PGBD4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The piggyBac family of proteins, found in diverse animals, are transposases related to the transposase of the canonical piggyBac transposon from the moth, Trichoplusia ni. This family also includes genes in several genomes, including human, that appear to have been derived from the piggyBac transposons. This gene belongs to the subfamily of piggyBac transposable element derived (PGBD) genes. The PGBD proteins appear to be novel, with no obvious relationship to other transposases, or other known protein families. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.38825375
2sulfation (GO:0051923)4.75238615
3L-fucose metabolic process (GO:0042354)4.32459435
4L-fucose catabolic process (GO:0042355)4.32459435
5fucose catabolic process (GO:0019317)4.32459435
6indole-containing compound catabolic process (GO:0042436)4.17016961
7indolalkylamine catabolic process (GO:0046218)4.17016961
8tryptophan catabolic process (GO:0006569)4.17016961
9kynurenine metabolic process (GO:0070189)4.10278221
10indolalkylamine metabolic process (GO:0006586)4.02796011
11DNA deamination (GO:0045006)3.85698135
12water-soluble vitamin biosynthetic process (GO:0042364)3.67721661
13gamma-aminobutyric acid transport (GO:0015812)3.63362013
14negative regulation of mast cell activation (GO:0033004)3.63209895
15cell proliferation in forebrain (GO:0021846)3.56613648
16tryptophan metabolic process (GO:0006568)3.55906617
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.40225588
18mitochondrial respiratory chain complex I assembly (GO:0032981)3.40225588
19NADH dehydrogenase complex assembly (GO:0010257)3.40225588
20neuronal action potential (GO:0019228)3.34989000
21indole-containing compound metabolic process (GO:0042430)3.28449263
22protein polyglutamylation (GO:0018095)3.25222764
23membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.19602557
24negative regulation of telomere maintenance (GO:0032205)3.18482874
25negative regulation of systemic arterial blood pressure (GO:0003085)3.17768885
26cellular response to ATP (GO:0071318)3.13222363
27protein complex biogenesis (GO:0070271)3.10350784
28detection of light stimulus involved in visual perception (GO:0050908)3.08542124
29detection of light stimulus involved in sensory perception (GO:0050962)3.08542124
30negative regulation of synaptic transmission, GABAergic (GO:0032229)3.05944280
31regulation of action potential (GO:0098900)3.05012032
32response to pheromone (GO:0019236)3.02653852
33serotonin metabolic process (GO:0042428)3.02508556
34epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.00010005
35detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.97826719
363-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.97284301
37purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.97284301
38primary amino compound metabolic process (GO:1901160)2.96523488
39reflex (GO:0060004)2.93158583
40cellular ketone body metabolic process (GO:0046950)2.91407758
41piRNA metabolic process (GO:0034587)2.91041693
42regulation of posttranscriptional gene silencing (GO:0060147)2.90239550
43regulation of gene silencing by miRNA (GO:0060964)2.90239550
44regulation of gene silencing by RNA (GO:0060966)2.90239550
45preassembly of GPI anchor in ER membrane (GO:0016254)2.87604445
46platelet dense granule organization (GO:0060155)2.81840864
47mitochondrial respiratory chain complex assembly (GO:0033108)2.80893460
48positive regulation of fatty acid oxidation (GO:0046321)2.79488047
49axoneme assembly (GO:0035082)2.78585610
50amine catabolic process (GO:0009310)2.78246142
51cellular biogenic amine catabolic process (GO:0042402)2.78246142
