

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | cell wall macromolecule catabolic process (GO:0016998) | 8.54629670 |
| 2 | cell wall macromolecule metabolic process (GO:0044036) | 7.17604542 |
| 3 | DNA deamination (GO:0045006) | 6.71337011 |
| 4 | regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091 | 6.14995843 |
| 5 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 5.76635712 |
| 6 | protein maturation by protein folding (GO:0022417) | 5.58493382 |
| 7 | cytidine metabolic process (GO:0046087) | 5.56021547 |
| 8 | cytidine catabolic process (GO:0006216) | 5.56021547 |
| 9 | cytidine deamination (GO:0009972) | 5.56021547 |
| 10 | establishment of viral latency (GO:0019043) | 5.24574221 |
| 11 | positive regulation of actin filament depolymerization (GO:0030836) | 4.98219042 |
| 12 | proteasome assembly (GO:0043248) | 4.73566227 |
| 13 | extracellular fibril organization (GO:0043206) | 4.35769427 |
| 14 | GDP-mannose metabolic process (GO:0019673) | 4.34007707 |
| 15 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 4.26454881 |
| 16 | regulation of cilium movement (GO:0003352) | 4.19562328 |
| 17 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 4.15523107 |
| 18 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.13630419 |
| 19 | protein deneddylation (GO:0000338) | 4.11963855 |
| 20 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.03166245 |
| 21 | detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580) | 4.02247155 |
| 22 | glomerular visceral epithelial cell development (GO:0072015) | 3.96953207 |
| 23 | pyrimidine nucleoside catabolic process (GO:0046135) | 3.89855817 |
| 24 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.84602185 |
| 25 | detection of chemical stimulus involved in sensory perception of taste (GO:0050912) | 3.81554372 |
| 26 | myelin assembly (GO:0032288) | 3.80076603 |
| 27 | response to interferon-beta (GO:0035456) | 3.80028044 |
| 28 | nuclear envelope reassembly (GO:0031468) | 3.79671270 |
| 29 | mitotic nuclear envelope reassembly (GO:0007084) | 3.79671270 |
| 30 | fibril organization (GO:0097435) | 3.78909562 |
| 31 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.75246001 |
| 32 | mannosylation (GO:0097502) | 3.73896828 |
| 33 | fibroblast migration (GO:0010761) | 3.69192963 |
| 34 | establishment of integrated proviral latency (GO:0075713) | 3.68743139 |
| 35 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.64035572 |
| 36 | ATP synthesis coupled proton transport (GO:0015986) | 3.64035572 |
| 37 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.62524528 |
| 38 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.62524528 |
| 39 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.61369496 |
| 40 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.61369496 |
| 41 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.61369496 |
| 42 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.61361923 |
| 43 | ribosome assembly (GO:0042255) | 3.58926098 |
| 44 | actin filament depolymerization (GO:0030042) | 3.53666477 |
| 45 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.53103386 |
| 46 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.53103386 |
| 47 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.45178908 |
| 48 | glomerular epithelial cell development (GO:0072310) | 3.45172685 |
| 49 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.45157427 |
| 50 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.44737469 |
| 51 | response to gravity (GO:0009629) | 3.44461331 |
| 52 | negative regulation of calcium ion transport into cytosol (GO:0010523) | 3.43976373 |
| 53 | positive regulation of macrophage activation (GO:0043032) | 3.40755739 |
| 54 | branched-chain amino acid catabolic process (GO:0009083) | 3.36776743 |
| 55 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.33116849 |
| 56 | negative regulation of ligase activity (GO:0051352) | 3.33116849 |
| 57 | positive regulation of mitochondrial calcium ion concentration (GO:0051561) | 3.30375042 |
| 58 | chaperone mediated protein folding requiring cofactor (GO:0051085) | 3.30181171 |
| 59 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.27037159 |
| 60 | sequestering of actin monomers (GO:0042989) | 3.25437397 |
| 61 | organelle membrane fusion (GO:0090174) | 3.25376681 |
| 62 | cullin deneddylation (GO:0010388) | 3.23224695 |
