PGAM1P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.76700216
2DNA deamination (GO:0045006)4.71531694
3platelet dense granule organization (GO:0060155)4.02316039
4response to pheromone (GO:0019236)3.99750620
5L-fucose catabolic process (GO:0042355)3.91432163
6fucose catabolic process (GO:0019317)3.91432163
7L-fucose metabolic process (GO:0042354)3.91432163
8protein complex biogenesis (GO:0070271)3.71425432
9protein-cofactor linkage (GO:0018065)3.68334501
10mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.67925968
11detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.66620935
12respiratory chain complex IV assembly (GO:0008535)3.64695815
13water-soluble vitamin biosynthetic process (GO:0042364)3.56755568
14mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.56622559
15mitochondrial respiratory chain complex I assembly (GO:0032981)3.56622559
16NADH dehydrogenase complex assembly (GO:0010257)3.56622559
17negative regulation of telomere maintenance (GO:0032205)3.50602548
18mitochondrial respiratory chain complex assembly (GO:0033108)3.46874070
19nonmotile primary cilium assembly (GO:0035058)3.46111797
20indolalkylamine metabolic process (GO:0006586)3.45168648
21regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.39378466
22energy coupled proton transport, down electrochemical gradient (GO:0015985)3.38493083
23ATP synthesis coupled proton transport (GO:0015986)3.38493083
24establishment of protein localization to mitochondrial membrane (GO:0090151)3.34675130
25nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.31588533
26cytidine deamination (GO:0009972)3.22458984
27cytidine metabolic process (GO:0046087)3.22458984
28cytidine catabolic process (GO:0006216)3.22458984
29cytochrome complex assembly (GO:0017004)3.21589511
30somite development (GO:0061053)3.16676045
31exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.12964813
32positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.12626166
33regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.08322608
34regulation of cilium movement (GO:0003352)3.08028135
35tryptophan catabolic process (GO:0006569)3.07705573
36indole-containing compound catabolic process (GO:0042436)3.07705573
37indolalkylamine catabolic process (GO:0046218)3.07705573
38epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.06952383
39kynurenine metabolic process (GO:0070189)3.04587614
40rRNA modification (GO:0000154)3.03347016
41negative regulation of DNA-dependent DNA replication (GO:2000104)3.02480882
42epithelial cilium movement (GO:0003351)3.02371397
43mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.99780846
44S-adenosylmethionine metabolic process (GO:0046500)2.93363025
45protein neddylation (GO:0045116)2.92816222
46rRNA methylation (GO:0031167)2.92816185
47preassembly of GPI anchor in ER membrane (GO:0016254)2.88270139
48proteasome assembly (GO:0043248)2.87826790
49piRNA metabolic process (GO:0034587)2.87113368
50protein polyglutamylation (GO:0018095)2.86381613
51regulation of nuclear cell cycle DNA replication (GO:0033262)2.85507628
52RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.85028202
53tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.85028202
54cilium morphogenesis (GO:0060271)2.83087256
55behavioral response to ethanol (GO:0048149)2.80101905
56tryptophan metabolic process (GO:0006568)2.75715821
57mannosylation (GO:0097502)2.75197908
58negative regulation of cytosolic calcium ion concentration (GO:0051481)2.73752908
59retinal cone cell development (GO:0046549)2.71798511
60maturation of 5.8S rRNA (GO:0000460)2.70413232
61pyrimidine nucleobase catabolic process (GO:0006208)2.70044981
62electron transport chain (GO:0022900)2.69229666
63pyrimidine ribonucleoside catabolic process (GO:0046133)2.68644697
64dopamine transport (GO:0015872)2.68444065
65regulation of telomere maintenance (GO:0032204)2.66046557
66photoreceptor cell maintenance (GO:0045494)2.64967988
67respiratory electron transport chain (GO:0022904)2.64813612
68L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.64590073
69tRNA processing (GO:0008033)2.64030394
70DNA double-strand break processing (GO:0000729)2.62705750
