ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cellular response to ethanol (GO:0071361)	5.19307821
2	protein K11-linked deubiquitination (GO:0035871)	5.08058563
3	monoubiquitinated protein deubiquitination (GO:0035520)	4.91307520
4	establishment of protein localization to Golgi (GO:0072600)	4.39331754
5	regulation of hippo signaling (GO:0035330)	4.35584895
6	interkinetic nuclear migration (GO:0022027)	4.32329368
7	regulation of establishment of cell polarity (GO:2000114)	4.21019112
8	positive regulation of developmental pigmentation (GO:0048087)	4.20452415
9	protein K48-linked deubiquitination (GO:0071108)	4.06358125
10	cytoplasmic mRNA processing body assembly (GO:0033962)	4.05614089
11	regulation of pigment cell differentiation (GO:0050932)	4.05505731
12	neural tube formation (GO:0001841)	4.00699291
13	lipid translocation (GO:0034204)	4.00564466
14	phospholipid translocation (GO:0045332)	4.00564466
15	indole-containing compound catabolic process (GO:0042436)	3.82164251
16	indolalkylamine catabolic process (GO:0046218)	3.82164251
17	tryptophan catabolic process (GO:0006569)	3.82164251
18	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.81222575
19	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.81222575
20	regulation of translation, ncRNA-mediated (GO:0045974)	3.81222575
21	regulation of establishment or maintenance of cell polarity (GO:0032878)	3.58138085
22	protein prenylation (GO:0018342)	3.49734039
23	prenylation (GO:0097354)	3.49734039
24	pericardium development (GO:0060039)	3.47528256
25	snRNA transcription (GO:0009301)	3.47397996
26	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.47274972
27	indolalkylamine metabolic process (GO:0006586)	3.44081259
28	protein K63-linked deubiquitination (GO:0070536)	3.43541067
29	negative regulation of complement activation (GO:0045916)	3.40939371
30	righting reflex (GO:0060013)	3.40300752
31	tryptophan metabolic process (GO:0006568)	3.36392228
32	negative regulation of protein activation cascade (GO:2000258)	3.29496614
33	protein targeting to vacuole (GO:0006623)	3.29000283
34	protein targeting to lysosome (GO:0006622)	3.29000283
35	establishment of protein localization to vacuole (GO:0072666)	3.29000283
36	phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)	3.26123560
37	oxidative demethylation (GO:0070989)	3.20142080
38	retrograde transport, vesicle recycling within Golgi (GO:0000301)	3.19296005
39	histone mRNA catabolic process (GO:0071044)	3.15526546
40	cellular response to sterol (GO:0036315)	3.14737759
41	protein targeting to Golgi (GO:0000042)	3.13986356
42	histone H3-K4 trimethylation (GO:0080182)	3.13669609
43	interleukin-6-mediated signaling pathway (GO:0070102)	3.04455584
44	sulfation (GO:0051923)	3.03708553
45	cAMP catabolic process (GO:0006198)	3.03163247
46	reflex (GO:0060004)	2.98726006
47	photoreceptor cell maintenance (GO:0045494)	2.97530827
48	cilium or flagellum-dependent cell motility (GO:0001539)	2.96822564
49	fibroblast migration (GO:0010761)	2.90877929
50	rRNA catabolic process (GO:0016075)	2.89659644
51	nucleus localization (GO:0051647)	2.85989889
52	cyclic nucleotide catabolic process (GO:0009214)	2.85423622
53	microtubule anchoring (GO:0034453)	2.83054906
54	kynurenine metabolic process (GO:0070189)	2.82565208
55	drug catabolic process (GO:0042737)	2.80460064
56	thyroid hormone metabolic process (GO:0042403)	2.79925550
57	negative regulation of systemic arterial blood pressure (GO:0003085)	2.77354869
58	flavonoid metabolic process (GO:0009812)	2.73325146
59	hepatocyte apoptotic process (GO:0097284)	2.69405971
60	regulation of MHC class I biosynthetic process (GO:0045343)	2.66742671
61	UDP-N-acetylglucosamine metabolic process (GO:0006047)	2.61969577
62	histone H3-K9 methylation (GO:0051567)	2.61923603
63	negative regulation of sodium ion transport (GO:0010766)	2.61830880
