

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proteasome assembly (GO:0043248) | 5.95490004 |
| 2 | maturation of 5.8S rRNA (GO:0000460) | 5.57560825 |
| 3 | signal peptide processing (GO:0006465) | 5.54023385 |
| 4 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.84748452 |
| 5 | retinal cone cell development (GO:0046549) | 4.84086639 |
| 6 | cullin deneddylation (GO:0010388) | 4.70444584 |
| 7 | regulation of cellular amino acid metabolic process (GO:0006521) | 4.66467579 |
| 8 | DNA strand renaturation (GO:0000733) | 4.55649316 |
| 9 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 4.52576509 |
| 10 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.50585017 |
| 11 | negative regulation of ligase activity (GO:0051352) | 4.49221333 |
| 12 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 4.49221333 |
| 13 | chaperone-mediated protein transport (GO:0072321) | 4.47863123 |
| 14 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 4.43004399 |
| 15 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 4.43004399 |
| 16 | regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139) | 4.40025285 |
| 17 | positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141) | 4.40025285 |
| 18 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 4.38802445 |
| 19 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 4.38446162 |
| 20 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 4.38446162 |
| 21 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 4.38446162 |
| 22 | mitochondrial RNA metabolic process (GO:0000959) | 4.31001431 |
| 23 | cellular response to leptin stimulus (GO:0044320) | 4.30073967 |
| 24 | ubiquinone biosynthetic process (GO:0006744) | 4.29176377 |
| 25 | protein deneddylation (GO:0000338) | 4.20540812 |
| 26 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 4.18408087 |
| 27 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 4.18408087 |
| 28 | fatty acid elongation (GO:0030497) | 4.15538930 |
| 29 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 4.11616853 |
| 30 | regulation of chronic inflammatory response (GO:0002676) | 4.10582723 |
| 31 | ribosome assembly (GO:0042255) | 4.09348635 |
| 32 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.99319950 |
| 33 | ubiquinone metabolic process (GO:0006743) | 3.97177461 |
| 34 | positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) | 3.81503632 |
| 35 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.77537501 |
| 36 | DNA deamination (GO:0045006) | 3.72500765 |
| 37 | response to leptin (GO:0044321) | 3.71182418 |
| 38 | GTP biosynthetic process (GO:0006183) | 3.68211836 |
| 39 | ATP hydrolysis coupled proton transport (GO:0015991) | 3.66455793 |
| 40 | energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988) | 3.66455793 |
| 41 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.61033716 |
| 42 | regulation of MHC class II biosynthetic process (GO:0045346) | 3.56561975 |
| 43 | protein targeting to mitochondrion (GO:0006626) | 3.56519565 |
| 44 | regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339 | 3.53888623 |
| 45 | rRNA modification (GO:0000154) | 3.53794280 |
| 46 | positive regulation of ligase activity (GO:0051351) | 3.52562129 |
| 47 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.48097997 |
| 48 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.47627183 |
| 49 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 3.46457202 |
| 50 | termination of RNA polymerase III transcription (GO:0006386) | 3.46417157 |
| 51 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.46417157 |
| 52 | regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) | 3.45114297 |
| 53 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.42248644 |
| 54 | quinone biosynthetic process (GO:1901663) | 3.38655207 |
| 55 | regulation of cellular amine metabolic process (GO:0033238) | 3.37133165 |
| 56 | UTP biosynthetic process (GO:0006228) | 3.33688760 |
| 57 | DNA damage response, detection of DNA damage (GO:0042769) | 3.32313366 |
| 58 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.31967736 |
| 59 | glial cell proliferation (GO:0014009) | 3.31842549 |
| 60 | spliceosomal snRNP assembly (GO:0000387) | 3.28477851 |
| 61 | lysine catabolic process (GO:0006554) | 3.27953956 |
| 62 | lysine metabolic process (GO:0006553) | 3.27953956 |
| 63 | respiratory electron transport chain (GO:0022904) | 3.26263693 |
