ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	histone H2A acetylation (GO:0043968)	9.17083399
2	regulation of natural killer cell differentiation (GO:0032823)	8.29986052
3	positive regulation of natural killer cell differentiation (GO:0032825)	8.16271591
4	positive regulation of interleukin-17 production (GO:0032740)	7.35805432
5	positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)	6.63096211
6	phosphate ion transport (GO:0006817)	6.15316147
7	regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)	5.45035250
8	peptidyl-tyrosine autophosphorylation (GO:0038083)	4.96535869
9	response to mercury ion (GO:0046689)	4.78906386
10	urate metabolic process (GO:0046415)	4.52140660
11	positive regulation of uterine smooth muscle contraction (GO:0070474)	4.51138634
12	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	4.49051373
13	positive regulation of interferon-gamma biosynthetic process (GO:0045078)	4.45712464
14	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)	4.37273876
15	response to parathyroid hormone (GO:0071107)	4.35741042
16	positive regulation of natural killer cell mediated immunity (GO:0002717)	4.35363958
17	phosphate ion transmembrane transport (GO:0035435)	4.26594692
18	positive regulation of interleukin-10 production (GO:0032733)	3.98426155
19	regulation of natural killer cell activation (GO:0032814)	3.97981737
20	cytokine production involved in immune response (GO:0002367)	3.95591564
21	hyperosmotic salinity response (GO:0042538)	3.95511982
22	negative regulation of heart rate (GO:0010459)	3.95495519
23	DNA deamination (GO:0045006)	3.94327258
24	behavioral response to nicotine (GO:0035095)	3.88753082
25	methionine biosynthetic process (GO:0009086)	3.69085632
26	spliceosomal snRNP assembly (GO:0000387)	3.66581098
27	regulation of interleukin-17 production (GO:0032660)	3.61551084
28	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.58836153
29	positive regulation of natural killer cell activation (GO:0032816)	3.58634222
30	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.55209022
31	aminoglycoside antibiotic metabolic process (GO:0030647)	3.51783432
32	tricarboxylic acid metabolic process (GO:0072350)	3.50013795
33	L-methionine salvage (GO:0071267)	3.47804607
34	L-methionine biosynthetic process (GO:0071265)	3.47804607
35	amino acid salvage (GO:0043102)	3.47804607
36	positive regulation of mitochondrial fission (GO:0090141)	3.40454241
37	regulation of chronic inflammatory response (GO:0002676)	3.40130820
38	positive regulation of activated T cell proliferation (GO:0042104)	3.39300553
39	tachykinin receptor signaling pathway (GO:0007217)	3.36934618
40	regulation of uterine smooth muscle contraction (GO:0070472)	3.16205994
41	methionine metabolic process (GO:0006555)	3.09975558
42	regulation of interferon-gamma biosynthetic process (GO:0045072)	3.08162243
43	pseudouridine synthesis (GO:0001522)	3.07495646
44	protein neddylation (GO:0045116)	3.07274542
45	regulation of catecholamine metabolic process (GO:0042069)	3.07112151
46	regulation of dopamine metabolic process (GO:0042053)	3.07112151
47	energy homeostasis (GO:0097009)	3.06738899
48	regulation of isotype switching to IgG isotypes (GO:0048302)	3.05408858
49	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.00316694
50	regulation of interleukin-10 production (GO:0032653)	2.99999636
51	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.99832972
52	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.99832972
53	positive regulation of T cell differentiation in thymus (GO:0033089)	2.98196259
54	regulation of RNA export from nucleus (GO:0046831)	2.96397400
55	aspartate family amino acid biosynthetic process (GO:0009067)	2.95917307
56	inner mitochondrial membrane organization (GO:0007007)	2.92992584
57	cellular response to interleukin-15 (GO:0071350)	2.89359165
58	sulfur amino acid biosynthetic process (GO:0000097)	2.87974515
