PGAM1P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine metabolic process (GO:0046087)9.35041702
2cytidine catabolic process (GO:0006216)9.35041702
3cytidine deamination (GO:0009972)9.35041702
4DNA deamination (GO:0045006)8.79765591
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450918.73685630
6pyrimidine ribonucleoside catabolic process (GO:0046133)8.32679480
7Arp2/3 complex-mediated actin nucleation (GO:0034314)4.86556638
8regulation of cellular amino acid metabolic process (GO:0006521)4.82874296
9DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.65249842
10signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.52150412
11signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.52150412
12signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.52150412
13signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.50228959
14intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.50228959
15negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.46312790
16signal transduction involved in DNA integrity checkpoint (GO:0072401)4.36045145
17signal transduction involved in DNA damage checkpoint (GO:0072422)4.36045145
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:4.32890081
19signal transduction involved in cell cycle checkpoint (GO:0072395)4.30143816
20actin nucleation (GO:0045010)4.27535766
21pyrimidine nucleoside catabolic process (GO:0046135)4.18382778
22regulation of chronic inflammatory response (GO:0002676)4.18134181
23positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.07664210
24antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)4.06164657
25positive regulation of defense response to virus by host (GO:0002230)4.01778429
26negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.97624504
27negative regulation of ligase activity (GO:0051352)3.97624504
28sequestering of actin monomers (GO:0042989)3.82258436
29negative regulation by host of viral transcription (GO:0043922)3.77687569
30regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.76903739
31negative regulation of viral genome replication (GO:0045071)3.75160415
32regulation of regulatory T cell differentiation (GO:0045589)3.73632101
33positive regulation of cell cycle arrest (GO:0071158)3.64730515
34protein maturation by protein folding (GO:0022417)3.64603558
35mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.59740855
36positive regulation of lamellipodium assembly (GO:0010592)3.59126493
37positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.55150791
38macrophage chemotaxis (GO:0048246)3.54465848
39L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.48790617
40platelet dense granule organization (GO:0060155)3.43774248
41iron-sulfur cluster assembly (GO:0016226)3.43226754
42metallo-sulfur cluster assembly (GO:0031163)3.43226754
43anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.42126546
44DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.42042225
45positive thymic T cell selection (GO:0045059)3.41438555
46negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.39168914
47regulation of cellular amine metabolic process (GO:0033238)3.39151934
48positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.38795110
49positive T cell selection (GO:0043368)3.36042199
50ATP synthesis coupled proton transport (GO:0015986)3.34544214
51energy coupled proton transport, down electrochemical gradient (GO:0015985)3.34544214
52antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.34481645
53positive regulation of interleukin-8 secretion (GO:2000484)3.30621817
54positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.30479135
55eosinophil chemotaxis (GO:0048245)3.27090581
56positive regulation of ligase activity (GO:0051351)3.25670377
57negative regulation of T cell apoptotic process (GO:0070233)3.25105455
58positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.21060708
59positive regulation of natural killer cell mediated immunity (GO:0002717)3.20024682
60DNA demethylation (GO:0080111)3.19852853
61T cell migration (GO:0072678)3.18770165
62regulation of cell cycle arrest (GO:0071156)3.18709945
63protein neddylation (GO:0045116)3.10527883
64positive regulation of gamma-delta T cell activation (GO:0046645)3.07149031
