PGAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene functions early in the glycosylphosphatidylinositol (GPI) biosynthetic pathway, catalyzing the inositol deacylation of GPI. The encoded protein is required for the production of GPI that can attach to proteins, and this may be an important factor in the transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi. Defects in this gene are a cause of mental retardation, autosomal recessive 42. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.24925114
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.51698419
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.39991468
4limb bud formation (GO:0060174)4.37019675
5presynaptic membrane assembly (GO:0097105)4.35651355
6dendritic spine morphogenesis (GO:0060997)4.27234806
7pyrimidine nucleobase catabolic process (GO:0006208)4.21992654
8neuron recognition (GO:0008038)4.11898983
9layer formation in cerebral cortex (GO:0021819)4.06603079
10dendrite morphogenesis (GO:0048813)4.02457205
11vocalization behavior (GO:0071625)3.98100360
12presynaptic membrane organization (GO:0097090)3.96222854
13response to pheromone (GO:0019236)3.86613703
14synaptic vesicle maturation (GO:0016188)3.84889113
15axonal fasciculation (GO:0007413)3.81093338
16regulation of synaptic vesicle exocytosis (GO:2000300)3.72416826
17establishment of mitochondrion localization (GO:0051654)3.71530760
18synaptic vesicle exocytosis (GO:0016079)3.70617149
19positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.63237906
20neural tube formation (GO:0001841)3.55327123
21central nervous system myelination (GO:0022010)3.52335491
22axon ensheathment in central nervous system (GO:0032291)3.52335491
23locomotory exploration behavior (GO:0035641)3.46956198
24regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.46737636
25protein localization to synapse (GO:0035418)3.43353203
26central nervous system projection neuron axonogenesis (GO:0021952)3.42849020
27glutamate secretion (GO:0014047)3.41278766
28postsynaptic membrane organization (GO:0001941)3.40900128
29olfactory bulb development (GO:0021772)3.37319971
30regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.36036252
31negative regulation of neurotransmitter transport (GO:0051589)3.32426310
32nucleobase catabolic process (GO:0046113)3.31354010
33regulation of glutamate receptor signaling pathway (GO:1900449)3.26950811
34organelle transport along microtubule (GO:0072384)3.26652210
35transmission of nerve impulse (GO:0019226)3.25253260
36ionotropic glutamate receptor signaling pathway (GO:0035235)3.22041915
37retinal ganglion cell axon guidance (GO:0031290)3.21452289
38proline transport (GO:0015824)3.21438623
39spinal cord development (GO:0021510)3.20965164
40synapse assembly (GO:0007416)3.17539968
41regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.16793043
42calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.14113101
43neurotransmitter secretion (GO:0007269)3.12764989
44sympathetic nervous system development (GO:0048485)3.12188989
45cell migration in hindbrain (GO:0021535)3.11886186
46cerebral cortex radially oriented cell migration (GO:0021799)3.11551812
47negative regulation of neurotransmitter secretion (GO:0046929)3.11329978
48exploration behavior (GO:0035640)3.10541518
49glutamate receptor signaling pathway (GO:0007215)3.09976932
50vesicle transport along microtubule (GO:0047496)3.09824276
51neurotransmitter-gated ion channel clustering (GO:0072578)3.09817830
52regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.09519157
53establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.09407354
54mitochondrion transport along microtubule (GO:0047497)3.09407354
55gamma-aminobutyric acid transport (GO:0015812)3.06117053
56somite development (GO:0061053)3.04102018
57apical protein localization (GO:0045176)3.01644084
58positive regulation of synapse assembly (GO:0051965)3.00113743
59establishment of nucleus localization (GO:0040023)2.94716181
60positive regulation of dendritic spine morphogenesis (GO:0061003)2.94415485
61auditory behavior (GO:0031223)2.93984859
62cerebellar granule cell differentiation (GO:0021707)2.93954829
63cerebral cortex cell migration (GO:0021795)2.92352679
64regulation of synaptic vesicle transport (GO:1902803)2.88986342
65positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.87080864
66synaptic transmission, glutamatergic (GO:0035249)2.86248753
67G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.86082557
68synapse organization (GO:0050808)2.85024440
69innervation (GO:0060384)2.84514402
70gamma-aminobutyric acid signaling pathway (GO:0007214)2.84316270
71forebrain neuron differentiation (GO:0021879)2.83266213
72behavioral response to ethanol (GO:0048149)2.83034990
73neuron-neuron synaptic transmission (GO:0007270)2.82797399
74negative regulation of dendrite development (GO:2000171)2.82385111
75central nervous system neuron axonogenesis (GO:0021955)2.81769521
76neurotransmitter transport (GO:0006836)2.75785882
77limb development (GO:0060173)2.74855706
78appendage development (GO:0048736)2.74855706
79regulation of neuronal synaptic plasticity (GO:0048168)2.74465642
