PGBD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The piggyBac family of proteins, found in diverse animals, are transposases related to the transposase of the canonical piggyBac transposon from the moth, Trichoplusia ni. This family also includes genes in several genomes, including human, that appear to have been derived from the piggyBac transposons. This gene belongs to the subfamily of piggyBac transposable element derived (PGBD) genes. The PGBD proteins appear to be novel, with no obvious relationship to other transposases, or other known protein families. The exact function of this gene is not known. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neural tube formation (GO:0001841)4.94070925
2indole-containing compound catabolic process (GO:0042436)4.86424223
3indolalkylamine catabolic process (GO:0046218)4.86424223
4tryptophan catabolic process (GO:0006569)4.86424223
5indolalkylamine metabolic process (GO:0006586)4.77891557
6detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.66695626
7signal peptide processing (GO:0006465)4.60640913
8kynurenine metabolic process (GO:0070189)4.48477691
9tryptophan metabolic process (GO:0006568)4.32870205
10DNA double-strand break processing (GO:0000729)4.20682687
11photoreceptor cell maintenance (GO:0045494)4.14100815
12protein prenylation (GO:0018342)3.98346147
13prenylation (GO:0097354)3.98346147
14behavioral response to ethanol (GO:0048149)3.77514385
15tachykinin receptor signaling pathway (GO:0007217)3.73792981
16cilium or flagellum-dependent cell motility (GO:0001539)3.67477505
17monoubiquitinated protein deubiquitination (GO:0035520)3.62440654
18double-strand break repair via homologous recombination (GO:0000724)3.59587034
19L-fucose metabolic process (GO:0042354)3.57344731
20L-fucose catabolic process (GO:0042355)3.57344731
21fucose catabolic process (GO:0019317)3.57344731
22positive regulation of developmental pigmentation (GO:0048087)3.57326068
23recombinational repair (GO:0000725)3.56841780
24replication fork processing (GO:0031297)3.47977634
25regulation of hippo signaling (GO:0035330)3.47287772
26detection of light stimulus involved in sensory perception (GO:0050962)3.45580739
27detection of light stimulus involved in visual perception (GO:0050908)3.45580739
28reflex (GO:0060004)3.36244403
29retinal cone cell development (GO:0046549)3.32862348
30auditory receptor cell stereocilium organization (GO:0060088)3.21932148
31protein K11-linked deubiquitination (GO:0035871)3.20091133
32L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.18217210
33cellular biogenic amine catabolic process (GO:0042402)3.18007785
34amine catabolic process (GO:0009310)3.18007785
35reciprocal meiotic recombination (GO:0007131)3.14399383
36reciprocal DNA recombination (GO:0035825)3.14399383
37negative regulation of DNA-dependent DNA replication (GO:2000104)3.12211351
38regulation of pigment cell differentiation (GO:0050932)3.12005445
39behavioral response to nicotine (GO:0035095)3.09977689
40indole-containing compound metabolic process (GO:0042430)3.09878836
41response to pheromone (GO:0019236)3.02789688
42regulation of meiosis I (GO:0060631)3.00188641
43microtubule anchoring (GO:0034453)2.97224082
44sphingoid metabolic process (GO:0046519)2.96189320
45RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.96131881
46establishment of protein localization to Golgi (GO:0072600)2.95582963
47cellular ketone body metabolic process (GO:0046950)2.91672470
48benzene-containing compound metabolic process (GO:0042537)2.90565431
49dopamine transport (GO:0015872)2.89459641
50detection of mechanical stimulus involved in sensory perception (GO:0050974)2.88902231
