PFN1P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1eosinophil chemotaxis (GO:0048245)6.78387306
2coenzyme catabolic process (GO:0009109)6.44310307
3eosinophil migration (GO:0072677)5.96845167
4response to muscle activity (GO:0014850)5.48464687
5mRNA cleavage (GO:0006379)5.42469022
6positive regulation of protein kinase C signaling (GO:0090037)5.02773787
7positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)4.94612944
8cellular response to ethanol (GO:0071361)4.63415478
9cellular response to zinc ion (GO:0071294)4.51613513
10negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.43268354
11regulation of phospholipase A2 activity (GO:0032429)4.34170136
12facial nerve structural organization (GO:0021612)4.31218885
13ribosomal small subunit biogenesis (GO:0042274)4.30798757
14peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)4.25635522
15muscle cell cellular homeostasis (GO:0046716)4.22808419
16mannose metabolic process (GO:0006013)4.16151468
17membrane raft organization (GO:0031579)4.12524340
18activation of protein kinase B activity (GO:0032148)4.04412588
19regulation of ARF GTPase activity (GO:0032312)3.94648662
20negative regulation of defense response to virus (GO:0050687)3.80754288
21negative regulation of macroautophagy (GO:0016242)3.76561144
22positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.68345165
23AMP metabolic process (GO:0046033)3.61720827
24negative regulation of striated muscle cell apoptotic process (GO:0010664)3.60313576
25myoblast migration (GO:0051451)3.59633067
26COPII vesicle coating (GO:0048208)3.56821398
27positive regulation of catecholamine secretion (GO:0033605)3.56448597
28muscle cell migration (GO:0014812)3.55408119
29positive regulation of calcium ion transport into cytosol (GO:0010524)3.53209694
30mesenchymal-epithelial cell signaling (GO:0060638)3.49224666
31cofactor catabolic process (GO:0051187)3.33329514
32C21-steroid hormone biosynthetic process (GO:0006700)3.33234507
33negative regulation of cell size (GO:0045792)3.31581325
34actin filament depolymerization (GO:0030042)3.29905689
35tongue development (GO:0043586)3.25179144
36retina vasculature morphogenesis in camera-type eye (GO:0061299)3.24591168
37barbed-end actin filament capping (GO:0051016)3.21489610
38paraxial mesoderm development (GO:0048339)3.20129828
39L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.18189953
40fibroblast migration (GO:0010761)3.17969362
41positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.17567735
42cortical actin cytoskeleton organization (GO:0030866)3.14912806
43bone trabecula formation (GO:0060346)3.14610462
44regulation of autophagic vacuole assembly (GO:2000785)3.13125172
45regulation of acrosome reaction (GO:0060046)3.12435934
46regulation of lymphocyte chemotaxis (GO:1901623)3.08961439
47spermatid nucleus differentiation (GO:0007289)3.03929757
48chondroitin sulfate catabolic process (GO:0030207)3.03650230
49regulation of receptor binding (GO:1900120)3.03330824
50cranial nerve structural organization (GO:0021604)3.03016641
51regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.01915625
52xenobiotic catabolic process (GO:0042178)3.01075620
53cellular response to cadmium ion (GO:0071276)2.99414906
54L-methionine salvage (GO:0071267)2.98581516
55L-methionine biosynthetic process (GO:0071265)2.98581516
56amino acid salvage (GO:0043102)2.98581516
57establishment of mitotic spindle orientation (GO:0000132)2.98135974
58cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.97394521
59regulation of protein kinase C signaling (GO:0090036)2.95909846
60myofibril assembly (GO:0030239)2.95624076