65lymphocyte chemotaxis (GO:0048247)3.04700581
66regulation of leukocyte mediated cytotoxicity (GO:0001910)3.03729141
67regulation of T cell receptor signaling pathway (GO:0050856)3.00409814
68positive regulation of cell killing (GO:0031343)3.00220298
69protein deneddylation (GO:0000338)2.99535598
70regulation of natural killer cell mediated immunity (GO:0002715)2.98911632
71regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.98911632
72proteasome assembly (GO:0043248)2.97946398
73purine deoxyribonucleotide catabolic process (GO:0009155)2.96055279
74negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.95786711
75cullin deneddylation (GO:0010388)2.94813375
76eosinophil migration (GO:0072677)2.94572710
77regulation of B cell receptor signaling pathway (GO:0050855)2.93777564
78regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.93224451
79pyrimidine-containing compound catabolic process (GO:0072529)2.90291145
80response to interferon-beta (GO:0035456)2.89591822
81post-embryonic morphogenesis (GO:0009886)2.88482714
82negative regulation of cell cycle G1/S phase transition (GO:1902807)2.87443745
83negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.87443745
84L-methionine biosynthetic process (GO:0071265)2.86888201
85amino acid salvage (GO:0043102)2.86888201
86L-methionine salvage (GO:0071267)2.86888201
87signal transduction in response to DNA damage (GO:0042770)2.84166111
88positive regulation of tolerance induction (GO:0002645)2.83844474
89positive regulation of T cell mediated cytotoxicity (GO:0001916)2.82498118
90respiratory electron transport chain (GO:0022904)2.82342044
91regulation of cell killing (GO:0031341)2.82325301
92detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.81122027
93natural killer cell activation (GO:0030101)2.79076304
94regulation of isotype switching to IgG isotypes (GO:0048302)2.78318536
95regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.78186239
96establishment of protein localization to mitochondrial membrane (GO:0090151)2.77715712
97regulation of viral genome replication (GO:0045069)2.77712252
98DNA dealkylation (GO:0035510)2.77375474
99positive regulation of calcium-mediated signaling (GO:0050850)2.76666806
100transcription elongation from RNA polymerase III promoter (GO:0006385)2.76348422

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.27799539
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.99202396
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.75921733
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.73367933
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.61499935
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.59247126
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.30153708
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.18262816
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.94727871
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.91662628
11VDR_23849224_ChIP-Seq_CD4+_Human2.55990837
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.53369913
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.45779429
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.40403059
15MYB_26560356_Chip-Seq_TH2_Human2.35726455
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.28849382
17IRF8_21731497_ChIP-ChIP_J774_Mouse2.26450035
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.21276306
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.19677707
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.18822783
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.99978913
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.98006871
23STAT4_19710469_ChIP-ChIP_TH1__Mouse1.97156940
24YY1_21170310_ChIP-Seq_MESCs_Mouse1.93212985
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.91114557
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.83521490
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.81979985
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.79723208
29CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.78653547
30FOXP3_21729870_ChIP-Seq_TREG_Human1.77066724
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.71532872
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64766847
33PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.62765869
34VDR_22108803_ChIP-Seq_LS180_Human1.59790490
35CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.59463896
36LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.58062430
37GATA3_26560356_Chip-Seq_TH2_Human1.57876025
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.56659525
39BCL6_27268052_Chip-Seq_Bcells_Human1.52196762
40SRY_22984422_ChIP-ChIP_TESTIS_Rat1.50969841
41EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.49378124
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46697653
43RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.45375818
44CIITA_25753668_ChIP-Seq_RAJI_Human1.42516544
45GATA3_27048872_Chip-Seq_THYMUS_Human1.41847245
46ZNF274_21170338_ChIP-Seq_K562_Hela1.39186370
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38271971
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.37707030
49CTCF_20526341_ChIP-Seq_ESCs_Human1.36891246
50CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.33935502
51MYC_18940864_ChIP-ChIP_HL60_Human1.33478227
52CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31623325
53ELK1_19687146_ChIP-ChIP_HELA_Human1.30698021
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29753044
55GABP_19822575_ChIP-Seq_HepG2_Human1.29509069
56PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.27636416
57TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.25027457
58TP53_22573176_ChIP-Seq_HFKS_Human1.24767677
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.24333590
60DCP1A_22483619_ChIP-Seq_HELA_Human1.22663704
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22649168
62MYB_26560356_Chip-Seq_TH1_Human1.21481293
63HTT_18923047_ChIP-ChIP_STHdh_Human1.21400289
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20627878
65MAF_26560356_Chip-Seq_TH1_Human1.20333704
66UTX_26944678_Chip-Seq_JUKART_Human1.20186475
67BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17284553
68RUNX_20019798_ChIP-Seq_JUKART_Human1.16793695
69MAF_26560356_Chip-Seq_TH2_Human1.14451590
70P300_27268052_Chip-Seq_Bcells_Human1.14060041
71BCOR_27268052_Chip-Seq_Bcells_Human1.13537816
72RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10182463
73TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09832515
74MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.07052199
75FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.06310032
76FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05587779
77KDM5A_27292631_Chip-Seq_BREAST_Human1.04362657
78HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03822613
79E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.02129219
80ELK1_22589737_ChIP-Seq_MCF10A_Human1.01687070
81ERA_21632823_ChIP-Seq_H3396_Human1.01540813
82E2F1_20622854_ChIP-Seq_HELA_Human0.99542560
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99280639
84TAF2_19829295_ChIP-Seq_ESCs_Human0.97407997
85SPI1_23547873_ChIP-Seq_NB4_Human0.97330410
86ELF1_20517297_ChIP-Seq_JURKAT_Human0.94341581
87MYC_19030024_ChIP-ChIP_MESCs_Mouse0.94287435
88NELFA_20434984_ChIP-Seq_ESCs_Mouse0.94024861
89AR_20517297_ChIP-Seq_VCAP_Human0.93952824
90RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92389255
91SA1_27219007_Chip-Seq_Bcells_Human0.92370094
92NANOG_20526341_ChIP-Seq_ESCs_Human0.91269232
93GATA3_26560356_Chip-Seq_TH1_Human0.89740560
94MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.89207858
95FOXA1_27270436_Chip-Seq_PROSTATE_Human0.88956171
96FOXA1_25329375_ChIP-Seq_VCAP_Human0.88956171
97CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88191542
98HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87567773
99LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.87159315
100GATA3_21878914_ChIP-Seq_MCF-7_Human0.84278594

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.69262212
2MP0009785_altered_susceptibility_to3.13911813
3MP0006072_abnormal_retinal_apoptosis2.97509010
4MP0001835_abnormal_antigen_presentation2.89507590
5MP0009333_abnormal_splenocyte_physiolog2.78454760
6MP0000685_abnormal_immune_system2.56245160
7MP0003011_delayed_dark_adaptation2.54874511
8MP0003763_abnormal_thymus_physiology2.47894038
9MP0000372_irregular_coat_pigmentation2.44670070
10MP0002166_altered_tumor_susceptibility2.43178905
