PFN1P8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of phosphoprotein phosphatase activity (GO:0032516)6.45789667
2succinate metabolic process (GO:0006105)5.71274315
3negative regulation of mast cell activation (GO:0033004)5.33878256
4male sex determination (GO:0030238)5.07486294
5peptidyl-arginine omega-N-methylation (GO:0035247)4.96380520
6positive regulation of mitochondrial fission (GO:0090141)4.82143227
7positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)4.63359509
8regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)4.63359509
9positive regulation of B cell differentiation (GO:0045579)4.54469554
10DNA integration (GO:0015074)4.27077648
11negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)4.27055297
12peptidyl-arginine methylation (GO:0018216)4.20984392
13peptidyl-arginine N-methylation (GO:0035246)4.20984392
14regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)4.15779882
15positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO4.15779882
16peptidyl-histidine modification (GO:0018202)4.06729557
17piRNA metabolic process (GO:0034587)4.05054669
18fibroblast migration (GO:0010761)3.98583695
19tricarboxylic acid cycle (GO:0006099)3.92410921
20S-adenosylmethionine metabolic process (GO:0046500)3.90500621
21regulation of mitochondrial fission (GO:0090140)3.89131487
22negative regulation of phagocytosis (GO:0050765)3.71883273
23cytoplasmic mRNA processing body assembly (GO:0033962)3.71474504
24RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.70311180
25histone arginine methylation (GO:0034969)3.65628008
26regulation of activation of Janus kinase activity (GO:0010533)3.63808849
27glycosphingolipid biosynthetic process (GO:0006688)3.62145144
28exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.54429395
29coenzyme catabolic process (GO:0009109)3.53017557
30nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.51485488
31sulfation (GO:0051923)3.50865008
32ganglioside metabolic process (GO:0001573)3.49551886
33male meiosis (GO:0007140)3.42308735
34replication fork processing (GO:0031297)3.40888134
35monoubiquitinated protein deubiquitination (GO:0035520)3.40557111
36lung-associated mesenchyme development (GO:0060484)3.40527340
37positive regulation of mRNA catabolic process (GO:0061014)3.37874735
38positive regulation of mRNA 3-end processing (GO:0031442)3.30307251
39positive regulation of fatty acid oxidation (GO:0046321)3.27460294
40amino acid salvage (GO:0043102)3.24823924
41L-methionine salvage (GO:0071267)3.24823924
42L-methionine biosynthetic process (GO:0071265)3.24823924
43negative regulation of activin receptor signaling pathway (GO:0032926)3.22432700
44resolution of meiotic recombination intermediates (GO:0000712)3.22147923
45reciprocal meiotic recombination (GO:0007131)3.18398399
46reciprocal DNA recombination (GO:0035825)3.18398399
47maturation of 5.8S rRNA (GO:0000460)3.14597358
48regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)3.14572377
49regulation of mRNA catabolic process (GO:0061013)3.13817843
50negative regulation of systemic arterial blood pressure (GO:0003085)3.12994193
51spermatid development (GO:0007286)3.12470623
52somite rostral/caudal axis specification (GO:0032525)3.12239447
53DNA methylation involved in gamete generation (GO:0043046)3.11913114
54base-excision repair, AP site formation (GO:0006285)3.09106494
55regulation of phosphoprotein phosphatase activity (GO:0043666)3.08568065
56histone mRNA catabolic process (GO:0071044)3.08301605
57spermatid nucleus differentiation (GO:0007289)3.07836127
58organelle disassembly (GO:1903008)3.07063324