51methionine biosynthetic process (GO:0009086)2.87655516
52histone H3-K9 methylation (GO:0051567)2.87579249
53righting reflex (GO:0060013)2.84519427
54regulation of sarcomere organization (GO:0060297)2.82356116
55centriole replication (GO:0007099)2.81538554
56cellular response to sterol (GO:0036315)2.81143691
57UDP-N-acetylglucosamine metabolic process (GO:0006047)2.81129933
58ketone body metabolic process (GO:1902224)2.79766521
59piRNA metabolic process (GO:0034587)2.78591665
60aromatic amino acid family catabolic process (GO:0009074)2.77276764
61aromatic amino acid family metabolic process (GO:0009072)2.74673510
62negative regulation of translation, ncRNA-mediated (GO:0040033)2.74071710
63regulation of translation, ncRNA-mediated (GO:0045974)2.74071710
64negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.74071710
65maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.73961719
66epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.73782482
67DNA methylation involved in gamete generation (GO:0043046)2.71840908
68negative regulation of calcium ion transport into cytosol (GO:0010523)2.70301928
69DNA deamination (GO:0045006)2.69311324
70oxidative demethylation (GO:0070989)2.68989508
71regulation of posttranscriptional gene silencing (GO:0060147)2.67130246
72regulation of gene silencing by miRNA (GO:0060964)2.67130246
73regulation of gene silencing by RNA (GO:0060966)2.67130246
74NAD biosynthetic process (GO:0009435)2.66896721
75protein K48-linked deubiquitination (GO:0071108)2.66834908
76amino acid salvage (GO:0043102)2.65493015
77L-methionine salvage (GO:0071267)2.65493015
78L-methionine biosynthetic process (GO:0071265)2.65493015
79negative regulation of cytosolic calcium ion concentration (GO:0051481)2.64899776
80regulation of nuclear cell cycle DNA replication (GO:0033262)2.61968367
81cilium organization (GO:0044782)2.60569972
82central nervous system neuron axonogenesis (GO:0021955)2.58337278
83regulation of establishment of cell polarity (GO:2000114)2.57716723
84cilium morphogenesis (GO:0060271)2.57269195
85mannosylation (GO:0097502)2.56690099
86protein K63-linked deubiquitination (GO:0070536)2.54398994
87gene silencing by RNA (GO:0031047)2.53366554
88cilium assembly (GO:0042384)2.53038709
89regulation of cilium movement (GO:0003352)2.51035961
90regulation of protein glycosylation (GO:0060049)2.50760751
91axoneme assembly (GO:0035082)2.50697994
92snRNA transcription (GO:0009301)2.50099540
93protein localization to cilium (GO:0061512)2.49709285
94inner ear receptor stereocilium organization (GO:0060122)2.49520334
95somatic diversification of immune receptors via somatic mutation (GO:0002566)2.48484300
96somatic hypermutation of immunoglobulin genes (GO:0016446)2.48484300
97cellular response to ethanol (GO:0071361)2.48175954
98methionine metabolic process (GO:0006555)2.45338504
99respiratory chain complex IV assembly (GO:0008535)2.44845164
100synapsis (GO:0007129)2.44212643

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.25680543
2IGF1R_20145208_ChIP-Seq_DFB_Human3.18746333
3VDR_22108803_ChIP-Seq_LS180_Human3.14113854
4ZNF274_21170338_ChIP-Seq_K562_Hela3.11080987
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.86946261
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.79651202
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.74108202
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.66183061
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.59585721
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.59265366
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.39431152
12TAF15_26573619_Chip-Seq_HEK293_Human2.36433190
13P300_19829295_ChIP-Seq_ESCs_Human2.23947357
14EWS_26573619_Chip-Seq_HEK293_Human2.22678806
