PGC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial structure maintenance (GO:0010669)9.96159277
2surfactant homeostasis (GO:0043129)9.94433496
3intestinal cholesterol absorption (GO:0030299)8.20067165
4chemical homeostasis within a tissue (GO:0048875)7.95381935
5neutrophil mediated immunity (GO:0002446)7.90577660
6* digestion (GO:0007586)7.90200603
7pH reduction (GO:0045851)7.45983830
8extracellular fibril organization (GO:0043206)7.34492872
9phosphatidylserine acyl-chain remodeling (GO:0036150)6.90570368
10leukotriene biosynthetic process (GO:0019370)6.60419992
11digestive system process (GO:0022600)6.57423401
12protein autoprocessing (GO:0016540)6.54844558
13arachidonic acid secretion (GO:0050482)6.44953873
14icosanoid secretion (GO:0032309)6.44953873
15cobalamin metabolic process (GO:0009235)6.40641349
16sulfation (GO:0051923)6.39357227
17phosphatidylinositol acyl-chain remodeling (GO:0036149)6.27069237
18negative regulation of fibrinolysis (GO:0051918)6.26109060
19regulation of complement activation (GO:0030449)6.25896396
20fibril organization (GO:0097435)6.22307406
21regulation of protein activation cascade (GO:2000257)6.19672336
22glutathione derivative metabolic process (GO:1901685)6.18464973
23glutathione derivative biosynthetic process (GO:1901687)6.18464973
24myeloid leukocyte mediated immunity (GO:0002444)6.17846050
25very-low-density lipoprotein particle assembly (GO:0034379)6.01432794
26phosphatidylglycerol acyl-chain remodeling (GO:0036148)6.00855926
27O-glycan processing (GO:0016266)5.95903270
28fatty acid derivative transport (GO:1901571)5.84792257
29icosanoid transport (GO:0071715)5.84792257
30regulation of apoptotic cell clearance (GO:2000425)5.76141753
31regulation of pH (GO:0006885)5.73824630
32negative regulation of protein activation cascade (GO:2000258)5.71251245
33low-density lipoprotein particle remodeling (GO:0034374)5.66558944
34protein retention in ER lumen (GO:0006621)5.48329986
35complement activation, classical pathway (GO:0006958)5.44187549
36leukotriene metabolic process (GO:0006691)5.38623702
37plasma lipoprotein particle assembly (GO:0034377)5.37470234
38growth hormone secretion (GO:0030252)5.37356529
39negative regulation of complement activation (GO:0045916)5.34348740
40antibacterial humoral response (GO:0019731)5.28615385
41phosphatidylserine metabolic process (GO:0006658)5.27851686
42intestinal absorption (GO:0050892)5.26667769
43purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.26516819
443-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.26516819
45regulation of fibrinolysis (GO:0051917)5.13529026
46innate immune response in mucosa (GO:0002227)5.11998357
47vitamin transport (GO:0051180)5.09565969
48maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.05172568
49daunorubicin metabolic process (GO:0044597)5.01136369
50polyketide metabolic process (GO:0030638)5.01136369
51doxorubicin metabolic process (GO:0044598)5.01136369
52antimicrobial humoral response (GO:0019730)4.96311995
53complement activation (GO:0006956)4.94177232
54ATP hydrolysis coupled proton transport (GO:0015991)4.91050241
55energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.91050241
56phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.89702713
57protein activation cascade (GO:0072376)4.86595960
58protein-lipid complex assembly (GO:0065005)4.80043253
59positive regulation of growth hormone secretion (GO:0060124)4.75882714
60acid secretion (GO:0046717)4.74956800
61peptidyl-glutamic acid carboxylation (GO:0017187)4.73712566
62protein carboxylation (GO:0018214)4.73712566
63regulation of cholesterol homeostasis (GO:2000188)4.71581394
64regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.58331565
65thyroid hormone metabolic process (GO:0042403)4.57132276
66regulation of cholesterol esterification (GO:0010872)4.46942776
67blood coagulation, intrinsic pathway (GO:0007597)4.46044684
68diacylglycerol metabolic process (GO:0046339)4.42373882
69thyroid hormone generation (GO:0006590)4.42326213
70plasma lipoprotein particle remodeling (GO:0034369)4.41442041
71protein-lipid complex remodeling (GO:0034368)4.41442041
72macromolecular complex remodeling (GO:0034367)4.41442041
73aminoglycoside antibiotic metabolic process (GO:0030647)4.40791381
74bundle of His cell to Purkinje myocyte communication (GO:0086069)4.33564746
75peptidyl-proline hydroxylation (GO:0019511)4.32923598
76protein O-linked glycosylation (GO:0006493)4.32685695
77low-density lipoprotein particle clearance (GO:0034383)4.28484361
78negative regulation of humoral immune response (GO:0002921)4.25739162
79negative regulation of interleukin-1 beta production (GO:0032691)4.25621113
80alditol phosphate metabolic process (GO:0052646)4.24639794
81plasma lipoprotein particle organization (GO:0071827)4.23284362
82cholesterol efflux (GO:0033344)4.20208322
83mucosal immune response (GO:0002385)4.12856028
84ATP biosynthetic process (GO:0006754)4.09973458
85plasma lipoprotein particle clearance (GO:0034381)4.09368837
86positive regulation of extracellular matrix organization (GO:1903055)4.06476154
87protein-lipid complex subunit organization (GO:0071825)3.98880910
88negative regulation of interleukin-1 production (GO:0032692)3.97702153
89response to iron ion (GO:0010039)3.94689926
90progesterone metabolic process (GO:0042448)3.92192460
91ethanol oxidation (GO:0006069)3.90241868
92organ or tissue specific immune response (GO:0002251)3.89613717
93hydrogen ion transmembrane transport (GO:1902600)3.87800281
94negative regulation of digestive system process (GO:0060457)3.80914653
95trivalent inorganic anion homeostasis (GO:0072506)3.80220878
96phosphate ion homeostasis (GO:0055062)3.80220878
97positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.78550909
98monovalent inorganic cation homeostasis (GO:0055067)3.75249940
99complement activation, alternative pathway (GO:0006957)3.75081262
100phosphatidylcholine acyl-chain remodeling (GO:0036151)3.73550728
