PFN1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1succinate metabolic process (GO:0006105)8.35776543
2cytoplasmic mRNA processing body assembly (GO:0033962)7.82939912
3peptidyl-arginine omega-N-methylation (GO:0035247)6.85962548
4peptidyl-arginine N-methylation (GO:0035246)6.37488411
5peptidyl-arginine methylation (GO:0018216)6.37488411
6tricarboxylic acid cycle (GO:0006099)6.08534192
7positive regulation of mitochondrial fission (GO:0090141)5.91140983
8positive regulation of phosphoprotein phosphatase activity (GO:0032516)5.90004899
9positive regulation of B cell differentiation (GO:0045579)5.79404423
10coenzyme catabolic process (GO:0009109)5.24135887
11spermatid development (GO:0007286)5.23211547
12histone arginine methylation (GO:0034969)5.12561430
13activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO5.05612734
14regulation of mitochondrial depolarization (GO:0051900)5.03452627
15male sex determination (GO:0030238)4.91348554
16mitotic cell cycle arrest (GO:0071850)4.89308786
17ADP metabolic process (GO:0046031)4.73333413
18positive regulation of growth hormone secretion (GO:0060124)4.71984532
19nerve growth factor signaling pathway (GO:0038180)4.58878255
20sulfation (GO:0051923)4.42916523
21regulation of phosphoprotein phosphatase activity (GO:0043666)4.40774539
22negative regulation of activin receptor signaling pathway (GO:0032926)4.31990747
23glomerular visceral epithelial cell development (GO:0072015)4.31719142
24fibroblast migration (GO:0010761)4.29992207
25positive regulation of catecholamine secretion (GO:0033605)4.28624906
26relaxation of smooth muscle (GO:0044557)4.27073279
27regulation of mitochondrial fission (GO:0090140)4.09382203
28positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.02397621
29positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.94962129
30regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.94962129
31cellular response to zinc ion (GO:0071294)3.83537371
32regulation of glycogen (starch) synthase activity (GO:2000465)3.83473871
33positive regulation of protein homooligomerization (GO:0032464)3.81748841
34peptidyl-arginine modification (GO:0018195)3.81148130
35regulation of phospholipase A2 activity (GO:0032429)3.79336294
36activation of protein kinase B activity (GO:0032148)3.77524564
37urinary tract smooth muscle contraction (GO:0014848)3.76196487
38glomerular epithelial cell development (GO:0072310)3.73106422
39regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.69294056
40negative regulation of cell aging (GO:0090344)3.61963767
41negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.59909445
42granulocyte differentiation (GO:0030851)3.58408965
43lung-associated mesenchyme development (GO:0060484)3.56342082
44regulation of acyl-CoA biosynthetic process (GO:0050812)3.49968829
45negative regulation of DNA binding (GO:0043392)3.48217506
46mitochondrion degradation (GO:0000422)3.47107475
47regulation of protein homooligomerization (GO:0032462)3.46614607
48regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)3.42912519
49positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO3.42912519
50response to muscle activity (GO:0014850)3.41559527
51regulation of coenzyme metabolic process (GO:0051196)3.40087018
52regulation of cofactor metabolic process (GO:0051193)3.40087018
53peroxisome fission (GO:0016559)3.36512311
54oligosaccharide biosynthetic process (GO:0009312)3.28306983
55negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.27266933
56base-excision repair, AP site formation (GO:0006285)3.23690917
57pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.23027562
58negative regulation of epidermal cell differentiation (GO:0045605)3.21253420
