PGA5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of megakaryocyte differentiation (GO:0045654)9.72713747
2cellular response to zinc ion (GO:0071294)8.79235910
3thrombin receptor signaling pathway (GO:0070493)8.46710810
4positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)8.22434865
5* digestion (GO:0007586)7.91345434
6tyrosine phosphorylation of STAT protein (GO:0007260)7.77911542
7transcytosis (GO:0045056)7.68862300
8production of molecular mediator involved in inflammatory response (GO:0002532)7.16118923
9low-density lipoprotein particle clearance (GO:0034383)7.14545010
10peptidyl-proline hydroxylation (GO:0019511)6.85251564
11regulation of sequestering of triglyceride (GO:0010889)6.68765622
12cellular response to cadmium ion (GO:0071276)6.25712121
13negative regulation of digestive system process (GO:0060457)6.14102392
14intestinal absorption (GO:0050892)5.97575410
15COPI coating of Golgi vesicle (GO:0048205)5.94070446
16Golgi transport vesicle coating (GO:0048200)5.94070446
17valine metabolic process (GO:0006573)5.46976684
18protein hydroxylation (GO:0018126)5.46807092
19leukotriene biosynthetic process (GO:0019370)5.28623148
20exocrine pancreas development (GO:0031017)5.20045010
21citrulline biosynthetic process (GO:0019240)5.03875285
22regulation of phospholipase A2 activity (GO:0032429)4.89941162
23lipid storage (GO:0019915)4.76913899
24cholesterol catabolic process (GO:0006707)4.73324263
25sterol catabolic process (GO:0016127)4.73324263
26triglyceride catabolic process (GO:0019433)4.61646224
27angiotensin maturation (GO:0002003)4.60946830
28positive regulation of Rho protein signal transduction (GO:0035025)4.59835962
29positive regulation of lipid storage (GO:0010884)4.50429468
30platelet dense granule organization (GO:0060155)4.42320588
31diacylglycerol metabolic process (GO:0046339)4.39651155
32neutral lipid catabolic process (GO:0046461)4.32426117
33acylglycerol catabolic process (GO:0046464)4.32426117
34branched-chain amino acid catabolic process (GO:0009083)4.24726323
35branched-chain amino acid metabolic process (GO:0009081)4.12062423
36membrane lipid catabolic process (GO:0046466)4.02550123
37cobalamin metabolic process (GO:0009235)4.02225617
38regulation of megakaryocyte differentiation (GO:0045652)4.00057414
39negative regulation of bone resorption (GO:0045779)3.95641814
40membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.91223042
41activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.88891266
42glycolipid catabolic process (GO:0019377)3.87162850
43negative regulation of lipid storage (GO:0010888)3.84002620
44maintenance of protein localization in organelle (GO:0072595)3.79405274
45positive regulation of nuclease activity (GO:0032075)3.72988433
46regulation of lipid storage (GO:0010883)3.72505034
47regulation of glomerular filtration (GO:0003093)3.72259638
48actin nucleation (GO:0045010)3.66320630
49insulin-like growth factor receptor signaling pathway (GO:0048009)3.61758356
504-hydroxyproline metabolic process (GO:0019471)3.58956280
51L-alpha-amino acid transmembrane transport (GO:1902475)3.58931070
52germ cell migration (GO:0008354)3.57569960
53coenzyme catabolic process (GO:0009109)3.56685079
54response to laminar fluid shear stress (GO:0034616)3.53155593
55COPII vesicle coating (GO:0048208)3.50530207
56positive regulation of interleukin-8 secretion (GO:2000484)3.49607716
57regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.49117473
58positive regulation of histone deacetylation (GO:0031065)3.48938249
59potassium ion export (GO:0071435)3.47029952
60negative regulation of platelet activation (GO:0010544)3.46475783
61positive regulation of pseudopodium assembly (GO:0031274)3.45534978
62membrane repolarization during action potential (GO:0086011)3.44356074
63hydrogen peroxide metabolic process (GO:0042743)3.43851371
64cysteine metabolic process (GO:0006534)3.43055190
65regulation of triglyceride catabolic process (GO:0010896)3.42534281
66mannose metabolic process (GO:0006013)3.41862819
67cardiovascular system development (GO:0072358)3.40393918
68regulation of heterotypic cell-cell adhesion (GO:0034114)3.39826015
69actin filament capping (GO:0051693)3.38545571
70regulation of nuclease activity (GO:0032069)3.34418838
71positive regulation of glomerulus development (GO:0090193)3.33201308
72plasma lipoprotein particle clearance (GO:0034381)3.29012267
73ceramide catabolic process (GO:0046514)3.28067087
74branching involved in labyrinthine layer morphogenesis (GO:0060670)3.27276101
75fatty acid homeostasis (GO:0055089)3.25003127
76megakaryocyte development (GO:0035855)3.23784640
77positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.22398987
78negative regulation of protein autophosphorylation (GO:0031953)3.20665516
79N-glycan processing (GO:0006491)3.19504948
80regulation of uterine smooth muscle contraction (GO:0070472)3.18968948
81peptide catabolic process (GO:0043171)3.18954691
82cellular modified amino acid catabolic process (GO:0042219)3.18653904
83regulation of digestive system process (GO:0044058)3.18580861
84homeostasis of number of cells within a tissue (GO:0048873)3.18074205
85positive regulation of heat generation (GO:0031652)3.16137824
86endoplasmic reticulum unfolded protein response (GO:0030968)3.15621035
87growth hormone receptor signaling pathway (GO:0060396)3.15374270
88adhesion of symbiont to host (GO:0044406)3.13745575
89retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.13348858
90virion attachment to host cell (GO:0019062)3.13262129
91adhesion of symbiont to host cell (GO:0044650)3.13262129
92positive regulation of triglyceride metabolic process (GO:0090208)3.12154098
93negative regulation of lipid catabolic process (GO:0050995)3.12012407
94ovulation from ovarian follicle (GO:0001542)3.11821073
95notochord development (GO:0030903)3.11625146
96leukotriene metabolic process (GO:0006691)3.09517814
97positive regulation of p38MAPK cascade (GO:1900745)3.09506407
98glycerolipid catabolic process (GO:0046503)3.09171970
99positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.09124347
100negative regulation of bone remodeling (GO:0046851)3.08672643
101positive regulation of digestive system process (GO:0060456)3.06601119
102embryonic foregut morphogenesis (GO:0048617)3.06456149
103regulation of cholesterol storage (GO:0010885)3.06323200
104response to endoplasmic reticulum stress (GO:0034976)3.06222643
105triglyceride metabolic process (GO:0006641)3.05206984