| 64 | 7-methylguanosine mRNA capping (GO:0006370) | 3.26182400 |
| 65 | positive regulation of cell cycle arrest (GO:0071158) | 3.25769269 |
| 66 | response to misfolded protein (GO:0051788) | 3.25084537 |
| 67 | establishment of protein localization to mitochondrion (GO:0072655) | 3.24498103 |
| 68 | regulation of isotype switching to IgG isotypes (GO:0048302) | 3.22739775 |
| 69 | protein localization to mitochondrion (GO:0070585) | 3.21705533 |
| 70 | electron transport chain (GO:0022900) | 3.18111320 |
| 71 | rRNA methylation (GO:0031167) | 3.17484769 |
| 72 | RNA capping (GO:0036260) | 3.17168523 |
| 73 | 7-methylguanosine RNA capping (GO:0009452) | 3.17168523 |
| 74 | replication fork processing (GO:0031297) | 3.16342675 |
| 75 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.15484115 |
| 76 | regulation of cardiac muscle cell contraction (GO:0086004) | 3.12887998 |
| 77 | regulation of ligase activity (GO:0051340) | 3.12856428 |
| 78 | tRNA aminoacylation (GO:0043039) | 3.10028304 |
| 79 | amino acid activation (GO:0043038) | 3.10028304 |
| 80 | positive regulation of chemokine biosynthetic process (GO:0045080) | 3.07546468 |
| 81 | pseudouridine synthesis (GO:0001522) | 3.06649734 |
| 82 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.05273261 |
| 83 | ATP synthesis coupled proton transport (GO:0015986) | 3.05273261 |
| 84 | tetrahydrofolate metabolic process (GO:0046653) | 3.02795245 |
| 85 | signal transduction in response to DNA damage (GO:0042770) | 2.99146544 |
| 86 | negative regulation of protein ubiquitination (GO:0031397) | 2.97713492 |
| 87 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.94680657 |
| 88 | negative regulation of growth of symbiont in host (GO:0044130) | 2.94096128 |
| 89 | negative regulation of growth of symbiont involved in interaction with host (GO:0044146) | 2.94096128 |
| 90 | modulation of growth of symbiont involved in interaction with host (GO:0044144) | 2.94096128 |
| 91 | regulation of growth of symbiont in host (GO:0044126) | 2.94096128 |
| 92 | protein complex biogenesis (GO:0070271) | 2.93477915 |
| 93 | regulation of relaxation of muscle (GO:1901077) | 2.93461993 |
| 94 | coenzyme catabolic process (GO:0009109) | 2.93165876 |
| 95 | UTP metabolic process (GO:0046051) | 2.93124541 |
| 96 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.92329788 |
| 97 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 2.91439137 |
| 98 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 2.91439137 |
| 99 | NADH dehydrogenase complex assembly (GO:0010257) | 2.91439137 |
| 100 | tRNA aminoacylation for protein translation (GO:0006418) | 2.89872491 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 5.65760422 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.40053788 |
| 3 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.86206593 |
| 4 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.69152617 |
| 5 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 4.24270625 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.76797213 |
| 7 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.53584705 |
| 8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.43412264 |
| 9 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.34666442 |
| 10 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.16121418 |
| 11 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.00467402 |
| 12 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.70869691 |
| 13 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 2.56617219 |
| 14 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.52944741 |
| 15 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.47887285 |
| 16 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 2.47490178 |
| 17 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.43326698 |
| 18 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.42910585 |
| 19 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.40810382 |
| 20 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.40741797 |
| 21 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.36781621 |
| 22 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.24465021 |
| 23 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.17326346 |
| 24 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.06795586 |
| 25 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 2.05091160 |