52neural tube formation (GO:0001841)2.75866529
53spinal cord motor neuron differentiation (GO:0021522)2.75099602
54behavioral response to ethanol (GO:0048149)2.74544461
55negative regulation of transcription regulatory region DNA binding (GO:2000678)2.71714082
56somite development (GO:0061053)2.69048500
57DNA methylation involved in gamete generation (GO:0043046)2.65685205
58startle response (GO:0001964)2.63856331
59transmission of nerve impulse (GO:0019226)2.63257307
60membrane depolarization during action potential (GO:0086010)2.62655778
61ketone body metabolic process (GO:1902224)2.61869035
62photoreceptor cell development (GO:0042461)2.61530498
63kidney morphogenesis (GO:0060993)2.61126071
64regulation of collateral sprouting (GO:0048670)2.58516845
65adaptation of signaling pathway (GO:0023058)2.57729745
66dopamine transport (GO:0015872)2.57065329
67regulation of hippo signaling (GO:0035330)2.56261953
68parturition (GO:0007567)2.55911176
69otic vesicle formation (GO:0030916)2.55646134
70epithelial cilium movement (GO:0003351)2.54401329
71male meiosis I (GO:0007141)2.53089570
72synaptic transmission, cholinergic (GO:0007271)2.50642142
73nephron epithelium morphogenesis (GO:0072088)2.49188816
74nephron tubule morphogenesis (GO:0072078)2.49188816
75positive regulation of cAMP-mediated signaling (GO:0043950)2.48411528
76positive regulation of defense response to virus by host (GO:0002230)2.45027974
77cornea development in camera-type eye (GO:0061303)2.44818816
78regulation of rhodopsin mediated signaling pathway (GO:0022400)2.42414347
79peristalsis (GO:0030432)2.41625318
80regulation of mesoderm development (GO:2000380)2.40891092
81GPI anchor metabolic process (GO:0006505)2.40620303
82regulation of glomerulus development (GO:0090192)2.40162470
83replication fork processing (GO:0031297)2.39718353
84protein K11-linked deubiquitination (GO:0035871)2.38548681
85positive regulation of fatty acid beta-oxidation (GO:0032000)2.38371329
86eye photoreceptor cell development (GO:0042462)2.38304091
87embryonic epithelial tube formation (GO:0001838)2.37629508
88negative regulation by host of viral transcription (GO:0043922)2.36270695
89rhodopsin mediated signaling pathway (GO:0016056)2.36165021
90multicellular organism reproduction (GO:0032504)2.35563491
91cytidine metabolic process (GO:0046087)2.35462477
92cytidine catabolic process (GO:0006216)2.35462477
93cytidine deamination (GO:0009972)2.35462477
94action potential (GO:0001508)2.35199493
95magnesium ion transport (GO:0015693)2.35063488
96regulation of DNA endoreduplication (GO:0032875)2.34270307
97oxidative demethylation (GO:0070989)2.34244828
98benzene-containing compound metabolic process (GO:0042537)2.33825057
99cAMP catabolic process (GO:0006198)2.33729901
100cilium morphogenesis (GO:0060271)2.33005590

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.88563203
2ZNF274_21170338_ChIP-Seq_K562_Hela3.63454556
3GBX2_23144817_ChIP-Seq_PC3_Human3.29310798
4VDR_22108803_ChIP-Seq_LS180_Human3.22164235
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.83136915
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.73087537
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.70160828
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.38904759
9IGF1R_20145208_ChIP-Seq_DFB_Human2.26385570
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19068568
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16567702
12EWS_26573619_Chip-Seq_HEK293_Human2.11539069
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11477012
14FUS_26573619_Chip-Seq_HEK293_Human2.09988386
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04146176
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.99783184