59	maturation of 5.8S rRNA (GO:0000460)	2.87735064
60	peroxisome fission (GO:0016559)	2.86889822
61	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.86539306
62	proteasome assembly (GO:0043248)	2.85824985
63	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.85168813
64	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	2.83391699
65	regulation of natural killer cell mediated immunity (GO:0002715)	2.83391699
66	production of molecular mediator of immune response (GO:0002440)	2.81584792
67	pentose metabolic process (GO:0019321)	2.79967800
68	purine nucleobase biosynthetic process (GO:0009113)	2.79896907
69	mitochondrial RNA metabolic process (GO:0000959)	2.79032537
70	neuronal stem cell maintenance (GO:0097150)	2.78662823
71	hematopoietic stem cell proliferation (GO:0071425)	2.74703492
72	spliceosomal tri-snRNP complex assembly (GO:0000244)	2.74222087
73	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.69955468
74	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.69955468
75	peptidyl-arginine omega-N-methylation (GO:0035247)	2.69457788
76	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.65887374
77	T cell lineage commitment (GO:0002360)	2.64864712
78	transmission of nerve impulse (GO:0019226)	2.63878039
79	hair cycle (GO:0042633)	2.60714028
80	molting cycle (GO:0042303)	2.60714028
81	regulation of proton transport (GO:0010155)	2.60308636
82	Peyers patch development (GO:0048541)	2.59266082
83	mucosal-associated lymphoid tissue development (GO:0048537)	2.59266082
84	histone mRNA metabolic process (GO:0008334)	2.57845658
85	viral mRNA export from host cell nucleus (GO:0046784)	2.56622878
86	organ growth (GO:0035265)	2.55604574
87	positive regulation of heart rate (GO:0010460)	2.54997566
88	synaptic transmission, cholinergic (GO:0007271)	2.54574768
89	negative regulation of alpha-beta T cell differentiation (GO:0046639)	2.53908719
90	positive regulation of smooth muscle contraction (GO:0045987)	2.52316750
91	ribosome assembly (GO:0042255)	2.50904998
92	L-fucose catabolic process (GO:0042355)	2.50493369
93	fucose catabolic process (GO:0019317)	2.50493369
94	L-fucose metabolic process (GO:0042354)	2.50493369
95	regulation of G0 to G1 transition (GO:0070316)	2.50458163
96	iron-sulfur cluster assembly (GO:0016226)	2.49869794
97	metallo-sulfur cluster assembly (GO:0031163)	2.49869794
98	cardiac right ventricle morphogenesis (GO:0003215)	2.49380107
99	phasic smooth muscle contraction (GO:0014821)	2.48714812
100	response to interleukin-15 (GO:0070672)	2.48711631

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	6.11335135
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.28906591
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.33638719
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.32726831
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.05843211
6	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.05306560
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.63107158
8	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.60313001
9	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.60222729
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.53356944
11	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.43828124
12	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.41492237
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.35205551
14	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.34399378
15	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.11375459
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.06584442
17	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.04378378
18	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.03303792
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.01162578
20	GATA1_22025678_ChIP-Seq_K562_Human	10.1550132
21	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.93787839