106vesicle coating (GO:0006901)3.03742657
107atrial cardiac muscle cell action potential (GO:0086014)3.02599874
108long term synaptic depression (GO:0060292)3.02489505
109acute-phase response (GO:0006953)3.00193572
110citrulline metabolic process (GO:0000052)3.00151502
111negative regulation of granulocyte differentiation (GO:0030853)2.99775667
112cellular response to unfolded protein (GO:0034620)2.99537547
113proline biosynthetic process (GO:0006561)2.98903066
114negative regulation of macrophage differentiation (GO:0045650)2.98633964
115protein heterotrimerization (GO:0070208)2.98220417
116fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.97827902
117lipid particle organization (GO:0034389)2.97342266
118regulation of fever generation (GO:0031620)2.96136793
119response to zinc ion (GO:0010043)2.95452909
120biotin metabolic process (GO:0006768)2.93694051
121alpha-linolenic acid metabolic process (GO:0036109)2.93544089
122sulfation (GO:0051923)2.93290480
123glutathione biosynthetic process (GO:0006750)2.92805799
124acylglycerol metabolic process (GO:0006639)2.92324933
125DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.91994512
126endocardial cushion development (GO:0003197)2.91558135
127regulation of mononuclear cell migration (GO:0071675)2.91458045
128ER-nucleus signaling pathway (GO:0006984)2.90890205
129cellular response to epinephrine stimulus (GO:0071872)2.90603463
130renal system process involved in regulation of blood volume (GO:0001977)2.89903308
131regulation of metalloenzyme activity (GO:0048552)2.89610604
132complement activation, alternative pathway (GO:0006957)2.88416999
133neutral lipid metabolic process (GO:0006638)2.87034893
134positive regulation of cholesterol efflux (GO:0010875)2.85630629
135maintenance of gastrointestinal epithelium (GO:0030277)2.85469576
136regulation of lymphocyte chemotaxis (GO:1901623)2.85029320
137negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.84650671
138skeletal muscle organ development (GO:0060538)2.84642331
139endothelium development (GO:0003158)2.82741313
140regulation of pseudopodium assembly (GO:0031272)2.82552293
141negative regulation of leukocyte chemotaxis (GO:0002689)2.82042003
142negative regulation of actin filament depolymerization (GO:0030835)2.81092930
143negative regulation of smooth muscle cell proliferation (GO:0048662)2.80763688
144response to follicle-stimulating hormone (GO:0032354)2.78744138
145water-soluble vitamin metabolic process (GO:0006767)2.78079621
146negative regulation of cell size (GO:0045792)2.77747255
147cellular response to topologically incorrect protein (GO:0035967)2.77644216
148negative regulation of endothelial cell apoptotic process (GO:2000352)2.76520848
149activation of protein kinase B activity (GO:0032148)2.76367350
150positive regulation of calcium ion transport into cytosol (GO:0010524)2.75735391
151ventricular cardiac muscle cell action potential (GO:0086005)2.74625396
152UDP-N-acetylglucosamine metabolic process (GO:0006047)2.74119136
153eosinophil chemotaxis (GO:0048245)2.74072528
154negative regulation of smooth muscle cell migration (GO:0014912)2.73772217
155negative regulation of phagocytosis (GO:0050765)2.73671443
156regulation of chemokine-mediated signaling pathway (GO:0070099)2.73435588
157myelin maintenance (GO:0043217)2.73357787
158oxaloacetate metabolic process (GO:0006107)2.72970028
159regulation of translation in response to stress (GO:0043555)2.72794923
160retina vasculature morphogenesis in camera-type eye (GO:0061299)2.72750098
161cellular response to fluid shear stress (GO:0071498)2.70340298
162regulation of hormone metabolic process (GO:0032350)2.67974756
163CDP-diacylglycerol biosynthetic process (GO:0016024)2.67678791
164regulation of membrane protein ectodomain proteolysis (GO:0051043)2.67395028
165nonribosomal peptide biosynthetic process (GO:0019184)2.66303928
166negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.65505631
167triglyceride biosynthetic process (GO:0019432)2.65477896
168xenobiotic catabolic process (GO:0042178)2.64882305
169brown fat cell differentiation (GO:0050873)2.63713683
170positive regulation of smooth muscle cell migration (GO:0014911)2.60942068
171neutral lipid biosynthetic process (GO:0046460)2.60229396
172acylglycerol biosynthetic process (GO:0046463)2.60229396
173negative regulation of response to reactive oxygen species (GO:1901032)2.59415231
174regulation of hydrogen peroxide-induced cell death (GO:1903205)2.59248695
175positive regulation of metanephros development (GO:0072216)2.58595965
176regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.58463423
177polarized epithelial cell differentiation (GO:0030859)2.57957119
178negative regulation of tumor necrosis factor production (GO:0032720)2.55526831
179regulation of triglyceride metabolic process (GO:0090207)2.54417000
180fatty-acyl-CoA biosynthetic process (GO:0046949)2.52228741
181serine transport (GO:0032329)2.51346466
182hypotonic response (GO:0006971)2.50284070
183tetrapyrrole metabolic process (GO:0033013)2.50256581
184retinol metabolic process (GO:0042572)2.48849374
185positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.48116945
186regulation of heat generation (GO:0031650)2.46572235
187negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.46238734
188monocyte chemotaxis (GO:0002548)2.46152533
189CDP-diacylglycerol metabolic process (GO:0046341)2.46101746
190L-serine transport (GO:0015825)2.45799791
191intestinal cholesterol absorption (GO:0030299)13.4403465
192protein retention in ER lumen (GO:0006621)11.0932705
193maintenance of protein localization in endoplasmic reticulum (GO:0035437)10.0991122

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.18586405
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.69884899
3STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse4.60894307
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.11597586
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.45859615
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.84738424
7SCL_19346495_ChIP-Seq_HPC-7_Human2.69857873
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.68593066
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.64450891
10SOX2_27498859_Chip-Seq_STOMACH_Mouse2.55353366
11SALL4_18804426_ChIP-ChIP_XEN_Mouse2.30999316
12GATA4_25053715_ChIP-Seq_YYC3_Human2.28574848
13MYC_22102868_ChIP-Seq_BL_Human2.21055777
14HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.19359783
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.14659927
16GATA6_25053715_ChIP-Seq_YYC3_Human2.12135528
17TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.12052761
18PPARA_22158963_ChIP-Seq_LIVER_Mouse2.07755854
19RXR_22158963_ChIP-Seq_LIVER_Mouse2.05658136
20SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.02892302
21KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.00548441
22KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.00548441
23KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.00548441
24IKZF1_21737484_ChIP-ChIP_HCT116_Human1.78222639
25* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.76681793
26TCF7_22412390_ChIP-Seq_EML_Mouse1.76564960
27* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.76090627
28IRF8_21731497_ChIP-ChIP_J774_Mouse1.75017766
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.72887897
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.71558328
31SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.65841083
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.63602273
33IRF8_27001747_Chip-Seq_BMDM_Mouse1.62820386
34MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.61284894
35SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.60597887
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.59806654
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57597533
38FOXO3_23340844_ChIP-Seq_DLD1_Human1.56256603
39AR_21909140_ChIP-Seq_LNCAP_Human1.55227124
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.54331539
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.53185976
42KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49989509
43* LXR_22158963_ChIP-Seq_LIVER_Mouse1.49332376
44GATA2_21666600_ChIP-Seq_HMVEC_Human1.49174634
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.47827341
46KDM2B_26808549_Chip-Seq_DND41_Human1.46519513
47ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.44747663
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.44373396
49ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.42773324
50CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.42716649
51KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.42456263
52NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.39671423
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.39209380
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37935023
55AR_21572438_ChIP-Seq_LNCaP_Human1.35686185
56E2F7_22180533_ChIP-Seq_HELA_Human1.35578907
57Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.34091940
58PKCTHETA_26484144_Chip-Seq_BREAST_Human1.32224109
59GATA1_19941826_ChIP-Seq_K562_Human1.29767834
60FOXA2_19822575_ChIP-Seq_HepG2_Human1.26672330
61SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.26328592
62STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.25848645
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24993248
64ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23808824
65ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23579677
66TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22563747
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.21727933
68* NANOG_21062744_ChIP-ChIP_HESCs_Human1.21610247
69ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21463548
70LXR_22292898_ChIP-Seq_THP-1_Human1.21255861
71SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.20108220
72UTX_26944678_Chip-Seq_JUKART_Human1.20086194
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20060046
74CLOCK_20551151_ChIP-Seq_293T_Human1.19689380
75KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19587048
76TCF3_18692474_ChIP-Seq_MEFs_Mouse1.19406480
77RUNX1_27514584_Chip-Seq_MCF-7_Human1.18876075
78CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.18014415
79MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17865527
80STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17568606
81EED_16625203_ChIP-ChIP_MESCs_Mouse1.17451300
82ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16851471
83GATA1_19941827_ChIP-Seq_MEL_Mouse1.16791368
84IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16178565
85* CJUN_26792858_Chip-Seq_BT549_Human1.16019791
86STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15909163
87ELK3_25401928_ChIP-Seq_HUVEC_Human1.15738060
88BRD4_27068464_Chip-Seq_AML-cells_Mouse1.14812473
89SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14795729
90GATA3_24758297_ChIP-Seq_MCF-7_Human1.13948001
91SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.13393360
92CREB1_26743006_Chip-Seq_LNCaP_Human1.13345095
93CHD1_26751641_Chip-Seq_LNCaP_Human1.13071387
94PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.12879712
95FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.12515691
96EGR1_19032775_ChIP-ChIP_M12_Human1.11805285
97STAT1_20625510_ChIP-Seq_HELA_Human1.11348972
98FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.11179006
99FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.10466791
100RACK7_27058665_Chip-Seq_MCF-7_Human1.09240458
101EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.09103933
102TRIM28_21343339_ChIP-Seq_HEK293_Human1.07690644
103PPAR_26484153_Chip-Seq_NCI-H1993_Human1.07312184
104VDR_24763502_ChIP-Seq_THP-1_Human1.07309159
105LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06913272
106PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.05418634
107ATF3_27146783_Chip-Seq_COLON_Human1.05373543
108SOX2_20726797_ChIP-Seq_SW620_Human1.05316675
109MYB_26560356_Chip-Seq_TH2_Human1.05088640
110TP63_17297297_ChIP-ChIP_HaCaT_Human1.05024510
111SA1_27219007_Chip-Seq_Bcells_Human1.04355923
112SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.03352545
113KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03051904
114RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02828371
115PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02454815
116JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02410569
117CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.02321003
118VDR_24787735_ChIP-Seq_THP-1_Human1.01780122
119TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01777324
120RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01581147
121VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01233107
122FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.00948481
123CDX2_20551321_ChIP-Seq_CACO-2_Human1.00541695
124ESR1_20079471_ChIP-ChIP_T-47D_Human0.99838703
125NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99827340
126EP300_21415370_ChIP-Seq_HL-1_Mouse0.99639818
127JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99581084
128MAF_26560356_Chip-Seq_TH1_Human0.99200335
129SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98870221
130* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98806723
131TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.97942218
132NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.96795649
133RUNX_20019798_ChIP-Seq_JUKART_Human0.95653863
134TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95463716
135MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95055727
136TBX20_22328084_ChIP-Seq_HEART_Mouse0.95016546
137TBX20_22080862_ChIP-Seq_HEART_Mouse0.95016546
138EZH2_18974828_ChIP-Seq_MESCs_Mouse0.94767721
139RNF2_18974828_ChIP-Seq_MESCs_Mouse0.94767721
140ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.94764819
141ZFP281_18757296_ChIP-ChIP_E14_Mouse0.92673801
142* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.92335335
143SPI1_23127762_ChIP-Seq_K562_Human0.92331333
144SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.91987723
145NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91222068
146PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91021558
147* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.90916906
148PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89576423
149* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.88069734
150CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87795966
151DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87281431
152EZH2_27294783_Chip-Seq_ESCs_Mouse0.86733335
153ERA_21632823_ChIP-Seq_H3396_Human0.86620224
154BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86454621
155EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.86267251
156SMC1_22415368_ChIP-Seq_MEFs_Mouse0.85683243
157KDM2B_26808549_Chip-Seq_K562_Human0.84193099
158GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83275683
159* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.82552215
160NFIB_24661679_ChIP-Seq_LUNG_Mouse0.81959496
161SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.81914415
162CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.81245556
163PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.80775737
164CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80635546
165JARID2_20075857_ChIP-Seq_MESCs_Mouse0.80011953
166PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79471393
167UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.79456367
168TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.79258270

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract9.43876625
2MP0001666_abnormal_nutrient_absorption7.60090776
3MP0005365_abnormal_bile_salt5.27918124
4MP0008004_abnormal_stomach_pH4.35176083
5MP0003868_abnormal_feces_composition4.32946538
6MP0005085_abnormal_gallbladder_physiolo4.18388182
7MP0005084_abnormal_gallbladder_morpholo4.10055639
8MP0005670_abnormal_white_adipose3.67228035
9MP0002877_abnormal_melanocyte_morpholog3.23053268
10MP0003724_increased_susceptibility_to3.02637890
11MP0009840_abnormal_foam_cell2.88346985
12MP0003303_peritoneal_inflammation2.81626286
13MP0005666_abnormal_adipose_tissue2.74140272
14MP0005220_abnormal_exocrine_pancreas2.57210310
15MP0004858_abnormal_nervous_system2.50638369
16MP0002971_abnormal_brown_adipose2.47106425
17MP0005167_abnormal_blood-brain_barrier2.39696587
18MP0003806_abnormal_nucleotide_metabolis2.27003608
19MP0003011_delayed_dark_adaptation2.26106670
20MP0005623_abnormal_meninges_morphology2.24617843
21MP0002139_abnormal_hepatobiliary_system2.22608613
22MP0002876_abnormal_thyroid_physiology2.16751891
23MP0010234_abnormal_vibrissa_follicle2.04863636
24MP0001661_extended_life_span1.93206507
25MP0005451_abnormal_body_composition1.91216222
26MP0001664_abnormal_digestion1.88704970
27MP0002295_abnormal_pulmonary_circulatio1.87000666
28MP0009384_cardiac_valve_regurgitation1.86192005
29MP0005334_abnormal_fat_pad1.86029359
30MP0004264_abnormal_extraembryonic_tissu1.82544784
31MP0003705_abnormal_hypodermis_morpholog1.78166410
32MP0005375_adipose_tissue_phenotype1.78015604
33MP0002837_dystrophic_cardiac_calcinosis1.72366217
34MP0003959_abnormal_lean_body1.67683946
35MP0003436_decreased_susceptibility_to1.65802064
36MP0006138_congestive_heart_failure1.64780535
37MP0004130_abnormal_muscle_cell1.63938082
38MP0006054_spinal_hemorrhage1.63784481
39MP0003329_amyloid_beta_deposits1.59539065
40MP0005535_abnormal_body_temperature1.54569703
41MP0005647_abnormal_sex_gland1.48444252
42MP0003279_aneurysm1.47968410
43MP0002970_abnormal_white_adipose1.43966643
44MP0009115_abnormal_fat_cell1.43412368
45MP0003879_abnormal_hair_cell1.42519523
46MP0003075_altered_response_to1.41442054
47MP0001533_abnormal_skeleton_physiology1.39801043
48MP0003828_pulmonary_edema1.38300484
49MP0004883_abnormal_blood_vessel1.35442760
50MP0006082_CNS_inflammation1.33511856
51MP0005595_abnormal_vascular_smooth1.33438850
52MP0010352_gastrointestinal_tract_polyps1.27289694
53MP0009278_abnormal_bone_marrow1.25462289
54MP0010329_abnormal_lipoprotein_level1.22559432
55MP0002148_abnormal_hypersensitivity_rea1.22511836
56MP0002419_abnormal_innate_immunity1.22020755
57MP0000465_gastrointestinal_hemorrhage1.21449182
58MP0000749_muscle_degeneration1.21029926
59MP0003186_abnormal_redox_activity1.20352236
60MP0005410_abnormal_fertilization1.19620797
61MP0009785_altered_susceptibility_to1.17175131
62MP0002998_abnormal_bone_remodeling1.15293325
63MP0003690_abnormal_glial_cell1.13732700
64MP0004808_abnormal_hematopoietic_stem1.13624738
65MP0002254_reproductive_system_inflammat1.13412932
66MP0003300_gastrointestinal_ulcer1.13405510
67MP0003656_abnormal_erythrocyte_physiolo1.13071492
68MP0001501_abnormal_sleep_pattern1.12279794
69MP0010368_abnormal_lymphatic_system1.11702968
70MP0005310_abnormal_salivary_gland1.11404081
71MP0000490_abnormal_crypts_of1.10837896
72MP0000767_abnormal_smooth_muscle1.10441675
73MP0001915_intracranial_hemorrhage1.08897905
74MP0000470_abnormal_stomach_morphology1.08745876
75MP0002693_abnormal_pancreas_physiology1.08658808
76MP0004084_abnormal_cardiac_muscle1.03654237
77MP0003638_abnormal_response/metabolism_1.03406501
78MP0003566_abnormal_cell_adhesion1.02513520
79MP0004185_abnormal_adipocyte_glucose1.02052851
80MP0008770_decreased_survivor_rate1.01476906
81MP0002118_abnormal_lipid_homeostasis1.00891993