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20580916
16AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.19806821
17FUS_26573619_Chip-Seq_HEK293_Human2.08687741
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.04523335
19SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.04017075
20ER_23166858_ChIP-Seq_MCF-7_Human1.98786558
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.86852881
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85032373
23STAT3_23295773_ChIP-Seq_U87_Human1.83210396
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.74477818
25UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.73192053
26SMAD4_21799915_ChIP-Seq_A2780_Human1.71734866
27BCAT_22108803_ChIP-Seq_LS180_Human1.69289922
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.67413746
29EZH2_27294783_Chip-Seq_NPCs_Mouse1.66495072
30TCF4_23295773_ChIP-Seq_U87_Human1.64917009
31CBP_20019798_ChIP-Seq_JUKART_Human1.64397642
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.64397642
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61325052
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55198995
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.54864653
36AR_25329375_ChIP-Seq_VCAP_Human1.49731734
37IRF1_19129219_ChIP-ChIP_H3396_Human1.48999887
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.47513746
39SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47284580
40NR3C1_21868756_ChIP-Seq_MCF10A_Human1.46819837
41POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.46681939
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46681939
43TCF4_22108803_ChIP-Seq_LS180_Human1.43878774
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43275754
45SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41872292
46CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.41322324
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.40842757
48TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.40316648
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38334953
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36151052
51NANOG_18555785_Chip-Seq_ESCs_Mouse1.36047098
52NANOG_19829295_ChIP-Seq_ESCs_Human1.35284765
53SOX2_19829295_ChIP-Seq_ESCs_Human1.35284765
54CRX_20693478_ChIP-Seq_RETINA_Mouse1.35180453
55NOTCH1_21737748_ChIP-Seq_TLL_Human1.34704304
56KLF5_20875108_ChIP-Seq_MESCs_Mouse1.33977562
57PRDM14_20953172_ChIP-Seq_ESCs_Human1.33373822
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32580480
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29662271
60EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29069835
61CDX2_22108803_ChIP-Seq_LS180_Human1.28625643
62AR_21572438_ChIP-Seq_LNCaP_Human1.27650315
63TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26053142
64RUNX2_22187159_ChIP-Seq_PCA_Human1.25994884
65EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25792921
66* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25085664
67P53_22387025_ChIP-Seq_ESCs_Mouse1.24920999
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24899622
69FLI1_21867929_ChIP-Seq_TH2_Mouse1.23711956
70TP53_22573176_ChIP-Seq_HFKS_Human1.23134163
71E2F1_18555785_Chip-Seq_ESCs_Mouse1.21021912
72OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20277111
73SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18605571
74FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18434648
75P300_18555785_Chip-Seq_ESCs_Mouse1.17488482
76SMAD4_21741376_ChIP-Seq_EPCs_Human1.17303431
77STAT3_18555785_Chip-Seq_ESCs_Mouse1.16188823
78SMAD_19615063_ChIP-ChIP_OVARY_Human1.15957494
79SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.15451409
80ELK1_19687146_ChIP-ChIP_HELA_Human1.15243657