64	protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)	2.61495802
65	response to sterol (GO:0036314)	2.56526608
66	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)	2.55707563
67	regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)	2.55707563
68	signal peptide processing (GO:0006465)	2.52485477
69	detection of light stimulus involved in visual perception (GO:0050908)	2.52457639
70	detection of light stimulus involved in sensory perception (GO:0050962)	2.52457639
71	peptidyl-lysine trimethylation (GO:0018023)	2.51074134
72	regulation of alkaline phosphatase activity (GO:0010692)	2.51012399
73	replicative senescence (GO:0090399)	2.50240181
74	amino-acid betaine transport (GO:0015838)	2.50063402
75	carnitine transport (GO:0015879)	2.50063402
76	regulation of protein polyubiquitination (GO:1902914)	2.49998442
77	adaptation of signaling pathway (GO:0023058)	2.48498534
78	peptidyl-lysine methylation (GO:0018022)	2.45921454
79	lymphangiogenesis (GO:0001946)	2.45500901
80	histone lysine methylation (GO:0034968)	2.45342905
81	sphingoid metabolic process (GO:0046519)	2.44127381
82	regulation of gene silencing by RNA (GO:0060966)	2.43578081
83	regulation of posttranscriptional gene silencing (GO:0060147)	2.43578081
84	regulation of gene silencing by miRNA (GO:0060964)	2.43578081
85	regulation of B cell receptor signaling pathway (GO:0050855)	2.43235640
86	Golgi to endosome transport (GO:0006895)	2.42410707
87	striated muscle atrophy (GO:0014891)	2.40999635
88	iron ion import (GO:0097286)	2.40674929
89	alkaloid metabolic process (GO:0009820)	2.39253594
90	carnitine transmembrane transport (GO:1902603)	2.38877275
91	histone H3-K9 modification (GO:0061647)	2.38407789
92	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.37576009
93	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.37576009
94	negative regulation of humoral immune response (GO:0002921)	2.36505093
95	positive regulation of mRNA catabolic process (GO:0061014)	2.36422523
96	interferon-gamma production (GO:0032609)	2.35837186
97	auditory receptor cell stereocilium organization (GO:0060088)	2.32912174
98	regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)	2.31380159
99	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO	2.31380159
100	activated T cell proliferation (GO:0050798)	2.30316217

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	3.58748040
2	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	3.13011292
3	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.83413425
4	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.78014555
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.62906214
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.40700398
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.36498171
8	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.36272775
9	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.34823760
10	TAF15_26573619_Chip-Seq_HEK293_Human	2.30816737
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.30373910
12	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.29007266
13	TP53_16413492_ChIP-PET_HCT116_Human	2.19544987
14	VDR_22108803_ChIP-Seq_LS180_Human	2.05961276
15	IGF1R_20145208_ChIP-Seq_DFB_Human	2.03311282
16	AR_21572438_ChIP-Seq_LNCaP_Human	1.97944125
17	ER_23166858_ChIP-Seq_MCF-7_Human	1.97372739
18	STAT3_23295773_ChIP-Seq_U87_Human	1.96542923
19	ZNF274_21170338_ChIP-Seq_K562_Hela	1.94719769
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.94657066
21	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.92976695
22	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.92148617
23	SMAD4_21799915_ChIP-Seq_A2780_Human	1.86198259
24	EWS_26573619_Chip-Seq_HEK293_Human	1.82949790
25	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.82557806
