PGAM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Phosphoglycerate mutase (PGAM) catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. The PGAM is a dimeric enzyme containing, in different tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). This gene encodes muscle-specific PGAM subunit. Mutations in this gene cause muscle phosphoglycerate mutase eficiency, also known as glycogen storage disease X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)9.08670798
2actin-mediated cell contraction (GO:0070252)8.62667683
3regulation of skeletal muscle contraction (GO:0014819)7.97192453
4myofibril assembly (GO:0030239)7.94578136
5cardiac myofibril assembly (GO:0055003)7.94160225
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.19689903
7cardiac muscle contraction (GO:0060048)6.76106381
8actin filament-based movement (GO:0030048)6.37371336
9sarcoplasmic reticulum calcium ion transport (GO:0070296)6.36264112
10positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.31420367
11negative regulation of potassium ion transmembrane transport (GO:1901380)6.26474057
12* striated muscle contraction (GO:0006941)6.14408832
13plasma membrane repair (GO:0001778)6.12877652
14cardiac muscle cell development (GO:0055013)6.08217991
15tricarboxylic acid cycle (GO:0006099)6.02016109
16actomyosin structure organization (GO:0031032)6.00810694
17regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.94120106
18skeletal muscle contraction (GO:0003009)5.79702363
19heart contraction (GO:0060047)5.78235971
20heart process (GO:0003015)5.78235971
21skeletal muscle fiber development (GO:0048741)5.74344737
22cardiac muscle tissue morphogenesis (GO:0055008)5.72757967
23cardiac cell development (GO:0055006)5.72021454
24regulation of relaxation of muscle (GO:1901077)5.56587411
25carnitine shuttle (GO:0006853)5.28581812
26muscle tissue morphogenesis (GO:0060415)5.26878866
27cardiac muscle hypertrophy (GO:0003300)5.24662177
28myotube cell development (GO:0014904)5.20711687
29regulation of actin filament-based movement (GO:1903115)5.16640956
30striated muscle hypertrophy (GO:0014897)5.08809002
31regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.99805843
32response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.94672223
33adult heart development (GO:0007512)4.87643130
34regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.85538337
35ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.85325039
36regulation of cell communication by electrical coupling (GO:0010649)4.84907168
37regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.82651625
38regulation of sarcomere organization (GO:0060297)4.72274706
39mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.71395585
40regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.70814645
41regulation of acyl-CoA biosynthetic process (GO:0050812)4.55729654
42glucan biosynthetic process (GO:0009250)4.54072947
43regulation of striated muscle contraction (GO:0006942)4.53743188
44muscle cell cellular homeostasis (GO:0046716)4.53169014
45muscle hypertrophy (GO:0014896)4.49096691
46carnitine transmembrane transport (GO:1902603)4.45717489
47heart trabecula formation (GO:0060347)4.45555227
48fatty acid transmembrane transport (GO:1902001)4.44511887
49skeletal muscle adaptation (GO:0043501)4.41154005
50oxidative phosphorylation (GO:0006119)4.36744461
51skeletal muscle tissue development (GO:0007519)4.34040027
52energy coupled proton transport, down electrochemical gradient (GO:0015985)4.33304911
53ATP synthesis coupled proton transport (GO:0015986)4.33304911
54ventricular cardiac muscle cell action potential (GO:0086005)4.30125038
55* muscle contraction (GO:0006936)4.28187287
56response to inactivity (GO:0014854)4.25783354
57amino-acid betaine transport (GO:0015838)4.18569148
58carnitine transport (GO:0015879)4.18569148
59regulation of cofactor metabolic process (GO:0051193)4.18336888
60regulation of coenzyme metabolic process (GO:0051196)4.18336888
61pyrimidine ribonucleoside catabolic process (GO:0046133)4.11858888
62regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.11642889
63regulation of the force of heart contraction (GO:0002026)4.11205967
64striated muscle atrophy (GO:0014891)4.04369536
65striated muscle cell development (GO:0055002)4.02485346
66cytidine deamination (GO:0009972)4.01627065
67cytidine metabolic process (GO:0046087)4.01627065
68cytidine catabolic process (GO:0006216)4.01627065
69polysaccharide catabolic process (GO:0000272)3.99480710
70skeletal muscle tissue regeneration (GO:0043403)3.95185904
71respiratory electron transport chain (GO:0022904)3.95056926
722-oxoglutarate metabolic process (GO:0006103)3.92268603
73mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.92249790
74creatine metabolic process (GO:0006600)3.91990544