11MP0002102_abnormal_ear_morphology2.42770144
12MP0001873_stomach_inflammation2.35631255
13MP0002148_abnormal_hypersensitivity_rea2.20860157
14MP0005025_abnormal_response_to2.07275005
15MP0002006_tumorigenesis2.03002885
16MP0001800_abnormal_humoral_immune1.96281158
17MP0006082_CNS_inflammation1.95989566
18MP0001986_abnormal_taste_sensitivity1.94547356
19MP0005000_abnormal_immune_tolerance1.94278911
20MP0002277_abnormal_respiratory_mucosa1.89869397
21MP0002723_abnormal_immune_serum1.76464890
22MP0002420_abnormal_adaptive_immunity1.76101383
23MP0003866_abnormal_defecation1.73278674
24MP0001905_abnormal_dopamine_level1.71297821
25MP0001819_abnormal_immune_cell1.67876212
26MP0005387_immune_system_phenotype1.67115377
27MP0001790_abnormal_immune_system1.67115377
28MP0003806_abnormal_nucleotide_metabolis1.54588440
29MP0001501_abnormal_sleep_pattern1.51563514
30MP0004145_abnormal_muscle_electrophysio1.50991511
31MP0006276_abnormal_autonomic_nervous1.48024393
32MP0002822_catalepsy1.45992443
33MP0008058_abnormal_DNA_repair1.45083839
34MP0004147_increased_porphyrin_level1.45072868
35MP0003786_premature_aging1.44775540
36MP0005253_abnormal_eye_physiology1.43751920
37MP0000716_abnormal_immune_system1.41056459
38MP0009764_decreased_sensitivity_to1.37525192
39MP0002452_abnormal_antigen_presenting1.36760813
40MP0001919_abnormal_reproductive_system1.35315975
41MP0002398_abnormal_bone_marrow1.33876562
42MP0002405_respiratory_system_inflammati1.30505122
43MP0006036_abnormal_mitochondrial_physio1.26859611
44MP0008872_abnormal_physiological_respon1.26166749
45MP0008875_abnormal_xenobiotic_pharmacok1.25617064
46MP0002736_abnormal_nociception_after1.25372391
47MP0010155_abnormal_intestine_physiology1.23702416
48MP0003195_calcinosis1.22573860
49MP0000703_abnormal_thymus_morphology1.21500809
50MP0009745_abnormal_behavioral_response1.21091594
51MP0003646_muscle_fatigue1.21091198
52MP0004510_myositis1.20079524
53MP0002876_abnormal_thyroid_physiology1.19262285
54MP0002095_abnormal_skin_pigmentation1.17323661
55MP0005423_abnormal_somatic_nervous1.17290599
56MP0001984_abnormal_olfaction1.15895194
57MP0000689_abnormal_spleen_morphology1.11655301
58MP0001845_abnormal_inflammatory_respons1.10439255
59MP0008469_abnormal_protein_level1.10206913
60MP0002722_abnormal_immune_system1.08326313
61MP0002429_abnormal_blood_cell1.07806156
62MP0001968_abnormal_touch/_nociception1.07690982
63MP0001529_abnormal_vocalization1.05631114
64MP0001542_abnormal_bone_strength1.04120214
65MP0008789_abnormal_olfactory_epithelium1.03426435
66MP0002254_reproductive_system_inflammat1.02987816
67MP0003448_altered_tumor_morphology1.02550504
68MP0008995_early_reproductive_senescence1.00726103
69MP0001853_heart_inflammation0.98677422
70MP0002933_joint_inflammation0.96640965
71MP0009697_abnormal_copulation0.96294769
72MP0002019_abnormal_tumor_incidence0.96254782
73MP0001119_abnormal_female_reproductive0.95180567
74MP0000490_abnormal_crypts_of0.93775370
75MP0006035_abnormal_mitochondrial_morpho0.91454168
76MP0003137_abnormal_impulse_conducting0.89588304
77MP0001188_hyperpigmentation0.89338162
78MP0005636_abnormal_mineral_homeostasis0.89140429
79MP0004947_skin_inflammation0.88301606
80MP0009763_increased_sensitivity_to0.87450230
81MP0005551_abnormal_eye_electrophysiolog0.85333405
82MP0005166_decreased_susceptibility_to0.84445300
83MP0003878_abnormal_ear_physiology0.83728481
84MP0005377_hearing/vestibular/ear_phenot0.83728481
85MP0005257_abnormal_intraocular_pressure0.83230185
86MP0002733_abnormal_thermal_nociception0.81821408
87MP0002419_abnormal_innate_immunity0.79089817
88MP0004270_analgesia0.78762673
89MP0003638_abnormal_response/metabolism_0.74413846
90MP0003724_increased_susceptibility_to0.73431208
91MP0005645_abnormal_hypothalamus_physiol0.72781792
92MP0002751_abnormal_autonomic_nervous0.72131469
93MP0005389_reproductive_system_phenotype0.71889447
94MP0005085_abnormal_gallbladder_physiolo0.71886257
95MP0002210_abnormal_sex_determination0.70654731
96MP0005408_hypopigmentation0.68709700
97MP0000858_altered_metastatic_potential0.64382198
98MP0000639_abnormal_adrenal_gland0.64271278
99MP0003436_decreased_susceptibility_to0.62543697
100MP0005584_abnormal_enzyme/coenzyme_acti0.61503282