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14693350
82CMYC_18555785_Chip-Seq_ESCs_Mouse1.13889052
83CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09753311
84E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09580963
85EGR1_23403033_ChIP-Seq_LIVER_Mouse1.08415216
86RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06915013
87FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06349695
88FOXA1_25329375_ChIP-Seq_VCAP_Human1.06349695
89KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.04722353
90E2F4_17652178_ChIP-ChIP_JURKAT_Human1.03408089
91KDM2B_26808549_Chip-Seq_REH_Human1.02615683
92FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02370716
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01236026
94TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00798668
95OCT4_18555785_Chip-Seq_ESCs_Mouse1.00411416
96TP53_16413492_ChIP-PET_HCT116_Human0.99911034
97EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98912943
98SOX2_18555785_Chip-Seq_ESCs_Mouse0.98790510
99ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.96981117
100PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96030043

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.67707500
2MP0000569_abnormal_digit_pigmentation3.48378912
3MP0003195_calcinosis3.22103989
4MP0008877_abnormal_DNA_methylation2.87010566
5MP0001501_abnormal_sleep_pattern2.62346421
6MP0005551_abnormal_eye_electrophysiolog2.56401862
7MP0000372_irregular_coat_pigmentation2.56158633
8MP0004147_increased_porphyrin_level2.49406077
9MP0004043_abnormal_pH_regulation2.44035068
10MP0002102_abnormal_ear_morphology2.30639607
11MP0009697_abnormal_copulation2.25608279
12MP0003787_abnormal_imprinting2.14358294
13MP0010094_abnormal_chromosome_stability2.09785059
14MP0008058_abnormal_DNA_repair2.07612541
15MP0009046_muscle_twitch2.04253575
16MP0003646_muscle_fatigue2.00946495
17MP0002736_abnormal_nociception_after1.94886259
18MP0005253_abnormal_eye_physiology1.92239287
19MP0001968_abnormal_touch/_nociception1.91885182
20MP0000427_abnormal_hair_cycle1.87920597
21MP0003718_maternal_effect1.79815147
22MP0008872_abnormal_physiological_respon1.77634351
23MP0005646_abnormal_pituitary_gland1.73092624
24MP0003950_abnormal_plasma_membrane1.72745356
25MP0003136_yellow_coat_color1.72202071
26MP0005171_absent_coat_pigmentation1.62016064
27MP0006054_spinal_hemorrhage1.60440902
28MP0005645_abnormal_hypothalamus_physiol1.52386359
29MP0005075_abnormal_melanosome_morpholog1.46800367
30MP0001485_abnormal_pinna_reflex1.41147110
31MP0006072_abnormal_retinal_apoptosis1.39414230
32MP0000383_abnormal_hair_follicle1.38111815
33MP0005174_abnormal_tail_pigmentation1.37990611
34MP0005310_abnormal_salivary_gland1.37461214
35MP0009745_abnormal_behavioral_response1.35353547
36MP0001764_abnormal_homeostasis1.31154473
37MP0002837_dystrophic_cardiac_calcinosis1.29462476
38MP0005085_abnormal_gallbladder_physiolo1.29321302
39MP0002938_white_spotting1.28426494
40MP0001984_abnormal_olfaction1.27518077
41MP0003252_abnormal_bile_duct1.26489705
42MP0002735_abnormal_chemical_nociception1.24591938
43MP0001486_abnormal_startle_reflex1.24277558
44MP0006276_abnormal_autonomic_nervous1.22087696
45MP0005167_abnormal_blood-brain_barrier1.21245212
46MP0010386_abnormal_urinary_bladder1.19719158
47MP0002138_abnormal_hepatobiliary_system1.18799998
48MP0002095_abnormal_skin_pigmentation1.16880617
49MP0005395_other_phenotype1.14632083
50MP0002638_abnormal_pupillary_reflex1.12775662
51MP0000371_diluted_coat_color1.12261136
52MP0000631_abnormal_neuroendocrine_gland1.11874572
53MP0005410_abnormal_fertilization1.11864270
54MP0003890_abnormal_embryonic-extraembry1.11692648
55MP0002254_reproductive_system_inflammat1.09820900