75regulation of membrane repolarization (GO:0060306)3.91742870
76* muscle system process (GO:0003012)3.91662392
77striated muscle adaptation (GO:0014888)3.86425449
78electron transport chain (GO:0022900)3.86405520
79glycogen metabolic process (GO:0005977)3.85964250
80muscle adaptation (GO:0043500)3.83627788
81regulation of ATP catabolic process (GO:1903289)3.81142643
82regulation of ATPase activity (GO:0043462)3.81142643
83negative regulation of protein localization to cell surface (GO:2000009)3.80003998
84fructose metabolic process (GO:0006000)3.79042628
85cellular glucan metabolic process (GO:0006073)3.78591954
86glucan metabolic process (GO:0044042)3.78591954
87regulation of calcium ion transmembrane transport (GO:1903169)3.77756265
88regulation of calcium ion transmembrane transporter activity (GO:1901019)3.77756265
89muscle hypertrophy in response to stress (GO:0003299)3.75067070
90cardiac muscle adaptation (GO:0014887)3.75067070
91cardiac muscle hypertrophy in response to stress (GO:0014898)3.75067070
92bundle of His cell to Purkinje myocyte communication (GO:0086069)3.73806607
93negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.72933207
94response to activity (GO:0014823)3.72442205
95muscle atrophy (GO:0014889)3.69562433
96muscle cell fate commitment (GO:0042693)3.69377798
97glycogen catabolic process (GO:0005980)3.69259919
98muscle organ development (GO:0007517)3.68275264
99muscle structure development (GO:0061061)3.67673151
100negative regulation of calcium ion transmembrane transport (GO:1903170)3.62424244
101negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.62424244
102regulation of cardioblast differentiation (GO:0051890)3.61887416
103muscle fiber development (GO:0048747)3.60683963
104response to muscle activity (GO:0014850)3.57032581
105negative regulation of striated muscle cell apoptotic process (GO:0010664)3.54785907
106regulation of myoblast differentiation (GO:0045661)3.49798244
107positive regulation of myotube differentiation (GO:0010831)3.47837560
108negative regulation of skeletal muscle tissue development (GO:0048642)3.44220493
109muscle cell development (GO:0055001)3.44039923
110glucan catabolic process (GO:0009251)3.43571657
111ATP biosynthetic process (GO:0006754)3.40057616
112positive regulation of cation channel activity (GO:2001259)3.39063493
113regulation of muscle contraction (GO:0006937)3.36975546
114NADH metabolic process (GO:0006734)3.36043204
115positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.35979922
116regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.34338562
117relaxation of muscle (GO:0090075)3.33523879
118negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.33427138
119regulation of muscle system process (GO:0090257)3.32859268
120regulation of sulfur metabolic process (GO:0042762)3.32360253
121negative regulation of potassium ion transport (GO:0043267)3.29430871
122AMP metabolic process (GO:0046033)3.26426373
123negative regulation of muscle hypertrophy (GO:0014741)3.25245494
124ventricular cardiac muscle cell development (GO:0055015)3.23784452
125regulation of heart rate (GO:0002027)3.22609281
126cardiac muscle cell action potential involved in contraction (GO:0086002)3.22039118
127cellular polysaccharide catabolic process (GO:0044247)3.21210237
128cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.20128399
129membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.20003317
130glycogen biosynthetic process (GO:0005978)3.19805630
131muscle organ morphogenesis (GO:0048644)3.14094477
132* gluconeogenesis (GO:0006094)3.13883741
133striated muscle tissue development (GO:0014706)3.12683909
134muscle filament sliding (GO:0030049)10.4167694
135actin-myosin filament sliding (GO:0033275)10.4167694

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.37859958
2EP300_21415370_ChIP-Seq_HL-1_Mouse4.76697492
3* ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.49542652
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.49469474
5TBX20_22328084_ChIP-Seq_HEART_Mouse3.91527708
6TBX20_22080862_ChIP-Seq_HEART_Mouse3.91527708
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.64792993
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.48434660
9MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.26898772
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.86844426
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.83136341
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.79371631
13EZH2_22144423_ChIP-Seq_EOC_Human2.71975200
14ZNF263_19887448_ChIP-Seq_K562_Human2.38620508
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.33537919
16ZNF274_21170338_ChIP-Seq_K562_Hela2.32370279
17GATA4_21415370_ChIP-Seq_HL-1_Mouse2.27434922
18ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.12450658
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.07383796