59pyrimidine nucleotide catabolic process (GO:0006244)3.20645805
60protein K6-linked ubiquitination (GO:0085020)3.18730746
61epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.15607300
62DNA double-strand break processing (GO:0000729)3.07397006
63purine nucleoside diphosphate metabolic process (GO:0009135)3.06557841
64purine ribonucleoside diphosphate metabolic process (GO:0009179)3.06557841
65muscle cell cellular homeostasis (GO:0046716)3.05426425
66regulation of timing of cell differentiation (GO:0048505)3.05405583
67neuromuscular synaptic transmission (GO:0007274)3.01488499
68regulation of membrane depolarization (GO:0003254)3.00405099
69muscle organ morphogenesis (GO:0048644)2.99128920
70positive regulation of protein kinase C signaling (GO:0090037)2.98340156
71negative regulation of transcription regulatory region DNA binding (GO:2000678)2.95857982
72DNA integration (GO:0015074)2.95261907
73neuronal action potential (GO:0019228)2.94037863
74sex determination (GO:0007530)2.92196527
75motile cilium assembly (GO:0044458)2.91139161
76negative regulation of smooth muscle contraction (GO:0045986)2.88836002
77ER overload response (GO:0006983)2.88172720
78extrinsic apoptotic signaling pathway via death domain receptors (GO:0008625)2.88024178
79methionine biosynthetic process (GO:0009086)2.85367945
80positive regulation of receptor internalization (GO:0002092)2.85262788
81nucleotide phosphorylation (GO:0046939)2.81755334
82positive regulation of phosphatase activity (GO:0010922)2.77534132
83RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.76359199
84cofactor catabolic process (GO:0051187)2.76305366
85nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.75908978
86AMP metabolic process (GO:0046033)2.75741574
87protein import into peroxisome matrix (GO:0016558)2.75193802
88omega-hydroxylase P450 pathway (GO:0097267)2.74633380
89embryonic digestive tract development (GO:0048566)2.72782814
90negative regulation of organelle assembly (GO:1902116)2.72762651
91negative regulation of lipase activity (GO:0060192)2.71626664
92regulation of autophagic vacuole assembly (GO:2000785)2.70916202
93regulation of development, heterochronic (GO:0040034)2.68851389
94positive regulation of icosanoid secretion (GO:0032305)2.68530475
95behavioral response to nicotine (GO:0035095)2.67490458
96peristalsis (GO:0030432)2.67472452
97exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.67344431
98regulation of B cell differentiation (GO:0045577)2.65879813
99peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.64580122
100diacylglycerol metabolic process (GO:0046339)2.64466526

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.43409815
2GATA1_22025678_ChIP-Seq_K562_Human5.18381293
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse4.55996839
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.48343065
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.29380843
6GBX2_23144817_ChIP-Seq_PC3_Human4.01192927
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.77356381
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.36585410
9ESR1_20079471_ChIP-ChIP_T-47D_Human3.13332278
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.80215228
11VDR_22108803_ChIP-Seq_LS180_Human2.76957929
12ZNF274_21170338_ChIP-Seq_K562_Hela2.45405052
13IGF1R_20145208_ChIP-Seq_DFB_Human2.28759802
14CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.17293721
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.08870425
16POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.95157830
17TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.95157830
18CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.92261921