| 26 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.02918080 |
| 27 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.01570056 |
| 28 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.93396391 |
| 29 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 1.92791105 |
| 30 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.90899227 |
| 31 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.89781015 |
| 32 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.81010677 |
| 33 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.75571437 |
| 34 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 1.68622256 |
| 35 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.67168775 |
| 36 | VDR_22108803_ChIP-Seq_LS180_Human | 1.63542744 |
| 37 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.62830300 |
| 38 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.61633391 |
| 39 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.60966195 |
| 40 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.60445004 |
| 41 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.58703400 |
| 42 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.58700836 |
| 43 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.54801000 |
| 44 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.54480627 |
| 45 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.53199960 |
| 46 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.47493547 |
| 47 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.47220621 |
| 48 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.46557543 |
| 49 | FUS_26573619_Chip-Seq_HEK293_Human | 1.41395449 |
| 50 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.35310525 |
| 51 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.23627666 |
| 52 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.22707531 |
| 53 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.22570025 |
| 54 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 1.21045391 |
| 55 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.19725853 |
| 56 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.19380894 |
| 57 | ERG_20517297_ChIP-Seq_VCAP_Human | 1.13163466 |
| 58 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.10707950 |
| 59 | IRF1_19129219_ChIP-ChIP_H3396_Human | 1.10440795 |
| 60 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 1.10402187 |
| 61 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.08862127 |
| 62 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.06945555 |
| 63 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.06235365 |
| 64 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.04766884 |
| 65 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.04687075 |
| 66 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.04260499 |
| 67 | EWS_26573619_Chip-Seq_HEK293_Human | 1.03315574 |
| 68 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.02812281 |
| 69 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.01939849 |
| 70 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.01906600 |
| 71 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.01229392 |
| 72 | CIITA_25753668_ChIP-Seq_RAJI_Human | 0.98120645 |
| 73 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 0.97997579 |
| 74 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.97264108 |
| 75 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.95970631 |
| 76 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 0.95573153 |
| 77 | AR_20517297_ChIP-Seq_VCAP_Human | 0.95402009 |
| 78 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.93124226 |
| 79 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 0.90763911 |
| 80 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.90548365 |
| 81 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.88217313 |
| 82 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.85622233 |
| 83 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.85142138 |
| 84 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.81993265 |
| 85 | SALL4_22934838_ChIP-ChIP_CD34+_Human | 0.80650822 |
| 86 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.79765224 |
| 87 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 0.75912421 |
| 88 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.75867266 |
| 89 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.75425686 |
| 90 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.75239969 |
