PFN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.45152404
2synaptic vesicle exocytosis (GO:0016079)5.24547863
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.19606271
4vocalization behavior (GO:0071625)5.18632573
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.94499968
6locomotory exploration behavior (GO:0035641)4.74214719
7pyrimidine nucleobase catabolic process (GO:0006208)4.73992260
8protein localization to synapse (GO:0035418)4.71214637
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.68269340
10glutamate secretion (GO:0014047)4.61124163
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.58369522
12regulation of glutamate receptor signaling pathway (GO:1900449)4.53040543
13synaptic vesicle maturation (GO:0016188)4.52191199
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.30529602
15neuronal action potential propagation (GO:0019227)4.25735092
16* regulation of synaptic vesicle exocytosis (GO:2000300)4.23929187
17neuron recognition (GO:0008038)4.20490695
18exploration behavior (GO:0035640)4.11943147
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.07987071
20neurotransmitter secretion (GO:0007269)4.01206959
21glutamate receptor signaling pathway (GO:0007215)4.00645577
22synaptic vesicle docking involved in exocytosis (GO:0016081)4.00207802
23nucleobase catabolic process (GO:0046113)3.89106435
24neuron-neuron synaptic transmission (GO:0007270)3.89016399
25synaptic transmission, glutamatergic (GO:0035249)3.88253091
26layer formation in cerebral cortex (GO:0021819)3.85768288
27regulation of synapse structural plasticity (GO:0051823)3.84002291
28neurotransmitter-gated ion channel clustering (GO:0072578)3.79938070
29regulation of neuronal synaptic plasticity (GO:0048168)3.78350652
30* regulation of synaptic vesicle transport (GO:1902803)3.78306928
31regulation of long-term neuronal synaptic plasticity (GO:0048169)3.76592441
32axonal fasciculation (GO:0007413)3.76438290
33presynaptic membrane assembly (GO:0097105)3.68973554
34dendritic spine morphogenesis (GO:0060997)3.64195449
35postsynaptic membrane organization (GO:0001941)3.60453981
36gamma-aminobutyric acid signaling pathway (GO:0007214)3.54790460
37negative regulation of synaptic transmission, GABAergic (GO:0032229)3.52886259
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.51500196
39presynaptic membrane organization (GO:0097090)3.49094874
40long-term synaptic potentiation (GO:0060291)3.47819602
41proline transport (GO:0015824)3.45740356
42positive regulation of synapse maturation (GO:0090129)3.45468814
43regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.42836077
44regulation of excitatory postsynaptic membrane potential (GO:0060079)3.42600454
45synaptic vesicle endocytosis (GO:0048488)3.39962688
46neurotransmitter transport (GO:0006836)3.38653150
47transmission of nerve impulse (GO:0019226)3.35792528
48gamma-aminobutyric acid transport (GO:0015812)3.33461537
49regulation of postsynaptic membrane potential (GO:0060078)3.29332297
50long-term memory (GO:0007616)3.27879335
51regulation of dendritic spine morphogenesis (GO:0061001)3.27473676
52regulation of synaptic transmission, glutamatergic (GO:0051966)3.23860556
53cell migration in hindbrain (GO:0021535)3.22249785
54positive regulation of membrane potential (GO:0045838)3.22074728
55regulation of synaptic plasticity (GO:0048167)3.21447750
56dendrite morphogenesis (GO:0048813)3.20808014
57synapse assembly (GO:0007416)3.20367489
58regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.20050269
59negative regulation of microtubule polymerization (GO:0031115)3.17291330
60limb bud formation (GO:0060174)3.15104496
61positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.14105434
62positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.13793329
63regulation of vesicle fusion (GO:0031338)3.12582314
64innervation (GO:0060384)3.12422201
65establishment of mitochondrion localization (GO:0051654)3.11884376
66positive regulation of synapse assembly (GO:0051965)3.11165088
67regulation of neurotransmitter levels (GO:0001505)3.09206186
68negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.08991223
69positive regulation of synaptic transmission, GABAergic (GO:0032230)3.07428727
70G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.07309695
71* regulation of neurotransmitter secretion (GO:0046928)3.05389501
72response to histamine (GO:0034776)3.02879939
73regulation of glutamate secretion (GO:0014048)3.01832798
74activation of protein kinase A activity (GO:0034199)2.98511870
75response to auditory stimulus (GO:0010996)2.98185120
76cellular potassium ion homeostasis (GO:0030007)2.97321705
77learning (GO:0007612)2.96717833
78startle response (GO:0001964)2.96183357
79behavioral defense response (GO:0002209)2.95972891
80behavioral fear response (GO:0001662)2.95972891
81auditory behavior (GO:0031223)2.94907246
82regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.92666007
83cerebellar granule cell differentiation (GO:0021707)2.92163894
84synapse organization (GO:0050808)2.91676196
