PGD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: 6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.58620491
2positive regulation by organism of defense response of other organism involved in symbiotic interact4.58620491
3modulation by symbiont of host immune response (GO:0052553)4.58620491
4positive regulation by symbiont of host defense response (GO:0052509)4.58620491
5modulation by symbiont of host defense response (GO:0052031)4.58620491
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.58620491
7glucose 6-phosphate metabolic process (GO:0051156)4.46211821
8response to peptidoglycan (GO:0032494)4.42569145
9neutrophil activation involved in immune response (GO:0002283)4.38815141
10low-density lipoprotein particle clearance (GO:0034383)4.18737981
11respiratory burst (GO:0045730)3.99251652
12negative regulation of erythrocyte differentiation (GO:0045647)3.79972440
13glycosphingolipid catabolic process (GO:0046479)3.78420449
14leukocyte aggregation (GO:0070486)3.68497798
15response to fungus (GO:0009620)3.63118981
16immunoglobulin mediated immune response (GO:0016064)3.62976540
17regulation of interferon-beta biosynthetic process (GO:0045357)3.57019969
18Arp2/3 complex-mediated actin nucleation (GO:0034314)3.55428499
19positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.53907768
20alpha-linolenic acid metabolic process (GO:0036109)3.49749458
21production of molecular mediator involved in inflammatory response (GO:0002532)3.42038244
22macrophage activation involved in immune response (GO:0002281)3.37890499
23neutrophil mediated immunity (GO:0002446)3.37608294
24regulation of superoxide anion generation (GO:0032928)3.35932960
25glycolipid catabolic process (GO:0019377)3.32727554
26hydrogen peroxide biosynthetic process (GO:0050665)3.32651603
27antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.32593386
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.32593386
29reactive oxygen species biosynthetic process (GO:1903409)3.28346432
30Golgi transport vesicle coating (GO:0048200)3.27987338
31COPI coating of Golgi vesicle (GO:0048205)3.27987338
32response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.25561638
33response to host immune response (GO:0052572)3.25561638
34defense response to fungus (GO:0050832)3.22770883
35barbed-end actin filament capping (GO:0051016)3.19184363
36neutrophil activation (GO:0042119)3.18515546
37negative regulation of interleukin-12 production (GO:0032695)3.17482051
38granulocyte activation (GO:0036230)3.17141332
39positive regulation of interferon-alpha production (GO:0032727)3.16537356
40positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.13775157
41cellular response to thyroid hormone stimulus (GO:0097067)3.13420398
42daunorubicin metabolic process (GO:0044597)3.11239578
43polyketide metabolic process (GO:0030638)3.11239578
44doxorubicin metabolic process (GO:0044598)3.11239578
45* pentose-phosphate shunt (GO:0006098)3.10184936
46negative regulation of phagocytosis (GO:0050765)3.07866960
47amino sugar catabolic process (GO:0046348)3.06716637
48protein localization to endosome (GO:0036010)3.06161434
49detection of other organism (GO:0098543)3.05404428
50epithelial cell differentiation involved in prostate gland development (GO:0060742)3.05399815
51regulation of cholesterol storage (GO:0010885)3.01660344
52leukocyte migration involved in inflammatory response (GO:0002523)3.01329705
53cellular extravasation (GO:0045123)3.00973844
54B cell mediated immunity (GO:0019724)3.00092024
55response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.99124098
56response to host (GO:0075136)2.99124098
57response to host defenses (GO:0052200)2.99124098
58regulation of interferon-alpha production (GO:0032647)2.98064826
59leukocyte mediated cytotoxicity (GO:0001909)2.96839961
60oligosaccharide catabolic process (GO:0009313)2.96755991
61positive regulation of chemokine biosynthetic process (GO:0045080)2.94833920
62natural killer cell mediated immunity (GO:0002228)2.94678553
63natural killer cell mediated cytotoxicity (GO:0042267)2.94678553
64* NADPH regeneration (GO:0006740)2.89196363
65antigen processing and presentation of endogenous antigen (GO:0019883)2.89167815
66ceramide catabolic process (GO:0046514)2.82755140
67superoxide anion generation (GO:0042554)2.80662264
68lipopolysaccharide-mediated signaling pathway (GO:0031663)2.80055163
69leukotriene metabolic process (GO:0006691)2.79180802
70response to muramyl dipeptide (GO:0032495)2.76209022
71response to thyroid hormone (GO:0097066)2.75550601
723-UTR-mediated mRNA stabilization (GO:0070935)2.75370620
73pinocytosis (GO:0006907)2.73864012
74detection of external biotic stimulus (GO:0098581)2.73100897