80neuron migration (GO:0001764)2.74438145
81atrial cardiac muscle cell action potential (GO:0086014)2.74056151
82asymmetric protein localization (GO:0008105)2.73844100
83glycerophospholipid catabolic process (GO:0046475)2.73626089
84positive regulation of synaptic transmission, GABAergic (GO:0032230)2.73246018
85nonmotile primary cilium assembly (GO:0035058)2.72446984
86regulation of vesicle fusion (GO:0031338)2.71643162
87long-chain fatty acid biosynthetic process (GO:0042759)2.70887622
88dendrite development (GO:0016358)2.70801326
89regulation of respiratory system process (GO:0044065)2.69989770
90regulation of dendritic spine morphogenesis (GO:0061001)2.68870730
91regulation of development, heterochronic (GO:0040034)2.68551721
92synaptic vesicle endocytosis (GO:0048488)2.68536247
93mating behavior (GO:0007617)2.68476951
94axon extension (GO:0048675)2.68367264
95neuronal action potential propagation (GO:0019227)2.68289762
96response to auditory stimulus (GO:0010996)2.65889784
97regulation of synapse assembly (GO:0051963)2.65182496
98regulation of axon guidance (GO:1902667)2.65002278
99adult walking behavior (GO:0007628)2.64766391
100kidney morphogenesis (GO:0060993)2.64348879
101hippocampus development (GO:0021766)2.64069037
102homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.62353733
103hindbrain development (GO:0030902)2.61466308
104negative regulation of synaptic transmission, GABAergic (GO:0032229)2.61105923
105protein localization to cilium (GO:0061512)2.61016804
106regulation of long-term neuronal synaptic plasticity (GO:0048169)2.60759787
107epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.60510747
108mechanosensory behavior (GO:0007638)2.60306300
109regulation of calcium ion-dependent exocytosis (GO:0017158)2.59554410
110axonogenesis (GO:0007409)2.58985203
111positive regulation of membrane potential (GO:0045838)2.58482421
112negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.58361545
113neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.58304792
114dendritic spine organization (GO:0097061)2.56989591
115regulation of excitatory postsynaptic membrane potential (GO:0060079)2.56787487
116regulation of postsynaptic membrane potential (GO:0060078)2.56464297
117clathrin coat assembly (GO:0048268)2.56142589
118startle response (GO:0001964)2.55586589
119regulation of synaptic transmission, GABAergic (GO:0032228)2.55091401
120negative regulation of axon guidance (GO:1902668)2.53972719
121regulation of synapse structural plasticity (GO:0051823)2.53658742
122neuronal ion channel clustering (GO:0045161)2.52409591
123regulation of collateral sprouting (GO:0048670)2.51085854
124cornea development in camera-type eye (GO:0061303)2.50954078
125intraciliary transport (GO:0042073)2.50714964
126cardiac ventricle formation (GO:0003211)2.50029160
127regulation of synaptic transmission, glutamatergic (GO:0051966)2.49026469
128behavioral response to nicotine (GO:0035095)2.48361647
129heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.47881431
130regulation of neurotransmitter levels (GO:0001505)2.47704913
131microtubule anchoring (GO:0034453)2.47454989
132negative chemotaxis (GO:0050919)2.47290653
133fatty acid elongation (GO:0030497)2.46692064
134lateral sprouting from an epithelium (GO:0060601)2.46522427
135cerebellar Purkinje cell layer development (GO:0021680)2.45817551
136regulation of timing of cell differentiation (GO:0048505)2.45617164
137negative regulation of oligodendrocyte differentiation (GO:0048715)2.45506950
138ephrin receptor signaling pathway (GO:0048013)2.44050720
139membrane hyperpolarization (GO:0060081)2.44036686
140nerve growth factor signaling pathway (GO:0038180)2.43684748
141positive regulation of exocytosis (GO:0045921)2.43029270
142cerebellar Purkinje cell differentiation (GO:0021702)2.42807428
143negative regulation of axonogenesis (GO:0050771)2.42726986
144neuron projection extension involved in neuron projection guidance (GO:1902284)2.41854553
145axon extension involved in axon guidance (GO:0048846)2.41854553
146inner ear receptor stereocilium organization (GO:0060122)2.41703110
147membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.39844278
148negative regulation of axon extension (GO:0030517)2.39195133
149negative regulation of translation, ncRNA-mediated (GO:0040033)2.36333028
150regulation of translation, ncRNA-mediated (GO:0045974)2.36333028
151negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.36333028
152cardiac chamber formation (GO:0003207)2.34847205
153glial cell proliferation (GO:0014009)2.34648316

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.01313519
2GBX2_23144817_ChIP-Seq_PC3_Human3.75841034
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.45470650
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.51634112
5TAF15_26573619_Chip-Seq_HEK293_Human2.40839969
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.32869052
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.28151627
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.22411186
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.22068948
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.19577567