61protein localization to cell surface (GO:0034394)2.90493156
62regulation of myoblast differentiation (GO:0045661)2.89136444
63cellular response to interferon-alpha (GO:0035457)2.88771812
64negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.88392368
65diacylglycerol metabolic process (GO:0046339)2.86767297
66regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.83343646
67T cell migration (GO:0072678)2.82723572
68positive regulation of lymphocyte migration (GO:2000403)2.81306520
69regulation of phosphoprotein phosphatase activity (GO:0043666)2.81201756
70TOR signaling (GO:0031929)2.81140422
71DNA double-strand break processing (GO:0000729)2.80943323
72regulation of cell size (GO:0008361)2.77560787
73negative regulation of stem cell proliferation (GO:2000647)2.77478648
74focal adhesion assembly (GO:0048041)2.73788916
75cell-substrate adherens junction assembly (GO:0007045)2.73788916
76membrane tubulation (GO:0097320)2.72731151
77regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.71670381
78negative regulation of organelle assembly (GO:1902116)2.71024218
79establishment of mitotic spindle localization (GO:0040001)2.70754356
80cortical cytoskeleton organization (GO:0030865)2.66792918
81oligosaccharide biosynthetic process (GO:0009312)2.66729460
82radial glial cell differentiation (GO:0060019)2.66226252
83regulation of oxidative phosphorylation (GO:0002082)2.66148992
84ADP metabolic process (GO:0046031)2.64717814
85regulation of apoptotic process involved in morphogenesis (GO:1902337)2.64526195
86muscle fiber development (GO:0048747)2.63546712
87negative regulation of response to reactive oxygen species (GO:1901032)2.63019373
88neuron projection extension involved in neuron projection guidance (GO:1902284)2.61637600
89axon extension involved in axon guidance (GO:0048846)2.61637600
90negative regulation of necroptotic process (GO:0060546)2.61547326
91regulation of apoptotic cell clearance (GO:2000425)2.58091104
92multicellular organism reproduction (GO:0032504)2.56368756
93regulation of macrophage chemotaxis (GO:0010758)2.55677941
94regulation of hydrogen peroxide-induced cell death (GO:1903205)2.54467708
95regulation of oxidative stress-induced neuron death (GO:1903203)2.53109162
96establishment of spindle orientation (GO:0051294)2.51517971
97C21-steroid hormone metabolic process (GO:0008207)2.49348925
98nucleoside diphosphate biosynthetic process (GO:0009133)2.48621165
99cellular zinc ion homeostasis (GO:0006882)2.48580555
100heterochromatin organization (GO:0070828)2.48064970

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.36536064
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.27602720
3ESR1_20079471_ChIP-ChIP_T-47D_Human4.26757283
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.24865600
5ESR1_15608294_ChIP-ChIP_MCF-7_Human3.08530669
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.81212452
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.78571209
8CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.49387864
9AR_21572438_ChIP-Seq_LNCaP_Human2.44145833
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.22739490
11GATA1_22025678_ChIP-Seq_K562_Human2.22223902
12GBX2_23144817_ChIP-Seq_PC3_Human2.05124833
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.04629556
14CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.91864571
15ELK3_25401928_ChIP-Seq_HUVEC_Human1.90948672
16STAT6_21828071_ChIP-Seq_BEAS2B_Human1.89132102
17TP53_22127205_ChIP-Seq_IMR90_Human1.78633756
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.75435205
19MAF_26560356_Chip-Seq_TH2_Human1.74004328
20TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.62594238
21KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.60885464
22FOXM1_23109430_ChIP-Seq_U2OS_Human1.57328216
23KDM2B_26808549_Chip-Seq_DND41_Human1.56591090
24TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55660724
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55047389
26LXR_22292898_ChIP-Seq_THP-1_Human1.54978328
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.53536800
28RACK7_27058665_Chip-Seq_MCF-7_Human1.52625958
29ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.51847954
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.49581272
31ZNF263_19887448_ChIP-Seq_K562_Human1.48211671
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.48153473
33ELF1_20517297_ChIP-Seq_JURKAT_Human1.47837121
34BRD4_25478319_ChIP-Seq_HGPS_Human1.45346708
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.44107216
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.39865130
37PPAR_26484153_Chip-Seq_NCI-H1993_Human1.39704535
38CJUN_26792858_Chip-Seq_BT549_Human1.35320353
39SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33691804
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.32702922
41SMC4_20622854_ChIP-Seq_HELA_Human1.32129266
42CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31171574
43MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.29507905
44CTCF_21964334_Chip-Seq_Bcells_Human1.29268756
45TBX20_22080862_ChIP-Seq_HEART_Mouse1.29116235
46TBX20_22328084_ChIP-Seq_HEART_Mouse1.29116235
47ATF3_27146783_Chip-Seq_COLON_Human1.26038776
48MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.25981391
49ERA_21632823_ChIP-Seq_H3396_Human1.23506846
50WDR5_24793694_ChIP-Seq_LNCAP_Human1.23477138
51SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.23466319
52SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.23466319
53DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21752406
54RAD21_21589869_ChIP-Seq_MESCs_Mouse1.21561754
55UBF1/2_26484160_Chip-Seq_HMECs_Human1.21406571
56VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.21245069
57RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21173956
58GATA2_21666600_ChIP-Seq_HMVEC_Human1.21169588
59WT1_19549856_ChIP-ChIP_CCG9911_Human1.19730436
60RAC3_21632823_ChIP-Seq_H3396_Human1.19156097
61TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19048318
62CTCF_21964334_ChIP-Seq_BJAB-B_Human1.16096868
63TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.16087023
64ER_23166858_ChIP-Seq_MCF-7_Human1.16017205
65HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.14100868
66CIITA_25753668_ChIP-Seq_RAJI_Human1.14043262
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.13663238
68JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.13082741
69HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12429911
70NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.11319436
71UTX_26944678_Chip-Seq_JUKART_Human1.10503720
72CSB_26484114_Chip-Seq_FIBROBLAST_Human1.09025500
73VDR_21846776_ChIP-Seq_THP-1_Human1.08447889
74SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07889352
75THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06816896
76IGF1R_20145208_ChIP-Seq_DFB_Human1.05936126
77KDM2B_26808549_Chip-Seq_JURKAT_Human1.03747209
78RXR_22108803_ChIP-Seq_LS180_Human1.02439832
79SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02126815
80NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02012063
81RUNX1_27514584_Chip-Seq_MCF-7_Human1.00217515
82ELF5_23300383_ChIP-Seq_T47D_Human0.99942435
83TP53_23651856_ChIP-Seq_MEFs_Mouse0.99387303
84STAT1_20625510_ChIP-Seq_HELA_Human0.98743272
85KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98336878
