ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial DNA replication (GO:0006264)	8.73381922
2	mitochondrial DNA metabolic process (GO:0032042)	5.84236550
3	sequestering of actin monomers (GO:0042989)	5.76641681
4	DNA-dependent DNA replication (GO:0006261)	5.37112661
5	T cell apoptotic process (GO:0070231)	4.80918200
6	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	4.59806257
7	thalamus development (GO:0021794)	4.50620693
8	viral transcription (GO:0019083)	4.46473032
9	neuron fate determination (GO:0048664)	4.41679859
10	translational termination (GO:0006415)	4.27473799
11	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	4.24027460
12	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.89595017
13	cotranslational protein targeting to membrane (GO:0006613)	3.88977653
14	protein targeting to ER (GO:0045047)	3.87899982
15	lymphocyte apoptotic process (GO:0070227)	3.86946885
16	intraciliary transport (GO:0042073)	3.78554783
17	positive regulation of gastrulation (GO:2000543)	3.74236599
18	protein localization to endoplasmic reticulum (GO:0070972)	3.72033017
19	negative regulation of cell cycle G2/M phase transition (GO:1902750)	3.67826576
20	ribosomal small subunit biogenesis (GO:0042274)	3.67551589
21	somite rostral/caudal axis specification (GO:0032525)	3.66816053
22	limb bud formation (GO:0060174)	3.63236973
23	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.62583542
24	pyrimidine nucleobase catabolic process (GO:0006208)	3.58393378
25	otic vesicle formation (GO:0030916)	3.57164194
26	CENP-A containing nucleosome assembly (GO:0034080)	3.55881760
27	translational elongation (GO:0006414)	3.53634390
28	urinary tract smooth muscle contraction (GO:0014848)	3.53312824
29	anterograde synaptic vesicle transport (GO:0048490)	3.50235726
30	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.49973042
31	platelet dense granule organization (GO:0060155)	3.46256500
32	chromatin remodeling at centromere (GO:0031055)	3.45848691
33	rRNA modification (GO:0000154)	3.45433165
34	positive regulation of catecholamine secretion (GO:0033605)	3.43924110
35	protein localization to cilium (GO:0061512)	3.41896725
36	somite development (GO:0061053)	3.40998877
37	behavioral response to nicotine (GO:0035095)	3.39935377
38	ribosomal small subunit assembly (GO:0000028)	3.36084480
39	histone exchange (GO:0043486)	3.30320407
40	negative regulation of transcription by competitive promoter binding (GO:0010944)	3.29403024
41	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.19945453
42	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.19480915
43	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.19480915
44	NADH dehydrogenase complex assembly (GO:0010257)	3.19480915
45	cellular protein complex disassembly (GO:0043624)	3.12731498
46	DNA double-strand break processing (GO:0000729)	3.12466988
47	cGMP biosynthetic process (GO:0006182)	3.11651794
48	S-adenosylmethionine metabolic process (GO:0046500)	3.08273967
49	viral life cycle (GO:0019058)	3.06695953
50	multicellular organism reproduction (GO:0032504)	3.06507854
51	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.99249936
52	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.99249936
53	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.99249936
54	kinetochore assembly (GO:0051382)	2.95245610
55	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.94932313
56	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.93011692
57	epithelial cilium movement (GO:0003351)	2.91152612
58	serine family amino acid catabolic process (GO:0009071)	2.88854123
59	aspartate family amino acid catabolic process (GO:0009068)	2.88526034
60	left/right pattern formation (GO:0060972)	2.88084719
61	activation of protein kinase B activity (GO:0032148)	2.86141199
62	translational initiation (GO:0006413)	2.85962228