56MP0003045_fibrosis1.07431775
57MP0005386_behavior/neurological_phenoty1.07132430
58MP0004924_abnormal_behavior1.07132430
59MP0003943_abnormal_hepatobiliary_system1.07101673
60MP0002272_abnormal_nervous_system1.02374437
61MP0000015_abnormal_ear_pigmentation0.99378235
62MP0002168_other_aberrant_phenotype0.98566603
63MP0003698_abnormal_male_reproductive0.98470507
64MP0002751_abnormal_autonomic_nervous0.97427580
65MP0002229_neurodegeneration0.96308891
66MP0001929_abnormal_gametogenesis0.94530475
67MP0001529_abnormal_vocalization0.94461395
68MP0002090_abnormal_vision0.94261384
69MP0004142_abnormal_muscle_tone0.93991228
70MP0003786_premature_aging0.93865501
71MP0002067_abnormal_sensory_capabilities0.93240233
72MP0004215_abnormal_myocardial_fiber0.92983605
73MP0001324_abnormal_eye_pigmentation0.87940684
74MP0002653_abnormal_ependyma_morphology0.87735344
75MP0002876_abnormal_thyroid_physiology0.87280509
76MP0001986_abnormal_taste_sensitivity0.87162953
77MP0005195_abnormal_posterior_eye0.86109792
78MP0003121_genomic_imprinting0.85304224
79MP0009764_decreased_sensitivity_to0.83933162
80MP0005266_abnormal_metabolism0.83039069
81MP0006292_abnormal_olfactory_placode0.81839489
82MP0008789_abnormal_olfactory_epithelium0.81538359
83MP0005647_abnormal_sex_gland0.81429336
84MP0002928_abnormal_bile_duct0.80910265
85MP0004145_abnormal_muscle_electrophysio0.78227320
86MP0000653_abnormal_sex_gland0.77294480
87MP0008875_abnormal_xenobiotic_pharmacok0.75074447
88MP0003880_abnormal_central_pattern0.74847631
89MP0002210_abnormal_sex_determination0.74409573
90MP0003656_abnormal_erythrocyte_physiolo0.74238311
91MP0002572_abnormal_emotion/affect_behav0.73966042
92MP0005389_reproductive_system_phenotype0.73574690
93MP0000230_abnormal_systemic_arterial0.72671404
94MP0003633_abnormal_nervous_system0.72521822
95MP0000538_abnormal_urinary_bladder0.72155537
96MP0008995_early_reproductive_senescence0.72145514
97MP0010678_abnormal_skin_adnexa0.70156832
98MP0000647_abnormal_sebaceous_gland0.68079343
99MP0002752_abnormal_somatic_nervous0.66309220
100MP0004742_abnormal_vestibular_system0.65753303

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.22080968
2Gaze-evoked nystagmus (HP:0000640)4.02658262
3Hyperventilation (HP:0002883)3.98249490
4Pancreatic fibrosis (HP:0100732)3.60814439
5True hermaphroditism (HP:0010459)3.56854144
6Abnormality of the renal cortex (HP:0011035)3.26723041
7Genetic anticipation (HP:0003743)3.23202534
8Nephronophthisis (HP:0000090)3.16421437
9Abnormality of the renal medulla (HP:0100957)3.12296562
10Congenital stationary night blindness (HP:0007642)3.11028522
11Abnormality of midbrain morphology (HP:0002418)3.09494124
12Molar tooth sign on MRI (HP:0002419)3.09494124
13Attenuation of retinal blood vessels (HP:0007843)3.09067265
14Medial flaring of the eyebrow (HP:0010747)2.86060385
15Progressive cerebellar ataxia (HP:0002073)2.78935022
16Chronic hepatic failure (HP:0100626)2.74907159
17Fair hair (HP:0002286)2.68362819
18Progressive inability to walk (HP:0002505)2.63260631
19Abolished electroretinogram (ERG) (HP:0000550)2.60809686
20Chromosomal breakage induced by crosslinking agents (HP:0003221)2.54265442
21Cystic liver disease (HP:0006706)2.53134115
22Renal cortical cysts (HP:0000803)2.52073058
23Chromsome breakage (HP:0040012)2.51170270
24Absent speech (HP:0001344)2.48918405
25Central scotoma (HP:0000603)2.45535208
26Volvulus (HP:0002580)2.44765488
27Febrile seizures (HP:0002373)2.43718185
28Aplasia/Hypoplasia of the uvula (HP:0010293)2.43659309
29Hypothermia (HP:0002045)2.43194011
30Congenital sensorineural hearing impairment (HP:0008527)2.42830652
31Protruding tongue (HP:0010808)2.41318879