86TET1_21451524_ChIP-Seq_MESCs_Mouse0.97540611
87SPI1_20517297_ChIP-Seq_HL60_Human0.97195694
88JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97172336
89MAF_26560356_Chip-Seq_TH1_Human0.96792990
90TP63_22573176_ChIP-Seq_HFKS_Human0.95510594
91TBX5_21415370_ChIP-Seq_HL-1_Mouse0.95123205
92TP53_18474530_ChIP-ChIP_U2OS_Human0.95042866
93PHF8_20622854_ChIP-Seq_HELA_Human0.94727921
94EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93609967
95RARA_24833708_ChIP-Seq_LIVER_Mouse0.92971025
96CHD1_26751641_Chip-Seq_LNCaP_Human0.92911244
97ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91656061
98TP53_20018659_ChIP-ChIP_R1E_Mouse0.90648176
99CTCF_27219007_Chip-Seq_ERYTHROID_Human0.90526008
100GATA6_25053715_ChIP-Seq_YYC3_Human0.90494776

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000749_muscle_degeneration4.15562670
2MP0003950_abnormal_plasma_membrane4.03355576
3MP0004084_abnormal_cardiac_muscle3.78179151
4MP0003806_abnormal_nucleotide_metabolis3.58030306
5MP0000537_abnormal_urethra_morphology3.48409124
6MP0010368_abnormal_lymphatic_system3.41422016
7MP0004272_abnormal_basement_membrane3.13456169
8MP0009780_abnormal_chondrocyte_physiolo2.99316986
9MP0005360_urolithiasis2.95926656
10MP0009840_abnormal_foam_cell2.58653960
11MP0005058_abnormal_lysosome_morphology2.51664959
12MP0003315_abnormal_perineum_morphology2.51037073
13MP0003172_abnormal_lysosome_physiology2.48166167
14MP0004036_abnormal_muscle_relaxation2.41062096
15MP0010030_abnormal_orbit_morphology2.39073087
16MP0001986_abnormal_taste_sensitivity2.33313142
17MP0001849_ear_inflammation2.24899762
18MP0004381_abnormal_hair_follicle2.14205910
19MP0008438_abnormal_cutaneous_collagen2.07483073
20MP0002132_abnormal_respiratory_system2.06901578
21MP0003191_abnormal_cellular_cholesterol2.03114877
22MP0001661_extended_life_span1.96826829
23MP0002108_abnormal_muscle_morphology1.83728429
24MP0003091_abnormal_cell_migration1.72187823
25MP0003763_abnormal_thymus_physiology1.66650574
26MP0001270_distended_abdomen1.66088344
27MP0009697_abnormal_copulation1.60045057
28MP0000751_myopathy1.54890437
29MP0005330_cardiomyopathy1.54649785
30MP0003705_abnormal_hypodermis_morpholog1.54385567
31MP0002269_muscular_atrophy1.52104991
32MP0009384_cardiac_valve_regurgitation1.47258376
33MP0002837_dystrophic_cardiac_calcinosis1.46697697
34MP0000759_abnormal_skeletal_muscle1.40324042
35MP0002127_abnormal_cardiovascular_syste1.32761168
36MP0000733_abnormal_muscle_development1.31814577
37MP0000462_abnormal_digestive_system1.31072098
38MP0006138_congestive_heart_failure1.30895987
39MP0009250_abnormal_appendicular_skeleto1.30653142
40MP0000750_abnormal_muscle_regeneration1.30002165
41MP0004087_abnormal_muscle_fiber1.26866416
42MP0005623_abnormal_meninges_morphology1.23094297
43MP0003279_aneurysm1.22653667
44MP0000767_abnormal_smooth_muscle1.21076781
45MP0005451_abnormal_body_composition1.20767187
46MP0006072_abnormal_retinal_apoptosis1.13716193
47MP0004233_abnormal_muscle_weight1.13411202
48MP0003385_abnormal_body_wall1.08520373
49MP0010234_abnormal_vibrissa_follicle1.08417755
50MP0005248_abnormal_Harderian_gland1.07692376
51MP0008004_abnormal_stomach_pH1.05963165
52MP0005503_abnormal_tendon_morphology1.05425486
53MP0008775_abnormal_heart_ventricle1.03524910
54MP0002282_abnormal_trachea_morphology1.00650217
55MP0002160_abnormal_reproductive_system0.99172720
56MP0003566_abnormal_cell_adhesion0.97432134
57MP0000762_abnormal_tongue_morphology0.96495229
58MP0001835_abnormal_antigen_presentation0.95933983
59MP0002932_abnormal_joint_morphology0.92865561
60MP0005394_taste/olfaction_phenotype0.92113511