22	ELK1_19687146_ChIP-ChIP_HELA_Human	1.84191802
23	MYC_18940864_ChIP-ChIP_HL60_Human	1.80582201
24	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.76569369
25	EZH2_22144423_ChIP-Seq_EOC_Human	1.76315143
26	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.64514283
27	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.60131701
28	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.57445630
29	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.49981573
30	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.49270219
31	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.47969372
32	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.45288027
33	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.42658604
34	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.41140257
35	VDR_22108803_ChIP-Seq_LS180_Human	1.40649822
36	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.38977732
37	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.36319651
38	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.31280347
39	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.30274992
40	ZNF263_19887448_ChIP-Seq_K562_Human	1.30206630
41	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.26237398
42	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.26015266
43	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.25942372
44	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.25324125
45	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.25198505
46	FOXP3_21729870_ChIP-Seq_TREG_Human	1.25005970
47	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.24449988
48	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.22621272
49	GABP_19822575_ChIP-Seq_HepG2_Human	1.20951199
50	SMAD1_18555785_ChIP-Seq_MESCs_Mouse	1.20834204
51	EWS_26573619_Chip-Seq_HEK293_Human	1.19717240
52	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.17865634
53	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.17315044
54	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.13312506
55	TTF2_22483619_ChIP-Seq_HELA_Human	1.12625491
56	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.12462895
57	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.09665047
58	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.07843294
59	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.07242520
60	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	1.06087631
61	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.05865503
62	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.05078846
63	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.03526726
64	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.02558550
65	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.02006092
66	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.01688326
67	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.00190557
68	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.99742169
69	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.98990583
70	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.98284905
71	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.97245713
72	TAF15_26573619_Chip-Seq_HEK293_Human	0.96648978
73	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.96311197
74	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.95799915
75	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.95395291
76	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.94455756
77	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.94169238
78	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.93887856
79	FUS_26573619_Chip-Seq_HEK293_Human	0.90301538
80	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.88448864
81	XRN2_22483619_ChIP-Seq_HELA_Human	0.88072681
82	SPI1_20517297_ChIP-Seq_HL60_Human	0.86335554
83	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.85778492
