ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of catecholamine secretion (GO:0033605)	5.39430496
2	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	5.38612291
3	coenzyme catabolic process (GO:0009109)	5.21122675
4	presynaptic membrane assembly (GO:0097105)	4.97770264
5	histone H3-K9 demethylation (GO:0033169)	4.53016822
6	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	4.47117509
7	negative regulation of synaptic transmission, GABAergic (GO:0032229)	4.43855116
8	regulation of oxidative stress-induced neuron death (GO:1903203)	4.37056584
9	activation of protein kinase B activity (GO:0032148)	4.31111118
10	response to muscle activity (GO:0014850)	4.28119964
11	neurotransmitter-gated ion channel clustering (GO:0072578)	4.27436372
12	DNA integration (GO:0015074)	4.25770466
13	postsynaptic membrane organization (GO:0001941)	4.23561865
14	DNA double-strand break processing (GO:0000729)	4.19512892
15	presynaptic membrane organization (GO:0097090)	4.00429688
16	pyrimidine nucleobase catabolic process (GO:0006208)	3.95403087
17	positive regulation of amine transport (GO:0051954)	3.90582051
18	epithelial cilium movement (GO:0003351)	3.82001392
19	regulation of autophagic vacuole assembly (GO:2000785)	3.75624723
20	cellular response to zinc ion (GO:0071294)	3.73368549
21	neuron cell-cell adhesion (GO:0007158)	3.68460378
22	righting reflex (GO:0060013)	3.67916048
23	ventricular system development (GO:0021591)	3.64746743
24	negative regulation of striated muscle cell apoptotic process (GO:0010664)	3.62814199
25	muscle cell cellular homeostasis (GO:0046716)	3.51273786
26	negative regulation of calcium ion-dependent exocytosis (GO:0045955)	3.42723441
27	positive regulation of amino acid transport (GO:0051957)	3.36172773
28	gamma-aminobutyric acid transport (GO:0015812)	3.35289905
29	microtubule depolymerization (GO:0007019)	3.32476285
30	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	3.32114487
31	protein polyglutamylation (GO:0018095)	3.31354944
32	auditory behavior (GO:0031223)	3.29663559
33	regulation of dopamine secretion (GO:0014059)	3.29623627
34	multicellular organism reproduction (GO:0032504)	3.29327545
35	regulation of phosphoprotein phosphatase activity (GO:0043666)	3.27573952
36	peroxisome fission (GO:0016559)	3.25289998
37	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.22533937
38	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.20862559
39	histone H3-K36 demethylation (GO:0070544)	3.15962676
40	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.14822247
41	regulation of vacuole organization (GO:0044088)	3.10414463
42	startle response (GO:0001964)	3.09159299
43	myofibril assembly (GO:0030239)	3.06675343
44	cilium movement (GO:0003341)	3.03863384
45	ADP metabolic process (GO:0046031)	3.01917007
46	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.01687155
47	nucleobase catabolic process (GO:0046113)	2.92386480
48	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.91622206
49	tongue development (GO:0043586)	2.90747928
50	relaxation of smooth muscle (GO:0044557)	2.89606835
51	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.88328027
52	muscle fiber development (GO:0048747)	2.86324124
53	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.83985281
54	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.82653166
55	positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)	2.82148180
56	histone lysine demethylation (GO:0070076)	2.81670699
57	cGMP-mediated signaling (GO:0019934)	2.81467962
58	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.80419313
59	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.80419313
60	regulation of translation, ncRNA-mediated (GO:0045974)	2.80419313
61	lateral sprouting from an epithelium (GO:0060601)	2.79120999
62	amino acid salvage (GO:0043102)	2.77921618