17TAF15_26573619_Chip-Seq_HEK293_Human1.97697531
18P300_19829295_ChIP-Seq_ESCs_Human1.90581397
19ER_23166858_ChIP-Seq_MCF-7_Human1.85370282
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.82416963
21RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78890364
22BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77272995
23* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75442061
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.71722209
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68219297
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.66781713
27BCAT_22108803_ChIP-Seq_LS180_Human1.64474707
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64144187
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62566615
30* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.55677858
31IRF1_19129219_ChIP-ChIP_H3396_Human1.54404423
32PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53363609
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52985322
34STAT3_23295773_ChIP-Seq_U87_Human1.52709692
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52626460
36MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49799217
37* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49482246
38SMAD4_21799915_ChIP-Seq_A2780_Human1.48215513
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45617668
40SALL1_21062744_ChIP-ChIP_HESCs_Human1.45268171
41REST_21632747_ChIP-Seq_MESCs_Mouse1.43697896
42CBP_20019798_ChIP-Seq_JUKART_Human1.41919780
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41919780
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.41766488
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.41609641
46TCF4_23295773_ChIP-Seq_U87_Human1.39797855
47AR_25329375_ChIP-Seq_VCAP_Human1.38394251
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37819937
49* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35302275
50NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33648296
51RNF2_27304074_Chip-Seq_NSC_Mouse1.32239301
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31870468
53JARID2_20064375_ChIP-Seq_MESCs_Mouse1.31808885
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30425433
55AR_21572438_ChIP-Seq_LNCaP_Human1.29861832
56TP53_22573176_ChIP-Seq_HFKS_Human1.29785389
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.28533486
58MYC_18940864_ChIP-ChIP_HL60_Human1.28129021
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27459879
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27459879
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24029871
62PRDM14_20953172_ChIP-Seq_ESCs_Human1.23389268
63EZH2_27304074_Chip-Seq_ESCs_Mouse1.22636707
64SOX2_19829295_ChIP-Seq_ESCs_Human1.21991398
65NANOG_19829295_ChIP-Seq_ESCs_Human1.21991398
66SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21099296
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20743219
68SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.19919170
69TCF4_22108803_ChIP-Seq_LS180_Human1.18864290
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18702143
71FOXA1_25329375_ChIP-Seq_VCAP_Human1.18702143
72FLI1_21867929_ChIP-Seq_TH2_Mouse1.18429835
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18265587
74RUNX2_22187159_ChIP-Seq_PCA_Human1.13781183
75* SMAD4_21741376_ChIP-Seq_EPCs_Human1.13652724
76GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12877502
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.12755544
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12301574
79JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11428147
80EZH2_27294783_Chip-Seq_NPCs_Mouse1.10449376
81* NCOR_22424771_ChIP-Seq_293T_Human1.07593073
82EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06659030
83SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.05948897
84KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05672568
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04523361
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03106797
87CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02786818
88RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02702096
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.02612821
90SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.01930485
91FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01831933
92CRX_20693478_ChIP-Seq_RETINA_Mouse1.00498956
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00095235
94TP53_16413492_ChIP-PET_HCT116_Human0.98973831
95AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98546109
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98116662
97GATA3_21878914_ChIP-Seq_MCF-7_Human0.97549381
98P53_22387025_ChIP-Seq_ESCs_Mouse0.96813862
99AHR_22903824_ChIP-Seq_MCF-7_Human0.96777698
100ARNT_22903824_ChIP-Seq_MCF-7_Human0.96733120

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation2.82346463
2MP0008877_abnormal_DNA_methylation2.81352697
3MP0003195_calcinosis2.56751449
4MP0002102_abnormal_ear_morphology2.42130515
5MP0005551_abnormal_eye_electrophysiolog2.34165539
6MP0001968_abnormal_touch/_nociception2.31594963
7MP0008872_abnormal_physiological_respon2.21057539
8MP0005646_abnormal_pituitary_gland2.16332202
9MP0004142_abnormal_muscle_tone2.10717621
10MP0006292_abnormal_olfactory_placode2.08461220
11MP0009046_muscle_twitch2.07037177
12MP0009745_abnormal_behavioral_response2.02833131
13MP0003646_muscle_fatigue2.01437909
14MP0001485_abnormal_pinna_reflex1.98262298
15MP0004885_abnormal_endolymph1.97828507
16MP0006072_abnormal_retinal_apoptosis1.95414266
17MP0002160_abnormal_reproductive_system1.91572786
18MP0002272_abnormal_nervous_system1.89194883
19MP0002876_abnormal_thyroid_physiology1.88131337
20MP0002837_dystrophic_cardiac_calcinosis1.87382401
21MP0002638_abnormal_pupillary_reflex1.86948905
22MP0000631_abnormal_neuroendocrine_gland1.83855084
23MP0002138_abnormal_hepatobiliary_system1.83119273
24MP0004145_abnormal_muscle_electrophysio1.81927051
25MP0003787_abnormal_imprinting1.81289638
26MP0002736_abnormal_nociception_after1.73671690
27MP0004133_heterotaxia1.70968901
28MP0001986_abnormal_taste_sensitivity1.69683260
29MP0002735_abnormal_chemical_nociception1.66340775
30MP0003880_abnormal_central_pattern1.65970732
31MP0005389_reproductive_system_phenotype1.61384200
32MP0005253_abnormal_eye_physiology1.59282716
33MP0006276_abnormal_autonomic_nervous1.56491063
34MP0002064_seizures1.53102406
35MP0001486_abnormal_startle_reflex1.48945851
36MP0001501_abnormal_sleep_pattern1.45686814
37MP0000427_abnormal_hair_cycle1.41247156
38MP0005084_abnormal_gallbladder_morpholo1.40580567
39MP0002938_white_spotting1.40149446
40MP0000372_irregular_coat_pigmentation1.39882216
41MP0005645_abnormal_hypothalamus_physiol1.38463443
42MP0005174_abnormal_tail_pigmentation1.38010793
43MP0002572_abnormal_emotion/affect_behav1.37686973
44MP0004043_abnormal_pH_regulation1.36923205
45MP0002928_abnormal_bile_duct1.35658693
46MP0004742_abnormal_vestibular_system1.34567191
47MP0000049_abnormal_middle_ear1.30021846
48MP0002653_abnormal_ependyma_morphology1.29426466
49MP0003136_yellow_coat_color1.28945252
50MP0003635_abnormal_synaptic_transmissio1.28131026
51MP0002733_abnormal_thermal_nociception1.27153474
52MP0004147_increased_porphyrin_level1.26532607
53MP0003011_delayed_dark_adaptation1.26041800
54MP0001970_abnormal_pain_threshold1.25405130
55MP0002163_abnormal_gland_morphology1.23320931