59regulation of mitochondrial depolarization (GO:0051900)3.03394480
60methionine biosynthetic process (GO:0009086)2.99326986
61positive regulation of growth hormone secretion (GO:0060124)2.97625859
62pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.97007105
63L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.94014616
64methionine metabolic process (GO:0006555)2.93695496
65behavioral response to nicotine (GO:0035095)2.86381179
66galactose catabolic process (GO:0019388)2.83205392
67meiosis I (GO:0007127)2.82856591
68photoreceptor cell development (GO:0042461)2.81501301
69positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.80775610
70urinary tract smooth muscle contraction (GO:0014848)2.80399336
71negative regulation of organelle assembly (GO:1902116)2.80132007
72adaptation of signaling pathway (GO:0023058)2.79454749
73regulation of mRNA 3-end processing (GO:0031440)2.78271406
74mannosylation (GO:0097502)2.77033290
75epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.74483014
76sulfur amino acid biosynthetic process (GO:0000097)2.74052600
77protein K63-linked deubiquitination (GO:0070536)2.73521355
78mitotic cell cycle arrest (GO:0071850)2.72245122
79tryptophan catabolic process (GO:0006569)2.71909776
80indole-containing compound catabolic process (GO:0042436)2.71909776
81indolalkylamine catabolic process (GO:0046218)2.71909776
82establishment of nucleus localization (GO:0040023)2.70945255
83negative regulation of cell cycle arrest (GO:0071157)2.70672341
84response to redox state (GO:0051775)2.70304399
85protein localization to synapse (GO:0035418)2.70182557
86serine family amino acid catabolic process (GO:0009071)2.69561689
87mRNA cleavage (GO:0006379)2.69120681
88pyrimidine nucleotide catabolic process (GO:0006244)2.63544599
89gene silencing by RNA (GO:0031047)2.60531959
90proteasome assembly (GO:0043248)2.59700567
91sex determination (GO:0007530)2.58322881
92retinal cone cell development (GO:0046549)2.57740388
93protein K6-linked ubiquitination (GO:0085020)2.57315008
94eye photoreceptor cell development (GO:0042462)2.54521300
95positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.54491493
96mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.54491493
97regulation of hexokinase activity (GO:1903299)2.51865101
98regulation of glucokinase activity (GO:0033131)2.51865101
99pyrimidine nucleobase catabolic process (GO:0006208)2.51434784
100double-strand break repair via homologous recombination (GO:0000724)2.48815220

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.39663848
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.78621291
3EZH2_22144423_ChIP-Seq_EOC_Human3.77656543
4ZNF274_21170338_ChIP-Seq_K562_Hela3.71355571
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.58960889
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.56163357
7VDR_22108803_ChIP-Seq_LS180_Human3.39148067
8IGF1R_20145208_ChIP-Seq_DFB_Human3.37005249
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.81726547
10ESR1_15608294_ChIP-ChIP_MCF-7_Human2.76282719
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.58941678
12GBX2_23144817_ChIP-Seq_PC3_Human2.46210484
13CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.43878174
14IRF1_19129219_ChIP-ChIP_H3396_Human2.33535639
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.27589427
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17308067
17EGR1_23403033_ChIP-Seq_LIVER_Mouse1.98904923
18ER_23166858_ChIP-Seq_MCF-7_Human1.92352278
19TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89825076
20POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.89825076
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86217533