| 63 | retina homeostasis (GO:0001895) | 3.20099085 |
| 64 | chaperone-mediated protein transport (GO:0072321) | 3.18640470 |
| 65 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.16753399 |
| 66 | protein peptidyl-prolyl isomerization (GO:0000413) | 3.16525517 |
| 67 | positive regulation of monocyte chemotaxis (GO:0090026) | 3.08062810 |
| 68 | xenobiotic catabolic process (GO:0042178) | 3.05200250 |
| 69 | protein complex biogenesis (GO:0070271) | 3.03457047 |
| 70 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.00289272 |
| 71 | negative regulation of viral genome replication (GO:0045071) | 3.00030950 |
| 72 | negative regulation of T cell apoptotic process (GO:0070233) | 2.97972517 |
| 73 | negative regulation of JAK-STAT cascade (GO:0046426) | 2.96245230 |
| 74 | regulation of metalloenzyme activity (GO:0048552) | 2.96156944 |
| 75 | dolichol-linked oligosaccharide biosynthetic process (GO:0006488) | 2.94532230 |
| 76 | antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) | 2.93604919 |
| 77 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 2.90481789 |
| 78 | GMP metabolic process (GO:0046037) | 2.90355738 |
| 79 | type B pancreatic cell proliferation (GO:0044342) | 2.87421835 |
| 80 | positive regulation of interleukin-8 secretion (GO:2000484) | 2.85406025 |
| 81 | Arp2/3 complex-mediated actin nucleation (GO:0034314) | 2.81625086 |
| 82 | rRNA modification (GO:0000154) | 2.81073803 |
| 83 | cytolysis (GO:0019835) | 2.80394023 |
| 84 | auditory receptor cell differentiation (GO:0042491) | 2.80278037 |
| 85 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 2.80122838 |
| 86 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 2.80122838 |
| 87 | NADH dehydrogenase complex assembly (GO:0010257) | 2.80122838 |
| 88 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 2.80051566 |
| 89 | regulation of cellular amine metabolic process (GO:0033238) | 2.78889425 |
| 90 | C-terminal protein lipidation (GO:0006501) | 2.75845558 |
| 91 | respiratory electron transport chain (GO:0022904) | 2.75845157 |
| 92 | positive regulation of cell cycle arrest (GO:0071158) | 2.75128669 |
| 93 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.74845409 |
| 94 | metallo-sulfur cluster assembly (GO:0031163) | 2.74030566 |
| 95 | iron-sulfur cluster assembly (GO:0016226) | 2.74030566 |
| 96 | electron transport chain (GO:0022900) | 2.72767430 |
| 97 | negative regulation of epidermal growth factor-activated receptor activity (GO:0007175) | 2.70594255 |
| 98 | protein heterotetramerization (GO:0051290) | 2.67984957 |
| 99 | negative regulation of lymphocyte apoptotic process (GO:0070229) | 2.66284263 |
| 100 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 2.63039907 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 5.21012785 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.74739657 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.68640150 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.63737572 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.54431490 |
| 6 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 3.20316510 |
| 7 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.02594645 |
| 8 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.00436059 |
| 9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.99321785 |
| 10 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.91873621 |
| 11 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.82940157 |
| 12 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.59576575 |
| 13 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.53346865 |
| 14 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.49587680 |
| 15 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.46555533 |
| 16 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.36791370 |
| 17 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 2.36081141 |
| 18 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 2.26721248 |
| 19 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 2.24568377 |
| 20 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 2.14824890 |
| 21 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.07737368 |
| 22 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.04152132 |
| 23 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.02897277 |
| 24 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 2.01941294 |
| 25 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 2.00474651 |