61MP0005499_abnormal_olfactory_system0.92113511
62MP0005164_abnormal_response_to0.91832297
63MP0003136_yellow_coat_color0.87696606
64MP0002233_abnormal_nose_morphology0.87250491
65MP0002295_abnormal_pulmonary_circulatio0.85998198
66MP0004484_altered_response_of0.83970202
67MP0000685_abnormal_immune_system0.82440763
68MP0005620_abnormal_muscle_contractility0.82286115
69MP0005595_abnormal_vascular_smooth0.80878732
70MP0010630_abnormal_cardiac_muscle0.80217224
71MP0001348_abnormal_lacrimal_gland0.79988658
72MP0001873_stomach_inflammation0.79966801
73MP0004883_abnormal_blood_vessel0.79252403
74MP0003868_abnormal_feces_composition0.77590850
75MP0003828_pulmonary_edema0.76020416
76MP0001299_abnormal_eye_distance/0.73997888
77MP0001544_abnormal_cardiovascular_syste0.73669677
78MP0005385_cardiovascular_system_phenoty0.73669677
79MP0002115_abnormal_skeleton_extremities0.72656196
80MP0002249_abnormal_larynx_morphology0.71909945
81MP0004134_abnormal_chest_morphology0.71276269
82MP0001879_abnormal_lymphatic_vessel0.69565022
83MP0004510_myositis0.69145995
84MP0005023_abnormal_wound_healing0.68616998
85MP0002139_abnormal_hepatobiliary_system0.68523242
86MP0000538_abnormal_urinary_bladder0.65365374
87MP0002098_abnormal_vibrissa_morphology0.64356984
88MP0002128_abnormal_blood_circulation0.63682195
89MP0000015_abnormal_ear_pigmentation0.61736432
90MP0001340_abnormal_eyelid_morphology0.60869461
91MP0010386_abnormal_urinary_bladder0.59704754
92MP0003935_abnormal_craniofacial_develop0.59626964
93MP0002138_abnormal_hepatobiliary_system0.58710763
94MP0002092_abnormal_eye_morphology0.58454330
95MP0000163_abnormal_cartilage_morphology0.58411304
96MP0002116_abnormal_craniofacial_bone0.58125030
97MP0008875_abnormal_xenobiotic_pharmacok0.57982300
98MP0000681_abnormal_thyroid_gland0.57798257
99MP0002972_abnormal_cardiac_muscle0.57358412
100MP0008789_abnormal_olfactory_epithelium0.56340576

Predicted human phenotypes

RankGene SetZ-score
1Spinal rigidity (HP:0003306)4.22537930
2Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)4.16548851
3Aortic aneurysm (HP:0004942)4.10255108
4Scapular winging (HP:0003691)4.07120267
5Aortic regurgitation (HP:0001659)3.93582639
6Thoracic kyphosis (HP:0002942)3.92874704
7Hyporeflexia of lower limbs (HP:0002600)3.65589748
8Abnormality of the thoracic spine (HP:0100711)3.43726885
9Pustule (HP:0200039)3.43518867
10Protrusio acetabuli (HP:0003179)3.43481973
11Abnormality of the shoulder girdle musculature (HP:0001435)3.42338032
12Aplasia/Hypoplasia involving the sinuses (HP:0009120)3.37196740
13Exercise-induced myalgia (HP:0003738)3.37193073
14Reduced antithrombin III activity (HP:0001976)3.35455720
15Abnormality of the columella (HP:0009929)3.27830108
16J-shaped sella turcica (HP:0002680)3.27800544
17Abnormality of the frontal sinuses (HP:0002687)3.27457666
18Centrally nucleated skeletal muscle fibers (HP:0003687)3.23487683
19Eosinophilia (HP:0001880)3.13835633
20Popliteal pterygium (HP:0009756)3.11857851
21Clumsiness (HP:0002312)3.10852756
22Sensory axonal neuropathy (HP:0003390)3.08133344
23Easy fatigability (HP:0003388)3.04910805
24High anterior hairline (HP:0009890)2.94139466
25Aortic dissection (HP:0002647)2.90902576
26Spinal cord lesions (HP:0100561)2.88526284
27Syringomyelia (HP:0003396)2.88526284
28Premature rupture of membranes (HP:0001788)2.79904519
29Abnormality of the lumbar spine (HP:0100712)2.77856079
30Papilledema (HP:0001085)2.75416998
31Granulocytopenia (HP:0001913)2.64927872
32Abnormality of the calf musculature (HP:0001430)2.58209806
33Resting tremor (HP:0002322)2.54493285
34Absent rod-and cone-mediated responses on ERG (HP:0007688)2.53742175