63	L-methionine salvage (GO:0071267)	2.77921618
64	L-methionine biosynthetic process (GO:0071265)	2.77921618
65	cilium morphogenesis (GO:0060271)	2.77859537
66	histone demethylation (GO:0016577)	2.77674759
67	cofactor catabolic process (GO:0051187)	2.75741047
68	protein dealkylation (GO:0008214)	2.70260856
69	protein demethylation (GO:0006482)	2.70260856
70	negative regulation of DNA binding (GO:0043392)	2.68557116
71	intraciliary transport (GO:0042073)	2.68364269
72	regulation of synaptic transmission, dopaminergic (GO:0032225)	2.67076771
73	regulation of synaptic transmission, GABAergic (GO:0032228)	2.66572769
74	protein localization to cilium (GO:0061512)	2.65928723
75	positive regulation of mitochondrial fission (GO:0090141)	2.65743613
76	nucleoside diphosphate phosphorylation (GO:0006165)	2.63322522
77	seminiferous tubule development (GO:0072520)	2.62411026
78	regulation of relaxation of muscle (GO:1901077)	2.60684543
79	acrosome reaction (GO:0007340)	2.59950190
80	glycosphingolipid biosynthetic process (GO:0006688)	2.57929746
81	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	2.56730356
82	regulation of amino acid transport (GO:0051955)	2.56155158
83	barbed-end actin filament capping (GO:0051016)	2.53170768
84	limb bud formation (GO:0060174)	2.51719885
85	regulation of cofactor metabolic process (GO:0051193)	2.48303231
86	regulation of coenzyme metabolic process (GO:0051196)	2.48303231
87	mRNA cleavage (GO:0006379)	2.46086685
88	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)	2.46020646
89	oligosaccharide biosynthetic process (GO:0009312)	2.43942962
90	regulation of protein kinase A signaling (GO:0010738)	2.43743681
91	single fertilization (GO:0007338)	2.43433735
92	response to nitrosative stress (GO:0051409)	2.42982996
93	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.42383431
94	positive regulation of synaptic transmission, GABAergic (GO:0032230)	2.39751189
95	male meiosis (GO:0007140)	2.38915531
96	regulation of cellular respiration (GO:0043457)	2.37740678
97	response to auditory stimulus (GO:0010996)	2.37243400
98	protein localization to synapse (GO:0035418)	2.37082979
99	motile cilium assembly (GO:0044458)	2.36531422
100	regulation of phospholipase A2 activity (GO:0032429)	2.35367598

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GBX2_23144817_ChIP-Seq_PC3_Human	4.83524853
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.82350858
3	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	4.49807813
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.92468075
5	EZH2_22144423_ChIP-Seq_EOC_Human	3.86665190
6	IGF1R_20145208_ChIP-Seq_DFB_Human	3.49963810
7	VDR_22108803_ChIP-Seq_LS180_Human	2.60514218
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.60170421
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.53805696
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.51983654
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.35070151
12	AR_21572438_ChIP-Seq_LNCaP_Human	2.27927849
13	P300_19829295_ChIP-Seq_ESCs_Human	2.27134848
14	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.21920474
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.18204371
16	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.09631516
17	ER_23166858_ChIP-Seq_MCF-7_Human	2.06975460
18	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.04407920
19	TAF15_26573619_Chip-Seq_HEK293_Human	2.03027801
20	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.01188250
21	FUS_26573619_Chip-Seq_HEK293_Human	1.93725719
22	SMAD4_21799915_ChIP-Seq_A2780_Human	1.89335315
23	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.66089230
24	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.66029224
25	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.66020742
26	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.65735774