56MP0002063_abnormal_learning/memory/cond1.21198203
57MP0002067_abnormal_sensory_capabilities1.18530871
58MP0004130_abnormal_muscle_cell1.18453210
59MP0002557_abnormal_social/conspecific_i1.18444549
60MP0008875_abnormal_xenobiotic_pharmacok1.14999938
61MP0001905_abnormal_dopamine_level1.13224823
62MP0004134_abnormal_chest_morphology1.12972960
63MP0002734_abnormal_mechanical_nocicepti1.11664841
64MP0010386_abnormal_urinary_bladder1.07936441
65MP0005379_endocrine/exocrine_gland_phen1.05964631
66MP0005195_abnormal_posterior_eye1.05285688
67MP0001440_abnormal_grooming_behavior1.04910009
68MP0003890_abnormal_embryonic-extraembry1.04598012
69MP0001919_abnormal_reproductive_system1.04260877
70MP0003937_abnormal_limbs/digits/tail_de1.01061455
71MP0004924_abnormal_behavior0.99918582
72MP0005386_behavior/neurological_phenoty0.99918582
73MP0000383_abnormal_hair_follicle0.98718483
74MP0000026_abnormal_inner_ear0.96487167
75MP0001502_abnormal_circadian_rhythm0.95781410
76MP0002752_abnormal_somatic_nervous0.95599260
77MP0002095_abnormal_skin_pigmentation0.95334471
78MP0001984_abnormal_olfaction0.94299283
79MP0000230_abnormal_systemic_arterial0.92530442
80MP0009250_abnormal_appendicular_skeleto0.90131854
81MP0002184_abnormal_innervation0.89507647
82MP0005083_abnormal_biliary_tract0.88272369
83MP0001963_abnormal_hearing_physiology0.88266267
84MP0004215_abnormal_myocardial_fiber0.87595628
85MP0003119_abnormal_digestive_system0.86975043
86MP0002751_abnormal_autonomic_nervous0.86315300
87MP0000778_abnormal_nervous_system0.85062672
88MP0002277_abnormal_respiratory_mucosa0.84123984
89MP0003252_abnormal_bile_duct0.81906007
90MP0003718_maternal_effect0.81780089
91MP0005671_abnormal_response_to0.74316350
92MP0002234_abnormal_pharynx_morphology0.74147503
93MP0005423_abnormal_somatic_nervous0.72987019
94MP0002229_neurodegeneration0.72731897
95MP0003698_abnormal_male_reproductive0.70673815
96MP0005171_absent_coat_pigmentation0.69775180
97MP0005410_abnormal_fertilization0.69670697
98MP0002882_abnormal_neuron_morphology0.69344309
99MP0000955_abnormal_spinal_cord0.67691118
100MP0003638_abnormal_response/metabolism_0.66334170

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.77352133
2Pancreatic fibrosis (HP:0100732)4.49105297
3True hermaphroditism (HP:0010459)4.22912093
4Molar tooth sign on MRI (HP:0002419)4.09687036
5Abnormality of midbrain morphology (HP:0002418)4.09687036
6Congenital stationary night blindness (HP:0007642)3.63616885
7Pendular nystagmus (HP:0012043)3.61616865
8Abolished electroretinogram (ERG) (HP:0000550)3.56104243
9Genetic anticipation (HP:0003743)3.50247769
10Nephronophthisis (HP:0000090)3.50211719
11Type II lissencephaly (HP:0007260)3.26561118
12Progressive cerebellar ataxia (HP:0002073)3.19917886
13Cystic liver disease (HP:0006706)3.03205774
14Abnormality of the renal medulla (HP:0100957)2.92643142
15Attenuation of retinal blood vessels (HP:0007843)2.87726016
16Absent rod-and cone-mediated responses on ERG (HP:0007688)2.84465514
17Hyperventilation (HP:0002883)2.83190876
18Chronic hepatic failure (HP:0100626)2.81465283
19Abnormality of the renal cortex (HP:0011035)2.80318171
20Increased corneal curvature (HP:0100692)2.80275814
21Keratoconus (HP:0000563)2.80275814
22Furrowed tongue (HP:0000221)2.73089599
23Gaze-evoked nystagmus (HP:0000640)2.71581381
24Abnormal rod and cone electroretinograms (HP:0008323)2.69626877
25Inability to walk (HP:0002540)2.66611479
26Congenital, generalized hypertrichosis (HP:0004540)2.64024309
27Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.62183779
28Abnormality of alanine metabolism (HP:0010916)2.62183779
29Hyperalaninemia (HP:0003348)2.62183779
30Medial flaring of the eyebrow (HP:0010747)2.49709418