101regulation of plasminogen activation (GO:0010755)3.73273725
102retinal metabolic process (GO:0042574)3.71510513
103regulation of humoral immune response (GO:0002920)3.66404842
104ventricular cardiac muscle cell action potential (GO:0086005)3.65967573
105erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.62841453
106L-phenylalanine metabolic process (GO:0006558)3.62841453
107phospholipid scrambling (GO:0017121)3.62279169
108erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.59283690
109L-phenylalanine catabolic process (GO:0006559)3.59283690
110regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.57591827
111C21-steroid hormone metabolic process (GO:0008207)3.53148300
112cellular response to nitric oxide (GO:0071732)3.51833493
113phosphatidic acid biosynthetic process (GO:0006654)3.51395985
114phosphatidic acid metabolic process (GO:0046473)3.51395985
115L-fucose metabolic process (GO:0042354)3.48901453
116L-fucose catabolic process (GO:0042355)3.48901453
117fucose catabolic process (GO:0019317)3.48901453
118sterol transport (GO:0015918)3.48328608
119cholesterol transport (GO:0030301)3.48328608
120valine metabolic process (GO:0006573)3.44914343
121protein hydroxylation (GO:0018126)3.43189106
122adult feeding behavior (GO:0008343)3.41404574
123regulation of growth hormone secretion (GO:0060123)3.40791635
124cholesterol homeostasis (GO:0042632)3.40461897
125renal absorption (GO:0070293)3.39144026
126regulation of extracellular matrix organization (GO:1903053)3.38786362
127high-density lipoprotein particle remodeling (GO:0034375)3.38452747
128regulation of bile acid biosynthetic process (GO:0070857)3.37392375
129sterol homeostasis (GO:0055092)3.37329553
130lipoprotein metabolic process (GO:0042157)3.35166414
131renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.34075767
132ethanol metabolic process (GO:0006067)3.32315328
133positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.30297962
134negative regulation of sterol transport (GO:0032372)3.30133439
135negative regulation of cholesterol transport (GO:0032375)3.30133439
136regulation of glucocorticoid secretion (GO:2000849)3.28078162
137proton transport (GO:0015992)3.27307447
138sodium ion export (GO:0071436)3.26063525
139endocrine hormone secretion (GO:0060986)3.24552510
140positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.24515921
141hydrogen transport (GO:0006818)3.22389642
142triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.21581118
143branched-chain amino acid catabolic process (GO:0009083)3.20488352
144acute-phase response (GO:0006953)3.17805862
145sulfur amino acid catabolic process (GO:0000098)3.16988996
146cellular response to gonadotropin stimulus (GO:0071371)3.15262247
147xenobiotic metabolic process (GO:0006805)3.12884468
148cellular anion homeostasis (GO:0030002)3.12077562
149positive regulation of phagocytosis (GO:0050766)3.11537607
150pinocytosis (GO:0006907)3.10531572
151glutathione metabolic process (GO:0006749)3.09520496
152positive regulation of chemokine secretion (GO:0090197)3.08366970
153phosphatidylglycerol metabolic process (GO:0046471)3.07403280
154reverse cholesterol transport (GO:0043691)3.06229018
155production of molecular mediator of immune response (GO:0002440)3.06068502
156peptide catabolic process (GO:0043171)3.05233841
157positive regulation of hemostasis (GO:1900048)3.04267209
158positive regulation of blood coagulation (GO:0030194)3.04267209
159glandular epithelial cell differentiation (GO:0002067)3.03096960
160regulation of cholesterol biosynthetic process (GO:0045540)3.01033839
161cellular response to reactive nitrogen species (GO:1902170)2.95358930
162regulation of heart rate by cardiac conduction (GO:0086091)2.94280366
163purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.93583003
164cellular response to arsenic-containing substance (GO:0071243)2.93352043
165long-chain fatty acid transport (GO:0015909)2.93105793
166kidney morphogenesis (GO:0060993)2.91961419
167membrane repolarization during action potential (GO:0086011)2.91289916
168positive regulation of fatty acid biosynthetic process (GO:0045723)2.90105435
169regulation of transforming growth factor beta1 production (GO:0032908)2.89596937
170bicarbonate transport (GO:0015701)2.89394697
171intestinal epithelial cell development (GO:0060576)2.89364672
172positive regulation of triglyceride lipase activity (GO:0061365)2.88551784
173positive regulation of lipoprotein lipase activity (GO:0051006)2.88551784
174purine nucleoside triphosphate biosynthetic process (GO:0009145)2.88510435
175glycerol metabolic process (GO:0006071)2.88459519
176negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.88100866
177transepithelial transport (GO:0070633)2.87557750
178response to vitamin A (GO:0033189)2.87065436
179cellular hyperosmotic response (GO:0071474)2.85953830
180L-serine transport (GO:0015825)2.85625124
181regulation of skeletal muscle contraction (GO:0014819)2.85342216
182positive regulation of coagulation (GO:0050820)2.83634171
183regulation of cholesterol storage (GO:0010885)2.82865914
184regulation of cholesterol metabolic process (GO:0090181)2.81130892
185negative regulation of hemostasis (GO:1900047)2.80941894
186negative regulation of blood coagulation (GO:0030195)2.80941894
187lung secretory cell differentiation (GO:0061140)2.80697378
188response to prostaglandin (GO:0034694)2.80286371
189positive regulation of lipid storage (GO:0010884)2.80061908
190regulation of chemokine secretion (GO:0090196)2.79930021
191cell proliferation involved in metanephros development (GO:0072203)2.76652242
192lipid homeostasis (GO:0055088)2.74275398
193positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.72960384
194regulation of metalloenzyme activity (GO:0048552)2.71331363
195maintenance of gastrointestinal epithelium (GO:0030277)13.0825536
196regulation of phospholipase A2 activity (GO:0032429)11.6099239
197regulation of proton transport (GO:0010155)11.4038111