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.02304030
21* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.95618411
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.94909306
23NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.85228847
24EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.76339363
25* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.63435321
26* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.62020726
27VDR_22108803_ChIP-Seq_LS180_Human1.56189304
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55556280
29CTCF_27219007_Chip-Seq_Bcells_Human1.49034490
30PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.48424770
31IGF1R_20145208_ChIP-Seq_DFB_Human1.45204742
32SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42871242
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.37458416
34DROSHA_22980978_ChIP-Seq_HELA_Human1.34443451
35AR_21572438_ChIP-Seq_LNCaP_Human1.29461771
36OCT4_20526341_ChIP-Seq_ESCs_Human1.29102662
37SMC3_22415368_ChIP-Seq_MEFs_Mouse1.28738130
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.28053085
39TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27734880
40EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22270130
41ISL1_27105846_Chip-Seq_CPCs_Mouse1.20953865
42TP63_22573176_ChIP-Seq_HFKS_Human1.18324906
43NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.17984663
44HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17707041
45* YY1_22570637_ChIP-Seq_MALME-3M_Human1.17153480
46EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16468490
47* SPI1_20517297_ChIP-Seq_HL60_Human1.13593139
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.10763098
49FOXH1_21741376_ChIP-Seq_ESCs_Human1.10575804
50NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10436398
51RARB_27405468_Chip-Seq_BRAIN_Mouse1.09462790
52MYC_27129775_Chip-Seq_CORNEA_Mouse1.07661404
53AUTS2_25519132_ChIP-Seq_293T-REX_Human1.07384452
54MYC_19829295_ChIP-Seq_ESCs_Human1.07343072
55NANOG_20526341_ChIP-Seq_ESCs_Human1.03466120
56E2F1_20622854_ChIP-Seq_HELA_Human1.02357588
57MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02308854
58WDR5_24793694_ChIP-Seq_LNCAP_Human1.01796451
59TDRD3_21172665_ChIP-Seq_MCF-7_Human1.00563567
60CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.00559318
61PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00490829
62STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.00169655
63GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.99658649
64* BCL6_27268052_Chip-Seq_Bcells_Human0.98851362
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98577467
66ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98195946
67RAC3_21632823_ChIP-Seq_H3396_Human0.97845115
68SRF_21415370_ChIP-Seq_HL-1_Mouse0.95726146
69THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95411436
70GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.95070700
71* BCOR_27268052_Chip-Seq_Bcells_Human0.94167112
72CSB_26484114_Chip-Seq_FIBROBLAST_Human0.93722852
73* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.93624631
74RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93572824
75MTF2_20144788_ChIP-Seq_MESCs_Mouse0.92676155
76HTT_18923047_ChIP-ChIP_STHdh_Human0.92223171
77* LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.91558646
78GBX2_23144817_ChIP-Seq_PC3_Human0.91100651
79SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88730374
80RXR_22158963_ChIP-Seq_LIVER_Mouse0.88468992
81NFIB_24661679_ChIP-Seq_LUNG_Mouse0.86990789
82P68_20966046_ChIP-Seq_HELA_Human0.86585954
83TRIM28_21343339_ChIP-Seq_HEK293_Human0.85919097
84CTCF_21964334_ChIP-Seq_BJAB-B_Human0.85786487
85KDM2B_26808549_Chip-Seq_DND41_Human0.84063252
86EZH2_27304074_Chip-Seq_ESCs_Mouse0.84032974
87SUZ12_27294783_Chip-Seq_NPCs_Mouse0.83953192
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83377809
89ZFP281_18757296_ChIP-ChIP_E14_Mouse0.82735636
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.82586436
91CBP_20019798_ChIP-Seq_JUKART_Human0.82586436
92STAT3_1855785_ChIP-Seq_MESCs_Mouse0.82224342
93SOX2_21211035_ChIP-Seq_LN229_Gbm0.82078919
94P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.81938619
95GF1_26923725_Chip-Seq_HPCs_Mouse0.81451427
96* GATA1_19941827_ChIP-Seq_MEL_Mouse0.81216134
97DNAJC2_21179169_ChIP-ChIP_NT2_Human0.81010251
98SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.81005998
99STAT6_21828071_ChIP-Seq_BEAS2B_Human0.80950937
100RBPJ_22232070_ChIP-Seq_NCS_Mouse0.80945154
101GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.80248429
102SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.80037991
103JARID2_20075857_ChIP-Seq_MESCs_Mouse0.79863393
104ERG_20517297_ChIP-Seq_VCAP_Human0.79412031
105FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.79364947
106* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79226901
107ELF1_20517297_ChIP-Seq_JURKAT_Human0.79127245
108GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.78418218
109MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.77928867
110CLOCK_20551151_ChIP-Seq_293T_Human0.77675108
111P53_22127205_ChIP-Seq_FIBROBLAST_Human0.77655575
112P53_21459846_ChIP-Seq_SAOS-2_Human0.77640607
113PPARA_22158963_ChIP-Seq_LIVER_Mouse0.77356110
114CRX_20693478_ChIP-Seq_RETINA_Mouse0.76799579
115EZH2_18974828_ChIP-Seq_MESCs_Mouse0.76205141
116RNF2_18974828_ChIP-Seq_MESCs_Mouse0.76205141
117CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.76085996
118TP53_20018659_ChIP-ChIP_R1E_Mouse0.75938426
119TET1_21451524_ChIP-Seq_MESCs_Mouse0.75787037
120RAD21_21589869_ChIP-Seq_MESCs_Mouse0.75483150
121ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.75443398
122SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75408150
123TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.75263318
124TBX5_21415370_ChIP-Seq_HL-1_Mouse0.74866870
125SOX2_22085726_ChIP-Seq_NPCs_Mouse0.74038869
126SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.73966675
127RUNX1_27514584_Chip-Seq_MCF-7_Human0.73961385
128CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73850667
129CJUN_26792858_Chip-Seq_BT549_Human0.73821934
130ERA_21632823_ChIP-Seq_H3396_Human0.73403817
131PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.72975340
132TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.72972452
133NR3C1_23031785_ChIP-Seq_PC12_Mouse0.72905611
134STAT1_20625510_ChIP-Seq_HELA_Human0.72418969
135SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.72277524
136EZH2_27294783_Chip-Seq_NPCs_Mouse0.72065143
137LXR_22158963_ChIP-Seq_LIVER_Mouse0.71699789
138GATA6_21074721_ChIP-Seq_CACO-2_Human0.71454380
139KLF5_20875108_ChIP-Seq_MESCs_Mouse0.71377380
140CBP_21632823_ChIP-Seq_H3396_Human0.71134381
141LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.70894191
142SMC1_22415368_ChIP-Seq_MEFs_Mouse0.70696167
143MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.70659791
144PCGF2_27294783_Chip-Seq_ESCs_Mouse0.70196677
145* OCT4_19829295_ChIP-Seq_ESCs_Human0.70092376
146RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.69993316
147CTCF_21964334_Chip-Seq_Bcells_Human0.68615467
148SA1_27219007_Chip-Seq_Bcells_Human0.68565227

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.94850783
2MP0002837_dystrophic_cardiac_calcinosis5.57023327
3MP0000749_muscle_degeneration5.47912085
4MP0000751_myopathy5.27927379
5MP0004084_abnormal_cardiac_muscle4.98810319
6MP0004036_abnormal_muscle_relaxation4.64934700
7MP0004145_abnormal_muscle_electrophysio4.44077829
8MP0004215_abnormal_myocardial_fiber3.60432078
9MP0005330_cardiomyopathy3.47973433
10MP0004087_abnormal_muscle_fiber3.43817400
11MP0002106_abnormal_muscle_physiology3.24808985
12MP0005620_abnormal_muscle_contractility3.09134182
13MP0002269_muscular_atrophy2.97114507
14MP0002972_abnormal_cardiac_muscle2.89921710
15MP0000747_muscle_weakness2.87244482
16MP0000750_abnormal_muscle_regeneration2.82111531
17MP0000759_abnormal_skeletal_muscle2.64578763
18MP0005369_muscle_phenotype2.63465921
19MP0004130_abnormal_muscle_cell2.44095120
20MP0010630_abnormal_cardiac_muscle2.42103584
21MP0008775_abnormal_heart_ventricle2.41295410
22MP0003137_abnormal_impulse_conducting2.25916766
23MP0004233_abnormal_muscle_weight2.24032699
24MP0001544_abnormal_cardiovascular_syste2.23171970
25MP0005385_cardiovascular_system_phenoty2.23171970
26MP0004484_altered_response_of2.13086283
27MP0006036_abnormal_mitochondrial_physio2.07010981
28MP0003221_abnormal_cardiomyocyte_apopto2.06369332
29MP0005410_abnormal_fertilization1.99013605
30MP0006138_congestive_heart_failure1.98370570
31MP0003950_abnormal_plasma_membrane1.80283360
32MP0004085_abnormal_heartbeat1.69847996
33MP0003828_pulmonary_edema1.68435362
34MP0002332_abnormal_exercise_endurance1.67289097
35MP0004510_myositis1.61396649
36MP0002127_abnormal_cardiovascular_syste1.59758520
37MP0005670_abnormal_white_adipose1.29535364
38MP0005666_abnormal_adipose_tissue1.23114274
39MP0004270_analgesia1.22479080
40MP0006035_abnormal_mitochondrial_morpho1.20624103
41MP0003567_abnormal_fetal_cardiomyocyte1.19708674
42MP0002234_abnormal_pharynx_morphology1.16373718
43MP0005451_abnormal_body_composition1.15567977
44MP0002108_abnormal_muscle_morphology1.14929820
45MP0000733_abnormal_muscle_development1.11871269
46MP0000266_abnormal_heart_morphology1.06812121
47MP0003806_abnormal_nucleotide_metabolis0.96009782
48MP0005266_abnormal_metabolism0.90916193
49MP0001661_extended_life_span0.89853706
50MP0000343_altered_response_to0.88633927
51MP0004185_abnormal_adipocyte_glucose0.82387518
52MP0002822_catalepsy0.77779564
53MP0005375_adipose_tissue_phenotype0.76505879