35Thoracolumbar scoliosis (HP:0002944)2.50198973
36Proximal amyotrophy (HP:0007126)2.46631205
37High pitched voice (HP:0001620)2.45965775
38Weak cry (HP:0001612)2.45797523
39Abnormality of eosinophils (HP:0001879)2.45792249
40Muscular dystrophy (HP:0003560)2.40919298
41Abnormality of the alveolar ridges (HP:0006477)2.38209563
42Ulnar bowing (HP:0003031)2.37126652
43Broad alveolar ridges (HP:0000187)2.34031443
44Mucopolysacchariduria (HP:0008155)2.31386413
45Urinary glycosaminoglycan excretion (HP:0003541)2.31386413
46Generalized amyotrophy (HP:0003700)2.30997730
47Cerebellar dysplasia (HP:0007033)2.28921854
48Increased variability in muscle fiber diameter (HP:0003557)2.25454606
49Abnormality of mucopolysaccharide metabolism (HP:0011020)2.23283664
50Abnormality of polysaccharide metabolism (HP:0011012)2.23283664
51Abnormality of glycosaminoglycan metabolism (HP:0004371)2.23283664
52Self-mutilation (HP:0000742)2.19332226
53Pterygium (HP:0001059)2.17772169
54Facial hemangioma (HP:0000329)2.16602888
55EMG: myopathic abnormalities (HP:0003458)2.12615927
56Bulbar palsy (HP:0001283)2.05690008
57Aplasia involving bones of the extremities (HP:0009825)2.05186574
58Aplasia involving bones of the upper limbs (HP:0009823)2.05186574
59Aplasia of the phalanges of the hand (HP:0009802)2.05186574
60Thick nail (HP:0001805)2.04965467
61Cervical subluxation (HP:0003308)2.03671296
62Muscle fiber atrophy (HP:0100295)2.03321874
63Vertebral arch anomaly (HP:0008438)2.01668720
64Turricephaly (HP:0000262)2.01085854
65Type 2 muscle fiber atrophy (HP:0003554)1.97556510
66Hypoventilation (HP:0002791)1.96537058
67Capillary hemangiomas (HP:0005306)1.96005535
68Xerostomia (HP:0000217)1.95678642
69Elbow flexion contracture (HP:0002987)1.95141998
70Abnormality of DNA repair (HP:0003254)1.95105775
71Fatigable weakness (HP:0003473)1.94714159
72Abnormality of the neuromuscular junction (HP:0003398)1.94714159
73Recurrent corneal erosions (HP:0000495)1.94542203
74Arterial tortuosity (HP:0005116)1.93590467
75Abnormality of the intrinsic pathway (HP:0010989)1.93018317
76Steppage gait (HP:0003376)1.92937461
77Renal cortical cysts (HP:0000803)1.90810908
78Male infertility (HP:0003251)1.84482392
79Bell-shaped thorax (HP:0001591)1.84481697
80Thin ribs (HP:0000883)1.84429320
81Spondylolisthesis (HP:0003302)1.83512717
82Dysostosis multiplex (HP:0000943)1.83410787
83Shallow orbits (HP:0000586)1.82358383
84Joint stiffness (HP:0001387)1.81248516
85Aneurysm (HP:0002617)1.79921469
86Abnormality of the anterior chamber (HP:0000593)1.78206522
87Cerebral aneurysm (HP:0004944)1.77766779
88Vascular tortuosity (HP:0004948)1.76671711
89Short palpebral fissure (HP:0012745)1.75141498
90Nonprogressive disorder (HP:0003680)1.73933370
91Wide nose (HP:0000445)1.72165160
92Abnormality of the incisor (HP:0000676)1.72079496
93Abnormality of skeletal muscle fiber size (HP:0012084)1.68753792
94Type II lissencephaly (HP:0007260)1.68691117
95Foot dorsiflexor weakness (HP:0009027)1.68648662
96Myoglobinuria (HP:0002913)1.66118570
97Abnormality of the acetabulum (HP:0003170)1.65350205
98Wide intermamillary distance (HP:0006610)1.64600094
99Rhabdomyolysis (HP:0003201)1.63444978
100Anterior segment dysgenesis (HP:0007700)1.62891768

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK15.69315197
2LATS15.26978984
3MUSK4.25636453
4BLK3.23239556
5MARK33.18298849
6SCYL23.11469641
7MYLK2.58940230
8LATS22.56693594
9NEK22.52148520
10OBSCN2.23756647
11STK38L2.13934720
12ICK1.95938811
13MAP3K101.86922138
14NME21.81929335
15MELK1.79712271
16MAP3K131.74005376
17PDGFRA1.64403739
18STK381.64101781
19TRIB31.61056064
20EEF2K1.60070591
21MST1R1.50052581
