ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synapsis (GO:0007129)	4.44457950
2	pyrimidine nucleobase catabolic process (GO:0006208)	4.24253309
3	DNA double-strand break processing (GO:0000729)	4.14429569
4	axonal fasciculation (GO:0007413)	4.08301486
5	somite development (GO:0061053)	4.01554770
6	limb bud formation (GO:0060174)	3.86592517
7	retinal cone cell development (GO:0046549)	3.86069946
8	negative regulation of axon guidance (GO:1902668)	3.72256633
9	lateral sprouting from an epithelium (GO:0060601)	3.69670784
10	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.62161538
11	presynaptic membrane assembly (GO:0097105)	3.61077572
12	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.57759102
13	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.57759102
14	reciprocal DNA recombination (GO:0035825)	3.55684200
15	reciprocal meiotic recombination (GO:0007131)	3.55684200
16	meiotic chromosome segregation (GO:0045132)	3.49654589
17	behavioral response to nicotine (GO:0035095)	3.43306893
18	regulation of timing of cell differentiation (GO:0048505)	3.41641739
19	spermatid nucleus differentiation (GO:0007289)	3.38674640
20	protein complex biogenesis (GO:0070271)	3.36322670
21	negative regulation of axon extension involved in axon guidance (GO:0048843)	3.35654942
22	respiratory chain complex IV assembly (GO:0008535)	3.35531896
23	mitochondrial respiratory chain complex assembly (GO:0033108)	3.34646204
24	negative regulation of DNA recombination (GO:0045910)	3.31594015
25	nucleobase catabolic process (GO:0046113)	3.28538132
26	otic vesicle formation (GO:0030916)	3.26394444
27	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.25889022
28	NADH dehydrogenase complex assembly (GO:0010257)	3.25889022
29	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.25889022
30	resolution of meiotic recombination intermediates (GO:0000712)	3.25254189
31	neuron fate determination (GO:0048664)	3.23988800
32	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.16305841
33	replication fork processing (GO:0031297)	3.16200697
34	presynaptic membrane organization (GO:0097090)	3.13462071
35	water-soluble vitamin biosynthetic process (GO:0042364)	3.09931940
36	chromosome organization involved in meiosis (GO:0070192)	3.09186345
37	centriole replication (GO:0007099)	3.00333534
38	neuron recognition (GO:0008038)	3.00322933
39	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	3.00232183
40	negative regulation of organelle assembly (GO:1902116)	2.97761949
41	positive regulation of dendritic spine morphogenesis (GO:0061003)	2.96007518
42	regulation of development, heterochronic (GO:0040034)	2.94483273
43	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	2.92360491
44	DNA replication-dependent nucleosome assembly (GO:0006335)	2.92092477
45	DNA replication-dependent nucleosome organization (GO:0034723)	2.92092477
46	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.90829102
47	male meiosis I (GO:0007141)	2.87537015
48	protein polyglutamylation (GO:0018095)	2.86889169
49	cerebral cortex radially oriented cell migration (GO:0021799)	2.85485716
50	negative regulation of glial cell differentiation (GO:0045686)	2.84222838
51	recombinational repair (GO:0000725)	2.79788743
52	double-strand break repair via homologous recombination (GO:0000724)	2.79113935
53	piRNA metabolic process (GO:0034587)	2.77064404
54	response to pheromone (GO:0019236)	2.74013463
55	nonmotile primary cilium assembly (GO:0035058)	2.72322925
56	postsynaptic membrane organization (GO:0001941)	2.71673651
57	neuronal stem cell maintenance (GO:0097150)	2.70994484
58	meiosis I (GO:0007127)	2.70198677
59	retinal rod cell development (GO:0046548)	2.70181463
60	lysine catabolic process (GO:0006554)	2.69055538
61	lysine metabolic process (GO:0006553)	2.69055538