84	E2F7_22180533_ChIP-Seq_HELA_Human	0.84704219
85	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.84478269
86	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.83836339
87	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.83622800
88	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.83463301
89	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.83070398
90	NANOG_18358816_ChIP-ChIP_MESCs_Mouse	0.82716399
91	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.82369729
92	POU5F1_18347094_ChIP-ChIP_MESCs_Mouse	0.81933422
93	NCOR_22424771_ChIP-Seq_293T_Human	0.80547978
94	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.79910512
95	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.77894376
96	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.77862608
97	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.76209861
98	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.75593598
99	IRF1_19129219_ChIP-ChIP_H3396_Human	0.75396277
100	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.74942033

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002102_abnormal_ear_morphology	4.48386129
2	MP0001348_abnormal_lacrimal_gland	4.08050282
3	MP0005645_abnormal_hypothalamus_physiol	3.49696144
4	MP0003283_abnormal_digestive_organ	3.35917017
5	MP0003136_yellow_coat_color	3.11418439
6	MP0003693_abnormal_embryo_hatching	2.83680489
7	MP0006276_abnormal_autonomic_nervous	2.72894288
8	MP0002138_abnormal_hepatobiliary_system	2.57675445
9	MP0010386_abnormal_urinary_bladder	2.57060410
10	MP0003878_abnormal_ear_physiology	2.25048262
11	MP0005377_hearing/vestibular/ear_phenot	2.25048262
12	MP0001873_stomach_inflammation	2.23281610
13	MP0000372_irregular_coat_pigmentation	2.21789746
14	MP0001984_abnormal_olfaction	2.06630037
15	MP0003646_muscle_fatigue	2.05062777
16	MP0003763_abnormal_thymus_physiology	2.04413551
17	MP0003122_maternal_imprinting	2.03545314
18	MP0002234_abnormal_pharynx_morphology	2.01631388
19	MP0004147_increased_porphyrin_level	2.00575836
20	MP0002332_abnormal_exercise_endurance	1.99459702
21	MP0004742_abnormal_vestibular_system	1.99263673
22	MP0008872_abnormal_physiological_respon	1.86082596
23	MP0004510_myositis	1.86043743
24	MP0004133_heterotaxia	1.82279278
25	MP0002735_abnormal_chemical_nociception	1.74232348
26	MP0010368_abnormal_lymphatic_system	1.73235786
27	MP0001545_abnormal_hematopoietic_system	1.69415982
28	MP0005397_hematopoietic_system_phenotyp	1.69415982
29	MP0003121_genomic_imprinting	1.68930014
30	MP0005167_abnormal_blood-brain_barrier	1.50015448
31	MP0010094_abnormal_chromosome_stability	1.49255226
32	MP0004957_abnormal_blastocyst_morpholog	1.45146887
33	MP0004145_abnormal_muscle_electrophysio	1.45020633
34	MP0009333_abnormal_splenocyte_physiolog	1.43934662
35	MP0008058_abnormal_DNA_repair	1.43215653
36	MP0003567_abnormal_fetal_cardiomyocyte	1.40802524
37	MP0006138_congestive_heart_failure	1.38193759
38	MP0009745_abnormal_behavioral_response	1.36421140
39	MP0003045_fibrosis	1.35907578
40	MP0000538_abnormal_urinary_bladder	1.35577666
41	MP0004808_abnormal_hematopoietic_stem	1.35467916
42	MP0001501_abnormal_sleep_pattern	1.34484821
43	MP0004858_abnormal_nervous_system	1.29095215
44	MP0008775_abnormal_heart_ventricle	1.27503125
45	MP0001485_abnormal_pinna_reflex	1.20552463
46	MP0001905_abnormal_dopamine_level	1.20360772
47	MP0001529_abnormal_vocalization	1.19663198
48	MP0001293_anophthalmia	1.14858787
49	MP0006082_CNS_inflammation	1.14809801
50	MP0001502_abnormal_circadian_rhythm	1.14262690
51	MP0002733_abnormal_thermal_nociception	1.13013407
52	MP0000631_abnormal_neuroendocrine_gland	1.11564053
53	MP0002736_abnormal_nociception_after	1.08079390
54	MP0003111_abnormal_nucleus_morphology	1.06128262
55	MP0003786_premature_aging	1.04705717
56	MP0003959_abnormal_lean_body	1.00577381
57	MP0000613_abnormal_salivary_gland	1.00287763