27	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.64237328
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.62004186
29	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.60411819
30	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.58711189
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.58002418
32	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.57320883
33	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.55526063
34	EWS_26573619_Chip-Seq_HEK293_Human	1.53118394
35	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.51794853
36	RNF2_27304074_Chip-Seq_NSC_Mouse	1.51714880
37	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.50710128
38	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.47377596
39	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.47027892
40	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.45841025
41	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.45829316
42	BCAT_22108803_ChIP-Seq_LS180_Human	1.42926662
43	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.42350106
44	CBP_20019798_ChIP-Seq_JUKART_Human	1.42350106
45	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.41867216
46	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.41010021
47	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.40808523
48	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.40026385
49	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.39929425
50	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.35960483
51	RUNX2_22187159_ChIP-Seq_PCA_Human	1.35391996
52	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.31027880
53	TCF4_23295773_ChIP-Seq_U87_Human	1.30547513
54	RXR_22108803_ChIP-Seq_LS180_Human	1.28891094
55	TCF4_22108803_ChIP-Seq_LS180_Human	1.28715977
56	STAT3_23295773_ChIP-Seq_U87_Human	1.23851604
57	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.22952745
58	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.22952745
59	AR_25329375_ChIP-Seq_VCAP_Human	1.22843739
60	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.22189479
61	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.21066576
62	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.21057994
63	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.20993274
64	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.20550913
65	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.16902975
66	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.15385621
67	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.13262696
68	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.12896291
69	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.12475077
70	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.11756470
71	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.11492718
72	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.09956486
73	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.09832131
74	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.07956021
75	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.07956021
76	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.07631115
77	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.06334038
78	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.05855781
79	TP53_18474530_ChIP-ChIP_U2OS_Human	1.05613547
80	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.05159398
81	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.04070706
82	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.03956757
83	TBL1_22424771_ChIP-Seq_293T_Human	1.03853005
84	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.02427670
85	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.00281878
86	REST_21632747_ChIP-Seq_MESCs_Mouse	0.99563768
87	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.98124944