| 26 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.98390098 |
| 27 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.90139214 |
| 28 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.84732082 |
| 29 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.81514402 |
| 30 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.79395440 |
| 31 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.78439311 |
| 32 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.78306441 |
| 33 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.74311817 |
| 34 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.69906334 |
| 35 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 1.69576885 |
| 36 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.69056452 |
| 37 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 1.68491538 |
| 38 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.65659336 |
| 39 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.62549715 |
| 40 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.61891191 |
| 41 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.61636923 |
| 42 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.57092102 |
| 43 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.55704319 |
| 44 | VDR_22108803_ChIP-Seq_LS180_Human | 1.55126053 |
| 45 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.54764020 |
| 46 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.54442137 |
| 47 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.51983840 |
| 48 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.50420468 |
| 49 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.48195544 |
| 50 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.45480260 |
| 51 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.43815526 |
| 52 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.43701654 |
| 53 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 1.42697505 |
| 54 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.42460755 |
| 55 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.41370283 |
| 56 | STAT4_19710469_ChIP-ChIP_TH1__Mouse | 1.40527644 |
| 57 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.39199170 |
| 58 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.36507094 |
| 59 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 1.30920937 |
| 60 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.27400940 |
| 61 | BCL6_27268052_Chip-Seq_Bcells_Human | 1.24318253 |
| 62 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.24109356 |
| 63 | CSB_26484114_Chip-Seq_FIBROBLAST_Human | 1.18474207 |
| 64 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 1.17957309 |
| 65 | RBPJ_21746931_ChIP-Seq_IB4-LCL_Human | 1.16470240 |
| 66 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.16111420 |
| 67 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.15587703 |
| 68 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 1.15093609 |
| 69 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.14520435 |
| 70 | MEIS1_20887958_ChIP-Seq_HPC-7_Mouse | 1.13455535 |
| 71 | E2F7_22180533_ChIP-Seq_HELA_Human | 1.13311039 |
| 72 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.08744986 |
| 73 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.07797846 |
| 74 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.06878654 |
| 75 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.06757118 |
| 76 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.06056462 |
| 77 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.02024573 |
| 78 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.01705348 |
| 79 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.99146702 |
| 80 | BCOR_27268052_Chip-Seq_Bcells_Human | 0.98985947 |
| 81 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 0.98856264 |
| 82 | ERG_20517297_ChIP-Seq_VCAP_Human | 0.98667025 |
| 83 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 0.98059228 |
| 84 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 0.96459447 |
| 85 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.95404285 |
| 86 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.94439505 |
| 87 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 0.93104513 |
| 88 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 0.91410924 |
| 89 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 0.90332910 |