58	MP0004142_abnormal_muscle_tone	0.95118647
59	MP0005253_abnormal_eye_physiology	0.95098424
60	MP0001968_abnormal_touch/_nociception	0.94464107
61	MP0009765_abnormal_xenobiotic_induced	0.92654810
62	MP0005319_abnormal_enzyme/_coenzyme	0.87088060
63	MP0006035_abnormal_mitochondrial_morpho	0.85809933
64	MP0000749_muscle_degeneration	0.85046755
65	MP0003943_abnormal_hepatobiliary_system	0.82833766
66	MP0003866_abnormal_defecation	0.82573054
67	MP0003077_abnormal_cell_cycle	0.81583233
68	MP0001919_abnormal_reproductive_system	0.81049107
69	MP0001544_abnormal_cardiovascular_syste	0.80082109
70	MP0005385_cardiovascular_system_phenoty	0.80082109
71	MP0008932_abnormal_embryonic_tissue	0.79978391
72	MP0002938_white_spotting	0.78991138
73	MP0001486_abnormal_startle_reflex	0.77901072
74	MP0005389_reproductive_system_phenotype	0.75611763
75	MP0000604_amyloidosis	0.74771095
76	MP0003119_abnormal_digestive_system	0.71447408
77	MP0002557_abnormal_social/conspecific_i	0.69918641
78	MP0003137_abnormal_impulse_conducting	0.69391557
79	MP0003635_abnormal_synaptic_transmissio	0.68511032
80	MP0002909_abnormal_adrenal_gland	0.67367964
81	MP0001764_abnormal_homeostasis	0.67178186
82	MP0006072_abnormal_retinal_apoptosis	0.66159388
83	MP0005387_immune_system_phenotype	0.64041302
84	MP0001790_abnormal_immune_system	0.64041302
85	MP0001970_abnormal_pain_threshold	0.62968113
86	MP0005551_abnormal_eye_electrophysiolog	0.62918590
87	MP0002064_seizures	0.62612416
88	MP0003938_abnormal_ear_development	0.61972302
89	MP0000026_abnormal_inner_ear	0.61682565
90	MP0002572_abnormal_emotion/affect_behav	0.60703127
91	MP0004381_abnormal_hair_follicle	0.60571004
92	MP0000465_gastrointestinal_hemorrhage	0.60306575
93	MP0009697_abnormal_copulation	0.60205238
94	MP0005195_abnormal_posterior_eye	0.58925652
95	MP0002210_abnormal_sex_determination	0.57825019
96	MP0005671_abnormal_response_to	0.57617150
97	MP0006292_abnormal_olfactory_placode	0.53684195
98	MP0005367_renal/urinary_system_phenotyp	0.53232017
99	MP0000516_abnormal_urinary_system	0.53232017
100	MP0002184_abnormal_innervation	0.53008286

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Generalized aminoaciduria (HP:0002909)	6.31867294
2	Chronic diarrhea (HP:0002028)	5.24936528
3	Proximal tubulopathy (HP:0000114)	4.37350141
4	Pendular nystagmus (HP:0012043)	4.29520189
5	True hermaphroditism (HP:0010459)	3.97905888
6	Severe visual impairment (HP:0001141)	3.77338941
7	Pancreatic cysts (HP:0001737)	3.70691004
8	Pancreatic fibrosis (HP:0100732)	3.39289712
9	Abolished electroretinogram (ERG) (HP:0000550)	3.38549139
10	Degeneration of anterior horn cells (HP:0002398)	3.30566859
11	Abnormality of the anterior horn cell (HP:0006802)	3.30566859
12	Abnormal number of incisors (HP:0011064)	3.23665828
13	Congenital stationary night blindness (HP:0007642)	3.21822577
14	Aplastic anemia (HP:0001915)	3.13796403
15	Bilateral microphthalmos (HP:0007633)	3.06118108
16	Megalencephaly (HP:0001355)	2.99566958
17	Oral leukoplakia (HP:0002745)	2.98673387
18	Oligodactyly (hands) (HP:0001180)	2.92453147
19	Hyperglycinuria (HP:0003108)	2.77157482
20	Inflammation of the large intestine (HP:0002037)	2.74012024
21	Severe combined immunodeficiency (HP:0004430)	2.71074572
22	Hypoplastic pelvis (HP:0008839)	2.69821170
23	Sclerocornea (HP:0000647)	2.66192000
24	Abnormality of the labia minora (HP:0012880)	2.63409741
25	Abnormality of placental membranes (HP:0011409)	2.61617511
26	Amniotic constriction ring (HP:0009775)	2.61617511
27	Abnormal number of erythroid precursors (HP:0012131)	2.54504645
28	Gastrointestinal inflammation (HP:0004386)	2.54454307
29	Thyroiditis (HP:0100646)	2.52829098
30	Neonatal respiratory distress (HP:0002643)	2.52672998
31	Abnormality of B cell number (HP:0010975)	2.52392864
32	Agnosia (HP:0010524)	2.47962948
33	Preaxial hand polydactyly (HP:0001177)	2.39698370
34	Cystic liver disease (HP:0006706)	2.39414450