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.06471113
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.01938052
13REST_21632747_ChIP-Seq_MESCs_Mouse2.01727136
14CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99050979
15IGF1R_20145208_ChIP-Seq_DFB_Human1.98879550
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.96545762
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.94128609
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92085295
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.91761123
20AR_21572438_ChIP-Seq_LNCaP_Human1.90138119
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87913523
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.87047151
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.86832899
24* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.85722387
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.82219505
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81482631
27MTF2_20144788_ChIP-Seq_MESCs_Mouse1.81263247
28EZH2_18974828_ChIP-Seq_MESCs_Mouse1.80744751
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.80744751
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.80450005
31DROSHA_22980978_ChIP-Seq_HELA_Human1.79129288
32P300_19829295_ChIP-Seq_ESCs_Human1.77677196
33* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.77497347
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77332567
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76534695
36SMAD4_21799915_ChIP-Seq_A2780_Human1.75900973
37* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73932988
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73611164
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.70717386
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.69830717
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.67280901
42ZNF274_21170338_ChIP-Seq_K562_Hela1.66967363
43FUS_26573619_Chip-Seq_HEK293_Human1.66398486
44EZH2_27294783_Chip-Seq_ESCs_Mouse1.65037984
45ZNF217_24962896_ChIP-Seq_MCF-7_Human1.61913302
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.60965217
47* SMAD3_21741376_ChIP-Seq_EPCs_Human1.58686828
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.58463172
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.57755909
50CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.54471538
51STAT3_23295773_ChIP-Seq_U87_Human1.53346576
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.52912119
53REST_18959480_ChIP-ChIP_MESCs_Mouse1.48990786
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48585925
55BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48447761
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45440132
57* SOX2_21211035_ChIP-Seq_LN229_Gbm1.45008914
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44406473
59* RARB_27405468_Chip-Seq_BRAIN_Mouse1.44252813
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.42612006
61* FLI1_27457419_Chip-Seq_LIVER_Mouse1.41543549
62BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.40017405
63AHR_22903824_ChIP-Seq_MCF-7_Human1.39712932
64CBX2_27304074_Chip-Seq_ESCs_Mouse1.39461455
65NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38659001
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37994163
67CBP_20019798_ChIP-Seq_JUKART_Human1.35249763
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35249763
69RNF2_27304074_Chip-Seq_NSC_Mouse1.33111713
70* TCF4_23295773_ChIP-Seq_U87_Human1.29354290
71ER_23166858_ChIP-Seq_MCF-7_Human1.28762471
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28256141
73KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.28242024
74* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27006270
75AR_25329375_ChIP-Seq_VCAP_Human1.24551183
76YAP1_20516196_ChIP-Seq_MESCs_Mouse1.23876287
77TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23063695
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22770110
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22428192
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22428192
81* NANOG_18555785_Chip-Seq_ESCs_Mouse1.22136382
82MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21973265
83* RUNX2_22187159_ChIP-Seq_PCA_Human1.20996007
84SOX9_26525672_Chip-Seq_HEART_Mouse1.20380519
85* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19690567
86SMAD_19615063_ChIP-ChIP_OVARY_Human1.19599162
87* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19279651
88TP53_16413492_ChIP-PET_HCT116_Human1.17775226
89STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.15777994
90VDR_22108803_ChIP-Seq_LS180_Human1.15200868
91UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14994529
92* AR_19668381_ChIP-Seq_PC3_Human1.12903895
93TP63_19390658_ChIP-ChIP_HaCaT_Human1.12716808
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11973419
95LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11792084
96* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11511726
97* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10357078
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.08663819
99TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08377112
100TAL1_26923725_Chip-Seq_HPCs_Mouse1.07834293
