive regulation of B cell differentiation (GO:0045579)3.05804045
74regulation of T cell apoptotic process (GO:0070232)3.04433089
75positive regulation of interleukin-4 production (GO:0032753)3.01449354
76regulation of gamma-delta T cell activation (GO:0046643)2.95072466
77regulation of viral genome replication (GO:0045069)2.94864505
78positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.91113759
79monocyte chemotaxis (GO:0002548)2.89506271
80lymphocyte migration (GO:0072676)2.89398992
81dendritic cell chemotaxis (GO:0002407)2.88281188
82negative regulation of cell killing (GO:0031342)2.80906318
83negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.80906318
84ATP synthesis coupled proton transport (GO:0015986)2.80075202
85energy coupled proton transport, down electrochemical gradient (GO:0015985)2.80075202
86response to interferon-beta (GO:0035456)2.78558867
87mast cell activation (GO:0045576)2.78001781
88negative regulation of stress fiber assembly (GO:0051497)2.77190385
89antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.75621471
90positive regulation of T cell apoptotic process (GO:0070234)2.75508761
91protein neddylation (GO:0045116)2.73825097
92negative regulation of T cell receptor signaling pathway (GO:0050860)2.73076533
93positive regulation of interleukin-1 beta secretion (GO:0050718)2.72870332
94positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.65167087
95mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.64316563
96positive regulation of uterine smooth muscle contraction (GO:0070474)2.63664228
97immunoglobulin mediated immune response (GO:0016064)2.62809138
98antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.62741566
99chemokine-mediated signaling pathway (GO:0070098)2.62645049
100regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.58590206

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.49570658
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.48167584
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.31320488
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.21080094
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.34285370
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.29437191
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.25060950
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.15079095
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.99271816
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.96123314
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.89350579
12MYB_26560356_Chip-Seq_TH2_Human2.65964020
13STAT4_19710469_ChIP-ChIP_TH1__Mouse2.41077710
14RUNX_20019798_ChIP-Seq_JUKART_Human2.25579360
15VDR_22108803_ChIP-Seq_LS180_Human2.23545806
16RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.23221011
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.08716374
18GATA3_27048872_Chip-Seq_THYMUS_Human2.06212548
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.94446631
20GATA3_26560356_Chip-Seq_TH2_Human1.80377442
21LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.80178936
22STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.78825288
23EST1_17652178_ChIP-ChIP_JURKAT_Human1.77984832
24MYB_26560356_Chip-Seq_TH1_Human1.75957109
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.71750107
26VDR_23849224_ChIP-Seq_CD4+_Human1.71537855
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67491820
28UTX_26944678_Chip-Seq_JUKART_Human1.65517837
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.63788666
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.63250383
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55881402
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45795402
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.44458820
34JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.43865853
35HTT_18923047_ChIP-ChIP_STHdh_Human1.41402420
36PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.37589088
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.33241616
38TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.33029476
39RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.31032240