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83505496
23P300_19829295_ChIP-Seq_ESCs_Human1.83497230
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79373704
25IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.76750394
26CBP_20019798_ChIP-Seq_JUKART_Human1.76750394
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.64922967
28SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.57178220
29ESR1_20079471_ChIP-ChIP_T-47D_Human1.53380167
30BCAT_22108803_ChIP-Seq_LS180_Human1.51585200
31EWS_26573619_Chip-Seq_HEK293_Human1.49160812
32CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.47732667
33AR_21572438_ChIP-Seq_LNCaP_Human1.47143990
34ETV2_25802403_ChIP-Seq_MESCs_Mouse1.46594774
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.46036884
36GABP_17652178_ChIP-ChIP_JURKAT_Human1.41786589
37FUS_26573619_Chip-Seq_HEK293_Human1.41228383
38KLF5_20875108_ChIP-Seq_MESCs_Mouse1.39604964
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35775467
40CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30297563
41ELK1_19687146_ChIP-ChIP_HELA_Human1.30286484
42WDR5_24793694_ChIP-Seq_LNCAP_Human1.29117180
43MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28837130
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27810910
45TCF4_23295773_ChIP-Seq_U87_Human1.26551810
46TCF4_22108803_ChIP-Seq_LS180_Human1.25696600
47PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24592721
48AUTS2_25519132_ChIP-Seq_293T-REX_Human1.22525302
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20427098
50PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.20325564
51VDR_23849224_ChIP-Seq_CD4+_Human1.19991639
52ERA_21632823_ChIP-Seq_H3396_Human1.19831466
53GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19311065
54FLI1_27457419_Chip-Seq_LIVER_Mouse1.19085765
55FOXH1_21741376_ChIP-Seq_EPCs_Human1.18551266
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18126602
57SMAD4_21799915_ChIP-Seq_A2780_Human1.18076456
58RXR_22108803_ChIP-Seq_LS180_Human1.18044410
59CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.17312354
60TP53_22573176_ChIP-Seq_HFKS_Human1.16966366
61MYC_18940864_ChIP-ChIP_HL60_Human1.16365304
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14152304
63SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13776236
64KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.11693541
65FOXP3_21729870_ChIP-Seq_TREG_Human1.11109552
66ETS1_20019798_ChIP-Seq_JURKAT_Human1.09343429
67RNF2_27304074_Chip-Seq_NSC_Mouse1.09198646
68PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08699225
69CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07545264
70MYC_19829295_ChIP-Seq_ESCs_Human1.06698563
71GATA3_21878914_ChIP-Seq_MCF-7_Human1.06408246
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06387948
73PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06356033
74GATA1_22025678_ChIP-Seq_K562_Human1.04664787
75TBL1_22424771_ChIP-Seq_293T_Human1.03963702
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.03890260
77UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03808785
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03474284
79CDX2_22108803_ChIP-Seq_LS180_Human1.01876144
80SMAD4_21741376_ChIP-Seq_EPCs_Human1.01597368
81SMAD_19615063_ChIP-ChIP_OVARY_Human1.01074280
82PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00750193
83GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00102354
84EZH2_27294783_Chip-Seq_NPCs_Mouse0.99826357
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99664309
86STAT3_23295773_ChIP-Seq_U87_Human0.97817829
87CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96453453
88GATA3_26560356_Chip-Seq_TH2_Human0.94913990
89SOX2_19829295_ChIP-Seq_ESCs_Human0.94908845
90NANOG_19829295_ChIP-Seq_ESCs_Human0.94908845
91RAC3_21632823_ChIP-Seq_H3396_Human0.94047635
92PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93447154
93AR_25329375_ChIP-Seq_VCAP_Human0.91996000
94PHF8_20622853_ChIP-Seq_HELA_Human0.91675564
95ETV1_20927104_ChIP-Seq_GIST48_Human0.91653576
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91428579
97FOXA1_25329375_ChIP-Seq_VCAP_Human0.91266885
98FOXA1_27270436_Chip-Seq_PROSTATE_Human0.91266885
99NCOR_22424771_ChIP-Seq_293T_Human0.91211665
100PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91211185

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation5.19102335
2MP0000566_synostosis3.75460265
3MP0002102_abnormal_ear_morphology3.67582546
4MP0000015_abnormal_ear_pigmentation3.40345384
5MP0008877_abnormal_DNA_methylation3.19248853
6MP0003136_yellow_coat_color2.98631520
7MP0003646_muscle_fatigue2.93137130
8MP0005075_abnormal_melanosome_morpholog2.77433218
9MP0000372_irregular_coat_pigmentation2.50811968
10MP0003195_calcinosis2.47915383
11MP0005365_abnormal_bile_salt2.40307026
12MP0005174_abnormal_tail_pigmentation2.12136932
13MP0006035_abnormal_mitochondrial_morpho2.00770927
14MP0003787_abnormal_imprinting1.98273196
15MP0004381_abnormal_hair_follicle1.96104015
16MP0006072_abnormal_retinal_apoptosis1.75636193
17MP0005408_hypopigmentation1.73384177
18MP0005085_abnormal_gallbladder_physiolo1.72011826
19MP0005253_abnormal_eye_physiology1.68511397
20MP0001986_abnormal_taste_sensitivity1.68488035
21MP0005499_abnormal_olfactory_system1.64742710
22MP0005394_taste/olfaction_phenotype1.64742710
23MP0005551_abnormal_eye_electrophysiolog1.64001879
24MP0001529_abnormal_vocalization1.63048451
25MP0002638_abnormal_pupillary_reflex1.59659671
26MP0008789_abnormal_olfactory_epithelium1.50210940
27MP0006036_abnormal_mitochondrial_physio1.41664602
28MP0005171_absent_coat_pigmentation1.37503426
29MP0005410_abnormal_fertilization1.37139068
30MP0001324_abnormal_eye_pigmentation1.35881517
31MP0003119_abnormal_digestive_system1.33874249
32MP0005646_abnormal_pituitary_gland1.33437981
33MP0003567_abnormal_fetal_cardiomyocyte1.32858199
34MP0001968_abnormal_touch/_nociception1.32563804
35MP0005645_abnormal_hypothalamus_physiol1.32529928
36MP0001929_abnormal_gametogenesis1.31950562
37MP0008961_abnormal_basal_metabolism1.31142742
38MP0009840_abnormal_foam_cell1.28693103
39MP0002139_abnormal_hepatobiliary_system1.27309946
40MP0001299_abnormal_eye_distance/1.27279573
41MP0003880_abnormal_central_pattern1.25660168
42MP0008875_abnormal_xenobiotic_pharmacok1.22026769
43MP0004133_heterotaxia1.21755900
44MP0001919_abnormal_reproductive_system1.17031549
45MP0002938_white_spotting1.16789153
46MP0002210_abnormal_sex_determination1.16369476
47MP0000049_abnormal_middle_ear1.15023313
48MP0001145_abnormal_male_reproductive1.14544960
49MP0004484_altered_response_of1.14311820
50MP0003315_abnormal_perineum_morphology1.12826539
51MP0005389_reproductive_system_phenotype1.12526587
52MP0002751_abnormal_autonomic_nervous1.08120818
53MP0003806_abnormal_nucleotide_metabolis1.05840253
54MP0000653_abnormal_sex_gland1.05724856
55MP0005391_vision/eye_phenotype1.03969289
56MP0004924_abnormal_behavior1.03893213
57MP0005386_behavior/neurological_phenoty1.03893213
58MP0004142_abnormal_muscle_tone1.02653456
59MP0002095_abnormal_skin_pigmentation1.01530060
60MP0003698_abnormal_male_reproductive1.01038967
61MP0005423_abnormal_somatic_nervous0.99987776
62MP0006292_abnormal_olfactory_placode0.99746337