101TP53_18474530_ChIP-ChIP_U2OS_Human1.07270795
102TCF4_22108803_ChIP-Seq_LS180_Human1.07077757
103MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06591831
104SOX2_16153702_ChIP-ChIP_HESCs_Human1.06270956
105P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06157270
106* CMYC_18555785_Chip-Seq_ESCs_Mouse1.05730499
107TBX3_20139965_ChIP-Seq_MESCs_Mouse1.05720719
108* P53_22387025_ChIP-Seq_ESCs_Mouse1.05388513
109TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04987704
110* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04878351
111TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04547161
112EWS_26573619_Chip-Seq_HEK293_Human1.03724750
113TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03367870
114WT1_19549856_ChIP-ChIP_CCG9911_Human1.02564524
115WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01364703
116PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00481060
117RING1B_27294783_Chip-Seq_NPCs_Mouse1.00021881
118SMAD3_21741376_ChIP-Seq_ESCs_Human0.99834443
119* E2F1_18555785_Chip-Seq_ESCs_Mouse0.99024833
120BCAT_22108803_ChIP-Seq_LS180_Human0.98656537
121VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.97472923
122EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96322394
123* CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94525177
124* PRDM14_20953172_ChIP-Seq_ESCs_Human0.94070147

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.81757454
2MP0003880_abnormal_central_pattern3.73398128
3MP0004270_analgesia3.61273905
4MP0003635_abnormal_synaptic_transmissio3.03879951
5MP0000778_abnormal_nervous_system2.83750788
6MP0005423_abnormal_somatic_nervous2.65645418
7MP0002063_abnormal_learning/memory/cond2.54939870
8MP0009780_abnormal_chondrocyte_physiolo2.48660054
9MP0001486_abnormal_startle_reflex2.47280860
10MP0009745_abnormal_behavioral_response2.43857315
11MP0002064_seizures2.39844422
12MP0002734_abnormal_mechanical_nocicepti2.36260877
13MP0002572_abnormal_emotion/affect_behav2.35854359
14MP0000569_abnormal_digit_pigmentation2.33401262
15MP0009046_muscle_twitch2.30324006
16MP0001968_abnormal_touch/_nociception2.10211412
17MP0005645_abnormal_hypothalamus_physiol2.09002233
18MP0002102_abnormal_ear_morphology2.02863764
19MP0002272_abnormal_nervous_system1.99324253
20MP0006292_abnormal_olfactory_placode1.90258708
21MP0001440_abnormal_grooming_behavior1.89789357
22MP0002733_abnormal_thermal_nociception1.86480417
23MP0002184_abnormal_innervation1.85861906
24MP0004924_abnormal_behavior1.84850569
25MP0005386_behavior/neurological_phenoty1.84850569
26MP0010234_abnormal_vibrissa_follicle1.84044316
27MP0002557_abnormal_social/conspecific_i1.82693038
28MP0002735_abnormal_chemical_nociception1.82609218
29MP0002909_abnormal_adrenal_gland1.81261463
30MP0005646_abnormal_pituitary_gland1.78790241
31MP0003787_abnormal_imprinting1.78474548
32MP0006276_abnormal_autonomic_nervous1.75797182
33MP0001529_abnormal_vocalization1.74566745
34MP0002067_abnormal_sensory_capabilities1.71054841
35MP0003329_amyloid_beta_deposits1.69788198
36MP0001984_abnormal_olfaction1.68151549
37MP0000955_abnormal_spinal_cord1.68130871
38MP0003122_maternal_imprinting1.63454839
39MP0003690_abnormal_glial_cell1.62335618
40MP0006072_abnormal_retinal_apoptosis1.60117234
41MP0004885_abnormal_endolymph1.58655391
42MP0000920_abnormal_myelination1.57093824
43MP0003937_abnormal_limbs/digits/tail_de1.56610445
44MP0001970_abnormal_pain_threshold1.55640493
45MP0001188_hyperpigmentation1.53366417
46MP0008789_abnormal_olfactory_epithelium1.52152638
47MP0004742_abnormal_vestibular_system1.52136202
48MP0004811_abnormal_neuron_physiology1.49974428
49MP0003634_abnormal_glial_cell1.49905547
50MP0002882_abnormal_neuron_morphology1.49852354
51MP0002638_abnormal_pupillary_reflex1.49503018
52MP0002938_white_spotting1.48967407
53MP0002736_abnormal_nociception_after1.47981161
54* MP0000631_abnormal_neuroendocrine_gland1.44029333
55MP0008877_abnormal_DNA_methylation1.42812228
56MP0000566_synostosis1.39679014
57MP0001501_abnormal_sleep_pattern1.38018257
58MP0003755_abnormal_palate_morphology1.35385470
59* MP0000049_abnormal_middle_ear1.34471339
60MP0003632_abnormal_nervous_system1.33829101
61* MP0002233_abnormal_nose_morphology1.32962425
62MP0001502_abnormal_circadian_rhythm1.32887342
63MP0005409_darkened_coat_color1.31747663
64* MP0002152_abnormal_brain_morphology1.29683245
65MP0002066_abnormal_motor_capabilities/c1.28415155
66MP0010386_abnormal_urinary_bladder1.25074608
67MP0005248_abnormal_Harderian_gland1.23367110
68MP0002229_neurodegeneration1.23331085
69MP0003283_abnormal_digestive_organ1.20852214
70MP0005551_abnormal_eye_electrophysiolog1.19850349
71MP0003938_abnormal_ear_development1.18821010
72MP0003385_abnormal_body_wall1.18256198
73* MP0003119_abnormal_digestive_system1.17320327
74MP0000537_abnormal_urethra_morphology1.16435906
75MP0002822_catalepsy1.16022777
76MP0008569_lethality_at_weaning1.15982916
77MP0004142_abnormal_muscle_tone1.15938514
78MP0005187_abnormal_penis_morphology1.13042671
79* MP0002697_abnormal_eye_size1.12597929
80MP0004858_abnormal_nervous_system1.12572672
81MP0003631_nervous_system_phenotype1.12565976
82MP0003633_abnormal_nervous_system1.11723967