63	regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)	2.83726680
64	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.83181550
65	leukocyte apoptotic process (GO:0071887)	2.79653271
66	centriole replication (GO:0007099)	2.76956156
67	embryonic digestive tract morphogenesis (GO:0048557)	2.76122833
68	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.75625158
69	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	2.72547648
70	primitive streak formation (GO:0090009)	2.71392623
71	synapsis (GO:0007129)	2.70585965
72	retinal ganglion cell axon guidance (GO:0031290)	2.69256746
73	regulation of dopamine secretion (GO:0014059)	2.68917643
74	receptor guanylyl cyclase signaling pathway (GO:0007168)	2.67231158
75	negative regulation of interleukin-1 beta production (GO:0032691)	2.66932826
76	protein complex disassembly (GO:0043241)	2.66656502
77	cornea development in camera-type eye (GO:0061303)	2.65584367
78	positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)	2.65281375
79	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.63191437
80	rRNA catabolic process (GO:0016075)	2.63013522
81	coenzyme catabolic process (GO:0009109)	2.60814307
82	rRNA methylation (GO:0031167)	2.60568050
83	AMP metabolic process (GO:0046033)	2.59947953
84	peroxisome fission (GO:0016559)	2.59841488
85	oocyte maturation (GO:0001556)	2.59344353
86	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.58638137
87	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.57862040
88	cranial nerve morphogenesis (GO:0021602)	2.55660748
89	response to muscle activity (GO:0014850)	2.54611789
90	methionine biosynthetic process (GO:0009086)	2.53440101
91	embryonic axis specification (GO:0000578)	2.52177588
92	centriole assembly (GO:0098534)	2.51548294
93	negative regulation of cytokine-mediated signaling pathway (GO:0001960)	2.51425592
94	negative regulation of DNA binding (GO:0043392)	2.50899439
95	macromolecular complex disassembly (GO:0032984)	2.50808860
96	T cell differentiation in thymus (GO:0033077)	2.50711282
97	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.50289370
98	negative regulation of macrophage differentiation (GO:0045650)	2.50116986
99	nucleobase catabolic process (GO:0046113)	2.48598155
100	phasic smooth muscle contraction (GO:0014821)	2.47802049

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	7.32152344
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.23476661
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.92047321
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.89202759
5	EZH2_22144423_ChIP-Seq_EOC_Human	3.39135076
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.11749368
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.88731749
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.81192261
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.65291092
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.63544824
11	VDR_22108803_ChIP-Seq_LS180_Human	2.59930152
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.50342879
13	EWS_26573619_Chip-Seq_HEK293_Human	2.43445503
14	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.32711248
15	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.15735900
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.01711934
17	GBX2_23144817_ChIP-Seq_PC3_Human	1.97996848
18	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.89134731
19	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.86940965
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.86574410
21	P300_19829295_ChIP-Seq_ESCs_Human	1.86417142
22	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.74935703
23	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.71593294
24	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.68925377
25	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.67378227
26	FUS_26573619_Chip-Seq_HEK293_Human	1.63620767