| 90 | SPI1_20517297_ChIP-Seq_HL60_Human | 0.89987153 |
| 91 | P300_27268052_Chip-Seq_Bcells_Human | 0.89363801 |
| 92 | CTCF_20526341_ChIP-Seq_ESCs_Human | 0.88044541 |
| 93 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.88001252 |
| 94 | SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse | 0.87877014 |
| 95 | AR_20517297_ChIP-Seq_VCAP_Human | 0.87088283 |
| 96 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.86545709 |
| 97 | TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse | 0.86219382 |
| 98 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 0.85527343 |
| 99 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.85234687 |
| 100 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 0.85086050 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0010030_abnormal_orbit_morphology | 4.07894907 |
| 2 | MP0005360_urolithiasis | 3.30781740 |
| 3 | MP0008260_abnormal_autophagy | 3.27213531 |
| 4 | MP0005257_abnormal_intraocular_pressure | 3.06649009 |
| 5 | MP0008789_abnormal_olfactory_epithelium | 2.75958173 |
| 6 | MP0001542_abnormal_bone_strength | 2.61892679 |
| 7 | MP0010368_abnormal_lymphatic_system | 2.52761903 |
| 8 | MP0008875_abnormal_xenobiotic_pharmacok | 2.51041471 |
| 9 | MP0003191_abnormal_cellular_cholesterol | 2.45591498 |
| 10 | MP0003806_abnormal_nucleotide_metabolis | 2.39329066 |
| 11 | MP0002166_altered_tumor_susceptibility | 2.36304218 |
| 12 | MP0009333_abnormal_splenocyte_physiolog | 2.33674510 |
| 13 | MP0005671_abnormal_response_to | 2.21315127 |
| 14 | MP0002138_abnormal_hepatobiliary_system | 2.19022613 |
| 15 | MP0002006_tumorigenesis | 2.15222008 |
| 16 | MP0003123_paternal_imprinting | 2.00380837 |
| 17 | MP0004147_increased_porphyrin_level | 1.98490157 |
| 18 | MP0004272_abnormal_basement_membrane | 1.89808686 |
| 19 | MP0008775_abnormal_heart_ventricle | 1.89753407 |
| 20 | MP0009785_altered_susceptibility_to | 1.77740667 |
| 21 | MP0002876_abnormal_thyroid_physiology | 1.76664159 |
| 22 | MP0005058_abnormal_lysosome_morphology | 1.72995271 |
| 23 | MP0003950_abnormal_plasma_membrane | 1.71093955 |
| 24 | MP0009697_abnormal_copulation | 1.54989365 |
| 25 | MP0000750_abnormal_muscle_regeneration | 1.52922039 |
| 26 | MP0005165_increased_susceptibility_to | 1.51195006 |
| 27 | MP0009764_decreased_sensitivity_to | 1.50284797 |
| 28 | MP0001984_abnormal_olfaction | 1.46994541 |
| 29 | MP0006035_abnormal_mitochondrial_morpho | 1.44307016 |
| 30 | MP0003075_altered_response_to | 1.42099417 |
| 31 | MP0005332_abnormal_amino_acid | 1.35534109 |
| 32 | MP0004510_myositis | 1.34837615 |
| 33 | MP0005464_abnormal_platelet_physiology | 1.34062033 |
| 34 | MP0000858_altered_metastatic_potential | 1.31792857 |
| 35 | MP0006036_abnormal_mitochondrial_physio | 1.30519507 |
| 36 | MP0005365_abnormal_bile_salt | 1.30496664 |
| 37 | MP0003436_decreased_susceptibility_to | 1.30158442 |
| 38 | MP0006082_CNS_inflammation | 1.28091710 |
| 39 | MP0005551_abnormal_eye_electrophysiolog | 1.27631088 |
| 40 | MP0003638_abnormal_response/metabolism_ | 1.27414518 |
| 41 | MP0001905_abnormal_dopamine_level | 1.26804359 |
| 42 | MP0005394_taste/olfaction_phenotype | 1.24884475 |
| 43 | MP0005499_abnormal_olfactory_system | 1.24884475 |
| 44 | MP0003011_delayed_dark_adaptation | 1.21835097 |
| 45 | MP0003195_calcinosis | 1.21517358 |
| 46 | MP0003786_premature_aging | 1.20034640 |
| 47 | MP0005085_abnormal_gallbladder_physiolo | 1.18730487 |
| 48 | MP0002148_abnormal_hypersensitivity_rea | 1.18681958 |
| 49 | MP0002332_abnormal_exercise_endurance | 1.18455925 |
| 50 | MP0001485_abnormal_pinna_reflex | 1.17805200 |
| 51 | MP0003718_maternal_effect | 1.13707935 |
| 52 | MP0000749_muscle_degeneration | 1.13459906 |
| 53 | MP0002277_abnormal_respiratory_mucosa | 1.13071214 |
| 54 | MP0000751_myopathy | 1.10800547 |
| 55 | MP0002282_abnormal_trachea_morphology | 1.08983760 |
| 56 | MP0009780_abnormal_chondrocyte_physiolo | 1.05991153 |
| 57 | MP0000358_abnormal_cell_content/ | 1.05572595 |
| 58 | MP0005330_cardiomyopathy | 1.05200448 |
| 59 | MP0005319_abnormal_enzyme/_coenzyme | 1.04429327 |
| 60 | MP0003448_altered_tumor_morphology | 1.03256093 |
| 61 | MP0001879_abnormal_lymphatic_vessel | 1.02526368 |
| 62 | MP0005166_decreased_susceptibility_to | 1.02111961 |
| 63 | MP0001835_abnormal_antigen_presentation | 1.00261660 |
| 64 | MP0008872_abnormal_physiological_respon | 0.99147281 |