75nuclear pore complex assembly (GO:0051292)2.72457238
76detection of bacterium (GO:0016045)2.72441394
77DNA unwinding involved in DNA replication (GO:0006268)2.71248976
78* pentose metabolic process (GO:0019321)2.69948732
79regulation of early endosome to late endosome transport (GO:2000641)2.66271540
80T cell apoptotic process (GO:0070231)2.65599028
81stress fiber assembly (GO:0043149)2.63146012
82antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.62825392
83aminoglycoside antibiotic metabolic process (GO:0030647)2.62523442
84regulation of mast cell degranulation (GO:0043304)2.61854338
85regulation of leukocyte degranulation (GO:0043300)2.61745427
86glycoside metabolic process (GO:0016137)2.60526897
87positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.59771304
88modulation by symbiont of host cellular process (GO:0044068)2.59286738
89apoptotic cell clearance (GO:0043277)2.58673632
90activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.58523536
91actin nucleation (GO:0045010)2.58101123
92macrophage differentiation (GO:0030225)2.56431432
93positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.55545643
94sequestering of metal ion (GO:0051238)2.53524624
95regulation of podosome assembly (GO:0071801)2.53411136
96regulation of protein heterodimerization activity (GO:0043497)2.53198188
97positive regulation of Cdc42 GTPase activity (GO:0043089)2.51991356
98myeloid cell homeostasis (GO:0002262)2.51631783
99regulation of chemokine biosynthetic process (GO:0045073)2.51441352
100detection of biotic stimulus (GO:0009595)2.51438496
101positive regulation of interferon-beta production (GO:0032728)2.51262427
102establishment of integrated proviral latency (GO:0075713)2.50611301
103regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.50000610
104regulation of interleukin-8 biosynthetic process (GO:0045414)2.49224182
105leukocyte cell-cell adhesion (GO:0007159)2.48800288
106formation of translation preinitiation complex (GO:0001731)2.47598456
107negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.47503872
108regulation of regulated secretory pathway (GO:1903305)2.46697237
109cellular response to zinc ion (GO:0071294)2.44488757
110positive regulation of cellular amide metabolic process (GO:0034250)2.44334866
111modulation of growth of symbiont involved in interaction with host (GO:0044144)2.43487540
112regulation of growth of symbiont in host (GO:0044126)2.43487540
113negative regulation of growth of symbiont in host (GO:0044130)2.43487540
114negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.43487540
115positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.43243293
116positive regulation of mast cell activation (GO:0033005)2.43223867
117regulation of myeloid leukocyte mediated immunity (GO:0002886)2.41777291
118regulation of integrin activation (GO:0033623)2.41773695
119regulation of mast cell activation involved in immune response (GO:0033006)2.41596044
120regulation of mast cell activation (GO:0033003)2.40616738
121myeloid cell activation involved in immune response (GO:0002275)2.40481255
122myeloid leukocyte mediated immunity (GO:0002444)2.39242953
123positive regulation of leukocyte degranulation (GO:0043302)2.38658070
124negative regulation of myeloid cell apoptotic process (GO:0033033)2.38288251
125modulation by virus of host process (GO:0019054)2.37850717
126disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.37045316
127killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.37045316
128regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.36516868
129mRNA stabilization (GO:0048255)2.35226488
130RNA stabilization (GO:0043489)2.35226488
131positive regulation of antigen processing and presentation (GO:0002579)2.34091632
132IMP biosynthetic process (GO:0006188)2.34007558
133antigen processing and presentation via MHC class Ib (GO:0002475)2.33859596
134membrane lipid catabolic process (GO:0046466)2.33456833
135N-acetylneuraminate metabolic process (GO:0006054)2.32510004
136response to laminar fluid shear stress (GO:0034616)2.32229023
137* NADP metabolic process (GO:0006739)2.32029747
138detection of molecule of bacterial origin (GO:0032490)2.31744630
139regulation of B cell receptor signaling pathway (GO:0050855)2.30686514
140mannose metabolic process (GO:0006013)2.29169458
141establishment of viral latency (GO:0019043)2.28823716
142sphingolipid catabolic process (GO:0030149)2.27963218
143mitotic chromosome condensation (GO:0007076)2.26964665
144spliceosomal tri-snRNP complex assembly (GO:0000244)2.26222503
145regulation of mononuclear cell migration (GO:0071675)2.26159824
146lymphocyte apoptotic process (GO:0070227)2.25471126