63MP0009046_muscle_twitch0.98868398
64MP0002572_abnormal_emotion/affect_behav0.98813342
65MP0001486_abnormal_startle_reflex0.97889334
66MP0003937_abnormal_limbs/digits/tail_de0.95341329
67MP0001764_abnormal_homeostasis0.93995663
68MP0002160_abnormal_reproductive_system0.92463631
69MP0002735_abnormal_chemical_nociception0.91683728
70MP0008995_early_reproductive_senescence0.89955804
71MP0002233_abnormal_nose_morphology0.88209094
72MP0003172_abnormal_lysosome_physiology0.88153058
73MP0004043_abnormal_pH_regulation0.84617461
74MP0004742_abnormal_vestibular_system0.83866562
75MP0001905_abnormal_dopamine_level0.83132034
76MP0003385_abnormal_body_wall0.82459446
77MP0005084_abnormal_gallbladder_morpholo0.81745313
78MP0000631_abnormal_neuroendocrine_gland0.81217642
79MP0001293_anophthalmia0.79732276
80MP0009764_decreased_sensitivity_to0.78529718
81MP0010368_abnormal_lymphatic_system0.78448252
82MP0003221_abnormal_cardiomyocyte_apopto0.76032827
83MP0010386_abnormal_urinary_bladder0.76013162
84MP0008057_abnormal_DNA_replication0.75782520
85MP0000604_amyloidosis0.75752661
86MP0005647_abnormal_sex_gland0.73965208
87MP0005248_abnormal_Harderian_gland0.73402403
88MP0001501_abnormal_sleep_pattern0.72982418
89MP0000371_diluted_coat_color0.72919560
90MP0006276_abnormal_autonomic_nervous0.71977416
91MP0005195_abnormal_posterior_eye0.71891549
92MP0003936_abnormal_reproductive_system0.71768153
93MP0009745_abnormal_behavioral_response0.71481775
94MP0001119_abnormal_female_reproductive0.71090602
95MP0000538_abnormal_urinary_bladder0.70135694
96MP0003890_abnormal_embryonic-extraembry0.68343867
97MP0001270_distended_abdomen0.67060512
98MP0003693_abnormal_embryo_hatching0.65685387
99MP0002067_abnormal_sensory_capabilities0.64859516
100MP0002332_abnormal_exercise_endurance0.64568277

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)8.51294397
2Methylmalonic aciduria (HP:0012120)6.46796597
3Absent rod-and cone-mediated responses on ERG (HP:0007688)5.25391396
4Decreased central vision (HP:0007663)4.40418253
5Progressive inability to walk (HP:0002505)4.17964607
6Tubulointerstitial nephritis (HP:0001970)3.72095019
7Dicarboxylic aciduria (HP:0003215)3.63954557
8Abnormality of dicarboxylic acid metabolism (HP:0010995)3.63954557
9Unsteady gait (HP:0002317)3.43001570
10Chronic hepatic failure (HP:0100626)3.31759797
11Attenuation of retinal blood vessels (HP:0007843)3.31206401
12Hyperglycinemia (HP:0002154)3.23936123
13Pancreatic cysts (HP:0001737)3.23242079
14True hermaphroditism (HP:0010459)3.18695617
15Cerebellar dysplasia (HP:0007033)3.13317089
16Abnormal rod and cone electroretinograms (HP:0008323)3.07649563
17Abnormality of the renal cortex (HP:0011035)2.90332406
18Amblyopia (HP:0000646)2.87660094
19Sensory axonal neuropathy (HP:0003390)2.77195973
20Inability to walk (HP:0002540)2.76803602
21Renal cortical cysts (HP:0000803)2.73121435
22Limb hypertonia (HP:0002509)2.69711872
23Methylmalonic acidemia (HP:0002912)2.69133618
24Pancreatic fibrosis (HP:0100732)2.68728988
25Enlarged kidneys (HP:0000105)2.66468168
26Abnormal protein glycosylation (HP:0012346)2.64071027
27Abnormal glycosylation (HP:0012345)2.64071027
28Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.64071027
29Abnormal protein N-linked glycosylation (HP:0012347)2.64071027
30Humeroradial synostosis (HP:0003041)2.62119012
31Synostosis involving the elbow (HP:0003938)2.62119012
32Tubulointerstitial abnormality (HP:0001969)2.54570062
33Pancreatic islet-cell hyperplasia (HP:0004510)2.50626222
34Facial diplegia (HP:0001349)2.47058807
35Abnormality of the ileum (HP:0001549)2.41485242
36Abnormality of abdominal situs (HP:0011620)2.39940978