40SPI1_23547873_ChIP-Seq_NB4_Human1.28925053
41MAF_26560356_Chip-Seq_TH2_Human1.28108228
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.27204528
43RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.26549171
44IGF1R_20145208_ChIP-Seq_DFB_Human1.24742415
45MAF_26560356_Chip-Seq_TH1_Human1.23730679
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23206450
47TAF2_19829295_ChIP-Seq_ESCs_Human1.19810795
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.19396342
49MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19126697
50GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18356266
51EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.17979604
52FOXP3_21729870_ChIP-Seq_TREG_Human1.16777528
53CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16717468
54BCL6_27268052_Chip-Seq_Bcells_Human1.16280877
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.15207884
56MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.14453710
57NANOG_20526341_ChIP-Seq_ESCs_Human1.11857432
58AR_20517297_ChIP-Seq_VCAP_Human1.10900939
59TP53_22573176_ChIP-Seq_HFKS_Human1.10749227
60ZNF274_21170338_ChIP-Seq_K562_Hela1.10479394
61LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.10444847
62PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.07763424
63CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.06957336
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03563582
65ETS1_20019798_ChIP-Seq_JURKAT_Human1.03250532
66EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01978730
67FOXA1_25329375_ChIP-Seq_VCAP_Human1.00066501
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00066501
69YY1_22570637_ChIP-Seq_MALME-3M_Human0.99806964
70GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.99481517
71NCOR_22424771_ChIP-Seq_293T_Human0.97165297
72AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96541078
73IRF8_27001747_Chip-Seq_BMDM_Mouse0.96483953
74CIITA_25753668_ChIP-Seq_RAJI_Human0.94693589
75GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.94302250
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93999011
77STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92008752
78P300_27268052_Chip-Seq_Bcells_Human0.91928536
79MYC_19829295_ChIP-Seq_ESCs_Human0.91247826
80FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91156843
81GATA3_26560356_Chip-Seq_TH1_Human0.89745016
82EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.89712272
83RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.88792540
84CTCF_20526341_ChIP-Seq_ESCs_Human0.88745300
85FOXA1_21572438_ChIP-Seq_LNCaP_Human0.88531285
86FOXH1_21741376_ChIP-Seq_EPCs_Human0.88015376
87STAT1_20625510_ChIP-Seq_HELA_Human0.87468771
88GATA6_21074721_ChIP-Seq_CACO-2_Human0.85708530
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.85095002
90ELK1_19687146_ChIP-ChIP_HELA_Human0.84965992
91GATA3_21878914_ChIP-Seq_MCF-7_Human0.84503999
92NANOG_19829295_ChIP-Seq_ESCs_Human0.84111352
93SOX2_19829295_ChIP-Seq_ESCs_Human0.84111352
94ELF1_20517297_ChIP-Seq_JURKAT_Human0.83747085
95PCGF2_27294783_Chip-Seq_NPCs_Mouse0.82818488
96ERG_20517297_ChIP-Seq_VCAP_Human0.82754934
97TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.82700176
98CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.82571555
99HOXB4_20404135_ChIP-ChIP_EML_Mouse0.82215289
100NFE2_27457419_Chip-Seq_LIVER_Mouse0.81595385

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.71785149
2MP0009785_altered_susceptibility_to3.81979301
3MP0001835_abnormal_antigen_presentation3.63261798
4MP0003763_abnormal_thymus_physiology3.25155749
5MP0005000_abnormal_immune_tolerance3.02703959
6MP0001800_abnormal_humoral_immune2.67925969
7MP0009333_abnormal_splenocyte_physiolog2.60262589
8MP0002148_abnormal_hypersensitivity_rea2.56861233
9MP0002723_abnormal_immune_serum2.56052876
10MP0002420_abnormal_adaptive_immunity2.49757168
11MP0005025_abnormal_response_to2.48078736
12MP0003866_abnormal_defecation2.47730929
13MP0000685_abnormal_immune_system2.44784037
14MP0001819_abnormal_immune_cell2.43871222
15MP0002166_altered_tumor_susceptibility2.43468529
16MP0005387_immune_system_phenotype2.32822750
17MP0001790_abnormal_immune_system2.32822750