88	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.97827413
89	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.97610016
90	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.96230705
91	CBP_21632823_ChIP-Seq_H3396_Human	0.95950070
92	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.94961811
93	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.94637433
94	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.94593729
95	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.94051679
96	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.93896176
97	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.93679383
98	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.92187653
99	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.92047234
100	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.90304644

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001529_abnormal_vocalization	5.07233836
2	MP0001984_abnormal_olfaction	3.11112506
3	MP0002837_dystrophic_cardiac_calcinosis	2.93892092
4	MP0002102_abnormal_ear_morphology	2.75864047
5	MP0006072_abnormal_retinal_apoptosis	2.74318779
6	MP0005499_abnormal_olfactory_system	2.68930341
7	MP0005394_taste/olfaction_phenotype	2.68930341
8	MP0004859_abnormal_synaptic_plasticity	2.68295181
9	MP0005248_abnormal_Harderian_gland	2.61864152
10	MP0003880_abnormal_central_pattern	2.58581865
11	MP0000749_muscle_degeneration	2.50146880
12	MP0008004_abnormal_stomach_pH	2.47196747
13	MP0008789_abnormal_olfactory_epithelium	2.37690638
14	MP0004084_abnormal_cardiac_muscle	2.21824662
15	MP0005253_abnormal_eye_physiology	2.14730175
16	MP0004270_analgesia	2.08998811
17	MP0003806_abnormal_nucleotide_metabolis	2.06079649
18	MP0009046_muscle_twitch	2.04114997
19	MP0006292_abnormal_olfactory_placode	1.94502576
20	MP0000537_abnormal_urethra_morphology	1.94500033
21	MP0009697_abnormal_copulation	1.86874901
22	MP0004215_abnormal_myocardial_fiber	1.82320266
23	MP0001486_abnormal_startle_reflex	1.80408886
24	MP0000049_abnormal_middle_ear	1.77574210
25	MP0006276_abnormal_autonomic_nervous	1.77389392
26	MP0001485_abnormal_pinna_reflex	1.66719755
27	MP0005187_abnormal_penis_morphology	1.61292529
28	MP0000778_abnormal_nervous_system	1.57897665
29	MP0002127_abnormal_cardiovascular_syste	1.53403495
30	MP0002160_abnormal_reproductive_system	1.51597832
31	MP0003315_abnormal_perineum_morphology	1.47576677
32	MP0003136_yellow_coat_color	1.44634376
33	MP0003635_abnormal_synaptic_transmissio	1.41991471
34	MP0005646_abnormal_pituitary_gland	1.40350330
35	MP0004036_abnormal_muscle_relaxation	1.38294359
36	MP0001502_abnormal_circadian_rhythm	1.37373982
37	MP0009745_abnormal_behavioral_response	1.37195443
38	MP0010368_abnormal_lymphatic_system	1.35196312
39	MP0004924_abnormal_behavior	1.34470532
40	MP0005386_behavior/neurological_phenoty	1.34470532
41	MP0000750_abnormal_muscle_regeneration	1.32425172
42	MP0002272_abnormal_nervous_system	1.31325642
43	MP0001905_abnormal_dopamine_level	1.30743894
44	MP0002734_abnormal_mechanical_nocicepti	1.27481676
45	MP0002233_abnormal_nose_morphology	1.27285946
46	MP0002822_catalepsy	1.23338566
47	MP0001501_abnormal_sleep_pattern	1.23171047
48	MP0003938_abnormal_ear_development	1.20469642
49	MP0004811_abnormal_neuron_physiology	1.17613560
50	MP0002064_seizures	1.15427804
51	MP0002751_abnormal_autonomic_nervous	1.15311878
52	MP0000566_synostosis	1.14913275
53	MP0004885_abnormal_endolymph	1.14582617
54	MP0004272_abnormal_basement_membrane	1.12115607
55	MP0000631_abnormal_neuroendocrine_gland	1.11548930
56	MP0002572_abnormal_emotion/affect_behav	1.10555614
57	MP0003122_maternal_imprinting	1.10493651
58	MP0005391_vision/eye_phenotype	1.09432343
59	MP0010386_abnormal_urinary_bladder	1.09272639
60	MP0003385_abnormal_body_wall	1.08833527
61	MP0001968_abnormal_touch/_nociception	1.04321480