| 65 | MP0005395_other_phenotype | 0.99117832 |
| 66 | MP0005410_abnormal_fertilization | 0.97537768 |
| 67 | MP0002972_abnormal_cardiac_muscle | 0.97334820 |
| 68 | MP0008469_abnormal_protein_level | 0.96848609 |
| 69 | MP0000343_altered_response_to | 0.92498538 |
| 70 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.92287971 |
| 71 | MP0005000_abnormal_immune_tolerance | 0.91697083 |
| 72 | MP0003186_abnormal_redox_activity | 0.91047994 |
| 73 | MP0003763_abnormal_thymus_physiology | 0.90549250 |
| 74 | MP0001533_abnormal_skeleton_physiology | 0.90084620 |
| 75 | MP0006072_abnormal_retinal_apoptosis | 0.89849477 |
| 76 | MP0003567_abnormal_fetal_cardiomyocyte | 0.85426735 |
| 77 | MP0001727_abnormal_embryo_implantation | 0.85268012 |
| 78 | MP0009763_increased_sensitivity_to | 0.85200353 |
| 79 | MP0004742_abnormal_vestibular_system | 0.85025136 |
| 80 | MP0002723_abnormal_immune_serum | 0.84440596 |
| 81 | MP0008873_increased_physiological_sensi | 0.82110357 |
| 82 | MP0002420_abnormal_adaptive_immunity | 0.81724058 |
| 83 | MP0002019_abnormal_tumor_incidence | 0.81384494 |
| 84 | MP0003693_abnormal_embryo_hatching | 0.81137733 |
| 85 | MP0005451_abnormal_body_composition | 0.78587787 |
| 86 | MP0001819_abnormal_immune_cell | 0.77904716 |
| 87 | MP0001529_abnormal_vocalization | 0.77070417 |
| 88 | MP0002168_other_aberrant_phenotype | 0.75911164 |
| 89 | MP0010234_abnormal_vibrissa_follicle | 0.75875312 |
| 90 | MP0005025_abnormal_response_to | 0.75837195 |
| 91 | MP0001845_abnormal_inflammatory_respons | 0.74918969 |
| 92 | MP0005636_abnormal_mineral_homeostasis | 0.74275479 |
| 93 | MP0000703_abnormal_thymus_morphology | 0.73438666 |
| 94 | MP0000639_abnormal_adrenal_gland | 0.73247794 |
| 95 | MP0004145_abnormal_muscle_electrophysio | 0.73097669 |
| 96 | MP0001756_abnormal_urination | 0.72792964 |
| 97 | MP0002106_abnormal_muscle_physiology | 0.72624570 |
| 98 | MP0002722_abnormal_immune_system | 0.71782961 |
| 99 | MP0002736_abnormal_nociception_after | 0.70665037 |
| 100 | MP0000689_abnormal_spleen_morphology | 0.68100891 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Reduced subcutaneous adipose tissue (HP:0003758) | 4.44394115 |
| 2 | Hepatocellular necrosis (HP:0001404) | 4.38721301 |
| 3 | Cholecystitis (HP:0001082) | 4.38573660 |
| 4 | Abnormal gallbladder physiology (HP:0012438) | 4.38573660 |
| 5 | Reduced antithrombin III activity (HP:0001976) | 4.12505447 |
| 6 | Exercise-induced muscle cramps (HP:0003710) | 4.10156547 |
| 7 | Hypokinesia (HP:0002375) | 4.03026172 |
| 8 | Mitochondrial inheritance (HP:0001427) | 3.97459480 |
| 9 | Glucose intolerance (HP:0000833) | 3.97201592 |
| 10 | Type I transferrin isoform profile (HP:0003642) | 3.85643904 |
| 11 | Aplastic anemia (HP:0001915) | 3.75808817 |
| 12 | Elevated erythrocyte sedimentation rate (HP:0003565) | 3.66429377 |
| 13 | Hepatic necrosis (HP:0002605) | 3.65940849 |
| 14 | Adrenal hypoplasia (HP:0000835) | 3.41989945 |
| 15 | Short tibia (HP:0005736) | 3.38670048 |
| 16 | Acute necrotizing encephalopathy (HP:0006965) | 3.34964893 |
| 17 | Increased CSF lactate (HP:0002490) | 3.32319115 |
| 18 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.16260622 |
| 19 | Renal Fanconi syndrome (HP:0001994) | 3.13048021 |
| 20 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.11570056 |
| 21 | Cerebral edema (HP:0002181) | 3.09850121 |
| 22 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 3.09141573 |
| 23 | Abnormal protein glycosylation (HP:0012346) | 3.03709956 |
| 24 | Abnormal glycosylation (HP:0012345) | 3.03709956 |
| 25 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 3.03709956 |
| 26 | Abnormal protein N-linked glycosylation (HP:0012347) | 3.03709956 |
| 27 | Increased serum lactate (HP:0002151) | 2.95343019 |
| 28 | Nemaline bodies (HP:0003798) | 2.90027997 |
| 29 | Decreased subcutaneous fat (HP:0001002) | 2.85133731 |
| 30 | Increased serum pyruvate (HP:0003542) | 2.84608541 |
| 31 | Acute encephalopathy (HP:0006846) | 2.79615887 |
| 32 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.77532121 |
| 33 | Exercise intolerance (HP:0003546) | 2.77231513 |
| 34 | Increased hepatocellular lipid droplets (HP:0006565) | 2.76321618 |
| 35 | Delayed CNS myelination (HP:0002188) | 2.72944828 |
| 36 | Lactic acidosis (HP:0003128) | 2.71600109 |
| 37 | Tetraplegia (HP:0002445) | 2.71510751 |