31Progressive inability to walk (HP:0002505)2.49518855
32Decreased central vision (HP:0007663)2.46841698
33Congenital sensorineural hearing impairment (HP:0008527)2.46330108
34Sclerocornea (HP:0000647)2.42663697
35Tubular atrophy (HP:0000092)2.39656104
36Decreased electroretinogram (ERG) amplitude (HP:0000654)2.38339163
37Aplasia/Hypoplasia of the tibia (HP:0005772)2.31923660
38Chorioretinal atrophy (HP:0000533)2.28982508
39Concave nail (HP:0001598)2.28271661
40Aplasia/Hypoplasia of the tongue (HP:0010295)2.27554805
41Anencephaly (HP:0002323)2.21867222
42Male pseudohermaphroditism (HP:0000037)2.19825391
43Abnormal drinking behavior (HP:0030082)2.15482524
44Polydipsia (HP:0001959)2.15482524
45Congenital hepatic fibrosis (HP:0002612)2.15478617
46Hypoplasia of the pons (HP:0012110)2.14169708
47Methylmalonic acidemia (HP:0002912)2.13960330
48Clumsiness (HP:0002312)2.13838699
49Small hand (HP:0200055)2.13773563
50Cerebellar dysplasia (HP:0007033)2.13299994
51Large for gestational age (HP:0001520)2.11036769
52Abnormality of the pons (HP:0007361)2.10652519
53Febrile seizures (HP:0002373)2.09770678
54Dynein arm defect of respiratory motile cilia (HP:0012255)2.03611166
55Absent/shortened dynein arms (HP:0200106)2.03611166
56Bony spicule pigmentary retinopathy (HP:0007737)2.03192836
57Agitation (HP:0000713)2.01598853
58Abnormality of DNA repair (HP:0003254)2.01466472
59Aplasia/Hypoplasia of the patella (HP:0006498)2.01450190
60Lissencephaly (HP:0001339)2.01230333
61Protruding tongue (HP:0010808)1.98096894
62Renal cortical cysts (HP:0000803)1.96341116
63Broad-based gait (HP:0002136)1.95112499
64Hemiparesis (HP:0001269)1.93600281
65Aplasia/Hypoplasia of the spleen (HP:0010451)1.93348729
66Decreased circulating renin level (HP:0003351)1.90448057
67Asplenia (HP:0001746)1.90339809
68Patellar aplasia (HP:0006443)1.88684406
69Severe visual impairment (HP:0001141)1.88643918
70Pachygyria (HP:0001302)1.87164467
71Hypothermia (HP:0002045)1.86656830
72Postaxial foot polydactyly (HP:0001830)1.86308889
733-Methylglutaconic aciduria (HP:0003535)1.85849943
74Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84838636
75Abnormality of the renal collecting system (HP:0004742)1.84290055
76Severe muscular hypotonia (HP:0006829)1.84151901
77Focal motor seizures (HP:0011153)1.84040859
78Gait imbalance (HP:0002141)1.83018656
79Methylmalonic aciduria (HP:0012120)1.79669485
80Dialeptic seizures (HP:0011146)1.78274998
81Genital tract atresia (HP:0001827)1.74878768
82Congenital primary aphakia (HP:0007707)1.74429979
83Aplasia/Hypoplasia of the uvula (HP:0010293)1.73634932
84Abnormal biliary tract physiology (HP:0012439)1.73127600
85Bile duct proliferation (HP:0001408)1.73127600
86Focal seizures (HP:0007359)1.71926404
87Tachypnea (HP:0002789)1.71649968
88Polyuria (HP:0000103)1.70745354
89Short tibia (HP:0005736)1.69933771
90Absent thumb (HP:0009777)1.69596699
91Mitochondrial inheritance (HP:0001427)1.69018209
92Abnormality of the phalanges of the 2nd finger (HP:0009541)1.68739731
93Short hallux (HP:0010109)1.68515742
94Optic nerve hypoplasia (HP:0000609)1.68510549
95Aplasia/hypoplasia of the uterus (HP:0008684)1.68293147
96Retinal dysplasia (HP:0007973)1.68081165
97Increased CSF lactate (HP:0002490)1.66762822
98Vaginal atresia (HP:0000148)1.66512278
99Preaxial hand polydactyly (HP:0001177)1.64991231
100Stomach cancer (HP:0012126)1.62007207

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.08331665
2ADRBK23.84134551
3GRK12.99444609
4BMPR1B2.93980175
5TLK12.76879918
6ACVR1B2.41841346
7PINK12.38571258
8ZAK2.37189425
9NUAK12.32255179
10MAP4K22.30265413
11INSRR2.24533367
12TAOK32.11627368
13WNK32.11297863
14WNK41.88565754
15MAPK131.81285643