22MAPKAPK31.48052625
23PDK21.45401801
24MOS1.39684266
25EPHB21.34671396
26MET1.25404199
27FLT31.20576211
28CDK81.16615304
29GRK61.16146992
30SMG11.09307833
31MAP3K91.08107299
32MAP2K71.00918392
33SIK11.00281241
34ZAP700.99346394
35JAK10.96155009
36PRKG20.93728261
37CAMKK20.91339338
38CSNK1A1L0.91012617
39NTRK10.90773960
40CDK30.87413811
41NEK90.86195899
42MAPK120.85416111
43MAP3K10.83202251
44PRKD20.83097692
45MAP2K30.81263071
46PKN20.80479913
47SGK4940.79282885
48SGK2230.79282885
49BTK0.78636665
50TLK10.78341087
51MTOR0.76389000
52CDK120.75179336
53TTN0.75020872
54FGFR20.71807483
55PDPK10.71668742
56TRPM70.67380039
57RPS6KA40.67167319
58RPS6KB10.66178764
59NLK0.65694455
60ERN10.65076030
61PRKD30.63778176
62FGFR40.63175414
63MAP3K70.63174955
64TYK20.62544565
65CDC42BPA0.59996660
66PAK40.56690079
67MAP2K60.54979979
68PDGFRB0.54968326
69TIE10.54529165
70SGK20.51980222
71CCNB10.49425768
72PAK20.46635079
73MAPK110.45174451
74PRKCQ0.45075419
75DYRK30.43682221
76TGFBR10.42863247
77DAPK30.41059374
78PTK20.40824546
79MAPKAPK50.40603190
80EGFR0.40393689
81SGK30.37544323
82PTK2B0.35463346
83BMPR1B0.35103245
84AURKB0.34880402
85ROCK10.33984586
86SRPK10.33408386
87CSNK1G30.32920786
88CDK90.31326530
89EIF2AK30.31089968
90STK30.30887968
91EPHB10.30822643
92HIPK20.30508357
93PAK10.29418721
94AKT20.28818858
95AKT30.28524448
96MAP3K30.27065354
97EPHA20.26779060
98FGR0.26567499
99BRSK10.26328731
100TGFBR20.25760576

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005313.48164325
2Other glycan degradation_Homo sapiens_hsa005112.68542944
3Olfactory transduction_Homo sapiens_hsa047402.38875179
4Staphylococcus aureus infection_Homo sapiens_hsa051502.31983325
5Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.24272734
6Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.23920791
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.88808933
8ABC transporters_Homo sapiens_hsa020101.81658600
9Chemical carcinogenesis_Homo sapiens_hsa052041.78097553
10ECM-receptor interaction_Homo sapiens_hsa045121.73120552
11Focal adhesion_Homo sapiens_hsa045101.61630731
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.56725169
13Nitrogen metabolism_Homo sapiens_hsa009101.53738725
14Complement and coagulation cascades_Homo sapiens_hsa046101.50401827
15Drug metabolism - other enzymes_Homo sapiens_hsa009831.47104358
16Dilated cardiomyopathy_Homo sapiens_hsa054141.43635270
17cGMP-PKG signaling pathway_Homo sapiens_hsa040221.41123072
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.34419717
19Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.30682878
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.30462378
21Hedgehog signaling pathway_Homo sapiens_hsa043401.23167550
22Small cell lung cancer_Homo sapiens_hsa052221.22331239
23Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.19343695
24Arginine biosynthesis_Homo sapiens_hsa002201.18736750
25Viral myocarditis_Homo sapiens_hsa054161.15583974
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.14249477
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.14026564
28T cell receptor signaling pathway_Homo sapiens_hsa046601.13153399
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.12830710
30Prostate cancer_Homo sapiens_hsa052151.11444239
31Sphingolipid metabolism_Homo sapiens_hsa006001.11214383
32Vascular smooth muscle contraction_Homo sapiens_hsa042701.09961210
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.09616611
34N-Glycan biosynthesis_Homo sapiens_hsa005101.09248683
35Allograft rejection_Homo sapiens_hsa053301.07968739
36Thyroid cancer_Homo sapiens_hsa052161.07429428
37Autoimmune thyroid disease_Homo sapiens_hsa053201.06111456