62	MP0005551_abnormal_eye_electrophysiolog	1.01555976
63	MP0001664_abnormal_digestion	1.00791729
64	MP0002063_abnormal_learning/memory/cond	1.00082289
65	MP0002269_muscular_atrophy	1.00058869
66	MP0000026_abnormal_inner_ear	0.99047648
67	MP0005330_cardiomyopathy	0.98380176
68	MP0003755_abnormal_palate_morphology	0.97677371
69	MP0009250_abnormal_appendicular_skeleto	0.97343292
70	MP0002557_abnormal_social/conspecific_i	0.95470490
71	MP0008877_abnormal_DNA_methylation	0.94186770
72	MP0005623_abnormal_meninges_morphology	0.94137231
73	MP0004147_increased_porphyrin_level	0.93931792
74	MP0000751_myopathy	0.93523274
75	MP0005620_abnormal_muscle_contractility	0.92390327
76	MP0002282_abnormal_trachea_morphology	0.91249984
77	MP0002638_abnormal_pupillary_reflex	0.89594689
78	MP0002108_abnormal_muscle_morphology	0.89560519
79	MP0002184_abnormal_innervation	0.88669838
80	MP0002132_abnormal_respiratory_system	0.88559310
81	MP0002736_abnormal_nociception_after	0.88203636
82	MP0002067_abnormal_sensory_capabilities	0.87301449
83	MP0003119_abnormal_digestive_system	0.87072842
84	MP0000534_abnormal_ureter_morphology	0.86922283
85	MP0002882_abnormal_neuron_morphology	0.86644558
86	MP0004484_altered_response_of	0.85589900
87	MP0002752_abnormal_somatic_nervous	0.84639033
88	MP0006036_abnormal_mitochondrial_physio	0.83971105
89	MP0001963_abnormal_hearing_physiology	0.79398966
90	MP0001270_distended_abdomen	0.76922347
91	MP0003633_abnormal_nervous_system	0.74915380
92	MP0002735_abnormal_chemical_nociception	0.74799505
93	MP0005410_abnormal_fertilization	0.74266485
94	MP0003698_abnormal_male_reproductive	0.73541438
95	MP0005367_renal/urinary_system_phenotyp	0.73252739
96	MP0000516_abnormal_urinary_system	0.73252739
97	MP0000955_abnormal_spinal_cord	0.70649251
98	MP0000747_muscle_weakness	0.69251922
99	MP0002234_abnormal_pharynx_morphology	0.69235028
100	MP0001544_abnormal_cardiovascular_syste	0.69172678

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Retinal dysplasia (HP:0007973)	4.72155181
2	Cerebellar dysplasia (HP:0007033)	3.86266022
3	Rimmed vacuoles (HP:0003805)	3.66557756
4	Median cleft lip (HP:0000161)	3.64332247
5	Inability to walk (HP:0002540)	3.43471203
6	High anterior hairline (HP:0009890)	3.40149089
7	Type II lissencephaly (HP:0007260)	3.25070939
8	Sensory axonal neuropathy (HP:0003390)	3.08556351
9	Clumsiness (HP:0002312)	3.06273741
10	Abnormality of the shoulder girdle musculature (HP:0001435)	3.02526106
11	Progressive inability to walk (HP:0002505)	3.01424276
12	Chronic hepatic failure (HP:0100626)	2.98709261
13	Pendular nystagmus (HP:0012043)	2.94029781
14	Urinary urgency (HP:0000012)	2.92193163
15	Atonic seizures (HP:0010819)	2.86642178
16	Poor eye contact (HP:0000817)	2.86253852
17	Short 4th metacarpal (HP:0010044)	2.81345046
18	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	2.81345046
19	Scapular winging (HP:0003691)	2.76576255
20	Hyporeflexia of lower limbs (HP:0002600)	2.75222806
21	Pancreatic fibrosis (HP:0100732)	2.74909009
22	Postaxial hand polydactyly (HP:0001162)	2.72761166
23	Abnormality of the columella (HP:0009929)	2.71980673
24	Absent speech (HP:0001344)	2.71075564
25	Exercise-induced muscle cramps (HP:0003710)	2.68065815
26	Renal dysplasia (HP:0000110)	2.64814539
27	Resting tremor (HP:0002322)	2.60221988
28	True hermaphroditism (HP:0010459)	2.54461690
29	Long clavicles (HP:0000890)	2.50413057
30	Focal motor seizures (HP:0011153)	2.50265289
31	Abnormality of the calf musculature (HP:0001430)	2.46963162
32	Generalized tonic-clonic seizures (HP:0002069)	2.44611232
33	Progressive cerebellar ataxia (HP:0002073)	2.44129303
34	Impaired social interactions (HP:0000735)	2.42758352
35	Abnormal social behavior (HP:0012433)	2.42758352
36	Pancreatic cysts (HP:0001737)	2.40040618
37	Tented upper lip vermilion (HP:0010804)	2.38348558
