PFN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the profilin family of proteins. This protein binds to actin and affects the structure of the cytoskeleton. It also may be involved in spermatogenesis. It is a single exon gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)9.23953359
2drug transmembrane transport (GO:0006855)9.23331038
3urate metabolic process (GO:0046415)9.09690771
4cell wall macromolecule catabolic process (GO:0016998)8.21340867
5cell wall macromolecule metabolic process (GO:0044036)8.21340867
6sperm motility (GO:0030317)8.04156487
7drug transport (GO:0015893)7.70999417
8quaternary ammonium group transport (GO:0015697)7.16114919
9acrosome reaction (GO:0007340)7.03533764
10phosphate ion transport (GO:0006817)6.80122521
11lysine metabolic process (GO:0006553)6.60183154
12lysine catabolic process (GO:0006554)6.60183154
13fusion of sperm to egg plasma membrane (GO:0007342)6.47180431
14acrosome assembly (GO:0001675)6.20684444
15sperm-egg recognition (GO:0035036)6.15341942
16response to mercury ion (GO:0046689)6.09314030
17drug catabolic process (GO:0042737)6.08326198
18exogenous drug catabolic process (GO:0042738)6.06253978
19amino-acid betaine transport (GO:0015838)5.88243412
20carnitine transport (GO:0015879)5.88243412
21binding of sperm to zona pellucida (GO:0007339)5.62423145
22glyoxylate metabolic process (GO:0046487)5.53708072
23cell-cell recognition (GO:0009988)5.46937386
24phosphate ion transmembrane transport (GO:0035435)5.43340556
25spermatid development (GO:0007286)5.41426544
26fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.25125651
27cysteine metabolic process (GO:0006534)5.15512891
28multicellular organism reproduction (GO:0032504)5.12106873
29aspartate family amino acid catabolic process (GO:0009068)5.07129304
30excretion (GO:0007588)5.06814451
31nonribosomal peptide biosynthetic process (GO:0019184)5.03611694
32motile cilium assembly (GO:0044458)4.90255098
33plasma membrane fusion (GO:0045026)4.89232316
34tricarboxylic acid metabolic process (GO:0072350)4.82814224
35epithelial cilium movement (GO:0003351)4.74869175
36reproduction (GO:0000003)4.70726378
37fructose metabolic process (GO:0006000)4.67702219
38axonemal dynein complex assembly (GO:0070286)4.59727140
39polyol catabolic process (GO:0046174)4.53709383
40glutathione biosynthetic process (GO:0006750)4.51489423
41phosphate ion homeostasis (GO:0055062)4.45395003
42trivalent inorganic anion homeostasis (GO:0072506)4.45395003
43short-chain fatty acid metabolic process (GO:0046459)4.41313981
44renal absorption (GO:0070293)4.29821368
45proline metabolic process (GO:0006560)4.27076407
46toxin transport (GO:1901998)4.24844318
47negative regulation of inclusion body assembly (GO:0090084)4.22016506
48amino-acid betaine metabolic process (GO:0006577)4.14554049
49regulation of cilium movement (GO:0003352)4.13357942
50glycoside metabolic process (GO:0016137)4.08236634
51carnitine transmembrane transport (GO:1902603)4.05079760
52sperm capacitation (GO:0048240)4.03567339
53erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.02853942
54L-phenylalanine catabolic process (GO:0006559)4.02853942
55carnitine metabolic process (GO:0009437)3.99743964
56L-phenylalanine metabolic process (GO:0006558)3.98753133
57erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.98753133
58alditol metabolic process (GO:0019400)3.98591183
59vitamin D metabolic process (GO:0042359)3.97663231
60branched-chain amino acid metabolic process (GO:0009081)3.96784458
61homocysteine metabolic process (GO:0050667)3.96445254
62metanephric nephron tubule development (GO:0072234)3.92260820