147* glucose catabolic process (GO:0006007)2.25424978
148tricarboxylic acid metabolic process (GO:0072350)2.25257420
149regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.24367107
150positive regulation of B cell differentiation (GO:0045579)2.24107371
151chronic inflammatory response (GO:0002544)2.23884853
152neutrophil chemotaxis (GO:0030593)2.23821697
153cytokine secretion (GO:0050663)2.19361210
154positive regulation of gamma-delta T cell activation (GO:0046645)2.18501870

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.84160849
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.43368176
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.30511129
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.71350047
5MYB_21317192_ChIP-Seq_ERMYB_Mouse2.71225358
6BP1_19119308_ChIP-ChIP_Hs578T_Human2.62909586
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.61537771
8* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.60857545
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.50635745
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.40594527
11* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.40326010
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.33822402
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.32258638
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.30704961
15VDR_21846776_ChIP-Seq_THP-1_Human2.25627071
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.25115674
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.15359897
18BRD4_27068464_Chip-Seq_AML-cells_Mouse2.05235662
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.00848347
20MYC_22102868_ChIP-Seq_BL_Human1.96394682
21SPI1_23547873_ChIP-Seq_NB4_Human1.89817848
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.89580580
23SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.81938701
24RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.74958240
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.72788324
26ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.70739709
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.70042408
28MYC_18555785_ChIP-Seq_MESCs_Mouse1.66827773
29CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.66102475
30VDR_24763502_ChIP-Seq_THP-1_Human1.65614469
31* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.65311077
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.56219688
33* ELK3_25401928_ChIP-Seq_HUVEC_Human1.52687822
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.51856717
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.50376424
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.49129672
37* MAF_26560356_Chip-Seq_TH1_Human1.48066149
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46520029
39ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46490883
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.42574476
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.41987277
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39042293
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.38620809
44TFEB_21752829_ChIP-Seq_HELA_Human1.36324542
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.35255471
46DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.32713661
47* UTX_26944678_Chip-Seq_JUKART_Human1.32451926
48CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31966454
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31268238
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29827896
51* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29782455
52MYB_26560356_Chip-Seq_TH2_Human1.29780143
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.29605071
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.29499239
55TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27862687
56TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.27720280
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.27305012
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26515906
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25960647
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25776914
61STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.25737643
62AR_21909140_ChIP-Seq_LNCAP_Human1.23436167
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22450262
64THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22314815
65ZNF263_19887448_ChIP-Seq_K562_Human1.21658671
66MYC_18358816_ChIP-ChIP_MESCs_Mouse1.19768080
67* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19045070
68MYB_26560356_Chip-Seq_TH1_Human1.18474898
69TCF7_22412390_ChIP-Seq_EML_Mouse1.17168081
70SPI1_23127762_ChIP-Seq_K562_Human1.16776322
71CLOCK_20551151_ChIP-Seq_293T_Human1.16471497
72* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16319622
73TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16045067
74TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15938675
75CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15926549
76PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15729662
77POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13961660
78ATF3_27146783_Chip-Seq_COLON_Human1.11023200
79* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.10964607
80GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09002809
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.08794640
82SCL_19346495_ChIP-Seq_HPC-7_Human1.08695377
83* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.08539134
84* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.08408950
85SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.08036107
86NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07572460
87* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.07188372
88STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.07074312
89* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.06919539
90CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05765136
91* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05727336
92KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.05558642
93* RACK7_27058665_Chip-Seq_MCF-7_Human1.05286947
94GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.05240025
95* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04333710
96ELF1_17652178_ChIP-ChIP_JURKAT_Human1.04313532
97JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.04171330
98GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03805612
99ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.03599442
100HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03446242
101MAF_26560356_Chip-Seq_TH2_Human1.03312399
102XRN2_22483619_ChIP-Seq_HELA_Human1.03240530
103PU_27001747_Chip-Seq_BMDM_Mouse1.03085093
104PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02495249
105NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02056560
106* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01518363
107* E2F1_21310950_ChIP-Seq_MCF-7_Human0.99553257
108CREB1_15753290_ChIP-ChIP_HEK293T_Human0.98311353
109MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97934216
110KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97865191
111* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96499420
112LXR_22292898_ChIP-Seq_THP-1_Human0.96463150
113* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96389326
114* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95606984
115RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94093146
116* NCOR1_26117541_ChIP-Seq_K562_Human0.93799857
117DCP1A_22483619_ChIP-Seq_HELA_Human0.90822349
118HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90755597
119CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90642613
120* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.90577761
121* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.89514704
122ETS1_20019798_ChIP-Seq_JURKAT_Human0.88891674
123* KDM2B_26808549_Chip-Seq_DND41_Human0.88218549
124NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.87156542

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.31235583
2MP0003436_decreased_susceptibility_to3.31162466
3MP0005058_abnormal_lysosome_morphology2.99499704
4MP0005451_abnormal_body_composition2.59629849
5MP0009785_altered_susceptibility_to2.47497448
6MP0002419_abnormal_innate_immunity2.42830427
7MP0001835_abnormal_antigen_presentation2.39796026
8MP0009278_abnormal_bone_marrow2.21314871
9MP0009840_abnormal_foam_cell2.18097226
10MP0010352_gastrointestinal_tract_polyps2.17841666
11MP0003705_abnormal_hypodermis_morpholog2.15316152
12MP0005025_abnormal_response_to2.08198515
13MP0003566_abnormal_cell_adhesion2.01491125
14MP0002877_abnormal_melanocyte_morpholog1.94822979
15MP0005000_abnormal_immune_tolerance1.91479373
16MP0003172_abnormal_lysosome_physiology1.89977440
17MP0003693_abnormal_embryo_hatching1.89551207
18MP0005464_abnormal_platelet_physiology1.87106014
19MP0001533_abnormal_skeleton_physiology1.87008255
20MP0002148_abnormal_hypersensitivity_rea1.86999701
21MP0002452_abnormal_antigen_presenting1.81268153
22MP0005076_abnormal_cell_differentiation1.78822224
23MP0003191_abnormal_cellular_cholesterol1.76669963
24MP0002139_abnormal_hepatobiliary_system1.75991910
25MP0000858_altered_metastatic_potential1.75855181
26MP0006082_CNS_inflammation1.74409203
27MP0010307_abnormal_tumor_latency1.73694065
28MP0003724_increased_susceptibility_to1.72233597
29MP0003300_gastrointestinal_ulcer1.71646883
30MP0003656_abnormal_erythrocyte_physiolo1.69269531