62	negative regulation of astrocyte differentiation (GO:0048712)	2.68984424
63	cytochrome complex assembly (GO:0017004)	2.68389414
64	intraciliary transport (GO:0042073)	2.68272992
65	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.67059729
66	primitive streak formation (GO:0090009)	2.66207574
67	regulation of centriole replication (GO:0046599)	2.66186013
68	retinal ganglion cell axon guidance (GO:0031290)	2.62639446
69	male meiosis (GO:0007140)	2.61280411
70	protein K6-linked ubiquitination (GO:0085020)	2.60744495
71	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	2.58770023
72	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.55696621
73	photoreceptor cell development (GO:0042461)	2.55669990
74	eye photoreceptor cell development (GO:0042462)	2.54910830
75	neuron cell-cell adhesion (GO:0007158)	2.54605934
76	regulation of telomere maintenance (GO:0032204)	2.52193534
77	chromatin remodeling at centromere (GO:0031055)	2.51605450
78	dopaminergic neuron differentiation (GO:0071542)	2.51181271
79	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.50802720
80	regulation of hippo signaling (GO:0035330)	2.50339378
81	DNA deamination (GO:0045006)	2.48267844
82	regulation of axon guidance (GO:1902667)	2.47572306
83	negative regulation of oligodendrocyte differentiation (GO:0048715)	2.47326317
84	regulation of hexokinase activity (GO:1903299)	2.46658608
85	regulation of glucokinase activity (GO:0033131)	2.46658608
86	nephron epithelium morphogenesis (GO:0072088)	2.46582870
87	nephron tubule morphogenesis (GO:0072078)	2.46582870
88	regulation of astrocyte differentiation (GO:0048710)	2.45663592
89	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.44835442
90	negative regulation of axon extension (GO:0030517)	2.44113123
91	kinetochore assembly (GO:0051382)	2.43624357
92	establishment of tissue polarity (GO:0007164)	2.41880104
93	establishment of planar polarity (GO:0001736)	2.41880104
94	olfactory bulb development (GO:0021772)	2.41842046
95	intracellular protein transmembrane import (GO:0044743)	2.36502835
96	somatic diversification of immunoglobulins (GO:0016445)	2.35374652
97	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.33409760
98	isotype switching (GO:0045190)	2.33409760
99	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.33409760
100	synaptic transmission, cholinergic (GO:0007271)	2.32736121

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	4.18783984
2	TAF15_26573619_Chip-Seq_HEK293_Human	3.12114729
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.07876508
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.07264932
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.96631171
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.89041834
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.78845056
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.59084688
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.55606280
10	EWS_26573619_Chip-Seq_HEK293_Human	2.43940850
11	FUS_26573619_Chip-Seq_HEK293_Human	2.43165939
12	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.39056274
13	POU5F1_16153702_ChIP-ChIP_HESCs_Human	2.36530208
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.36439988
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.31438813
16	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.24208502
17	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.16895703
18	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.14276660
19	P300_19829295_ChIP-Seq_ESCs_Human	2.11244023
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.09984564
21	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.08274031
22	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.02118067
23	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.88184687
24	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.87511367