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_15608294_ChIP-ChIP_MCF-7_Human5.59321420
2IGF1R_20145208_ChIP-Seq_DFB_Human5.36104438
3SOX2_27498859_Chip-Seq_STOMACH_Mouse5.22496627
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.71047754
5SRY_22984422_ChIP-ChIP_TESTIS_Rat3.23859689
6ESR2_21235772_ChIP-Seq_MCF-7_Human3.22709526
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.19052401
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.19052401
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.19052401
10ESR1_21235772_ChIP-Seq_MCF-7_Human3.18506168
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.02393250
12ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.00733192
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.99011527
14GATA4_25053715_ChIP-Seq_YYC3_Human2.75251248
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.66327619
16CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.51042083
17TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.40480637
18CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.39065377
19TCF4_18268006_ChIP-ChIP_LS174T_Human2.37571269
20* HNF4A_19822575_ChIP-Seq_HepG2_Human2.19843925
21LXR_22292898_ChIP-Seq_THP-1_Human2.06023012
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.05873694
23GATA6_25053715_ChIP-Seq_YYC3_Human2.05598767
24SOX2_20726797_ChIP-Seq_SW620_Human2.00049669
25PPARA_22158963_ChIP-Seq_LIVER_Mouse1.98952960
26AHR_22903824_ChIP-Seq_MCF-7_Human1.98039608
27ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.97686453
28CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.96989608
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.94638913
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.93413788
31HIF1A_21447827_ChIP-Seq_MCF-7_Human1.91211165
32AR_21572438_ChIP-Seq_LNCaP_Human1.86427266
33* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.86098540
34RXR_22158963_ChIP-Seq_LIVER_Mouse1.83942603
35LXR_22158963_ChIP-Seq_LIVER_Mouse1.83483089
36NFIB_24661679_ChIP-Seq_LUNG_Mouse1.82559734
37EGR1_23403033_ChIP-Seq_LIVER_Mouse1.63604248
38VDR_22108803_ChIP-Seq_LS180_Human1.58064193
39ESR1_20079471_ChIP-ChIP_T-47D_Human1.57488309
40STAT1_20625510_ChIP-Seq_HELA_Human1.54402362
41* KLF5_25053715_ChIP-Seq_YYC3_Human1.54104439
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.53356933
43AR_21909140_ChIP-Seq_LNCAP_Human1.53228444
44* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.52576726
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.45191891
46KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.44025831
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43284366
48FOXO3_23340844_ChIP-Seq_DLD1_Human1.40669776
49EP300_21415370_ChIP-Seq_HL-1_Mouse1.40128118
50* EGR1_19032775_ChIP-ChIP_M12_Human1.36341365
51CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.34688731
52RACK7_27058665_Chip-Seq_MCF-7_Human1.33868173
53TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33742112
54CTNNB1_20460455_ChIP-Seq_HCT116_Human1.31480702
55TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29177195
56FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.28023168
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.27470909
58SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.26855868
59TRIM28_21343339_ChIP-Seq_HEK293_Human1.25665175
60NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.25336789
61ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.24627125
62CDX2_20551321_ChIP-Seq_CACO-2_Human1.24490342
63RUNX1_27514584_Chip-Seq_MCF-7_Human1.22630605
64* GATA3_24758297_ChIP-Seq_MCF-7_Human1.19837530
65BCAT_22108803_ChIP-Seq_LS180_Human1.19177597
66KDM2B_26808549_Chip-Seq_K562_Human1.18751592
67SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18424618
68Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.17453208
69P63_26484246_Chip-Seq_KERATINOCYTES_Human1.17346971
70FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.17230539
71* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.17014871
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14709996
73ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14252179
74KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13371792
75BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12877030
76STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.12575454
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12495137
78* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.12186420
79BCOR_27268052_Chip-Seq_Bcells_Human1.11087671
80SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.07681136
81ZNF263_19887448_ChIP-Seq_K562_Human1.06963699
82* FOXA2_19822575_ChIP-Seq_HepG2_Human1.06700077
83ZNF274_21170338_ChIP-Seq_K562_Hela1.05874928
84NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.05236049
85HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.04616917
86DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03498489
87ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.02872352
88CLOCK_20551151_ChIP-Seq_293T_Human1.00844556
89RXR_22108803_ChIP-Seq_LS180_Human1.00294013
90PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98644052
91SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96401770
92SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95706802
93SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95706802
94GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94025531
95CREB1_26743006_Chip-Seq_LNCaP_Human0.93165803
96GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92209242
97GATA2_21666600_ChIP-Seq_HMVEC_Human0.91691351
98TBX20_22080862_ChIP-Seq_HEART_Mouse0.91222512
99TBX20_22328084_ChIP-Seq_HEART_Mouse0.91222512
100BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.91201988
101FOXA1_25552417_ChIP-Seq_VCAP_Human0.90706538
102SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.90284421
103NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88764705
104ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87193228
105CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86667501
106SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86544492
107NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.86379573
108TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.86344545
109ATF3_27146783_Chip-Seq_COLON_Human0.86005006
110IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.85826006
111WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85415552
112EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.85325430
113TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85131626
114CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84770301
115SALL4_18804426_ChIP-ChIP_XEN_Mouse0.84329740
116JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84249506
117* GATA1_19941827_ChIP-Seq_MEL_Mouse0.82498091
118SA1_27219007_Chip-Seq_ERYTHROID_Human0.82450908
119SMAD3_21741376_ChIP-Seq_HESCs_Human0.82072463
120JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81211440
121FOXM1_26456572_ChIP-Seq_MCF-7_Human0.80635024
122RAD21_21589869_ChIP-Seq_MESCs_Mouse0.79953411
123EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.79720332
124TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.79520980
125* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.78829365
126P300_27058665_Chip-Seq_ZR-75-30cells_Human0.78762656
127FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.78584032
128CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78305565
129SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.78204131
130GATA1_19941826_ChIP-Seq_K562_Human0.77890526
131POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.77860893
132SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.77547693
133CJUN_26792858_Chip-Seq_BT549_Human0.77314802
134CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77108285
135PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.76380064
136NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.76145006
137HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.75851611
138RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.74276271
139NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.73698027
140PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.73142445
141ERG_21242973_ChIP-ChIP_JURKAT_Human0.73109481
142RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.71688371
143STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.71339133
144CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.69595331

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004782_abnormal_surfactant_physiolog6.01092835
2MP0001664_abnormal_digestion5.06126743
3MP0000470_abnormal_stomach_morphology4.35184672
4MP0001873_stomach_inflammation4.09955610
5MP0001666_abnormal_nutrient_absorption3.73457751
6MP0001958_emphysema3.52332832
7MP0003122_maternal_imprinting3.35752484
8MP0003806_abnormal_nucleotide_metabolis3.04882221
9MP0003195_calcinosis2.60135273
10MP0005083_abnormal_biliary_tract2.38041281
11MP0005058_abnormal_lysosome_morphology2.34674181
12MP0003868_abnormal_feces_composition2.23089762
13MP0002089_abnormal_postnatal_growth/wei2.18207647
14MP0010368_abnormal_lymphatic_system2.05328977
15MP0004272_abnormal_basement_membrane2.04506044
16MP0008004_abnormal_stomach_pH17.6576236
17MP0005167_abnormal_blood-brain_barrier1.83743154
18MP0005451_abnormal_body_composition1.83097969
19MP0005164_abnormal_response_to1.72239503
20MP0002133_abnormal_respiratory_system1.67289991
21MP0005388_respiratory_system_phenotype1.67289991
22MP0005409_darkened_coat_color1.66861850
23MP0004883_abnormal_blood_vessel1.58675293
24MP0003123_paternal_imprinting1.58277439
25MP0005165_increased_susceptibility_to1.58106615
26MP0001663_abnormal_digestive_system1.55757085
27MP0000566_synostosis1.54301998
28MP0010234_abnormal_vibrissa_follicle1.51981355
29MP0008995_early_reproductive_senescence1.49826606
30MP0005085_abnormal_gallbladder_physiolo1.49031331
31MP0003950_abnormal_plasma_membrane1.40172391
32MP0005381_digestive/alimentary_phenotyp1.39307641
33MP0003172_abnormal_lysosome_physiology1.33817917
34MP0001915_intracranial_hemorrhage1.31534373
35MP0002295_abnormal_pulmonary_circulatio1.22938666
36MP0003115_abnormal_respiratory_system1.21364881
37MP0001661_extended_life_span1.18528789
38MP0002132_abnormal_respiratory_system1.17803157
39MP0002971_abnormal_brown_adipose1.14511982
40MP0003091_abnormal_cell_migration1.13397183
41MP0002933_joint_inflammation1.13033811
42MP0001177_atelectasis1.09610037
43MP0010329_abnormal_lipoprotein_level1.09040240
44MP0002909_abnormal_adrenal_gland1.04057536
45MP0004264_abnormal_extraembryonic_tissu1.03526165
46MP0005076_abnormal_cell_differentiation1.03461093
47MP0006138_congestive_heart_failure1.01980368
48MP0000249_abnormal_blood_vessel1.01232658
49MP0006054_spinal_hemorrhage1.00880639
50MP0002166_altered_tumor_susceptibility1.00213891
51MP0005023_abnormal_wound_healing0.99440473
52MP0008875_abnormal_xenobiotic_pharmacok0.98273629
53MP0005365_abnormal_bile_salt0.97190204
54MP0000477_abnormal_intestine_morphology0.97134715
55MP0001851_eye_inflammation0.95824810
56MP0003724_increased_susceptibility_to0.95079751
57MP0003705_abnormal_hypodermis_morpholog0.87155016
58MP0002998_abnormal_bone_remodeling0.85926869
59MP0003186_abnormal_redox_activity0.84163525
60MP0005464_abnormal_platelet_physiology0.82035952
61MP0009115_abnormal_fat_cell0.81623766
62MP0001175_abnormal_lung_morphology0.80791543
63MP0001270_distended_abdomen0.78786267
64MP0003283_abnormal_digestive_organ0.78587491
65MP0005266_abnormal_metabolism0.77374950
66MP0003890_abnormal_embryonic-extraembry0.77093770
67MP0009384_cardiac_valve_regurgitation0.76656171
68MP0000767_abnormal_smooth_muscle0.75025367
69MP0005448_abnormal_energy_balance0.72451888
70MP0003941_abnormal_skin_development0.72438344
71MP0005666_abnormal_adipose_tissue0.71125029
72MP0000462_abnormal_digestive_system0.70294492
73MP0001542_abnormal_bone_strength0.70239268