| 91 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 0.73211063 |
| 92 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.72165128 |
| 93 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.71947572 |
| 94 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 0.71781372 |
| 95 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 0.71607053 |
| 96 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.71253924 |
| 97 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 0.71080055 |
| 98 | HOXB7_26014856_ChIP-Seq_BT474_Human | 0.68965740 |
| 99 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.68769122 |
| 100 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 0.67487355 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003136_yellow_coat_color | 6.31824117 |
| 2 | MP0001873_stomach_inflammation | 4.12109874 |
| 3 | MP0001661_extended_life_span | 3.85444218 |
| 4 | MP0008058_abnormal_DNA_repair | 3.35201251 |
| 5 | MP0000579_abnormal_nail_morphology | 3.06845943 |
| 6 | MP0003950_abnormal_plasma_membrane | 2.86890843 |
| 7 | MP0002638_abnormal_pupillary_reflex | 2.65304085 |
| 8 | MP0002736_abnormal_nociception_after | 2.54003982 |
| 9 | MP0005423_abnormal_somatic_nervous | 2.30137469 |
| 10 | MP0003186_abnormal_redox_activity | 2.22270823 |
| 11 | MP0005551_abnormal_eye_electrophysiolog | 2.21858760 |
| 12 | MP0001853_heart_inflammation | 2.19531564 |
| 13 | MP0003011_delayed_dark_adaptation | 2.13168637 |
| 14 | MP0005275_abnormal_skin_tensile | 2.11923115 |
| 15 | MP0001835_abnormal_antigen_presentation | 2.02039660 |
| 16 | MP0001502_abnormal_circadian_rhythm | 1.94710711 |
| 17 | MP0001984_abnormal_olfaction | 1.92737505 |
| 18 | MP0005253_abnormal_eye_physiology | 1.91756517 |
| 19 | MP0004782_abnormal_surfactant_physiolog | 1.89478636 |
| 20 | MP0001968_abnormal_touch/_nociception | 1.89096202 |
| 21 | MP0001905_abnormal_dopamine_level | 1.87799479 |
| 22 | MP0003693_abnormal_embryo_hatching | 1.85479411 |
| 23 | MP0000685_abnormal_immune_system | 1.84530296 |
| 24 | MP0004381_abnormal_hair_follicle | 1.83177594 |
| 25 | MP0000647_abnormal_sebaceous_gland | 1.76564913 |
| 26 | MP0002938_white_spotting | 1.71540832 |
| 27 | MP0003880_abnormal_central_pattern | 1.69370976 |
| 28 | MP0003718_maternal_effect | 1.63368900 |
| 29 | MP0000427_abnormal_hair_cycle | 1.61722243 |
| 30 | MP0006072_abnormal_retinal_apoptosis | 1.61495174 |
| 31 | MP0004145_abnormal_muscle_electrophysio | 1.57565182 |
| 32 | MP0000383_abnormal_hair_follicle | 1.55997521 |
| 33 | MP0005075_abnormal_melanosome_morpholog | 1.54161611 |
| 34 | MP0002095_abnormal_skin_pigmentation | 1.50637855 |
| 35 | MP0009697_abnormal_copulation | 1.50149464 |
| 36 | MP0003646_muscle_fatigue | 1.46469148 |
| 37 | MP0004957_abnormal_blastocyst_morpholog | 1.44824997 |
| 38 | MP0005410_abnormal_fertilization | 1.42035284 |
| 39 | MP0005671_abnormal_response_to | 1.39367291 |
| 40 | MP0002102_abnormal_ear_morphology | 1.34501641 |
| 41 | MP0008875_abnormal_xenobiotic_pharmacok | 1.31777427 |
| 42 | MP0003111_abnormal_nucleus_morphology | 1.30330907 |
| 43 | MP0001529_abnormal_vocalization | 1.26143117 |
| 44 | MP0001348_abnormal_lacrimal_gland | 1.22865645 |
| 45 | MP0010094_abnormal_chromosome_stability | 1.21660121 |
| 46 | MP0006035_abnormal_mitochondrial_morpho | 1.18283278 |
| 47 | MP0003329_amyloid_beta_deposits | 1.15802588 |
| 48 | MP0001501_abnormal_sleep_pattern | 1.14617915 |
| 49 | MP0002405_respiratory_system_inflammati | 1.14098230 |
| 50 | MP0008007_abnormal_cellular_replicative | 1.13077578 |
| 51 | MP0005310_abnormal_salivary_gland | 1.12625613 |
| 52 | MP0006036_abnormal_mitochondrial_physio | 1.06463158 |
| 53 | MP0008932_abnormal_embryonic_tissue | 1.04916305 |
| 54 | MP0002132_abnormal_respiratory_system | 1.02590426 |
| 55 | MP0004043_abnormal_pH_regulation | 1.02025160 |
| 56 | MP0001986_abnormal_taste_sensitivity | 0.99355635 |
| 57 | MP0009764_decreased_sensitivity_to | 0.98682485 |
| 58 | MP0001727_abnormal_embryo_implantation | 0.96857737 |
| 59 | MP0002090_abnormal_vision | 0.96376358 |
| 60 | MP0003252_abnormal_bile_duct | 0.95280640 |
| 61 | MP0009053_abnormal_anal_canal | 0.94570622 |
| 62 | MP0003195_calcinosis | 0.93431812 |
| 63 | MP0003786_premature_aging | 0.92589248 |
| 64 | MP0009785_altered_susceptibility_to | 0.92503221 |
| 65 | MP0008770_decreased_survivor_rate | 0.90169697 |
| 66 | MP0002822_catalepsy | 0.88777845 |