19NOTCH1_21737748_ChIP-Seq_TLL_Human1.91733526
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90997493
21ER_23166858_ChIP-Seq_MCF-7_Human1.87946895
22ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.74288488
23IRF1_19129219_ChIP-ChIP_H3396_Human1.62421640
24P300_19829295_ChIP-Seq_ESCs_Human1.59287427
25CBP_20019798_ChIP-Seq_JUKART_Human1.57453669
26IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.57453669
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.55221622
28KLF5_20875108_ChIP-Seq_MESCs_Mouse1.52669430
29ERA_21632823_ChIP-Seq_H3396_Human1.50175805
30CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.49442262
31RXR_22108803_ChIP-Seq_LS180_Human1.48968571
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47204006
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.44674165
34SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43911313
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38098373
36ESR1_15608294_ChIP-ChIP_MCF-7_Human1.31872828
37AR_21572438_ChIP-Seq_LNCaP_Human1.27318984
38WDR5_24793694_ChIP-Seq_LNCAP_Human1.27271681
39AUTS2_25519132_ChIP-Seq_293T-REX_Human1.24946761
40ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23046491
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21165525
42NCOR_22424771_ChIP-Seq_293T_Human1.20834089
43RAC3_21632823_ChIP-Seq_H3396_Human1.18768116
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18278073
45FOXH1_21741376_ChIP-Seq_EPCs_Human1.16208264
46CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.15988994
47PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.15454080
48MYC_19829295_ChIP-Seq_ESCs_Human1.15260277
49TCF4_23295773_ChIP-Seq_U87_Human1.14860978
50OCT4_20526341_ChIP-Seq_ESCs_Human1.13682285
51NANOG_20526341_ChIP-Seq_ESCs_Human1.12020671
52CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09704384
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09645249
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09024543
55CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08145806
56GABP_17652178_ChIP-ChIP_JURKAT_Human1.06813303
57BCAT_22108803_ChIP-Seq_LS180_Human1.05319314
58E2F1_17053090_ChIP-ChIP_MCF-7_Human1.04100810
59EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03716598
60SMAD4_21741376_ChIP-Seq_EPCs_Human1.03545987
61SMAD4_21799915_ChIP-Seq_A2780_Human1.00936060
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00043422
63POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98903183
64CJUN_26792858_Chip-Seq_BT549_Human0.98805367
65PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.98367530
66RAD21_21589869_ChIP-Seq_MESCs_Mouse0.97016188
67VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95840713
68ZNF263_19887448_ChIP-Seq_K562_Human0.94125541
69NFI_21473784_ChIP-Seq_ESCs_Mouse0.93838424
70TBL1_22424771_ChIP-Seq_293T_Human0.92924974
71SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.92312163
72TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91872907
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91855682
74EGR1_23403033_ChIP-Seq_LIVER_Mouse0.88898403
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87681981
76HOXB7_26014856_ChIP-Seq_BT474_Human0.87620210
77GATA3_21878914_ChIP-Seq_MCF-7_Human0.87444647
78MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85651491
79NFYB_21822215_ChIP-Seq_K562_Human0.84868913
80EZH2_27294783_Chip-Seq_ESCs_Mouse0.84126085
81SMAD3_21741376_ChIP-Seq_EPCs_Human0.84002335
82RNF2_18974828_ChIP-Seq_MESCs_Mouse0.83819835
83EZH2_18974828_ChIP-Seq_MESCs_Mouse0.83819835
84TCF4_22108803_ChIP-Seq_LS180_Human0.83262336
85GF1B_26923725_Chip-Seq_HPCs_Mouse0.82646017
86ELF5_23300383_ChIP-Seq_T47D_Human0.82093156