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)5.97252671
2T lymphocytopenia (HP:0005403)4.50968821
3IgG deficiency (HP:0004315)4.27836402
4Abnormality of T cell number (HP:0011839)4.04171542
5Congenital stationary night blindness (HP:0007642)3.97550470
6Hepatocellular necrosis (HP:0001404)3.94769271
7Elevated erythrocyte sedimentation rate (HP:0003565)3.94133760
8Increased intramyocellular lipid droplets (HP:0012240)3.76842960
9Mitochondrial inheritance (HP:0001427)3.74899226
10Abnormal mitochondria in muscle tissue (HP:0008316)3.65533739
11Acute necrotizing encephalopathy (HP:0006965)3.63008605
12Hepatic necrosis (HP:0002605)3.45953375
13Decreased activity of mitochondrial respiratory chain (HP:0008972)3.43974862
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.43974862
15Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.36148707
163-Methylglutaconic aciduria (HP:0003535)3.29832216
17Increased CSF lactate (HP:0002490)3.19756106
18Aplasia/hypoplasia of the uterus (HP:0008684)3.11465078
19Increased muscle lipid content (HP:0009058)3.05585296
20Severe combined immunodeficiency (HP:0004430)3.04328375
21Abnormality of T cells (HP:0002843)2.96978503
22Hypoproteinemia (HP:0003075)2.93481809
23Progressive macrocephaly (HP:0004481)2.86913160
24Increased IgM level (HP:0003496)2.85778304
25Increased hepatocellular lipid droplets (HP:0006565)2.81331697
26Acute encephalopathy (HP:0006846)2.80459971
27Recurrent bronchitis (HP:0002837)2.73539555
28Autoimmune hemolytic anemia (HP:0001890)2.68534678
29Renal Fanconi syndrome (HP:0001994)2.64463715
30Agammaglobulinemia (HP:0004432)2.63048634
31Pancreatic cysts (HP:0001737)2.56212683
32Abnormality of eosinophils (HP:0001879)2.55425768
33Stomatitis (HP:0010280)2.49690663
34Chronic diarrhea (HP:0002028)2.47788698
35Increased serum lactate (HP:0002151)2.45940815
36Microretrognathia (HP:0000308)2.45742560
37Delayed CNS myelination (HP:0002188)2.45375787
38Palpebral edema (HP:0100540)2.44887174
39Anhidrosis (HP:0000970)2.44738651
40Hypoplasia of the uterus (HP:0000013)2.44053431
41Lipid accumulation in hepatocytes (HP:0006561)2.42941064
42Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.41809715
43Reduced subcutaneous adipose tissue (HP:0003758)2.37536620
44Optic disc pallor (HP:0000543)2.32826292
45Thyroiditis (HP:0100646)2.32799920
46Decreased electroretinogram (ERG) amplitude (HP:0000654)2.32072197
47Exercise intolerance (HP:0003546)2.29487377
48Emotional lability (HP:0000712)2.25981202
49Cerebral edema (HP:0002181)2.22935497
50Type I transferrin isoform profile (HP:0003642)2.20817437
51Combined immunodeficiency (HP:0005387)2.20493590
52Eosinophilia (HP:0001880)2.19518656
53Orthostatic hypotension (HP:0001278)2.17226728
54Arthropathy (HP:0003040)2.16491300
55Abnormality of the prostate (HP:0008775)2.16008271
56Dysautonomia (HP:0002459)2.14528620
57Fibular aplasia (HP:0002990)2.11439592
58Lactic acidosis (HP:0003128)2.11052950
59Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.10101203
60Abnormal protein N-linked glycosylation (HP:0012347)2.10101203
61Abnormal protein glycosylation (HP:0012346)2.10101203
62Abnormal glycosylation (HP:0012345)2.10101203
63Respiratory failure (HP:0002878)2.09313752
64Posterior subcapsular cataract (HP:0007787)2.03184919
65Oral leukoplakia (HP:0002745)2.02693646
66Exertional dyspnea (HP:0002875)2.01806073
67Chronic mucocutaneous candidiasis (HP:0002728)1.98013356
68Recurrent cutaneous fungal infections (HP:0011370)1.98013356
69Encephalitis (HP:0002383)1.97756457
70Recurrent corneal erosions (HP:0000495)1.94795989
71Severe visual impairment (HP:0001141)1.94582474
72Adactyly (HP:0009776)1.91431409
73Radial bowing (HP:0002986)1.87807107
74Hydroureter (HP:0000072)1.86835383
75Tongue fasciculations (HP:0001308)1.84892931
76Lymphopenia (HP:0001888)1.84020559
77Bronchitis (HP:0012387)1.83491357
78Cerebral palsy (HP:0100021)1.83103387
79Reduced antithrombin III activity (HP:0001976)1.82809021
80Abnormal albumin level (HP:0012116)1.82354780
81Hypoalbuminemia (HP:0003073)1.82354780
82Glucose intolerance (HP:0000833)1.82106621
83X-linked dominant inheritance (HP:0001423)1.81208103
84IgM deficiency (HP:0002850)1.80848456
85Gastrointestinal infarctions (HP:0005244)1.78813533