54MP0009780_abnormal_chondrocyte_physiolo0.74076153
55MP0003279_aneurysm0.72928903
56MP0000230_abnormal_systemic_arterial0.67895392
57MP0002971_abnormal_brown_adipose0.66486390
58MP0002128_abnormal_blood_circulation0.63192830
59MP0004043_abnormal_pH_regulation0.60333547
60MP0003045_fibrosis0.57493520
61MP0005165_increased_susceptibility_to0.57040957
62MP0005623_abnormal_meninges_morphology0.54547505
63MP0003879_abnormal_hair_cell0.51856268
64MP0003698_abnormal_male_reproductive0.51758146
65MP0010368_abnormal_lymphatic_system0.51188370
66MP0003566_abnormal_cell_adhesion0.49660581
67MP0003705_abnormal_hypodermis_morpholog0.48481667
68MP0001299_abnormal_eye_distance/0.48363732
69MP0005167_abnormal_blood-brain_barrier0.46599379
70MP0008569_lethality_at_weaning0.44135152
71MP0001879_abnormal_lymphatic_vessel0.43952114
72MP0000013_abnormal_adipose_tissue0.43727902
73MP0002925_abnormal_cardiovascular_devel0.43359145
74MP0000372_irregular_coat_pigmentation0.42699338
75MP0004272_abnormal_basement_membrane0.42567006
76MP0005275_abnormal_skin_tensile0.42479976
77MP0003984_embryonic_growth_retardation0.41576352
78MP0002088_abnormal_embryonic_growth/wei0.41310356
79MP0003948_abnormal_gas_homeostasis0.39216851
80MP0005319_abnormal_enzyme/_coenzyme0.39107307
81MP0001929_abnormal_gametogenesis0.39000317
82MP0009840_abnormal_foam_cell0.38952522
83MP0004134_abnormal_chest_morphology0.37676074
84MP0004147_increased_porphyrin_level0.37508606
85MP0000767_abnormal_smooth_muscle0.37420364
86MP0003656_abnormal_erythrocyte_physiolo0.37219121
87MP0005166_decreased_susceptibility_to0.37202309
88MP0000762_abnormal_tongue_morphology0.37016144
89MP0002638_abnormal_pupillary_reflex0.36818578
90MP0010030_abnormal_orbit_morphology0.36623214
91MP0001784_abnormal_fluid_regulation0.35891287
92MP0002078_abnormal_glucose_homeostasis0.34804152
93MP0001614_abnormal_blood_vessel0.30892049
94MP0000003_abnormal_adipose_tissue0.30404583
95MP0009384_cardiac_valve_regurgitation0.29217474
96MP0003941_abnormal_skin_development0.27038898
97MP0004142_abnormal_muscle_tone0.27007428
98MP0005083_abnormal_biliary_tract0.26838990
99MP0005423_abnormal_somatic_nervous0.26011257
100MP0003122_maternal_imprinting0.25534584
101MP0005584_abnormal_enzyme/coenzyme_acti0.25416915
102MP0002114_abnormal_axial_skeleton0.25200915
103MP0008961_abnormal_basal_metabolism0.25139179
104MP0008004_abnormal_stomach_pH0.25070026
105MP0001727_abnormal_embryo_implantation0.24275200
106MP0003385_abnormal_body_wall0.23194324
107MP0005332_abnormal_amino_acid0.22730552
108MP0002909_abnormal_adrenal_gland0.22512024
109MP0009250_abnormal_appendicular_skeleto0.22455465
110MP0001984_abnormal_olfaction0.22135921
111MP0002066_abnormal_motor_capabilities/c0.21669275
112MP0005334_abnormal_fat_pad0.21597618
113MP0002734_abnormal_mechanical_nocicepti0.21473174
114MP0005380_embryogenesis_phenotype0.21348106
115MP0001672_abnormal_embryogenesis/_devel0.21348106
116MP0005376_homeostasis/metabolism_phenot0.21226846
117MP0000358_abnormal_cell_content/0.20484976
118MP0009672_abnormal_birth_weight0.20155473
119MP0001765_abnormal_ion_homeostasis0.19949061
120MP0005595_abnormal_vascular_smooth0.19854048
121MP0008877_abnormal_DNA_methylation0.19309502
122MP0002896_abnormal_bone_mineralization0.18919513
123MP0005452_abnormal_adipose_tissue0.18860627
124MP0005535_abnormal_body_temperature0.18132478
125MP0005187_abnormal_penis_morphology0.18050599
126MP0001529_abnormal_vocalization0.17801667
127MP0001943_abnormal_respiration0.17685684
128MP0004924_abnormal_behavior0.17319088
129MP0005386_behavior/neurological_phenoty0.17319088
130MP0001346_abnormal_lacrimal_gland0.16666446
131MP0008438_abnormal_cutaneous_collagen0.16642586
132MP0008874_decreased_physiological_sensi0.14566486

Predicted human phenotypes

RankGene SetZ-score
1Calf muscle hypertrophy (HP:0008981)7.23765040
2Muscle hypertrophy of the lower extremities (HP:0008968)7.16115832
3* Exercise-induced muscle cramps (HP:0003710)7.00896886
4* Exercise-induced myalgia (HP:0003738)7.00476292
5Sudden death (HP:0001699)6.45862168
6Muscle fiber inclusion bodies (HP:0100299)6.06114190
7Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.90124869
8Muscle fiber splitting (HP:0003555)5.69656152
9Hyporeflexia of lower limbs (HP:0002600)5.57481603
10Abnormality of the calf musculature (HP:0001430)5.36477418
11Nemaline bodies (HP:0003798)5.36364125
12Ventricular tachycardia (HP:0004756)5.33987134
13Abnormality of the left ventricular outflow tract (HP:0011103)5.25878802
14Subaortic stenosis (HP:0001682)5.25878802
15Type 1 muscle fiber predominance (HP:0003803)5.09446768
16* Myoglobinuria (HP:0002913)5.04255903
17EMG: myopathic abnormalities (HP:0003458)4.80500029
18Difficulty running (HP:0009046)4.40206849
19Lipoatrophy (HP:0100578)4.38736278
20Atrial fibrillation (HP:0005110)4.38357545