26	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.80724768
27	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.75523398
28	P300_19829295_ChIP-Seq_ESCs_Human	1.75173348
29	FUS_26573619_Chip-Seq_HEK293_Human	1.73704351
30	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.73207621
31	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.71142366
32	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.70565128
33	TCF4_23295773_ChIP-Seq_U87_Human	1.68440904
34	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.67933991
35	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.64113656
36	AHR_22903824_ChIP-Seq_MCF-7_Human	1.58250417
37	CBP_20019798_ChIP-Seq_JUKART_Human	1.57926491
38	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.57926491
39	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.57437351
40	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.54823314
41	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.53186944
42	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.51776927
43	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.51737810
44	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.50051717
45	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.47480104
46	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.44442050
47	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.40956656
48	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.40396670
49	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.39989204
50	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.39761941
51	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.39609024
52	AR_25329375_ChIP-Seq_VCAP_Human	1.39015371
53	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.38530164
54	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.38349529
55	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.37868409
56	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.37868409
57	BCAT_22108803_ChIP-Seq_LS180_Human	1.36120658
58	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.35384438
59	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.34172744
60	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.33619150
61	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.29870266
62	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.27695500
63	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.27556967
64	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.26713186
65	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.26499185
66	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.25963986
67	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.25387581
68	RXR_22108803_ChIP-Seq_LS180_Human	1.24736073
69	CJUN_26792858_Chip-Seq_BT549_Human	1.22464087
70	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.22162645
71	IRF1_19129219_ChIP-ChIP_H3396_Human	1.21257910
72	TCF4_22108803_ChIP-Seq_LS180_Human	1.20327996
73	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.20323777
74	CDX2_22108803_ChIP-Seq_LS180_Human	1.19706628
75	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.19566531
76	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.19403903
77	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.19403903
78	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.19075371
79	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.18085526
80	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.17791797
81	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.17601748
82	RUNX2_22187159_ChIP-Seq_PCA_Human	1.16589139
83	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.15931489
84	TP53_18474530_ChIP-ChIP_U2OS_Human	1.14890978
85	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.10925662
86	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.09849133