38	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.33977678
39	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.30682877
40	Abnormal lung lobation (HP:0002101)	2.29279323
41	Calf muscle hypertrophy (HP:0008981)	2.28082352
42	Postaxial foot polydactyly (HP:0001830)	2.26763740
43	Mutism (HP:0002300)	2.21410991
44	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.21341683
45	Short tibia (HP:0005736)	2.18616821
46	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	2.16615583
47	Polyphagia (HP:0002591)	2.14484793
48	Bifid scrotum (HP:0000048)	2.10251480
49	Broad-based gait (HP:0002136)	2.09340327
50	Optic nerve hypoplasia (HP:0000609)	2.07996236
51	Eosinophilia (HP:0001880)	2.07069832
52	Pachygyria (HP:0001302)	2.06950187
53	Proximal amyotrophy (HP:0007126)	2.06234587
54	Muscle hypertrophy of the lower extremities (HP:0008968)	2.02850422
55	Morphological abnormality of the middle ear (HP:0008609)	2.02596455
56	Abnormality of macular pigmentation (HP:0008002)	2.01494408
57	Premature ovarian failure (HP:0008209)	2.00922455
58	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.97334781
59	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.97334781
60	Renal hypoplasia (HP:0000089)	1.96936350
61	Nephrogenic diabetes insipidus (HP:0009806)	1.96404177
62	Esotropia (HP:0000565)	1.96163242
63	Fibular aplasia (HP:0002990)	1.95119986
64	Gait imbalance (HP:0002141)	1.94599276
65	Hyperglycinemia (HP:0002154)	1.93910643
66	Cortical dysplasia (HP:0002539)	1.93050538
67	Molar tooth sign on MRI (HP:0002419)	1.92048611
68	Abnormality of midbrain morphology (HP:0002418)	1.92048611
69	Partial agenesis of the corpus callosum (HP:0001338)	1.91996685
70	Intellectual disability, progressive (HP:0006887)	1.90090494
71	Diaphragmatic weakness (HP:0009113)	1.89339658
72	Genital tract atresia (HP:0001827)	1.88471827
73	Steppage gait (HP:0003376)	1.87947100
74	Abnormal respiratory motile cilium physiology (HP:0012261)	1.87576524
75	Abnormal ciliary motility (HP:0012262)	1.87403272
76	Abnormal eating behavior (HP:0100738)	1.87306606
77	Abnormality of lateral ventricle (HP:0030047)	1.86807059
78	Abnormality of the frontal sinuses (HP:0002687)	1.86527836
79	Abnormality of the 4th metacarpal (HP:0010012)	1.85977924
80	Spinal rigidity (HP:0003306)	1.85855459
81	Postural instability (HP:0002172)	1.85743432
82	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	1.85451125
83	Dysdiadochokinesis (HP:0002075)	1.84797039
84	Medial flaring of the eyebrow (HP:0010747)	1.83612724
85	Facial hemangioma (HP:0000329)	1.83251143
86	Abnormality of the incisor (HP:0000676)	1.81430237
87	Congenital primary aphakia (HP:0007707)	1.80944058
88	Lissencephaly (HP:0001339)	1.80397633
89	Cupped ear (HP:0000378)	1.78901678
90	Muscular dystrophy (HP:0003560)	1.78892814
91	Protruding tongue (HP:0010808)	1.76684318
92	Pancreatic islet-cell hyperplasia (HP:0004510)	1.76391324
93	Myoglobinuria (HP:0002913)	1.75390497
94	Recurrent corneal erosions (HP:0000495)	1.74616489
95	Drooling (HP:0002307)	1.74222948
96	Exercise-induced myalgia (HP:0003738)	1.74158997
97	Myokymia (HP:0002411)	1.74021132
98	Delayed CNS myelination (HP:0002188)	1.72995551
99	Anencephaly (HP:0002323)	1.72053573
100	Focal seizures (HP:0007359)	1.72052025

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	6.32175771
2	OBSCN	3.35479727
3	MARK3	3.01970486
4	MAP2K7	2.96332170
5	LATS1	2.87513359
6	FRK	2.62293066
7	CDK3	2.51296638
8	CSNK1A1L	2.39106681
9	NEK2	2.35701490
10	MARK1	2.28310282
11	PBK	2.23459439
12	STK38L	2.14241683
13	CSNK1G3	2.13440568
14	BMPR1B	2.13096951
15	DYRK3	2.10301098
16	DYRK2	1.99100186
17	MAPK13	1.97287377
18	RPS6KA4	1.96433183
19	CSNK1G2	1.90091956
20	MAP3K4	1.85456195
21	WNK3	1.83782862
22	NTRK2	1.78897320
23	CSNK1G1	1.78891538
24	CLK1	1.72622844
25	MAP4K2	1.56394747
26	MYLK	1.55154931
27	SGK223	1.27804501