85positive regulation of neurotransmitter transport (GO:0051590)2.91507398
86membrane depolarization (GO:0051899)2.90872135
87behavioral response to cocaine (GO:0048148)2.90808933
88synaptic transmission (GO:0007268)2.89080979
89* regulation of neurotransmitter transport (GO:0051588)2.87545550
90membrane hyperpolarization (GO:0060081)2.87186612
91positive regulation of neurotransmitter secretion (GO:0001956)2.86009320
92regulation of dendritic spine development (GO:0060998)2.85832670
93membrane depolarization during action potential (GO:0086010)2.85244122
94establishment of synaptic vesicle localization (GO:0097480)2.84530605
95synaptic vesicle transport (GO:0048489)2.84530605
96vesicle transport along microtubule (GO:0047496)2.84174113
97regulation of respiratory system process (GO:0044065)2.84007247
98positive regulation of synaptic transmission (GO:0050806)2.83207992
99organelle transport along microtubule (GO:0072384)2.82823378
100fear response (GO:0042596)2.81464091
101cerebellar Purkinje cell differentiation (GO:0021702)2.81361029
102mating behavior (GO:0007617)2.80287674
103calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.79472446
104* regulation of synaptic transmission (GO:0050804)2.78975466
105prepulse inhibition (GO:0060134)2.78349279
106central nervous system projection neuron axonogenesis (GO:0021952)2.75631342
107intraciliary transport (GO:0042073)2.73342360
108neuronal ion channel clustering (GO:0045161)2.73334186
109glycosphingolipid biosynthetic process (GO:0006688)2.71029126
110hippocampus development (GO:0021766)2.70752145
111retinal ganglion cell axon guidance (GO:0031290)2.67727663
112positive regulation of dendritic spine morphogenesis (GO:0061003)2.67510367
113nonmotile primary cilium assembly (GO:0035058)2.64168375
114regulation of synapse assembly (GO:0051963)2.64089886
115positive regulation of mitochondrial fission (GO:0090141)2.57240421
116cerebral cortex radially oriented cell migration (GO:0021799)2.55023133
117mechanosensory behavior (GO:0007638)2.52294823
118axon extension (GO:0048675)2.51547479
119glial cell proliferation (GO:0014009)2.49298372
120apical protein localization (GO:0045176)2.45741038
121cytoskeleton-dependent intracellular transport (GO:0030705)2.34249726
122neuromuscular synaptic transmission (GO:0007274)2.32867828
123central nervous system neuron axonogenesis (GO:0021955)2.32808030
124regulation of development, heterochronic (GO:0040034)2.29833401
125spinal cord development (GO:0021510)2.29404233
126dendritic spine organization (GO:0097061)2.29177916
127olfactory bulb development (GO:0021772)2.28321772
128ephrin receptor signaling pathway (GO:0048013)2.27283126
129negative regulation of axon extension (GO:0030517)2.27280567
130epithelial cilium movement (GO:0003351)2.27157767
131negative regulation of oligodendrocyte differentiation (GO:0048715)2.22938029
132microtubule-based transport (GO:0010970)2.22754727
133axonogenesis (GO:0007409)2.19886302
134asymmetric protein localization (GO:0008105)2.18465402
135peptidyl-cysteine modification (GO:0018198)2.16677748
136forebrain neuron differentiation (GO:0021879)2.16546959
137neuron migration (GO:0001764)2.16361671
138regulation of synapse organization (GO:0050807)2.16124732
139negative regulation of axonogenesis (GO:0050771)2.15943464
140ganglion development (GO:0061548)2.15921430
141axon cargo transport (GO:0008088)2.15226092
142negative regulation of axon guidance (GO:1902668)2.13845296
143neuron projection extension (GO:1990138)2.12945233

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.86009027
2GBX2_23144817_ChIP-Seq_PC3_Human3.87295386
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14972464
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.06240861
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.99716765
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.72697706
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66820677
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66820677
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.66106316
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.63563511
11REST_21632747_ChIP-Seq_MESCs_Mouse2.62393691
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.61951249
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58642339
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50122183
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.42076057
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.40274610
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.37209599
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.28375621
19TAF15_26573619_Chip-Seq_HEK293_Human2.23409372
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22220524
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.19805419
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.16187540
23RARB_27405468_Chip-Seq_BRAIN_Mouse2.15389182
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.13901665
25SALL1_21062744_ChIP-ChIP_HESCs_Human2.11680113
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09500484