87	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.09142516
88	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.09082279
89	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.08696030
90	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.08219072
91	KDM2B_26808549_Chip-Seq_REH_Human	1.05271295
92	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.05053358
93	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.04594307
94	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.04549312
95	RUNX_20019798_ChIP-Seq_JUKART_Human	1.04544648
96	P53_22387025_ChIP-Seq_ESCs_Mouse	1.03035529
97	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.01409478
98	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.01104858
99	BRD4_25478319_ChIP-Seq_HGPS_Human	1.00042207
100	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99353997

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000569_abnormal_digit_pigmentation	6.26888489
2	MP0008057_abnormal_DNA_replication	6.06243804
3	MP0002138_abnormal_hepatobiliary_system	4.46123380
4	MP0003195_calcinosis	4.09084807
5	MP0003252_abnormal_bile_duct	3.42463862
6	MP0003045_fibrosis	2.54577690
7	MP0000383_abnormal_hair_follicle	2.37252407
8	MP0002009_preneoplasia	2.36815150
9	MP0004043_abnormal_pH_regulation	2.35579841
10	MP0002928_abnormal_bile_duct	2.32619204
11	MP0005171_absent_coat_pigmentation	2.24764252
12	MP0000427_abnormal_hair_cycle	2.22504250
13	MP0005174_abnormal_tail_pigmentation	2.21159726
14	MP0002168_other_aberrant_phenotype	2.15688170
15	MP0003950_abnormal_plasma_membrane	2.00174914
16	MP0002736_abnormal_nociception_after	1.82444979
17	MP0006054_spinal_hemorrhage	1.81902519
18	MP0008961_abnormal_basal_metabolism	1.79784638
19	MP0000371_diluted_coat_color	1.77383675
20	MP0010678_abnormal_skin_adnexa	1.74110049
21	MP0001968_abnormal_touch/_nociception	1.66031753
22	MP0010386_abnormal_urinary_bladder	1.61756707
23	MP0003890_abnormal_embryonic-extraembry	1.59372867
24	MP0004381_abnormal_hair_follicle	1.55026598
25	MP0003763_abnormal_thymus_physiology	1.53893747
26	MP0005310_abnormal_salivary_gland	1.52661959
27	MP0001501_abnormal_sleep_pattern	1.48918702
28	MP0005085_abnormal_gallbladder_physiolo	1.46326623
29	MP0000015_abnormal_ear_pigmentation	1.37417905
30	MP0005551_abnormal_eye_electrophysiolog	1.33099175
31	MP0003300_gastrointestinal_ulcer	1.32060999
32	MP0003646_muscle_fatigue	1.31960862
33	MP0001986_abnormal_taste_sensitivity	1.31861425
34	MP0004130_abnormal_muscle_cell	1.31558436
35	MP0005167_abnormal_blood-brain_barrier	1.25684673
36	MP0003136_yellow_coat_color	1.25059095
37	MP0004142_abnormal_muscle_tone	1.22886648
38	MP0009697_abnormal_copulation	1.20197220
39	MP0005266_abnormal_metabolism	1.16924922
40	MP0003283_abnormal_digestive_organ	1.15957143
41	MP0005076_abnormal_cell_differentiation	1.14941777
42	MP0005395_other_phenotype	1.13414592
43	MP0002102_abnormal_ear_morphology	1.11323744
44	MP0000013_abnormal_adipose_tissue	1.09200372
45	MP0005647_abnormal_sex_gland	1.07809671
46	MP0003943_abnormal_hepatobiliary_system	1.07156071
47	MP0002876_abnormal_thyroid_physiology	1.03970513
48	MP0005670_abnormal_white_adipose	1.02851465
49	MP0004145_abnormal_muscle_electrophysio	0.96040002
50	MP0009046_muscle_twitch	0.95810613
51	MP0005253_abnormal_eye_physiology	0.94330645
52	MP0002166_altered_tumor_susceptibility	0.92930364
53	MP0005075_abnormal_melanosome_morpholog	0.89911877
54	MP0003183_abnormal_peptide_metabolism	0.89571112
55	MP0008877_abnormal_DNA_methylation	0.88656466
56	MP0000538_abnormal_urinary_bladder	0.87731466
57	MP0010329_abnormal_lipoprotein_level	0.82648860
58	MP0002075_abnormal_coat/hair_pigmentati	0.81687685
59	MP0002332_abnormal_exercise_endurance	0.81413329
60	MP0002006_tumorigenesis	0.81231471
61	MP0005164_abnormal_response_to	0.80868668
62	MP0005376_homeostasis/metabolism_phenot	0.80480819