| 67 | MP0003941_abnormal_skin_development | 0.86035806 |
| 68 | MP0002751_abnormal_autonomic_nervous | 0.85901834 |
| 69 | MP0002148_abnormal_hypersensitivity_rea | 0.85648295 |
| 70 | MP0002734_abnormal_mechanical_nocicepti | 0.85046490 |
| 71 | MP0005332_abnormal_amino_acid | 0.83955865 |
| 72 | MP0008260_abnormal_autophagy | 0.83635166 |
| 73 | MP0001243_abnormal_dermal_layer | 0.83040149 |
| 74 | MP0001764_abnormal_homeostasis | 0.81461289 |
| 75 | MP0002254_reproductive_system_inflammat | 0.80390371 |
| 76 | MP0008872_abnormal_physiological_respon | 0.77918490 |
| 77 | MP0010307_abnormal_tumor_latency | 0.77350671 |
| 78 | MP0008569_lethality_at_weaning | 0.76653595 |
| 79 | MP0009333_abnormal_splenocyte_physiolog | 0.75726781 |
| 80 | MP0003077_abnormal_cell_cycle | 0.73475390 |
| 81 | MP0004142_abnormal_muscle_tone | 0.71696298 |
| 82 | MP0002396_abnormal_hematopoietic_system | 0.67185679 |
| 83 | MP0010771_integument_phenotype | 0.66705774 |
| 84 | MP0001919_abnormal_reproductive_system | 0.66046334 |
| 85 | MP0000751_myopathy | 0.65382435 |
| 86 | MP0000749_muscle_degeneration | 0.63265482 |
| 87 | MP0001324_abnormal_eye_pigmentation | 0.62734753 |
| 88 | MP0001970_abnormal_pain_threshold | 0.62596978 |
| 89 | MP0002272_abnormal_nervous_system | 0.62130673 |
| 90 | MP0002653_abnormal_ependyma_morphology | 0.61320802 |
| 91 | MP0001958_emphysema | 0.60742351 |
| 92 | MP0002210_abnormal_sex_determination | 0.60356753 |
| 93 | MP0004215_abnormal_myocardial_fiber | 0.58935615 |
| 94 | MP0001929_abnormal_gametogenesis | 0.58831107 |
| 95 | MP0003806_abnormal_nucleotide_metabolis | 0.58427547 |
| 96 | MP0005636_abnormal_mineral_homeostasis | 0.56685892 |
| 97 | MP0008789_abnormal_olfactory_epithelium | 0.55666847 |
| 98 | MP0008873_increased_physiological_sensi | 0.54298935 |
| 99 | MP0004859_abnormal_synaptic_plasticity | 0.54203517 |
| 100 | MP0005171_absent_coat_pigmentation | 0.53796999 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Follicular hyperkeratosis (HP:0007502) | 5.19973661 |
| 2 | Congenital, generalized hypertrichosis (HP:0004540) | 4.91360518 |
| 3 | Acute necrotizing encephalopathy (HP:0006965) | 4.71191042 |
| 4 | Pili torti (HP:0003777) | 4.50978309 |
| 5 | Hepatocellular necrosis (HP:0001404) | 4.49405253 |
| 6 | Methylmalonic acidemia (HP:0002912) | 4.48240915 |
| 7 | Acute encephalopathy (HP:0006846) | 4.34772026 |
| 8 | Methylmalonic aciduria (HP:0012120) | 4.34184114 |
| 9 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.29746950 |
| 10 | Hepatic necrosis (HP:0002605) | 4.28740330 |
| 11 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 4.12319879 |
| 12 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 4.12319879 |
| 13 | Large for gestational age (HP:0001520) | 4.10932907 |
| 14 | Mitochondrial inheritance (HP:0001427) | 4.05798684 |
| 15 | Increased CSF lactate (HP:0002490) | 4.03299479 |
| 16 | Progressive macrocephaly (HP:0004481) | 3.65975505 |
| 17 | Duplicated collecting system (HP:0000081) | 3.52547662 |
| 18 | Abnormality of the pons (HP:0007361) | 3.50779625 |
| 19 | Neonatal respiratory distress (HP:0002643) | 3.36266467 |
| 20 | Increased serum lactate (HP:0002151) | 3.34093987 |
| 21 | Hypoglycemic coma (HP:0001325) | 3.32163164 |
| 22 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.16028395 |
| 23 | Increased hepatocellular lipid droplets (HP:0006565) | 3.15950781 |
| 24 | Microvesicular hepatic steatosis (HP:0001414) | 3.06748111 |
| 25 | Abnormality of the renal collecting system (HP:0004742) | 3.04181163 |
| 26 | Cerebral edema (HP:0002181) | 3.01867060 |
| 27 | Abnormality of homocysteine metabolism (HP:0010919) | 3.01774172 |
| 28 | Homocystinuria (HP:0002156) | 3.01774172 |
| 29 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 3.00402366 |
| 30 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.90139817 |
| 31 | Degeneration of anterior horn cells (HP:0002398) | 2.89927646 |
| 32 | Abnormality of the anterior horn cell (HP:0006802) | 2.89927646 |
| 33 | Abnormality of methionine metabolism (HP:0010901) | 2.89226332 |
| 34 | Exercise intolerance (HP:0003546) | 2.88746290 |
| 35 | Abnormal hair laboratory examination (HP:0003328) | 2.87772494 |
| 36 | Sparse eyelashes (HP:0000653) | 2.80923444 |
| 37 | Lipid accumulation in hepatocytes (HP:0006561) | 2.80192998 |
| 38 | CNS demyelination (HP:0007305) | 2.80082858 |