31MP0000343_altered_response_to1.66709896
32MP0003448_altered_tumor_morphology1.66205483
33MP0002405_respiratory_system_inflammati1.63751606
34MP0005397_hematopoietic_system_phenotyp1.63167787
35MP0001545_abnormal_hematopoietic_system1.63167787
36MP0000685_abnormal_immune_system1.62202753
37MP0008438_abnormal_cutaneous_collagen1.60866127
38MP0004947_skin_inflammation1.59384291
39MP0000604_amyloidosis1.59325391
40MP0009333_abnormal_splenocyte_physiolog1.58289729
41MP0001819_abnormal_immune_cell1.57263400
42MP0002420_abnormal_adaptive_immunity1.55280595
43MP0001800_abnormal_humoral_immune1.54727635
44MP0005387_immune_system_phenotype1.53395174
45MP0001790_abnormal_immune_system1.53395174
46MP0002723_abnormal_immune_serum1.52032470
47MP0000490_abnormal_crypts_of1.48208379
48MP0001853_heart_inflammation1.46789639
49MP0001845_abnormal_inflammatory_respons1.45734109
50MP0005023_abnormal_wound_healing1.43605342
51MP0002396_abnormal_hematopoietic_system1.40098400
52MP0010155_abnormal_intestine_physiology1.39854071
53MP0003186_abnormal_redox_activity1.34367258
54MP0002254_reproductive_system_inflammat1.26609533
55MP0008007_abnormal_cellular_replicative1.23224920
56MP0001958_emphysema1.23020657
57MP0003111_abnormal_nucleus_morphology1.21452214
58MP0004233_abnormal_muscle_weight1.21125291
59MP0002398_abnormal_bone_marrow1.20105423
60MP0008469_abnormal_protein_level1.19872705
61MP0000716_abnormal_immune_system1.19814718
62MP0001915_intracranial_hemorrhage1.19351137
63MP0004808_abnormal_hematopoietic_stem1.18882108
64MP0003183_abnormal_peptide_metabolism1.17390502
65MP0004957_abnormal_blastocyst_morpholog1.16247767
66MP0004185_abnormal_adipocyte_glucose1.15539442
67MP0002132_abnormal_respiratory_system1.14271914
68MP0000689_abnormal_spleen_morphology1.13754815
69MP0002429_abnormal_blood_cell1.11010279
70MP0002722_abnormal_immune_system1.10466533
71MP0008932_abnormal_embryonic_tissue1.07356558
72MP0000465_gastrointestinal_hemorrhage1.06382706
73MP0003077_abnormal_cell_cycle1.05234315
74MP0003329_amyloid_beta_deposits1.04339316
75MP0000313_abnormal_cell_death1.03202925
76MP0005671_abnormal_response_to1.02648060
77MP0003075_altered_response_to1.02411692
78MP0009672_abnormal_birth_weight1.01959901
79MP0003828_pulmonary_edema1.01100251
80MP0010094_abnormal_chromosome_stability0.98780206
81MP0009764_decreased_sensitivity_to0.98681277
82MP0005390_skeleton_phenotype0.98017171
83MP0005257_abnormal_intraocular_pressure0.96983351
84MP0004883_abnormal_blood_vessel0.94441652
85MP0002006_tumorigenesis0.93537515
86MP0003453_abnormal_keratinocyte_physiol0.92252380
87MP0000569_abnormal_digit_pigmentation0.91916455
88MP0002998_abnormal_bone_remodeling0.91789776
89MP0001873_stomach_inflammation0.91302396
90MP0004858_abnormal_nervous_system0.90952250
91MP0002019_abnormal_tumor_incidence0.90869877
92MP0002166_altered_tumor_susceptibility0.88460426
93MP0002796_impaired_skin_barrier0.88218595
94MP0002080_prenatal_lethality0.87925721
95MP0006054_spinal_hemorrhage0.87873059
96MP0001851_eye_inflammation0.87681595
97MP0003690_abnormal_glial_cell0.87589851
98MP0000358_abnormal_cell_content/0.87525065
99MP0001730_embryonic_growth_arrest0.87225088
100MP0005621_abnormal_cell_physiology0.86836164
101MP0001881_abnormal_mammary_gland0.86769934
102MP0005164_abnormal_response_to0.86398552
103MP0003806_abnormal_nucleotide_metabolis0.85845473
104MP0002933_joint_inflammation0.85620795
105MP0005666_abnormal_adipose_tissue0.84716315
106MP0005310_abnormal_salivary_gland0.84518522
107MP0005167_abnormal_blood-brain_barrier0.84417620
108MP0000350_abnormal_cell_proliferation0.82888854
109MP0005248_abnormal_Harderian_gland0.82874160
110MP0004510_myositis0.82648445
111MP0001727_abnormal_embryo_implantation0.81581540
112MP0001849_ear_inflammation0.81431923
113MP0005670_abnormal_white_adipose0.80850700
114MP0005083_abnormal_biliary_tract0.80614118
115MP0004782_abnormal_surfactant_physiolog0.79800293
116MP0003091_abnormal_cell_migration0.79327196
117MP0009115_abnormal_fat_cell0.77148885
118MP0005174_abnormal_tail_pigmentation0.75362119
119MP0000249_abnormal_blood_vessel0.74648889
120MP0005166_decreased_susceptibility_to0.74108728
121MP0010234_abnormal_vibrissa_follicle0.74041388
122MP0000371_diluted_coat_color0.73759194
123MP0008260_abnormal_autophagy0.72351697
124MP0000609_abnormal_liver_physiology0.71814079
125MP0009763_increased_sensitivity_to0.71373416
126MP0003221_abnormal_cardiomyocyte_apopto0.71177503

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.23824801
2Recurrent abscess formation (HP:0002722)6.09761071
3Recurrent bacterial skin infections (HP:0005406)5.23162435
4Recurrent gram-negative bacterial infections (HP:0005420)4.94153135