63metanephric tubule development (GO:0072170)3.92260820
64spermatogenesis (GO:0007283)3.87048701
65male gamete generation (GO:0048232)3.85216110
66aromatic amino acid family catabolic process (GO:0009074)3.75868360
67serine family amino acid catabolic process (GO:0009071)3.75149095
68single fertilization (GO:0007338)3.72137278
69fatty acid beta-oxidation (GO:0006635)3.71208773
70cilium movement (GO:0003341)3.70871782
71cellular modified amino acid catabolic process (GO:0042219)3.68795166
72synaptonemal complex assembly (GO:0007130)3.67680913
73valine metabolic process (GO:0006573)3.66112343
74synaptonemal complex organization (GO:0070193)3.64641738
75serine family amino acid metabolic process (GO:0009069)3.62886014
76glutathione derivative biosynthetic process (GO:1901687)3.60645064
77glutathione derivative metabolic process (GO:1901685)3.60645064
78modified amino acid transport (GO:0072337)3.59071918
79metanephric nephron epithelium development (GO:0072243)3.58257676
80glycerol metabolic process (GO:0006071)3.57281162
81nephron tubule development (GO:0072080)3.56204214
82gamete generation (GO:0007276)3.52331733
83peptide catabolic process (GO:0043171)3.51407825
84peptide biosynthetic process (GO:0043043)3.51001311
85glutathione metabolic process (GO:0006749)3.49070631
86glycerol ether metabolic process (GO:0006662)3.49060624
87cellular carbohydrate catabolic process (GO:0044275)3.48957873
88tryptophan catabolic process (GO:0006569)3.48040263
89indole-containing compound catabolic process (GO:0042436)3.48040263
90indolalkylamine catabolic process (GO:0046218)3.48040263
91chromosome condensation (GO:0030261)3.47432886
92polyol transport (GO:0015791)3.39058578
93regulation of inclusion body assembly (GO:0090083)3.37767319
94response to parathyroid hormone (GO:0071107)3.34818308
95fatty acid oxidation (GO:0019395)3.32145237
96tryptophan metabolic process (GO:0006568)3.29278214
97metanephric epithelium development (GO:0072207)3.28164846
98sexual reproduction (GO:0019953)3.25894643
99lipid oxidation (GO:0034440)3.25583162
100organic cation transport (GO:0015695)11.4311608

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.27266558
2PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.37914540
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.95263699
4VDR_22108803_ChIP-Seq_LS180_Human2.86105135
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.76787798
6RXR_22158963_ChIP-Seq_LIVER_Mouse2.63077002
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.44610872
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.37173044
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.35339336
10EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.25888837
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.25438632
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77699605
13ZNF274_21170338_ChIP-Seq_K562_Hela1.71828019
14* SOX2_22085726_ChIP-Seq_NPCs_Mouse1.63895613
15STAT6_21828071_ChIP-Seq_BEAS2B_Human1.62284773
16STAT1_17558387_ChIP-Seq_HELA_Human1.59509034
17GATA1_26923725_Chip-Seq_HPCs_Mouse1.54128706
18* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53055086
19GATA3_21867929_ChIP-Seq_CD8_Mouse1.52597863
20RAD21_21589869_ChIP-Seq_MESCs_Mouse1.50662702
21EZH2_22144423_ChIP-Seq_EOC_Human1.45651987
22WDR5_24793694_ChIP-Seq_LNCAP_Human1.45641839
23TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41160622
24CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38185079
25PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.37072566
26* TET1_21451524_ChIP-Seq_MESCs_Mouse1.35281698
27GATA1_19941827_ChIP-Seq_MEL86_Mouse1.31414093