63	MP0004883_abnormal_blood_vessel	0.79881093
64	MP0005386_behavior/neurological_phenoty	0.79788144
65	MP0004924_abnormal_behavior	0.79788144
66	MP0005360_urolithiasis	0.78499665
67	MP0003632_abnormal_nervous_system	0.76950392
68	MP0005220_abnormal_exocrine_pancreas	0.74191787
69	MP0009115_abnormal_fat_cell	0.70642742
70	MP0001984_abnormal_olfaction	0.69829074
71	MP0004264_abnormal_extraembryonic_tissu	0.69627216
72	MP0004134_abnormal_chest_morphology	0.69443648
73	MP0001879_abnormal_lymphatic_vessel	0.68702100
74	MP0005365_abnormal_bile_salt	0.65685787
75	MP0001324_abnormal_eye_pigmentation	0.65561536
76	MP0001486_abnormal_startle_reflex	0.65522740
77	MP0003868_abnormal_feces_composition	0.65295462
78	MP0000372_irregular_coat_pigmentation	0.64962975
79	MP0003724_increased_susceptibility_to	0.63149310
80	MP0002127_abnormal_cardiovascular_syste	0.62843651
81	MP0001270_distended_abdomen	0.62793081
82	MP0001800_abnormal_humoral_immune	0.62124946
83	MP0000249_abnormal_blood_vessel	0.60618674
84	MP0004084_abnormal_cardiac_muscle	0.59787271
85	MP0000230_abnormal_systemic_arterial	0.59703318
86	MP0002396_abnormal_hematopoietic_system	0.59679032
87	MP0000470_abnormal_stomach_morphology	0.59163794
88	MP0004484_altered_response_of	0.58406962
89	MP0009764_decreased_sensitivity_to	0.56573034
90	MP0002108_abnormal_muscle_morphology	0.56504020
91	MP0002751_abnormal_autonomic_nervous	0.56095377
92	MP0002067_abnormal_sensory_capabilities	0.55521367
93	MP0001919_abnormal_reproductive_system	0.53860399
94	MP0001661_extended_life_span	0.52953172
95	MP0010352_gastrointestinal_tract_polyps	0.52160736
96	MP0008875_abnormal_xenobiotic_pharmacok	0.52073233
97	MP0008872_abnormal_physiological_respon	0.50854581
98	MP0003631_nervous_system_phenotype	0.50434886
99	MP0003633_abnormal_nervous_system	0.49946805
100	MP0003091_abnormal_cell_migration	0.49694432

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	4.89988020
2	Genetic anticipation (HP:0003743)	4.63514262
3	Fair hair (HP:0002286)	3.94606430
4	Clumsiness (HP:0002312)	3.84121563
5	Gaze-evoked nystagmus (HP:0000640)	3.73838611
6	Protruding tongue (HP:0010808)	3.67685198
7	Hypoplastic labia majora (HP:0000059)	3.67269658
8	Abnormality of the renal cortex (HP:0011035)	3.61486621
9	Chronic hepatic failure (HP:0100626)	3.55878551
10	Abnormality of the labia majora (HP:0012881)	3.43887099
11	Pancreatic cysts (HP:0001737)	3.39666403
12	Generalized hypopigmentation of hair (HP:0011358)	3.38101661
13	Congenital sensorineural hearing impairment (HP:0008527)	3.28028220
14	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.19277908
15	Widely spaced teeth (HP:0000687)	2.93153555
16	Absent speech (HP:0001344)	2.92239465
17	Progressive cerebellar ataxia (HP:0002073)	2.83367757
18	Enlarged kidneys (HP:0000105)	2.74454554
19	Renal cortical cysts (HP:0000803)	2.72088946
20	Stomach cancer (HP:0012126)	2.70359396
21	Abnormality of the nasal septum (HP:0000419)	2.69169525
22	Abnormality of the renal medulla (HP:0100957)	2.63442256
23	Short chin (HP:0000331)	2.60859504
24	Attenuation of retinal blood vessels (HP:0007843)	2.52739234
25	Febrile seizures (HP:0002373)	2.36432890
26	Pancreatic fibrosis (HP:0100732)	2.35860913
27	Blue irides (HP:0000635)	2.29230261
28	Decreased circulating renin level (HP:0003351)	2.21207526
29	Facial diplegia (HP:0001349)	2.19592881
30	Cupped ear (HP:0000378)	2.18307587
31	Arthropathy (HP:0003040)	2.14536762
32	Truncal obesity (HP:0001956)	2.13467481
33	Cerebellar dysplasia (HP:0007033)	2.12915363
34	Nephronophthisis (HP:0000090)	2.12640555
35	Abnormal pancreas size (HP:0012094)	2.12028397
36	Small hand (HP:0200055)	2.09301444
37	Prominent nose (HP:0000448)	2.08768656
38	True hermaphroditism (HP:0010459)	2.04986606
39	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.04838018