82MP0005025_abnormal_response_to1.00515956
83MP0005408_hypopigmentation0.98869210
84MP0010678_abnormal_skin_adnexa0.98614551
85MP0003453_abnormal_keratinocyte_physiol0.98543795
86MP0004233_abnormal_muscle_weight0.97307290
87MP0004272_abnormal_basement_membrane0.96228367
88MP0008469_abnormal_protein_level0.95815693
89MP0005397_hematopoietic_system_phenotyp0.93143569
90MP0001545_abnormal_hematopoietic_system0.93143569
91MP0000343_altered_response_to0.91852213
92MP0005000_abnormal_immune_tolerance0.90600933
93MP0005464_abnormal_platelet_physiology0.90261866
94MP0000604_amyloidosis0.88328601
95MP0000249_abnormal_blood_vessel0.87881489
96MP0002078_abnormal_glucose_homeostasis0.87715034
97MP0008961_abnormal_basal_metabolism0.87194739
98MP0003252_abnormal_bile_duct0.85256425
99MP0002132_abnormal_respiratory_system0.84758621
100MP0005452_abnormal_adipose_tissue0.84397719
101MP0009333_abnormal_splenocyte_physiolog0.84047039
102MP0005058_abnormal_lysosome_morphology0.83740827
103MP0005584_abnormal_enzyme/coenzyme_acti0.83596758
104MP0004947_skin_inflammation0.81758856
105MP0002405_respiratory_system_inflammati0.80218803
106MP0000598_abnormal_liver_morphology0.79775655
107MP0001485_abnormal_pinna_reflex0.78661775
108MP0005332_abnormal_amino_acid0.77393310
109MP0001853_heart_inflammation0.76410829
110MP0010155_abnormal_intestine_physiology0.76110212
111MP0004147_increased_porphyrin_level0.75496694
112MP0001756_abnormal_urination0.75352440
113MP0001542_abnormal_bone_strength0.74537018
114MP0009765_abnormal_xenobiotic_induced0.72868421
115MP0005448_abnormal_energy_balance0.72771837
116MP0005275_abnormal_skin_tensile0.71989062
117MP0005390_skeleton_phenotype0.71677685
118MP0002638_abnormal_pupillary_reflex0.71548921
119MP0004019_abnormal_vitamin_homeostasis0.70283660
120MP0000383_abnormal_hair_follicle0.70011363
121MP0004036_abnormal_muscle_relaxation0.69436418
122MP0003941_abnormal_skin_development0.68973971
123MP0000230_abnormal_systemic_arterial0.66666548
124MP0000751_myopathy0.66555491
125MP0003221_abnormal_cardiomyocyte_apopto0.66209804
126MP0006036_abnormal_mitochondrial_physio0.65357716
127MP0005164_abnormal_response_to0.61793499
128MP0001944_abnormal_pancreas_morphology0.60397708
129MP0004957_abnormal_blastocyst_morpholog0.59734286
130MP0001873_stomach_inflammation0.57809699
131MP0005165_increased_susceptibility_to0.57715001
132MP0000609_abnormal_liver_physiology0.56979899
133MP0004510_myositis0.56495916
134MP0004885_abnormal_endolymph0.54912163
135MP0003943_abnormal_hepatobiliary_system0.54014211
136MP0002086_abnormal_extraembryonic_tissu0.53842787
137MP0001790_abnormal_immune_system0.51445451
138MP0005387_immune_system_phenotype0.51445451
139MP0008438_abnormal_cutaneous_collagen0.50921613
140MP0003795_abnormal_bone_structure0.50892430
141MP0001845_abnormal_inflammatory_respons0.49339716
142MP0001663_abnormal_digestive_system0.49144013
143MP0001849_ear_inflammation0.45561171
144MP0005174_abnormal_tail_pigmentation0.45473236
145MP0005671_abnormal_response_to0.45273961
146MP0003866_abnormal_defecation0.45118894
147MP0008873_increased_physiological_sensi0.44411240
148MP0009763_increased_sensitivity_to0.43599683
149MP0010307_abnormal_tumor_latency0.43076220
150MP0003172_abnormal_lysosome_physiology0.42584207
151MP0002138_abnormal_hepatobiliary_system0.41920431
152MP0003448_altered_tumor_morphology0.41392056
153MP0003984_embryonic_growth_retardation0.40059372
154MP0004134_abnormal_chest_morphology0.39557073
155MP0001697_abnormal_embryo_size0.38728535
156MP0002269_muscular_atrophy0.38457428
157MP0009643_abnormal_urine_homeostasis0.37724260
158MP0003953_abnormal_hormone_level0.36802783
159MP0005380_embryogenesis_phenotype0.36700801
160MP0001672_abnormal_embryogenesis/_devel0.36700801
161MP0001851_eye_inflammation0.36597649
162MP0002928_abnormal_bile_duct0.36456763
163MP0005319_abnormal_enzyme/_coenzyme0.36368141
164MP0003119_abnormal_digestive_system0.35919159

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)6.54008236
2Gout (HP:0001997)6.41626208
3Abnormality of cells of the erythroid lineage (HP:0012130)6.20556820
4Increased mean platelet volume (HP:0011877)5.49425363
5Petechiae (HP:0000967)5.39278659
6Abnormal platelet volume (HP:0011876)5.01875147
7Menorrhagia (HP:0000132)4.56878027
8Ventricular fibrillation (HP:0001663)4.50383537
9Right ventricular cardiomyopathy (HP:0011663)4.48150251
10Axonal loss (HP:0003447)4.47557321
11Systemic lupus erythematosus (HP:0002725)4.30701843
12Congenital sensorineural hearing impairment (HP:0008527)4.24383699
13Cortical dysplasia (HP:0002539)4.15802173
14Hypertriglyceridemia (HP:0002155)4.09140745
15Abnormality of oral frenula (HP:0000190)4.08547691
16Abnormal pancreas size (HP:0012094)4.03431125
17Purpura (HP:0000979)4.02617179
18Complement deficiency (HP:0004431)3.95888041
19Megaloblastic anemia (HP:0001889)3.82482421
20Abnormality of liposaccharide metabolism (HP:0010968)3.77220799
21Abnormality of glycosphingolipid metabolism (HP:0004343)3.77220799
22Abnormality of glycolipid metabolism (HP:0010969)3.77220799
23Carpal bone hypoplasia (HP:0001498)3.69397431
24Difficulty running (HP:0009046)3.65616927
25Glomerulonephritis (HP:0000099)3.60498206
26Acanthosis nigricans (HP:0000956)3.59005363
27Gingival bleeding (HP:0000225)3.52222451
28Nuclear cataract (HP:0100018)3.51809153
29Increased serum pyruvate (HP:0003542)3.48367052
30Increased purine levels (HP:0004368)3.35249726
31Hyperuricemia (HP:0002149)3.35249726
32Steatorrhea (HP:0002570)3.33326181
33Abnormal tarsal ossification (HP:0008369)3.31186270
34Fat malabsorption (HP:0002630)3.29997993
35Impaired platelet aggregation (HP:0003540)3.25437593
36Abnormal platelet function (HP:0011869)3.25437593
37Aplasia of the musculature (HP:0100854)3.23424987
38Hypoproteinemia (HP:0003075)3.22835271
39Abnormality of complement system (HP:0005339)3.15569635
40Mutism (HP:0002300)3.12538267
41Muscle fiber splitting (HP:0003555)3.10523649
42Fetal akinesia sequence (HP:0001989)3.09493378
43Tubulointerstitial nephritis (HP:0001970)3.04386138
44Premature skin wrinkling (HP:0100678)3.03275564
45Loss of speech (HP:0002371)3.00955479
46Oligomenorrhea (HP:0000876)3.00512149
47Diaphragmatic weakness (HP:0009113)2.98875378
48Tubulointerstitial fibrosis (HP:0005576)2.97439040
49Abnormality of glycolysis (HP:0004366)2.93166989
50Hyperglycinemia (HP:0002154)2.89778337
51Abnormality of endocrine pancreas physiology (HP:0012093)2.87270322