21Asymmetric septal hypertrophy (HP:0001670)4.13863261
22Increased connective tissue (HP:0009025)4.10449855
23Primary atrial arrhythmia (HP:0001692)4.06780131
24* Rhabdomyolysis (HP:0003201)4.01720273
25Distal arthrogryposis (HP:0005684)3.93996818
26Supraventricular tachycardia (HP:0004755)3.92900139
27Supraventricular arrhythmia (HP:0005115)3.83824150
28Muscle stiffness (HP:0003552)3.76121206
29Myotonia (HP:0002486)3.75906622
30Dilated cardiomyopathy (HP:0001644)3.65815806
31Myopathic facies (HP:0002058)3.54355171
32Bundle branch block (HP:0011710)3.51305618
33Round ear (HP:0100830)3.41811713
34Right ventricular cardiomyopathy (HP:0011663)3.39508543
35Neck muscle weakness (HP:0000467)3.33083505
36Palpitations (HP:0001962)3.30036516
37Difficulty climbing stairs (HP:0003551)3.27621188
38Ulnar deviation of the wrist (HP:0003049)3.19570155
39Prolonged QT interval (HP:0001657)3.16183528
40Syncope (HP:0001279)3.10198343
41Areflexia of lower limbs (HP:0002522)3.09187054
42Ventricular arrhythmia (HP:0004308)3.08405605
43Rimmed vacuoles (HP:0003805)3.06831132
44Abnormality of skeletal muscle fiber size (HP:0012084)2.96859223
45Distal lower limb muscle weakness (HP:0009053)2.95392381
46Heart block (HP:0012722)2.86029436
47Increased variability in muscle fiber diameter (HP:0003557)2.83810997
48Acute necrotizing encephalopathy (HP:0006965)2.81321934
49Abnormal mitochondria in muscle tissue (HP:0008316)2.78712028
50Abnormal atrioventricular conduction (HP:0005150)2.68491347
51Generalized muscle weakness (HP:0003324)2.68200714
52EMG: neuropathic changes (HP:0003445)2.66871651
53Distal lower limb amyotrophy (HP:0008944)2.64490566
54Left ventricular hypertrophy (HP:0001712)2.55570969
55Centrally nucleated skeletal muscle fibers (HP:0003687)2.48616867
56Double outlet right ventricle (HP:0001719)2.45650266
57Congenital malformation of the right heart (HP:0011723)2.45650266
58Ventricular fibrillation (HP:0001663)2.45092434
59Atrioventricular block (HP:0001678)2.40859542
60Abnormality of the shoulder girdle musculature (HP:0001435)2.38437833
61Calcaneovalgus deformity (HP:0001848)2.38257632
62Hepatic necrosis (HP:0002605)2.37355364
63Acute encephalopathy (HP:0006846)2.35108345
64Fetal akinesia sequence (HP:0001989)2.34031587
65Abnormal EKG (HP:0003115)2.33898653
66Absent phalangeal crease (HP:0006109)2.33362183
67Progressive macrocephaly (HP:0004481)2.30095820
68Muscular dystrophy (HP:0003560)2.29633156
69Mildly elevated creatine phosphokinase (HP:0008180)2.29590457
70Slender build (HP:0001533)2.22546321
71Ragged-red muscle fibers (HP:0003200)2.20494288
72* Exercise intolerance (HP:0003546)2.20425656
73Gowers sign (HP:0003391)2.20175471
74Mitochondrial inheritance (HP:0001427)2.18356008
75Abnormality of the calcaneus (HP:0008364)2.15847028
76Palmoplantar keratoderma (HP:0000982)2.15747724
77Deformed tarsal bones (HP:0008119)2.13944050
78Frequent falls (HP:0002359)2.13352949
79Hepatocellular necrosis (HP:0001404)2.12078841
80Conjunctival hamartoma (HP:0100780)2.11323399
81Hip contracture (HP:0003273)2.10008947
82Increased CSF lactate (HP:0002490)2.09609580
83Limb-girdle muscle atrophy (HP:0003797)2.06927806
84Waddling gait (HP:0002515)2.06270348
85Respiratory insufficiency due to muscle weakness (HP:0002747)2.00910522
86Lower limb amyotrophy (HP:0007210)2.00784907
87Abnormal finger flexion creases (HP:0006143)1.99760869
88Facial diplegia (HP:0001349)1.98829879
89Abnormality of the foot musculature (HP:0001436)1.98642805
90Abnormality of the neuromuscular junction (HP:0003398)1.97899474
91Fatigable weakness (HP:0003473)1.97899474
92Cerebral edema (HP:0002181)1.94440113
93Proximal amyotrophy (HP:0007126)1.91333173
94Increased muscle lipid content (HP:0009058)1.90211994
95Ketoacidosis (HP:0001993)1.90082171
96Foot dorsiflexor weakness (HP:0009027)1.87388069
97Scapular winging (HP:0003691)1.86763574
98Bulbar palsy (HP:0001283)1.84422795
99Progressive muscle weakness (HP:0003323)1.83845947
100Weak cry (HP:0001612)1.83037117
101Malignant hyperthermia (HP:0002047)1.81612937
102Pheochromocytoma (HP:0002666)1.81120231
103Hypoplastic ischia (HP:0003175)1.80687055
104Lactic acidosis (HP:0003128)1.80538667
105Increased serum pyruvate (HP:0003542)1.80063466
106Abnormality of glycolysis (HP:0004366)1.80063466
107Abnormality of the musculature of the pelvis (HP:0001469)1.79858136
108Abnormality of the hip-girdle musculature (HP:0001445)1.79858136
109Limb-girdle muscle weakness (HP:0003325)1.79828578
110Spinal rigidity (HP:0003306)1.79651581
111Shoulder girdle muscle weakness (HP:0003547)1.74937576
112Pelvic girdle muscle weakness (HP:0003749)1.73291092
113Hyperkalemia (HP:0002153)1.72837168
114Nonprogressive disorder (HP:0003680)1.69244487
115Steppage gait (HP:0003376)1.63670074
116Increased intramyocellular lipid droplets (HP:0012240)1.61462760