25	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.81871129
26	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.81173917
27	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.75845984
28	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.74755787
29	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.74641598
30	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.69266207
31	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.68364034
32	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.68328105
33	BCAT_22108803_ChIP-Seq_LS180_Human	1.67864999
34	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.66736523
35	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.63874562
36	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.59411636
37	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.57296661
38	MYC_18940864_ChIP-ChIP_HL60_Human	1.56223119
39	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.53854789
40	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.53366119
41	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.51652763
42	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.48411233
43	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.46133756
44	ELK1_19687146_ChIP-ChIP_HELA_Human	1.46036279
45	VDR_22108803_ChIP-Seq_LS180_Human	1.45955312
46	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.45079189
47	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.44851139
48	RNF2_27304074_Chip-Seq_NSC_Mouse	1.43285926
49	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.43140357
50	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.40890918
51	ER_23166858_ChIP-Seq_MCF-7_Human	1.38754742
52	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.38462848
53	IRF1_19129219_ChIP-ChIP_H3396_Human	1.32629088
54	SMAD4_21799915_ChIP-Seq_A2780_Human	1.31795018
55	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.31367610
56	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.30182657
57	SOX9_26525672_Chip-Seq_HEART_Mouse	1.29931660
58	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.28643542
59	AR_25329375_ChIP-Seq_VCAP_Human	1.27638821
60	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.26694194
61	STAT3_23295773_ChIP-Seq_U87_Human	1.26552887
62	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.24064164
63	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.23945351
64	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.19500300
65	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.18680031
66	CBP_20019798_ChIP-Seq_JUKART_Human	1.18680031
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17260661
68	REST_21632747_ChIP-Seq_MESCs_Mouse	1.15715371
69	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.15461325
70	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.14692073
71	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.10109774
72	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10109774
73	RUNX2_22187159_ChIP-Seq_PCA_Human	1.09942077
74	TP53_16413492_ChIP-PET_HCT116_Human	1.07208111
75	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.06434023
76	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.06157911
77	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.06081693
78	SOX2_19829295_ChIP-Seq_ESCs_Human	1.05381571
79	NANOG_19829295_ChIP-Seq_ESCs_Human	1.05381571
80	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.05101835
81	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.04356752
82	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.04324219
83	TP53_22573176_ChIP-Seq_HFKS_Human	1.04073601
84	AR_21572438_ChIP-Seq_LNCaP_Human	1.03727172
85	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.03026627
86	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.02522194