52Abnormality of the pancreatic islet cells (HP:0006476)2.87270322
53Spontaneous hematomas (HP:0007420)2.87170014
54Resting tremor (HP:0002322)2.85810490
55Abnormality of the vitamin B12 metabolism (HP:0004341)2.83143778
56Abnormality of vitamin B metabolism (HP:0004340)2.81457351
57Disinhibition (HP:0000734)2.80644223
58Vacuolated lymphocytes (HP:0001922)2.80101535
59Bone cyst (HP:0012062)2.77772824
60Dysostosis multiplex (HP:0000943)2.77729336
61Small epiphyses (HP:0010585)2.77164108
62Prolonged bleeding time (HP:0003010)2.72810623
63Ankyloglossia (HP:0010296)2.72412156
64Abnormality of the periventricular white matter (HP:0002518)2.71233377
65Polyphagia (HP:0002591)2.66749901
66Hypoplasia of the odontoid process (HP:0003311)2.66193297
67Goiter (HP:0000853)2.57833716
68Insulin-resistant diabetes mellitus (HP:0000831)2.55545404
69Exocrine pancreatic insufficiency (HP:0001738)2.52932894
70Abnormal foot bone ossification (HP:0010675)2.52387851
71Obstructive sleep apnea (HP:0002870)2.48578528
72Gonadal dysgenesis (HP:0000133)2.47104656
73Esophageal neoplasm (HP:0100751)2.46286454
74Neoplasm of head and neck (HP:0012288)2.46286454
75Abnormality of vitamin metabolism (HP:0100508)2.45301536
76Insulin resistance (HP:0000855)2.42153337
77Increased CSF protein (HP:0002922)2.40814493
78Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.40267717
79Cervical subluxation (HP:0003308)2.39296426
80Rough bone trabeculation (HP:0100670)2.35343239
81Abnormality of the renal cortex (HP:0011035)2.35197384
82Abnormality of alanine metabolism (HP:0010916)2.34812560
83Hyperalaninemia (HP:0003348)2.34812560
84Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.34812560
85Hypoplasia of the pons (HP:0012110)2.34475994
86Abnormality of polysaccharide metabolism (HP:0011012)2.34349130
87Abnormality of glycosaminoglycan metabolism (HP:0004371)2.34349130
88Abnormality of mucopolysaccharide metabolism (HP:0011020)2.34349130
89Large hands (HP:0001176)2.33329159
90Abnormality of purine metabolism (HP:0004352)2.32817777
91Hyperglycinuria (HP:0003108)2.32794907
92Stridor (HP:0010307)2.31332286
93Increased muscle lipid content (HP:0009058)2.29484658
94Increased variability in muscle fiber diameter (HP:0003557)2.29177829
95Retinal atrophy (HP:0001105)2.29175444
96Abnormal trabecular bone morphology (HP:0100671)2.28205677
97Hydroxyprolinuria (HP:0003080)2.27152040
98Abnormality of proline metabolism (HP:0010907)2.27152040
99Tubular atrophy (HP:0000092)2.25760582
100Abnormality of macrophages (HP:0004311)2.23661077
101Growth hormone excess (HP:0000845)2.22617322
102Intrahepatic cholestasis (HP:0001406)2.22266666
103Renal salt wasting (HP:0000127)2.20333217
104Recurrent gram-negative bacterial infections (HP:0005420)2.18756315
105Nephritis (HP:0000123)2.18516931
106Distal lower limb muscle weakness (HP:0009053)2.17695034
107Apathy (HP:0000741)2.17643076
108Malnutrition (HP:0004395)2.17440151
109Easy fatigability (HP:0003388)2.15342745
110Severe short stature (HP:0003510)2.13851720
111Abnormality of the intrinsic pathway (HP:0010989)2.13140804
112Abnormality of the pleura (HP:0002103)2.13012722
113Limb hypertonia (HP:0002509)2.11059464
114Patent foramen ovale (HP:0001655)2.10509697
115Gowers sign (HP:0003391)2.09460088
116Abnormality of the pons (HP:0007361)2.08525865
117Amyloidosis (HP:0011034)2.07935540
118Abnormality of the odontoid process (HP:0003310)2.07382858
119Recurrent abscess formation (HP:0002722)2.06812033
120Abnormality of glycine metabolism (HP:0010895)2.05350084
121Abnormality of serine family amino acid metabolism (HP:0010894)2.05350084
122Testicular neoplasm (HP:0010788)2.04747197
123Xanthomatosis (HP:0000991)2.04422503
124Diminished motivation (HP:0000745)2.03416470
125Hemorrhage of the eye (HP:0011885)2.02174338
126Increased neuronal autofluorescent lipopigment (HP:0002074)2.01788677
127Barrel-shaped chest (HP:0001552)2.01456081
128Spinal muscular atrophy (HP:0007269)1.99714475
129Myocardial infarction (HP:0001658)1.99484993
130Ventricular arrhythmia (HP:0004308)1.98860553
131Neoplasm of the peripheral nervous system (HP:0100007)1.98836875
132Scapular winging (HP:0003691)1.97818695
133Bulbar palsy (HP:0001283)1.97718572
134Prolonged neonatal jaundice (HP:0006579)1.95550565
135Conjugated hyperbilirubinemia (HP:0002908)1.94333952
136Infantile muscular hypotonia (HP:0008947)1.94258356
137Sudden cardiac death (HP:0001645)1.94151304
138Tetraplegia (HP:0002445)1.93676940
139Abnormality of the common coagulation pathway (HP:0010990)1.93513595
140Syncope (HP:0001279)1.91336074
141Hyperlipoproteinemia (HP:0010980)1.91212976
142Nausea (HP:0002018)1.90099726
143Heterochromia iridis (HP:0001100)1.89700348
144Joint hemorrhage (HP:0005261)1.89317531
145Vertebral compression fractures (HP:0002953)1.88738191
146Osteolytic defects of the hand bones (HP:0009699)1.88200437
147Osteolytic defects of the phalanges of the hand (HP:0009771)1.88200437
148Abnormality of aromatic amino acid family metabolism (HP:0004338)1.88073466
149Rhabdomyolysis (HP:0003201)1.88005961
150Increased cerebral lipofuscin (HP:0011813)1.86548133
151Glomerulosclerosis (HP:0000096)1.86337098
152Flat acetabular roof (HP:0003180)1.86230787
153Aplastic anemia (HP:0001915)1.85845050
154Enlarged penis (HP:0000040)1.85125834
155Limb-girdle muscle atrophy (HP:0003797)1.85118835
156Deep venous thrombosis (HP:0002625)1.84510751
157Macroorchidism (HP:0000053)1.84234554
158Distal upper limb amyotrophy (HP:0007149)1.84202584
159Upper limb amyotrophy (HP:0009129)1.84202584
160Urinary glycosaminoglycan excretion (HP:0003541)1.83997951
161Mucopolysacchariduria (HP:0008155)1.83997951
162Peripheral demyelination (HP:0011096)1.83836084
163Long foot (HP:0001833)1.83686676
164Ketoacidosis (HP:0001993)1.83095921
165Cerebral aneurysm (HP:0004944)1.82195410
166Ketosis (HP:0001946)1.81870642
167Abnormality of sulfur amino acid metabolism (HP:0004339)1.81813618
168Macrocytic anemia (HP:0001972)1.81346681
169Abnormality of the alveolar ridges (HP:0006477)1.77444712
170Cerebellar dysplasia (HP:0007033)1.77326633
171Epiphyseal dysplasia (HP:0002656)1.77017896
172Bilateral sensorineural hearing impairment (HP:0008619)1.74856005
173Fibroma (HP:0010614)1.74547548
174Prolonged QT interval (HP:0001657)1.74295544
175Autoamputation (HP:0001218)1.73796283
176Periodontitis (HP:0000704)1.71461442
177Shallow orbits (HP:0000586)1.71014606
178Pancreatitis (HP:0001733)1.70515798
179Hemiplegia (HP:0002301)1.70307963