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.80756771
88STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.80116790
89SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79807410
90JARID2_20064375_ChIP-Seq_MESCs_Mouse0.79518321
91ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79329297
92GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.78804020
93RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.77966672
94MYC_18940864_ChIP-ChIP_HL60_Human0.76528821
95CBP_21632823_ChIP-Seq_H3396_Human0.76377516
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.76353325
97EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.75159673
98STAT1_17558387_ChIP-Seq_HELA_Human0.75064352
99RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.74521628
100AR_25329375_ChIP-Seq_VCAP_Human0.74476734

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis6.32492040
2MP0003806_abnormal_nucleotide_metabolis3.82605880
3MP0002132_abnormal_respiratory_system3.59838746
4MP0000749_muscle_degeneration3.23443322
5MP0003136_yellow_coat_color2.78867723
6MP0002102_abnormal_ear_morphology2.78692321
7MP0002822_catalepsy2.66326972
8MP0005365_abnormal_bile_salt2.62615705
9MP0009697_abnormal_copulation2.40445410
10MP0002837_dystrophic_cardiac_calcinosis2.38101931
11MP0001529_abnormal_vocalization2.37159055
12MP0000747_muscle_weakness2.29289669
13MP0003315_abnormal_perineum_morphology2.28908429
14MP0009780_abnormal_chondrocyte_physiolo2.26867834
15MP0003868_abnormal_feces_composition2.20197523
16MP0009840_abnormal_foam_cell2.19573599
17MP0006036_abnormal_mitochondrial_physio2.13227567
18MP0005646_abnormal_pituitary_gland2.13087496
19MP0008877_abnormal_DNA_methylation2.12053641
20MP0010386_abnormal_urinary_bladder2.06725672
21MP0000751_myopathy2.00810954
22MP0005085_abnormal_gallbladder_physiolo1.96443525
23MP0005394_taste/olfaction_phenotype1.96225921
24MP0005499_abnormal_olfactory_system1.96225921
25MP0002160_abnormal_reproductive_system1.81502785
26MP0005410_abnormal_fertilization1.76466808
27MP0009046_muscle_twitch1.74003688
28MP0008789_abnormal_olfactory_epithelium1.72352954
29MP0005058_abnormal_lysosome_morphology1.70402913
30MP0010368_abnormal_lymphatic_system1.67277483
31MP0000538_abnormal_urinary_bladder1.58532849
32MP0004084_abnormal_cardiac_muscle1.56974565
33MP0005171_absent_coat_pigmentation1.56045865
34MP0002751_abnormal_autonomic_nervous1.52701782
35MP0001299_abnormal_eye_distance/1.52071433
36MP0001485_abnormal_pinna_reflex1.43607641
37MP0008004_abnormal_stomach_pH1.43513540
38MP0006072_abnormal_retinal_apoptosis1.32342718
39MP0000049_abnormal_middle_ear1.31935147
40MP0003567_abnormal_fetal_cardiomyocyte1.31414896
41MP0003385_abnormal_body_wall1.29891982
42MP0003787_abnormal_imprinting1.29623263
43MP0005253_abnormal_eye_physiology1.29074122
44MP0001502_abnormal_circadian_rhythm1.19633944
45MP0001929_abnormal_gametogenesis1.18526937
46MP0004484_altered_response_of1.18048818
47MP0000537_abnormal_urethra_morphology1.17714774
48MP0004272_abnormal_basement_membrane1.15972847
49MP0005330_cardiomyopathy1.06993205
50MP0002127_abnormal_cardiovascular_syste1.06910593
51MP0000681_abnormal_thyroid_gland1.05667213
52MP0001664_abnormal_digestion1.04902045
53MP0001544_abnormal_cardiovascular_syste1.00933872
54MP0005385_cardiovascular_system_phenoty1.00933872
55MP0005551_abnormal_eye_electrophysiolog1.00185756
56MP0002233_abnormal_nose_morphology0.98213470
57MP0001501_abnormal_sleep_pattern0.96380384
58MP0001145_abnormal_male_reproductive0.95457374
59MP0002249_abnormal_larynx_morphology0.94849498
60MP0001968_abnormal_touch/_nociception0.93940003
61MP0003698_abnormal_male_reproductive0.92761294
62MP0001486_abnormal_startle_reflex0.91775851