27	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.61122649
28	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.60822294
29	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.58992073
30	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.58121314
31	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.57572293
32	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.56244521
33	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.54572136
34	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.51382875
35	ELK1_19687146_ChIP-ChIP_HELA_Human	1.50416176
36	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.49810103
37	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.47651543
38	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.47651543
39	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.46740717
40	VDR_23849224_ChIP-Seq_CD4+_Human	1.45557595
41	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.43640684
42	DCP1A_22483619_ChIP-Seq_HELA_Human	1.43373345
43	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.42457825
44	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.41669763
45	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.39416923
46	MYC_18940864_ChIP-ChIP_HL60_Human	1.36899746
47	FOXP3_21729870_ChIP-Seq_TREG_Human	1.31929306
48	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.31647726
49	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.29503713
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.28763884
51	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.26987384
52	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.26547545
53	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.25357064
54	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.21780911
55	RUNX2_22187159_ChIP-Seq_PCA_Human	1.20291531
56	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.13119001
57	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.12286193
58	CBP_20019798_ChIP-Seq_JUKART_Human	1.12118575
59	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.12118575
60	ERA_21632823_ChIP-Seq_H3396_Human	1.11679009
61	NCOR_22424771_ChIP-Seq_293T_Human	1.09542466
62	NANOG_19829295_ChIP-Seq_ESCs_Human	1.09164037
63	SOX2_19829295_ChIP-Seq_ESCs_Human	1.09164037
64	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.08584844
65	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.08336396
66	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.06617562
67	NANOG_20526341_ChIP-Seq_ESCs_Human	1.06559501
68	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.04778619
69	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.04521553
70	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.03716588
71	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.02090700
72	TCF4_22108803_ChIP-Seq_LS180_Human	1.02049238
73	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.01901945
74	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.99875263
75	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.97150125
76	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.96960223
77	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	0.96641885
78	AR_21572438_ChIP-Seq_LNCaP_Human	0.95227738
79	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.94287368
80	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.93549404
81	RNF2_27304074_Chip-Seq_NSC_Mouse	0.92242957
82	TAF15_26573619_Chip-Seq_HEK293_Human	0.92115741
83	BCAT_22108803_ChIP-Seq_LS180_Human	0.91163856
84	IRF1_19129219_ChIP-ChIP_H3396_Human	0.90098895
85	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.89029739
86	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.88748321
87	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.87971931
88	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.87396026