74MP0002118_abnormal_lipid_homeostasis0.66380203
75MP0002128_abnormal_blood_circulation0.65469763
76MP0008469_abnormal_protein_level0.65359695
77MP0002876_abnormal_thyroid_physiology0.65312932
78MP0003436_decreased_susceptibility_to0.65237838
79MP0000003_abnormal_adipose_tissue0.63573594
80MP0005084_abnormal_gallbladder_morpholo0.63501776
81MP0003942_abnormal_urinary_system0.63288192
82MP0002837_dystrophic_cardiac_calcinosis0.62854485
83MP0005670_abnormal_white_adipose0.62672570
84MP0000467_abnormal_esophagus_morphology0.61507294
85MP0005257_abnormal_intraocular_pressure0.61345633
86MP0004484_altered_response_of0.60360509
87MP0000537_abnormal_urethra_morphology0.59325672
88MP0003953_abnormal_hormone_level0.58197660
89MP0002139_abnormal_hepatobiliary_system0.58056071
90MP0003075_altered_response_to0.57369288
91MP0004185_abnormal_adipocyte_glucose0.57257243
92MP0002970_abnormal_white_adipose0.53123176
93MP0000490_abnormal_crypts_of0.50710693
94MP0003191_abnormal_cellular_cholesterol0.49578652
95MP0002796_impaired_skin_barrier0.48655937
96MP0005452_abnormal_adipose_tissue0.47744938
97MP0004858_abnormal_nervous_system0.47177997
98MP0001243_abnormal_dermal_layer0.46998675
99MP0004130_abnormal_muscle_cell0.42797607
100MP0003566_abnormal_cell_adhesion0.41216545
101MP0002078_abnormal_glucose_homeostasis0.41040684
102MP0005334_abnormal_fat_pad0.39886093
103MP0010155_abnormal_intestine_physiology0.39043490
104MP0005166_decreased_susceptibility_to0.38649832
105MP0005360_urolithiasis0.35597156
106MP0009642_abnormal_blood_homeostasis0.35244284
107MP0003329_amyloid_beta_deposits0.35053801
108MP0004947_skin_inflammation0.33841891
109MP0005319_abnormal_enzyme/_coenzyme0.33211431
110MP0004859_abnormal_synaptic_plasticity0.31902148
111MP0005376_homeostasis/metabolism_phenot0.30467221
112MP0003252_abnormal_bile_duct0.29699044
113MP0005584_abnormal_enzyme/coenzyme_acti0.29257037
114MP0004043_abnormal_pH_regulation0.28591448
115MP0008770_decreased_survivor_rate0.27320873
116MP0000598_abnormal_liver_morphology0.27076750
117MP0003866_abnormal_defecation0.26968275
118MP0000367_abnormal_coat/_hair0.26918537
119MP0000013_abnormal_adipose_tissue0.26063444
120MP0008438_abnormal_cutaneous_collagen0.25904443
121MP0009780_abnormal_chondrocyte_physiolo0.25449316
122MP0010352_gastrointestinal_tract_polyps0.23542092
123MP0003690_abnormal_glial_cell0.23057050
124MP0002234_abnormal_pharynx_morphology0.22983983
125MP0003656_abnormal_erythrocyte_physiolo0.22456664
126MP0004019_abnormal_vitamin_homeostasis0.22293061
127MP0005332_abnormal_amino_acid0.22031702
128MP0001756_abnormal_urination0.21868548
129MP0001216_abnormal_epidermal_layer0.21623574
130MP0000609_abnormal_liver_physiology0.21437044
131MP0002060_abnormal_skin_morphology0.21292414
132MP0009643_abnormal_urine_homeostasis0.20539164
133MP0001440_abnormal_grooming_behavior0.20092728
134MP0002069_abnormal_eating/drinking_beha0.19692872
135MP0001849_ear_inflammation0.19582217
136MP0005310_abnormal_salivary_gland0.18606774
137MP0002877_abnormal_melanocyte_morpholog0.18112085
138MP0000604_amyloidosis0.17983365
139MP0000465_gastrointestinal_hemorrhage0.17449436
140MP0002693_abnormal_pancreas_physiology0.16671072
141MP0005408_hypopigmentation0.16497697
142MP0003221_abnormal_cardiomyocyte_apopto0.16452407
143MP0003119_abnormal_digestive_system0.16278610
144MP0002972_abnormal_cardiac_muscle0.15762821
145MP0009840_abnormal_foam_cell0.15756686
146MP0010678_abnormal_skin_adnexa0.15719250
147MP0001845_abnormal_inflammatory_respons0.15457786
148MP0005636_abnormal_mineral_homeostasis0.15443160
149MP0002019_abnormal_tumor_incidence0.14706547
150MP0003638_abnormal_response/metabolism_0.14608835
151MP0000343_altered_response_to0.14490933
152MP0003453_abnormal_keratinocyte_physiol0.14125251
153MP0005220_abnormal_exocrine_pancreas0.13699798
154MP0005501_abnormal_skin_physiology0.13683387
155MP0009931_abnormal_skin_appearance0.13393002
156MP0005275_abnormal_skin_tensile0.13054391

Predicted human phenotypes

RankGene SetZ-score
1Megaloblastic anemia (HP:0001889)9.15216531
2Abnormality of the vitamin B12 metabolism (HP:0004341)8.78383715
3Abnormality of vitamin B metabolism (HP:0004340)8.28503536
4Interstitial pulmonary disease (HP:0006530)7.89280336
5Abnormality of vitamin metabolism (HP:0100508)6.81819901
6Complement deficiency (HP:0004431)6.52454089
7Systemic lupus erythematosus (HP:0002725)6.21376032
8Glomerulonephritis (HP:0000099)6.09462285
9Right ventricular cardiomyopathy (HP:0011663)5.83348255
10Abnormality of complement system (HP:0005339)5.29852538
11Joint hemorrhage (HP:0005261)5.04206074
12Prolonged partial thromboplastin time (HP:0003645)4.83601592
13Gout (HP:0001997)4.78622425
14Abnormality of the common coagulation pathway (HP:0010990)4.11367270
15Ventricular fibrillation (HP:0001663)3.92791618
16Hypobetalipoproteinemia (HP:0003563)3.77128028
17Goiter (HP:0000853)3.69668253
18Abnormal tarsal ossification (HP:0008369)3.52025526
19Macrocytic anemia (HP:0001972)3.50771281
20Nephritis (HP:0000123)3.47426019
21Abnormality of carpal bone ossification (HP:0006257)3.46561572
22Hypercholesterolemia (HP:0003124)3.36120233
23Syncope (HP:0001279)3.35158153
24Tachypnea (HP:0002789)3.21673678
25Small epiphyses (HP:0010585)3.21223456
26Abnormality of the lumbar spine (HP:0100712)3.18597252
27Purpura (HP:0000979)3.16176184
28Mitral stenosis (HP:0001718)3.15339468
29Epidermoid cyst (HP:0200040)3.12367878
30Menorrhagia (HP:0000132)3.08064009
31Spontaneous abortion (HP:0005268)2.94193186
32Myocardial infarction (HP:0001658)2.83269205
33Paresthesia (HP:0003401)2.81937024
34Protrusio acetabuli (HP:0003179)2.72250866
35Hypolipoproteinemia (HP:0010981)2.69986341
36Increased purine levels (HP:0004368)2.67728579
37Hyperuricemia (HP:0002149)2.67728579
38Respiratory distress (HP:0002098)2.65961565
39Palpitations (HP:0001962)2.65128115
40Abnormal ossification of hand bones (HP:0005921)2.62712150
41Acanthocytosis (HP:0001927)2.58760316