83* MP0001293_anophthalmia1.11131627
84MP0002653_abnormal_ependyma_morphology1.10810874
85MP0001905_abnormal_dopamine_level1.07802205
86* MP0001286_abnormal_eye_development1.04887435
87MP0003183_abnormal_peptide_metabolism1.04464321
88* MP0003935_abnormal_craniofacial_develop1.04338394
89MP0003890_abnormal_embryonic-extraembry1.04331096
90MP0000462_abnormal_digestive_system1.02050063
91MP0003136_yellow_coat_color1.01907933
92MP0005253_abnormal_eye_physiology1.01278822
93MP0000026_abnormal_inner_ear1.00163871
94MP0003567_abnormal_fetal_cardiomyocyte0.99326237
95MP0003121_genomic_imprinting0.99042623
96MP0000534_abnormal_ureter_morphology0.96435096
97MP0002752_abnormal_somatic_nervous0.95951728
98MP0000604_amyloidosis0.95749175
99MP0004043_abnormal_pH_regulation0.95136089
100MP0001177_atelectasis0.92944893
101MP0002081_perinatal_lethality0.92645498
102* MP0003861_abnormal_nervous_system0.92330390
103MP0010678_abnormal_skin_adnexa0.91517576
104* MP0005391_vision/eye_phenotype0.90635897
105MP0002069_abnormal_eating/drinking_beha0.90630676
106MP0002090_abnormal_vision0.88476409
107MP0000013_abnormal_adipose_tissue0.83684677
108MP0001963_abnormal_hearing_physiology0.83274162
109MP0000427_abnormal_hair_cycle0.83193959
110MP0001485_abnormal_pinna_reflex0.82348342
111MP0005195_abnormal_posterior_eye0.80558134
112MP0002751_abnormal_autonomic_nervous0.80344694
113MP0000428_abnormal_craniofacial_morphol0.80309022
114MP0010030_abnormal_orbit_morphology0.80026830
115MP0003868_abnormal_feces_composition0.78302830
116MP0003195_calcinosis0.77729890
117MP0005367_renal/urinary_system_phenotyp0.77525620
118MP0000516_abnormal_urinary_system0.77525620
119MP0003942_abnormal_urinary_system0.77435818
120* MP0001299_abnormal_eye_distance/0.76875370
121* MP0002116_abnormal_craniofacial_bone0.76778896
122MP0004133_heterotaxia0.74448010
123MP0001944_abnormal_pancreas_morphology0.73966994
124MP0000383_abnormal_hair_follicle0.73207553
125MP0000647_abnormal_sebaceous_gland0.72103444
126MP0005379_endocrine/exocrine_gland_phen0.70561700
127MP0002693_abnormal_pancreas_physiology0.70351260
128MP0005499_abnormal_olfactory_system0.66255795
129MP0005394_taste/olfaction_phenotype0.66255795
130MP0002082_postnatal_lethality0.65581353
131MP0010770_preweaning_lethality0.65581353
132MP0001943_abnormal_respiration0.63113090

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the corticospinal tract (HP:0002492)4.10231190
2Neurofibrillary tangles (HP:0002185)3.96208425
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.76491768
4Degeneration of the lateral corticospinal tracts (HP:0002314)3.76491768
5Drooling (HP:0002307)3.62711478
6Excessive salivation (HP:0003781)3.62711478
7Cerebral inclusion bodies (HP:0100314)3.57150653
8Focal seizures (HP:0007359)3.41352360
9Termporal pattern (HP:0011008)3.35648272
10Insidious onset (HP:0003587)3.35648272
11Focal motor seizures (HP:0011153)3.31087583
12Akinesia (HP:0002304)3.29987316
13Supranuclear gaze palsy (HP:0000605)3.27542244
14Epileptic encephalopathy (HP:0200134)3.14429808
15Agitation (HP:0000713)3.07639598
16Hyperventilation (HP:0002883)3.07521592
17Myokymia (HP:0002411)3.04274044
18Spastic gait (HP:0002064)2.99826056
19Broad-based gait (HP:0002136)2.94866652
20Limb dystonia (HP:0002451)2.94736069
21Progressive cerebellar ataxia (HP:0002073)2.90746234
22Blue irides (HP:0000635)2.76958159
23Atonic seizures (HP:0010819)2.76469227
24Ankle clonus (HP:0011448)2.73842340
25EEG with generalized epileptiform discharges (HP:0011198)2.73584769
26Intestinal atresia (HP:0011100)2.71312159
27Febrile seizures (HP:0002373)2.70439726
28Hypsarrhythmia (HP:0002521)2.68466270
29Epileptiform EEG discharges (HP:0011182)2.66973371
30Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.58943516
31Protruding tongue (HP:0010808)2.56586152
32Visual hallucinations (HP:0002367)2.55646667
33True hermaphroditism (HP:0010459)2.55354986
34Lissencephaly (HP:0001339)2.55208785
35Absence seizures (HP:0002121)2.54686384
36Abnormality of salivation (HP:0100755)2.53836291
37Morphological abnormality of the pyramidal tract (HP:0002062)2.52219476
38Pancreatic cysts (HP:0001737)2.50938542
39Pancreatic fibrosis (HP:0100732)2.50268913
40Pheochromocytoma (HP:0002666)2.50233005
41Nephronophthisis (HP:0000090)2.49274201
42Urinary bladder sphincter dysfunction (HP:0002839)2.48372707
43Volvulus (HP:0002580)2.43894318
44Dialeptic seizures (HP:0011146)2.42904795
45Absent speech (HP:0001344)2.40122994
46Mutism (HP:0002300)2.40094456
47Molar tooth sign on MRI (HP:0002419)2.36781173
48Abnormality of midbrain morphology (HP:0002418)2.36781173
49Urinary urgency (HP:0000012)2.36313398
50Genital tract atresia (HP:0001827)2.35744669
51Vaginal atresia (HP:0000148)2.35109714
52Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.33921182
53Short 4th metacarpal (HP:0010044)2.33921182
54Macroorchidism (HP:0000053)2.33213871
55Action tremor (HP:0002345)2.31560874
56Anteriorly placed anus (HP:0001545)2.31264518
57Inappropriate behavior (HP:0000719)2.28826827
58Impaired vibration sensation in the lower limbs (HP:0002166)2.28352517
59Generalized tonic-clonic seizures (HP:0002069)2.28068804