71regulation of glucokinase activity (GO:0033131)2.61233253
72regulation of hexokinase activity (GO:1903299)2.61233253
73chaperone-mediated protein transport (GO:0072321)2.60972140
74transcription elongation from RNA polymerase III promoter (GO:0006385)2.58290322
75termination of RNA polymerase III transcription (GO:0006386)2.58290322
76nephron tubule morphogenesis (GO:0072078)2.58204323
77nephron epithelium morphogenesis (GO:0072088)2.58204323
78neural tube formation (GO:0001841)2.57184063
79somatic hypermutation of immunoglobulin genes (GO:0016446)2.55959621
80somatic diversification of immune receptors via somatic mutation (GO:0002566)2.55959621
81negative regulation of transcription regulatory region DNA binding (GO:2000678)2.52695998
82inner mitochondrial membrane organization (GO:0007007)2.51990528
83negative regulation of translation, ncRNA-mediated (GO:0040033)2.51941385
84regulation of translation, ncRNA-mediated (GO:0045974)2.51941385
85negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.51941385
86regulation of mitotic spindle checkpoint (GO:1903504)2.51676942
87regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.51676942
88ubiquinone biosynthetic process (GO:0006744)2.50389123
89regulation of posttranscriptional gene silencing (GO:0060147)2.49080956
90regulation of gene silencing by miRNA (GO:0060964)2.49080956
91regulation of gene silencing by RNA (GO:0060966)2.49080956
92indole-containing compound metabolic process (GO:0042430)2.48532062
93opioid receptor signaling pathway (GO:0038003)2.47212013
94cilium organization (GO:0044782)2.45199260
95axoneme assembly (GO:0035082)2.44161749
96G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.43562512
97kidney morphogenesis (GO:0060993)2.42547766
98aldehyde catabolic process (GO:0046185)2.41570428
99adenosine metabolic process (GO:0046085)2.40706192
100positive regulation of mitochondrial fission (GO:0090141)2.39527678

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.81197983
2VDR_22108803_ChIP-Seq_LS180_Human3.36852024
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.05051614
4HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.74959434
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.62687363
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.57814447
7GBX2_23144817_ChIP-Seq_PC3_Human2.54218580
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.50363253
9IGF1R_20145208_ChIP-Seq_DFB_Human2.48064394
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.33786275
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.33107686
12EWS_26573619_Chip-Seq_HEK293_Human2.32281029
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.29995563
14FUS_26573619_Chip-Seq_HEK293_Human2.28063568
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20325510
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.15820712
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.15188462
18EZH2_22144423_ChIP-Seq_EOC_Human2.14143371
19P300_19829295_ChIP-Seq_ESCs_Human2.10784370
20TAF15_26573619_Chip-Seq_HEK293_Human2.10268919
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.03526469
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01769085
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.94436724
24PCGF2_27294783_Chip-Seq_ESCs_Mouse1.87892775
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86956674
26ELK1_19687146_ChIP-ChIP_HELA_Human1.79477973
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.71310597
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.70910549
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.69161708
30TP53_22573176_ChIP-Seq_HFKS_Human1.64046064
31MYC_18940864_ChIP-ChIP_HL60_Human1.62601684
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59649007
33ER_23166858_ChIP-Seq_MCF-7_Human1.58109526
34MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.57798549
35IRF1_19129219_ChIP-ChIP_H3396_Human1.55581431
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.54346105
37CBP_20019798_ChIP-Seq_JUKART_Human1.52957346
38IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52957346
39VDR_23849224_ChIP-Seq_CD4+_Human1.48849535
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47053428