28	SGK494	1.27804501
29	SRPK1	1.25850527
30	BCR	1.24950098
31	CASK	1.23415049
32	MAPK15	1.16965162
33	EPHB2	1.14166363
34	MINK1	1.13063320
35	TGFBR1	1.10716409
36	SGK2	1.03706487
37	PLK4	1.01018643
38	LATS2	0.94551318
39	PKN1	0.92122186
40	TLK1	0.90690367
41	PRKG2	0.85463326
42	WEE1	0.84786343
43	CDK14	0.84222289
44	TNIK	0.82008672
45	TRIM28	0.80492251
46	CDK8	0.80392238
47	PHKG1	0.77877388
48	PHKG2	0.77877388
49	INSRR	0.77323252
50	CDK5	0.74972267
51	TIE1	0.74139424
52	RPS6KA5	0.72283228
53	RPS6KB1	0.69430898
54	MOS	0.67959682
55	EPHA4	0.66100253
56	CDK19	0.63813507
57	GRK1	0.63775937
58	CAMK2B	0.63607257
59	FGFR2	0.62753551
60	NTRK3	0.62496380
61	BCKDK	0.62383527
62	PLK2	0.61554821
63	CCNB1	0.60849809
64	ARAF	0.59166858
65	ROCK1	0.59092344
66	STK16	0.58721187
67	ERBB3	0.58020019
68	CAMK2G	0.57100408
69	CAMK2A	0.56800802
70	CAMK4	0.56502954
71	CSNK1A1	0.54776900
72	PRKCE	0.54538384
73	BRD4	0.54225196
74	NLK	0.54199635
75	CSNK1D	0.51984906
76	MAP3K5	0.50427640
77	CAMK1	0.49934666
78	CAMK2D	0.49659102
79	ADRBK2	0.48285604
80	MAPKAPK5	0.47176241
81	ROCK2	0.44320372
82	STK39	0.43923820
83	EGFR	0.42494066
84	CDK18	0.41128732
85	GRK5	0.40090788
86	PIK3CA	0.39887837
87	AURKB	0.39694347
88	CDK15	0.39398367
89	PRKG1	0.36867541
90	CDK11A	0.36492783
91	PRKCQ	0.36305647
92	STK38	0.34950196
93	NEK1	0.34194291
94	PRKACB	0.33038613
95	OXSR1	0.32563789
96	PRKACA	0.31377610
97	PAK6	0.30932351
98	PRKCG	0.29231296
99	MUSK	0.28935246
100	PLK1	0.28131353

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	3.44986599
2	Nicotine addiction_Homo sapiens_hsa05033	3.24064379
3	Olfactory transduction_Homo sapiens_hsa04740	2.92955959
4	Butanoate metabolism_Homo sapiens_hsa00650	2.84542321
5	GABAergic synapse_Homo sapiens_hsa04727	2.47566268
6	Circadian rhythm_Homo sapiens_hsa04710	2.20171122
7	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.18813554
8	Basal transcription factors_Homo sapiens_hsa03022	1.98111930
9	Circadian entrainment_Homo sapiens_hsa04713	1.95158449
10	Chemical carcinogenesis_Homo sapiens_hsa05204	1.87944576
11	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.86000241
12	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.73714925
13	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.73317500
14	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.70735698
15	Nitrogen metabolism_Homo sapiens_hsa00910	1.67419044
16	Regulation of autophagy_Homo sapiens_hsa04140	1.63472071
17	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.57273006
18	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.49785902
19	Propanoate metabolism_Homo sapiens_hsa00640	1.47007067
20	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.46716368
21	Morphine addiction_Homo sapiens_hsa05032	1.42888572
22	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.39697903
23	Cocaine addiction_Homo sapiens_hsa05030	1.39030488
24	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.36374328
25	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.35291269
26	Taste transduction_Homo sapiens_hsa04742	1.29192476
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.28917495
28	beta-Alanine metabolism_Homo sapiens_hsa00410	1.28908128
29	Amphetamine addiction_Homo sapiens_hsa05031	1.28660446
30	Oocyte meiosis_Homo sapiens_hsa04114	1.25132595
31	Dopaminergic synapse_Homo sapiens_hsa04728	1.23154943
32	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.18318141
33	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.18306873
34	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.16210210
35	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.13923398
36	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.13806084
37	Arginine biosynthesis_Homo sapiens_hsa00220	1.09702801
38	Gap junction_Homo sapiens_hsa04540	1.09232776
39	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.08031134