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.06180965
28DROSHA_22980978_ChIP-Seq_HELA_Human2.00358613
29AR_21572438_ChIP-Seq_LNCaP_Human1.99133882
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98475622
31* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95184236
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.87906206
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.75759181
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.74579801
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73155240
36* SMAD4_21799915_ChIP-Seq_A2780_Human1.69676875
37CBX2_27304074_Chip-Seq_ESCs_Mouse1.69218322
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.67220876
39P300_19829295_ChIP-Seq_ESCs_Human1.66910738
40* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63365047
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.60617555
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.60382498
43ZNF274_21170338_ChIP-Seq_K562_Hela1.59450997
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57968349
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56085075
46* EWS_26573619_Chip-Seq_HEK293_Human1.52244983
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51205502
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50124495
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46881481
50RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46467361
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45735793
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.42021577
53* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41647370
54* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41354942
55RNF2_27304074_Chip-Seq_NSC_Mouse1.40450888
56FUS_26573619_Chip-Seq_HEK293_Human1.39659042
57* SMAD3_21741376_ChIP-Seq_EPCs_Human1.39256825
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.38034409
59IGF1R_20145208_ChIP-Seq_DFB_Human1.35963331
60POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35743426
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34835554
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.34254565
63VDR_22108803_ChIP-Seq_LS180_Human1.34087554
64WT1_19549856_ChIP-ChIP_CCG9911_Human1.33735425
65* AR_25329375_ChIP-Seq_VCAP_Human1.33587436
66SOX2_21211035_ChIP-Seq_LN229_Gbm1.32132372
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.29598061
68RING1B_27294783_Chip-Seq_ESCs_Mouse1.26919594
69* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21913742
70EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21478562
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20642109
72FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.20279762
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19276178
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18535947
75STAT3_23295773_ChIP-Seq_U87_Human1.18427521
76* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15475446
77ER_23166858_ChIP-Seq_MCF-7_Human1.10860330
78MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10392465
79P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10093042
80RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09550132
81STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09312096
82RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09205074
83AR_19668381_ChIP-Seq_PC3_Human1.08691478
84TCF4_23295773_ChIP-Seq_U87_Human1.08379303
85RUNX2_22187159_ChIP-Seq_PCA_Human1.07773471
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07141344
87RING1B_27294783_Chip-Seq_NPCs_Mouse1.06782178
88MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06445242
89PRDM14_20953172_ChIP-Seq_ESCs_Human1.06382308
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.05862001
91JUN_21703547_ChIP-Seq_K562_Human1.05647073
92HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.05082380
93TBX3_20139965_ChIP-Seq_MESCs_Mouse1.04450698
94TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03513489
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03368926
96ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03232991
97YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03068116
98CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02032239
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01943133
100SOX2_16153702_ChIP-ChIP_HESCs_Human1.01408931
101TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00888811
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99936869
103POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.99839806
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98832532
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98832532
106LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98420494
107KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97870780
108AHR_22903824_ChIP-Seq_MCF-7_Human0.97389853
109SMAD_19615063_ChIP-ChIP_OVARY_Human0.96868459
110* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96854185
111FLI1_27457419_Chip-Seq_LIVER_Mouse0.96837727
112EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96734274
113TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96259787
114* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95522948
115* NANOG_18555785_Chip-Seq_ESCs_Mouse0.92823037
116* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92478151
117SMAD3_21741376_ChIP-Seq_ESCs_Human0.92304039
118TP53_18474530_ChIP-ChIP_U2OS_Human0.89996153
119BCAT_22108803_ChIP-Seq_LS180_Human0.89460068
120SOX9_26525672_Chip-Seq_HEART_Mouse0.88137199
121DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87667620
122SMAD4_21741376_ChIP-Seq_HESCs_Human0.87191467
123KDM2B_26808549_Chip-Seq_REH_Human0.87122837
124CBP_20019798_ChIP-Seq_JUKART_Human0.85959378
125IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.85959378

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.39108880
2MP0003880_abnormal_central_pattern5.09552260
3* MP0003635_abnormal_synaptic_transmissio3.80078183
4MP0004270_analgesia3.60708485
5MP0009745_abnormal_behavioral_response3.19927813
6* MP0002063_abnormal_learning/memory/cond3.14825201
7MP0001968_abnormal_touch/_nociception3.03727072
8MP0002064_seizures3.02667699
9MP0009046_muscle_twitch2.85161748
10* MP0002572_abnormal_emotion/affect_behav2.70261259
11MP0005423_abnormal_somatic_nervous2.65183672
12MP0002734_abnormal_mechanical_nocicepti2.63946147
13MP0002736_abnormal_nociception_after2.55603914
14MP0002272_abnormal_nervous_system2.52827658
15MP0001486_abnormal_startle_reflex2.44732850
16MP0002735_abnormal_chemical_nociception2.42161616
17MP0001440_abnormal_grooming_behavior2.27949731
18MP0000778_abnormal_nervous_system2.26611256
19MP0006276_abnormal_autonomic_nervous2.25345624
20MP0002822_catalepsy2.14178008
21MP0001529_abnormal_vocalization2.14034698
22MP0002733_abnormal_thermal_nociception2.06841496
23MP0002184_abnormal_innervation2.03956161
24MP0002067_abnormal_sensory_capabilities2.03894009
25MP0001501_abnormal_sleep_pattern2.01291870
26MP0001970_abnormal_pain_threshold1.97866490
27MP0001984_abnormal_olfaction1.90532364
28MP0003329_amyloid_beta_deposits1.82986325
29MP0002557_abnormal_social/conspecific_i1.78780530
30MP0004858_abnormal_nervous_system1.77009070
31MP0004924_abnormal_behavior1.74727542
32MP0005386_behavior/neurological_phenoty1.74727542
33MP0004811_abnormal_neuron_physiology1.65961654
34MP0009780_abnormal_chondrocyte_physiolo1.65799407
35MP0005646_abnormal_pituitary_gland1.64426500
36MP0001905_abnormal_dopamine_level1.62126472
37MP0008569_lethality_at_weaning1.61120606
38* MP0000955_abnormal_spinal_cord1.57310607
39MP0003122_maternal_imprinting1.57232542
40MP0003787_abnormal_imprinting1.54329571
41* MP0002882_abnormal_neuron_morphology1.50215504
42MP0005645_abnormal_hypothalamus_physiol1.48085408
43MP0000049_abnormal_middle_ear1.48036283
44MP0004142_abnormal_muscle_tone1.47642773
45MP0002066_abnormal_motor_capabilities/c1.41293745
46MP0002234_abnormal_pharynx_morphology1.39988918
47MP0002233_abnormal_nose_morphology1.34632759
48MP0002909_abnormal_adrenal_gland1.34129627
49MP0000566_synostosis1.32761452
50MP0004885_abnormal_endolymph1.30729206
51MP0004133_heterotaxia1.29830902
52MP0003136_yellow_coat_color1.28323742
53MP0001188_hyperpigmentation1.26145408
54MP0000751_myopathy1.25679846
55MP0005187_abnormal_penis_morphology1.24272174
56MP0001502_abnormal_circadian_rhythm1.23967757
57MP0005248_abnormal_Harderian_gland1.23431107
58MP0004742_abnormal_vestibular_system1.22740007
59MP0003937_abnormal_limbs/digits/tail_de1.22017838
60MP0003879_abnormal_hair_cell1.21840005
61MP0002837_dystrophic_cardiac_calcinosis1.21459972
62* MP0002152_abnormal_brain_morphology1.16687518
63MP0003119_abnormal_digestive_system1.14524304
64MP0005551_abnormal_eye_electrophysiolog1.14356554
65MP0003755_abnormal_palate_morphology1.14043285
66MP0003385_abnormal_body_wall1.12833344
67MP0006292_abnormal_olfactory_placode1.10284435
68MP0003633_abnormal_nervous_system1.10233123
69MP0002938_white_spotting1.08829962
70MP0004145_abnormal_muscle_electrophysio1.08598245
71MP0005499_abnormal_olfactory_system1.06503750
72MP0005394_taste/olfaction_phenotype1.06503750
73MP0003890_abnormal_embryonic-extraembry1.06484046
74MP0003631_nervous_system_phenotype1.03470232
75MP0002229_neurodegeneration1.00767536
76MP0010030_abnormal_orbit_morphology1.00153619
77MP0008877_abnormal_DNA_methylation1.00014260
78MP0003634_abnormal_glial_cell0.99085380
79MP0002752_abnormal_somatic_nervous0.98690023
80MP0000631_abnormal_neuroendocrine_gland0.98029558
81MP0001963_abnormal_hearing_physiology0.95839816
82MP0010386_abnormal_urinary_bladder0.95051623
83MP0001293_anophthalmia0.94676480
84MP0003283_abnormal_digestive_organ0.94041203
85MP0002069_abnormal_eating/drinking_beha0.92182765
86MP0002697_abnormal_eye_size0.90190034
87MP0002249_abnormal_larynx_morphology0.87209918
88MP0001286_abnormal_eye_development0.85415984
89MP0000534_abnormal_ureter_morphology0.85139098
90MP0002638_abnormal_pupillary_reflex0.85123518
91MP0002876_abnormal_thyroid_physiology0.83865609
92MP0000013_abnormal_adipose_tissue0.82354702
93MP0002081_perinatal_lethality0.81838972
94MP0003632_abnormal_nervous_system0.81678796