89	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.86908802
90	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.86588499
91	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.86290761
92	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.84971790
93	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.84657119
94	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.83899398
95	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.83410088
96	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.83410088
97	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.82348607
98	AR_20517297_ChIP-Seq_VCAP_Human	0.82246344
99	XRN2_22483619_ChIP-Seq_HELA_Human	0.81295035
100	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.79534329

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	5.42204129
2	MP0001529_abnormal_vocalization	3.56194953
3	MP0002102_abnormal_ear_morphology	3.49785680
4	MP0003283_abnormal_digestive_organ	3.15471240
5	MP0002822_catalepsy	2.74799097
6	MP0010030_abnormal_orbit_morphology	2.61085436
7	MP0002160_abnormal_reproductive_system	2.55030829
8	MP0002638_abnormal_pupillary_reflex	2.49943397
9	MP0003315_abnormal_perineum_morphology	2.44603533
10	MP0005084_abnormal_gallbladder_morpholo	2.24107188
11	MP0006035_abnormal_mitochondrial_morpho	2.17230917
12	MP0006292_abnormal_olfactory_placode	2.13762824
13	MP0002938_white_spotting	2.07844205
14	MP0006072_abnormal_retinal_apoptosis	2.05282241
15	MP0009379_abnormal_foot_pigmentation	2.02200771
16	MP0005499_abnormal_olfactory_system	2.01330081
17	MP0005394_taste/olfaction_phenotype	2.01330081
18	MP0006138_congestive_heart_failure	2.00413050
19	MP0003806_abnormal_nucleotide_metabolis	1.97425829
20	MP0000015_abnormal_ear_pigmentation	1.94533698
21	MP0002234_abnormal_pharynx_morphology	1.91307671
22	MP0008789_abnormal_olfactory_epithelium	1.87477115
23	MP0005174_abnormal_tail_pigmentation	1.80086370
24	MP0009840_abnormal_foam_cell	1.79851973
25	MP0003890_abnormal_embryonic-extraembry	1.60169905
26	MP0001188_hyperpigmentation	1.59862518
27	MP0008058_abnormal_DNA_repair	1.58101294
28	MP0003221_abnormal_cardiomyocyte_apopto	1.56289150
29	MP0006036_abnormal_mitochondrial_physio	1.54830641
30	MP0004133_heterotaxia	1.53002088
31	MP0001293_anophthalmia	1.52999876
32	MP0005377_hearing/vestibular/ear_phenot	1.47789974
33	MP0003878_abnormal_ear_physiology	1.47789974
34	MP0005171_absent_coat_pigmentation	1.44854440
35	MP0004381_abnormal_hair_follicle	1.44829770
36	MP0010386_abnormal_urinary_bladder	1.43533055
37	MP0005248_abnormal_Harderian_gland	1.41145959
38	MP0005389_reproductive_system_phenotype	1.39504128
39	MP0000372_irregular_coat_pigmentation	1.39060713
40	MP0008995_early_reproductive_senescence	1.38557055
41	MP0005330_cardiomyopathy	1.37159071
42	MP0001485_abnormal_pinna_reflex	1.36495771
43	MP0002127_abnormal_cardiovascular_syste	1.35313524
44	MP0001984_abnormal_olfaction	1.34574128
45	MP0002132_abnormal_respiratory_system	1.30154384
46	MP0002249_abnormal_larynx_morphology	1.29436792
47	MP0002095_abnormal_skin_pigmentation	1.25919700
48	MP0003567_abnormal_fetal_cardiomyocyte	1.25394329
49	MP0001905_abnormal_dopamine_level	1.24418702
50	MP0002735_abnormal_chemical_nociception	1.23154828
51	MP0005410_abnormal_fertilization	1.22725782
52	MP0005646_abnormal_pituitary_gland	1.22601431
53	MP0000569_abnormal_digit_pigmentation	1.21975653
54	MP0002233_abnormal_nose_morphology	1.21350388
55	MP0003880_abnormal_central_pattern	1.20630243
56	MP0005253_abnormal_eye_physiology	1.18360409
57	MP0003938_abnormal_ear_development	1.13233326
58	MP0001486_abnormal_startle_reflex	1.11193657
59	MP0002751_abnormal_autonomic_nervous	1.10179318
60	MP0002282_abnormal_trachea_morphology	1.09169361
61	MP0010094_abnormal_chromosome_stability	1.08794722
62	MP0001986_abnormal_taste_sensitivity	1.08253042
63	MP0005075_abnormal_melanosome_morpholog	1.07662317