117Popliteal pterygium (HP:0009756)1.56566963
118Type 2 muscle fiber atrophy (HP:0003554)1.52411850
119Metatarsus adductus (HP:0001840)1.51412809
120Long clavicles (HP:0000890)1.49789963
121Paralysis (HP:0003470)1.48441185

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN7.49890017
2TTN5.40945668
3PDK44.47542587
4PDK34.47542587
5PHKG24.01887037
6PHKG14.01887037
7MYLK3.36044365
8PDK22.78046080
9DMPK2.28879832
10PIK3CA2.28241308
11STK242.24775754
12PKN22.13242881
13NEK12.07435614
14MUSK2.01507665
15BCKDK1.97518468
16ZAK1.95684031
17PINK11.88611978
18LMTK21.85189872
19NME11.72798492
20TRIB31.67033643
21MAP2K31.56856657
22STK38L1.55896609
23PIK3CG1.49202616
24TESK11.46032549
25PRKD31.27489576
26MAP3K71.19267475
27WNK41.14886887
28TIE11.07806650
29EEF2K1.06983947
30MAPK121.05047271
31ILK1.02293053
32PTK2B1.01073272
33MARK10.99942530
34ICK0.94945049
35CCNB10.91152329
36TRPM70.83581205
37CDC42BPA0.82114897
38PRKAA10.81757540
39MAP3K30.78896047
40MOS0.78401659
41LIMK10.74932458
42PAK30.74778271
43STK380.73041037
44PRKAA20.72226354
45ROCK10.70797189
46STK390.70400409
47CAMK2D0.69926180
48MAP2K60.69198757
49PRKD10.69055454
50MAPKAPK30.69054892
51MAP3K50.68537981
52FLT30.68297703
53MAP3K130.60926944
54ERBB30.60623622
55GRK70.56485994
56MAP2K40.55166981
57STK40.54929432
58DAPK30.54356045
59NEK90.53669386
60WNK10.49423907
61MAPK40.49300824
62PKN10.47809138
63KSR20.46373279
64SGK30.44849272
65CAMK2B0.44410327
66CAMK2G0.41707745
67PRKACB0.40703838
68SGK20.40611264
69MAP3K10.40600029
70MAP2K10.39933048
71RIPK10.39717952
72ARAF0.37824281
73PDK10.36262351
74CAMK10.35187882
75AKT20.34646672
76CAMK2A0.33370362
77MAP3K100.30335551
78PRKACA0.29819551
79ROCK20.29733218
80RPS6KB10.29137924
81SGK2230.28480719
82SGK4940.28480719
83INSRR0.27903008
84PRKG10.26688944
85STK30.26429157
86PDPK10.25644697
87RPS6KL10.24725308
88RPS6KC10.24725308
89MAPK130.24704381
90CAMK40.23349883
91TBK10.22356113
92MAPK100.21072210
93MAPK110.19578134
94PRKACG0.19040250
95RPS6KA60.18793698
96MAP3K60.17577908
97KDR0.17178106
98MAP3K110.15630140
99MARK20.15404369
100PAK20.15272756
101PDGFRA0.15001173
102SGK10.14815628
103RPS6KA10.14212406
104DAPK20.13409287
105LATS20.12342650
106PRKG20.11860618
107RPS6KB20.11769578
108TAOK20.11763142
109TGFBR20.11541979
110MARK30.11529188
111RPS6KA30.11307188
112RAF10.11048665
113EPHB20.09263570
114MAP3K90.09236173
115DYRK1B0.08319756
116LATS10.08056517
117NME20.07906550
118FGFR10.07839010
119ZAP700.07501355
120BRAF0.07006591
121SIK10.06808736
122MTOR0.06012783
123PTK60.05909830
124PRKCQ0.05883735
125TAOK10.05256445
126EPHB10.04153719
127RPS6KA20.03926662
128MAPK70.03747867
129PRKCH0.03729713
130FER0.03127982

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.62995179
2Cardiac muscle contraction_Homo sapiens_hsa042605.09770987
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.93335603
4Dilated cardiomyopathy_Homo sapiens_hsa054143.63724577
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.58027626
6Parkinsons disease_Homo sapiens_hsa050123.53134851
7Oxidative phosphorylation_Homo sapiens_hsa001903.40688999
8Propanoate metabolism_Homo sapiens_hsa006403.13758332
9Alzheimers disease_Homo sapiens_hsa050102.65430234
10* Carbon metabolism_Homo sapiens_hsa012002.56337952
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.54202459
12Huntingtons disease_Homo sapiens_hsa050162.44223083
13Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.32091280
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.29803387
15Fatty acid degradation_Homo sapiens_hsa000712.24379865
16Pyruvate metabolism_Homo sapiens_hsa006202.23046493
17* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.19289120
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.88621825
19Fatty acid metabolism_Homo sapiens_hsa012121.73437783
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.66424428
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59101080
22Starch and sucrose metabolism_Homo sapiens_hsa005001.51801161
23* Glucagon signaling pathway_Homo sapiens_hsa049221.49208426
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.42255927
25Fructose and mannose metabolism_Homo sapiens_hsa000511.34207830
26Viral myocarditis_Homo sapiens_hsa054161.32767603
27* Biosynthesis of amino acids_Homo sapiens_hsa012301.26378356
28Galactose metabolism_Homo sapiens_hsa000521.23165005
29cGMP-PKG signaling pathway_Homo sapiens_hsa040221.19705717
30Insulin resistance_Homo sapiens_hsa049311.12831282
31Insulin signaling pathway_Homo sapiens_hsa049101.07568870
32Adipocytokine signaling pathway_Homo sapiens_hsa049201.00700350
33Calcium signaling pathway_Homo sapiens_hsa040200.99720901
34Oxytocin signaling pathway_Homo sapiens_hsa049210.97495373
35Tight junction_Homo sapiens_hsa045300.96466294
36Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93977517