18MP0006082_CNS_inflammation2.23167854
19MP0002452_abnormal_antigen_presenting2.12306142
20MP0003436_decreased_susceptibility_to2.11002881
21MP0005645_abnormal_hypothalamus_physiol1.95777313
22MP0006072_abnormal_retinal_apoptosis1.88309780
23MP0002006_tumorigenesis1.86876342
24MP0003724_increased_susceptibility_to1.86072082
25MP0000716_abnormal_immune_system1.85432168
26MP0002398_abnormal_bone_marrow1.84714934
27MP0001873_stomach_inflammation1.82936227
28MP0010155_abnormal_intestine_physiology1.75688045
29MP0002405_respiratory_system_inflammati1.73929572
30MP0002419_abnormal_innate_immunity1.71736556
31MP0002933_joint_inflammation1.66420233
32MP0000703_abnormal_thymus_morphology1.62246917
33MP0002722_abnormal_immune_system1.59140534
34MP0001845_abnormal_inflammatory_respons1.57174031
35MP0002102_abnormal_ear_morphology1.56606935
36MP0000689_abnormal_spleen_morphology1.55715061
37MP0004145_abnormal_muscle_electrophysio1.46783153
38MP0003448_altered_tumor_morphology1.41260828
39MP0004947_skin_inflammation1.40747145
40MP0002429_abnormal_blood_cell1.39573211
41MP0003045_fibrosis1.38287322
42MP0001905_abnormal_dopamine_level1.33125435
43MP0001533_abnormal_skeleton_physiology1.32836268
44MP0002876_abnormal_thyroid_physiology1.29559743
45MP0001542_abnormal_bone_strength1.26923811
46MP0009764_decreased_sensitivity_to1.20882057
47MP0002638_abnormal_pupillary_reflex1.19166705
48MP0003646_muscle_fatigue1.18509249
49MP0008469_abnormal_protein_level1.18487250
50MP0003786_premature_aging1.17650172
51MP0005464_abnormal_platelet_physiology1.16362283
52MP0003011_delayed_dark_adaptation1.16203163
53MP0008995_early_reproductive_senescence1.08205001
54MP0004147_increased_porphyrin_level1.05256587
55MP0009763_increased_sensitivity_to1.04569389
56MP0002277_abnormal_respiratory_mucosa1.00978359
57MP0005075_abnormal_melanosome_morpholog1.00564856
58MP0003806_abnormal_nucleotide_metabolis1.00376865
59MP0008872_abnormal_physiological_respon0.98174541
60MP0001919_abnormal_reproductive_system0.97041440
61MP0001853_heart_inflammation0.96048691
62MP0005377_hearing/vestibular/ear_phenot0.95842908
63MP0003878_abnormal_ear_physiology0.95842908
64MP0002693_abnormal_pancreas_physiology0.92015220
65MP0003195_calcinosis0.91687642
66MP0002837_dystrophic_cardiac_calcinosis0.91661558
67MP0005253_abnormal_eye_physiology0.91434017
68MP0005551_abnormal_eye_electrophysiolog0.91097570
69MP0001968_abnormal_touch/_nociception0.90549820
70MP0002095_abnormal_skin_pigmentation0.87180006
71MP0005084_abnormal_gallbladder_morpholo0.86366664
72MP0003137_abnormal_impulse_conducting0.85912125
73MP0001501_abnormal_sleep_pattern0.83880527
74MP0001765_abnormal_ion_homeostasis0.79289255
75MP0004381_abnormal_hair_follicle0.78078494
76MP0005166_decreased_susceptibility_to0.76659662
77MP0003075_altered_response_to0.76605930
78MP0000858_altered_metastatic_potential0.76375875
79MP0005636_abnormal_mineral_homeostasis0.76225919
80MP0008875_abnormal_xenobiotic_pharmacok0.75688775
81MP0004142_abnormal_muscle_tone0.74649302
82MP0009379_abnormal_foot_pigmentation0.74236452
83MP0005389_reproductive_system_phenotype0.71730789
84MP0000372_irregular_coat_pigmentation0.71565636
85MP0002019_abnormal_tumor_incidence0.70921633
86MP0001485_abnormal_pinna_reflex0.69900537
87MP0004885_abnormal_endolymph0.69044619
88MP0002736_abnormal_nociception_after0.68657520
89MP0002138_abnormal_hepatobiliary_system0.66086962
90MP0002163_abnormal_gland_morphology0.64409217
91MP0008877_abnormal_DNA_methylation0.61817132
92MP0008873_increased_physiological_sensi0.61781766
93MP0002733_abnormal_thermal_nociception0.60795756
94MP0002234_abnormal_pharynx_morphology0.59141822
95MP0005390_skeleton_phenotype0.57355819
96MP0003880_abnormal_central_pattern0.57072313
97MP0009643_abnormal_urine_homeostasis0.56697372
98MP0001243_abnormal_dermal_layer0.55976163
99MP0001661_extended_life_span0.55692895
100MP0004742_abnormal_vestibular_system0.55211047

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)6.19773599
2Abnormality of T cell number (HP:0011839)5.82429288
3Elevated erythrocyte sedimentation rate (HP:0003565)5.62932732
4Aplastic anemia (HP:0001915)5.19542218