95MP0005391_vision/eye_phenotype0.81307175
96MP0000920_abnormal_myelination0.81264028
97MP0001485_abnormal_pinna_reflex0.81082910
98MP0000579_abnormal_nail_morphology0.79380210
99MP0004085_abnormal_heartbeat0.79302331
100MP0008872_abnormal_physiological_respon0.79076191
101MP0000537_abnormal_urethra_morphology0.78992025
102MP0003935_abnormal_craniofacial_develop0.77068291
103MP0000647_abnormal_sebaceous_gland0.76870438
104MP0001177_atelectasis0.76399403
105MP0003123_paternal_imprinting0.76351446
106MP0004215_abnormal_myocardial_fiber0.76346614
107MP0003942_abnormal_urinary_system0.76106139
108MP0000604_amyloidosis0.73617530
109MP0003861_abnormal_nervous_system0.71531731
110MP0003137_abnormal_impulse_conducting0.70725727
111MP0000026_abnormal_inner_ear0.70188693
112MP0002090_abnormal_vision0.69459041
113MP0006072_abnormal_retinal_apoptosis0.69148955
114MP0005409_darkened_coat_color0.68846328
115MP0005535_abnormal_body_temperature0.68485002
116MP0005171_absent_coat_pigmentation0.67867381
117MP0001664_abnormal_digestion0.66852487
118MP0001943_abnormal_respiration0.65646480
119MP0002751_abnormal_autonomic_nervous0.65567043
120MP0008874_decreased_physiological_sensi0.64829359
121MP0004233_abnormal_muscle_weight0.64373077
122MP0003690_abnormal_glial_cell0.64203023
123MP0008789_abnormal_olfactory_epithelium0.63929059
124MP0003121_genomic_imprinting0.63821064
125MP0004484_altered_response_of0.62027187
126MP0005623_abnormal_meninges_morphology0.59206713
127MP0001299_abnormal_eye_distance/0.59080115
128MP0002653_abnormal_ependyma_morphology0.55290284
129MP0002102_abnormal_ear_morphology0.55079479
130MP0005253_abnormal_eye_physiology0.53085120
131MP0003938_abnormal_ear_development0.52817610

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.85285953
2Myokymia (HP:0002411)5.89781604
3Focal seizures (HP:0007359)5.08583116
4Atonic seizures (HP:0010819)4.63033499
5Visual hallucinations (HP:0002367)4.58204233
6Epileptic encephalopathy (HP:0200134)4.49741167
7Febrile seizures (HP:0002373)4.14061412
8Progressive cerebellar ataxia (HP:0002073)3.92305227
9Absence seizures (HP:0002121)3.90337035
10Hyperventilation (HP:0002883)3.72976650
11Dialeptic seizures (HP:0011146)3.62955583
12Generalized tonic-clonic seizures (HP:0002069)3.41541859
13Supranuclear gaze palsy (HP:0000605)3.35784690
14Broad-based gait (HP:0002136)3.32276242
15Limb dystonia (HP:0002451)3.15703758
16Amblyopia (HP:0000646)3.14063071
17Action tremor (HP:0002345)3.08279254
18Pheochromocytoma (HP:0002666)3.02992816
19Ankle clonus (HP:0011448)3.02900616
20Split foot (HP:0001839)3.00746792
21Impaired vibration sensation in the lower limbs (HP:0002166)2.95805635
22Cerebral inclusion bodies (HP:0100314)2.88964997
23Neurofibrillary tangles (HP:0002185)2.82298560
24Progressive inability to walk (HP:0002505)2.82297245
25Anxiety (HP:0000739)2.81461584
26Termporal pattern (HP:0011008)2.81085456
27Insidious onset (HP:0003587)2.81085456
28Abnormal eating behavior (HP:0100738)2.78628324
29Truncal ataxia (HP:0002078)2.76849793
30Drooling (HP:0002307)2.73598240
31Excessive salivation (HP:0003781)2.73598240
32Abnormality of the labia minora (HP:0012880)2.73007008
33Neuroendocrine neoplasm (HP:0100634)2.71689898
34Polyphagia (HP:0002591)2.68343100
35Depression (HP:0000716)2.67672105
36Abnormality of the corticospinal tract (HP:0002492)2.65980051
37Dysdiadochokinesis (HP:0002075)2.63779980
38Poor eye contact (HP:0000817)2.63481829
39Dysmetria (HP:0001310)2.62292339
40Mutism (HP:0002300)2.60306415
41Cortical dysplasia (HP:0002539)2.57626333
42Urinary bladder sphincter dysfunction (HP:0002839)2.56672845
43Gaze-evoked nystagmus (HP:0000640)2.56198481
44Gait imbalance (HP:0002141)2.55846651
45Urinary urgency (HP:0000012)2.50205948
46Epileptiform EEG discharges (HP:0011182)2.46518953
47Spastic gait (HP:0002064)2.43284851
48Hemiparesis (HP:0001269)2.40100214
49Abnormality of binocular vision (HP:0011514)2.39295521
50Diplopia (HP:0000651)2.39295521
51Megalencephaly (HP:0001355)2.37120119
52EEG with generalized epileptiform discharges (HP:0011198)2.34961163
53Impaired social interactions (HP:0000735)2.34899418
54Abnormal social behavior (HP:0012433)2.34899418
55Hepatoblastoma (HP:0002884)2.31861153
56Degeneration of the lateral corticospinal tracts (HP:0002314)2.31639677
57Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.31639677
58Fetal akinesia sequence (HP:0001989)2.30333333
59Absent speech (HP:0001344)2.26946168
60Inability to walk (HP:0002540)2.25237315
61Intestinal atresia (HP:0011100)2.25221585
62True hermaphroditism (HP:0010459)2.21855458
63Hypsarrhythmia (HP:0002521)2.20633339
64Lower limb muscle weakness (HP:0007340)2.20629238
65Scanning speech (HP:0002168)2.17022804
66Amyotrophic lateral sclerosis (HP:0007354)2.16747522
67Postural instability (HP:0002172)2.13585267
68Specific learning disability (HP:0001328)2.13481057
69Torticollis (HP:0000473)2.08494738
70Abnormality of the lower motor neuron (HP:0002366)2.08494592
71Congenital primary aphakia (HP:0007707)2.07585569