37Nitrogen metabolism_Homo sapiens_hsa009100.91819632
38HIF-1 signaling pathway_Homo sapiens_hsa040660.90888921
39PPAR signaling pathway_Homo sapiens_hsa033200.88299036
40AMPK signaling pathway_Homo sapiens_hsa041520.83145839
41Fatty acid biosynthesis_Homo sapiens_hsa000610.81953015
42Vascular smooth muscle contraction_Homo sapiens_hsa042700.81347756
43Fatty acid elongation_Homo sapiens_hsa000620.78221490
44Pentose phosphate pathway_Homo sapiens_hsa000300.77821261
45Butanoate metabolism_Homo sapiens_hsa006500.70481547
46Focal adhesion_Homo sapiens_hsa045100.68346237
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61334097
48Circadian rhythm_Homo sapiens_hsa047100.59111076
49Arginine and proline metabolism_Homo sapiens_hsa003300.58904208
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58243213
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55286673
52* Central carbon metabolism in cancer_Homo sapiens_hsa052300.53182339
53Phenylalanine metabolism_Homo sapiens_hsa003600.49317984
54Salivary secretion_Homo sapiens_hsa049700.48020232
55Renin secretion_Homo sapiens_hsa049240.47621483
56beta-Alanine metabolism_Homo sapiens_hsa004100.39035596
57Type II diabetes mellitus_Homo sapiens_hsa049300.39023158
58* Metabolic pathways_Homo sapiens_hsa011000.37682998
59Amphetamine addiction_Homo sapiens_hsa050310.37450714
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37185154
61Gastric acid secretion_Homo sapiens_hsa049710.36215989
62Cholinergic synapse_Homo sapiens_hsa047250.35955573
63Regulation of autophagy_Homo sapiens_hsa041400.35930484
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.35047012
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34782164
66Adherens junction_Homo sapiens_hsa045200.33417232
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33151649
68Olfactory transduction_Homo sapiens_hsa047400.32327643
69Peroxisome_Homo sapiens_hsa041460.32000019
70Lysine degradation_Homo sapiens_hsa003100.31409909
71Insulin secretion_Homo sapiens_hsa049110.30138485
72Ovarian steroidogenesis_Homo sapiens_hsa049130.27945138
73Tryptophan metabolism_Homo sapiens_hsa003800.27469345
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27355987
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.26657354
76Histidine metabolism_Homo sapiens_hsa003400.26506589
77Long-term depression_Homo sapiens_hsa047300.24455921
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23987314
79Gap junction_Homo sapiens_hsa045400.23215784
80Arginine biosynthesis_Homo sapiens_hsa002200.22044534
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21659482
82Fat digestion and absorption_Homo sapiens_hsa049750.21637960
83cAMP signaling pathway_Homo sapiens_hsa040240.21461745
84Glycerolipid metabolism_Homo sapiens_hsa005610.21199777
85Linoleic acid metabolism_Homo sapiens_hsa005910.21173820
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20101193
87Tyrosine metabolism_Homo sapiens_hsa003500.19378615
88Purine metabolism_Homo sapiens_hsa002300.18617611
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.17535302
90Bile secretion_Homo sapiens_hsa049760.16873844
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.16304616
92Sulfur relay system_Homo sapiens_hsa041220.15061313
93VEGF signaling pathway_Homo sapiens_hsa043700.14407800
94Circadian entrainment_Homo sapiens_hsa047130.13380983
95Glioma_Homo sapiens_hsa052140.12548128
96Proteasome_Homo sapiens_hsa030500.12083075
97ECM-receptor interaction_Homo sapiens_hsa045120.11676746
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.11446477
99FoxO signaling pathway_Homo sapiens_hsa040680.10198944
100Proteoglycans in cancer_Homo sapiens_hsa052050.09858837
101Dopaminergic synapse_Homo sapiens_hsa047280.09853643
102Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.09837643
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.08875191
104Oocyte meiosis_Homo sapiens_hsa041140.08299929
105Amoebiasis_Homo sapiens_hsa051460.07856489
106Aldosterone synthesis and secretion_Homo sapiens_hsa049250.07663942
107mTOR signaling pathway_Homo sapiens_hsa041500.07049380
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.07006006
109GnRH signaling pathway_Homo sapiens_hsa049120.06809243
110MAPK signaling pathway_Homo sapiens_hsa040100.03600589
111Basal cell carcinoma_Homo sapiens_hsa052170.00583995
112Glycerophospholipid metabolism_Homo sapiens_hsa005640.00404240
113Arachidonic acid metabolism_Homo sapiens_hsa005900.00210838
114Melanogenesis_Homo sapiens_hsa04916-0.0265566
115Hedgehog signaling pathway_Homo sapiens_hsa04340-0.0233406
116Platelet activation_Homo sapiens_hsa04611-0.0126552
117Long-term potentiation_Homo sapiens_hsa04720-0.0037378
118Pancreatic secretion_Homo sapiens_hsa04972-0.0014790

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