5IgG deficiency (HP:0004315)5.17110465
6Severe combined immunodeficiency (HP:0004430)4.71731297
7Hypoproteinemia (HP:0003075)4.26515502
8Abnormality of T cells (HP:0002843)3.98836624
9Increased IgM level (HP:0003496)3.80550416
10Autoimmune hemolytic anemia (HP:0001890)3.69062545
11Combined immunodeficiency (HP:0005387)3.67977353
12Thyroiditis (HP:0100646)3.51222454
13Abnormality of eosinophils (HP:0001879)3.49552481
14Congenital stationary night blindness (HP:0007642)3.36668776
15Abnormality of B cell number (HP:0010975)3.30968037
16Abnormality of the prostate (HP:0008775)3.30687141
17Stomatitis (HP:0010280)3.28475058
18Chronic diarrhea (HP:0002028)3.20038249
19Mitochondrial inheritance (HP:0001427)3.06722530
20Eosinophilia (HP:0001880)2.92875333
21B lymphocytopenia (HP:0010976)2.87066846
223-Methylglutaconic aciduria (HP:0003535)2.83915023
23Decreased activity of mitochondrial respiratory chain (HP:0008972)2.78319992
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.78319992
25Hepatocellular necrosis (HP:0001404)2.76772615
26Leukocytosis (HP:0001974)2.74200468
27Encephalitis (HP:0002383)2.68595101
28Absent rod-and cone-mediated responses on ERG (HP:0007688)2.67834108
29IgM deficiency (HP:0002850)2.64817950
30Myositis (HP:0100614)2.64404374
31Increased intramyocellular lipid droplets (HP:0012240)2.62734040
32Hepatic necrosis (HP:0002605)2.55984522
33Increased CSF lactate (HP:0002490)2.55723660
34Acute necrotizing encephalopathy (HP:0006965)2.55419534
35Meningitis (HP:0001287)2.54091098
36Recurrent bronchitis (HP:0002837)2.52795097
37Methylmalonic acidemia (HP:0002912)2.49995459
38Decreased electroretinogram (ERG) amplitude (HP:0000654)2.49787406
39Abnormal delayed hypersensitivity skin test (HP:0002963)2.49625659
40Amyotrophic lateral sclerosis (HP:0007354)2.46922823
41Abnormality of macrophages (HP:0004311)2.44977680
42Abnormal mitochondria in muscle tissue (HP:0008316)2.44518354
43Renal cortical cysts (HP:0000803)2.44082604
44Recurrent cutaneous fungal infections (HP:0011370)2.41678562
45Chronic mucocutaneous candidiasis (HP:0002728)2.41678562
46Pancytopenia (HP:0001876)2.40466967
47Granulocytopenia (HP:0001913)2.39788798
48Increased hepatocellular lipid droplets (HP:0006565)2.36767210
49Lymphopenia (HP:0001888)2.35467645
50Pulmonary infiltrates (HP:0002113)2.35225962
51Autoimmune thrombocytopenia (HP:0001973)2.34176434
52Joint swelling (HP:0001386)2.32283925
53Hypoalbuminemia (HP:0003073)2.31614466
54Abnormal albumin level (HP:0012116)2.31614466
55Hemiplegia (HP:0002301)2.30513694
56Chronic obstructive pulmonary disease (HP:0006510)2.29282484
57Obstructive lung disease (HP:0006536)2.29282484
58Abnormal rod and cone electroretinograms (HP:0008323)2.27400184
59Renal Fanconi syndrome (HP:0001994)2.25368648
60Abnormality of cells of the lymphoid lineage (HP:0012140)2.25345933
61Abnormality of T cell physiology (HP:0011840)2.23600419
62Vasculitis (HP:0002633)2.22533794
63Pustule (HP:0200039)2.22115084
64Lipid accumulation in hepatocytes (HP:0006561)2.21251836
65Increased muscle lipid content (HP:0009058)2.21148328
66Acute hepatic failure (HP:0006554)2.21053913
67Retrobulbar optic neuritis (HP:0100654)2.18464028
68Optic neuritis (HP:0100653)2.18464028
69Gangrene (HP:0100758)2.16562094
70Hypergammaglobulinemia (HP:0010702)2.16229932
71Stomach cancer (HP:0012126)2.14136516
72Generalized aminoaciduria (HP:0002909)2.11073189
73Recurrent fungal infections (HP:0002841)2.10329526
74Progressive macrocephaly (HP:0004481)2.10219895
75Pancreatic cysts (HP:0001737)2.09280344
76Attenuation of retinal blood vessels (HP:0007843)2.06881015
77Orchitis (HP:0100796)2.05144930
78Abnormality of the pleura (HP:0002103)2.04451341
79Methylmalonic aciduria (HP:0012120)2.02874365
80Mediastinal lymphadenopathy (HP:0100721)2.00870511
81Abnormality of the phalanges of the 2nd finger (HP:0009541)1.99673233
82Hemoptysis (HP:0002105)1.98137340
83Agammaglobulinemia (HP:0004432)1.97581183
84Chest pain (HP:0100749)1.94574436
85Acute encephalopathy (HP:0006846)1.93309344
86Abolished electroretinogram (ERG) (HP:0000550)1.92599753
87Abnormality of the renal cortex (HP:0011035)1.91735203