35	Patent foramen ovale (HP:0001655)	2.35774699
36	Glycosuria (HP:0003076)	2.34854527
37	Abnormality of urine glucose concentration (HP:0011016)	2.34854527
38	Cystic hygroma (HP:0000476)	2.29919971
39	Attenuation of retinal blood vessels (HP:0007843)	2.29834599
40	Central scotoma (HP:0000603)	2.27754128
41	Concave nail (HP:0001598)	2.20308984
42	Oligodactyly (HP:0012165)	2.18532158
43	Combined immunodeficiency (HP:0005387)	2.18063868
44	Postaxial foot polydactyly (HP:0001830)	2.15119575
45	Abnormality of serum amino acid levels (HP:0003112)	2.14775472
46	Popliteal pterygium (HP:0009756)	2.11777834
47	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.09620861
48	Hypoplasia of the fovea (HP:0007750)	2.09620861
49	Abnormality of homocysteine metabolism (HP:0010919)	2.08817189
50	Homocystinuria (HP:0002156)	2.08817189
51	Myokymia (HP:0002411)	2.07891024
52	Upper limb muscle weakness (HP:0003484)	2.07690210
53	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.06826774
54	Abnormality of the incisor (HP:0000676)	2.06200175
55	Parakeratosis (HP:0001036)	2.05049605
56	Decreased central vision (HP:0007663)	2.01701460
57	Respiratory difficulties (HP:0002880)	2.00080626
58	Anophthalmia (HP:0000528)	1.98743177
59	Bile duct proliferation (HP:0001408)	1.98651622
60	Abnormal biliary tract physiology (HP:0012439)	1.98651622
61	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.98134921
62	Abnormality of methionine metabolism (HP:0010901)	1.97683179
63	Rib fusion (HP:0000902)	1.96505134
64	Increased corneal curvature (HP:0100692)	1.95409776
65	Keratoconus (HP:0000563)	1.95409776
66	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.94901872
67	Nausea (HP:0002018)	1.94748779
68	CNS hypomyelination (HP:0003429)	1.93641933
69	Abnormality of glycine metabolism (HP:0010895)	1.93409718
70	Abnormality of serine family amino acid metabolism (HP:0010894)	1.93409718
71	Mutism (HP:0002300)	1.90230329
72	Small hand (HP:0200055)	1.88957605
73	Neoplasm of the peripheral nervous system (HP:0100007)	1.88659850
74	Cerebral hypomyelination (HP:0006808)	1.88188573
75	Dyschromatopsia (HP:0007641)	1.87665696
76	B lymphocytopenia (HP:0010976)	1.84991664
77	High anterior hairline (HP:0009890)	1.84446705
78	Scotoma (HP:0000575)	1.83667464
79	Acute necrotizing encephalopathy (HP:0006965)	1.82238302
80	Abnormality of proline metabolism (HP:0010907)	1.79755009
81	Hydroxyprolinuria (HP:0003080)	1.79755009
82	Mesangial abnormality (HP:0001966)	1.79429292
83	Abnormality of abdominal situs (HP:0011620)	1.79143147
84	Abdominal situs inversus (HP:0003363)	1.79143147
85	Abnormality of cells of the erythroid lineage (HP:0012130)	1.78032348
86	Fused cervical vertebrae (HP:0002949)	1.76367158
87	Hyperphosphaturia (HP:0003109)	1.76279995
88	Freckling (HP:0001480)	1.75487169
89	Ependymoma (HP:0002888)	1.73744688
90	Hyperglycinemia (HP:0002154)	1.72186018
91	Optic nerve hypoplasia (HP:0000609)	1.71912737
92	Cerebral palsy (HP:0100021)	1.69719872
93	Aplasia/Hypoplasia of the macula (HP:0008059)	1.69427597
94	Hypoglycemic coma (HP:0001325)	1.69305168
95	Abnormality of T cell number (HP:0011839)	1.68291491
96	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.67567465
97	Delayed gross motor development (HP:0002194)	1.65639182
98	Growth hormone deficiency (HP:0000824)	1.64656403
99	Aplasia of the musculature (HP:0100854)	1.63826100
100	Secondary amenorrhea (HP:0000869)	1.62023727

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TIE1	5.87767197
2	BCKDK	3.65289659
3	ZAK	3.59288218
4	BMPR1B	3.08322065
5	BUB1	2.93176057
6	ACVR1B	2.49123841
7	PAK6	2.43116819
8	CDC7	1.89468480
9	ADRBK2	1.84285272
10	FES	1.77567479
11	VRK1	1.62242765
12	GRK1	1.61314201
13	WNK3	1.59375775
14	AURKA	1.59203092
15	DYRK2	1.57550209
16	PIM2	1.54271929
17	PBK	1.52760043
18	TLK1	1.52745879
19	CSNK1G1	1.49924247
20	TXK	1.47132922
21	NEK1	1.41877286