86Pancytopenia (HP:0001876)1.78376055
87Sensorimotor neuropathy (HP:0007141)1.76792552
88Progressive inability to walk (HP:0002505)1.76610490
89Amyotrophic lateral sclerosis (HP:0007354)1.76234740
90Conical tooth (HP:0000698)1.75572465
91Recurrent otitis media (HP:0000403)1.75320161
92Cerebral hypomyelination (HP:0006808)1.75260087
93B lymphocytopenia (HP:0010976)1.75042842
94Leukocytosis (HP:0001974)1.73925967
95Oligomenorrhea (HP:0000876)1.73616902
96Limb dystonia (HP:0002451)1.71624543
97Atrophy/Degeneration involving motor neurons (HP:0007373)1.70884826
98Abnormality of cells of the lymphoid lineage (HP:0012140)1.69886995
99Hypoplastic pelvis (HP:0008839)1.68984181
100Abnormality of macrophages (HP:0004311)1.68389322

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK29.86683752
2TXK4.32571112
3KDR4.09768888
4ZAK3.70584488
5TESK13.18455054
6TLK13.06250684
7MAP4K22.64355529
8LIMK12.29194474
9GRK12.26769831
10VRK22.14245269
11DAPK11.91258304
12MST41.86685065
13VRK11.85987082
14MAPKAPK31.85240769
15MAP3K121.81682072
16TRIM281.52434545
17SRPK11.52274233
18BCKDK1.48347164
19MATK1.24872653
20LMTK21.23805116
21NTRK11.19477587
22CSNK1G31.18949301
23CSNK1A1L1.09870245
24NUAK11.09165564
25RPS6KA40.99165314
26SIK30.97738971
27CSNK1G10.97363081
28TNK20.95873846
29MAP4K10.95338074
30NME10.92259821
31CSNK1G20.88638831
32MYLK0.86872955
33AURKA0.84550999
34FES0.83212420
35ITK0.81306536
36SYK0.74499524
37PHKG20.72039418
38PHKG10.72039418
39GRK70.69028394
40BUB10.68798749
41CSK0.67882882
42MAP2K70.65872891
43NME20.64102470
44CAMKK20.64096623
45LCK0.60373253
46ADRBK20.60024282
47BMPR20.59754463
48CDK190.56276093
49PAK10.55033965
50ZAP700.54945611
51RPS6KA50.52411806
52STK160.50937510
53WNK40.48486380
54ARAF0.47631281
55TAOK30.47532577
56ROCK10.46306344
57PAK60.45560417
58PRKCI0.43524118
59EIF2AK10.43495244
60IKBKB0.42009421
61PRKCQ0.41620273
62MAP3K110.40936369
63INSRR0.40261348
64EIF2AK30.39689277
65MOS0.38894062
66GRK60.38815834
67LYN0.35792497
68IGF1R0.34139282
69PIM20.33584595
70BCR0.32039049
71FYN0.31338975
72IKBKE0.31159170
73GRK50.31080972
74CSNK1A10.30442321
75ATR0.30346798
76WNK30.29994544
77CSNK2A10.27156490
78AKT30.26718050
79ERBB20.26187952
80INSR0.26088567
81SCYL20.24874261
82EIF2AK20.24613043
83TIE10.24432085
84STK390.24209563
85PRKCE0.23451980
86BRSK10.22877467
87PLK30.22802720
88ERBB30.22288680
89MAPK110.21262895
90RAF10.21239559
91CASK0.20763630
92PRKACA0.20611962
93MAPKAPK20.20560153
94PRKCA0.20524443
95CAMK2G0.19406528
96KIT0.19337822
97OBSCN0.19249778
98STK100.17439864
99PAK40.16466799
100OXSR10.16312669

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030506.76080206
2Primary immunodeficiency_Homo sapiens_hsa053404.74053782
3Oxidative phosphorylation_Homo sapiens_hsa001903.31746117
4Parkinsons disease_Homo sapiens_hsa050122.79567065
5Antigen processing and presentation_Homo sapiens_hsa046122.61455096
6Graft-versus-host disease_Homo sapiens_hsa053322.51132777
7Protein export_Homo sapiens_hsa030602.38475394
8RNA polymerase_Homo sapiens_hsa030202.30328542
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.05720877
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.03294137
11Alzheimers disease_Homo sapiens_hsa050101.78288044
12Huntingtons disease_Homo sapiens_hsa050161.71073606
13Autoimmune thyroid disease_Homo sapiens_hsa053201.69868140
14Fatty acid elongation_Homo sapiens_hsa000621.60081853
15Hematopoietic cell lineage_Homo sapiens_hsa046401.60040189
16Allograft rejection_Homo sapiens_hsa053301.51986272
17T cell receptor signaling pathway_Homo sapiens_hsa046601.51404010
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.50136944
19Phototransduction_Homo sapiens_hsa047441.49728709
20Sulfur metabolism_Homo sapiens_hsa009201.40457826
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.40362554
22Regulation of autophagy_Homo sapiens_hsa041401.39427122
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.29056025
24Type I diabetes mellitus_Homo sapiens_hsa049401.28807232
25Cardiac muscle contraction_Homo sapiens_hsa042601.27473194
26Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.21996699
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.20081732
28Shigellosis_Homo sapiens_hsa051311.18219590