88Gastrointestinal infarctions (HP:0005244)1.91362156
89Dicarboxylic aciduria (HP:0003215)1.91346615
90Abnormality of dicarboxylic acid metabolism (HP:0010995)1.91346615
91Abnormality of midbrain morphology (HP:0002418)1.89121427
92Molar tooth sign on MRI (HP:0002419)1.89121427
93Recurrent viral infections (HP:0004429)1.87774674
94Ureteral stenosis (HP:0000071)1.86600793
95Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.86046142
96Increased serum lactate (HP:0002151)1.85579580
97Severe visual impairment (HP:0001141)1.84065669
98Pigmentary retinal degeneration (HP:0001146)1.82975300
99Lymphoma (HP:0002665)1.82556898
100Decreased central vision (HP:0007663)1.81884362

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR6.35187454
2TXK6.14938736
3TESK25.27803810
4MAP4K12.81333139
5BCKDK2.71634622
6ITK2.32411030
7TAOK32.22284282
8TESK12.14891912
9TLK12.06927224
10ZAK1.90758489
11LIMK11.86767037
12ADRBK21.83355080
13VRK21.83162552
14SYK1.72286777
15WNK41.58715318
16GRK61.56477658
17FES1.56177468
18MAP3K121.51478501
19SCYL21.51439159
20GRK11.48679924
21GRK71.48166727
22PRKCQ1.46311148
23LCK1.45098876
24CSF1R1.38636555
25CSK1.37415435
26MAP4K21.36216465
27TEC1.34751586
28KIT1.33510084
29ZAP701.31283763
30MST41.22725324
31BTK1.22396976
32IKBKB1.20775810
33IKBKE1.14925111
34TBK11.13335974
35PASK1.05765911
36LYN1.04770589
37NUAK11.02048158
38MAP2K60.99578043
39MAPKAPK30.98833940
40MAP2K20.98378524
41MUSK0.98235724
42MAP3K110.94430211
43JAK30.93844173
44FRK0.93456439
45PINK10.93437538
46MAP3K140.90787856
47FLT30.90356188
48VRK10.88220986
49INSRR0.83247970
50STK160.80759608
51PIK3CG0.80715863
52PIK3CA0.80294721
53TIE10.76597278
54MYLK0.75482712
55CAMKK20.72975984
56BUB10.71180434
57BLK0.61822549
58FYN0.59938847
59PIM10.59605717
60RPS6KA50.58635600
61OBSCN0.58558850
62IGF1R0.57145723
63DAPK10.56422963
64ROCK10.54376694
65OXSR10.53795517
66TRPM70.52958160
67ADRBK10.47907281
68HCK0.44335135
69CAMKK10.42944730
70INSR0.42460747
71NME10.41060977
72STK390.41040988
73MATK0.40648432
74PRKCA0.40258500
75STK100.38723492
76AURKA0.37402115
77RIPK40.36878557
78DAPK20.33632242
79GRK50.32798899
80WNK30.32386847
81TGFBR20.30592670
82PIM20.30583262
83RPS6KA40.30259398
84TNK20.29716903
85ABL10.29679661
86PRKACA0.29486266
87JAK20.26887304
88BMPR20.26833505
89ERBB30.26086204
90EGFR0.23267255
91CDK80.21555558
92PHKG10.21480597
93PHKG20.21480597
94ATR0.21091323
95CSNK2A10.19940219
96PAK10.19128490
97CAMK2A0.18500567
98MAPK30.18401660
99IRAK40.17776526
100MAPK130.17360844

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.45580364
2Graft-versus-host disease_Homo sapiens_hsa053323.61346317
3Proteasome_Homo sapiens_hsa030503.55377389
4Antigen processing and presentation_Homo sapiens_hsa046123.32020117
5Autoimmune thyroid disease_Homo sapiens_hsa053203.28088503
6Allograft rejection_Homo sapiens_hsa053303.13798470
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.92918991
8Oxidative phosphorylation_Homo sapiens_hsa001902.76367827
9Hematopoietic cell lineage_Homo sapiens_hsa046402.72950303
10Type I diabetes mellitus_Homo sapiens_hsa049402.66678303
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.46401798
12T cell receptor signaling pathway_Homo sapiens_hsa046602.45283177
13Parkinsons disease_Homo sapiens_hsa050122.32043795
14Rheumatoid arthritis_Homo sapiens_hsa053232.11315737
15Intestinal immune network for IgA production_Homo sapiens_hsa046722.03311714
16Asthma_Homo sapiens_hsa053101.87881995
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.73779592
18Protein export_Homo sapiens_hsa030601.54951431
19Alzheimers disease_Homo sapiens_hsa050101.52387115
20Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.50117220
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.47928272
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.46414530
23Phototransduction_Homo sapiens_hsa047441.43341748
24RNA polymerase_Homo sapiens_hsa030201.42833171
25Ribosome_Homo sapiens_hsa030101.41652043
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.36341156
27Viral myocarditis_Homo sapiens_hsa054161.34291477
28Measles_Homo sapiens_hsa051621.31250470
29Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.30251090