87	P53_22387025_ChIP-Seq_ESCs_Mouse	1.02444274
88	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.02370181
89	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.02254436
90	IGF1R_20145208_ChIP-Seq_DFB_Human	1.02244648
91	TCF4_23295773_ChIP-Seq_U87_Human	1.01977290
92	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.01462866
93	E2F7_22180533_ChIP-Seq_HELA_Human	1.01448063
94	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00522159
95	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.00411779
96	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.99110648
97	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.99107476
98	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.96028255
99	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.95149978
100	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	0.94252724

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002653_abnormal_ependyma_morphology	3.49642358
2	MP0003136_yellow_coat_color	3.36985132
3	MP0008877_abnormal_DNA_methylation	3.11105006
4	MP0008789_abnormal_olfactory_epithelium	2.46839219
5	MP0003880_abnormal_central_pattern	2.43951149
6	MP0000778_abnormal_nervous_system	2.38448326
7	MP0001529_abnormal_vocalization	2.31282512
8	MP0003121_genomic_imprinting	2.29094033
9	MP0003787_abnormal_imprinting	2.18408738
10	MP0005394_taste/olfaction_phenotype	2.17604183
11	MP0005499_abnormal_olfactory_system	2.17604183
12	MP0005551_abnormal_eye_electrophysiolog	2.17306042
13	MP0008058_abnormal_DNA_repair	2.14511779
14	MP0003122_maternal_imprinting	2.08159841
15	MP0002282_abnormal_trachea_morphology	2.01919123
16	MP0000566_synostosis	2.00486871
17	MP0009053_abnormal_anal_canal	1.98910702
18	MP0006292_abnormal_olfactory_placode	1.94919218
19	MP0002277_abnormal_respiratory_mucosa	1.93548241
20	MP0000427_abnormal_hair_cycle	1.90908411
21	MP0001485_abnormal_pinna_reflex	1.85916475
22	MP0000631_abnormal_neuroendocrine_gland	1.82914868
23	MP0004133_heterotaxia	1.82912812
24	MP0000569_abnormal_digit_pigmentation	1.77146714
25	MP0003011_delayed_dark_adaptation	1.70562201
26	MP0003890_abnormal_embryonic-extraembry	1.69301838
27	MP0003937_abnormal_limbs/digits/tail_de	1.62194663
28	MP0008995_early_reproductive_senescence	1.61226738
29	MP0009379_abnormal_foot_pigmentation	1.57647232
30	MP0002233_abnormal_nose_morphology	1.52510042
31	MP0008872_abnormal_physiological_respon	1.51955959
32	MP0001984_abnormal_olfaction	1.49432447
33	MP0002102_abnormal_ear_morphology	1.46719080
34	MP0010094_abnormal_chromosome_stability	1.44534267
35	MP0002938_white_spotting	1.43371915
36	MP0003119_abnormal_digestive_system	1.39758918
37	MP0004142_abnormal_muscle_tone	1.39190455
38	MP0002751_abnormal_autonomic_nervous	1.37486705
39	MP0000049_abnormal_middle_ear	1.37419418
40	MP0005253_abnormal_eye_physiology	1.32845658
41	MP0000647_abnormal_sebaceous_gland	1.31929982
42	MP0002736_abnormal_nociception_after	1.30315602
43	MP0003283_abnormal_digestive_organ	1.30106766
44	MP0005174_abnormal_tail_pigmentation	1.27681195
45	MP0001293_anophthalmia	1.27338573
46	MP0000955_abnormal_spinal_cord	1.24063108
47	MP0005195_abnormal_posterior_eye	1.23879862
48	MP0005646_abnormal_pituitary_gland	1.23751462
49	MP0000383_abnormal_hair_follicle	1.23051915
50	MP0005377_hearing/vestibular/ear_phenot	1.20348370
51	MP0003878_abnormal_ear_physiology	1.20348370
52	MP0009745_abnormal_behavioral_response	1.19291642
53	MP0002557_abnormal_social/conspecific_i	1.18174152
54	MP0000537_abnormal_urethra_morphology	1.17443505
55	MP0002160_abnormal_reproductive_system	1.16096660
56	MP0001929_abnormal_gametogenesis	1.14378394
57	MP0002095_abnormal_skin_pigmentation	1.14193109
58	MP0003786_premature_aging	1.12810156
59	MP0006072_abnormal_retinal_apoptosis	1.10737631
60	MP0001486_abnormal_startle_reflex	1.07309652