28CBP_20019798_ChIP-Seq_JUKART_Human1.30924938
29IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30924938
30CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.30168815
31ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.27824854
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.24005151
33LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.22378761
34MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.22172875
35ESET_19884257_ChIP-Seq_ESCs_Mouse1.21005772
36PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20261608
37SOX11_22085726_ChIP-Seq_ESNs_Mouse1.20254260
38GF1_26923725_Chip-Seq_HPCs_Mouse1.18958849
39SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18807997
40FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.18356266
41* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18203337
42KDM2B_26808549_Chip-Seq_REH_Human1.17232245
43P53_21459846_ChIP-Seq_SAOS-2_Human1.15251561
44* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15090120
45KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14919586
46PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.14637957
47* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.13083999
48RXRA_24833708_ChIP-Seq_LIVER_Mouse1.12941500
49KAP1_22055183_ChIP-Seq_ESCs_Mouse1.12837152
50TBX20_22080862_ChIP-Seq_HEART_Mouse1.12127082
51TBX20_22328084_ChIP-Seq_HEART_Mouse1.12127082
52CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11270731
53SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.10173744
54GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.09975104
55RAC3_21632823_ChIP-Seq_H3396_Human1.09630770
56SMC4_20622854_ChIP-Seq_HELA_Human1.09194137
57CSB_26484114_Chip-Seq_FIBROBLAST_Human1.08973169
58TAL1_26923725_Chip-Seq_HPCs_Mouse1.08909612
59* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08889774
60CTCF_27219007_Chip-Seq_Bcells_Human1.07900298
61TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07651600
62CTCF_20526341_ChIP-Seq_ESCs_Human1.07111532
63JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.05282989
64ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04647155
65PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.04377142
66ERG_20517297_ChIP-Seq_VCAP_Human1.01971840
67RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01644045
68SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01267871
69MYC_19915707_ChIP-ChIP_AK7_Human1.01111507
70PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00004364
71SMAD4_21741376_ChIP-Seq_EPCs_Human0.99644535
72SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99359425
73MYC_27129775_Chip-Seq_CORNEA_Mouse0.99110733
74ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98400161
75PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.98012812
76SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97299571
77* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96984423
78ELK4_26923725_Chip-Seq_MESODERM_Mouse0.95742239
79BCOR_27268052_Chip-Seq_Bcells_Human0.94979910
80* TP63_22573176_ChIP-Seq_HFKS_Human0.93658942
81CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93308419
82SOX2_27498859_Chip-Seq_STOMACH_Mouse0.93168600
83LXR_22292898_ChIP-Seq_THP-1_Human0.92470503
84TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.92348735
85SOX2_21211035_ChIP-Seq_LN229_Human0.91980085
86YY1_22570637_ChIP-Seq_MALME-3M_Human0.90842150
87* HNF4A_19822575_ChIP-Seq_HepG2_Human0.90207725
88* OCT1_27270436_Chip-Seq_PROSTATE_Human0.89099218
89AR_21909140_ChIP-Seq_LNCAP_Human0.89009352
90EGR1_23403033_ChIP-Seq_LIVER_Mouse0.88694849
91ESR1_21235772_ChIP-Seq_MCF-7_Human0.88661050