72Hypoplasia of the brainstem (HP:0002365)2.07198541
73Aplasia/Hypoplasia of the brainstem (HP:0007362)2.07198541
74Medial flaring of the eyebrow (HP:0010747)2.06175246
75Abnormal hair whorl (HP:0010721)2.04982993
76Pancreatic fibrosis (HP:0100732)2.04132123
77Bradykinesia (HP:0002067)2.03425520
78Focal dystonia (HP:0004373)2.03218221
79Shoulder girdle muscle weakness (HP:0003547)2.02589767
80Agitation (HP:0000713)2.01542629
81Oligodactyly (hands) (HP:0001180)1.99629442
82Failure to thrive in infancy (HP:0001531)1.99273131
83Acute necrotizing encephalopathy (HP:0006965)1.99021708
84Delusions (HP:0000746)1.97532879
85Septo-optic dysplasia (HP:0100842)1.97166100
86Genetic anticipation (HP:0003743)1.94699903
87Generalized myoclonic seizures (HP:0002123)1.94147800
88Stereotypic behavior (HP:0000733)1.93127786
89Postaxial hand polydactyly (HP:0001162)1.92757806
90Akinesia (HP:0002304)1.90926028
91Nephrogenic diabetes insipidus (HP:0009806)1.90830192
92Blue irides (HP:0000635)1.90622437
93Nephronophthisis (HP:0000090)1.89698262
94Progressive macrocephaly (HP:0004481)1.88768272
95Impaired vibratory sensation (HP:0002495)1.87455243
96Retinal dysplasia (HP:0007973)1.87328380
97Hypoventilation (HP:0002791)1.87077626
98Genital tract atresia (HP:0001827)1.86469787
99Abnormality of salivation (HP:0100755)1.85517865
100Poor suck (HP:0002033)1.85352241
101Broad foot (HP:0001769)1.84578317
102Abnormal mitochondria in muscle tissue (HP:0008316)1.83925916
103Optic nerve hypoplasia (HP:0000609)1.83205007
104Poor coordination (HP:0002370)1.83158162
105Esotropia (HP:0000565)1.83046220
106Pancreatic cysts (HP:0001737)1.82876520
107Vaginal atresia (HP:0000148)1.81774533
108Lissencephaly (HP:0001339)1.81653585
109Pachygyria (HP:0001302)1.81310195
110Hyperthyroidism (HP:0000836)1.80630815
111Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.80193207
112Intention tremor (HP:0002080)1.80068144
113Occipital encephalocele (HP:0002085)1.79946453
114Spastic tetraplegia (HP:0002510)1.79845154
115Incomplete penetrance (HP:0003829)1.78899367
116Craniofacial dystonia (HP:0012179)1.78473439
117Delayed gross motor development (HP:0002194)1.77487675
118Abnormality of midbrain morphology (HP:0002418)1.76470553
119Molar tooth sign on MRI (HP:0002419)1.76470553
120Impaired smooth pursuit (HP:0007772)1.75972396
121Psychosis (HP:0000709)1.75465218
122Gait ataxia (HP:0002066)1.75432837
123Abnormality of the musculature of the pelvis (HP:0001469)1.74894080
124Abnormality of the hip-girdle musculature (HP:0001445)1.74894080
125Decreased testicular size (HP:0008734)1.74217762
126Renal hypoplasia (HP:0000089)1.73166587
127Micropenis (HP:0000054)1.72188388
128Heterochromia iridis (HP:0001100)1.69684549
129Abnormal respiratory epithelium morphology (HP:0012253)1.65639224
130Abnormal respiratory motile cilium morphology (HP:0005938)1.65639224
131Bifid tongue (HP:0010297)1.62017122
132Narrow forehead (HP:0000341)1.61707641
133Exercise-induced muscle cramps (HP:0003710)1.60534628
134Abnormality of the metopic suture (HP:0005556)1.59976356
135Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.59736360
136Oligodactyly (HP:0012165)1.58374884
137Postaxial foot polydactyly (HP:0001830)1.58181444
138Sleep apnea (HP:0010535)1.57560316
139Aplasia/Hypoplasia of the tongue (HP:0010295)1.54930153
140Anophthalmia (HP:0000528)1.53781274
141Scrotal hypoplasia (HP:0000046)1.53352952
142Muscular hypotonia of the trunk (HP:0008936)1.52372990
143Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.51522642
144Aplasia/Hypoplasia of the lens (HP:0008063)1.50485561
145Gastrointestinal atresia (HP:0002589)1.50455748
146Cutaneous finger syndactyly (HP:0010554)1.49728902
147Labial hypoplasia (HP:0000066)1.49605162
148Preaxial hand polydactyly (HP:0001177)1.49589732
149Morphological abnormality of the pyramidal tract (HP:0002062)1.49568510
150Hypoplasia of the corpus callosum (HP:0002079)1.48859894
151Abnormal ciliary motility (HP:0012262)1.47399599
152Abnormal respiratory motile cilium physiology (HP:0012261)1.46931430
153Decreased lacrimation (HP:0000633)1.45548175
154Sclerocornea (HP:0000647)1.45085143

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.95311013
2MARK13.77647923
3NTRK33.77562447
4MAP3K43.20464986
5CASK3.16920088
6MAP3K92.96461827
7MAP2K72.89629462
8MINK12.77500089
9TRIM282.64526127
10MAP3K122.60448531
11NTRK22.05579021
12MAP2K42.02292157
13DAPK21.91147660
14PLK21.85923452
15MAPK131.84452874
16PAK61.80201117
17PNCK1.71086748
18RIPK41.67896029
19KSR11.62378775
20SRPK11.60783030
21MAP4K21.59756890
22GRK51.56865371
23NTRK11.56847753
24KSR21.56831005
25TNIK1.50872438
26ARAF1.50489692
27PHKG21.48059291
28PHKG11.48059291
29STK38L1.47795411
30CDK191.47641511
31CDK51.42871250
32PRPF4B1.39337762
33CSNK1A1L1.34289783
34CSNK1G11.32568479
35DAPK11.32141519
36UHMK11.31467523
37TYRO31.28173097
38EPHB21.26694238
39EPHA31.24989044
40PRKCG1.21876279
41OXSR11.15459609
42FES1.13697245
43SIK21.13600988
44FGFR21.12838590
45CAMK2A1.10731830
46NME11.10565038
47SGK4941.08685524
48SGK2231.08685524
49PRKD31.05946806
50CAMKK11.04116375