40	Renin secretion_Homo sapiens_hsa04924	1.07615026
41	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.07608861
42	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.06978403
43	Steroid biosynthesis_Homo sapiens_hsa00100	1.05367106
44	Salivary secretion_Homo sapiens_hsa04970	1.04441964
45	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.04218791
46	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.02911878
47	Glutamatergic synapse_Homo sapiens_hsa04724	1.02268350
48	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.01773400
49	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.00931557
50	Phototransduction_Homo sapiens_hsa04744	0.98369950
51	Axon guidance_Homo sapiens_hsa04360	0.98164578
52	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.97928506
53	Basal cell carcinoma_Homo sapiens_hsa05217	0.97052339
54	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.95223277
55	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.92659806
56	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.92487350
57	Alcoholism_Homo sapiens_hsa05034	0.92403169
58	RNA degradation_Homo sapiens_hsa03018	0.91129670
59	Phenylalanine metabolism_Homo sapiens_hsa00360	0.91051722
60	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.88703936
61	Insulin secretion_Homo sapiens_hsa04911	0.84523393
62	Gastric acid secretion_Homo sapiens_hsa04971	0.83030560
63	Calcium signaling pathway_Homo sapiens_hsa04020	0.82306926
64	AMPK signaling pathway_Homo sapiens_hsa04152	0.81091987
65	Retinol metabolism_Homo sapiens_hsa00830	0.80971305
66	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.78501852
67	Tyrosine metabolism_Homo sapiens_hsa00350	0.75623576
68	Collecting duct acid secretion_Homo sapiens_hsa04966	0.74257675
69	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.74202857
70	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.73855186
71	cAMP signaling pathway_Homo sapiens_hsa04024	0.71466289
72	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.70344891
73	Purine metabolism_Homo sapiens_hsa00230	0.69100282
74	Parkinsons disease_Homo sapiens_hsa05012	0.67779171
75	Peroxisome_Homo sapiens_hsa04146	0.66861265
76	Glutathione metabolism_Homo sapiens_hsa00480	0.65190061
77	Tryptophan metabolism_Homo sapiens_hsa00380	0.64502892
78	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.62273983
79	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.62060752
80	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.61582080
81	Cholinergic synapse_Homo sapiens_hsa04725	0.61083901
82	Wnt signaling pathway_Homo sapiens_hsa04310	0.60683837
83	Arginine and proline metabolism_Homo sapiens_hsa00330	0.58969996
84	Hippo signaling pathway_Homo sapiens_hsa04390	0.56842766
85	PPAR signaling pathway_Homo sapiens_hsa03320	0.56700278
86	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.56402886
87	Cardiac muscle contraction_Homo sapiens_hsa04260	0.54903101
88	Tight junction_Homo sapiens_hsa04530	0.52998602
89	Glucagon signaling pathway_Homo sapiens_hsa04922	0.52922853
90	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.50143059
91	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.49591503
92	Non-homologous end-joining_Homo sapiens_hsa03450	0.46742292
93	Metabolic pathways_Homo sapiens_hsa01100	0.45127846
94	mRNA surveillance pathway_Homo sapiens_hsa03015	0.44489888
95	ABC transporters_Homo sapiens_hsa02010	0.43119071
96	Fatty acid degradation_Homo sapiens_hsa00071	0.42998179
97	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.42826014
98	RNA polymerase_Homo sapiens_hsa03020	0.39115887
99	Melanogenesis_Homo sapiens_hsa04916	0.39072531
100	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.38433131

PGBD4P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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