| 39 | Lactic acidosis (HP:0003128) | 2.79663145 |
| 40 | Ketoacidosis (HP:0001993) | 2.78485741 |
| 41 | Abnormality of vitamin B metabolism (HP:0004340) | 2.73589432 |
| 42 | Cerebral hypomyelination (HP:0006808) | 2.72112891 |
| 43 | CNS hypomyelination (HP:0003429) | 2.69540754 |
| 44 | Lethargy (HP:0001254) | 2.64299428 |
| 45 | Dicarboxylic aciduria (HP:0003215) | 2.57469042 |
| 46 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.57469042 |
| 47 | Respiratory failure (HP:0002878) | 2.57026769 |
| 48 | Optic disc pallor (HP:0000543) | 2.49505158 |
| 49 | Thyroid-stimulating hormone excess (HP:0002925) | 2.46397428 |
| 50 | Oral leukoplakia (HP:0002745) | 2.40037370 |
| 51 | Medial flaring of the eyebrow (HP:0010747) | 2.37823685 |
| 52 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.34536523 |
| 53 | Brittle hair (HP:0002299) | 2.33261602 |
| 54 | Type I transferrin isoform profile (HP:0003642) | 2.27938482 |
| 55 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.26470315 |
| 56 | Hyperglycinemia (HP:0002154) | 2.23000337 |
| 57 | Emotional lability (HP:0000712) | 2.21912466 |
| 58 | Hypoglycemic seizures (HP:0002173) | 2.21188154 |
| 59 | Leukodystrophy (HP:0002415) | 2.19420604 |
| 60 | Action tremor (HP:0002345) | 2.15893583 |
| 61 | Generalized aminoaciduria (HP:0002909) | 2.14700897 |
| 62 | Aplasia/Hypoplasia of the 5th finger (HP:0006262) | 2.14203844 |
| 63 | Spastic tetraparesis (HP:0001285) | 2.13675921 |
| 64 | Woolly hair (HP:0002224) | 2.13320258 |
| 65 | 3-Methylglutaconic aciduria (HP:0003535) | 2.12435691 |
| 66 | Pancytopenia (HP:0001876) | 2.06073060 |
| 67 | Reticulocytopenia (HP:0001896) | 2.05190530 |
| 68 | Premature ovarian failure (HP:0008209) | 2.02768385 |
| 69 | Ulnar claw (HP:0001178) | 2.02319392 |
| 70 | Respiratory difficulties (HP:0002880) | 1.99915044 |
| 71 | Abnormal number of erythroid precursors (HP:0012131) | 1.98973785 |
| 72 | Blindness (HP:0000618) | 1.97726683 |
| 73 | Hyperglycinuria (HP:0003108) | 1.97550227 |
| 74 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 1.96143569 |
| 75 | Renal Fanconi syndrome (HP:0001994) | 1.95776365 |
| 76 | Hypoplasia of the pons (HP:0012110) | 1.95045568 |
| 77 | Increased intramyocellular lipid droplets (HP:0012240) | 1.93282082 |
| 78 | Progressive inability to walk (HP:0002505) | 1.92178508 |
| 79 | Ragged-red muscle fibers (HP:0003200) | 1.92154897 |
| 80 | Exercise-induced muscle cramps (HP:0003710) | 1.89828900 |
| 81 | Cellular immunodeficiency (HP:0005374) | 1.88425179 |
| 82 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.85988116 |
| 83 | Abnormality of glycine metabolism (HP:0010895) | 1.85988116 |
| 84 | Hyperinsulinemic hypoglycemia (HP:0000825) | 1.85222892 |
| 85 | Short 5th finger (HP:0009237) | 1.83094724 |
| 86 | Chronic bronchitis (HP:0004469) | 1.80784842 |
| 87 | Ketosis (HP:0001946) | 1.80485968 |
| 88 | Abnormality of urine glucose concentration (HP:0011016) | 1.78953863 |
| 89 | Glycosuria (HP:0003076) | 1.78953863 |
| 90 | Ureteral duplication (HP:0000073) | 1.78368275 |
| 91 | Inability to walk (HP:0002540) | 1.77500180 |
| 92 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 1.75801937 |
| 93 | Gliosis (HP:0002171) | 1.74159504 |
| 94 | Gait imbalance (HP:0002141) | 1.71759815 |
| 95 | Congenital primary aphakia (HP:0007707) | 1.70393066 |
| 96 | Abnormality of serum amino acid levels (HP:0003112) | 1.69862116 |
| 97 | Absent epiphyses (HP:0010577) | 1.68301522 |
| 98 | Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003) | 1.68301522 |
| 99 | Attenuation of retinal blood vessels (HP:0007843) | 1.67932337 |
| 100 | Postnatal microcephaly (HP:0005484) | 1.67238111 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NME1 | 3.30414309 |
| 2 | NEK6 | 2.84626943 |
| 3 | VRK2 | 2.79558171 |
| 4 | TSSK6 | 2.77541145 |
| 5 | TXK | 2.67809792 |
| 6 | STK16 | 2.63075606 |
| 7 | MKNK2 | 2.50804245 |
| 8 | EIF2AK3 | 2.35513062 |
| 9 | MKNK1 | 2.16584311 |
| 10 | BMPR1B | 2.07703180 |
| 11 | PDK2 | 10.8898948 |
| 12 | BUB1 | 1.98630108 |
| 13 | TRIM28 | 1.95086583 |
| 14 | NEK1 | 1.87276081 |
| 15 | CCNB1 | 1.81116191 |
| 16 | SRPK1 | 1.76994584 |
| 17 | MAPKAPK3 | 1.75856823 |
| 18 | PBK | 1.65610383 |
| 19 | TLK1 | 1.51075717 |
| 20 | VRK1 | 1.45703027 |
| 21 | EIF2AK1 | 1.25611433 |
| 22 | MST4 | 1.15525181 |
| 23 | NUAK1 | 1.12779444 |
| 24 | PASK | 1.10059094 |
| 25 | NTRK2 | 1.08823691 |
| 26 | BCKDK | 1.06283578 |