16CASK1.69507497
17MAP3K41.63031339
18TXK1.58756755
19OXSR11.41232020
20PNCK1.30745176
21MARK11.30587072
22DAPK21.26804403
23ADRBK11.26684355
24PAK31.22961870
25MAP2K71.19869413
26TAF11.14498794
27TNIK1.13213000
28STK391.12429856
29AKT31.10239604
30DYRK21.09546076
31VRK11.08087738
32MKNK21.05929770
33PRKCG0.99803058
34MAPKAPK50.96680897
35NTRK30.92843081
36CAMKK20.92275486
37PRKCE0.90047717
38GRK70.87709963
39IKBKB0.83524088
40BRSK20.83167364
41NTRK20.82752566
42PTK2B0.81298441
43MUSK0.81249586
44PIK3CA0.80054031
45PLK20.79176540
46TEC0.77897825
47RPS6KA50.75586676
48STK160.72934347
49CSNK1G20.72908121
50TIE10.70065337
51TGFBR10.70021690
52CSNK1G10.68265523
53MAP3K90.66885508
54MAPK150.65734061
55SGK20.64741463
56STK110.63163909
57MAPKAPK30.62460552
58TRIM280.60747103
59PRKCQ0.59124933
60CAMK2A0.58473873
61CSNK1G30.57477739
62PRKD20.57437663
63GRK50.57335759
64PKN10.57117678
65MAP2K60.56327778
66NLK0.55173994
67MARK30.53753633
68IRAK10.52329679
69OBSCN0.52056627
70NME10.51865853
71CSNK1A1L0.51344276
72EPHA30.51337261
73SIK20.51277511
74BCKDK0.51195895
75PRKACA0.50433552
76ITK0.48869124
77STK38L0.48563551
78CHUK0.48127325
79PHKG20.47085088
80PHKG10.47085088
81CAMK10.46290367
82KIT0.45317966
83CSNK1A10.44507404
84FLT30.42813175
85PRKCH0.42543687
86PRKCI0.42479864
87SGK4940.41681283
88SGK2230.41681283
89VRK20.41375843
90ERBB20.38338035
91CSNK1D0.36169891
92PRKCZ0.35205616
93RPS6KA60.34659498
94MAP2K40.34597999
95PRKCA0.31912901
96SYK0.31594117
97CHEK20.31443783
98PRKAA10.30664878
99PIM10.29839102
100MKNK10.29716547

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.73027812
2Phototransduction_Homo sapiens_hsa047442.71245775
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.69501364
4Linoleic acid metabolism_Homo sapiens_hsa005912.40087673
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.32985826
6Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.31335419
7Nitrogen metabolism_Homo sapiens_hsa009102.25234131
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.23932301
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.18070624
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.15669851
11Selenocompound metabolism_Homo sapiens_hsa004502.11887731
12Butanoate metabolism_Homo sapiens_hsa006502.07040447
13Oxidative phosphorylation_Homo sapiens_hsa001902.01627334
14Homologous recombination_Homo sapiens_hsa034401.95770853
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.84359965
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.81823544
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.77741628
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74443091
19Basal transcription factors_Homo sapiens_hsa030221.71621392
20Tryptophan metabolism_Homo sapiens_hsa003801.70311066
21Morphine addiction_Homo sapiens_hsa050321.68578605
22Taste transduction_Homo sapiens_hsa047421.68443751
23Ether lipid metabolism_Homo sapiens_hsa005651.61669007
24Protein export_Homo sapiens_hsa030601.60120432
25Parkinsons disease_Homo sapiens_hsa050121.52124780
26Fanconi anemia pathway_Homo sapiens_hsa034601.50612243
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.38783922
28RNA polymerase_Homo sapiens_hsa030201.35872325
29Olfactory transduction_Homo sapiens_hsa047401.35866961
30Chemical carcinogenesis_Homo sapiens_hsa052041.35231323
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34930003
32Caffeine metabolism_Homo sapiens_hsa002321.29740304
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.20712127
34GABAergic synapse_Homo sapiens_hsa047271.20028168
35Glutamatergic synapse_Homo sapiens_hsa047241.17931608
36Steroid hormone biosynthesis_Homo sapiens_hsa001401.17271344
37Cardiac muscle contraction_Homo sapiens_hsa042601.16876691