92FLI1_21867929_ChIP-Seq_TH2_Mouse0.88358491
93SPI1_26923725_Chip-Seq_HPCs_Mouse0.88214925
94* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.86851318
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86141932
96FOXA2_19822575_ChIP-Seq_HepG2_Human0.85666922
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85287528
98EP300_21415370_ChIP-Seq_HL-1_Mouse0.85015710
99P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.84124326
100GF1B_26923725_Chip-Seq_HPCs_Mouse0.83968231

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.00970238
2MP0005360_urolithiasis6.41091883
3MP0004043_abnormal_pH_regulation5.91171067
4MP0002139_abnormal_hepatobiliary_system4.51913592
5MP0004019_abnormal_vitamin_homeostasis4.40172266
6MP0005332_abnormal_amino_acid4.25739171
7MP0001765_abnormal_ion_homeostasis3.95622137
8MP0009643_abnormal_urine_homeostasis3.38611584
9MP0002138_abnormal_hepatobiliary_system3.29724829
10MP0005636_abnormal_mineral_homeostasis3.08997747
11MP0003195_calcinosis3.08773594
12MP0005377_hearing/vestibular/ear_phenot2.70685175
13MP0003878_abnormal_ear_physiology2.70685175
14MP0003698_abnormal_male_reproductive2.68247932
15MP0008875_abnormal_xenobiotic_pharmacok2.60660675
16MP0001756_abnormal_urination2.56646891
17MP0002136_abnormal_kidney_physiology2.53972279
18MP0005670_abnormal_white_adipose2.53567901
19MP0001929_abnormal_gametogenesis2.43522955
20MP0001958_emphysema2.13488159
21MP0003252_abnormal_bile_duct2.05659769
22MP0005365_abnormal_bile_salt1.79066951
23MP0005085_abnormal_gallbladder_physiolo1.78093040
24MP0003646_muscle_fatigue1.77085294
25MP0002161_abnormal_fertility/fecundity1.58619142
26MP0008961_abnormal_basal_metabolism1.57061814
27MP0005058_abnormal_lysosome_morphology1.54135083
28MP0003186_abnormal_redox_activity1.53087339
29MP0004885_abnormal_endolymph1.50113601
30MP0006036_abnormal_mitochondrial_physio1.46585386
31MP0005584_abnormal_enzyme/coenzyme_acti1.43984896
32MP0002928_abnormal_bile_duct1.31594390
33MP0005084_abnormal_gallbladder_morpholo1.31422967
34MP0005451_abnormal_body_composition1.27910260
35MP0005319_abnormal_enzyme/_coenzyme1.27669171
36MP0001145_abnormal_male_reproductive1.24421398
37MP0000538_abnormal_urinary_bladder1.19453189
38MP0005666_abnormal_adipose_tissue1.15303117
39MP0002210_abnormal_sex_determination1.15022161
40MP0003806_abnormal_nucleotide_metabolis1.14169027
41MP0004233_abnormal_muscle_weight1.10144440
42MP0001764_abnormal_homeostasis1.08710574
43MP0002168_other_aberrant_phenotype1.05629727
44MP0000230_abnormal_systemic_arterial1.00849295
45MP0000653_abnormal_sex_gland0.97520534
46MP0002876_abnormal_thyroid_physiology0.96736800
47MP0005535_abnormal_body_temperature0.95834376
48MP0002135_abnormal_kidney_morphology0.93109448
49MP0003300_gastrointestinal_ulcer0.81262769
50MP0002118_abnormal_lipid_homeostasis0.80190189
51MP0003329_amyloid_beta_deposits0.77145041
52MP0002896_abnormal_bone_mineralization0.75924921
53MP0001661_extended_life_span0.72938781
54MP0002089_abnormal_postnatal_growth/wei0.69015293
55MP0009642_abnormal_blood_homeostasis0.68038227
56MP0004264_abnormal_extraembryonic_tissu0.65855273
57MP0003172_abnormal_lysosome_physiology0.63981406
58MP0008877_abnormal_DNA_methylation0.62076828
59MP0004742_abnormal_vestibular_system0.61889403
60MP0006035_abnormal_mitochondrial_morpho0.60150170
61MP0003879_abnormal_hair_cell0.59536640
62MP0003283_abnormal_digestive_organ0.58385844
63MP0004147_increased_porphyrin_level0.57559789
64MP0003959_abnormal_lean_body0.56569944
65MP0002653_abnormal_ependyma_morphology0.56313188
66MP0002160_abnormal_reproductive_system0.54302692
67MP0003638_abnormal_response/metabolism_0.53937411