5Abnormality of macrophages (HP:0004311)4.55996548
6Vacuolated lymphocytes (HP:0001922)4.23554624
7Abnormal gallbladder physiology (HP:0012438)3.77959232
8Cholecystitis (HP:0001082)3.77959232
9Increased cerebral lipofuscin (HP:0011813)3.66429603
10Chronic obstructive pulmonary disease (HP:0006510)3.61390933
11Obstructive lung disease (HP:0006536)3.61390933
12Autoimmune thrombocytopenia (HP:0001973)3.56046845
13Mediastinal lymphadenopathy (HP:0100721)3.48739752
14Gingivitis (HP:0000230)3.43873091
15Pustule (HP:0200039)3.15709621
16Interstitial pulmonary disease (HP:0006530)3.14786436
17Cortical dysplasia (HP:0002539)3.14196666
18Increased neuronal autofluorescent lipopigment (HP:0002074)3.11676315
19Axonal loss (HP:0003447)3.09058005
20Elevated erythrocyte sedimentation rate (HP:0003565)3.07598265
21Recurrent fungal infections (HP:0002841)3.06310249
22Dysostosis multiplex (HP:0000943)3.01266215
23Myositis (HP:0100614)2.99932229
24Recurrent skin infections (HP:0001581)2.96158445
25Cellulitis (HP:0100658)2.88406958
26Urticaria (HP:0001025)2.71636905
27Osteolytic defects of the hand bones (HP:0009699)2.70779101
28Osteolytic defects of the phalanges of the hand (HP:0009771)2.70779101
29Systemic lupus erythematosus (HP:0002725)2.69261976
30Periodontitis (HP:0000704)2.68300658
31Mucopolysacchariduria (HP:0008155)2.63589544
32Urinary glycosaminoglycan excretion (HP:0003541)2.63589544
33Abnormality of glycolipid metabolism (HP:0010969)2.57362672
34Abnormality of liposaccharide metabolism (HP:0010968)2.57362672
35Abnormality of glycosphingolipid metabolism (HP:0004343)2.57362672
36Orchitis (HP:0100796)2.54690993
37Cervical subluxation (HP:0003308)2.53359904
38Disinhibition (HP:0000734)2.52801352
39Amyloidosis (HP:0011034)2.46937554
40Purpura (HP:0000979)2.40134238
41Abnormality of mucopolysaccharide metabolism (HP:0011020)2.40083367
42Abnormality of polysaccharide metabolism (HP:0011012)2.40083367
43Abnormality of glycosaminoglycan metabolism (HP:0004371)2.40083367
44Recurrent viral infections (HP:0004429)2.36389852
45Petechiae (HP:0000967)2.35677745
46Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.34076448
47Agnosia (HP:0010524)2.33901262
48Osteomyelitis (HP:0002754)2.32823260
49Chronic otitis media (HP:0000389)2.30087488
50Nausea (HP:0002018)2.28337555
51Reticulocytosis (HP:0001923)2.26992214
52Peritonitis (HP:0002586)2.25618220
53Multiple enchondromatosis (HP:0005701)2.25396924
54Stomatitis (HP:0010280)2.24295904
55Myocardial infarction (HP:0001658)2.24271828
56Apathy (HP:0000741)2.24123398
57Polycythemia (HP:0001901)2.22423021
58Hepatosplenomegaly (HP:0001433)2.21677183
59Nuclear cataract (HP:0100018)2.19071019
60Cholelithiasis (HP:0001081)2.17893982
61Spastic diplegia (HP:0001264)2.17046498
62Leukocytosis (HP:0001974)2.12145113
63Thrombocytosis (HP:0001894)2.03876843
64Skin ulcer (HP:0200042)2.02519050
65Prolonged bleeding time (HP:0003010)1.99541412
66Amaurosis fugax (HP:0100576)1.98051693
67Loss of speech (HP:0002371)1.96847808
68Orthostatic hypotension (HP:0001278)1.95963095
69Vasculitis (HP:0002633)1.95755728
70Hematochezia (HP:0002573)1.93351027
71Progressive neurologic deterioration (HP:0002344)1.92984767
72Vertebral compression fractures (HP:0002953)1.92879332
73Poor head control (HP:0002421)1.92805765
74Tetraparesis (HP:0002273)1.91341657
75Cerebral aneurysm (HP:0004944)1.90884869
76Meningitis (HP:0001287)1.90878389
77Basal ganglia calcification (HP:0002135)1.90320656
78Thoracic kyphosis (HP:0002942)1.89610812
79Mutism (HP:0002300)1.89122900
80Metaphyseal cupping (HP:0003021)1.89057741
81Abnormal gallbladder morphology (HP:0012437)1.87543281
82Hypertensive crisis (HP:0100735)1.86036147
83Neuronal loss in central nervous system (HP:0002529)1.85692484
84Increased serum ferritin (HP:0003281)1.85479996
85Rough bone trabeculation (HP:0100670)1.85373493
86Cheilitis (HP:0100825)1.85205409
87Increased mean platelet volume (HP:0011877)1.84186977
88IgM deficiency (HP:0002850)1.84180109
89Spontaneous hematomas (HP:0007420)1.83046936
90Hyperacusis (HP:0010780)1.82968977
91Hand muscle atrophy (HP:0009130)1.80931352
92Ulnar bowing (HP:0003031)1.80483925
93Pathologic fracture (HP:0002756)1.80420157
94Eosinophilia (HP:0001880)1.79480190
95Epistaxis (HP:0000421)1.79319207
96Cerebral inclusion bodies (HP:0100314)1.78398646
97Abnormality of the gallbladder (HP:0005264)1.76980849
98Premature rupture of membranes (HP:0001788)1.76621987
99Progressive external ophthalmoplegia (HP:0000590)1.75906281
100Polygenic inheritance (HP:0010982)1.75826797
101Abnormality of reticulocytes (HP:0004312)1.75432053
102Granulocytopenia (HP:0001913)1.75109625
103Increased density of long bones (HP:0006392)1.74519186