37Abdominal situs inversus (HP:0003363)2.39940978
38Aplasia/Hypoplasia of the uvula (HP:0010293)2.39236187
39Facial hemangioma (HP:0000329)2.38274819
40Abnormality of the renal medulla (HP:0100957)2.36024044
41Supernumerary spleens (HP:0009799)2.33831592
42Nephronophthisis (HP:0000090)2.33712025
43Meckel diverticulum (HP:0002245)2.28174283
44Gaze-evoked nystagmus (HP:0000640)2.26932251
45Abolished electroretinogram (ERG) (HP:0000550)2.20352790
46Congenital stationary night blindness (HP:0007642)2.19126504
47Decreased electroretinogram (ERG) amplitude (HP:0000654)2.18789432
48Ketosis (HP:0001946)2.18291309
49Broad alveolar ridges (HP:0000187)2.17189052
50Lipid accumulation in hepatocytes (HP:0006561)2.13670728
51Type I transferrin isoform profile (HP:0003642)2.11201904
52Severe visual impairment (HP:0001141)2.10208745
53Type II lissencephaly (HP:0007260)2.08378895
54Abnormal biliary tract physiology (HP:0012439)2.05068198
55Bile duct proliferation (HP:0001408)2.05068198
56Abnormality of alanine metabolism (HP:0010916)2.00657191
57Hyperalaninemia (HP:0003348)2.00657191
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.00657191
59Retinal dysplasia (HP:0007973)1.98965248
60Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.97767310
61Macular degeneration (HP:0000608)1.96050751
62Abnormality of the fovea (HP:0000493)1.95856250
63Reduced antithrombin III activity (HP:0001976)1.94398649
64Abnormality of glycine metabolism (HP:0010895)1.94029575
65Abnormality of serine family amino acid metabolism (HP:0010894)1.94029575
66Intellectual disability, severe (HP:0010864)1.93673506
67Cystic liver disease (HP:0006706)1.93367393
68Pachygyria (HP:0001302)1.91125247
69Aplasia involving forearm bones (HP:0009822)1.89867605
70Absent forearm bone (HP:0003953)1.89867605
71Delayed CNS myelination (HP:0002188)1.89717605
72Absent radius (HP:0003974)1.89057816
73High anterior hairline (HP:0009890)1.88963885
74Sclerocornea (HP:0000647)1.88490420
75Acute encephalopathy (HP:0006846)1.87926816
76Postaxial foot polydactyly (HP:0001830)1.87313055
77Spontaneous abortion (HP:0005268)1.86104379
78Anencephaly (HP:0002323)1.85909987
79Rib fusion (HP:0000902)1.85078591
80Hand muscle atrophy (HP:0009130)1.84815160
81Congenital hepatic fibrosis (HP:0002612)1.83654810
82Tented upper lip vermilion (HP:0010804)1.79297119
83Hyperglycinuria (HP:0003108)1.77816775
84Hepatoblastoma (HP:0002884)1.77172939
85Carpal bone hypoplasia (HP:0001498)1.77156790
86Sloping forehead (HP:0000340)1.74851589
87Horseshoe kidney (HP:0000085)1.74739891
88Increased corneal curvature (HP:0100692)1.74354106
89Keratoconus (HP:0000563)1.74354106
90Increased serum pyruvate (HP:0003542)1.72858712
91Absent speech (HP:0001344)1.70896199
92Protruding tongue (HP:0010808)1.69684331
93Long clavicles (HP:0000890)1.69456833
94Male pseudohermaphroditism (HP:0000037)1.68680805
95Optic nerve hypoplasia (HP:0000609)1.68422214
96Genetic anticipation (HP:0003743)1.67987533
97Abnormality of the lower motor neuron (HP:0002366)1.66495492
98Absent thumb (HP:0009777)1.66122060
99Hypoplastic iliac wings (HP:0002866)1.65177786
100Adactyly (HP:0009776)1.64704775

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K43.84102966
2PINK13.78341060
3CDK83.00515482
4MAP2K72.77711188
5CLK12.65024481
6CSNK1A1L2.64407941
7FRK2.51000269
8TRIM282.48694628
9CASK2.45202727
10CSNK1G32.37186470
11LIMK12.33537521
12ZAK2.31429355
13PDK22.25888168
14CAMKK22.14097076
15CSNK1G12.09568583
16BCR1.98335156
17CSNK1G21.97677992
18SRPK11.91560088
19BRSK21.77775917
20BMPR1B1.77001847
21DYRK31.73823474
22PBK1.73577087
23PNCK1.72185789
24MARK31.69624680