32Bony spicule pigmentary retinopathy (HP:0007737)2.39971974
33Inability to walk (HP:0002540)2.38405370
34Abnormality of the labia minora (HP:0012880)2.35582130
35Aplasia/Hypoplasia of the tibia (HP:0005772)2.33322909
36Dialeptic seizures (HP:0011146)2.32978825
37Abnormality of chromosome stability (HP:0003220)2.32401505
38Intestinal atresia (HP:0011100)2.30599438
39Stomach cancer (HP:0012126)2.27385330
40Clumsiness (HP:0002312)2.27326352
41Congenital primary aphakia (HP:0007707)2.25526139
42Type II lissencephaly (HP:0007260)2.24796799
43Hyperalaninemia (HP:0003348)2.22997650
44Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22997650
45Abnormality of alanine metabolism (HP:0010916)2.22997650
46Gait imbalance (HP:0002141)2.21705532
47Congenital hepatic fibrosis (HP:0002612)2.20017722
48Aplasia/Hypoplasia of the tongue (HP:0010295)2.19881570
49Widely spaced teeth (HP:0000687)2.19661513
50Cerebellar dysplasia (HP:0007033)2.17965159
51Methylmalonic aciduria (HP:0012120)2.16798653
52Small hand (HP:0200055)2.15773989
53Thyroiditis (HP:0100646)2.12706985
54Clubbing of toes (HP:0100760)2.11723978
55Facial diplegia (HP:0001349)2.11189069
56Abnormal biliary tract physiology (HP:0012439)2.11153843
57Bile duct proliferation (HP:0001408)2.11153843
58Constricted visual fields (HP:0001133)2.08691683
59Astigmatism (HP:0000483)2.08648086
60Increased neuronal autofluorescent lipopigment (HP:0002074)2.06345491
61Nephrogenic diabetes insipidus (HP:0009806)2.04435351
62Keratoconus (HP:0000563)2.04390126
63Increased corneal curvature (HP:0100692)2.04390126
64Generalized hypopigmentation of hair (HP:0011358)2.03874660
65Abnormality of the ileum (HP:0001549)2.03697136
66Abnormality of macular pigmentation (HP:0008002)2.01973001
67Sloping forehead (HP:0000340)2.00672715
68Broad-based gait (HP:0002136)1.99512557
69Abnormality of the pons (HP:0007361)1.98000792
70Tubular atrophy (HP:0000092)1.97263198
71Furrowed tongue (HP:0000221)1.96304679
72Polydipsia (HP:0001959)1.95449771
73Abnormal drinking behavior (HP:0030082)1.95449771
74Thyroid-stimulating hormone excess (HP:0002925)1.94492536
75Focal seizures (HP:0007359)1.94211707
76Meckel diverticulum (HP:0002245)1.93622597
77Hypoplasia of the pons (HP:0012110)1.92872312
78Birth length less than 3rd percentile (HP:0003561)1.92240861
79Genital tract atresia (HP:0001827)1.92043039
80Colon cancer (HP:0003003)1.91512021
81Tubulointerstitial nephritis (HP:0001970)1.91135586
82Sclerocornea (HP:0000647)1.91129867
83Methylmalonic acidemia (HP:0002912)1.89970499
84Decreased electroretinogram (ERG) amplitude (HP:0000654)1.89459716
85Focal motor seizures (HP:0011153)1.88927344
86Severe visual impairment (HP:0001141)1.88273563
87Scotoma (HP:0000575)1.88195646
88Postaxial foot polydactyly (HP:0001830)1.85789614
89Pendular nystagmus (HP:0012043)1.85428908
90Abnormal rod and cone electroretinograms (HP:0008323)1.82651815
91Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.81748291
92Vaginal atresia (HP:0000148)1.81488001
93Absence seizures (HP:0002121)1.80712362
94Decreased central vision (HP:0007663)1.80030642
95Large for gestational age (HP:0001520)1.79392721
96Abnormality of B cell number (HP:0010975)1.77552439
97Poor coordination (HP:0002370)1.76423308
98Oculomotor apraxia (HP:0000657)1.74639361
99Male pseudohermaphroditism (HP:0000037)1.73289349
100Abnormal ciliary motility (HP:0012262)1.71535830

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.52922473
2ACVR1B3.96769461
3NUAK13.07386636
4BMPR1B3.02172573
5LATS12.61912217
6MAP4K22.48018466
7WNK32.23867855
8ADRBK22.14640921
9MKNK21.83932548
10ZAK1.80800083
11TAOK31.80739390
12INSRR1.78711998
13STK38L1.74846240
14EIF2AK31.74012726
15MAPK131.64731841