180Flattened epiphyses (HP:0003071)1.68526982
181Germ cell neoplasia (HP:0100728)1.68171551
182Polygenic inheritance (HP:0010982)1.67272265

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K5.62075272
2BCKDK4.71180064
3EIF2AK34.00591520
4IRAK33.94424652
5FRK3.64832762
6TAOK33.61035727
7PINK13.44244666
8TRIB33.20599027
9MAPKAPK32.97464558
10MATK2.93693640
11CAMK1D2.69904253
12LATS12.41851206
13EPHA32.38028354
14TGFBR22.17115242
15ZAP702.11905312
16KIT2.09462290
17PKN22.08931823
18BLK1.96467916
19NME11.95637219
20SCYL21.92749554
21PRKAA21.90582424
22DDR21.88588919
23TAOK21.81516369
24RIPK11.80553510
25CLK11.72663758
26RPS6KB21.69935276
27CAMK1G1.68621135
28PRPF4B1.68448989
29LRRK21.67412529
30OBSCN1.66409678
31TIE11.63604389
32CDK121.61409089
33EPHB21.57766261
34TRPM71.55835925
35CAMKK21.55578976
36MOS1.51661274
37STK241.48732312
38TBK11.47183404
39MUSK1.46769083
40MAP4K11.43734325
41PIM21.42553933
42PDK21.37899848
43SIK11.37785604
44ERN11.33117212
45MAPK71.29223497
46CDK61.28808982
47FGR1.18832634
48ABL21.18453285
49PDGFRB1.18318272
50MAP3K131.17707969
51CDK41.13033558
52TYK21.12452395
53TESK21.11783204
54LATS21.11014399
55MYLK1.10984363
56MAP3K31.07468759
57MARK31.06939397
58IKBKB1.06586023
59MAPK151.05729745
60FGFR21.03754727
61KSR21.03365966
62MAP2K21.02594345
63MAPKAPK51.00188977
64WNK40.99324872
65MAP3K70.98868386
66MAP3K10.97228470
67JAK30.97106553
68ADRBK20.96922916
69STK100.95360841
70RET0.95229029
71MAP2K10.95048361
72AKT30.91716082
73CAMK10.90004139
74GSK3A0.88877893
75MAPK40.88705943
76JAK20.87579008
77PIK3CA0.85286072
78FES0.85272112
79ARAF0.81749931
80PTK60.80712284
81NLK0.78989993
82MTOR0.77383713
83GRK70.77247880
84MAP3K90.77178187
85PIM10.75267241
86MAP3K20.73751866
87ADRBK10.73292891
88TYRO30.72671764
89NTRK20.72554854
90PRKAA10.71755719
91PRKG20.68049039
92MAPK110.65063404
93IKBKE0.64871478
94PRKD20.63719295
95STK30.63280939
96FGFR30.61662866
97LIMK10.59036197
98TESK10.58591619
99MAPKAPK20.58052536
100INSRR0.57273110
101MAP3K80.57268468
102BMX0.56787394
103STK390.55085799
104CSNK1A1L0.54726952
105PRKACB0.53466791
106MAP3K140.52661940
107RIPK40.52175785
108PRKCD0.51717313
109ERBB40.50362854
110PRKACG0.50299908
111CDC42BPA0.50033136
112ILK0.49972245
113JAK10.47644762
114STK38L0.47469910
115WNK10.46602851
116NME20.46040659
117RPS6KA10.44712107
118PDK30.44708129
119PDK40.44708129
120PTK20.44272916
121PDGFRA0.42355534
122PRKG10.41795005
123DAPK30.41793811
124ITK0.41682477
125FGFR40.39332513
126IRAK40.38903136
127PAK20.38813640
128PRKCH0.38686229
129CSNK1G30.38434319
130IRAK10.37629319
131FER0.37578593
132MAP2K40.37392293
133CDK90.36713040
134CAMKK10.36006779
135TAOK10.35728833
136MAP3K60.35677490
137PDPK10.35493401
138SGK30.35029459
139CSNK1G20.34930419
140TNIK0.33776290
141DYRK1B0.33769962
142CSNK1G10.33187636
143PIK3CG0.32830312
144NTRK10.32025450
145DYRK30.32004725
146ALK0.31916294
147IGF1R0.31747954
148NEK60.31437988
149RPS6KA50.31374275
150CHUK0.30736590
151LYN0.29639526
152MAP3K50.28694091
153KDR0.27867999
154RPS6KA20.27563423
155TXK0.27366281
156PRKD10.27093319
157EPHB10.24749815
158NEK90.24707795
159PDK10.23814724
160CSK0.23730131
161MELK0.23245103
162MAPK120.22293708
163PRKCI0.21312325
164MAPK10.21066348
165ICK0.20441972
166GRK60.20176278
167RPS6KB10.19698056

Predicted pathways (KEGG)

RankGene SetZ-score
1Pancreatic secretion_Homo sapiens_hsa049727.48256264
2Fat digestion and absorption_Homo sapiens_hsa049755.31795515
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005334.22805666
4Fatty acid biosynthesis_Homo sapiens_hsa000613.73612431
5* Protein digestion and absorption_Homo sapiens_hsa049743.70448155
6Renin-angiotensin system_Homo sapiens_hsa046143.66240422
7Regulation of lipolysis in adipocytes_Homo sapiens_hsa049233.07198183
8Vitamin digestion and absorption_Homo sapiens_hsa049772.91764221
9Glycerolipid metabolism_Homo sapiens_hsa005612.53402072
10Mineral absorption_Homo sapiens_hsa049782.51800820
11PPAR signaling pathway_Homo sapiens_hsa033202.25503237
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.21114317
13Staphylococcus aureus infection_Homo sapiens_hsa051501.89023375
14Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.88835297
15Carbohydrate digestion and absorption_Homo sapiens_hsa049731.86397467
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.85713697
17Malaria_Homo sapiens_hsa051441.78550121
18Collecting duct acid secretion_Homo sapiens_hsa049661.72824412
19Folate biosynthesis_Homo sapiens_hsa007901.68031353
20Propanoate metabolism_Homo sapiens_hsa006401.64677054
21Starch and sucrose metabolism_Homo sapiens_hsa005001.57685724
22Steroid biosynthesis_Homo sapiens_hsa001001.55290699
23Sulfur relay system_Homo sapiens_hsa041221.52634646
24Osteoclast differentiation_Homo sapiens_hsa043801.51292132
25Nitrogen metabolism_Homo sapiens_hsa009101.42445651
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.37221505
27Protein export_Homo sapiens_hsa030601.29611133
28Vibrio cholerae infection_Homo sapiens_hsa051101.24869375
29Legionellosis_Homo sapiens_hsa051341.22980775
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.22830633
31Sulfur metabolism_Homo sapiens_hsa009201.21386565
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18077855
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17526521
34TNF signaling pathway_Homo sapiens_hsa046681.16338534
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.16204928
36Adipocytokine signaling pathway_Homo sapiens_hsa049201.14781797
37Pertussis_Homo sapiens_hsa051331.08456191
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06913139
39Fatty acid elongation_Homo sapiens_hsa000621.05712131
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.01180333
41Toxoplasmosis_Homo sapiens_hsa051450.99417738
42Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96770388
43Rheumatoid arthritis_Homo sapiens_hsa053230.96758423
44Fatty acid degradation_Homo sapiens_hsa000710.95655483
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94097923
46Small cell lung cancer_Homo sapiens_hsa052220.91145948
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90833968
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90533841
49One carbon pool by folate_Homo sapiens_hsa006700.90472083
50Influenza A_Homo sapiens_hsa051640.89182130
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89135390
52N-Glycan biosynthesis_Homo sapiens_hsa005100.88927217
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87740198