25ADRBK21.53802942
26MAPK131.48555839
27GRK11.45132167
28SIK31.42214835
29ERBB31.42145882
30RPS6KA41.36552121
31TXK1.24104790
32VRK21.19005593
33WNK31.17330094
34MYLK1.15421775
35BRSK11.14568532
36WEE11.14472561
37DYRK21.12071856
38NEK21.11727704
39BRD41.05765375
40CSF1R1.03132612
41KDR1.03045166
42STK38L0.98235317
43ERBB40.94715260
44TNIK0.92013432
45GRK50.89719190
46TNK20.88380824
47NUAK10.86521398
48TEC0.86290172
49TIE10.81824163
50RPS6KA50.81790088
51MKNK20.79183076
52MAP4K10.77647140
53GRK70.75541942
54LATS10.72897001
55CDK190.70167360
56CDC42BPA0.70147409
57PTK2B0.67055211
58NTRK20.65917460
59MINK10.64539715
60MAPK150.63594583
61MAP4K20.63586825
62BTK0.62225883
63ADRBK10.59759949
64CDK30.58616132
65ITK0.54043676
66MST40.52920419
67TLK10.52151311
68TGFBR20.51793237
69MELK0.50509702
70CAMKK10.50106045
71OBSCN0.49186530
72FGR0.48329065
73MAP3K100.48006660
74INSRR0.46797722
75BCKDK0.46428708
76PAK30.46107339
77CSNK1D0.45083832
78TGFBR10.43883894
79ABL20.41415934
80CAMK40.40921033
81VRK10.40247299
82BLK0.39757212
83EGFR0.39135397
84RPS6KA60.37721729
85SGK4940.36807289
86SGK2230.36807289
87MUSK0.36725873
88PKN20.36396540
89MKNK10.35259474
90CSNK1A10.34004354
91KIT0.33055451
92PDGFRB0.32849778
93SIK20.32739765
94TAF10.31847432
95MAPKAPK30.31047532
96ABL10.30661007
97STK380.30041609
98MARK10.29633819
99IGF1R0.29135435
100MAP3K70.28632680

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006404.39165178
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.29175480
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.10802567
4Fanconi anemia pathway_Homo sapiens_hsa034602.76598925
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.55782048
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.48792047
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.34153277
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.29629032
9Basal transcription factors_Homo sapiens_hsa030222.15047580
10Olfactory transduction_Homo sapiens_hsa047402.01575128
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.97496323
12Steroid hormone biosynthesis_Homo sapiens_hsa001401.93493802
13Butanoate metabolism_Homo sapiens_hsa006501.83680776
14RNA degradation_Homo sapiens_hsa030181.82630080
15Nitrogen metabolism_Homo sapiens_hsa009101.70809439
16Phototransduction_Homo sapiens_hsa047441.67873427
17Peroxisome_Homo sapiens_hsa041461.66963767
18Chemical carcinogenesis_Homo sapiens_hsa052041.65104874
19Oxidative phosphorylation_Homo sapiens_hsa001901.56618380
20Regulation of autophagy_Homo sapiens_hsa041401.53478990
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.47875618
22Mismatch repair_Homo sapiens_hsa034301.47371578
23Parkinsons disease_Homo sapiens_hsa050121.46890435
24Retinol metabolism_Homo sapiens_hsa008301.44588034
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.43947046
26Linoleic acid metabolism_Homo sapiens_hsa005911.43487167
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.42445082
28Taste transduction_Homo sapiens_hsa047421.41977731
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36397169
30ABC transporters_Homo sapiens_hsa020101.35885654
31Proteasome_Homo sapiens_hsa030501.34878437
32Protein export_Homo sapiens_hsa030601.34797427
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.34400491
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.33958933
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.30387024
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.23915689
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.23152786
38Steroid biosynthesis_Homo sapiens_hsa001001.23039871
39Homologous recombination_Homo sapiens_hsa034401.19629741