22	SRPK1	1.37747350
23	RAF1	1.33599734
24	FRK	1.31777327
25	PAK3	1.31504530
26	EIF2AK3	1.30280655
27	TRIM28	1.29833295
28	ALK	1.25171300
29	PHKG2	1.21486695
30	PHKG1	1.21486695
31	CSNK1G3	1.21474647
32	RPS6KA5	1.14823173
33	TESK1	1.12992235
34	JAK3	1.09630276
35	NEK9	1.07836677
36	CSNK1G2	1.05024054
37	VRK2	1.04942917
38	MKNK1	1.04175530
39	CDK19	1.01094298
40	PLK1	1.00742227
41	TEC	1.00243142
42	NUAK1	1.00173982
43	LMTK2	0.97353662
44	KDR	0.97003185
45	PIK3CA	0.96734507
46	TGFBR1	0.96327558
47	CSNK1A1L	0.92430886
48	TYRO3	0.89556035
49	BCR	0.87615949
50	KSR2	0.86555475
51	KSR1	0.84066311
52	CDK8	0.83181324
53	MARK1	0.80770275
54	EIF2AK1	0.77927347
55	MAP2K7	0.77365602
56	MKNK2	0.75709673
57	CHEK2	0.75013350
58	AKT2	0.74431067
59	TSSK6	0.73707398
60	PLK3	0.71220863
61	FER	0.70625255
62	TESK2	0.68135000
63	CSNK1A1	0.64660010
64	BRD4	0.63647103
65	PRKAA2	0.62398190
66	TTK	0.61568258
67	CHEK1	0.60877196
68	MAP3K4	0.58935312
69	GRK7	0.55008859
70	STK16	0.54955563
71	AURKB	0.54743856
72	PAK1	0.53455488
73	INSRR	0.52815759
74	ITK	0.50690416
75	JAK2	0.50462092
76	OBSCN	0.47580563
77	PRKCG	0.47115958
78	STK39	0.45919756
79	GRK5	0.45542062
80	NLK	0.44752326
81	PRKACB	0.44465082
82	DAPK3	0.44010420
83	CSNK2A1	0.43740325
84	MAP2K6	0.41649167
85	EGFR	0.40299799
86	EIF2AK2	0.39572261
87	MATK	0.39087095
88	MAP2K1	0.38688523
89	LYN	0.36499605
90	BRAF	0.35978443
91	UHMK1	0.35182636
92	KIT	0.34864419
93	MST4	0.34279186
94	MAP4K2	0.31067664
95	PRKCB	0.30639056
96	PLK4	0.30140946
97	CDK11A	0.29942971
98	ATR	0.29875818
99	PRKACA	0.29465384
100	PRKCQ	0.28596974

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.37571295
2	Renin-angiotensin system_Homo sapiens_hsa04614	2.67681034
3	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.65412011
4	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.38972786
5	Phototransduction_Homo sapiens_hsa04744	2.38486590
6	Homologous recombination_Homo sapiens_hsa03440	2.32169634
7	Alcoholism_Homo sapiens_hsa05034	2.21172788
8	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.20748582
9	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.19542756
10	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.09887124
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.06855131
12	One carbon pool by folate_Homo sapiens_hsa00670	2.06389680
13	Nitrogen metabolism_Homo sapiens_hsa00910	1.95773554
14	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.94588562
15	Selenocompound metabolism_Homo sapiens_hsa00450	1.84235760
16	Mismatch repair_Homo sapiens_hsa03430	1.84098654
17	Sulfur relay system_Homo sapiens_hsa04122	1.79756481
18	DNA replication_Homo sapiens_hsa03030	1.77736695
19	Parkinsons disease_Homo sapiens_hsa05012	1.74474861
20	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.68572551
21	Spliceosome_Homo sapiens_hsa03040	1.65028988
22	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.62964718
23	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.58687977
24	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.56735245
25	Butanoate metabolism_Homo sapiens_hsa00650	1.53145312
26	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.47271566
27	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.42063532
28	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.41338699
29	Arginine biosynthesis_Homo sapiens_hsa00220	1.40018968
30	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.34425625
31	RNA transport_Homo sapiens_hsa03013	1.34001180
32	Oxidative phosphorylation_Homo sapiens_hsa00190	1.33652243
33	RNA polymerase_Homo sapiens_hsa03020	1.28766547
34	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.27179720
35	Arginine and proline metabolism_Homo sapiens_hsa00330	1.26057047
36	p53 signaling pathway_Homo sapiens_hsa04115	1.24569485
37	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.11475814
38	Taste transduction_Homo sapiens_hsa04742	1.11348895