16GRK11.44866686
17TRIM281.44315254
18AKT31.44116073
19OXSR11.39042098
20STK31.29233017
21PIK3CG1.29134192
22PINK11.26882845
23MAP3K41.25963671
24BRSK21.25428664
25MST41.20703721
26TNIK1.18465609
27CASK1.16282259
28STK391.14711527
29TGFBR11.10816442
30PLK41.10357486
31NTRK31.09399418
32TNK21.07820452
33MKNK11.04946312
34ERBB31.03200404
35BCR0.99176904
36PLK20.97058641
37IRAK10.96856158
38PTK2B0.91969880
39TEC0.90752834
40NLK0.90383955
41ADRBK10.90121264
42CDC70.84622082
43WEE10.80179854
44PBK0.80040252
45PLK30.76356694
46FER0.73659495
47TXK0.73659028
48PRKCE0.73468633
49EIF2AK10.70977808
50CSNK1G10.70182144
51MELK0.69369706
52CSNK1A1L0.62951323
53PAK30.62367970
54BRD40.61179377
55VRK10.60383843
56BUB10.56564676
57CSNK1G20.54672102
58CDK190.54461826
59DAPK20.53118288
60PLK10.51216432
61NEK10.50699149
62CAMKK20.50369576
63CSNK1G30.49331591
64PRKCG0.49217378
65TLK10.48957704
66PDK20.48494982
67PRKAA20.46018352
68FGFR20.44574705
69CHEK20.44332937
70ATM0.43547840
71CDK30.43233039
72EIF2AK20.43117586
73ATR0.42824693
74BMPR20.41076803
75IKBKB0.40053806
76MARK30.39916350
77CSNK1D0.39789983
78CAMK2A0.39758327
79WNK40.38794941
80PKN10.37328096
81FLT30.37084483
82PIK3CA0.36760059
83KIT0.36383865
84MAP2K70.34142158
85GRK50.31061433
86CSNK1A10.30736482
87PRKCQ0.29827680
88TRPM70.29752496
89ABL10.29474312
90IRAK20.29124856
91PRKACB0.26367167
92NEK20.26233644
93MUSK0.25908838
94PNCK0.25037600
95MARK10.24233825
96EPHA40.24132185
97DYRK1A0.23420272
98CHUK0.22592378
99IGF1R0.22439385
100TSSK60.21625128

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034403.25632201
2Non-homologous end-joining_Homo sapiens_hsa034502.82455514
3Butanoate metabolism_Homo sapiens_hsa006502.80529776
4Phototransduction_Homo sapiens_hsa047442.54695802
5Fanconi anemia pathway_Homo sapiens_hsa034602.34806065
6Propanoate metabolism_Homo sapiens_hsa006402.32198407
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.29076424
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.25960685
9Tryptophan metabolism_Homo sapiens_hsa003802.24854628
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.12962313
11Nitrogen metabolism_Homo sapiens_hsa009102.11617839
12ABC transporters_Homo sapiens_hsa020102.09114095
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.03182021
14Basal transcription factors_Homo sapiens_hsa030221.96321371
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.95532009
16Linoleic acid metabolism_Homo sapiens_hsa005911.95129183
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.93802942
18One carbon pool by folate_Homo sapiens_hsa006701.87376270
19Caffeine metabolism_Homo sapiens_hsa002321.78573559
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.75132138
21Ether lipid metabolism_Homo sapiens_hsa005651.71192167
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.69537228
23Nicotine addiction_Homo sapiens_hsa050331.68010595
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.65935998
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.64653884
26Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.57418354
27Taste transduction_Homo sapiens_hsa047421.50068932
28Selenocompound metabolism_Homo sapiens_hsa004501.42884945
29RNA polymerase_Homo sapiens_hsa030201.40444728
30Olfactory transduction_Homo sapiens_hsa047401.38725419
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.36281140
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36172058
33Chemical carcinogenesis_Homo sapiens_hsa052041.34547225
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.29278939
35Retinol metabolism_Homo sapiens_hsa008301.25752283
36Protein export_Homo sapiens_hsa030601.24845217
37Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.24116432
38Lysine degradation_Homo sapiens_hsa003101.22494896
39Sphingolipid metabolism_Homo sapiens_hsa006001.19275137
40RNA degradation_Homo sapiens_hsa030181.15714829
41Morphine addiction_Homo sapiens_hsa050321.08071892
42Glycerolipid metabolism_Homo sapiens_hsa005611.07613057
43beta-Alanine metabolism_Homo sapiens_hsa004101.06109128
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.05385359
45Mismatch repair_Homo sapiens_hsa034300.98217915
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.97620223
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.96435328
48Peroxisome_Homo sapiens_hsa041460.92445294
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90730704
50Fatty acid degradation_Homo sapiens_hsa000710.86738519
51Serotonergic synapse_Homo sapiens_hsa047260.85611712
52Salivary secretion_Homo sapiens_hsa049700.83655379
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.80861090
54Purine metabolism_Homo sapiens_hsa002300.79298211
55Arachidonic acid metabolism_Homo sapiens_hsa005900.79202888
56Ovarian steroidogenesis_Homo sapiens_hsa049130.77107637
57Circadian entrainment_Homo sapiens_hsa047130.74559597
58Regulation of autophagy_Homo sapiens_hsa041400.74005813
59Fatty acid biosynthesis_Homo sapiens_hsa000610.73192016
60Glutamatergic synapse_Homo sapiens_hsa047240.68773672
61Histidine metabolism_Homo sapiens_hsa003400.66996157
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.66355404
63Calcium signaling pathway_Homo sapiens_hsa040200.66083967
64Fatty acid metabolism_Homo sapiens_hsa012120.65233054
65GABAergic synapse_Homo sapiens_hsa047270.64269780
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.62842055
67Nucleotide excision repair_Homo sapiens_hsa034200.59803023
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59781084
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.59445611
70Dorso-ventral axis formation_Homo sapiens_hsa043200.58963682
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57747137
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57176774
73Circadian rhythm_Homo sapiens_hsa047100.56459075
74RNA transport_Homo sapiens_hsa030130.52809958
75Long-term depression_Homo sapiens_hsa047300.52363059
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.52250179
77Primary immunodeficiency_Homo sapiens_hsa053400.51457606
78Proteasome_Homo sapiens_hsa030500.50428004
79Metabolic pathways_Homo sapiens_hsa011000.48114084
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47978846
81Base excision repair_Homo sapiens_hsa034100.45780545
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.45386490
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44615224
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41124275
85Asthma_Homo sapiens_hsa053100.40765677
86Cell cycle_Homo sapiens_hsa041100.40732516
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40604587
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40278626
89Insulin secretion_Homo sapiens_hsa049110.39917955
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.37900450
91Pyrimidine metabolism_Homo sapiens_hsa002400.37264712
92p53 signaling pathway_Homo sapiens_hsa041150.36054280
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.35200779
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34491380
95N-Glycan biosynthesis_Homo sapiens_hsa005100.34444238
96Fatty acid elongation_Homo sapiens_hsa000620.31225965
97Glutathione metabolism_Homo sapiens_hsa004800.30623875
98Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.29439230
99Type I diabetes mellitus_Homo sapiens_hsa049400.29078915
100Vitamin digestion and absorption_Homo sapiens_hsa049770.28525376

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