40	Thyroiditis (HP:0100646)	2.02157716
41	Labial hypoplasia (HP:0000066)	2.01288795
42	Lower limb hyperreflexia (HP:0002395)	2.00155495
43	Cystic liver disease (HP:0006706)	2.00138782
44	Acute myeloid leukemia (HP:0004808)	1.98231228
45	Abnormality of midbrain morphology (HP:0002418)	1.93265785
46	Molar tooth sign on MRI (HP:0002419)	1.93265785
47	Abnormality of the ischium (HP:0003174)	1.92892317
48	Subacute progressive viral hepatitis (HP:0006572)	1.91944372
49	Hyperkalemia (HP:0002153)	1.89131193
50	Sandal gap (HP:0001852)	1.89119646
51	Short foot (HP:0001773)	1.87298129
52	Narrow palate (HP:0000189)	1.84551028
53	Tented upper lip vermilion (HP:0010804)	1.84163158
54	Abnormality of chloride homeostasis (HP:0011422)	1.83897998
55	Congenital hepatic fibrosis (HP:0002612)	1.83566654
56	Dysmetric saccades (HP:0000641)	1.83493379
57	Volvulus (HP:0002580)	1.77878176
58	Highly arched eyebrow (HP:0002553)	1.77070883
59	Tubulointerstitial nephritis (HP:0001970)	1.77027965
60	T lymphocytopenia (HP:0005403)	1.75994165
61	Absent radius (HP:0003974)	1.74480998
62	Increased density of long bones (HP:0006392)	1.73372832
63	Bulbous nose (HP:0000414)	1.70699181
64	Preaxial foot polydactyly (HP:0001841)	1.70209993
65	Hypoplastic ischia (HP:0003175)	1.70121915
66	Abnormality of T cell number (HP:0011839)	1.69123574
67	Abnormality of secondary sexual hair (HP:0009888)	1.68808421
68	Abnormality of the axillary hair (HP:0100134)	1.68808421
69	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.67486538
70	Keratoconus (HP:0000563)	1.66804537
71	Increased corneal curvature (HP:0100692)	1.66804537
72	Increased number of teeth (HP:0011069)	1.66251295
73	Acanthocytosis (HP:0001927)	1.66227967
74	Clubbing of toes (HP:0100760)	1.64910557
75	Progressive inability to walk (HP:0002505)	1.63632407
76	Medial flaring of the eyebrow (HP:0010747)	1.63513922
77	Abnormality of chromosome stability (HP:0003220)	1.62795293
78	Portal hypertension (HP:0001409)	1.61730878
79	Hematochezia (HP:0002573)	1.61537475
80	Hepatoblastoma (HP:0002884)	1.61327208
81	Poikiloderma (HP:0001029)	1.61280242
82	Absent forearm bone (HP:0003953)	1.61148166
83	Aplasia involving forearm bones (HP:0009822)	1.61148166
84	Abnormal glucose tolerance (HP:0001952)	1.60796846
85	Tubulointerstitial abnormality (HP:0001969)	1.60763015
86	Prostate neoplasm (HP:0100787)	1.58489872
87	Hypoplastic nipples (HP:0002557)	1.57979629
88	Type II lissencephaly (HP:0007260)	1.57820326
89	Macroglossia (HP:0000158)	1.57657775
90	Neonatal hypoglycemia (HP:0001998)	1.56875092
91	Abnormality of the right ventricle (HP:0001707)	1.56337970
92	Hypoplastic female external genitalia (HP:0012815)	1.55593510
93	Abnormality of the pubic bones (HP:0003172)	1.55175108
94	Tapered finger (HP:0001182)	1.54918975
95	Abnormality of incisor morphology (HP:0011063)	1.54748542
96	Poor coordination (HP:0002370)	1.54313939
97	Rectal prolapse (HP:0002035)	1.54102548
98	Bony spicule pigmentary retinopathy (HP:0007737)	1.53944842
99	Hypopigmentation of the fundus (HP:0007894)	1.53291844
100	Wide intermamillary distance (HP:0006610)	1.52790907

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	8.24560235
2	ACVR1B	3.73349817
3	BMPR1B	3.20192908
4	AKT3	3.17095606
5	LATS1	2.43753758
6	TAOK3	2.28331625
7	NUAK1	2.09257250
8	LMTK2	1.79033692
9	CDK12	1.76260458
10	TXK	1.74457758
11	TLK1	1.71635481
12	STK38L	1.63603161
13	PIK3CA	1.63294646
14	BRD4	1.59164742
15	FGFR2	1.54688893
16	ZAK	1.50275080
17	MELK	1.47507191
18	BLK	1.40601729
19	ADRBK2	1.39261714
20	MAP3K4	1.35768712
21	PIK3CG	1.34389876
22	TRPM7	1.31558892
23	TEC	1.27255636
24	SGK2	1.25442332
25	MKNK2	1.23114142
26	MAPK13	1.17682577
27	TGFBR1	1.14474284
28	NLK	1.10798694
29	PDGFRB	1.06967404
30	PDGFRA	0.99911565
31	CAMK1D	0.97327560
32	JAK1	0.94382553
33	FER	0.93898850