63MP0006035_abnormal_mitochondrial_morpho0.91655555
64MP0002108_abnormal_muscle_morphology0.90516411
65MP0003942_abnormal_urinary_system0.89994467
66MP0002210_abnormal_sex_determination0.87584561
67MP0000631_abnormal_neuroendocrine_gland0.87370279
68MP0003936_abnormal_reproductive_system0.84043368
69MP0005360_urolithiasis0.83330638
70MP0005174_abnormal_tail_pigmentation0.82885007
71MP0005187_abnormal_penis_morphology0.82446695
72MP0000653_abnormal_sex_gland0.81872287
73MP0001661_extended_life_span0.81592347
74MP0004924_abnormal_behavior0.81364406
75MP0005386_behavior/neurological_phenoty0.81364406
76MP0003122_maternal_imprinting0.80710624
77MP0001270_distended_abdomen0.80509377
78MP0000343_altered_response_to0.80492418
79MP0001905_abnormal_dopamine_level0.78889623
80MP0004782_abnormal_surfactant_physiolog0.78072582
81MP0003755_abnormal_palate_morphology0.75604727
82MP0004036_abnormal_muscle_relaxation0.74435395
83MP0002932_abnormal_joint_morphology0.72910236
84MP0005248_abnormal_Harderian_gland0.71470399
85MP0000372_irregular_coat_pigmentation0.70373499
86MP0003938_abnormal_ear_development0.70364754
87MP0005389_reproductive_system_phenotype0.68825827
88MP0005620_abnormal_muscle_contractility0.67898492
89MP0002064_seizures0.66715565
90MP0000759_abnormal_skeletal_muscle0.66514606
91MP0005391_vision/eye_phenotype0.65071877
92MP0001756_abnormal_urination0.64376634
93MP0003880_abnormal_central_pattern0.64105304
94MP0002111_abnormal_tail_morphology0.64100921
95MP0002572_abnormal_emotion/affect_behav0.63926510
96MP0002269_muscular_atrophy0.63855904
97MP0009745_abnormal_behavioral_response0.63111355
98MP0001764_abnormal_homeostasis0.62981255
99MP0001984_abnormal_olfaction0.60866541
100MP0009764_decreased_sensitivity_to0.60675706

Predicted human phenotypes

RankGene SetZ-score
1Methylmalonic aciduria (HP:0012120)7.70467838
2Absent rod-and cone-mediated responses on ERG (HP:0007688)5.98348359
3Unsteady gait (HP:0002317)5.14913572
4Humeroradial synostosis (HP:0003041)4.50046984
5Synostosis involving the elbow (HP:0003938)4.50046984
6Reduced antithrombin III activity (HP:0001976)4.16233938
7Abnormality of dicarboxylic acid metabolism (HP:0010995)3.63716110
8Dicarboxylic aciduria (HP:0003215)3.63716110
9Abnormality of the columella (HP:0009929)3.45167739
10Decreased central vision (HP:0007663)3.42169109
11Abnormal rod and cone electroretinograms (HP:0008323)3.31135853
12Clumsiness (HP:0002312)3.28714137
13Amblyopia (HP:0000646)3.22309266
14Pheochromocytoma (HP:0002666)3.03267250
15Retinal dysplasia (HP:0007973)2.94723835
16Type II lissencephaly (HP:0007260)2.84219073
17Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.83777835
18Short middle phalanx of the 5th finger (HP:0004220)2.80622776
19Brushfield spots (HP:0001088)2.77036731
20Inability to walk (HP:0002540)2.75668375
21Nonimmune hydrops fetalis (HP:0001790)2.75552770
22Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.72558948
23Abnormal protein N-linked glycosylation (HP:0012347)2.72558948
24Abnormal protein glycosylation (HP:0012346)2.72558948
25Abnormal glycosylation (HP:0012345)2.72558948
26Pancreatic cysts (HP:0001737)2.68657278
27Attenuation of retinal blood vessels (HP:0007843)2.66838457
28Capillary hemangiomas (HP:0005306)2.66167714
29Cubitus valgus (HP:0002967)2.65595116
30Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.63263122
31Type I transferrin isoform profile (HP:0003642)2.62070707
32Facial hemangioma (HP:0000329)2.60211307
33Ketosis (HP:0001946)2.60104966
34Protruding tongue (HP:0010808)2.55460316
35Enlarged kidneys (HP:0000105)2.53239644
36Neuroendocrine neoplasm (HP:0100634)2.46244130
37Hypoplasia of the thymus (HP:0000778)2.45266459