68MP0001666_abnormal_nutrient_absorption0.51382621
69MP0001485_abnormal_pinna_reflex0.51287254
70MP0010329_abnormal_lipoprotein_level0.50155803
71MP0002796_impaired_skin_barrier0.50028120
72MP0005395_other_phenotype0.48621322
73MP0000609_abnormal_liver_physiology0.48576403
74MP0000534_abnormal_ureter_morphology0.46497702
75MP0005375_adipose_tissue_phenotype0.44394619
76MP0003953_abnormal_hormone_level0.43461807
77MP0008469_abnormal_protein_level0.42596045
78MP0009764_decreased_sensitivity_to0.42550059
79MP0002115_abnormal_skeleton_extremities0.42411416
80MP0000371_diluted_coat_color0.42395117
81MP0000747_muscle_weakness0.42142056
82MP0000598_abnormal_liver_morphology0.40973509
83MP0002078_abnormal_glucose_homeostasis0.38165842
84MP0000678_abnormal_parathyroid_gland0.36919735
85MP0009672_abnormal_birth_weight0.36201510
86MP0002069_abnormal_eating/drinking_beha0.35089807
87MP0003191_abnormal_cellular_cholesterol0.34799603
88MP0005408_hypopigmentation0.33440026
89MP0002971_abnormal_brown_adipose0.33399785
90MP0005647_abnormal_sex_gland0.33044186
91MP0001963_abnormal_hearing_physiology0.31206763
92MP0001293_anophthalmia0.30903760
93MP0003633_abnormal_nervous_system0.30655891
94MP0002269_muscular_atrophy0.29165158
95MP0004036_abnormal_muscle_relaxation0.28051424
96MP0005501_abnormal_skin_physiology0.27974440
97MP0000604_amyloidosis0.27420257
98MP0005220_abnormal_exocrine_pancreas0.27153607
99MP0000358_abnormal_cell_content/0.27118780
100MP0003795_abnormal_bone_structure0.26927775

Predicted human phenotypes

RankGene SetZ-score
1Increased circulating renin level (HP:0000848)7.22396469
2Hypokalemic alkalosis (HP:0001949)6.86614681
3Metabolic alkalosis (HP:0200114)6.59683278
4Gout (HP:0001997)6.55822373
5Polyuria (HP:0000103)6.53799203
6Hypomagnesemia (HP:0002917)6.35578303
7Abnormal urine output (HP:0012590)6.26742624
8Hyperactive renin-angiotensin system (HP:0000841)6.14688506
9Abnormality of renal excretion (HP:0011036)6.14464932
10Abnormality of chloride homeostasis (HP:0011422)5.91993111
11Abnormal drinking behavior (HP:0030082)5.77341358
12Polydipsia (HP:0001959)5.77341358
13Abnormality of magnesium homeostasis (HP:0004921)5.36881172
14Proximal tubulopathy (HP:0000114)4.99970282
15Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.83944879
16Increased purine levels (HP:0004368)4.68948616
17Hyperuricemia (HP:0002149)4.68948616
18Dynein arm defect of respiratory motile cilia (HP:0012255)4.68843642
19Absent/shortened dynein arms (HP:0200106)4.68843642
20Tetany (HP:0001281)4.46779453
21Alkalosis (HP:0001948)4.41148272
22Abnormality of renin-angiotensin system (HP:0000847)4.40269255
23Renal salt wasting (HP:0000127)4.30172085
24Hyperaldosteronism (HP:0000859)4.17563859
25Abnormality of purine metabolism (HP:0004352)4.10526110
26Hyperglycinuria (HP:0003108)4.08598514
27Abnormality of glutamine family amino acid metabolism (HP:0010902)4.02018407
28Chronic bronchitis (HP:0004469)3.78021776
29Hypercalciuria (HP:0002150)3.66280559
30Generalized aminoaciduria (HP:0002909)3.65932025
31Abnormality of glycine metabolism (HP:0010895)3.32426474
32Abnormality of serine family amino acid metabolism (HP:0010894)3.32426474
33Abnormal respiratory motile cilium physiology (HP:0012261)3.30810731
34Abnormality of urine glucose concentration (HP:0011016)3.26483011
35Glycosuria (HP:0003076)3.26483011
36Hypokalemia (HP:0002900)3.26326964
37Renal tubular acidosis (HP:0001947)3.26209240
38Ketoacidosis (HP:0001993)3.21903534
39Ketosis (HP:0001946)3.11113408
40Abnormal respiratory motile cilium morphology (HP:0005938)3.03163501