60Chronic hepatic failure (HP:0100626)2.27682988
61Cortical dysplasia (HP:0002539)2.27290692
62Medial flaring of the eyebrow (HP:0010747)2.25332899
63Intention tremor (HP:0002080)2.22287019
64Papilledema (HP:0001085)2.21074005
65Aplasia/Hypoplasia of the sternum (HP:0006714)2.20445919
66Dysmetria (HP:0001310)2.20162181
67Hepatoblastoma (HP:0002884)2.20133027
68Renal hypoplasia (HP:0000089)2.17810056
69Aqueductal stenosis (HP:0002410)2.16669081
70Optic nerve hypoplasia (HP:0000609)2.16483634
71Truncal ataxia (HP:0002078)2.16335898
72Hemiparesis (HP:0001269)2.15817366
73Scanning speech (HP:0002168)2.15530461
74Lower limb muscle weakness (HP:0007340)2.15518653
75Megalencephaly (HP:0001355)2.15200211
76Midline defect of the nose (HP:0004122)2.15076369
77Widely spaced teeth (HP:0000687)2.13314830
78Pachygyria (HP:0001302)2.12712597
79Colon cancer (HP:0003003)2.12372852
80Cutaneous syndactyly (HP:0012725)2.11622891
81Polyphagia (HP:0002591)2.10868325
82Hypoglycemic seizures (HP:0002173)2.10151717
83Congenital primary aphakia (HP:0007707)2.09359950
84Amyotrophic lateral sclerosis (HP:0007354)2.09097620
85Abnormality of the renal medulla (HP:0100957)2.05975886
86Progressive inability to walk (HP:0002505)2.03360061
87Morphological abnormality of the middle ear (HP:0008609)2.03245338
88Vitreoretinal degeneration (HP:0000655)2.02526614
89Nephrogenic diabetes insipidus (HP:0009806)2.00824657
90Narrow forehead (HP:0000341)1.99721042
91Paraplegia (HP:0010550)1.99630095
92Anophthalmia (HP:0000528)1.99428541
93Exotropia (HP:0000577)1.98729885
94Thickened helices (HP:0000391)1.98238354
95Cupped ear (HP:0000378)1.96929188
96Gastroesophageal reflux (HP:0002020)1.96897793
97Generalized hypopigmentation of hair (HP:0011358)1.95416512
98Abnormal hair whorl (HP:0010721)1.95099191
99Postaxial hand polydactyly (HP:0001162)1.95034429
100Neuroendocrine neoplasm (HP:0100634)1.94358617
101Gait imbalance (HP:0002141)1.94227586
102Abnormality of the pubic bones (HP:0003172)1.93827479
103Neoplasm of the oral cavity (HP:0100649)1.93636971
104Micropenis (HP:0000054)1.91636915
105Hyperinsulinemic hypoglycemia (HP:0000825)1.90534524
106Abnormality of calcium-phosphate metabolism (HP:0100530)1.89896611
107Clonus (HP:0002169)1.88741917
108Open mouth (HP:0000194)1.87835156
109Aplasia/Hypoplasia of the brainstem (HP:0007362)1.87632298
110Hypoplasia of the brainstem (HP:0002365)1.87632298
111Absent eyebrow (HP:0002223)1.87461494
112Spastic paraplegia (HP:0001258)1.86277493
113Septo-optic dysplasia (HP:0100842)1.86146185
114Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.85536001
115Partial agenesis of the corpus callosum (HP:0001338)1.85300219
116Split foot (HP:0001839)1.84878245
117Bifid tongue (HP:0010297)1.84200834
118Oligodactyly (hands) (HP:0001180)1.83698017
119Papillary thyroid carcinoma (HP:0002895)1.83554274
120Patellar aplasia (HP:0006443)1.83098554
121Depression (HP:0000716)1.81720568
122Abnormality of the ischium (HP:0003174)1.81363999
123Parakeratosis (HP:0001036)1.81245945
124Dysdiadochokinesis (HP:0002075)1.80425443
125Symptomatic seizures (HP:0011145)1.79500703
126Neuronal loss in central nervous system (HP:0002529)1.79128923
127Anxiety (HP:0000739)1.78983947
128Poor coordination (HP:0002370)1.78706111
129Medulloblastoma (HP:0002885)1.78565701
130Labial hypoplasia (HP:0000066)1.78306788
131Genetic anticipation (HP:0003743)1.77373450
132Abnormality of the astrocytes (HP:0100707)1.77370171
133Astrocytoma (HP:0009592)1.77370171
134Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77217423
135Specific learning disability (HP:0001328)1.76905520
136Cutaneous finger syndactyly (HP:0010554)1.76668195
137Inability to walk (HP:0002540)1.76668140
138Preaxial hand polydactyly (HP:0001177)1.76482401
139Abnormality of the 4th metacarpal (HP:0010012)1.75716472
140Cystic liver disease (HP:0006706)1.75372923
141Scrotal hypoplasia (HP:0000046)1.74822420
142Hyperthyroidism (HP:0000836)1.73806618
143High anterior hairline (HP:0009890)1.73283039
144Gastrointestinal atresia (HP:0002589)1.72850917
145Myelomeningocele (HP:0002475)1.72812391
146Abnormality of the labia minora (HP:0012880)1.72511211
147Relative macrocephaly (HP:0004482)1.72504669
148Intellectual disability, moderate (HP:0002342)1.72448848
149Anencephaly (HP:0002323)1.72374433
150Postaxial foot polydactyly (HP:0001830)1.72343035
151Postural instability (HP:0002172)1.71991179
152Retinal dysplasia (HP:0007973)1.71138332
153Fair hair (HP:0002286)1.71018712
154Abnormal eating behavior (HP:0100738)1.70590673
155Diplopia (HP:0000651)1.70349619
156Abnormality of binocular vision (HP:0011514)1.70349619
157Preaxial foot polydactyly (HP:0001841)1.68427788
158Thyroid-stimulating hormone excess (HP:0002925)1.67978271
159Abnormality of the antihelix (HP:0009738)1.67516078
160Tubulointerstitial nephritis (HP:0001970)1.66434093
161Hypoplastic labia majora (HP:0000059)1.64912685
162Gaze-evoked nystagmus (HP:0000640)1.64790880
163Occipital encephalocele (HP:0002085)1.64477215
164Aplasia/Hypoplasia of the patella (HP:0006498)1.64226170

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.44737540
2CASK3.21954198
3NTRK32.84515922
4MAP3K92.69156920
5TRIM282.36969343