54Toll-like receptor signaling pathway_Homo sapiens_hsa046200.86910488
55Platelet activation_Homo sapiens_hsa046110.86668788
56Hepatitis C_Homo sapiens_hsa051600.86243224
57Other glycan degradation_Homo sapiens_hsa005110.85940553
58Ovarian steroidogenesis_Homo sapiens_hsa049130.85772833
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85709282
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85370390
61African trypanosomiasis_Homo sapiens_hsa051430.84663108
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82323249
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80098621
64Salmonella infection_Homo sapiens_hsa051320.78758245
65Linoleic acid metabolism_Homo sapiens_hsa005910.78128938
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78048514
67Histidine metabolism_Homo sapiens_hsa003400.77192333
68Biosynthesis of amino acids_Homo sapiens_hsa012300.76654862
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76596117
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.75814916
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.75221409
72Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75017274
73mTOR signaling pathway_Homo sapiens_hsa041500.72050228
74Leishmaniasis_Homo sapiens_hsa051400.71934914
75Gastric acid secretion_Homo sapiens_hsa049710.70773324
76Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69519931
77Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67841759
78VEGF signaling pathway_Homo sapiens_hsa043700.67187657
79Arachidonic acid metabolism_Homo sapiens_hsa005900.66576503
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66548894
81Lysine degradation_Homo sapiens_hsa003100.65434189
82Complement and coagulation cascades_Homo sapiens_hsa046100.59965224
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.59816272
84Type II diabetes mellitus_Homo sapiens_hsa049300.59810817
85Pancreatic cancer_Homo sapiens_hsa052120.59627382
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.55818479
87ECM-receptor interaction_Homo sapiens_hsa045120.55813871
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55691298
89Endometrial cancer_Homo sapiens_hsa052130.53564443
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53361569
91Apoptosis_Homo sapiens_hsa042100.53053095
92Chemical carcinogenesis_Homo sapiens_hsa052040.52665969
93Phenylalanine metabolism_Homo sapiens_hsa003600.52392873
94Fatty acid metabolism_Homo sapiens_hsa012120.49882420
95Prion diseases_Homo sapiens_hsa050200.49486265
96Tyrosine metabolism_Homo sapiens_hsa003500.49325434
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49017654
98Colorectal cancer_Homo sapiens_hsa052100.48466788
99Adherens junction_Homo sapiens_hsa045200.48185092
100Phagosome_Homo sapiens_hsa041450.47967639
101Arginine biosynthesis_Homo sapiens_hsa002200.47797659
102Insulin secretion_Homo sapiens_hsa049110.47636986
103Retinol metabolism_Homo sapiens_hsa008300.47155645
104Tuberculosis_Homo sapiens_hsa051520.47056291
105Tryptophan metabolism_Homo sapiens_hsa003800.46760106
106Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46182908
107Non-small cell lung cancer_Homo sapiens_hsa052230.45578324
108Notch signaling pathway_Homo sapiens_hsa043300.45219485
109Insulin resistance_Homo sapiens_hsa049310.44885091
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44384515
111Hematopoietic cell lineage_Homo sapiens_hsa046400.44076838
112Inositol phosphate metabolism_Homo sapiens_hsa005620.43386968
113p53 signaling pathway_Homo sapiens_hsa041150.42930617
114NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42769851
115Insulin signaling pathway_Homo sapiens_hsa049100.42551780
116AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41513366
117Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.39879506
118Peroxisome_Homo sapiens_hsa041460.39127855
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.38953339
120B cell receptor signaling pathway_Homo sapiens_hsa046620.38492257
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.38297515
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37698530
123Carbon metabolism_Homo sapiens_hsa012000.37628261
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37094089
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36905959
126Fructose and mannose metabolism_Homo sapiens_hsa000510.36385402
127AMPK signaling pathway_Homo sapiens_hsa041520.35829722
128Cholinergic synapse_Homo sapiens_hsa047250.34347116
129Arginine and proline metabolism_Homo sapiens_hsa003300.34163874
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33827085
131Estrogen signaling pathway_Homo sapiens_hsa049150.33070168
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32944329
133Hepatitis B_Homo sapiens_hsa051610.32766419
134Endocytosis_Homo sapiens_hsa041440.32679164
135Chronic myeloid leukemia_Homo sapiens_hsa052200.32463789
136Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32075866
137Focal adhesion_Homo sapiens_hsa045100.31022124
138Neurotrophin signaling pathway_Homo sapiens_hsa047220.30679672
139Rap1 signaling pathway_Homo sapiens_hsa040150.30171902
140Galactose metabolism_Homo sapiens_hsa000520.29819545
141Amoebiasis_Homo sapiens_hsa051460.29687817
142Pentose phosphate pathway_Homo sapiens_hsa000300.28815306
143Dilated cardiomyopathy_Homo sapiens_hsa054140.28302449
144Butanoate metabolism_Homo sapiens_hsa006500.27592980
145Phospholipase D signaling pathway_Homo sapiens_hsa040720.27201312
146Glioma_Homo sapiens_hsa052140.27078352
147Prostate cancer_Homo sapiens_hsa052150.26273731
148Pyruvate metabolism_Homo sapiens_hsa006200.24877894
149Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.24801442
150Bile secretion_Homo sapiens_hsa049760.24247005
151Leukocyte transendothelial migration_Homo sapiens_hsa046700.24119407
152Ether lipid metabolism_Homo sapiens_hsa005650.23807356
153Viral carcinogenesis_Homo sapiens_hsa052030.23313947
154Thyroid hormone synthesis_Homo sapiens_hsa049180.22704329
155beta-Alanine metabolism_Homo sapiens_hsa004100.20290820
156PI3K-Akt signaling pathway_Homo sapiens_hsa041510.19898731
157Glutathione metabolism_Homo sapiens_hsa004800.19851188
158Lysosome_Homo sapiens_hsa041420.19222116
159Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.18137078
160Primary bile acid biosynthesis_Homo sapiens_hsa001200.17903201
161Aldosterone synthesis and secretion_Homo sapiens_hsa049250.17743561
162Tight junction_Homo sapiens_hsa045300.17742371

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