64	MP0001299_abnormal_eye_distance/	1.01886085
65	MP0001346_abnormal_lacrimal_gland	0.96602190
66	MP0005551_abnormal_eye_electrophysiolog	0.95693980
67	MP0001929_abnormal_gametogenesis	0.94202000
68	MP0008004_abnormal_stomach_pH	0.93891104
69	MP0002876_abnormal_thyroid_physiology	0.92971577
70	MP0005391_vision/eye_phenotype	0.91324670
71	MP0000566_synostosis	0.89475878
72	MP0005385_cardiovascular_system_phenoty	0.88887727
73	MP0001544_abnormal_cardiovascular_syste	0.88887727
74	MP0005408_hypopigmentation	0.85365892
75	MP0000749_muscle_degeneration	0.84582459
76	MP0008875_abnormal_xenobiotic_pharmacok	0.83426290
77	MP0000049_abnormal_middle_ear	0.82955507
78	MP0005503_abnormal_tendon_morphology	0.82875462
79	MP0003077_abnormal_cell_cycle	0.80554193
80	MP0003119_abnormal_digestive_system	0.80035603
81	MP0004084_abnormal_cardiac_muscle	0.79684349
82	MP0000631_abnormal_neuroendocrine_gland	0.77681001
83	MP0001968_abnormal_touch/_nociception	0.77569957
84	MP0002210_abnormal_sex_determination	0.77480102
85	MP0001324_abnormal_eye_pigmentation	0.77206667
86	MP0003385_abnormal_body_wall	0.77075041
87	MP0005085_abnormal_gallbladder_physiolo	0.75901272
88	MP0001764_abnormal_homeostasis	0.75271488
89	MP0003698_abnormal_male_reproductive	0.74440749
90	MP0000026_abnormal_inner_ear	0.72956135
91	MP0001270_distended_abdomen	0.71797810
92	MP0002837_dystrophic_cardiac_calcinosis	0.68698121
93	MP0001286_abnormal_eye_development	0.67824075
94	MP0000538_abnormal_urinary_bladder	0.67448553
95	MP0004742_abnormal_vestibular_system	0.66494571
96	MP0005670_abnormal_white_adipose	0.65372248
97	MP0005187_abnormal_penis_morphology	0.64736751
98	MP0004215_abnormal_myocardial_fiber	0.62396455
99	MP0002932_abnormal_joint_morphology	0.62182067
100	MP0003755_abnormal_palate_morphology	0.62067029

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Colon cancer (HP:0003003)	3.98854868
2	Congenital stationary night blindness (HP:0007642)	3.88198750
3	Poor head control (HP:0002421)	3.52376231
4	Reticulocytopenia (HP:0001896)	3.49084894
5	Reduced antithrombin III activity (HP:0001976)	3.47555244
6	Acute necrotizing encephalopathy (HP:0006965)	3.40337865
7	Lipid accumulation in hepatocytes (HP:0006561)	3.21061032
8	Acute encephalopathy (HP:0006846)	3.10570214
9	Congenital, generalized hypertrichosis (HP:0004540)	3.08582626
10	Hyperglycinemia (HP:0002154)	3.00053266
11	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.93353691
12	Abnormality of alanine metabolism (HP:0010916)	2.84251912
13	Hyperalaninemia (HP:0003348)	2.84251912
14	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.84251912
15	Increased hepatocellular lipid droplets (HP:0006565)	2.76391172
16	Constricted visual fields (HP:0001133)	2.69058166
17	Abnormal mitochondria in muscle tissue (HP:0008316)	2.68131589
18	Abolished electroretinogram (ERG) (HP:0000550)	2.67723955
19	Mitochondrial inheritance (HP:0001427)	2.62852656
20	True hermaphroditism (HP:0010459)	2.59654513
21	Sex reversal (HP:0012245)	2.59296381
22	Abnormal sex determination (HP:0012244)	2.59296381
23	Progressive macrocephaly (HP:0004481)	2.57708539
24	Pigmentary retinal degeneration (HP:0001146)	2.56421579
25	Cerebellar dysplasia (HP:0007033)	2.48856817
26	Meckel diverticulum (HP:0002245)	2.45358055
27	Abnormal respiratory motile cilium physiology (HP:0012261)	2.39833650
28	Abnormality of the ileum (HP:0001549)	2.39405715
29	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.38050751
30	Duplicated collecting system (HP:0000081)	2.36478967
31	Oligodactyly (hands) (HP:0001180)	2.35979687
32	Type I transferrin isoform profile (HP:0003642)	2.33516553
33	Abnormality of DNA repair (HP:0003254)	2.31970810
34	Macrocytic anemia (HP:0001972)	2.31919653
35	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.31796550
36	Congenital sensorineural hearing impairment (HP:0008527)	2.31083315