| 38 | Progressive macrocephaly (HP:0004481) | 2.64428862 |
| 39 | Retinal dysplasia (HP:0007973) | 2.64014101 |
| 40 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.56651753 |
| 41 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.56651753 |
| 42 | Amyloidosis (HP:0011034) | 2.39111503 |
| 43 | Abnormal glucose tolerance (HP:0001952) | 2.38595272 |
| 44 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 2.36471114 |
| 45 | EMG: myopathic abnormalities (HP:0003458) | 2.32080452 |
| 46 | Synostosis involving the elbow (HP:0003938) | 2.31249996 |
| 47 | Humeroradial synostosis (HP:0003041) | 2.31249996 |
| 48 | Progressive muscle weakness (HP:0003323) | 2.31085731 |
| 49 | Lipid accumulation in hepatocytes (HP:0006561) | 2.30815099 |
| 50 | Respiratory failure (HP:0002878) | 2.26428028 |
| 51 | Abnormality of glycolysis (HP:0004366) | 2.25380101 |
| 52 | Increased intramyocellular lipid droplets (HP:0012240) | 2.24219533 |
| 53 | Exertional dyspnea (HP:0002875) | 2.23105888 |
| 54 | Microglossia (HP:0000171) | 2.22361241 |
| 55 | CNS demyelination (HP:0007305) | 2.21882365 |
| 56 | Delayed gross motor development (HP:0002194) | 2.21674421 |
| 57 | Opisthotonus (HP:0002179) | 2.19780341 |
| 58 | Rough bone trabeculation (HP:0100670) | 2.19587921 |
| 59 | Generalized amyotrophy (HP:0003700) | 2.19004527 |
| 60 | Muscle fiber inclusion bodies (HP:0100299) | 2.14309648 |
| 61 | Ketosis (HP:0001946) | 2.10260834 |
| 62 | Microretrognathia (HP:0000308) | 2.09759077 |
| 63 | Emotional lability (HP:0000712) | 2.07694025 |
| 64 | Median cleft lip (HP:0000161) | 2.06230254 |
| 65 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.05581796 |
| 66 | Abnormality of alanine metabolism (HP:0010916) | 2.05581796 |
| 67 | Hyperalaninemia (HP:0003348) | 2.05581796 |
| 68 | Pancytopenia (HP:0001876) | 2.04430055 |
| 69 | Abnormality of renal resorption (HP:0011038) | 2.01099006 |
| 70 | X-linked dominant inheritance (HP:0001423) | 1.99427039 |
| 71 | Large eyes (HP:0001090) | 1.97208032 |
| 72 | Large for gestational age (HP:0001520) | 1.95801146 |
| 73 | Hypoproteinemia (HP:0003075) | 1.93270056 |
| 74 | Increased IgM level (HP:0003496) | 1.91925752 |
| 75 | Molar tooth sign on MRI (HP:0002419) | 1.91860406 |
| 76 | Abnormality of midbrain morphology (HP:0002418) | 1.91860406 |
| 77 | Prolonged neonatal jaundice (HP:0006579) | 1.91600399 |
| 78 | Diminished movement (HP:0002374) | 1.89865382 |
| 79 | Hypoplastic pelvis (HP:0008839) | 1.88974177 |
| 80 | Optic disc pallor (HP:0000543) | 1.88739089 |
| 81 | Lethargy (HP:0001254) | 1.88383508 |
| 82 | Clubbing of toes (HP:0100760) | 1.87904290 |
| 83 | Muscle fiber atrophy (HP:0100295) | 1.85074269 |
| 84 | Type II lissencephaly (HP:0007260) | 1.82501512 |
| 85 | Increased muscle lipid content (HP:0009058) | 1.82148636 |
| 86 | Joint hemorrhage (HP:0005261) | 1.80858866 |
| 87 | Abnormality of the preputium (HP:0100587) | 1.80785166 |
| 88 | Pancreatitis (HP:0001733) | 1.80343220 |
| 89 | Abnormality of the ileum (HP:0001549) | 1.78517817 |
| 90 | Pustule (HP:0200039) | 1.77667952 |
| 91 | Entropion (HP:0000621) | 1.75820151 |
| 92 | Abnormal trabecular bone morphology (HP:0100671) | 1.75788872 |
| 93 | Erythema (HP:0010783) | 1.74389500 |
| 94 | IgG deficiency (HP:0004315) | 1.73619535 |
| 95 | Type 2 muscle fiber atrophy (HP:0003554) | 1.73037675 |
| 96 | Metabolic acidosis (HP:0001942) | 1.72509556 |
| 97 | Pancreatic cysts (HP:0001737) | 1.72486348 |
| 98 | Vascular calcification (HP:0004934) | 1.71974034 |
| 99 | Congenital, generalized hypertrichosis (HP:0004540) | 1.70964463 |
| 100 | Decreased electroretinogram (ERG) amplitude (HP:0000654) | 1.70917791 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 4.88236396 |
| 2 | BCKDK | 4.87145766 |
| 3 | TESK2 | 4.75374490 |
| 4 | LIMK1 | 4.65367756 |
| 5 | ARAF | 4.59475575 |
| 6 | TESK1 | 4.02577574 |
| 7 | NME2 | 3.43597315 |
| 8 | KDR | 3.21134896 |
| 9 | MAP3K13 | 2.91533854 |
| 10 | EIF2AK3 | 2.19974375 |
| 11 | MOS | 1.90730917 |
| 12 | MAP3K9 | 1.86820060 |
| 13 | EPHA2 | 1.80677755 |
| 14 | MST4 | 1.74437994 |
| 15 | TIE1 | 1.71104224 |
| 16 | LMTK2 | 1.68806943 |
| 17 | DAPK1 | 1.64391097 |
| 18 | EPHA4 | 1.60752184 |
| 19 | MAPKAPK3 | 1.57611784 |
| 20 | BUB1 | 1.44406490 |
| 21 | VRK1 | 1.43847162 |
| 22 | PIM2 | 1.39458640 |
| 23 | NUAK1 | 1.37441753 |
| 24 | ZAK | 1.33487777 |
| 25 | SCYL2 | 1.32848488 |
| 26 | CSNK1G3 | 1.26658738 |