41Abnormal respiratory epithelium morphology (HP:0012253)3.03163501
42Delayed epiphyseal ossification (HP:0002663)3.01043727
43Abnormality of nucleobase metabolism (HP:0010932)2.98929603
44Abnormality of potassium homeostasis (HP:0011042)2.97225459
45Tubular atrophy (HP:0000092)2.91418988
46Vascular calcification (HP:0004934)2.91415231
47Nephrocalcinosis (HP:0000121)2.89740087
48Hyperphosphaturia (HP:0003109)2.87973495
49Infertility (HP:0000789)2.79989377
50Abnormal urine phosphate concentration (HP:0012599)2.70427295
51Tubulointerstitial fibrosis (HP:0005576)2.67418320
52Rhinitis (HP:0012384)2.62094973
53Cardiovascular calcification (HP:0011915)2.59206366
54Hydroxyprolinuria (HP:0003080)2.55491982
55Abnormality of proline metabolism (HP:0010907)2.55491982
56Nephrolithiasis (HP:0000787)2.50011865
57Widely patent fontanelles and sutures (HP:0004492)2.42356805
58Abnormality of renal resorption (HP:0011038)2.41828245
59Nasal polyposis (HP:0100582)2.37928741
60Abnormality of aspartate family amino acid metabolism (HP:0010899)2.36961511
61Malnutrition (HP:0004395)2.35031730
62Hypophosphatemia (HP:0002148)2.32844260
63Metaphyseal cupping (HP:0003021)2.31883505
64Abnormality of fatty-acid metabolism (HP:0004359)2.29318669
65Hyperglycinemia (HP:0002154)2.26457609
66Rickets (HP:0002748)2.26262277
67Abnormal ciliary motility (HP:0012262)2.23052556
68Tubulointerstitial abnormality (HP:0001969)2.21499280
69Abnormality of the renal medulla (HP:0100957)2.15492623
70Dehydration (HP:0001944)2.08087360
71Generalized muscle weakness (HP:0003324)2.04759595
72Abnormality of the nasal mucosa (HP:0000433)2.04216888
73Enlarged kidneys (HP:0000105)2.04006868
74Hyponatremia (HP:0002902)2.01760645
75Hyperammonemia (HP:0001987)2.01258540
76Delayed CNS myelination (HP:0002188)2.01182278
77Abnormal enzyme/coenzyme activity (HP:0012379)2.00121171
78Dicarboxylic aciduria (HP:0003215)1.99974294
79Abnormality of dicarboxylic acid metabolism (HP:0010995)1.99974294
80Abnormality of sodium homeostasis (HP:0010931)1.98816107
81Facial shape deformation (HP:0011334)1.95890352
82Potter facies (HP:0002009)1.95890352
83Abnormality of alkaline phosphatase activity (HP:0004379)1.94798524
84Metabolic acidosis (HP:0001942)1.94611064
85Vomiting (HP:0002013)1.94387097
86Vacuolated lymphocytes (HP:0001922)1.92400042
87Hyperkalemia (HP:0002153)1.92358660
88Adrenal overactivity (HP:0002717)1.91487517
89Renal tubular dysfunction (HP:0000124)1.88092635
90Confusion (HP:0001289)1.87496314
91Abnormality of the renal cortex (HP:0011035)1.86472554
92Methylmalonic aciduria (HP:0012120)1.85964571
93Abnormality of aromatic amino acid family metabolism (HP:0004338)1.82217172
94Male infertility (HP:0003251)1.81302491
95Bronchitis (HP:0012387)1.75154405
96Abnormal tarsal ossification (HP:0008369)1.73370641
97Thin bony cortex (HP:0002753)1.72642111
98Lethargy (HP:0001254)1.71687102
99Polyphagia (HP:0002591)1.67656890
100Abnormality of the costochondral junction (HP:0000919)1.64753625

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK48.24633957
2OXSR15.41834858
3WNK35.40431680
4PDK45.31247194
5PDK35.31247194
6STK394.69077601
7TESK13.95886102
8PDK23.53452115
9PRKD32.80180466
10ICK2.56172174
11STK382.23187683
12STK38L2.16538046
13BCKDK1.96760919
14WNK11.91506083
15PTK2B1.44489879
16DYRK1B1.25961468
17SGK4941.23362873
18SGK2231.23362873
19NEK11.09209480
20PINK11.03195734
21PDK10.97050173
22PDPK10.88123030
23MST1R0.70088242
24PNCK0.68414791
25IRAK10.55819432
26NEK20.55764992
27MAPK150.55443140
28IRAK20.51351871
29SGK20.50880504
30EPHB10.48349180
31PAK40.47352581
32GSK3A0.46998014
33SGK30.46787611
34PRKAA10.44542520
35FGFR40.40644361