37	Increased CSF lactate (HP:0002490)	2.25475625
38	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.25161978
39	Abnormal protein N-linked glycosylation (HP:0012347)	2.25161978
40	Abnormal protein glycosylation (HP:0012346)	2.25161978
41	Abnormal glycosylation (HP:0012345)	2.25161978
42	Meningioma (HP:0002858)	2.23211932
43	Abnormal ciliary motility (HP:0012262)	2.22887224
44	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.22698201
45	Unsteady gait (HP:0002317)	2.21266967
46	White forelock (HP:0002211)	2.19614560
47	Septo-optic dysplasia (HP:0100842)	2.18544894
48	Exertional dyspnea (HP:0002875)	2.17866640
49	Renal Fanconi syndrome (HP:0001994)	2.15707159
50	Absent thumb (HP:0009777)	2.15177586
51	Inability to walk (HP:0002540)	2.15062886
52	Abnormality of the renal collecting system (HP:0004742)	2.14901719
53	Retinal dysplasia (HP:0007973)	2.14743790
54	Abnormality of lateral ventricle (HP:0030047)	2.10244921
55	Optic disc pallor (HP:0000543)	2.09809786
56	Abnormal respiratory epithelium morphology (HP:0012253)	2.07943335
57	Abnormal respiratory motile cilium morphology (HP:0005938)	2.07943335
58	Clumsiness (HP:0002312)	2.07578980
59	Abdominal situs inversus (HP:0003363)	2.05777626
60	Abnormality of abdominal situs (HP:0011620)	2.05777626
61	Pancytopenia (HP:0001876)	2.04448714
62	Sensory axonal neuropathy (HP:0003390)	2.04132856
63	Rib fusion (HP:0000902)	2.03656228
64	Proximal amyotrophy (HP:0007126)	2.03305092
65	Male pseudohermaphroditism (HP:0000037)	2.02827060
66	Duodenal stenosis (HP:0100867)	1.99968729
67	Small intestinal stenosis (HP:0012848)	1.99968729
68	Abnormality of the columella (HP:0009929)	1.97746665
69	Self-mutilation (HP:0000742)	1.97525541
70	Benign neoplasm of the central nervous system (HP:0100835)	1.97203599
71	Type II lissencephaly (HP:0007260)	1.96012137
72	Triphalangeal thumb (HP:0001199)	1.94816588
73	Amyloidosis (HP:0011034)	1.92732747
74	Delayed CNS myelination (HP:0002188)	1.91687819
75	Dyschromatopsia (HP:0007641)	1.89782769
76	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.88504550
77	Pancreatic cysts (HP:0001737)	1.88472178
78	Patchy hypopigmentation of hair (HP:0011365)	1.88292770
79	Anencephaly (HP:0002323)	1.87850186
80	Rhinitis (HP:0012384)	1.86528575
81	Pallor (HP:0000980)	1.85037349
82	Median cleft lip (HP:0000161)	1.84996550
83	Hypoplasia of the pons (HP:0012110)	1.84698879
84	Abnormality of the pons (HP:0007361)	1.84067190
85	Abnormality of secondary sexual hair (HP:0009888)	1.84066219
86	Abnormality of the axillary hair (HP:0100134)	1.84066219
87	Hepatocellular necrosis (HP:0001404)	1.83940653
88	Supernumerary ribs (HP:0005815)	1.83541768
89	Abnormality of male internal genitalia (HP:0000022)	1.81881034
90	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.81217406
91	Pheochromocytoma (HP:0002666)	1.79951712
92	Neoplasm of the adrenal gland (HP:0100631)	1.79938482
93	Esophageal atresia (HP:0002032)	1.79024518
94	Abnormality of the duodenum (HP:0002246)	1.76646067
95	Chronic hepatic failure (HP:0100626)	1.76444567
96	Abnormality of the prostate (HP:0008775)	1.76442516
97	Neuroendocrine neoplasm (HP:0100634)	1.75230980
98	Chorioretinal atrophy (HP:0000533)	1.74718504
99	Abnormality of the preputium (HP:0100587)	1.74645364
100	Birth length less than 3rd percentile (HP:0003561)	1.73783476

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	5.37155113
2	TRIM28	4.06204275
3	WEE1	3.72042549
4	VRK2	3.55811378
5	MARK3	3.19229856
6	STK16	2.75427187
7	SIK3	2.73933913
8	TLK1	2.37715864
9	BMPR1B	2.35552918
10	DYRK3	2.29758257
11	WNK3	2.08236285
12	TGFBR1	2.03866192
13	NEK2	2.00633969
14	VRK1	1.93239422
15	DYRK2	1.88207474
16	TNIK	1.85759605
17	NUAK1	1.84464877
18	MUSK	1.74868837
19	OBSCN	1.69196093
20	ZAK	1.68072472
21	MAP2K7	1.68006626
22	MELK	1.67910530
23	GRK1	1.53305936