104Abnormal platelet volume (HP:0011876)1.73566657
105Disproportionate tall stature (HP:0001519)1.73361442
106Abnormality of the vasculature of the conjunctiva (HP:0008054)1.72568681
107Premature loss of primary teeth (HP:0006323)1.72506403
108Ankle contracture (HP:0006466)1.72292797
109Impaired platelet aggregation (HP:0003540)1.71367851
110Gingival bleeding (HP:0000225)1.70984641
111Personality changes (HP:0000751)1.70248882
112Nasal polyposis (HP:0100582)1.69617545
113Neurofibrillary tangles (HP:0002185)1.68882149
114Abnormality of the thoracic spine (HP:0100711)1.68600252
115Abnormality of the lumbar spine (HP:0100712)1.68547916
116Upper motor neuron abnormality (HP:0002127)1.67782473
117Hypertriglyceridemia (HP:0002155)1.66741628
118Pulmonary infiltrates (HP:0002113)1.66467812
119Recurrent pneumonia (HP:0006532)1.66091805
120Abnormal trabecular bone morphology (HP:0100671)1.66069231
121Abnormality of the nasal mucosa (HP:0000433)1.65661222
122Prolonged neonatal jaundice (HP:0006579)1.64755191
123Diminished motivation (HP:0000745)1.64582439
124Uterine leiomyosarcoma (HP:0002891)1.64038326
125Leiomyosarcoma (HP:0100243)1.64038326
126Recurrent lower respiratory tract infections (HP:0002783)1.63587062
127Increased IgE level (HP:0003212)1.63391047
128Elevated alkaline phosphatase (HP:0003155)1.62690308
129Chest pain (HP:0100749)1.62204534
130Abnormality of glycolysis (HP:0004366)1.62094994
131Abnormality of T cell physiology (HP:0011840)1.61739868
132Chronic mucocutaneous candidiasis (HP:0002728)1.61298235
133Recurrent cutaneous fungal infections (HP:0011370)1.61298235
134Long palpebral fissure (HP:0000637)1.61257004
135Peripheral demyelination (HP:0011096)1.61027794
136Neoplasm of head and neck (HP:0012288)1.60515411
137Esophageal neoplasm (HP:0100751)1.60515411
138Bone pain (HP:0002653)1.60351047
139Ragged-red muscle fibers (HP:0003200)1.59667458
140Arterial thrombosis (HP:0004420)1.59119625
141Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.59035530
142Nephritis (HP:0000123)1.58554966
143Abnormality of iron homeostasis (HP:0011031)1.57993265
144Abnormal platelet function (HP:0011869)1.57431483

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.51529363
2ERN13.30666648
3SMG13.05104035
4BLK2.76605231
5PKN22.52963145
6PRPF4B2.38798188
7IRAK42.33717640
8STK102.17820755
9IRAK32.04241307
10MAP4K12.00412986
11TBK11.88439555
12PIM21.81826388
13PAK41.81288506
14LRRK21.79508108
15TESK21.76952612
16TAOK21.75709782
17EEF2K1.74202563
18NME21.69739069
19TESK11.62778171
20TYK21.62194184
21RIPK41.60335367
22EPHB11.59927685
23ICK1.55114868
24RPS6KA41.54809517
25ZAP701.52817560
26EPHA21.46066457
27PTK61.44729243
28TTN1.44701922
29MAP2K31.43542126
30MST1R1.40562752
31CSK1.36890387
32KIT1.36355137
33CAMK1D1.35456077
34BUB11.35374056
35NEK21.35341046
36BMX1.33034866
37MAP3K111.32150107
38SRPK11.28793625
39MAP3K81.28192257
40MAP3K141.27200373
41WEE11.26335651
42BTK1.26137842
43CDK121.24357181
44JAK31.24137997
45RIPK11.22004989
46GRK61.11913213
47CSF1R1.09415457
48TRPM71.05614615
49FGFR41.04109090
50MAP3K101.03713443
51DYRK31.02614080
52PIM11.02009828
53IRAK20.99952938
54VRK20.99709133
55MATK0.98203836
56DDR20.97939242
57YES10.96388251
58ALK0.95800842
59CDK60.94629876
60MAP3K30.93319523
61IKBKB0.93054635
62HCK0.92754833
63CDK40.90578878
64TAOK30.89851136
65FLT30.89203711
66PBK0.88622986
67KDR0.88367726
68SIK30.87556732
69MAP3K10.86994678
70KSR10.84421894
71FGR0.83218577
72CDK70.82867047
73TEC0.81676341
74MAP3K60.80210158
75TGFBR20.79491549
76ARAF0.78908161
77SIK10.78378829
78TSSK60.78184561
79PRKG20.77741593
80MAP2K20.75599968
81PDK20.74721704
82IKBKE0.74662048
83STK30.74469911
84NEK90.71984399
85ERBB40.71942018
86RPS6KB20.71850612
87SCYL20.71468242
88LATS20.71419921
89MOS0.71306891
90EIF2AK10.69912461
91STK40.69635573
92ABL20.69093332
93MAP3K130.68104030
94JAK10.66091782
95PDGFRA0.65673185
96CDC42BPA0.64754730
97PAK10.64560160
98LYN0.64552866
99SYK0.63135585
100MST40.62997360
101KSR20.62766392
102JAK20.62316552
103FES0.59648265
104LCK0.59110661
105PTK20.57413752
106CHUK0.56679122
107MKNK10.56551771
108CDC70.55219626
109ILK0.53691177
110CAMK1G0.53629613
111RAF10.52103074
112PDPK10.51268722
113CLK10.50837725
114TTK0.50486640
115MAP3K50.50451026
116EGFR0.48654968
117MAPKAPK20.48619879
118CDK90.48295935
119GRK70.48230016
120MET0.48205294
121BRSK20.47085994
122NEK10.46761034
123MTOR0.45743038
124TAOK10.44965085
125BRAF0.44914821
126MARK30.44588968
127CHEK20.42948651
128ABL10.42852021
129MAPKAPK30.42505604
130LIMK10.41804231
131RPS6KL10.41621367
132RPS6KC10.41621367
133CDK140.40854022
134TAF10.40637070

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051402.89769111
2Legionellosis_Homo sapiens_hsa051342.26632116