36LRRK20.39167987
37GRK60.38811652
38MST40.35706352
39RIPK40.34415982
40PRKCZ0.34325784
41SGK10.31309003
42TIE10.26321320
43PRKCG0.25873340
44TTK0.25457541
45TYRO30.24839998
46PTK20.24198127
47STK30.23687350
48STK110.23019350
49DYRK30.22669998
50STK100.21965766
51TRIB30.20815704
52ABL20.20702031
53MAP2K60.20395106
54MAP3K70.19260190
55TGFBR20.17091033
56PRKCD0.16904579
57PRKAA20.16087242
58PRKD20.14869976
59EEF2K0.14108164
60TESK20.13481895
61MAPK110.12925300
62PRKACG0.12436643
63PIM10.12314200
64PTK60.12238410
65LATS10.11833034
66CAMK1G0.11058277
67MET0.10256450
68MAP3K30.09844073
69MTOR0.09792856
70MARK20.09782201
71PRKCQ0.09490199
72PRKCA0.08162215
73PAK30.05935364
74RIPK10.05378514
75PAK10.05121717
76PRKACA0.04780939
77LMTK20.04158502
78MINK10.03890460
79MAP3K100.03617676
80MYLK0.02814663
81ERN10.02514771
82INSRR0.01626734
83NTRK20.01615937
84FER0.01329489
85NTRK10.01291611
86RPS6KA1-5.6688148
87IGF1R-0.0488648
88PRKACB-0.0458225
89INSR-0.0451334
90SRC-0.0422953
91BMX-0.0422364
92MAP2K4-0.0388093
93RPS6KA3-0.0314724
94CHEK2-0.0310537
95TAOK1-0.0273150
96PAK2-0.0128864
97MARK3-0.0127306
98PRKG2-0.0007046
99PRKCI-0.0004227
100EPHA4-0.0001233

Predicted pathways (KEGG)

RankGene SetZ-score
1Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049643.80190494
2Propanoate metabolism_Homo sapiens_hsa006403.52431245
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.36486613
4Butanoate metabolism_Homo sapiens_hsa006503.35540006
5Pyruvate metabolism_Homo sapiens_hsa006203.11842487
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006303.11182329
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.07552697
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.00056173
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.71225422
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.65522330
11Fatty acid degradation_Homo sapiens_hsa000712.53407356
12Collecting duct acid secretion_Homo sapiens_hsa049662.45263129
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.30790034
14Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.23991469
15Peroxisome_Homo sapiens_hsa041462.23280743
16Fatty acid metabolism_Homo sapiens_hsa012121.99627651
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.94669334
18Carbon metabolism_Homo sapiens_hsa012001.84562644
19Tryptophan metabolism_Homo sapiens_hsa003801.82717753
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.81878945
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.80519271
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.79178990
23Glutathione metabolism_Homo sapiens_hsa004801.77249590
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.64465020
25beta-Alanine metabolism_Homo sapiens_hsa004101.63792885
26Sulfur metabolism_Homo sapiens_hsa009201.61931748
27Vitamin digestion and absorption_Homo sapiens_hsa049771.60286567
28Bile secretion_Homo sapiens_hsa049761.59604573
29PPAR signaling pathway_Homo sapiens_hsa033201.55283452
30Mineral absorption_Homo sapiens_hsa049781.50659339
31Selenocompound metabolism_Homo sapiens_hsa004501.44721935
32Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.44023568
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41508905
34Glycerolipid metabolism_Homo sapiens_hsa005611.36162431
35Carbohydrate digestion and absorption_Homo sapiens_hsa049731.29679129
36Arginine and proline metabolism_Homo sapiens_hsa003301.28183152
37Protein digestion and absorption_Homo sapiens_hsa049741.21415762
38Fructose and mannose metabolism_Homo sapiens_hsa000511.18625151
39Other glycan degradation_Homo sapiens_hsa005111.14425215
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10020413