38Short 5th finger (HP:0009237)2.39636644
39Conjunctival hamartoma (HP:0100780)2.38962658
40Gaze-evoked nystagmus (HP:0000640)2.38342269
41Atonic seizures (HP:0010819)2.37788950
42Turricephaly (HP:0000262)2.36035885
43Hamartoma of the eye (HP:0010568)2.35557489
44Abnormality of the intrinsic pathway (HP:0010989)2.34833665
45Meningioma (HP:0002858)2.34165013
46Large for gestational age (HP:0001520)2.33020049
47Hypophosphatemia (HP:0002148)2.32843223
48Optic nerve hypoplasia (HP:0000609)2.32149344
49Symphalangism affecting the phalanges of the hand (HP:0009773)2.26490242
50Abnormality of the shoulder girdle musculature (HP:0001435)2.22886079
51Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.19705262
52Benign neoplasm of the central nervous system (HP:0100835)2.19607693
53Febrile seizures (HP:0002373)2.17374074
54Cerebral hemorrhage (HP:0001342)2.14634539
55Cerebral hypomyelination (HP:0006808)2.10466120
56Chronic hepatic failure (HP:0100626)2.09911949
57Delayed gross motor development (HP:0002194)2.06272057
58Absent speech (HP:0001344)2.04766538
59Scapular winging (HP:0003691)2.02810139
60Hyperventilation (HP:0002883)12.4918869
61Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.99646929
62Pancreatic fibrosis (HP:0100732)1.98773358
63Respiratory failure (HP:0002878)1.96837764
64Cerebellar dysplasia (HP:0007033)1.96731648
65Abnormality of the frontal sinuses (HP:0002687)1.96545238
66Pancreatic islet-cell hyperplasia (HP:0004510)1.94860043
67Intellectual disability, severe (HP:0010864)1.94293811
68True hermaphroditism (HP:0010459)1.93950456
69Hyporeflexia of lower limbs (HP:0002600)1.92825101
70Abnormal pancreas size (HP:0012094)1.92586313
71Clitoromegaly (HP:0000057)1.92190711
72Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.91530352
73Retinal atrophy (HP:0001105)1.88983940
74Bile duct proliferation (HP:0001408)1.88451806
75Abnormal biliary tract physiology (HP:0012439)1.88451806
76Exercise-induced muscle cramps (HP:0003710)1.86104412
77Bone cyst (HP:0012062)1.83839934
78Abnormal respiratory motile cilium physiology (HP:0012261)1.81826717
79High anterior hairline (HP:0009890)1.79793731
80Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.79780128
81Decreased activity of mitochondrial respiratory chain (HP:0008972)1.79780128
82Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78466647
83Cystic liver disease (HP:0006706)1.77441891
84Progressive inability to walk (HP:0002505)1.75806685
85Abnormality of the pancreatic islet cells (HP:0006476)1.75478223
86Abnormality of endocrine pancreas physiology (HP:0012093)1.75478223
87Facial diplegia (HP:0001349)1.75398053
88Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.72869362
89Eosinophilia (HP:0001880)1.71653846
90Long foot (HP:0001833)1.71292294
91Supernumerary spleens (HP:0009799)1.67071760
92Hypoplastic iliac wings (HP:0002866)1.66458324
93Acanthocytosis (HP:0001927)1.66210101
94Upper limb muscle weakness (HP:0003484)1.64172362
95Congenital sensorineural hearing impairment (HP:0008527)1.62634380
96Abnormality of lateral ventricle (HP:0030047)1.62583405
97Reticulocytosis (HP:0001923)1.61115959
98Tetraparesis (HP:0002273)1.60967051
99Absent/shortened dynein arms (HP:0200106)1.58779561
100Dynein arm defect of respiratory motile cilia (HP:0012255)1.58779561

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK16.49141456
2CDK85.19453940
3MARK33.82242455
4CSNK1A1L2.98875563
5MAP3K42.90743358
6CSNK1G32.74942671
7OBSCN2.72241539
8FRK2.54779083
9CSNK1G22.28441441
10LATS12.24974682
11CSNK1G12.17180915
12NEK22.16032210
13BCKDK2.15877132
14DYRK32.08373322
15MAP2K72.03177983
16MOS2.01966649
17MYLK1.91788827
18PDK21.83891848