42Aortic dissection (HP:0002647)2.58299816
43Fat malabsorption (HP:0002630)2.56943255
44Broad alveolar ridges (HP:0000187)2.56863963
45Abnormal hand bone ossification (HP:0010660)2.54786614
46Ketoacidosis (HP:0001993)2.52522774
47Tubulointerstitial nephritis (HP:0001970)2.50464141
48Malnutrition (HP:0004395)2.46613815
49Broad palm (HP:0001169)2.43804871
50Intrahepatic cholestasis (HP:0001406)2.40056093
51Beaking of vertebral bodies (HP:0004568)2.36648912
52Ketosis (HP:0001946)2.36586118
53Abnormality of purine metabolism (HP:0004352)2.35816576
54Epiphyseal dysplasia (HP:0002656)2.35435850
55Ventricular arrhythmia (HP:0004308)2.30890742
56Abnormal foot bone ossification (HP:0010675)2.30699647
57Urinary glycosaminoglycan excretion (HP:0003541)2.28189251
58Mucopolysacchariduria (HP:0008155)2.28189251
59Cerebral aneurysm (HP:0004944)2.25678608
60Neoplasm of the heart (HP:0100544)2.22283166
61Aortic aneurysm (HP:0004942)2.22108945
62Esophageal varix (HP:0002040)2.21056296
63Woolly hair (HP:0002224)2.20486740
64Flared iliac wings (HP:0002869)2.20024657
65Polycythemia (HP:0001901)2.19600166
66Glomerulosclerosis (HP:0000096)2.19501359
67Gingival bleeding (HP:0000225)2.16332500
68Potter facies (HP:0002009)2.12105008
69Facial shape deformation (HP:0011334)2.12105008
70Renal salt wasting (HP:0000127)2.12104597
71Arterial tortuosity (HP:0005116)2.08052841
72Recurrent gram-negative bacterial infections (HP:0005420)2.07881813
73Tubulointerstitial fibrosis (HP:0005576)2.06551464
74Thrombophlebitis (HP:0004418)2.04551838
75Prolonged QT interval (HP:0001657)2.01799003
76Abnormality of the acetabulum (HP:0003170)2.01769722
77Segmental peripheral demyelination/remyelination (HP:0003481)2.01626933
78Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.01449605
79Asymmetry of the thorax (HP:0001555)2.01055767
80Abnormality of the intrinsic pathway (HP:0010989)2.00233678
81Abnormal number of erythroid precursors (HP:0012131)17.6829214
82Abnormality of cells of the erythroid lineage (HP:0012130)15.7826694
83Hypophosphatemic rickets (HP:0004912)1.99359466
84Abnormality of mucopolysaccharide metabolism (HP:0011020)1.99166730
85Abnormality of polysaccharide metabolism (HP:0011012)1.99166730
86Abnormality of glycosaminoglycan metabolism (HP:0004371)1.99166730
87Hepatoblastoma (HP:0002884)1.95150994
88Submucous cleft hard palate (HP:0000176)1.95063864
89Ovoid vertebral bodies (HP:0003300)1.93966350
90Frequent falls (HP:0002359)1.93420942
91Pancreatic islet-cell hyperplasia (HP:0004510)1.92488172
92Vertebral arch anomaly (HP:0008438)1.91738416
93Alacrima (HP:0000522)1.90914578
94Abnormality of the nasal septum (HP:0000419)1.90216883
95Rickets (HP:0002748)1.86808930
96Deep venous thrombosis (HP:0002625)1.85788145
97Azoospermia (HP:0000027)1.85395477
98Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.84187967
99Arthropathy (HP:0003040)1.83177268
100Vascular tortuosity (HP:0004948)1.83057887
101Abnormality of the fingertips (HP:0001211)1.82422315
102Vertebral compression fractures (HP:0002953)1.81309329
103Back pain (HP:0003418)1.80495998
104Hyperammonemia (HP:0001987)1.80350378
105Wide nose (HP:0000445)1.79041974
106Abnormality of the Achilles tendon (HP:0005109)1.78619587
107Limited elbow extension (HP:0001377)1.78183152
108Abnormality of the wing of the ilium (HP:0011867)1.77804758
109Striae distensae (HP:0001065)1.76362286
110Abnormality of monocarboxylic acid metabolism (HP:0010996)1.76213600
111Dysostosis multiplex (HP:0000943)1.75021093
112Joint swelling (HP:0001386)1.74675473
113Peritonitis (HP:0002586)1.74298874
114Juvenile onset (HP:0003621)1.72762768
115Sensorimotor neuropathy (HP:0007141)1.72698464
116Thoracic kyphosis (HP:0002942)1.70123324
117Widely patent fontanelles and sutures (HP:0004492)1.69941852
118Chondrocalcinosis (HP:0000934)1.68886784
119Hyperglycinuria (HP:0003108)1.68180866
120Abnormality of the thoracic spine (HP:0100711)1.67433968
121Pigmentary retinal degeneration (HP:0001146)1.65868919
122Osteomalacia (HP:0002749)1.64544315
123Abnormal cartilage morphology (HP:0002763)1.63355587
124Ventricular tachycardia (HP:0004756)1.62960096
125Hypoglycemic coma (HP:0001325)1.60644497
126Lethargy (HP:0001254)1.59854761
127Abnormality of fatty-acid metabolism (HP:0004359)1.59279918
128Gastrointestinal dysmotility (HP:0002579)1.57138514
129Sudden cardiac death (HP:0001645)1.54917616
130Conjunctival hamartoma (HP:0100780)1.53679969
131Abnormality of the gastric mucosa (HP:0004295)1.51684334
132Aneurysm (HP:0002617)1.51368380
133Hemorrhage of the eye (HP:0011885)1.50799223
134Hyperglycinemia (HP:0002154)1.50664903
135Tubular atrophy (HP:0000092)1.50313517
136Ankyloglossia (HP:0010296)1.50291912
137Turricephaly (HP:0000262)1.48625378
138Abnormality of serine family amino acid metabolism (HP:0010894)1.47428610
139Abnormality of glycine metabolism (HP:0010895)1.47428610
140Hypoalphalipoproteinemia (HP:0003233)1.46417620
141Facial diplegia (HP:0001349)1.46035105
142Pancreatitis (HP:0001733)1.40787885
143Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.40677916
144Growth hormone excess (HP:0000845)1.37572658
145Vascular calcification (HP:0004934)1.36903681
146Increased variability in muscle fiber diameter (HP:0003557)1.35520678
147Xanthomatosis (HP:0000991)1.34206147
148Abnormality of nucleobase metabolism (HP:0010932)1.33354530
149Curly hair (HP:0002212)1.32638517
150Conjugated hyperbilirubinemia (HP:0002908)1.32067367
151Abnormality of oral frenula (HP:0000190)1.31204440
152Aortic regurgitation (HP:0001659)1.30829680
153Spastic diplegia (HP:0001264)1.30151997
154Seborrheic dermatitis (HP:0001051)1.29465856
155Cardiovascular calcification (HP:0011915)1.28909868
156Macroglossia (HP:0000158)1.28845689
157Testicular neoplasm (HP:0010788)1.27858092
158Abnormality of the renal cortex (HP:0011035)1.24878301
159Abdominal situs inversus (HP:0003363)1.24835059
160Abnormality of abdominal situs (HP:0011620)1.24835059
161Scapular winging (HP:0003691)1.23796248