61	MP0003755_abnormal_palate_morphology	1.06731581
62	MP0003195_calcinosis	1.04681362
63	MP0002234_abnormal_pharynx_morphology	1.04289715
64	MP0002572_abnormal_emotion/affect_behav	1.04170521
65	MP0000534_abnormal_ureter_morphology	1.03885747
66	MP0004270_analgesia	1.03498552
67	MP0001188_hyperpigmentation	1.02249703
68	MP0002210_abnormal_sex_determination	1.01895226
69	MP0002752_abnormal_somatic_nervous	1.01836315
70	MP0002067_abnormal_sensory_capabilities	0.99901497
71	MP0008875_abnormal_xenobiotic_pharmacok	0.99694347
72	MP0001286_abnormal_eye_development	0.99666147
73	MP0002184_abnormal_innervation	0.98879491
74	MP0003698_abnormal_male_reproductive	0.98237996
75	MP0002272_abnormal_nervous_system	0.98174328
76	MP0002735_abnormal_chemical_nociception	0.96497411
77	MP0004043_abnormal_pH_regulation	0.95895417
78	MP0000467_abnormal_esophagus_morphology	0.95042463
79	MP0003635_abnormal_synaptic_transmissio	0.92311575
80	MP0002932_abnormal_joint_morphology	0.91763316
81	MP0004742_abnormal_vestibular_system	0.90688355
82	MP0002111_abnormal_tail_morphology	0.89642577
83	MP0003938_abnormal_ear_development	0.89531007
84	MP0002882_abnormal_neuron_morphology	0.88234816
85	MP0005389_reproductive_system_phenotype	0.86926373
86	MP0005367_renal/urinary_system_phenotyp	0.86749337
87	MP0000516_abnormal_urinary_system	0.86749337
88	MP0002734_abnormal_mechanical_nocicepti	0.86710034
89	MP0004924_abnormal_behavior	0.86095527
90	MP0005386_behavior/neurological_phenoty	0.86095527
91	MP0002063_abnormal_learning/memory/cond	0.85967871
92	MP0003942_abnormal_urinary_system	0.85449465
93	MP0000653_abnormal_sex_gland	0.85329267
94	MP0001145_abnormal_male_reproductive	0.84780120
95	MP0000026_abnormal_inner_ear	0.84777657
96	MP0002152_abnormal_brain_morphology	0.84622499
97	MP0005391_vision/eye_phenotype	0.84546210
98	MP0006276_abnormal_autonomic_nervous	0.82055012
99	MP0003861_abnormal_nervous_system	0.81731741
100	MP0001968_abnormal_touch/_nociception	0.80805601

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the labia minora (HP:0012880)	3.60921288
2	Colon cancer (HP:0003003)	3.59441017
3	Abnormality of alanine metabolism (HP:0010916)	3.48610015
4	Hyperalaninemia (HP:0003348)	3.48610015
5	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.48610015
6	Progressive cerebellar ataxia (HP:0002073)	3.43004443
7	Medial flaring of the eyebrow (HP:0010747)	3.10418269
8	True hermaphroditism (HP:0010459)	3.08483245
9	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.05888761
10	Chronic hepatic failure (HP:0100626)	2.93581754
11	Nephronophthisis (HP:0000090)	2.91726677
12	Pancreatic cysts (HP:0001737)	2.90965577
13	Molar tooth sign on MRI (HP:0002419)	2.82946886
14	Abnormality of midbrain morphology (HP:0002418)	2.82946886
15	Shawl scrotum (HP:0000049)	2.72408276
16	Pancreatic fibrosis (HP:0100732)	2.72147352
17	Glioma (HP:0009733)	2.56559228
18	Gait imbalance (HP:0002141)	2.53114109
19	Midline defect of the nose (HP:0004122)	2.50145597
20	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.48000366
21	Congenital primary aphakia (HP:0007707)	2.47332155
22	Large for gestational age (HP:0001520)	2.45323989
23	Pendular nystagmus (HP:0012043)	2.43640245
24	Vaginal atresia (HP:0000148)	2.39629125
25	Nephrogenic diabetes insipidus (HP:0009806)	2.37645856
26	Septo-optic dysplasia (HP:0100842)	2.37438645
27	Genital tract atresia (HP:0001827)	2.34949556
28	Chorioretinal atrophy (HP:0000533)	2.27116256
29	Sclerocornea (HP:0000647)	2.24152534
30	Chromsome breakage (HP:0040012)	2.23124097
31	Reticulocytopenia (HP:0001896)	2.22887666
32	Volvulus (HP:0002580)	2.22498166
33	Abnormality of the renal medulla (HP:0100957)	2.19539749
34	Renal cortical cysts (HP:0000803)	2.18600510
35	Meckel diverticulum (HP:0002245)	2.14638163
36	Esophageal atresia (HP:0002032)	2.14098742