19EIF2AK31.68736744
20STK38L1.66745575
21ZAK1.61401793
22MAPK151.57258076
23CLK11.53401371
24BMPR1B1.48496336
25GRK51.42978198
26EPHB11.36700734
27DYRK1B1.36673982
28CASK1.28018512
29GRK71.18875816
30SGK2231.15530741
31SGK4941.15530741
32TIE11.14625384
33MAP3K71.13866996
34TGFBR21.12103295
35DYRK21.10914556
36MARK11.04294307
37CDK30.96047845
38GRK10.93774025
39RPS6KA50.91722124
40KDR0.89776432
41ADRBK20.86610897
42CDK190.78625253
43SGK20.77850251
44PAK30.77069739
45BRD40.76665650
46MAPK130.74788395
47TGFBR10.74788382
48PKN20.71667290
49STK380.70199652
50RPS6KA40.69912895
51FGFR20.68285574
52MAPK120.64504160
53PRKCQ0.59588169
54TLK10.58455406
55MAPKAPK50.57414893
56NME20.57081088
57RPS6KB10.56779181
58PIK3CA0.54528422
59CSNK1A10.53673485
60MAP3K100.51034150
61PAK20.49375201
62CSNK1D0.48690217
63CAMK10.48372106
64CAMK40.47606787
65ROCK10.46535086
66PKN10.44675100
67PAK10.44447274
68PRKCI0.41142948
69MELK0.33950341
70CDK140.33841248
71SGK30.33507757
72ADRBK10.32385261
73CDK120.32156411
74LATS20.31181645
75ACVR1B0.30828683
76NUAK10.29687217
77BCR0.29571433
78STK30.29545351
79DAPK30.28475810
80MAPKAPK30.28284789
81RPS6KA60.28284231
82STK40.26897585
83PDK10.26321340
84ILK0.26207983
85BTK0.26063211
86CDK50.25848036
87PRKG10.24458547
88STK110.23612776
89EGFR0.23381168
90VRK10.22782245
91CAMK2D0.21567025
92PRKG20.21230252
93RET0.20648056
94MAP3K10.20552940
95MUSK0.20315039
96PTK2B0.20185711
97PRKCG0.19232526
98MAP3K130.19198086
99PDPK10.18375738
100AKT30.16442217

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000206.72690989
2Propanoate metabolism_Homo sapiens_hsa006406.01577262
3Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.57422122
4Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.40612528
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.39384135
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.35975486
7Olfactory transduction_Homo sapiens_hsa047402.32809835
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.24163692
9Nitrogen metabolism_Homo sapiens_hsa009102.06722471
10Carbon metabolism_Homo sapiens_hsa012001.91179171
11Chemical carcinogenesis_Homo sapiens_hsa052041.89201256
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.77219209
13RNA degradation_Homo sapiens_hsa030181.71563948
14Phototransduction_Homo sapiens_hsa047441.60131039
15Proteasome_Homo sapiens_hsa030501.58571652
16Steroid hormone biosynthesis_Homo sapiens_hsa001401.57152672
17Basal transcription factors_Homo sapiens_hsa030221.41861519
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37622286
19Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.29515825
20Butanoate metabolism_Homo sapiens_hsa006501.29446159
21beta-Alanine metabolism_Homo sapiens_hsa004101.23694556
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.20126530
23Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.18605094
24Regulation of autophagy_Homo sapiens_hsa041401.17759140
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14206556
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.12372942
27ABC transporters_Homo sapiens_hsa020101.12284462
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.11567119
29Fanconi anemia pathway_Homo sapiens_hsa034601.11428758
30Peroxisome_Homo sapiens_hsa041461.10210283
31Circadian rhythm_Homo sapiens_hsa047101.06217584
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.02340128
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.00686868
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98429078
35Sphingolipid signaling pathway_Homo sapiens_hsa040710.94538933
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93608229
37RNA polymerase_Homo sapiens_hsa030200.89675081