29DNA replication_Homo sapiens_hsa030301.14262826
30Folate biosynthesis_Homo sapiens_hsa007901.13585908
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13438279
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.11842843
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11681653
34Asthma_Homo sapiens_hsa053101.08613546
35Pyrimidine metabolism_Homo sapiens_hsa002401.06730201
36Viral myocarditis_Homo sapiens_hsa054161.03474213
37Rheumatoid arthritis_Homo sapiens_hsa053231.01031086
38Peroxisome_Homo sapiens_hsa041460.98334335
39Steroid biosynthesis_Homo sapiens_hsa001000.97725717
40Ribosome_Homo sapiens_hsa030100.91830232
41Intestinal immune network for IgA production_Homo sapiens_hsa046720.91600820
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90596788
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90559222
44Sulfur relay system_Homo sapiens_hsa041220.89698546
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87488115
46Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85690148
47NF-kappa B signaling pathway_Homo sapiens_hsa040640.82894127
48Mismatch repair_Homo sapiens_hsa034300.81517356
49Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79705258
50Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.79029078
51RNA degradation_Homo sapiens_hsa030180.78802109
52Spliceosome_Homo sapiens_hsa030400.78504551
53Nitrogen metabolism_Homo sapiens_hsa009100.76970774
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73138255
55Collecting duct acid secretion_Homo sapiens_hsa049660.72798263
56Salmonella infection_Homo sapiens_hsa051320.70220061
57Measles_Homo sapiens_hsa051620.70003052
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69983375
59Base excision repair_Homo sapiens_hsa034100.68360219
60Homologous recombination_Homo sapiens_hsa034400.67746337
61Biosynthesis of amino acids_Homo sapiens_hsa012300.66841963
62Basal transcription factors_Homo sapiens_hsa030220.65214757
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65042273
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64966218
65Purine metabolism_Homo sapiens_hsa002300.63623860
66Caffeine metabolism_Homo sapiens_hsa002320.63203852
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62813122
68Propanoate metabolism_Homo sapiens_hsa006400.62562691
69Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.61176769
70Linoleic acid metabolism_Homo sapiens_hsa005910.60729337
71Carbon metabolism_Homo sapiens_hsa012000.59947006
72Vibrio cholerae infection_Homo sapiens_hsa051100.56870380
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.54363481
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54165505
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53226606
76Nucleotide excision repair_Homo sapiens_hsa034200.52337777
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49276092
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48481778
79Metabolic pathways_Homo sapiens_hsa011000.47544652
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47037696
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.44614846
82Herpes simplex infection_Homo sapiens_hsa051680.44040986
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39386459
84Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38967726
85Epstein-Barr virus infection_Homo sapiens_hsa051690.36974921
86Retinol metabolism_Homo sapiens_hsa008300.36945454
87RNA transport_Homo sapiens_hsa030130.36125196
88Taste transduction_Homo sapiens_hsa047420.35816466
89Systemic lupus erythematosus_Homo sapiens_hsa053220.35749864
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32101272
91Butanoate metabolism_Homo sapiens_hsa006500.31623990
92Salivary secretion_Homo sapiens_hsa049700.30561273
93Fatty acid metabolism_Homo sapiens_hsa012120.29784407
94Chemical carcinogenesis_Homo sapiens_hsa052040.25427232
95Morphine addiction_Homo sapiens_hsa050320.25354152
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24765490
97Legionellosis_Homo sapiens_hsa051340.24015723
98One carbon pool by folate_Homo sapiens_hsa006700.23480424
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.23203892
100Tryptophan metabolism_Homo sapiens_hsa003800.21633661

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »