PGBD5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The piggyBac family of proteins, found in diverse animals, are transposases related to the transposase of the canonical piggyBac transposon from the moth, Trichoplusia ni. This family also includes genes in several genomes, including human, that appear to have been derived from the piggyBac transposons. This gene belongs to the subfamily of piggyBac transposable element derived (PGBD) genes. The PGBD proteins appear to be novel, with no obvious relationship to other transposases, or other known protein families. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.00285554
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.76584535
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.64418773
4vocalization behavior (GO:0071625)5.57622000
5synaptic vesicle exocytosis (GO:0016079)5.56911060
6synaptic vesicle maturation (GO:0016188)5.36088154
7glutamate secretion (GO:0014047)5.28934181
8locomotory exploration behavior (GO:0035641)5.27276044
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.20142235
10regulation of glutamate receptor signaling pathway (GO:1900449)5.15545026
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.09435971
12regulation of synaptic vesicle exocytosis (GO:2000300)4.99549928
13protein localization to synapse (GO:0035418)4.96462994
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.90824222
15neurotransmitter-gated ion channel clustering (GO:0072578)4.83624577
16regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.72425347
17neuronal action potential propagation (GO:0019227)4.68695082
18neuron cell-cell adhesion (GO:0007158)4.67746239
19synaptic transmission, glutamatergic (GO:0035249)4.60359026
20regulation of synaptic vesicle transport (GO:1902803)4.50925168
21glutamate receptor signaling pathway (GO:0007215)4.50688166
22regulation of neuronal synaptic plasticity (GO:0048168)4.43801333
23neuron-neuron synaptic transmission (GO:0007270)4.40107519
24regulation of long-term neuronal synaptic plasticity (GO:0048169)4.32542353
25neurotransmitter secretion (GO:0007269)4.28579125
26positive regulation of synapse maturation (GO:0090129)4.24469188
27exploration behavior (GO:0035640)4.17373559
28regulation of excitatory postsynaptic membrane potential (GO:0060079)4.10820635
29negative regulation of synaptic transmission, GABAergic (GO:0032229)3.98433396
30membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.97767437
31sodium ion export (GO:0071436)3.93431309
32positive regulation of membrane potential (GO:0045838)3.93175230
33regulation of synapse structural plasticity (GO:0051823)3.92076614
34gamma-aminobutyric acid signaling pathway (GO:0007214)3.92025086
35axon ensheathment in central nervous system (GO:0032291)3.88915185
36central nervous system myelination (GO:0022010)3.88915185
37regulation of postsynaptic membrane potential (GO:0060078)3.88087877
38long-term synaptic potentiation (GO:0060291)3.84982503
39regulation of synaptic plasticity (GO:0048167)3.84917791
40long-term memory (GO:0007616)3.83563335
41presynaptic membrane assembly (GO:0097105)3.75803859
42synaptic vesicle endocytosis (GO:0048488)3.69847105
43gamma-aminobutyric acid transport (GO:0015812)3.68749245
44G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.59932161
45L-amino acid import (GO:0043092)3.58967840
46presynaptic membrane organization (GO:0097090)3.58796561
47postsynaptic membrane organization (GO:0001941)3.58700724
48regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.58432877
49regulation of dendritic spine morphogenesis (GO:0061001)3.58411256
50cellular potassium ion homeostasis (GO:0030007)3.57960950
51regulation of synaptic transmission, glutamatergic (GO:0051966)3.57027915
52transmission of nerve impulse (GO:0019226)3.54896363
53regulation of neurotransmitter secretion (GO:0046928)3.53423695
54dendritic spine morphogenesis (GO:0060997)3.53314135
55cerebellar Purkinje cell differentiation (GO:0021702)3.51699544
56neurotransmitter transport (GO:0006836)3.50513535
57cerebellar granule cell differentiation (GO:0021707)3.48101513
58serotonin metabolic process (GO:0042428)3.47560525
59potassium ion import (GO:0010107)3.47455460
60neuromuscular synaptic transmission (GO:0007274)3.46196409
61neuron recognition (GO:0008038)3.44670370
62positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.44116267
63positive regulation of neurotransmitter secretion (GO:0001956)3.41744121
64neuronal ion channel clustering (GO:0045161)3.41428938
65positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.39594006
66regulation of synapse maturation (GO:0090128)3.39268381
67response to histamine (GO:0034776)3.38696349
68potassium ion homeostasis (GO:0055075)3.35803215
69behavioral defense response (GO:0002209)3.32606436
70behavioral fear response (GO:0001662)3.32606436
71membrane depolarization (GO:0051899)3.32335997
72layer formation in cerebral cortex (GO:0021819)3.31719790
73proline transport (GO:0015824)3.26437319
74regulation of neurotransmitter transport (GO:0051588)3.25662044
75regulation of glutamate secretion (GO:0014048)3.25382747
76positive regulation of neurotransmitter transport (GO:0051590)3.24031034
77regulation of vesicle fusion (GO:0031338)3.23965422
78regulation of neurotransmitter levels (GO:0001505)3.23509719
79neurotransmitter uptake (GO:0001504)3.22757291
80membrane depolarization during action potential (GO:0086010)3.20369309
81innervation (GO:0060384)3.17852634
82auditory behavior (GO:0031223)3.16924719
83neuromuscular process controlling balance (GO:0050885)3.16211914
84regulation of synaptic transmission (GO:0050804)3.15537316
85positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.15110043
86primary amino compound metabolic process (GO:1901160)3.15044864
87fear response (GO:0042596)3.14974214
88learning (GO:0007612)3.14699304
89positive regulation of synaptic transmission (GO:0050806)3.13404667
90synaptic transmission (GO:0007268)3.13070284
91long term synaptic depression (GO:0060292)3.12739694
92behavioral response to cocaine (GO:0048148)3.12588845
93negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.12352218
94regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.11758418
95membrane hyperpolarization (GO:0060081)3.11090918
96regulation of dendritic spine development (GO:0060998)3.08116663
97G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.08075412
98regulation of female receptivity (GO:0045924)3.08007750
99negative regulation of dendrite morphogenesis (GO:0050774)3.06843333
100positive regulation of synaptic transmission, GABAergic (GO:0032230)3.06839865
101axonal fasciculation (GO:0007413)3.06687302
102positive regulation of dendritic spine morphogenesis (GO:0061003)3.06497657
103activation of protein kinase A activity (GO:0034199)3.04262687
104startle response (GO:0001964)3.03974985
105cellular sodium ion homeostasis (GO:0006883)3.03743939
106response to auditory stimulus (GO:0010996)3.02863991
107regulation of voltage-gated calcium channel activity (GO:1901385)3.00785144
108amino acid import (GO:0043090)2.99718926
109neuromuscular process controlling posture (GO:0050884)2.99689188
110synapse assembly (GO:0007416)2.98733351
111negative regulation of amino acid transport (GO:0051956)2.98692996
112behavioral response to nicotine (GO:0035095)2.98611870
113adult walking behavior (GO:0007628)2.97916646
114dendritic spine organization (GO:0097061)2.97062919
115mechanosensory behavior (GO:0007638)2.96829122
116regulation of calcium ion-dependent exocytosis (GO:0017158)2.96515986
117cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.96209785
118female mating behavior (GO:0060180)2.96153928
119positive regulation of dendritic spine development (GO:0060999)2.95938297
120negative regulation of cytosolic calcium ion concentration (GO:0051481)2.94929401
121potassium ion transmembrane transport (GO:0071805)2.89759501
122cellular potassium ion transport (GO:0071804)2.89759501
123cell differentiation in hindbrain (GO:0021533)2.88646328
124acidic amino acid transport (GO:0015800)2.86768090
125neuromuscular process (GO:0050905)2.86445284
126regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.86347691

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.24453444
2GBX2_23144817_ChIP-Seq_PC3_Human3.93746422
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.18014372
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.11529250
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.08904620
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.76357642
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.70672794
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.70672794
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.66261439
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.65537432
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.60488954
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53085771
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.51530410
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.47295378
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.46569618
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.45784531
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.35468833
18DROSHA_22980978_ChIP-Seq_HELA_Human2.34771917
19* REST_18959480_ChIP-ChIP_MESCs_Mouse2.25386357
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.21849032
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.21814231
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.20735979
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.09704139
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.02562392
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.95696983
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90485633
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.88699242
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.86790349
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.83099753
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82341854
31TAF15_26573619_Chip-Seq_HEK293_Human1.79791828
32SMAD4_21799915_ChIP-Seq_A2780_Human1.77268808
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75622180
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75390194
35AR_21572438_ChIP-Seq_LNCaP_Human1.68120634
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66310646
37* P300_19829295_ChIP-Seq_ESCs_Human1.55319387
38* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46752854
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45714471
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44631608
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.42873960
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.42224238
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40561743
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.38296009
45* SMAD3_21741376_ChIP-Seq_EPCs_Human1.37024445
46* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.35461721
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32008158
48AR_25329375_ChIP-Seq_VCAP_Human1.31884341
49SOX2_21211035_ChIP-Seq_LN229_Gbm1.31451917
50* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30213268
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.28858602
52* STAT3_23295773_ChIP-Seq_U87_Human1.28540677
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26459760
54RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.26181402
55ZNF274_21170338_ChIP-Seq_K562_Hela1.25550208
56RING1B_27294783_Chip-Seq_ESCs_Mouse1.23235358
57RNF2_27304074_Chip-Seq_NSC_Mouse1.21458388
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20918679
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20826747
60* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20555409
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.20329189
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.19874534
63AR_19668381_ChIP-Seq_PC3_Human1.18700468
64FUS_26573619_Chip-Seq_HEK293_Human1.15248501
65* TCF4_23295773_ChIP-Seq_U87_Human1.14006189
66P53_22127205_ChIP-Seq_FIBROBLAST_Human1.13970317
67ARNT_22903824_ChIP-Seq_MCF-7_Human1.13793456
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08645447
69* PRDM14_20953172_ChIP-Seq_ESCs_Human1.07862754
70WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07667255
71RING1B_27294783_Chip-Seq_NPCs_Mouse1.06064015
72VDR_22108803_ChIP-Seq_LS180_Human1.05750589
73MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05748388
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05693650
75DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04892531
76AHR_22903824_ChIP-Seq_MCF-7_Human1.04031760
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03859241
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03076638
79* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02164947
80ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.01121759
81* RUNX2_22187159_ChIP-Seq_PCA_Human1.00532395
82CTCF_27219007_Chip-Seq_Bcells_Human1.00111689
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99271225
84JUN_21703547_ChIP-Seq_K562_Human0.96780724
85NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95795014
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95261099
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95261099
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94644564
89ER_23166858_ChIP-Seq_MCF-7_Human0.93944614
90RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93841826
91IGF1R_20145208_ChIP-Seq_DFB_Human0.93726905
92NANOG_18555785_Chip-Seq_ESCs_Mouse0.93496409
93FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93159101
94* SMAD3_21741376_ChIP-Seq_ESCs_Human0.93081729
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91525691
96LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90544337
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90501920
98* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.90087277
99CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89671787
100CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89616586
101VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.88911406
102SMAD3_21741376_ChIP-Seq_HESCs_Human0.88812455
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87323550
104SMAD4_21741376_ChIP-Seq_HESCs_Human0.87225808
105OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.86297767
106* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.84108623
107SOX9_26525672_Chip-Seq_HEART_Mouse0.83932462
108* SMAD4_21741376_ChIP-Seq_EPCs_Human0.82898106
109KDM2B_26808549_Chip-Seq_REH_Human0.82693474
110* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.81733269
111FLI1_21867929_ChIP-Seq_TH2_Mouse0.80682874
112SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.80277104

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.57396420
2MP0003880_abnormal_central_pattern5.35812117
3MP0003635_abnormal_synaptic_transmissio4.20643005
4MP0004270_analgesia3.53361433
5MP0009745_abnormal_behavioral_response3.50596310
6MP0002063_abnormal_learning/memory/cond3.41493330
7MP0002064_seizures3.26992785
8MP0009046_muscle_twitch3.12948602
9MP0001968_abnormal_touch/_nociception3.08926620
10MP0002572_abnormal_emotion/affect_behav2.89876928
11MP0002272_abnormal_nervous_system2.75543545
12MP0002822_catalepsy2.71579319
13MP0002734_abnormal_mechanical_nocicepti2.59826677
14MP0001486_abnormal_startle_reflex2.57208858
15MP0002736_abnormal_nociception_after2.53415876
16MP0002735_abnormal_chemical_nociception2.40483216
17MP0001501_abnormal_sleep_pattern2.31620088
18MP0005423_abnormal_somatic_nervous2.31182728
19MP0001440_abnormal_grooming_behavior2.30327454
20MP0002067_abnormal_sensory_capabilities2.05441646
21MP0009780_abnormal_chondrocyte_physiolo1.95788090
22MP0001970_abnormal_pain_threshold1.91715007
23MP0008569_lethality_at_weaning1.88724413
24MP0002733_abnormal_thermal_nociception1.87559888
25MP0003879_abnormal_hair_cell1.84540359
26MP0002184_abnormal_innervation1.82986380
27MP0005646_abnormal_pituitary_gland1.79954814
28MP0001984_abnormal_olfaction1.79425237
29MP0000778_abnormal_nervous_system1.75891162
30MP0002557_abnormal_social/conspecific_i1.71188864
31MP0004924_abnormal_behavior1.66421188
32MP0005386_behavior/neurological_phenoty1.66421188
33MP0003787_abnormal_imprinting1.64312795
34MP0004811_abnormal_neuron_physiology1.63882609
35MP0003329_amyloid_beta_deposits1.61579645
36MP0002909_abnormal_adrenal_gland1.59489106
37MP0006276_abnormal_autonomic_nervous1.55011130
38MP0004858_abnormal_nervous_system1.46941076
39MP0000955_abnormal_spinal_cord1.45803917
40MP0004885_abnormal_endolymph1.44024515
41MP0002882_abnormal_neuron_morphology1.42588368
42MP0001529_abnormal_vocalization1.42414320
43MP0002066_abnormal_motor_capabilities/c1.42068602
44MP0001905_abnormal_dopamine_level1.40549886
45MP0001502_abnormal_circadian_rhythm1.40335313
46MP0003283_abnormal_digestive_organ1.37424912
47MP0004142_abnormal_muscle_tone1.30973690
48MP0003633_abnormal_nervous_system1.30150260
49MP0001188_hyperpigmentation1.22627567
50MP0003123_paternal_imprinting1.21959460
51MP0005645_abnormal_hypothalamus_physiol1.21149777
52MP0004147_increased_porphyrin_level1.20191994
53MP0003122_maternal_imprinting1.18434460
54MP0003631_nervous_system_phenotype1.13602567
55MP0005551_abnormal_eye_electrophysiolog1.09660992
56MP0002152_abnormal_brain_morphology1.09236847
57MP0000569_abnormal_digit_pigmentation1.08031423
58MP0004742_abnormal_vestibular_system1.06317050
59MP0004145_abnormal_muscle_electrophysio1.04460656
60MP0010386_abnormal_urinary_bladder1.01600304
61MP0002229_neurodegeneration1.00958505
62MP0003121_genomic_imprinting1.00784997
63MP0002876_abnormal_thyroid_physiology0.97470949
64MP0001963_abnormal_hearing_physiology0.94983315
65MP0002069_abnormal_eating/drinking_beha0.92772451
66MP0001986_abnormal_taste_sensitivity0.92753481
67MP0008872_abnormal_physiological_respon0.92668195
68MP0002837_dystrophic_cardiac_calcinosis0.91549582
69MP0001485_abnormal_pinna_reflex0.89346126
70MP0003136_yellow_coat_color0.88489249
71MP0004085_abnormal_heartbeat0.86968646
72MP0005171_absent_coat_pigmentation0.86263944
73MP0000751_myopathy0.85462399
74MP0005394_taste/olfaction_phenotype0.84884846
75MP0005499_abnormal_olfactory_system0.84884846
76MP0008874_decreased_physiological_sensi0.83761092
77MP0004133_heterotaxia0.81679397
78MP0001177_atelectasis0.81632447
79MP0003632_abnormal_nervous_system0.81306235
80MP0002752_abnormal_somatic_nervous0.80510687
81MP0000013_abnormal_adipose_tissue0.79600317
82MP0004215_abnormal_myocardial_fiber0.78679073
83MP0005167_abnormal_blood-brain_barrier0.76571893
84MP0000631_abnormal_neuroendocrine_gland0.75818432
85MP0003634_abnormal_glial_cell0.75162216
86MP0003195_calcinosis0.74661640
87MP0004484_altered_response_of0.73679893
88MP0006292_abnormal_olfactory_placode0.73491395
89MP0005535_abnormal_body_temperature0.73168450
90MP0005253_abnormal_eye_physiology0.72553944
91MP0003646_muscle_fatigue0.72318683
92MP0002102_abnormal_ear_morphology0.70447001
93MP0000920_abnormal_myelination0.68736769
94MP0003075_altered_response_to0.66588466
95MP0001664_abnormal_digestion0.66103950
96MP0002090_abnormal_vision0.64510053
97MP0002638_abnormal_pupillary_reflex0.63946609
98MP0005379_endocrine/exocrine_gland_phen0.62855022
99MP0002653_abnormal_ependyma_morphology0.62362360
100MP0003938_abnormal_ear_development0.61981747
101MP0004043_abnormal_pH_regulation0.60726188
102MP0000604_amyloidosis0.60511584
103MP0000026_abnormal_inner_ear0.58966987
104MP0006072_abnormal_retinal_apoptosis0.57908811
105MP0004130_abnormal_muscle_cell0.57877080
106MP0003690_abnormal_glial_cell0.56942652
107MP0008877_abnormal_DNA_methylation0.56601954
108MP0001756_abnormal_urination0.56260245
109MP0003861_abnormal_nervous_system0.54807765
110MP0002928_abnormal_bile_duct0.54781158
111MP0003137_abnormal_impulse_conducting0.53684314
112MP0002163_abnormal_gland_morphology0.53399869
113MP0001943_abnormal_respiration0.52674006
114MP0003183_abnormal_peptide_metabolism0.52476910
115MP0010769_abnormal_survival0.51834181
116MP0010770_preweaning_lethality0.50768846
117MP0002082_postnatal_lethality0.50768846
118MP0005409_darkened_coat_color0.50153985
119MP0010768_mortality/aging0.49171259

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.65874265
2Myokymia (HP:0002411)6.80038652
3Focal seizures (HP:0007359)5.92381936
4Epileptic encephalopathy (HP:0200134)5.54641422
5Atonic seizures (HP:0010819)5.30979283
6Visual hallucinations (HP:0002367)5.28128361
7Febrile seizures (HP:0002373)5.11280752
8Absence seizures (HP:0002121)4.51258258
9Progressive cerebellar ataxia (HP:0002073)4.51089603
10Dialeptic seizures (HP:0011146)4.27627192
11Hyperventilation (HP:0002883)4.10439852
12Generalized tonic-clonic seizures (HP:0002069)3.92115156
13Broad-based gait (HP:0002136)3.80935421
14Action tremor (HP:0002345)3.78025207
15Gaze-evoked nystagmus (HP:0000640)3.65351704
16Amblyopia (HP:0000646)3.29991863
17Dysdiadochokinesis (HP:0002075)3.27252794
18Abnormality of the lower motor neuron (HP:0002366)3.26616746
19Poor eye contact (HP:0000817)3.25636931
20Impaired vibration sensation in the lower limbs (HP:0002166)3.23191486
21Dysmetria (HP:0001310)3.12197584
22Truncal ataxia (HP:0002078)3.04117484
23Depression (HP:0000716)2.95658809
24Ankle clonus (HP:0011448)2.95160503
25Supranuclear gaze palsy (HP:0000605)2.94246710
26Anxiety (HP:0000739)2.92538357
27Impaired social interactions (HP:0000735)2.85476841
28Abnormal social behavior (HP:0012433)2.85476841
29Abnormal eating behavior (HP:0100738)2.85033546
30Scanning speech (HP:0002168)2.84016443
31Urinary bladder sphincter dysfunction (HP:0002839)2.78886363
32Impaired smooth pursuit (HP:0007772)2.78637376
33Epileptiform EEG discharges (HP:0011182)2.76747944
34Genetic anticipation (HP:0003743)2.69643087
35Akinesia (HP:0002304)2.66134668
36Cerebral hypomyelination (HP:0006808)2.65323731
37Drooling (HP:0002307)2.60802882
38Excessive salivation (HP:0003781)2.60802882
39Hemiparesis (HP:0001269)2.55568515
40EEG with generalized epileptiform discharges (HP:0011198)2.52487811
41Postural instability (HP:0002172)2.42851875
42Spastic gait (HP:0002064)2.42664978
43Abnormality of ocular smooth pursuit (HP:0000617)2.38884366
44Dysmetric saccades (HP:0000641)2.38743648
45Stereotypic behavior (HP:0000733)2.37643657
46Absent speech (HP:0001344)2.34033060
47Hypsarrhythmia (HP:0002521)2.34011851
48Torticollis (HP:0000473)2.33297112
49Diplopia (HP:0000651)2.31645337
50Abnormality of binocular vision (HP:0011514)2.31645337
51Focal dystonia (HP:0004373)2.30510928
52Termporal pattern (HP:0011008)2.28272167
53Insidious onset (HP:0003587)2.28272167
54Urinary urgency (HP:0000012)2.27355726
55Bradykinesia (HP:0002067)2.27048581
56Intention tremor (HP:0002080)2.26834165
57Cerebral inclusion bodies (HP:0100314)2.24585519
58Pheochromocytoma (HP:0002666)2.23546047
59Impaired vibratory sensation (HP:0002495)2.23357817
60Gait imbalance (HP:0002141)2.20637373
61Progressive inability to walk (HP:0002505)2.19545904
62Fetal akinesia sequence (HP:0001989)2.16031079
63Annular pancreas (HP:0001734)2.14895822
64Hemiplegia (HP:0002301)2.13685977
65Mutism (HP:0002300)2.10600078
66Abnormality of the corticospinal tract (HP:0002492)2.10177470
67Status epilepticus (HP:0002133)2.09461904
68Delusions (HP:0000746)2.07615814
69Sleep apnea (HP:0010535)2.07514780
70Generalized myoclonic seizures (HP:0002123)2.06503072
71Incomplete penetrance (HP:0003829)2.03745094
72Lower limb muscle weakness (HP:0007340)2.03408131
73Morphological abnormality of the pyramidal tract (HP:0002062)2.02042677
74Congenital stationary night blindness (HP:0007642)2.01932118
75Inability to walk (HP:0002540)2.01536294
76Neurofibrillary tangles (HP:0002185)2.01452592
77Craniofacial dystonia (HP:0012179)2.00947457
78Gait ataxia (HP:0002066)2.00091605
79Hypomagnesemia (HP:0002917)1.99757143
80Blue irides (HP:0000635)1.98635122
81Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.98500014
82Polyphagia (HP:0002591)1.97571981
83Protruding tongue (HP:0010808)1.97385419
84Nephronophthisis (HP:0000090)1.94852293
85Congenital primary aphakia (HP:0007707)1.93896256
86Neuroendocrine neoplasm (HP:0100634)1.93407991
87CNS hypomyelination (HP:0003429)1.92579080
88Limb dystonia (HP:0002451)1.92439023
89Specific learning disability (HP:0001328)1.91414844
90Spastic tetraparesis (HP:0001285)1.88906577
91Tetraplegia (HP:0002445)1.87845504
92Increased circulating renin level (HP:0000848)1.87495046
93Spastic tetraplegia (HP:0002510)1.87440362
94Megalencephaly (HP:0001355)1.86696974
95Ventricular fibrillation (HP:0001663)1.86175277
96Medial flaring of the eyebrow (HP:0010747)1.85196828
97Clonus (HP:0002169)1.85030326
98Abnormality of midbrain morphology (HP:0002418)1.84181201
99Molar tooth sign on MRI (HP:0002419)1.84181201
100Abnormal drinking behavior (HP:0030082)1.83670227
101Polydipsia (HP:0001959)1.83670227
102Nephrogenic diabetes insipidus (HP:0009806)1.80947676
103Abnormality of salivation (HP:0100755)1.78766524
104Thickened helices (HP:0000391)1.76989684
105Papilledema (HP:0001085)1.75303655
106Psychosis (HP:0000709)1.74072485
107Agitation (HP:0000713)1.73760329
108Abnormality of saccadic eye movements (HP:0000570)1.73290848
109Retinal dysplasia (HP:0007973)1.73145926
110Type II lissencephaly (HP:0007260)1.71845022
111Degeneration of the lateral corticospinal tracts (HP:0002314)1.71301697
112Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.71301697
113Dynein arm defect of respiratory motile cilia (HP:0012255)1.71235186
114Absent/shortened dynein arms (HP:0200106)1.71235186
115Prolonged QT interval (HP:0001657)1.70059286
116Abnormality of macular pigmentation (HP:0008002)1.66364685
117Syncope (HP:0001279)1.66023681
118Abnormal EKG (HP:0003115)1.65179917
119Limb ataxia (HP:0002070)1.65177001
120Resting tremor (HP:0002322)1.63769587
121Pointed chin (HP:0000307)1.63687622
122Muscular hypotonia of the trunk (HP:0008936)1.63500973
123Abnormality of magnesium homeostasis (HP:0004921)1.61897393
124Rapidly progressive (HP:0003678)1.61515036
125Thyroid-stimulating hormone excess (HP:0002925)1.59068006
126Abnormality of the renal medulla (HP:0100957)1.58817199

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.84602278
2NTRK34.81592222
3MAP3K93.19273328
4CASK3.16016998
5MAP3K42.95216697
6DAPK22.68439423
7MAP2K72.66537197
8MINK12.46187602
9MAP3K122.06565661
10PRPF4B2.01078543
11MARK12.00335290
12KSR22.00240455
13PLK21.96103160
14PAK61.93805442
15FRK1.91229191
16DAPK11.89839496
17PRKD31.89342866
18NTRK21.86678733
19MAP2K41.86524658
20RIPK41.82926861
21KSR11.73461458
22ARAF1.65551143
23GRK51.59086912
24CAMKK11.58991533
25CDK191.57895851
26CDK51.44349074
27PNCK1.41914842
28NTRK11.31988743
29MAPK131.28587738
30PRKCG1.27200034
31PTK2B1.25147577
32TNIK1.24679130
33FES1.18719375
34SGK2231.18478933
35SGK4941.18478933
36BMPR21.16898374
37STK381.14899575
38CAMKK21.13589433
39AKT31.13536218
40CAMK2A1.11765993
41MAP3K131.11621125
42SIK31.09878284
43MAP3K21.06486159
44CAMK2B1.05850157
45BMPR1B1.04183818
46OXSR11.02213674
47ADRBK21.02208964
48SGK21.00958056
49CCNB10.98400979
50UHMK10.93752593
51CDK180.91260147
52SIK20.91151295
53CAMK10.90927721
54NME10.90022765
55INSRR0.87796393
56GRK10.87424272
57CDK150.84647527
58RAF10.84473017
59FGFR20.84195996
60MAP4K20.82575852
61CDK140.80378563
62PKN10.77601587
63DYRK20.76129770
64DYRK1A0.76023066
65TYRO30.74072190
66BRAF0.73457302
67LIMK10.73389583
68CDK11A0.73230028
69CAMK1G0.72715698
70PRKCH0.72437391
71SGK30.72182052
72PINK10.70624168
73STK110.70338115
74SGK10.70026012
75MAP2K60.70004183
76MARK20.67629026
77CAMK1D0.67320411
78WNK40.67095400
79BCKDK0.65649709
80LATS20.61453422
81TAOK10.61172651
82PRKCE0.60232693
83CAMK2D0.59531614
84FGR0.59508060
85PHKG10.57884139
86PHKG20.57884139
87PAK30.56788743
88BCR0.56452272
89ALK0.54517099
90PDK10.53993300
91RET0.52358609
92FER0.51003776
93CAMK2G0.50913791
94PDPK10.50372435
95MAP3K60.49819299
96MAP3K10.49722208
97CSNK1G20.49108489
98DAPK30.46515795
99MUSK0.45321251
100CSNK1G30.45059760
101RPS6KA30.44433765
102CAMK40.44206344
103TNK20.44180470
104CSNK1D0.43602832
105PRKG10.43225717
106CSNK1A10.41371646
107MAP2K10.41339985
108CSNK1G10.40565915
109PRKCZ0.39207403
110PRKG20.38980804
111CDC42BPA0.38104651
112NEK60.37997447
113WNK10.37588091
114MAPK100.35842899
115CSNK1E0.35334457
116WNK30.35137114
117MAPK120.35065554
118FYN0.34045400
119PRKAA10.33570123
120PRKACA0.33042189
121ADRBK10.32918145
122STK390.32864803
123ERBB20.31599632
124PRKCA0.30820594
125LMTK20.30500487
126MAP3K70.30290942

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.01882145
2Synaptic vesicle cycle_Homo sapiens_hsa047213.58997396
3Olfactory transduction_Homo sapiens_hsa047402.92544690
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.88763051
5Circadian entrainment_Homo sapiens_hsa047132.86814948
6Long-term potentiation_Homo sapiens_hsa047202.86486303
7GABAergic synapse_Homo sapiens_hsa047272.74098075
8Glutamatergic synapse_Homo sapiens_hsa047242.68066848
9Morphine addiction_Homo sapiens_hsa050322.63916920
10Amphetamine addiction_Homo sapiens_hsa050312.63101698
11Dopaminergic synapse_Homo sapiens_hsa047282.23116080
12Salivary secretion_Homo sapiens_hsa049702.21210391
13Insulin secretion_Homo sapiens_hsa049112.09642031
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.03915688
15Collecting duct acid secretion_Homo sapiens_hsa049662.02853978
16Taste transduction_Homo sapiens_hsa047421.93287860
17Cholinergic synapse_Homo sapiens_hsa047251.87800850
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.84624683
19Gastric acid secretion_Homo sapiens_hsa049711.83811670
20Long-term depression_Homo sapiens_hsa047301.78312225
21Serotonergic synapse_Homo sapiens_hsa047261.76902138
22Calcium signaling pathway_Homo sapiens_hsa040201.69414023
23Renin secretion_Homo sapiens_hsa049241.68615993
24Oxytocin signaling pathway_Homo sapiens_hsa049211.68545076
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59257940
26Cocaine addiction_Homo sapiens_hsa050301.53679171
27Butanoate metabolism_Homo sapiens_hsa006501.44219153
28GnRH signaling pathway_Homo sapiens_hsa049121.43666427
29Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33864041
30Vitamin B6 metabolism_Homo sapiens_hsa007501.33250225
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32115903
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.30230432
33cAMP signaling pathway_Homo sapiens_hsa040241.30021754
34Gap junction_Homo sapiens_hsa045401.23040261
35Vibrio cholerae infection_Homo sapiens_hsa051101.22925862
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20325507
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19103879
38Phototransduction_Homo sapiens_hsa047441.11743234
39Cardiac muscle contraction_Homo sapiens_hsa042601.11472478
40Type II diabetes mellitus_Homo sapiens_hsa049301.10014803
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07779693
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.04775589
43Estrogen signaling pathway_Homo sapiens_hsa049151.04686253
44Glioma_Homo sapiens_hsa052141.02061871
45Axon guidance_Homo sapiens_hsa043601.01859762
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.99670736
47Melanogenesis_Homo sapiens_hsa049160.98208799
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95810415
49ErbB signaling pathway_Homo sapiens_hsa040120.91227731
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91116903
51Oocyte meiosis_Homo sapiens_hsa041140.90146354
52Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87381129
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.87320921
54Pancreatic secretion_Homo sapiens_hsa049720.83071229
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82932055
56Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77771178
57Dorso-ventral axis formation_Homo sapiens_hsa043200.75544684
58Alzheimers disease_Homo sapiens_hsa050100.73941370
59Oxidative phosphorylation_Homo sapiens_hsa001900.71993030
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.71595834
61Circadian rhythm_Homo sapiens_hsa047100.68252000
62Thyroid hormone synthesis_Homo sapiens_hsa049180.67975864
63MAPK signaling pathway_Homo sapiens_hsa040100.66286554
64Choline metabolism in cancer_Homo sapiens_hsa052310.66046211
65Dilated cardiomyopathy_Homo sapiens_hsa054140.63733911
66beta-Alanine metabolism_Homo sapiens_hsa004100.62607719
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59987630
68Glucagon signaling pathway_Homo sapiens_hsa049220.58946279
69Histidine metabolism_Homo sapiens_hsa003400.58807965
70Arginine and proline metabolism_Homo sapiens_hsa003300.57516758
71Inositol phosphate metabolism_Homo sapiens_hsa005620.56535741
72Ras signaling pathway_Homo sapiens_hsa040140.55334035
73Linoleic acid metabolism_Homo sapiens_hsa005910.54923305
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53830749
75Type I diabetes mellitus_Homo sapiens_hsa049400.53700553
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51921787
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51536315
78Ether lipid metabolism_Homo sapiens_hsa005650.50171260
79Alcoholism_Homo sapiens_hsa050340.50158417
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.48777522
81Mineral absorption_Homo sapiens_hsa049780.48412399
82Rap1 signaling pathway_Homo sapiens_hsa040150.48198712
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47435424
84VEGF signaling pathway_Homo sapiens_hsa043700.46548199
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45718267
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45469972
87Parkinsons disease_Homo sapiens_hsa050120.44526779
88ABC transporters_Homo sapiens_hsa020100.42588048
89Nitrogen metabolism_Homo sapiens_hsa009100.41730593
90Tryptophan metabolism_Homo sapiens_hsa003800.41187139
91Wnt signaling pathway_Homo sapiens_hsa043100.39633168
92Regulation of autophagy_Homo sapiens_hsa041400.39334424
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39257725
94Ovarian steroidogenesis_Homo sapiens_hsa049130.38846100
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38710263
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38481932
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.38425216
98Endocytosis_Homo sapiens_hsa041440.38132624
99Rheumatoid arthritis_Homo sapiens_hsa053230.36626626
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36558970
101Primary bile acid biosynthesis_Homo sapiens_hsa001200.35711046
102Huntingtons disease_Homo sapiens_hsa050160.35573155
103Tight junction_Homo sapiens_hsa045300.35027798
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33767772
105African trypanosomiasis_Homo sapiens_hsa051430.33703013
106mTOR signaling pathway_Homo sapiens_hsa041500.32047301
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31833405
108Fatty acid biosynthesis_Homo sapiens_hsa000610.29369110
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29204578
110Prion diseases_Homo sapiens_hsa050200.28822783
111Arginine biosynthesis_Homo sapiens_hsa002200.28775991
112Bile secretion_Homo sapiens_hsa049760.28204728
113Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27146768
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26509211
115Renal cell carcinoma_Homo sapiens_hsa052110.26461229
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25903782
117Non-small cell lung cancer_Homo sapiens_hsa052230.25116278
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.24942302
119Insulin signaling pathway_Homo sapiens_hsa049100.24732082
120Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23113119

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