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43147268
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42790081
43NANOG_19829295_ChIP-Seq_ESCs_Human1.39387015
44SOX2_19829295_ChIP-Seq_ESCs_Human1.39387015
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38340468
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.37378269
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36520215
48BCAT_22108803_ChIP-Seq_LS180_Human1.35162205
49TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34509490
50POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.34509490
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.31952873
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31598434
53SMAD4_21799915_ChIP-Seq_A2780_Human1.31033968
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.30373010
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.30237679
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.30074183
57ETS1_20019798_ChIP-Seq_JURKAT_Human1.29107054
58FOXA1_27270436_Chip-Seq_PROSTATE_Human1.29001473
59FOXA1_25329375_ChIP-Seq_VCAP_Human1.29001473
60JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.28641655
61NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26940065
62AR_25329375_ChIP-Seq_VCAP_Human1.24940205
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.24451140
64KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22512234
65GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21384903
66TCF4_22108803_ChIP-Seq_LS180_Human1.20754975
67STAT3_23295773_ChIP-Seq_U87_Human1.20328425
68NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.19893245
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17207890
70NCOR_22424771_ChIP-Seq_293T_Human1.16439279
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15832765
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15645759
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.14226563
74SRF_21415370_ChIP-Seq_HL-1_Mouse1.14162256
75FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13061654
76CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.12199813
77AR_20517297_ChIP-Seq_VCAP_Human1.11214117
78RNF2_27304074_Chip-Seq_NSC_Mouse1.11005696
79RUNX2_22187159_ChIP-Seq_PCA_Human1.09245363
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09170952
81ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09169680
82TCF4_23295773_ChIP-Seq_U87_Human1.08043597
83FOXP3_21729870_ChIP-Seq_TREG_Human1.07833768
84GATA3_21878914_ChIP-Seq_MCF-7_Human1.06572087
85REST_21632747_ChIP-Seq_MESCs_Mouse1.05508975
86SMAD4_21741376_ChIP-Seq_EPCs_Human1.04941646
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04728892
88PRDM14_20953172_ChIP-Seq_ESCs_Human1.03418014
89EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01509359
90HTT_18923047_ChIP-ChIP_STHdh_Human1.01478443
91KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00971387
92HOXB7_26014856_ChIP-Seq_BT474_Human0.99506512
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99447897
94NANOG_18555785_Chip-Seq_ESCs_Mouse0.99339341
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98465876
96CRX_20693478_ChIP-Seq_RETINA_Mouse0.98134753
97PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97721959
98AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97202409
99P53_22387025_ChIP-Seq_ESCs_Mouse0.95488516
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93706474

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology3.12379560
2MP0008877_abnormal_DNA_methylation2.91653483
3MP0006292_abnormal_olfactory_placode2.84493411
4MP0006072_abnormal_retinal_apoptosis2.73754545
5MP0001968_abnormal_touch/_nociception2.39202877
6MP0003195_calcinosis2.38387654
7MP0003880_abnormal_central_pattern2.34773521
8MP0005551_abnormal_eye_electrophysiolog2.34315395
9MP0000372_irregular_coat_pigmentation2.32807201
10MP0002876_abnormal_thyroid_physiology2.12481390
11MP0005084_abnormal_gallbladder_morpholo2.11341733
12MP0003787_abnormal_imprinting2.00792625
13MP0008875_abnormal_xenobiotic_pharmacok2.00648379
14MP0002938_white_spotting2.00387815
15MP0002837_dystrophic_cardiac_calcinosis1.99788641
16MP0008872_abnormal_physiological_respon1.96663935
17MP0005253_abnormal_eye_physiology1.90137463
18MP0001529_abnormal_vocalization1.88166250
19MP0002736_abnormal_nociception_after1.86527737
20MP0004147_increased_porphyrin_level1.83692438
21MP0003011_delayed_dark_adaptation1.78456428
22MP0001986_abnormal_taste_sensitivity1.72930763
23MP0000569_abnormal_digit_pigmentation1.72669659
24MP0003136_yellow_coat_color1.71152337
25MP0009745_abnormal_behavioral_response1.65194169
26MP0001984_abnormal_olfaction1.55816753
27MP0008789_abnormal_olfactory_epithelium1.55781763
28MP0005645_abnormal_hypothalamus_physiol1.49651463
29MP0004142_abnormal_muscle_tone1.48773598
30MP0002272_abnormal_nervous_system1.48243929
31MP0006276_abnormal_autonomic_nervous1.47383631
32MP0001485_abnormal_pinna_reflex1.46417112
33MP0005646_abnormal_pituitary_gland1.45623694
34MP0004133_heterotaxia1.44613676
35MP0000427_abnormal_hair_cycle1.44435692
36MP0002254_reproductive_system_inflammat1.39658791
37MP0003567_abnormal_fetal_cardiomyocyte1.39431401
38MP0009046_muscle_twitch1.38514669
39MP0005379_endocrine/exocrine_gland_phen1.37293516
40MP0002163_abnormal_gland_morphology1.36333198
41MP0005174_abnormal_tail_pigmentation1.35823920
42MP0008058_abnormal_DNA_repair1.33130508
43MP0002735_abnormal_chemical_nociception1.32589574
44MP0008995_early_reproductive_senescence1.32009035
45MP0001188_hyperpigmentation1.30730633
46MP0001905_abnormal_dopamine_level1.29544998
47MP0000631_abnormal_neuroendocrine_gland1.29209132
48MP0003718_maternal_effect1.25506784
49MP0003786_premature_aging1.23825592
50MP0001501_abnormal_sleep_pattern1.23762400
51MP0004885_abnormal_endolymph1.23216175
52MP0005377_hearing/vestibular/ear_phenot1.22231877
53MP0003878_abnormal_ear_physiology1.22231877
54MP0002638_abnormal_pupillary_reflex1.21257957
55MP0002557_abnormal_social/conspecific_i1.19202550
56MP0002234_abnormal_pharynx_morphology1.17345715
57MP0004043_abnormal_pH_regulation1.16621095
58MP0002572_abnormal_emotion/affect_behav1.16580278
59MP0004742_abnormal_vestibular_system1.14625916
60MP0001486_abnormal_startle_reflex1.13837391
61MP0002067_abnormal_sensory_capabilities1.13009753
62MP0002928_abnormal_bile_duct1.09942682
63MP0003890_abnormal_embryonic-extraembry1.09585506
64MP0003646_muscle_fatigue1.08143484
65MP0002751_abnormal_autonomic_nervous1.08111444
66MP0002733_abnormal_thermal_nociception1.05907816
67MP0005394_taste/olfaction_phenotype1.05742667
68MP0005499_abnormal_olfactory_system1.05742667
69MP0001293_anophthalmia1.02075643
70MP0005389_reproductive_system_phenotype1.00532133
71MP0005195_abnormal_posterior_eye1.00214756
72MP0005085_abnormal_gallbladder_physiolo0.98726599
73MP0004215_abnormal_myocardial_fiber0.98017649
74MP0002277_abnormal_respiratory_mucosa0.96500463
75MP0001919_abnormal_reproductive_system0.95973827
76MP0002095_abnormal_skin_pigmentation0.94556020
77MP0001970_abnormal_pain_threshold0.94147463
78MP0001873_stomach_inflammation0.92035720
79MP0001502_abnormal_circadian_rhythm0.90795811
80MP0004924_abnormal_behavior0.90647177
81MP0005386_behavior/neurological_phenoty0.90647177
82MP0000516_abnormal_urinary_system0.90158741
83MP0005367_renal/urinary_system_phenotyp0.90158741
84MP0002734_abnormal_mechanical_nocicepti0.90153732
85MP0002752_abnormal_somatic_nervous0.90080828
86MP0002653_abnormal_ependyma_morphology0.90065655
87MP0002160_abnormal_reproductive_system0.89298978
88MP0000778_abnormal_nervous_system0.87176569
89MP0010386_abnormal_urinary_bladder0.87014142
90MP0004145_abnormal_muscle_electrophysio0.85456610
91MP0005083_abnormal_biliary_tract0.84475574
92MP0000647_abnormal_sebaceous_gland0.81677488
93MP0003252_abnormal_bile_duct0.81472050
94MP0003635_abnormal_synaptic_transmissio0.80830940
95MP0003122_maternal_imprinting0.80003595
96MP0005391_vision/eye_phenotype0.79404064
97MP0002064_seizures0.79208880
98MP0003137_abnormal_impulse_conducting0.78827037
99MP0003121_genomic_imprinting0.78583120
100MP0001324_abnormal_eye_pigmentation0.78089458

Predicted human phenotypes

RankGene SetZ-score
1Molar tooth sign on MRI (HP:0002419)4.72788723
2Abnormality of midbrain morphology (HP:0002418)4.72788723
3Pancreatic cysts (HP:0001737)4.51478765
4Pancreatic fibrosis (HP:0100732)4.26640490