6MAP3K42.36709398
7MAPK132.21994022
8NTRK22.12608702
9WNK32.11730649
10STK392.11608475
11CSNK1G22.02198273
12MAP3K21.78978755
13CSNK1G31.77239811
14PNCK1.73845109
15MKNK21.73511095
16OXSR11.72823399
17BCR1.72415315
18NTRK11.68731391
19UHMK11.67591515
20INSRR1.66968411
21MAP4K21.65568297
22PAK61.63277464
23EPHA41.55656857
24KSR11.55571329
25PKN11.53770578
26CSNK1G11.51619857
27CSNK1A1L1.51530460
28FGFR21.48788167
29MINK11.44193837
30FRK1.43732318
31PAK31.43730003
32MAP2K71.40118394
33EPHA31.35877859
34DYRK21.35756360
35MKNK11.31287584
36TNIK1.28014227
37CDK51.24075104
38ERBB31.19906659
39PHKG21.16438006
40PHKG11.16438006
41KSR21.15345286
42PRKD31.14217269
43CAMK1G1.13117159
44WNK11.10419972
45SCYL21.09746980
46WNK41.05965663
47MAP2K41.05854228
48SGK2231.01565341
49SGK4941.01565341
50DAPK21.00327589
51SIK20.99018563
52PINK10.97680784
53LATS10.96190425
54DYRK30.95892779
55CAMK2B0.95556895
56MARK20.91037837
57CAMK2A0.89737680
58ACVR1B0.88438581
59FGR0.87978135
60STK110.87772888
61ERBB40.85733465
62DYRK1A0.85185940
63ADRBK20.84555351
64SRPK10.83989460
65PRPF4B0.83916496
66PLK20.81730398
67BMPR1B0.81083427
68NUAK10.81000716
69AKT30.78544510
70PRKCE0.77872932
71RET0.76433094
72CCNB10.75477006
73SGK10.75214840
74STK38L0.72428527
75PRKCH0.71958822
76CDK30.71136799
77LIMK10.70723977
78EPHB20.70433666
79SGK20.70413080
80PLK40.69459501
81CSNK1D0.67071073
82CDK190.65861684
83CAMKK20.65538006
84FER0.65303542
85YES10.63564273
86BRD40.63547539
87PRKCG0.62899928
88ICK0.62872253
89CAMK2D0.61158761
90HIPK20.60247402
91FGFR10.57623572
92GRK50.57172576
93PRKCZ0.56913344
94WEE10.56754989
95CDC42BPA0.56160627
96TYRO30.54748853
97ERBB20.54489491
98CDK140.54414819
99CAMK1D0.53643380
100FYN0.53418622
101RPS6KA40.53164861
102TAF10.51769845
103PRKG10.50786658
104CDK180.50533218
105SGK30.50436537
106CDK150.50200786
107GRK10.50158986
108RPS6KA30.49586368
109GSK3A0.48058364
110ALK0.48032355
111CAMK2G0.47988811
112MAP3K130.47477418
113MET0.45041141
114BRSK20.44554711
115MAPK100.44450592
116PLK30.44325392
117NEK60.44134679
118ADRBK10.43651349
119CAMK40.43156003
120PRKCB0.40774050
121CDC70.40558180
122CSNK1E0.39452738
123ATM0.39392288
124ROCK20.39034934
125PDGFRB0.37282294
126RPS6KA20.37058492
127GSK3B0.36808525
128VRK10.36684564
129PRKACB0.36662831
130CDK11A0.35609816
131TGFBR10.35323365
132ZAK0.34598944
133PRKDC0.33469471
134MAPK90.33145784
135CSNK1A10.33049351
136DYRK1B0.32498392
137PRKAA10.31195558
138NEK20.30654689

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.93328481
2GABAergic synapse_Homo sapiens_hsa047272.35628867
3Synaptic vesicle cycle_Homo sapiens_hsa047212.33430168
4Steroid biosynthesis_Homo sapiens_hsa001002.18846498
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.11395575
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.08901149
7Morphine addiction_Homo sapiens_hsa050322.08306247
8Glutamatergic synapse_Homo sapiens_hsa047242.02926463
9Insulin secretion_Homo sapiens_hsa049112.02826035
10Circadian entrainment_Homo sapiens_hsa047131.98401291
11Cocaine addiction_Homo sapiens_hsa050301.94025763
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.90460228
13Dopaminergic synapse_Homo sapiens_hsa047281.88900758
14Axon guidance_Homo sapiens_hsa043601.85294597
15Long-term potentiation_Homo sapiens_hsa047201.83644941
16Serotonergic synapse_Homo sapiens_hsa047261.82725083
17Amphetamine addiction_Homo sapiens_hsa050311.82130073
18Nitrogen metabolism_Homo sapiens_hsa009101.81624909
19Basal cell carcinoma_Homo sapiens_hsa052171.79234547
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.73599864
21Taste transduction_Homo sapiens_hsa047421.66876410
22Type II diabetes mellitus_Homo sapiens_hsa049301.62139660
23Cholinergic synapse_Homo sapiens_hsa047251.61618354
24Long-term depression_Homo sapiens_hsa047301.61198398
25Olfactory transduction_Homo sapiens_hsa047401.54790218
26Renin secretion_Homo sapiens_hsa049241.49958688
27Hippo signaling pathway_Homo sapiens_hsa043901.48401975
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.47696132
29Protein export_Homo sapiens_hsa030601.38353579
30Dorso-ventral axis formation_Homo sapiens_hsa043201.38055567
31Basal transcription factors_Homo sapiens_hsa030221.36021367
32Salivary secretion_Homo sapiens_hsa049701.34971707
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.34175354
34Collecting duct acid secretion_Homo sapiens_hsa049661.29016022
35Gastric acid secretion_Homo sapiens_hsa049711.28699055
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27803867
37Non-homologous end-joining_Homo sapiens_hsa034501.25712875
38Butanoate metabolism_Homo sapiens_hsa006501.24183122
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.21529860
40Vibrio cholerae infection_Homo sapiens_hsa051101.18916532
41ErbB signaling pathway_Homo sapiens_hsa040121.17364356
42Gap junction_Homo sapiens_hsa045401.16772643
43Circadian rhythm_Homo sapiens_hsa047101.13226897
44Fanconi anemia pathway_Homo sapiens_hsa034601.11990873
45GnRH signaling pathway_Homo sapiens_hsa049121.10716072
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.10287747
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09510908
48Sulfur metabolism_Homo sapiens_hsa009201.08708264