| 27 | PHKG2 | 1.19081924 |
| 28 | PHKG1 | 1.19081924 |
| 29 | GRK6 | 1.13229810 |
| 30 | CSNK1A1L | 1.06534449 |
| 31 | BRSK2 | 1.02773145 |
| 32 | BRAF | 1.00835396 |
| 33 | ILK | 0.97348367 |
| 34 | TAOK2 | 0.95080508 |
| 35 | BRSK1 | 0.95056829 |
| 36 | RIPK1 | 0.93873931 |
| 37 | CSNK1G2 | 0.87166933 |
| 38 | RAF1 | 0.85129130 |
| 39 | CSNK1G1 | 0.85036985 |
| 40 | MUSK | 0.84041971 |
| 41 | MYLK | 0.82541232 |
| 42 | MAP3K12 | 0.82482921 |
| 43 | TAF1 | 0.79021018 |
| 44 | TLK1 | 0.77701505 |
| 45 | STK16 | 0.76998561 |
| 46 | MAP4K2 | 0.76604781 |
| 47 | ABL2 | 0.73573548 |
| 48 | EIF2AK2 | 0.68623056 |
| 49 | NEK1 | 0.67906069 |
| 50 | PTK2B | 0.67676029 |
| 51 | GRK5 | 0.65345912 |
| 52 | PAK1 | 0.64385060 |
| 53 | MAP2K7 | 0.64373046 |
| 54 | SRPK1 | 0.61002652 |
| 55 | PAK4 | 0.59844411 |
| 56 | STK10 | 0.59578766 |
| 57 | MST1R | 0.57475528 |
| 58 | GRK1 | 0.57351835 |
| 59 | DAPK3 | 0.56803892 |
| 60 | CDK8 | 0.55653915 |
| 61 | TBK1 | 0.53159648 |
| 62 | WEE1 | 0.49735052 |
| 63 | PLK2 | 0.49554934 |
| 64 | MAP3K1 | 0.49112572 |
| 65 | AURKA | 0.47336746 |
| 66 | GRK7 | 0.46376157 |
| 67 | PRKCQ | 0.46101353 |
| 68 | PBK | 0.43488389 |
| 69 | ADRBK2 | 0.41879450 |
| 70 | MAP3K3 | 0.39600464 |
| 71 | INSRR | 0.38947557 |
| 72 | CCNB1 | 0.38351899 |
| 73 | IKBKB | 0.35324691 |
| 74 | HIPK2 | 0.34722510 |
| 75 | TEC | 0.32094632 |
| 76 | PRKCE | 0.30198835 |
| 77 | CAMK2G | 0.29948175 |
| 78 | MAPKAPK2 | 0.29866523 |
| 79 | CSNK2A2 | 0.28561099 |
| 80 | CDK14 | 0.27756896 |
| 81 | SMG1 | 0.26985589 |
| 82 | PRKCI | 0.26596713 |
| 83 | CDK7 | 0.26309375 |
| 84 | EPHB2 | 0.26112785 |
| 85 | RPS6KA5 | 0.25777708 |
| 86 | CSNK1A1 | 0.25057250 |
| 87 | AURKB | 0.24870393 |
| 88 | PDK2 | 0.22425759 |
| 89 | PLK3 | 0.21153944 |
| 90 | KSR2 | 0.20856896 |
| 91 | TGFBR2 | 0.20672057 |
| 92 | CDK15 | 0.20648345 |
| 93 | LRRK2 | 0.20401771 |
| 94 | PLK1 | 0.20286232 |
| 95 | CDK11A | 0.20030966 |
| 96 | ADRBK1 | 0.19959223 |
| 97 | TAOK3 | 0.19355277 |
| 98 | CDK18 | 0.17999142 |
| 99 | ERBB4 | 0.17621905 |
| 100 | WNK3 | 0.16334445 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.55380002 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.34316557 |
| 3 | Parkinsons disease_Homo sapiens_hsa05012 | 2.97506653 |
| 4 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 2.79964284 |
| 5 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.57540681 |
| 6 | RNA polymerase_Homo sapiens_hsa03020 | 2.57330441 |
| 7 | Huntingtons disease_Homo sapiens_hsa05016 | 2.37726865 |
| 8 | Alzheimers disease_Homo sapiens_hsa05010 | 2.13110336 |
| 9 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.12185670 |
| 10 | Sulfur metabolism_Homo sapiens_hsa00920 | 2.09099319 |
| 11 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.91390408 |
| 12 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.90084277 |
| 13 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.82900319 |
| 14 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.78310423 |
| 15 | DNA replication_Homo sapiens_hsa03030 | 1.78024459 |
| 16 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.77243666 |
| 17 | Ribosome_Homo sapiens_hsa03010 | 1.72370358 |
| 18 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.69873355 |
| 19 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.69637499 |
| 20 | Homologous recombination_Homo sapiens_hsa03440 | 1.65197776 |
| 21 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.64787361 |
| 22 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.63179377 |
| 23 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.59671710 |
| 24 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.59481593 |
| 25 | Sulfur relay system_Homo sapiens_hsa04122 | 1.56856552 |
| 26 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.56553255 |
| 27 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.43691308 |
| 28 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.38759272 |
| 29 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.35100071 |
| 30 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.34112200 |
| 31 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.33399704 |
| 32 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.33164657 |
| 33 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.32412287 |
| 34 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.28449250 |
| 35 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.27572815 |