| 27 | MAPK7 | 0.95516004 |
| 28 | WNK3 | 0.92602083 |
| 29 | ADRBK2 | 0.91617347 |
| 30 | PLK3 | 0.90323654 |
| 31 | PKN2 | 0.88719267 |
| 32 | GRK1 | 0.86839558 |
| 33 | PINK1 | 0.85050771 |
| 34 | PLK4 | 0.84700287 |
| 35 | MAPK12 | 0.83369145 |
| 36 | PRKCG | 0.79809064 |
| 37 | EIF2AK2 | 0.79665930 |
| 38 | ZAK | 0.78805002 |
| 39 | WNK4 | 0.76970038 |
| 40 | BCR | 0.75408781 |
| 41 | PIM2 | 0.75036113 |
| 42 | ALK | 0.74579284 |
| 43 | DAPK1 | 0.64735612 |
| 44 | PHKG1 | 0.57881831 |
| 45 | PHKG2 | 0.57881831 |
| 46 | FGFR1 | 0.54907811 |
| 47 | DYRK1A | 0.54357553 |
| 48 | MAPKAPK5 | 0.54351259 |
| 49 | MAP4K2 | 0.54157468 |
| 50 | TTK | 0.54119437 |
| 51 | RPS6KA5 | 0.53696994 |
| 52 | CSNK1G1 | 0.52203642 |
| 53 | TEC | 0.48685255 |
| 54 | TGFBR1 | 0.48140045 |
| 55 | FGR | 0.46116557 |
| 56 | CDK8 | 0.43699765 |
| 57 | STK4 | 0.42663969 |
| 58 | FLT3 | 0.41436206 |
| 59 | FRK | 0.41162531 |
| 60 | NME2 | 0.38991854 |
| 61 | PRKG2 | 0.38796092 |
| 62 | PLK2 | 0.38374626 |
| 63 | INSRR | 0.38136192 |
| 64 | PLK1 | 0.36550534 |
| 65 | STK39 | 0.35872881 |
| 66 | BRD4 | 0.35841309 |
| 67 | PTK2B | 0.35816418 |
| 68 | PRKCI | 0.35621492 |
| 69 | MUSK | 0.35044775 |
| 70 | CSNK1G3 | 0.34949805 |
| 71 | DYRK2 | 0.33394181 |
| 72 | CSNK1A1L | 0.32629929 |
| 73 | PAK3 | 0.32070379 |
| 74 | CDC7 | 0.31925006 |
| 75 | SIK3 | 0.31211181 |
| 76 | CSNK2A2 | 0.29697351 |
| 77 | STK38 | 0.28903395 |
| 78 | PDK1 | 0.28104228 |
| 79 | ATR | 0.27874114 |
| 80 | AURKA | 0.26014956 |
| 81 | PIK3CA | 0.24959052 |
| 82 | CAMK2A | 0.23921786 |
| 83 | PRKCH | 0.23627419 |
| 84 | CSNK1E | 0.21997693 |
| 85 | ADRBK1 | 0.21643760 |
| 86 | CSNK2A1 | 0.21464094 |
| 87 | PRKACA | 0.20259728 |
| 88 | CSNK1A1 | 0.20031937 |
| 89 | MAP3K9 | 0.19603951 |
| 90 | MARK3 | 0.17404292 |
| 91 | ERBB4 | 0.17190010 |
| 92 | PRKCE | 0.17144708 |
| 93 | PDPK1 | 0.16539722 |
| 94 | TESK2 | 0.16520936 |
| 95 | TIE1 | 0.16284730 |
| 96 | PAK6 | 0.15972479 |
| 97 | PRKCA | 0.14910171 |
| 98 | MAP3K4 | 0.14896260 |
| 99 | PRKACG | 0.14782471 |
| 100 | LRRK2 | 0.14189948 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 5.93019906 |
| 2 | RNA polymerase_Homo sapiens_hsa03020 | 3.34097845 |
| 3 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 3.24529710 |
| 4 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.15296179 |
| 5 | Protein export_Homo sapiens_hsa03060 | 2.68859822 |
| 6 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.67173759 |
| 7 | Parkinsons disease_Homo sapiens_hsa05012 | 2.42299189 |
| 8 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.39802561 |
| 9 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.37277264 |
| 10 | Propanoate metabolism_Homo sapiens_hsa00640 | 2.30561928 |
| 11 | Fatty acid elongation_Homo sapiens_hsa00062 | 2.29976720 |
| 12 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 2.11572838 |
| 13 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.07663407 |
| 14 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 2.06605984 |
| 15 | Pyruvate metabolism_Homo sapiens_hsa00620 | 2.04438072 |
| 16 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.98593865 |
| 17 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.89253135 |
| 18 | Ribosome_Homo sapiens_hsa03010 | 1.78321652 |
| 19 | Huntingtons disease_Homo sapiens_hsa05016 | 1.75084898 |
| 20 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.59305997 |
| 21 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.56583326 |
| 22 | Alzheimers disease_Homo sapiens_hsa05010 | 1.55572848 |
| 23 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.54676501 |
| 24 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.44765787 |
| 25 | Basal transcription factors_Homo sapiens_hsa03022 | 1.35566024 |
| 26 | Mismatch repair_Homo sapiens_hsa03430 | 1.34508816 |
| 27 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.34435527 |
| 28 | Purine metabolism_Homo sapiens_hsa00230 | 1.34214921 |
| 29 | RNA degradation_Homo sapiens_hsa03018 | 1.34142528 |
| 30 | Spliceosome_Homo sapiens_hsa03040 | 1.33648154 |
| 31 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.30879854 |
| 32 | Homologous recombination_Homo sapiens_hsa03440 | 1.22535362 |
| 33 | RNA transport_Homo sapiens_hsa03013 | 1.21701401 |
| 34 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.19002910 |
| 35 | Carbon metabolism_Homo sapiens_hsa01200 | 1.17455961 |
| 36 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.15303648 |