34	WNK3	0.93156398
35	CAMK1G	0.89469804
36	MAPK11	0.89308755
37	BRSK2	0.87071496
38	WNK1	0.86484295
39	ADRBK1	0.84992301
40	PINK1	0.82455485
41	STK3	0.82103043
42	CAMKK2	0.80434039
43	INSRR	0.79120198
44	MAP3K14	0.77638092
45	DMPK	0.77228229
46	GRK1	0.77188856
47	EIF2AK3	0.75546411
48	PTK2B	0.72317660
49	PRKAA2	0.72198648
50	CHUK	0.71228875
51	RPS6KB2	0.71222727
52	MAP3K7	0.70891679
53	STK39	0.69233063
54	PAK3	0.68003375
55	MAPK7	0.67521314
56	STK38	0.66427859
57	MAP3K2	0.66061371
58	SGK3	0.64437735
59	FGFR3	0.63370618
60	SGK494	0.60005919
61	SGK223	0.60005919
62	MARK3	0.59687799
63	IKBKB	0.59116182
64	ITK	0.55189325
65	IKBKE	0.55142370
66	BTK	0.54727090
67	PRKAA1	0.53338383
68	NEK2	0.51689872
69	PRKCE	0.51438143
70	OBSCN	0.50121827
71	EEF2K	0.46522761
72	BCR	0.46420370
73	CAMK4	0.46170335
74	KIT	0.45548548
75	IRAK1	0.45326704
76	ERBB3	0.44822191
77	CDK8	0.44347954
78	TNK2	0.43498590
79	PRKCQ	0.42849594
80	YES1	0.41721228
81	NTRK3	0.40712313
82	MAP2K1	0.40633540
83	FLT3	0.39815143
84	MAP2K7	0.38815013
85	GRK7	0.37891849
86	OXSR1	0.37424099
87	MET	0.37259274
88	CSNK1A1L	0.36605018
89	EIF2AK2	0.35646728
90	TNIK	0.35335981
91	CSNK1D	0.35255496
92	MAPKAPK3	0.34499820
93	CASK	0.33795500
94	SYK	0.33344126
95	MTOR	0.33152921
96	MAPK1	0.32935268
97	MKNK1	0.32281119
98	CDK3	0.31568945
99	PDK2	0.30778210
100	WNK4	0.30004086

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	ABC transporters_Homo sapiens_hsa02010	2.83656544
2	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.91646907
3	Lysine degradation_Homo sapiens_hsa00310	1.91292567
4	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.87918215
5	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.71135888
6	Circadian rhythm_Homo sapiens_hsa04710	1.68794087
7	Linoleic acid metabolism_Homo sapiens_hsa00591	1.63416178
8	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.63001535
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.45563839
10	Butanoate metabolism_Homo sapiens_hsa00650	1.43813956
11	Taste transduction_Homo sapiens_hsa04742	1.43302804
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.39382282
13	Complement and coagulation cascades_Homo sapiens_hsa04610	1.37751504
14	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.35593878
15	Nitrogen metabolism_Homo sapiens_hsa00910	1.30718435
16	Selenocompound metabolism_Homo sapiens_hsa00450	1.27963060
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.25911738
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.23765622
19	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.23741104
20	Phototransduction_Homo sapiens_hsa04744	1.21268533
21	Nicotine addiction_Homo sapiens_hsa05033	1.21000537
22	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.18464359
23	Fanconi anemia pathway_Homo sapiens_hsa03460	1.17252110
24	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.16352632
25	Retinol metabolism_Homo sapiens_hsa00830	1.10364326
26	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.09049092
27	Histidine metabolism_Homo sapiens_hsa00340	1.06736750
28	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.05609141
29	Chemical carcinogenesis_Homo sapiens_hsa05204	1.05325947
30	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.04273978
31	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.03461877
32	FoxO signaling pathway_Homo sapiens_hsa04068	1.01970804
33	Ether lipid metabolism_Homo sapiens_hsa00565	1.01275621
34	Platelet activation_Homo sapiens_hsa04611	1.01053087
35	Homologous recombination_Homo sapiens_hsa03440	0.99911378
36	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.99484485
37	Morphine addiction_Homo sapiens_hsa05032	0.95287053
38	Calcium signaling pathway_Homo sapiens_hsa04020	0.94281282
39	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.92040239
40	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.91330105