38AMPK signaling pathway_Homo sapiens_hsa041520.89268635
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87385506
40Mineral absorption_Homo sapiens_hsa049780.84769538
41Retinol metabolism_Homo sapiens_hsa008300.83109597
42Pyrimidine metabolism_Homo sapiens_hsa002400.80281734
43Vascular smooth muscle contraction_Homo sapiens_hsa042700.80258841
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79988277
45Nucleotide excision repair_Homo sapiens_hsa034200.79303657
46mRNA surveillance pathway_Homo sapiens_hsa030150.78613373
47Sphingolipid metabolism_Homo sapiens_hsa006000.75539666
48Arginine biosynthesis_Homo sapiens_hsa002200.75493828
49Fructose and mannose metabolism_Homo sapiens_hsa000510.75221433
50Drug metabolism - other enzymes_Homo sapiens_hsa009830.74737890
51Arachidonic acid metabolism_Homo sapiens_hsa005900.74453899
52Purine metabolism_Homo sapiens_hsa002300.74300491
53Circadian entrainment_Homo sapiens_hsa047130.72668394
54Taste transduction_Homo sapiens_hsa047420.72374577
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72123124
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70884446
57Apoptosis_Homo sapiens_hsa042100.69172498
58Glycosaminoglycan degradation_Homo sapiens_hsa005310.68974859
59Gap junction_Homo sapiens_hsa045400.68299180
60Salivary secretion_Homo sapiens_hsa049700.67258414
61Calcium signaling pathway_Homo sapiens_hsa040200.66596920
62Linoleic acid metabolism_Homo sapiens_hsa005910.65570366
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65328478
64Galactose metabolism_Homo sapiens_hsa000520.63735328
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.61956383
66TGF-beta signaling pathway_Homo sapiens_hsa043500.61206999
67Melanoma_Homo sapiens_hsa052180.59587640
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59174762
69Renin secretion_Homo sapiens_hsa049240.58583371
70Metabolic pathways_Homo sapiens_hsa011000.57768365
71Phenylalanine metabolism_Homo sapiens_hsa003600.57500165
72Dopaminergic synapse_Homo sapiens_hsa047280.56212312
73One carbon pool by folate_Homo sapiens_hsa006700.55946855
74Base excision repair_Homo sapiens_hsa034100.52931801
75Hedgehog signaling pathway_Homo sapiens_hsa043400.52713233
76PPAR signaling pathway_Homo sapiens_hsa033200.52639949
77Systemic lupus erythematosus_Homo sapiens_hsa053220.49537688
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48536861
79Tyrosine metabolism_Homo sapiens_hsa003500.45369113
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44080494
81Alcoholism_Homo sapiens_hsa050340.43018037
82GABAergic synapse_Homo sapiens_hsa047270.41792344
83Pancreatic secretion_Homo sapiens_hsa049720.41471991
84Parkinsons disease_Homo sapiens_hsa050120.41151725
85Starch and sucrose metabolism_Homo sapiens_hsa005000.38293533
86PI3K-Akt signaling pathway_Homo sapiens_hsa041510.36664075
87Mismatch repair_Homo sapiens_hsa034300.36524718
88Tight junction_Homo sapiens_hsa045300.35901966
89Protein digestion and absorption_Homo sapiens_hsa049740.33154276
90Oxytocin signaling pathway_Homo sapiens_hsa049210.32815945
91Other glycan degradation_Homo sapiens_hsa005110.31957959
92Fat digestion and absorption_Homo sapiens_hsa049750.31398619
93Phagosome_Homo sapiens_hsa041450.29018571
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.28096106
95N-Glycan biosynthesis_Homo sapiens_hsa005100.27873519
96Complement and coagulation cascades_Homo sapiens_hsa046100.26697938
97Alzheimers disease_Homo sapiens_hsa050100.26639250
98Glucagon signaling pathway_Homo sapiens_hsa049220.25341203
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24805505
100Oxidative phosphorylation_Homo sapiens_hsa001900.24400168

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