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08257575
50Estrogen signaling pathway_Homo sapiens_hsa049151.05600707
51RNA degradation_Homo sapiens_hsa030181.05564985
52Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03019985
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02723875
54Renal cell carcinoma_Homo sapiens_hsa052110.97223151
55Ether lipid metabolism_Homo sapiens_hsa005650.96718757
56Melanogenesis_Homo sapiens_hsa049160.95249153
57Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93390269
58Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91594847
59Oocyte meiosis_Homo sapiens_hsa041140.90882723
60Oxytocin signaling pathway_Homo sapiens_hsa049210.89822948
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.88219202
62Alcoholism_Homo sapiens_hsa050340.85569576
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85270230
64Propanoate metabolism_Homo sapiens_hsa006400.84976105
65Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.84527280
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84282565
67Phototransduction_Homo sapiens_hsa047440.84091004
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83807335
69mRNA surveillance pathway_Homo sapiens_hsa030150.83647876
70Calcium signaling pathway_Homo sapiens_hsa040200.83144838
71cAMP signaling pathway_Homo sapiens_hsa040240.83065390
72Glioma_Homo sapiens_hsa052140.81894072
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80321539
74TGF-beta signaling pathway_Homo sapiens_hsa043500.79292914
75Endometrial cancer_Homo sapiens_hsa052130.78699778
76Adherens junction_Homo sapiens_hsa045200.77487630
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77011827
78Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74546185
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74337181
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73689397
81Pancreatic secretion_Homo sapiens_hsa049720.73639829
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71946508
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.69113926
84Thyroid hormone synthesis_Homo sapiens_hsa049180.68991398
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67466289
86* Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66846547
87Cardiac muscle contraction_Homo sapiens_hsa042600.65948419
88Bile secretion_Homo sapiens_hsa049760.65534113
89Choline metabolism in cancer_Homo sapiens_hsa052310.64981234
90Prion diseases_Homo sapiens_hsa050200.64292186
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.63227907
92Regulation of autophagy_Homo sapiens_hsa041400.62617226
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62474226
94Linoleic acid metabolism_Homo sapiens_hsa005910.62050698
95Inositol phosphate metabolism_Homo sapiens_hsa005620.60880810
96Ras signaling pathway_Homo sapiens_hsa040140.60285693
97Sphingolipid metabolism_Homo sapiens_hsa006000.59845848
98Ovarian steroidogenesis_Homo sapiens_hsa049130.58427296
99Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58377283
100Selenocompound metabolism_Homo sapiens_hsa004500.57177923
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57057891
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.55876734
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53366143
104Wnt signaling pathway_Homo sapiens_hsa043100.52285769
105Type I diabetes mellitus_Homo sapiens_hsa049400.51911671
106MAPK signaling pathway_Homo sapiens_hsa040100.51319757
107Melanoma_Homo sapiens_hsa052180.49238802
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49203601
109Glucagon signaling pathway_Homo sapiens_hsa049220.48488759
110Fatty acid elongation_Homo sapiens_hsa000620.47873981
111Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.46988606
112Dilated cardiomyopathy_Homo sapiens_hsa054140.46625147
113MicroRNAs in cancer_Homo sapiens_hsa052060.46379318
114Tight junction_Homo sapiens_hsa045300.44852608
115RNA transport_Homo sapiens_hsa030130.44438301
116Hedgehog signaling pathway_Homo sapiens_hsa043400.43530772
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41345674
118Colorectal cancer_Homo sapiens_hsa052100.40990048
119Protein digestion and absorption_Homo sapiens_hsa049740.40780332
120mTOR signaling pathway_Homo sapiens_hsa041500.38853297
121Fatty acid biosynthesis_Homo sapiens_hsa000610.38196030
122Insulin signaling pathway_Homo sapiens_hsa049100.37111828
123AMPK signaling pathway_Homo sapiens_hsa041520.36576983
124Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36481992
125Cell cycle_Homo sapiens_hsa041100.35702595
126Lysine degradation_Homo sapiens_hsa003100.34133630
127Endocytosis_Homo sapiens_hsa041440.33475625
128ABC transporters_Homo sapiens_hsa020100.32792544
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.32393507
130Rap1 signaling pathway_Homo sapiens_hsa040150.32241211
131Phagosome_Homo sapiens_hsa041450.32215988
132Mineral absorption_Homo sapiens_hsa049780.30997548
133Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30352649
134Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29008427
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.28770530

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