24	MAPK15	1.52099909
25	NLK	1.47489664
26	CSNK1A1L	1.40356270
27	CSNK1G3	1.31645808
28	PBK	1.29587764
29	EIF2AK3	1.29121239
30	GRK5	1.28562563
31	STK38L	1.27310933
32	SRPK1	1.24389124
33	PNCK	1.22473501
34	BCR	1.19420355
35	CDC7	1.17216698
36	MINK1	1.14915410
37	CSNK1G2	1.12444671
38	CDK3	1.09809014
39	ACVR1B	1.07723392
40	NEK1	1.00127168
41	MAPKAPK5	1.00030401
42	CDK8	0.94431253
43	KSR1	0.93112297
44	TAF1	0.93048702
45	CSNK1G1	0.86440124
46	NME1	0.82509228
47	MAP4K2	0.79828728
48	CASK	0.79243227
49	EIF2AK2	0.76355868
50	MAPK13	0.74231784
51	PAK3	0.70662452
52	TIE1	0.69925048
53	BRSK2	0.67125440
54	MYLK	0.66777810
55	ADRBK2	0.65647788
56	RPS6KA5	0.65402495
57	LRRK2	0.64900761
58	SGK223	0.64828856
59	SGK494	0.64828856
60	RPS6KA4	0.62396824
61	DAPK2	0.61231483
62	BUB1	0.57786665
63	WNK4	0.55616118
64	ADRBK1	0.53265862
65	PAK6	0.53099581
66	TYRO3	0.52112667
67	PDK2	0.51845539
68	PKN1	0.48537071
69	DAPK3	0.48272384
70	PLK1	0.47872871
71	MAP3K4	0.45576476
72	GRK6	0.45285109
73	SGK2	0.43452471
74	MOS	0.42800310
75	AURKB	0.42301676
76	LATS1	0.41451688
77	MARK1	0.39637465
78	TAOK3	0.38754877
79	PLK4	0.37752894
80	PRKCQ	0.36430256
81	BCKDK	0.35097281
82	PRKG1	0.34699226
83	LATS2	0.34253833
84	AKT3	0.33216930
85	CDK7	0.32861184
86	PASK	0.32524162
87	PLK3	0.32331813
88	CSNK1A1	0.31956163
89	KIT	0.31508332
90	DDR2	0.30839429
91	PAK1	0.30497140
92	STK11	0.30274809
93	NTRK2	0.29411089
94	GRK7	0.29044916
95	EPHB1	0.28960809
96	FLT3	0.28424489
97	RPS6KA1	0.27646480
98	TNK2	0.27553128
99	ATR	0.27132321
100	MKNK1	0.26648108

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.14102614
2	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	3.37635057
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.18416525
4	Phototransduction_Homo sapiens_hsa04744	2.94507882
5	Parkinsons disease_Homo sapiens_hsa05012	2.94077829
6	Olfactory transduction_Homo sapiens_hsa04740	2.56074196
7	Protein export_Homo sapiens_hsa03060	2.38415155
8	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.34886063
9	Butanoate metabolism_Homo sapiens_hsa00650	2.34128655
10	Proteasome_Homo sapiens_hsa03050	2.12215308
11	Fanconi anemia pathway_Homo sapiens_hsa03460	2.02287732
12	DNA replication_Homo sapiens_hsa03030	2.00224317
13	Basal cell carcinoma_Homo sapiens_hsa05217	1.94708565
14	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.87295425
15	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.84456113
16	Huntingtons disease_Homo sapiens_hsa05016	1.82738750
17	Homologous recombination_Homo sapiens_hsa03440	1.82629061
18	Alzheimers disease_Homo sapiens_hsa05010	1.80846786
19	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.80308754
20	RNA polymerase_Homo sapiens_hsa03020	1.79104357
21	Mismatch repair_Homo sapiens_hsa03430	1.73440508
22	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.65637840
23	Steroid biosynthesis_Homo sapiens_hsa00100	1.50322223
24	Nitrogen metabolism_Homo sapiens_hsa00910	1.44455270
25	One carbon pool by folate_Homo sapiens_hsa00670	1.44405075
26	Basal transcription factors_Homo sapiens_hsa03022	1.44191591
27	Nucleotide excision repair_Homo sapiens_hsa03420	1.44139165
28	RNA degradation_Homo sapiens_hsa03018	1.42357076
29	Cardiac muscle contraction_Homo sapiens_hsa04260	1.39844927
30	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.33091019
31	Chemical carcinogenesis_Homo sapiens_hsa05204	1.33033979
32	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.31681454
33	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.29653944
34	Propanoate metabolism_Homo sapiens_hsa00640	1.25854917
35	Linoleic acid metabolism_Homo sapiens_hsa00591	1.22746474
36	Folate biosynthesis_Homo sapiens_hsa00790	1.17074808
37	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.12064138
38	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.11508804
39	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.05097296