5True hermaphroditism (HP:0010459)3.88008352
6Nephronophthisis (HP:0000090)3.77944620
7Congenital stationary night blindness (HP:0007642)3.40055115
8Abnormality of the renal medulla (HP:0100957)3.28039448
9Colon cancer (HP:0003003)3.02365273
10Acute necrotizing encephalopathy (HP:0006965)2.93921681
11Mitochondrial inheritance (HP:0001427)2.93021659
12Abnormality of the renal cortex (HP:0011035)2.91008670
13Abolished electroretinogram (ERG) (HP:0000550)2.87582671
14Increased CSF lactate (HP:0002490)2.73198500
15Type II lissencephaly (HP:0007260)2.70127479
16Acute encephalopathy (HP:0006846)2.68221282
17Cystic liver disease (HP:0006706)2.66577382
18Sclerocornea (HP:0000647)2.65600439
19Tubular atrophy (HP:0000092)2.63109323
20Congenital, generalized hypertrichosis (HP:0004540)2.60617620
21Pendular nystagmus (HP:0012043)2.57858150
22Abnormal mitochondria in muscle tissue (HP:0008316)2.54410880
23Progressive macrocephaly (HP:0004481)2.54262431
24Anencephaly (HP:0002323)2.52944901
25Chronic hepatic failure (HP:0100626)2.51329139
26Methylmalonic acidemia (HP:0002912)2.50518115
27Thyroid-stimulating hormone excess (HP:0002925)2.50090949
28Increased hepatocellular lipid droplets (HP:0006565)2.50067290
29Attenuation of retinal blood vessels (HP:0007843)2.47079503
30Abnormal rod and cone electroretinograms (HP:0008323)2.45005123
31Hepatocellular necrosis (HP:0001404)2.41901397
32Abnormal biliary tract physiology (HP:0012439)2.38596197
33Bile duct proliferation (HP:0001408)2.38596197
34Medial flaring of the eyebrow (HP:0010747)2.37436629
35Aplasia/Hypoplasia of the tongue (HP:0010295)2.37123789
36Lipid accumulation in hepatocytes (HP:0006561)2.36130959
37Absent rod-and cone-mediated responses on ERG (HP:0007688)2.35538887
383-Methylglutaconic aciduria (HP:0003535)2.31378474
39Optic disc pallor (HP:0000543)2.28789795
40Progressive inability to walk (HP:0002505)2.26395907
41Inability to walk (HP:0002540)2.25284254
42Methylmalonic aciduria (HP:0012120)2.23875080
43Keratoconus (HP:0000563)2.23157984
44Increased corneal curvature (HP:0100692)2.23157984
45Hepatic necrosis (HP:0002605)2.21416797
46Large for gestational age (HP:0001520)2.19825174
47Intestinal atresia (HP:0011100)2.18976751
48Renal cortical cysts (HP:0000803)2.18763360
49Abnormal drinking behavior (HP:0030082)2.15715359
50Polydipsia (HP:0001959)2.15715359
51Lissencephaly (HP:0001339)2.12918226
52Concave nail (HP:0001598)2.06476387
53Hyperventilation (HP:0002883)2.05281813
54Congenital hepatic fibrosis (HP:0002612)2.01770632
55Retinal dysplasia (HP:0007973)2.00364403
56Male pseudohermaphroditism (HP:0000037)1.97220948
57Abnormality of the labia minora (HP:0012880)1.96545588
58Decreased central vision (HP:0007663)1.96500472
59Aplasia/hypoplasia of the uterus (HP:0008684)1.95676604
60Increased serum lactate (HP:0002151)1.94841734
61Abnormality of the ileum (HP:0001549)1.94717274
62Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94314212
63Furrowed tongue (HP:0000221)1.94171383
64Postaxial foot polydactyly (HP:0001830)1.91132838
65Renal Fanconi syndrome (HP:0001994)1.90427226
66Optic nerve hypoplasia (HP:0000609)1.90352994
67Gait imbalance (HP:0002141)1.87427735
68Hypoplasia of the pons (HP:0012110)1.87324853
69Hypothermia (HP:0002045)1.86774588
70Aplasia/Hypoplasia of the tibia (HP:0005772)1.85991944
71Limb dystonia (HP:0002451)1.84916230
72Abnormality of the pons (HP:0007361)1.84497063
73Mesangial abnormality (HP:0001966)1.83610697
74Abnormality of macular pigmentation (HP:0008002)1.83540136
75Gaze-evoked nystagmus (HP:0000640)1.82932765
76Stomatitis (HP:0010280)1.82198212
77Cerebellar dysplasia (HP:0007033)1.82175045
78Polyuria (HP:0000103)1.81399526
79Meckel diverticulum (HP:0002245)1.81063675
80Delayed CNS myelination (HP:0002188)1.80762236
81Broad-based gait (HP:0002136)1.79996553
82Abnormal number of erythroid precursors (HP:0012131)1.79881798
83Dandy-Walker malformation (HP:0001305)1.79805541
84Congenital primary aphakia (HP:0007707)1.79020502
85Aplastic anemia (HP:0001915)1.78136122
86Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77433613
87Abnormality of alanine metabolism (HP:0010916)1.77433613