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.11187973
40	Jak-STAT signaling pathway_Homo sapiens_hsa04630	1.10699857
41	Base excision repair_Homo sapiens_hsa03410	1.09435137
42	Primary immunodeficiency_Homo sapiens_hsa05340	1.08433503
43	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.07252796
44	Non-homologous end-joining_Homo sapiens_hsa03450	1.05821063
45	Linoleic acid metabolism_Homo sapiens_hsa00591	1.05129957
46	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.03138224
47	Propanoate metabolism_Homo sapiens_hsa00640	1.02393125
48	Pyrimidine metabolism_Homo sapiens_hsa00240	1.01749448
49	Retinol metabolism_Homo sapiens_hsa00830	1.01632096
50	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.99607089
51	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.97024013
52	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.91964634
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.89794316
54	Fatty acid elongation_Homo sapiens_hsa00062	0.87386157
55	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.87285198
56	Protein export_Homo sapiens_hsa03060	0.85021772
57	Nucleotide excision repair_Homo sapiens_hsa03420	0.84854445
58	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.83057165
59	Chemical carcinogenesis_Homo sapiens_hsa05204	0.82271970
60	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.82129235
61	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.80626549
62	Sulfur metabolism_Homo sapiens_hsa00920	0.80368350
63	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.77980229
64	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.77228562
65	Tryptophan metabolism_Homo sapiens_hsa00380	0.75159281
66	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.74806403
67	Nicotine addiction_Homo sapiens_hsa05033	0.74672894
68	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.74238347
69	Carbon metabolism_Homo sapiens_hsa01200	0.73964609
70	Allograft rejection_Homo sapiens_hsa05330	0.71779018
71	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.70892573
72	Cell cycle_Homo sapiens_hsa04110	0.70824990
73	Alzheimers disease_Homo sapiens_hsa05010	0.68098110
74	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.67227160
75	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.66666047
76	Purine metabolism_Homo sapiens_hsa00230	0.66314227
77	Asthma_Homo sapiens_hsa05310	0.65501637
78	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.64354738
79	Cardiac muscle contraction_Homo sapiens_hsa04260	0.63901518
80	Peroxisome_Homo sapiens_hsa04146	0.63649191
81	Ribosome_Homo sapiens_hsa03010	0.63624952
82	Fatty acid metabolism_Homo sapiens_hsa01212	0.62981632
83	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.60637978
84	Pentose phosphate pathway_Homo sapiens_hsa00030	0.58166883
85	Metabolic pathways_Homo sapiens_hsa01100	0.56274764
86	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.54764652
87	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.54134998
88	Huntingtons disease_Homo sapiens_hsa05016	0.51257156
89	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.47965658
90	RNA degradation_Homo sapiens_hsa03018	0.46766716
91	Galactose metabolism_Homo sapiens_hsa00052	0.45156618
92	mRNA surveillance pathway_Homo sapiens_hsa03015	0.45134994
93	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.44110921
94	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.43752295
95	Hippo signaling pathway_Homo sapiens_hsa04390	0.43544925
96	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.42294759
97	Glutathione metabolism_Homo sapiens_hsa00480	0.40143884
98	Fanconi anemia pathway_Homo sapiens_hsa03460	0.37721418
99	Fatty acid degradation_Homo sapiens_hsa00071	0.36263043
100	Morphine addiction_Homo sapiens_hsa05032	0.36137342

PGAM1P10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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