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19297739
41Arachidonic acid metabolism_Homo sapiens_hsa005901.17465440
42beta-Alanine metabolism_Homo sapiens_hsa004101.17385142
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12402828
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.05474099
45RNA polymerase_Homo sapiens_hsa030201.02339450
46Nucleotide excision repair_Homo sapiens_hsa034201.00886081
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93971109
48Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92317508
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88888595
50Alzheimers disease_Homo sapiens_hsa050100.87699328
51Lysine degradation_Homo sapiens_hsa003100.87382809
52Carbon metabolism_Homo sapiens_hsa012000.84101851
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.82575129
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.82322603
55Huntingtons disease_Homo sapiens_hsa050160.82102270
56Pyrimidine metabolism_Homo sapiens_hsa002400.81610201
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80288158
58Asthma_Homo sapiens_hsa053100.79416879
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78946554
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.74061238
61N-Glycan biosynthesis_Homo sapiens_hsa005100.71656524
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69944997
63Metabolic pathways_Homo sapiens_hsa011000.65346340
64Glutathione metabolism_Homo sapiens_hsa004800.65278172
65Ether lipid metabolism_Homo sapiens_hsa005650.63493519
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63070210
67PPAR signaling pathway_Homo sapiens_hsa033200.60864457
68Glycosaminoglycan degradation_Homo sapiens_hsa005310.59497622
69Circadian rhythm_Homo sapiens_hsa047100.58444465
70Tryptophan metabolism_Homo sapiens_hsa003800.58359383
71Fatty acid elongation_Homo sapiens_hsa000620.52239543
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.49874826
73Fat digestion and absorption_Homo sapiens_hsa049750.47802291
74Viral myocarditis_Homo sapiens_hsa054160.47595449
75Purine metabolism_Homo sapiens_hsa002300.47420842
76Non-homologous end-joining_Homo sapiens_hsa034500.44922848
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43770052
78Sphingolipid metabolism_Homo sapiens_hsa006000.43332689
79GABAergic synapse_Homo sapiens_hsa047270.41385239
80Staphylococcus aureus infection_Homo sapiens_hsa051500.41175764
81Graft-versus-host disease_Homo sapiens_hsa053320.40937281
82Allograft rejection_Homo sapiens_hsa053300.40721350
83Calcium signaling pathway_Homo sapiens_hsa040200.40402423
84Autoimmune thyroid disease_Homo sapiens_hsa053200.38306360
85Tyrosine metabolism_Homo sapiens_hsa003500.38289956
86Fatty acid degradation_Homo sapiens_hsa000710.37249174
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36609842
88Wnt signaling pathway_Homo sapiens_hsa043100.36033183
89Dopaminergic synapse_Homo sapiens_hsa047280.35988663
90Circadian entrainment_Homo sapiens_hsa047130.34645221
91Complement and coagulation cascades_Homo sapiens_hsa046100.34402097
92DNA replication_Homo sapiens_hsa030300.34037392
93Melanoma_Homo sapiens_hsa052180.33331136
94Caffeine metabolism_Homo sapiens_hsa002320.30317993
95Vitamin digestion and absorption_Homo sapiens_hsa049770.28541752
96Morphine addiction_Homo sapiens_hsa050320.28008706
97Systemic lupus erythematosus_Homo sapiens_hsa053220.26809729
98Nicotine addiction_Homo sapiens_hsa050330.26321041
99Renin secretion_Homo sapiens_hsa049240.26250030
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.25190661

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