40	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.04857235
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.04799944
42	Glutathione metabolism_Homo sapiens_hsa00480	1.04720863
43	Peroxisome_Homo sapiens_hsa04146	1.01244526
44	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.99691636
45	Pyrimidine metabolism_Homo sapiens_hsa00240	0.98359739
46	Tyrosine metabolism_Homo sapiens_hsa00350	0.98327184
47	Phenylalanine metabolism_Homo sapiens_hsa00360	0.98033217
48	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.97175184
49	Non-homologous end-joining_Homo sapiens_hsa03450	0.94631082
50	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.89753723
51	Purine metabolism_Homo sapiens_hsa00230	0.89370535
52	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.88699083
53	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.85523058
54	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.84959184
55	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.84203848
56	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.82867698
57	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.80139699
58	Base excision repair_Homo sapiens_hsa03410	0.78852206
59	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.78322268
60	Spliceosome_Homo sapiens_hsa03040	0.77492507
61	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.75517385
62	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.75096759
63	Taste transduction_Homo sapiens_hsa04742	0.73363291
64	beta-Alanine metabolism_Homo sapiens_hsa00410	0.72726124
65	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.71479704
66	Fat digestion and absorption_Homo sapiens_hsa04975	0.70247900
67	Oocyte meiosis_Homo sapiens_hsa04114	0.64395892
68	Metabolic pathways_Homo sapiens_hsa01100	0.63499007
69	Wnt signaling pathway_Homo sapiens_hsa04310	0.61987025
70	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.61896095
71	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.60122149
72	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.57354281
73	Selenocompound metabolism_Homo sapiens_hsa00450	0.52655064
74	Melanogenesis_Homo sapiens_hsa04916	0.50890773
75	Hippo signaling pathway_Homo sapiens_hsa04390	0.49444958
76	Cell cycle_Homo sapiens_hsa04110	0.48462208
77	Sulfur relay system_Homo sapiens_hsa04122	0.46989409
78	Circadian entrainment_Homo sapiens_hsa04713	0.45053775
79	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.44574723
80	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.42024758
81	Calcium signaling pathway_Homo sapiens_hsa04020	0.40133094
82	Alcoholism_Homo sapiens_hsa05034	0.38791263
83	Axon guidance_Homo sapiens_hsa04360	0.38535668
84	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.38209380
85	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.38207080
86	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.38134533
87	Nicotine addiction_Homo sapiens_hsa05033	0.37869606
88	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.37472849
89	Circadian rhythm_Homo sapiens_hsa04710	0.32778144
90	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.31735559
91	Arginine biosynthesis_Homo sapiens_hsa00220	0.31121818
92	RNA transport_Homo sapiens_hsa03013	0.30277506
93	Tryptophan metabolism_Homo sapiens_hsa00380	0.29357301
94	Retinol metabolism_Homo sapiens_hsa00830	0.28568422
95	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.27152268
96	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.27008743
97	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.25582671
98	Caffeine metabolism_Homo sapiens_hsa00232	0.25235507
99	Gap junction_Homo sapiens_hsa04540	0.24430557
100	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.24228466

PFN1P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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