37	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.13263704
38	Absent/shortened dynein arms (HP:0200106)	2.13263704
39	Supernumerary spleens (HP:0009799)	2.11749962
40	Abnormality of chromosome stability (HP:0003220)	2.11573001
41	Birth length less than 3rd percentile (HP:0003561)	2.10786988
42	Preaxial foot polydactyly (HP:0001841)	2.09046876
43	Abnormality of the astrocytes (HP:0100707)	2.08586661
44	Astrocytoma (HP:0009592)	2.08586661
45	Abnormality of serum amino acid levels (HP:0003112)	2.04164568
46	Abnormality of the renal cortex (HP:0011035)	2.04094677
47	Abnormality of the ileum (HP:0001549)	2.03093242
48	Large earlobe (HP:0009748)	2.01432045
49	Optic nerve hypoplasia (HP:0000609)	2.00073950
50	Gaze-evoked nystagmus (HP:0000640)	1.98811700
51	Abnormality of macular pigmentation (HP:0008002)	1.96203275
52	Abnormality of the middle phalanges of the toes (HP:0010183)	1.94779681
53	Anencephaly (HP:0002323)	1.94534905
54	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.94347274
55	Optic disc pallor (HP:0000543)	1.94202017
56	Bilateral microphthalmos (HP:0007633)	1.92829767
57	Absent speech (HP:0001344)	1.91742974
58	Ependymoma (HP:0002888)	1.91526681
59	Small hand (HP:0200055)	1.91225193
60	Anophthalmia (HP:0000528)	1.91089491
61	Broad foot (HP:0001769)	1.89597488
62	Lissencephaly (HP:0001339)	1.89507188
63	Gastrointestinal atresia (HP:0002589)	1.89292584
64	Broad-based gait (HP:0002136)	1.89032762
65	3-Methylglutaconic aciduria (HP:0003535)	1.86964099
66	Sloping forehead (HP:0000340)	1.85863345
67	Bifid tongue (HP:0010297)	1.85006564
68	Increased serum lactate (HP:0002151)	1.84850888
69	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.84309185
70	Absent septum pellucidum (HP:0001331)	1.81597621
71	Postaxial hand polydactyly (HP:0001162)	1.80220440
72	Acute necrotizing encephalopathy (HP:0006965)	1.79120562
73	Impulsivity (HP:0100710)	1.78052551
74	Short hallux (HP:0010109)	1.77739102
75	Preaxial hand polydactyly (HP:0001177)	1.76777683
76	Short foot (HP:0001773)	1.75901870
77	Triphalangeal thumb (HP:0001199)	1.71920651
78	Postaxial foot polydactyly (HP:0001830)	1.71681174
79	Stomach cancer (HP:0012126)	1.71604429
80	Genetic anticipation (HP:0003743)	1.70709265
81	Posterior subcapsular cataract (HP:0007787)	1.70413362
82	Hyperglycinemia (HP:0002154)	1.70220615
83	Abnormality of serine family amino acid metabolism (HP:0010894)	1.69799764
84	Abnormality of glycine metabolism (HP:0010895)	1.69799764
85	Abolished electroretinogram (ERG) (HP:0000550)	1.69400676
86	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.68936857
87	Widely spaced teeth (HP:0000687)	1.68631056
88	High anterior hairline (HP:0009890)	1.67836788
89	Neoplasm of the oral cavity (HP:0100649)	1.67800759
90	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.66340874
91	Hepatocellular necrosis (HP:0001404)	1.66131366
92	Increased corneal curvature (HP:0100692)	1.65672620
93	Keratoconus (HP:0000563)	1.65672620
94	Cystic liver disease (HP:0006706)	1.65112638
95	Scrotal hypoplasia (HP:0000046)	1.64304655
96	Congenital stationary night blindness (HP:0007642)	1.63671349
97	Ectopic kidney (HP:0000086)	1.62970441
98	Congenital hepatic fibrosis (HP:0002612)	1.62352905
99	Hemiparesis (HP:0001269)	1.62288594
100	Abnormal lung lobation (HP:0002101)	1.62184366

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	4.43516536
2	PNCK	3.54090995
3	WNK3	3.44298197
4	EPHA4	3.30069442
5	BMPR1B	2.96366776
6	PBK	2.60862655
7	ZAK	2.60806907
8	PINK1	2.48900833
9	MAP3K4	2.38737668
10	TNIK	2.21894356
11	NUAK1	2.15376519
12	EPHB2	2.08778232
13	PLK4	2.07775256
14	BCR	2.06258202
15	WEE1	1.86805891
16	MUSK	1.84697446
17	CASK	1.76661467
18	NME1	1.69069855
19	MKNK2	1.60256039
20	FRK	1.59945077
21	TTK	1.53829237
22	MARK1	1.45779142
23	KSR1	1.33409719
24	NTRK2	1.25262507