162Cerebral hemorrhage (HP:0001342)1.22066160
163Hyperglycemia (HP:0003074)1.20610384
164Broad metatarsal (HP:0001783)1.20108416
165Stroke (HP:0001297)1.18964185
166Amyloidosis (HP:0011034)1.18376972
167Flat acetabular roof (HP:0003180)1.18339415
168Pheochromocytoma (HP:0002666)1.18266526
169Hyperparathyroidism (HP:0000843)1.17761382
170Atrophic scars (HP:0001075)1.17417689
171Hypotension (HP:0002615)1.15944103
172Abnormality of aromatic amino acid family metabolism (HP:0004338)1.15054706
173Abnormal EKG (HP:0003115)1.14808242
174Skin nodule (HP:0200036)1.14466684
175Dicarboxylic aciduria (HP:0003215)1.14318963
176Abnormality of dicarboxylic acid metabolism (HP:0010995)1.14318963
177Agitation (HP:0000713)1.13774965
178Cupped ribs (HP:0000887)1.12737830
179Pustule (HP:0200039)1.12613984
180Abnormality of skeletal muscle fiber size (HP:0012084)1.12500640

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FGFR46.79750681
2MST45.92475859
3MST1R5.41612659
4ERBB45.25164669
5FGFR34.48859977
6BCKDK3.58241114
7TRIB33.50111797
8TGFBR23.46496028
9MYLK3.34686598
10EPHA33.12035176
11PKN22.58345885
12LRRK22.56257364
13KSR22.50019101
14PIK3CG2.40700186
15MET2.21920205
16LATS12.21656459
17CDK122.17875697
18RIPK42.16759757
19AKT31.85156661
20ERN11.82219804
21STK101.77098702
22MAP3K91.66339445
23MAP3K21.61023037
24LMTK21.55599432
25PAK31.50482200
26ZAP701.44378321
27PDGFRB1.43759400
28PTK61.42311158
29WNK41.37735916
30NUAK11.37383225
31ROCK21.31649472
32STK391.30309848
33NLK1.26392717
34FGFR21.23250561
35PDK21.17297286
36FER1.17094026
37FGFR11.16811707
38MAP2K11.16700201
39EPHA21.16651688
40TTN1.15262872
41TESK11.12437897
42DDR21.08999075
43PRKCI1.04467623
44MAP3K61.02369556
45LATS21.02239291
46MAPK110.99702744
47PRKG20.99118520
48NEK90.94996246
49RPS6KA20.92727993
50SGK4940.92035590
51SGK2230.92035590
52PDK40.89923518
53PDK30.89923518
54ROCK10.88598077
55TYK20.85948124
56EPHB10.84104991
57MAP2K20.83908960
58NEK10.83738757
59IRAK10.82832392
60SGK30.80133650
61PAK20.79083978
62NME10.78254685
63ICK0.77129623
64RIPK10.77022459
65SGK20.75717339
66PDPK10.75051346
67PAK60.72699056
68EEF2K0.72084259
69CAMK1D0.71648407
70MAPKAPK30.70277843
71MARK20.69034726
72TIE10.68885355
73FYN0.68594358
74JAK10.67008248
75DYRK1B0.65328837
76STK38L0.65244727
77LIMK10.64752109
78CDK60.63224328
79PAK40.62952357
80PTK20.62947265
81MAP3K80.62843010
82FRK0.62512057
83PRPF4B0.62409289
84CDC42BPA0.61629734
85NTRK10.59391293
86GRK60.57435449
87PDK10.57328895
88DMPK0.56813706
89RET0.55538780
90MAP2K30.53359119
91MAP2K60.53358184
92MATK0.52775842
93BCR0.51751232
94EIF2AK10.51071098
95DAPK30.49516031
96KSR10.48784002
97EGFR0.48479288
98RPS6KC10.48369902
99RPS6KL10.48369902
100MTOR0.48075894
101MELK0.47600258
102BMX0.46818321
103PIK3CA0.46774447
104MINK10.46620153
105GSK3A0.45111414
106PHKG20.44504009
107PHKG10.44504009
108PDGFRA0.42926803
109IGF1R0.42549704
110IRAK30.42434319
111SRC0.42410446
112WNK10.41867079
113SIK10.41657844
114MAP3K70.41256252
115RPS6KB20.40392569
116TYRO30.40378002
117RAF10.39416217
118CSK0.38001003
119JAK20.37746151
120SGK10.36815766
121PAK10.36495397
122PRKACG0.36197297
123CAMKK10.36159510
124MAP3K50.35812640
125RPS6KA60.35253491
126HIPK20.34456021
127TAOK10.34019075
128PBK0.33427205
129MAPKAPK20.33314985
130RPS6KB10.32386513
131YES10.32004448
132SMG10.30737233
133PRKAA20.30376050
134CDK190.30103248
135OXSR10.29944785
136ERBB20.29558286
137MAPK30.28812115
138PRKAA10.28186426
139MAP2K40.27965120
140ILK0.27608259
141MAP3K130.27249255
142STK380.26901244
143MAP3K140.26319322
144ALK0.26016600
145PTK2B0.25292260
146INSR0.25288412
147PRKD10.24971247
148RPS6KA10.24886540
149FGR0.24431997
150CDK50.24143201
151CAMK2B0.22415808
152MAP3K10.21953640
153CAMK2G0.21153010
154MAP3K30.20846871

Predicted pathways (KEGG)

RankGene SetZ-score
1Collecting duct acid secretion_Homo sapiens_hsa049667.72725811
2Complement and coagulation cascades_Homo sapiens_hsa046105.45545262
3Gastric acid secretion_Homo sapiens_hsa049715.31533307
4Fat digestion and absorption_Homo sapiens_hsa049754.17034703
5Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.96810063
6Vitamin digestion and absorption_Homo sapiens_hsa049773.61315426
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.17489195
8Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.03318264
9Staphylococcus aureus infection_Homo sapiens_hsa051503.00243738
10Linoleic acid metabolism_Homo sapiens_hsa005912.97794140
11Chemical carcinogenesis_Homo sapiens_hsa052042.71475331
12Fatty acid biosynthesis_Homo sapiens_hsa000612.64615192
13Sulfur metabolism_Homo sapiens_hsa009202.59494513
14Glycosaminoglycan degradation_Homo sapiens_hsa005312.26583495
15Other glycan degradation_Homo sapiens_hsa005112.22293818
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.19181814
17Glutathione metabolism_Homo sapiens_hsa004802.15384738
18Steroid biosynthesis_Homo sapiens_hsa001002.00225757
19Ether lipid metabolism_Homo sapiens_hsa005651.90855700
20Pertussis_Homo sapiens_hsa051331.83737782
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.79154266
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.69861824
23Pancreatic secretion_Homo sapiens_hsa049721.69715064
24Oxidative phosphorylation_Homo sapiens_hsa001901.58688166
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55195090
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52590815
27Arginine and proline metabolism_Homo sapiens_hsa003301.29765685
28Fatty acid degradation_Homo sapiens_hsa000711.29274982
29Propanoate metabolism_Homo sapiens_hsa006401.21398963
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.19482174
31Nitrogen metabolism_Homo sapiens_hsa009101.19423281
32Renin-angiotensin system_Homo sapiens_hsa046141.12599261
33Arachidonic acid metabolism_Homo sapiens_hsa005901.10236365
34ECM-receptor interaction_Homo sapiens_hsa045121.08088490
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.08039903
36Protein digestion and absorption_Homo sapiens_hsa049741.07015696