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07437463
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03036061
43Biosynthesis of amino acids_Homo sapiens_hsa012301.01806304
44Lysine degradation_Homo sapiens_hsa003100.98929293
45Primary bile acid biosynthesis_Homo sapiens_hsa001200.93094665
46Starch and sucrose metabolism_Homo sapiens_hsa005000.91304411
47Histidine metabolism_Homo sapiens_hsa003400.91120972
48Cysteine and methionine metabolism_Homo sapiens_hsa002700.89729737
49Fatty acid biosynthesis_Homo sapiens_hsa000610.87719603
50Glycosaminoglycan degradation_Homo sapiens_hsa005310.85848133
51Phenylalanine metabolism_Homo sapiens_hsa003600.85660351
52Pentose phosphate pathway_Homo sapiens_hsa000300.84251989
53Renin-angiotensin system_Homo sapiens_hsa046140.80763804
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71404119
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70307900
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69861110
57Arginine biosynthesis_Homo sapiens_hsa002200.69774005
58Chemical carcinogenesis_Homo sapiens_hsa052040.69318381
59Thyroid hormone synthesis_Homo sapiens_hsa049180.69096402
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68363626
61Oxidative phosphorylation_Homo sapiens_hsa001900.66295388
62Glucagon signaling pathway_Homo sapiens_hsa049220.66278333
63Nitrogen metabolism_Homo sapiens_hsa009100.61963654
64Arachidonic acid metabolism_Homo sapiens_hsa005900.59256435
65Metabolic pathways_Homo sapiens_hsa011000.59083829
66Linoleic acid metabolism_Homo sapiens_hsa005910.53578828
67Gastric acid secretion_Homo sapiens_hsa049710.53573388
68Cardiac muscle contraction_Homo sapiens_hsa042600.53406392
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.49598843
70Vitamin B6 metabolism_Homo sapiens_hsa007500.46789710
71Folate biosynthesis_Homo sapiens_hsa007900.46572757
72Synaptic vesicle cycle_Homo sapiens_hsa047210.45929618
73Fatty acid elongation_Homo sapiens_hsa000620.43025622
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.36706529
75Vibrio cholerae infection_Homo sapiens_hsa051100.32809542
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.31455348
77Parkinsons disease_Homo sapiens_hsa050120.31109379
78Lysosome_Homo sapiens_hsa041420.30398125
79Retinol metabolism_Homo sapiens_hsa008300.29993679
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.28381851
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.27675334
82ABC transporters_Homo sapiens_hsa020100.25713324
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.25383262
84Fat digestion and absorption_Homo sapiens_hsa049750.23760292
85Inositol phosphate metabolism_Homo sapiens_hsa005620.22495617
86Huntingtons disease_Homo sapiens_hsa050160.22141500
87Hedgehog signaling pathway_Homo sapiens_hsa043400.20896789
88Sulfur relay system_Homo sapiens_hsa041220.20292294
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.19664423
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.18420457
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16874078
92AMPK signaling pathway_Homo sapiens_hsa041520.14280858
93Tyrosine metabolism_Homo sapiens_hsa003500.12825664
94Ether lipid metabolism_Homo sapiens_hsa005650.12417533
95Sphingolipid metabolism_Homo sapiens_hsa006000.08510385
96Choline metabolism in cancer_Homo sapiens_hsa052310.08045327
97Insulin resistance_Homo sapiens_hsa049310.07555317
98Alzheimers disease_Homo sapiens_hsa050100.07103794
99Pancreatic secretion_Homo sapiens_hsa049720.06286197
100Galactose metabolism_Homo sapiens_hsa000520.03806972

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