88Hyperalaninemia (HP:0003348)1.77433613
89Patellar aplasia (HP:0006443)1.76910297
90Oculomotor apraxia (HP:0000657)1.75517418
91Narrow forehead (HP:0000341)1.74790655
92Abnormal respiratory epithelium morphology (HP:0012253)1.73539921
93Abnormal respiratory motile cilium morphology (HP:0005938)1.73539921
94Decreased electroretinogram (ERG) amplitude (HP:0000654)1.73481072
95Type 2 muscle fiber atrophy (HP:0003554)1.72950707
96Constricted visual fields (HP:0001133)1.72387954
97Aplasia/Hypoplasia of the uvula (HP:0010293)1.72199598
98Hypoalbuminemia (HP:0003073)1.70411499
99Abnormal albumin level (HP:0012116)1.70411499
100Aplasia/Hypoplasia of the patella (HP:0006498)1.69863829

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.84565019
2ADRBK23.27571305
3MAP4K22.99091978
4ZAK2.93723748
5NUAK12.90610724
6WNK32.80967038
7GRK12.59611595
8BMPR1B2.49956300
9TXK2.14585825
10PINK12.09071839
11TNIK2.05103982
12MST42.01075697
13CASK2.00917081
14VRK21.94794104
15INSRR1.85453530
16ACVR1B1.83792685
17TLK11.71374205
18TAOK31.68414708
19MAPK131.53237844
20NME11.47412897
21MARK11.46464403
22OXSR11.44188821
23WNK41.43548498
24BCKDK1.33923741
25VRK11.33433604
26DYRK21.31233970
27MUSK1.30042807
28MAP3K41.26277569
29BCR1.21512842
30BUB11.21119089
31TRIM281.17459985
32MKNK21.17113780
33SRPK11.12735634
34STK391.12167519
35PBK1.08574742
36EIF2AK31.08021213
37PAK31.07779701
38BRSK21.06849097
39PLK31.05162032
40TSSK61.02436157
41STK38L1.02297823
42PRKCE0.99006010
43PRKCG0.97138319
44STK160.97011032
45TIE10.96941716
46MAP2K70.92500661
47TAF10.92457764
48PNCK0.92218130
49EPHA40.91636242
50PLK20.91540688
51ADRBK10.85236390
52AKT30.84918116
53MAP2K60.83463820
54WEE10.80756761
55CSNK1G10.76874133
56TGFBR10.75610568
57CSNK1G20.72915739
58MKNK10.71768003
59PLK40.70705461
60PHKG10.65592793
61PHKG20.65592793
62CSNK1G30.64822680
63PRKCI0.62216921
64PRKCQ0.61812157
65DAPK20.61093497
66RPS6KA50.57092941
67CAMK2A0.56539242
68MAP3K120.56288163
69CSNK1A1L0.55150859
70CDK190.54880900
71DYRK30.54560630
72NLK0.51685866
73CCNB10.51571351
74NTRK20.51359716
75PLK10.49997168
76PIK3CA0.48691258
77FGFR20.45989252
78IKBKB0.45985270
79PRKACA0.45010594
80CHEK20.44851501
81KIT0.44486736
82STK30.43626302
83NEK10.41885153
84EIF2AK20.41040350
85ERBB30.38753041
86PTK2B0.38027081
87RPS6KA40.37632290
88CSNK1A10.36282138
89PKN10.35382002
90CAMKK20.35317089
91STK110.35049372
92MAPK150.33995365
93CAMK2D0.33913900
94MATK0.33496991
95TEC0.32309354
96PRKCA0.31766149
97TTK0.31550670
98CDC70.31343551
99MINK10.30562672
100GRK70.30289133

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.07666314
2Protein export_Homo sapiens_hsa030602.75525335
3Proteasome_Homo sapiens_hsa030502.63524892
4Parkinsons disease_Homo sapiens_hsa050122.52743679
5RNA polymerase_Homo sapiens_hsa030202.46698855
6Phototransduction_Homo sapiens_hsa047442.32506135
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.26653369
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.20232426
9Butanoate metabolism_Homo sapiens_hsa006502.03466494
10Homologous recombination_Homo sapiens_hsa034401.93882501
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.93353653
12Basal transcription factors_Homo sapiens_hsa030221.91227310
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.90279617
14Linoleic acid metabolism_Homo sapiens_hsa005911.87081343
15Nitrogen metabolism_Homo sapiens_hsa009101.83103233
16Huntingtons disease_Homo sapiens_hsa050161.71529524
17Tryptophan metabolism_Homo sapiens_hsa003801.70708734
18Fanconi anemia pathway_Homo sapiens_hsa034601.69607046
19Selenocompound metabolism_Homo sapiens_hsa004501.67106666
20Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.65621001
21One carbon pool by folate_Homo sapiens_hsa006701.65552898
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.63246981
23RNA degradation_Homo sapiens_hsa030181.60687242
24Alzheimers disease_Homo sapiens_hsa050101.58662790
25Propanoate metabolism_Homo sapiens_hsa006401.57169746
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.55356985
27Nicotine addiction_Homo sapiens_hsa050331.53281996
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.49765586
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.48704935