| 36 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.20915855 |
| 37 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.20316383 |
| 38 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.19940079 |
| 39 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.16447957 |
| 40 | Protein export_Homo sapiens_hsa03060 | 1.16076907 |
| 41 | Base excision repair_Homo sapiens_hsa03410 | 1.15999854 |
| 42 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.15325486 |
| 43 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 1.14020629 |
| 44 | Mismatch repair_Homo sapiens_hsa03430 | 1.12428682 |
| 45 | Purine metabolism_Homo sapiens_hsa00230 | 1.10976291 |
| 46 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.04996842 |
| 47 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.03813915 |
| 48 | Peroxisome_Homo sapiens_hsa04146 | 1.01810245 |
| 49 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.01518840 |
| 50 | Retinol metabolism_Homo sapiens_hsa00830 | 0.99129508 |
| 51 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.98214908 |
| 52 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.98143813 |
| 53 | Shigellosis_Homo sapiens_hsa05131 | 0.97413396 |
| 54 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.96581949 |
| 55 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.95968112 |
| 56 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.92017195 |
| 57 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.89857769 |
| 58 | Carbon metabolism_Homo sapiens_hsa01200 | 0.89356427 |
| 59 | Basal transcription factors_Homo sapiens_hsa03022 | 0.89321574 |
| 60 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.85800356 |
| 61 | Salivary secretion_Homo sapiens_hsa04970 | 0.84573288 |
| 62 | Other glycan degradation_Homo sapiens_hsa00511 | 0.84058658 |
| 63 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.83259792 |
| 64 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.78785501 |
| 65 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.77323092 |
| 66 | Metabolic pathways_Homo sapiens_hsa01100 | 0.75271639 |
| 67 | Lysosome_Homo sapiens_hsa04142 | 0.73831281 |
| 68 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.71462717 |
| 69 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.68381346 |
| 70 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.65873146 |
| 71 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.61599976 |
| 72 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.53200634 |
| 73 | Allograft rejection_Homo sapiens_hsa05330 | 0.53133128 |
| 74 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.52899522 |
| 75 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.52072726 |
| 76 | Galactose metabolism_Homo sapiens_hsa00052 | 0.50163461 |
| 77 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.49990444 |
| 78 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.49886461 |
| 79 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.48026975 |
| 80 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.47609609 |
| 81 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.42013361 |
| 82 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.41475351 |
| 83 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.40732804 |
| 84 | Spliceosome_Homo sapiens_hsa03040 | 0.40568225 |
| 85 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.39934413 |
| 86 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.36875041 |
| 87 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 0.36531940 |
| 88 | Viral myocarditis_Homo sapiens_hsa05416 | 0.33993839 |
| 89 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.30988727 |
| 90 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.29373324 |
| 91 | RNA degradation_Homo sapiens_hsa03018 | 0.29033155 |
| 92 | RNA transport_Homo sapiens_hsa03013 | 0.28279224 |
| 93 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.28272220 |
| 94 | Phagosome_Homo sapiens_hsa04145 | 0.28258978 |
| 95 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 0.28053366 |
| 96 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.26123121 |
| 97 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.24201855 |
| 98 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.23874966 |
| 99 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.23398748 |
| 100 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.19160546 |