41	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.89425385
42	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.88554992
43	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.84340910
44	Type II diabetes mellitus_Homo sapiens_hsa04930	0.83829287
45	Sphingolipid metabolism_Homo sapiens_hsa00600	0.83782645
46	Serotonergic synapse_Homo sapiens_hsa04726	0.81543090
47	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.76241726
48	MicroRNAs in cancer_Homo sapiens_hsa05206	0.74373493
49	mTOR signaling pathway_Homo sapiens_hsa04150	0.74329319
50	Insulin resistance_Homo sapiens_hsa04931	0.74184755
51	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.73945711
52	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.73247033
53	Renin secretion_Homo sapiens_hsa04924	0.73040052
54	Glycerolipid metabolism_Homo sapiens_hsa00561	0.72995727
55	Small cell lung cancer_Homo sapiens_hsa05222	0.72007552
56	Caffeine metabolism_Homo sapiens_hsa00232	0.71950753
57	Olfactory transduction_Homo sapiens_hsa04740	0.71023117
58	Circadian entrainment_Homo sapiens_hsa04713	0.68744509
59	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.68327462
60	cAMP signaling pathway_Homo sapiens_hsa04024	0.68270323
61	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.68212874
62	Bile secretion_Homo sapiens_hsa04976	0.67000162
63	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.65003940
64	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.64390269
65	Salivary secretion_Homo sapiens_hsa04970	0.62979584
66	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.62490143
67	Prostate cancer_Homo sapiens_hsa05215	0.61998661
68	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.61823754
69	ECM-receptor interaction_Homo sapiens_hsa04512	0.61732055
70	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.61557214
71	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.61439392
72	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.60215630
73	TNF signaling pathway_Homo sapiens_hsa04668	0.58930354
74	Prolactin signaling pathway_Homo sapiens_hsa04917	0.58652970
75	Graft-versus-host disease_Homo sapiens_hsa05332	0.58279332
76	beta-Alanine metabolism_Homo sapiens_hsa00410	0.58127319
77	Choline metabolism in cancer_Homo sapiens_hsa05231	0.57934120
78	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.57829007
79	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.56347858
80	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.55574728
81	Glutamatergic synapse_Homo sapiens_hsa04724	0.55295650
82	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.55288644
83	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.54751560
84	Cholinergic synapse_Homo sapiens_hsa04725	0.54386371
85	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.54018115
86	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.52759063
87	Melanoma_Homo sapiens_hsa05218	0.51384198
88	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.50781074
89	Non-small cell lung cancer_Homo sapiens_hsa05223	0.50239302
90	Focal adhesion_Homo sapiens_hsa04510	0.50082423
91	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.49546352
92	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.48853801
93	Gastric acid secretion_Homo sapiens_hsa04971	0.48319141
94	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.47771122
95	Basal transcription factors_Homo sapiens_hsa03022	0.47476508
96	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.46356139
97	Asthma_Homo sapiens_hsa05310	0.46326060
98	Glioma_Homo sapiens_hsa05214	0.45965226
99	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.45769859
100	Toxoplasmosis_Homo sapiens_hsa05145	0.45702673

PFN1P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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