38Renin secretion_Homo sapiens_hsa049241.05706229
39AMPK signaling pathway_Homo sapiens_hsa041521.01279834
40Malaria_Homo sapiens_hsa051440.99762585
41Oxytocin signaling pathway_Homo sapiens_hsa049210.99463123
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97475975
43Circadian rhythm_Homo sapiens_hsa047100.97203207
44Endometrial cancer_Homo sapiens_hsa052130.95540138
45Melanogenesis_Homo sapiens_hsa049160.92145287
46Sphingolipid signaling pathway_Homo sapiens_hsa040710.88345729
47PI3K-Akt signaling pathway_Homo sapiens_hsa041510.87577534
48FoxO signaling pathway_Homo sapiens_hsa040680.85337196
49B cell receptor signaling pathway_Homo sapiens_hsa046620.85199893
50Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85175666
51Choline metabolism in cancer_Homo sapiens_hsa052310.84800623
52Fanconi anemia pathway_Homo sapiens_hsa034600.84092944
53Selenocompound metabolism_Homo sapiens_hsa004500.82885841
54Hippo signaling pathway_Homo sapiens_hsa043900.82031078
55Non-small cell lung cancer_Homo sapiens_hsa052230.80882480
56VEGF signaling pathway_Homo sapiens_hsa043700.80046850
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79056961
58Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78982424
59Hepatitis B_Homo sapiens_hsa051610.78415989
60Phagosome_Homo sapiens_hsa041450.78314110
61Basal cell carcinoma_Homo sapiens_hsa052170.77631574
62Measles_Homo sapiens_hsa051620.76467412
63Non-homologous end-joining_Homo sapiens_hsa034500.74022398
64Apoptosis_Homo sapiens_hsa042100.73927349
65Ovarian steroidogenesis_Homo sapiens_hsa049130.73395460
66Proteoglycans in cancer_Homo sapiens_hsa052050.72440973
67Glucagon signaling pathway_Homo sapiens_hsa049220.71134412
68Phototransduction_Homo sapiens_hsa047440.70934482
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.67260434
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66259242
71p53 signaling pathway_Homo sapiens_hsa041150.66068505
72Lysosome_Homo sapiens_hsa041420.65383126
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65291238
74mTOR signaling pathway_Homo sapiens_hsa041500.65009713
75Primary immunodeficiency_Homo sapiens_hsa053400.62938843
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62793859
77Wnt signaling pathway_Homo sapiens_hsa043100.62602333
78Glioma_Homo sapiens_hsa052140.61951748
79Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61190020
80HTLV-I infection_Homo sapiens_hsa051660.61178632
81Toxoplasmosis_Homo sapiens_hsa051450.60496951
82Graft-versus-host disease_Homo sapiens_hsa053320.60054338
83Estrogen signaling pathway_Homo sapiens_hsa049150.59852439
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59539912
85GnRH signaling pathway_Homo sapiens_hsa049120.58909811
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56089251
87Ribosome_Homo sapiens_hsa030100.55496405
88Calcium signaling pathway_Homo sapiens_hsa040200.55303439
89Influenza A_Homo sapiens_hsa051640.52511713
90Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52370868
91Notch signaling pathway_Homo sapiens_hsa043300.51883289
92Platelet activation_Homo sapiens_hsa046110.51427231
93Chemokine signaling pathway_Homo sapiens_hsa040620.50102827
94Lysine degradation_Homo sapiens_hsa003100.49534263
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49240392
96Insulin signaling pathway_Homo sapiens_hsa049100.49151476
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48152118
98Melanoma_Homo sapiens_hsa052180.47680786
99TGF-beta signaling pathway_Homo sapiens_hsa043500.47516247
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45367080

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