51PLK31.01173020
52NEK10.99212965
53MKNK20.96316981
54CAMK2B0.95320566
55CDK140.95037180
56CDK180.94916151
57BCR0.93986827
58TSSK60.92613915
59BMPR20.90854171
60CDK150.89684294
61MKNK10.89568727
62PTK2B0.87925796
63LATS20.87879655
64DYRK1A0.87335388
65CSNK1G20.86642995
66FRK0.86221938
67BMPR1B0.86030486
68LIMK10.85961972
69DYRK30.85437769
70PAK30.84141324
71SIK30.82457221
72DYRK20.81194696
73CDK11A0.77532092
74WEE10.76232683
75MAP3K20.75134392
76RPS6KA40.74595030
77SGK20.71934356
78CAMKK20.71575464
79FGR0.71427196
80STK380.70671765
81LMTK20.68655139
82PRKCE0.68119067
83STK390.68070870
84DYRK1B0.65385627
85ERBB30.63957154
86RET0.63797322
87WNK30.63601169
88RAF10.62375596
89ROCK20.61779905
90GRK70.61187350
91PLK40.60514834
92PINK10.59517658
93CCNB10.59372320
94ERBB40.58158364
95CAMK2D0.57347408
96SGK10.55623113
97MARK20.55400619
98PLK10.55251746
99PKN10.54798327
100STK110.53647710
101ADRBK10.52075224
102CAMK2G0.51431019
103CAMK10.49365263
104CSNK1G30.49178607
105PDK40.48697995
106PDK30.48697995
107BRSK10.48455942
108FER0.48419719
109MAP3K130.48289836
110PRKCZ0.47664658
111TESK10.46557422
112BRAF0.46184780
113MAPK150.45740555
114CSNK1E0.45036299
115TTK0.45017524
116PRKCH0.43562618
117MAP2K10.43560846
118BRD40.43422968
119CDK30.40700681
120WNK40.40369591
121CSNK1D0.39401607
122AKT30.39205286
123MAP3K60.39142503
124SGK30.38981626
125WNK10.38695772
126CSNK1A10.37816748
127FYN0.37132633
128ERBB20.36965343
129RPS6KA30.36326705
130BUB10.36235511
131ROCK10.35796709
132BCKDK0.34973652
133PDPK10.34173121
134MAPK100.33800695
135RPS6KA20.33654927
136PRKACB0.31381222
137FGFR10.30847606
138PRKDC0.30844527

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.86906312
2Synaptic vesicle cycle_Homo sapiens_hsa047213.46379134
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.75857890
4GABAergic synapse_Homo sapiens_hsa047272.67431258
5Olfactory transduction_Homo sapiens_hsa047402.62491766
6Circadian entrainment_Homo sapiens_hsa047132.54164344
7Long-term potentiation_Homo sapiens_hsa047202.49660806
8Glutamatergic synapse_Homo sapiens_hsa047242.47740221
9Morphine addiction_Homo sapiens_hsa050322.43322473
10Amphetamine addiction_Homo sapiens_hsa050312.35829812
11Collecting duct acid secretion_Homo sapiens_hsa049662.28246579
12Dopaminergic synapse_Homo sapiens_hsa047282.24805924
13Protein export_Homo sapiens_hsa030602.03600293
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.03424906
15Salivary secretion_Homo sapiens_hsa049701.96334130
16Serotonergic synapse_Homo sapiens_hsa047261.88876601
17Taste transduction_Homo sapiens_hsa047421.88450747
18Cholinergic synapse_Homo sapiens_hsa047251.86231859
19Insulin secretion_Homo sapiens_hsa049111.78994211
20Long-term depression_Homo sapiens_hsa047301.74317862
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.73567537
22Gastric acid secretion_Homo sapiens_hsa049711.71713007
23Renin secretion_Homo sapiens_hsa049241.69668865
24Vitamin B6 metabolism_Homo sapiens_hsa007501.69564531
25Oxidative phosphorylation_Homo sapiens_hsa001901.61550677
26Cocaine addiction_Homo sapiens_hsa050301.58043102
27Oxytocin signaling pathway_Homo sapiens_hsa049211.52921486
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52579805
29Steroid biosynthesis_Homo sapiens_hsa001001.50916616
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.50822322
31Calcium signaling pathway_Homo sapiens_hsa040201.50288313
32Vibrio cholerae infection_Homo sapiens_hsa051101.47580694
33Axon guidance_Homo sapiens_hsa043601.39333677
34Gap junction_Homo sapiens_hsa045401.39153599
35Cardiac muscle contraction_Homo sapiens_hsa042601.38223479
36GnRH signaling pathway_Homo sapiens_hsa049121.37017725
37Alzheimers disease_Homo sapiens_hsa050101.31278885
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.31203848
39Hippo signaling pathway_Homo sapiens_hsa043901.29545350
40Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27889248
41Propanoate metabolism_Homo sapiens_hsa006401.27303982
42Hedgehog signaling pathway_Homo sapiens_hsa043401.27189097
43Parkinsons disease_Homo sapiens_hsa050121.25795000
44Basal cell carcinoma_Homo sapiens_hsa052171.24839538
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22167084
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.21576726
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21198312
48Phototransduction_Homo sapiens_hsa047441.17417569
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09285308
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.07607330
51cAMP signaling pathway_Homo sapiens_hsa040241.07166794
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02820810
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01227443
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.98931935
55Estrogen signaling pathway_Homo sapiens_hsa049150.98012085
56Melanogenesis_Homo sapiens_hsa049160.97811926
57ErbB signaling pathway_Homo sapiens_hsa040120.96308658
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95181714
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94130685