| 37 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.12569329 |
| 38 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.06028972 |
| 39 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.04109474 |
| 40 | Regulation of autophagy_Homo sapiens_hsa04140 | 1.02418718 |
| 41 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.01136638 |
| 42 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.97413650 |
| 43 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.95706036 |
| 44 | Peroxisome_Homo sapiens_hsa04146 | 0.93059600 |
| 45 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.88498867 |
| 46 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.88051014 |
| 47 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.86474989 |
| 48 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.85439240 |
| 49 | DNA replication_Homo sapiens_hsa03030 | 0.83413809 |
| 50 | Metabolic pathways_Homo sapiens_hsa01100 | 0.79789984 |
| 51 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.77218967 |
| 52 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.76792835 |
| 53 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.76615956 |
| 54 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.75067896 |
| 55 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.74630915 |
| 56 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.68174419 |
| 57 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.67986141 |
| 58 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.65929846 |
| 59 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.65670665 |
| 60 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.63200224 |
| 61 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.62983912 |
| 62 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.62571164 |
| 63 | ABC transporters_Homo sapiens_hsa02010 | 0.62100017 |
| 64 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.58855429 |
| 65 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.58077168 |
| 66 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.55249210 |
| 67 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.53798103 |
| 68 | Olfactory transduction_Homo sapiens_hsa04740 | 0.53574207 |
| 69 | Phototransduction_Homo sapiens_hsa04744 | 0.51907875 |
| 70 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.50656342 |
| 71 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.50234282 |
| 72 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.45208903 |
| 73 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.39071724 |
| 74 | Histidine metabolism_Homo sapiens_hsa00340 | 0.38079826 |
| 75 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.37937141 |
| 76 | Asthma_Homo sapiens_hsa05310 | 0.37161219 |
| 77 | Lysine degradation_Homo sapiens_hsa00310 | 0.35701741 |
| 78 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.35025621 |
| 79 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.33855816 |
| 80 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.32952308 |
| 81 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.32947562 |
| 82 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.32805529 |
| 83 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.31431155 |
| 84 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.30432026 |
| 85 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.30338982 |
| 86 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.29873354 |
| 87 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.28879351 |
| 88 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.28835077 |
| 89 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.28823702 |
| 90 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.27976443 |
| 91 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.27498562 |
| 92 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.26470851 |
| 93 | Base excision repair_Homo sapiens_hsa03410 | 0.24262181 |
| 94 | Sulfur relay system_Homo sapiens_hsa04122 | 0.22924557 |
| 95 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.20737753 |
| 96 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.19882707 |
| 97 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.19614821 |
| 98 | Jak-STAT signaling pathway_Homo sapiens_hsa04630 | 0.18884316 |
| 99 | Allograft rejection_Homo sapiens_hsa05330 | 0.18675253 |
| 100 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.17403097 |