38Insulin secretion_Homo sapiens_hsa049111.16776948
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.14421955
40ABC transporters_Homo sapiens_hsa020101.13682274
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13429785
42Circadian entrainment_Homo sapiens_hsa047131.12846760
43Serotonergic synapse_Homo sapiens_hsa047261.10496642
44Alzheimers disease_Homo sapiens_hsa050101.02609212
45Huntingtons disease_Homo sapiens_hsa050161.01549243
46Retinol metabolism_Homo sapiens_hsa008300.99668292
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.94697656
48Sulfur metabolism_Homo sapiens_hsa009200.93822838
49Primary immunodeficiency_Homo sapiens_hsa053400.93721661
50Peroxisome_Homo sapiens_hsa041460.91275019
51RNA degradation_Homo sapiens_hsa030180.90551723
52Primary bile acid biosynthesis_Homo sapiens_hsa001200.88253683
53Calcium signaling pathway_Homo sapiens_hsa040200.87015793
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.83307835
55Propanoate metabolism_Homo sapiens_hsa006400.82406347
56Dorso-ventral axis formation_Homo sapiens_hsa043200.77717343
57One carbon pool by folate_Homo sapiens_hsa006700.77474211
58Salivary secretion_Homo sapiens_hsa049700.77228621
59Arachidonic acid metabolism_Homo sapiens_hsa005900.77080758
60Ovarian steroidogenesis_Homo sapiens_hsa049130.75866138
61Regulation of autophagy_Homo sapiens_hsa041400.74723186
62Glycerolipid metabolism_Homo sapiens_hsa005610.74684666
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73963532
64Dopaminergic synapse_Homo sapiens_hsa047280.69545736
65Cholinergic synapse_Homo sapiens_hsa047250.68667376
66Systemic lupus erythematosus_Homo sapiens_hsa053220.68083704
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67578954
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67501644
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.67090838
70Cocaine addiction_Homo sapiens_hsa050300.66302960
71Asthma_Homo sapiens_hsa053100.65076323
72Hedgehog signaling pathway_Homo sapiens_hsa043400.64431175
73Vitamin digestion and absorption_Homo sapiens_hsa049770.63979737
74beta-Alanine metabolism_Homo sapiens_hsa004100.62595698
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.62454868
76Collecting duct acid secretion_Homo sapiens_hsa049660.62090938
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54298418
78Basal cell carcinoma_Homo sapiens_hsa052170.52166315
79Melanoma_Homo sapiens_hsa052180.51639709
80Sulfur relay system_Homo sapiens_hsa041220.50905221
81Long-term depression_Homo sapiens_hsa047300.50628474
82Histidine metabolism_Homo sapiens_hsa003400.49583637
83Purine metabolism_Homo sapiens_hsa002300.47711741
84Gastric acid secretion_Homo sapiens_hsa049710.47433399
85cAMP signaling pathway_Homo sapiens_hsa040240.47211780
86Alcoholism_Homo sapiens_hsa050340.46160841
87Amphetamine addiction_Homo sapiens_hsa050310.44486965
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44480816
89Oxytocin signaling pathway_Homo sapiens_hsa049210.44321008
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.44258920
91Circadian rhythm_Homo sapiens_hsa047100.43872874
92Fat digestion and absorption_Homo sapiens_hsa049750.42938722
93Renin secretion_Homo sapiens_hsa049240.42585286
94Metabolic pathways_Homo sapiens_hsa011000.41351963
95Mineral absorption_Homo sapiens_hsa049780.39987874
96Graft-versus-host disease_Homo sapiens_hsa053320.38315830
97Type II diabetes mellitus_Homo sapiens_hsa049300.37064690
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36993873
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36014901
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35756113

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