25	BCKDK	1.22875218
26	CSNK1G1	1.21857028
27	ADRBK2	1.17391853
28	CDC7	1.15981990
29	VRK1	1.14637267
30	CCNB1	1.14537033
31	PLK3	1.11257668
32	SIK3	1.10493781
33	GRK1	1.09899804
34	SGK2	1.06732913
35	DYRK2	1.06182033
36	OXSR1	1.04197226
37	EIF2AK3	1.03812110
38	BRSK2	1.03453518
39	MAP2K7	1.03291668
40	STK39	1.02935996
41	ACVR1B	1.02659181
42	CSNK1G2	1.02651260
43	PLK1	1.00558565
44	STK16	0.99885416
45	MAP4K2	0.99291711
46	MAPKAPK3	0.99212835
47	PKN1	0.99009929
48	MKNK1	0.97362920
49	WNK4	0.93199314
50	CDK3	0.91150921
51	NEK1	0.89618828
52	MAPK13	0.88703109
53	CSNK1G3	0.87282924
54	CSNK1A1L	0.85187469
55	MINK1	0.80560744
56	ATR	0.80092484
57	BUB1	0.80069383
58	SGK223	0.79006553
59	SGK494	0.79006553
60	TGFBR1	0.78804796
61	SRPK1	0.74846118
62	PLK2	0.74143109
63	TLK1	0.73632960
64	TSSK6	0.73480825
65	FGFR2	0.68180644
66	PTK2B	0.67498680
67	PRKCG	0.67335245
68	LATS1	0.63709947
69	MAP3K9	0.60700710
70	NTRK3	0.59242254
71	BRD4	0.57139316
72	STK38L	0.54189928
73	ATM	0.54025941
74	BRSK1	0.53941784
75	PAK3	0.53446310
76	DYRK3	0.50254731
77	CHEK2	0.50226109
78	CAMK1	0.49921635
79	STK11	0.49763972
80	EIF2AK1	0.48276497
81	MAPK15	0.45369972
82	STK4	0.44429470
83	DYRK1A	0.43535492
84	NLK	0.43306146
85	TXK	0.42792101
86	PDK2	0.40220567
87	TEC	0.38779817
88	CLK1	0.38499864
89	CSNK1E	0.37859390
90	AURKB	0.35653917
91	ADRBK1	0.35241315
92	CHUK	0.34998659
93	ROCK1	0.34574360
94	AKT3	0.34222155
95	NEK2	0.32377790
96	DAPK1	0.31885576
97	SGK3	0.29537544
98	SIK2	0.27097087
99	PRKACA	0.26805004
100	PRKDC	0.26725919

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fanconi anemia pathway_Homo sapiens_hsa03460	3.11546517
2	Non-homologous end-joining_Homo sapiens_hsa03450	2.99487203
3	Homologous recombination_Homo sapiens_hsa03440	2.98493074
4	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.87996478
5	Propanoate metabolism_Homo sapiens_hsa00640	2.54278418
6	Phototransduction_Homo sapiens_hsa04744	2.54235933
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.34595286
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.31684478
9	Mismatch repair_Homo sapiens_hsa03430	2.30358052
10	RNA polymerase_Homo sapiens_hsa03020	2.29971584
11	Selenocompound metabolism_Homo sapiens_hsa00450	2.26190291
12	Sulfur relay system_Homo sapiens_hsa04122	2.07513414
13	Steroid biosynthesis_Homo sapiens_hsa00100	2.02507927
14	Nicotine addiction_Homo sapiens_hsa05033	1.95659451
15	Oxidative phosphorylation_Homo sapiens_hsa00190	1.89578965
16	Protein export_Homo sapiens_hsa03060	1.82921311
17	Butanoate metabolism_Homo sapiens_hsa00650	1.60202222
18	Parkinsons disease_Homo sapiens_hsa05012	1.56288268
19	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.52281278
20	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.51579722
21	Nitrogen metabolism_Homo sapiens_hsa00910	1.50711778
22	Basal cell carcinoma_Homo sapiens_hsa05217	1.50434989
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.47173588
24	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.42939475
25	Taste transduction_Homo sapiens_hsa04742	1.42217036
26	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.35739110
27	Basal transcription factors_Homo sapiens_hsa03022	1.34276851
28	Linoleic acid metabolism_Homo sapiens_hsa00591	1.31465462
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.29965315
30	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.29787982
31	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.27040510
32	RNA degradation_Homo sapiens_hsa03018	1.26413176
33	Ribosome_Homo sapiens_hsa03010	1.24649410
34	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.24489741
35	Tryptophan metabolism_Homo sapiens_hsa00380	1.22137721
36	Nucleotide excision repair_Homo sapiens_hsa03420	1.19523635
37	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.19074749