60Glioma_Homo sapiens_hsa052140.94066910
61beta-Alanine metabolism_Homo sapiens_hsa004100.91838083
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90690949
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89472095
64Oocyte meiosis_Homo sapiens_hsa041140.87205318
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.86543831
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.84784075
67Huntingtons disease_Homo sapiens_hsa050160.84749918
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.81433787
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79901073
70Type II diabetes mellitus_Homo sapiens_hsa049300.79023104
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77561548
72Tight junction_Homo sapiens_hsa045300.77292343
73Fatty acid elongation_Homo sapiens_hsa000620.76732227
74Basal transcription factors_Homo sapiens_hsa030220.76134303
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71499297
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69771526
77Pyruvate metabolism_Homo sapiens_hsa006200.68185471
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67825788
79Arginine and proline metabolism_Homo sapiens_hsa003300.66510087
80Dorso-ventral axis formation_Homo sapiens_hsa043200.65792592
81Folate biosynthesis_Homo sapiens_hsa007900.65662449
82Pancreatic secretion_Homo sapiens_hsa049720.65059188
83Dilated cardiomyopathy_Homo sapiens_hsa054140.64851985
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.64849169
85Choline metabolism in cancer_Homo sapiens_hsa052310.63591609
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.63219132
87mRNA surveillance pathway_Homo sapiens_hsa030150.62500004
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62481500
89MAPK signaling pathway_Homo sapiens_hsa040100.61921757
90Thyroid hormone synthesis_Homo sapiens_hsa049180.60933638
91Biosynthesis of amino acids_Homo sapiens_hsa012300.59595917
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59576044
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57686822
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57504672
95Fatty acid metabolism_Homo sapiens_hsa012120.56718460
96Ras signaling pathway_Homo sapiens_hsa040140.56515632
97Alcoholism_Homo sapiens_hsa050340.56503462
98Fanconi anemia pathway_Homo sapiens_hsa034600.54908750
99RNA degradation_Homo sapiens_hsa030180.54552542
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53817723
101Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53508424
102Glucagon signaling pathway_Homo sapiens_hsa049220.53204140
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.51973501
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.51631781
105Non-homologous end-joining_Homo sapiens_hsa034500.50794854
106VEGF signaling pathway_Homo sapiens_hsa043700.50334572
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.47911107
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.47755734
109Renal cell carcinoma_Homo sapiens_hsa052110.47480302
110Prion diseases_Homo sapiens_hsa050200.46223014
111Neurotrophin signaling pathway_Homo sapiens_hsa047220.46144157
112Rheumatoid arthritis_Homo sapiens_hsa053230.45721615
113Wnt signaling pathway_Homo sapiens_hsa043100.45566486
114Spliceosome_Homo sapiens_hsa030400.45341739
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45180267
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44892682
117Carbon metabolism_Homo sapiens_hsa012000.44520383
118RNA polymerase_Homo sapiens_hsa030200.43639589
119AMPK signaling pathway_Homo sapiens_hsa041520.43242479
120Regulation of autophagy_Homo sapiens_hsa041400.42630146
121Phagosome_Homo sapiens_hsa041450.42531001
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41470157
123Peroxisome_Homo sapiens_hsa041460.41459501
124TGF-beta signaling pathway_Homo sapiens_hsa043500.41198641
125Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41167326
126* Rap1 signaling pathway_Homo sapiens_hsa040150.39934295
127Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38106810
128Endometrial cancer_Homo sapiens_hsa052130.37140186
129Type I diabetes mellitus_Homo sapiens_hsa049400.36752694
130Endocytosis_Homo sapiens_hsa041440.36478313
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36053698
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34086490
133Ovarian steroidogenesis_Homo sapiens_hsa049130.33664392
134Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33309117
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33213634
136Butanoate metabolism_Homo sapiens_hsa006500.33053303
137Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32235683
138Insulin signaling pathway_Homo sapiens_hsa049100.31699749
139Circadian rhythm_Homo sapiens_hsa047100.31626315
140Colorectal cancer_Homo sapiens_hsa052100.31448357
141Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31164031
142African trypanosomiasis_Homo sapiens_hsa051430.30462414
143Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30134804
144Inositol phosphate metabolism_Homo sapiens_hsa005620.27596620

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