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06602336
38Glycerolipid metabolism_Homo sapiens_hsa005611.05031348
39Retinol metabolism_Homo sapiens_hsa008300.98034664
40Vascular smooth muscle contraction_Homo sapiens_hsa042700.95873991
41Thyroid hormone synthesis_Homo sapiens_hsa049180.90929026
42Bile secretion_Homo sapiens_hsa049760.90193685
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.89950871
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89939705
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89270077
46Prion diseases_Homo sapiens_hsa050200.85975634
47Vitamin B6 metabolism_Homo sapiens_hsa007500.84461064
48N-Glycan biosynthesis_Homo sapiens_hsa005100.83992400
49Adherens junction_Homo sapiens_hsa045200.83468318
50Sphingolipid metabolism_Homo sapiens_hsa006000.81698054
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.76566486
52Glycerophospholipid metabolism_Homo sapiens_hsa005640.76241015
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76200667
54Butanoate metabolism_Homo sapiens_hsa006500.73907128
55Phenylalanine metabolism_Homo sapiens_hsa003600.72052860
56Histidine metabolism_Homo sapiens_hsa003400.69835180
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.69250311
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.68457069
59beta-Alanine metabolism_Homo sapiens_hsa004100.66710989
60Pyruvate metabolism_Homo sapiens_hsa006200.66333022
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65081973
62Carbon metabolism_Homo sapiens_hsa012000.63768047
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62291615
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61162736
65Fatty acid metabolism_Homo sapiens_hsa012120.58562761
66Arginine biosynthesis_Homo sapiens_hsa002200.53838032
67Mineral absorption_Homo sapiens_hsa049780.52489685
68Hepatitis C_Homo sapiens_hsa051600.51055105
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.50230255
70Tyrosine metabolism_Homo sapiens_hsa003500.48733709
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46319049
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45032386
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43308137
74Salivary secretion_Homo sapiens_hsa049700.42046242
75Lysine degradation_Homo sapiens_hsa003100.40673646
76PPAR signaling pathway_Homo sapiens_hsa033200.35566217
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35521490
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.34158638
79Tryptophan metabolism_Homo sapiens_hsa003800.33644071
80Asthma_Homo sapiens_hsa053100.33164229
81Tight junction_Homo sapiens_hsa045300.32685079
82Biosynthesis of amino acids_Homo sapiens_hsa012300.31692547
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31207152
84Choline metabolism in cancer_Homo sapiens_hsa052310.31048641
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.30646786
86Insulin signaling pathway_Homo sapiens_hsa049100.28783112
87Toxoplasmosis_Homo sapiens_hsa051450.28053880
88Phagosome_Homo sapiens_hsa041450.26444698
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.26206324
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.25773788
91Cardiac muscle contraction_Homo sapiens_hsa042600.24937402
92Lysosome_Homo sapiens_hsa041420.23677587
93Ovarian steroidogenesis_Homo sapiens_hsa049130.23594487
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.23261722
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.22213866
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.22101881
97Amoebiasis_Homo sapiens_hsa051460.21879891
98HIF-1 signaling pathway_Homo sapiens_hsa040660.21289670
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.21209198
100Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.19079966
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.18876502
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.18429881
103Peroxisome_Homo sapiens_hsa041460.18278518
104Estrogen signaling pathway_Homo sapiens_hsa049150.18037980
105Thyroid cancer_Homo sapiens_hsa052160.16868709
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.16774137
107Fructose and mannose metabolism_Homo sapiens_hsa000510.16761938
108Insulin secretion_Homo sapiens_hsa049110.16598340
109Fatty acid elongation_Homo sapiens_hsa000620.16343518
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.12757088
111Cholinergic synapse_Homo sapiens_hsa047250.12130628
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.11399282
113Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.11043323
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.10775342
115Pentose phosphate pathway_Homo sapiens_hsa000300.09842248
116VEGF signaling pathway_Homo sapiens_hsa043700.09716718
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.08792593
118Vibrio cholerae infection_Homo sapiens_hsa051100.08710642
119GnRH signaling pathway_Homo sapiens_hsa049120.07921828
120ABC transporters_Homo sapiens_hsa020100.06791975
121Proteoglycans in cancer_Homo sapiens_hsa052050.06747219
122Long-term potentiation_Homo sapiens_hsa047200.06639687
123cAMP signaling pathway_Homo sapiens_hsa040240.06633472
124Dorso-ventral axis formation_Homo sapiens_hsa043200.03564525
125Renin secretion_Homo sapiens_hsa049240.03401265
126Alzheimers disease_Homo sapiens_hsa050100.02817062
127Sulfur relay system_Homo sapiens_hsa041220.02705773
128Metabolic pathways_Homo sapiens_hsa011000.02655205
129Bladder cancer_Homo sapiens_hsa052190.02623037
130Dilated cardiomyopathy_Homo sapiens_hsa054140.02514789
131Insulin resistance_Homo sapiens_hsa049310.02396905
132Ras signaling pathway_Homo sapiens_hsa040140.02099079
133Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.01737104
134Starch and sucrose metabolism_Homo sapiens_hsa005000.01724640
135Gap junction_Homo sapiens_hsa045400.00751684
136Galactose metabolism_Homo sapiens_hsa000520.00439759
137Focal adhesion_Homo sapiens_hsa04510-0.0010805
138Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.0001209

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