38	Base excision repair_Homo sapiens_hsa03410	1.17382980
39	Spliceosome_Homo sapiens_hsa03040	1.16137874
40	Huntingtons disease_Homo sapiens_hsa05016	1.13037269
41	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.11477243
42	DNA replication_Homo sapiens_hsa03030	1.09663055
43	Cell cycle_Homo sapiens_hsa04110	1.09285549
44	Pyrimidine metabolism_Homo sapiens_hsa00240	1.06332388
45	One carbon pool by folate_Homo sapiens_hsa00670	1.03284405
46	Morphine addiction_Homo sapiens_hsa05032	1.02473834
47	Purine metabolism_Homo sapiens_hsa00230	0.99773372
48	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.98515369
49	Circadian rhythm_Homo sapiens_hsa04710	0.96385317
50	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.95684668
51	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.95670558
52	Axon guidance_Homo sapiens_hsa04360	0.92912685
53	Cardiac muscle contraction_Homo sapiens_hsa04260	0.91982745
54	Caffeine metabolism_Homo sapiens_hsa00232	0.90076145
55	Alzheimers disease_Homo sapiens_hsa05010	0.89570460
56	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.86808376
57	Hippo signaling pathway_Homo sapiens_hsa04390	0.86212077
58	RNA transport_Homo sapiens_hsa03013	0.85888719
59	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.82136399
60	Peroxisome_Homo sapiens_hsa04146	0.79142098
61	GABAergic synapse_Homo sapiens_hsa04727	0.76100214
62	Wnt signaling pathway_Homo sapiens_hsa04310	0.75839922
63	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.75557696
64	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.75444482
65	beta-Alanine metabolism_Homo sapiens_hsa00410	0.72391205
66	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.70632212
67	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.69765521
68	Cocaine addiction_Homo sapiens_hsa05030	0.66741936
69	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.66145878
70	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.63306411
71	Folate biosynthesis_Homo sapiens_hsa00790	0.63175824
72	Olfactory transduction_Homo sapiens_hsa04740	0.61399535
73	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.60742627
74	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.60348039
75	Glutamatergic synapse_Homo sapiens_hsa04724	0.60204619
76	Asthma_Homo sapiens_hsa05310	0.59819246
77	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.59058568
78	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.58807245
79	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.57882100
80	Fat digestion and absorption_Homo sapiens_hsa04975	0.57773532
81	Retinol metabolism_Homo sapiens_hsa00830	0.56808706
82	Salivary secretion_Homo sapiens_hsa04970	0.56641277
83	Chemical carcinogenesis_Homo sapiens_hsa05204	0.56462615
84	Circadian entrainment_Homo sapiens_hsa04713	0.55834215
85	Lysine degradation_Homo sapiens_hsa00310	0.52777756
86	Serotonergic synapse_Homo sapiens_hsa04726	0.52661587
87	ABC transporters_Homo sapiens_hsa02010	0.51821655
88	Metabolic pathways_Homo sapiens_hsa01100	0.50953486
89	Oocyte meiosis_Homo sapiens_hsa04114	0.50095705
90	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.48931749
91	Arginine and proline metabolism_Homo sapiens_hsa00330	0.47070982
92	Pyruvate metabolism_Homo sapiens_hsa00620	0.47006023
93	Proteasome_Homo sapiens_hsa03050	0.45238372
94	Ether lipid metabolism_Homo sapiens_hsa00565	0.44529100
95	p53 signaling pathway_Homo sapiens_hsa04115	0.43236555
96	Dopaminergic synapse_Homo sapiens_hsa04728	0.41840575
97	Fatty acid metabolism_Homo sapiens_hsa01212	0.40968526
98	Regulation of autophagy_Homo sapiens_hsa04140	0.39971809
99	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.38856125
100	Long-term depression_Homo sapiens_hsa04730	0.38788569

PGAM1P9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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