30Cardiac muscle contraction_Homo sapiens_hsa042601.28377263
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.26020588
32Shigellosis_Homo sapiens_hsa051311.21215601
33Huntingtons disease_Homo sapiens_hsa050161.18492364
34Salmonella infection_Homo sapiens_hsa051321.16578222
35Malaria_Homo sapiens_hsa051441.05225719
36Caffeine metabolism_Homo sapiens_hsa002321.03832465
37Linoleic acid metabolism_Homo sapiens_hsa005911.03450468
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.01896427
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01052597
40Toll-like receptor signaling pathway_Homo sapiens_hsa046200.89787924
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88579991
42Leishmaniasis_Homo sapiens_hsa051400.85951975
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85084839
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84451369
45Staphylococcus aureus infection_Homo sapiens_hsa051500.82382350
46Systemic lupus erythematosus_Homo sapiens_hsa053220.80799925
47Nitrogen metabolism_Homo sapiens_hsa009100.77282120
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72651733
49Herpes simplex infection_Homo sapiens_hsa051680.71123634
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.70294714
51Peroxisome_Homo sapiens_hsa041460.66132634
52Regulation of autophagy_Homo sapiens_hsa041400.63556768
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63079891
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57662200
55Chemokine signaling pathway_Homo sapiens_hsa040620.54804937
56Collecting duct acid secretion_Homo sapiens_hsa049660.53092567
57Legionellosis_Homo sapiens_hsa051340.52487896
58Homologous recombination_Homo sapiens_hsa034400.51779165
59Tryptophan metabolism_Homo sapiens_hsa003800.49949944
60Pertussis_Homo sapiens_hsa051330.48418636
61Butanoate metabolism_Homo sapiens_hsa006500.48039459
62Chemical carcinogenesis_Homo sapiens_hsa052040.47740576
63Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.47136550
64Purine metabolism_Homo sapiens_hsa002300.46583559
65Olfactory transduction_Homo sapiens_hsa047400.46341146
66Sulfur metabolism_Homo sapiens_hsa009200.46082925
67RNA degradation_Homo sapiens_hsa030180.45370230
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45339340
69Osteoclast differentiation_Homo sapiens_hsa043800.43457932
70Fanconi anemia pathway_Homo sapiens_hsa034600.41943486
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39702044
72Propanoate metabolism_Homo sapiens_hsa006400.39692360
73Retinol metabolism_Homo sapiens_hsa008300.36843151
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.35975684
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.35368832
76TNF signaling pathway_Homo sapiens_hsa046680.34605440
77Epstein-Barr virus infection_Homo sapiens_hsa051690.31881927
78Pyrimidine metabolism_Homo sapiens_hsa002400.31784108
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29997694
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.29985079
81Arachidonic acid metabolism_Homo sapiens_hsa005900.28781977
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.26604371
83Morphine addiction_Homo sapiens_hsa050320.23641858
84Ether lipid metabolism_Homo sapiens_hsa005650.23317563
85Apoptosis_Homo sapiens_hsa042100.23306452
86HTLV-I infection_Homo sapiens_hsa051660.22888380
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.22797950
88Nicotine addiction_Homo sapiens_hsa050330.21509600
89Tuberculosis_Homo sapiens_hsa051520.21362195
90Influenza A_Homo sapiens_hsa051640.20893909
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.19530513
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.17812553
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.16800508
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16667103
95Taste transduction_Homo sapiens_hsa047420.15988500
96Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.14329794
97Phagosome_Homo sapiens_hsa041450.13616800
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.13349967
99Basal transcription factors_Homo sapiens_hsa030220.13301585
100Metabolic pathways_Homo sapiens_hsa011000.12500102

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