30Caffeine metabolism_Homo sapiens_hsa002321.46912059
31Cardiac muscle contraction_Homo sapiens_hsa042601.44230801
32Ribosome_Homo sapiens_hsa030101.40206893
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39765672
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37571300
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25941270
36Ether lipid metabolism_Homo sapiens_hsa005651.22837689
37Asthma_Homo sapiens_hsa053101.18617181
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.15622011
39Fatty acid elongation_Homo sapiens_hsa000621.14147805
40Mismatch repair_Homo sapiens_hsa034301.12291841
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.10573330
42Non-homologous end-joining_Homo sapiens_hsa034501.07141569
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05767156
44Autoimmune thyroid disease_Homo sapiens_hsa053201.01328406
45Steroid biosynthesis_Homo sapiens_hsa001001.00160262
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99662860
47Olfactory transduction_Homo sapiens_hsa047400.99478762
48Primary immunodeficiency_Homo sapiens_hsa053400.99334468
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98463144
50Peroxisome_Homo sapiens_hsa041460.97684401
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.96201397
52Purine metabolism_Homo sapiens_hsa002300.95477860
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.91196163
54Retinol metabolism_Homo sapiens_hsa008300.89025780
55Allograft rejection_Homo sapiens_hsa053300.89005885
56Chemical carcinogenesis_Homo sapiens_hsa052040.86917430
57Pyrimidine metabolism_Homo sapiens_hsa002400.86756851
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85756101
59Taste transduction_Homo sapiens_hsa047420.82213231
60Morphine addiction_Homo sapiens_hsa050320.79730249
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77422113
62Nucleotide excision repair_Homo sapiens_hsa034200.76086057
63Metabolic pathways_Homo sapiens_hsa011000.75519616
64beta-Alanine metabolism_Homo sapiens_hsa004100.72821120
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.72815716
66Arachidonic acid metabolism_Homo sapiens_hsa005900.70657991
67Spliceosome_Homo sapiens_hsa030400.70080911
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.69769939
69Type I diabetes mellitus_Homo sapiens_hsa049400.69378969
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.68486439
71RNA transport_Homo sapiens_hsa030130.68121852
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67443686
73Serotonergic synapse_Homo sapiens_hsa047260.65142231
74Collecting duct acid secretion_Homo sapiens_hsa049660.64865983
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62475975
76GABAergic synapse_Homo sapiens_hsa047270.61581952
77Fatty acid degradation_Homo sapiens_hsa000710.58294486
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57295305
79Insulin secretion_Homo sapiens_hsa049110.56317109
80Folate biosynthesis_Homo sapiens_hsa007900.56312470
81Fatty acid metabolism_Homo sapiens_hsa012120.56022447
82Base excision repair_Homo sapiens_hsa034100.54574376
83Sulfur metabolism_Homo sapiens_hsa009200.54291791
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50156706
85Graft-versus-host disease_Homo sapiens_hsa053320.49958014
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49909655
87ABC transporters_Homo sapiens_hsa020100.49863535
88Regulation of autophagy_Homo sapiens_hsa041400.48900736
89Circadian rhythm_Homo sapiens_hsa047100.48060376
90Glutamatergic synapse_Homo sapiens_hsa047240.46907031
91Fat digestion and absorption_Homo sapiens_hsa049750.45573390
92Glycerolipid metabolism_Homo sapiens_hsa005610.45004357
93Vitamin B6 metabolism_Homo sapiens_hsa007500.43304870
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40527333
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.40106210
96Ovarian steroidogenesis_Homo sapiens_hsa049130.39880263
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39200981
98Vitamin digestion and absorption_Homo sapiens_hsa049770.38705974
99Hedgehog signaling pathway_Homo sapiens_hsa043400.38234065
100Mineral absorption_Homo sapiens_hsa049780.37569991

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