3Staphylococcus aureus infection_Homo sapiens_hsa051502.23622633
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.20748453
5Lysosome_Homo sapiens_hsa041422.05068929
6Glycosaminoglycan degradation_Homo sapiens_hsa005311.93250109
7Other glycan degradation_Homo sapiens_hsa005111.88016359
8Osteoclast differentiation_Homo sapiens_hsa043801.85867356
9Toll-like receptor signaling pathway_Homo sapiens_hsa046201.80519924
10DNA replication_Homo sapiens_hsa030301.77246710
11Pertussis_Homo sapiens_hsa051331.71918885
12Tuberculosis_Homo sapiens_hsa051521.70414767
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.62852878
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.53838531
15Shigellosis_Homo sapiens_hsa051311.52063874
16NOD-like receptor signaling pathway_Homo sapiens_hsa046211.50089282
17Malaria_Homo sapiens_hsa051441.47897418
18Steroid biosynthesis_Homo sapiens_hsa001001.46339205
19Apoptosis_Homo sapiens_hsa042101.44984548
20Leukocyte transendothelial migration_Homo sapiens_hsa046701.43666206
21Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.43408073
22Biosynthesis of amino acids_Homo sapiens_hsa012301.41021081
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38123763
24Antigen processing and presentation_Homo sapiens_hsa046121.37654305
25Caffeine metabolism_Homo sapiens_hsa002321.35859780
26Salmonella infection_Homo sapiens_hsa051321.34882117
27Toxoplasmosis_Homo sapiens_hsa051451.33486883
28Phagosome_Homo sapiens_hsa041451.33438809
29Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.32592435
30Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.31597144
31Measles_Homo sapiens_hsa051621.27496669
32Influenza A_Homo sapiens_hsa051641.23760657
33TNF signaling pathway_Homo sapiens_hsa046681.22447403
34B cell receptor signaling pathway_Homo sapiens_hsa046621.22029421
35Asthma_Homo sapiens_hsa053101.20280567
36* Pentose phosphate pathway_Homo sapiens_hsa000301.19644362
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.19195528
38Sulfur relay system_Homo sapiens_hsa041221.18581945
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.17885362
40Herpes simplex infection_Homo sapiens_hsa051681.16264148
41Proteasome_Homo sapiens_hsa030501.15145095
42Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14252687
43Chronic myeloid leukemia_Homo sapiens_hsa052201.14215019
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11045149
45Hematopoietic cell lineage_Homo sapiens_hsa046401.10285245
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09748581
47Galactose metabolism_Homo sapiens_hsa000521.08794986
48Acute myeloid leukemia_Homo sapiens_hsa052211.06961991
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.06463761
50Hepatitis B_Homo sapiens_hsa051611.00537026
51One carbon pool by folate_Homo sapiens_hsa006700.96934731
52Mismatch repair_Homo sapiens_hsa034300.96179312
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95306869
54Base excision repair_Homo sapiens_hsa034100.94948593
55Vibrio cholerae infection_Homo sapiens_hsa051100.94508855
56Fructose and mannose metabolism_Homo sapiens_hsa000510.92881052
57Small cell lung cancer_Homo sapiens_hsa052220.92559455
58Renin-angiotensin system_Homo sapiens_hsa046140.90947501
59p53 signaling pathway_Homo sapiens_hsa041150.90799458
60Viral myocarditis_Homo sapiens_hsa054160.90219487
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.88678933
62Amoebiasis_Homo sapiens_hsa051460.87137821
63Notch signaling pathway_Homo sapiens_hsa043300.86858948
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86800492
65AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.86234342
66Graft-versus-host disease_Homo sapiens_hsa053320.86019965
67Non-small cell lung cancer_Homo sapiens_hsa052230.84924041
68Epstein-Barr virus infection_Homo sapiens_hsa051690.83840835
69Hepatitis C_Homo sapiens_hsa051600.82495541
70HIF-1 signaling pathway_Homo sapiens_hsa040660.82308586
71Bladder cancer_Homo sapiens_hsa052190.81634867
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.80333841
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.79886854
74Cell cycle_Homo sapiens_hsa041100.78490426
75Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77535153
76Prion diseases_Homo sapiens_hsa050200.77298196
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.76443651
78Rheumatoid arthritis_Homo sapiens_hsa053230.75273393
79Pancreatic cancer_Homo sapiens_hsa052120.75268116
80Folate biosynthesis_Homo sapiens_hsa007900.74811153
81Fatty acid elongation_Homo sapiens_hsa000620.74182874
82Renal cell carcinoma_Homo sapiens_hsa052110.73087823
83RNA transport_Homo sapiens_hsa030130.70865069
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70802188
85Viral carcinogenesis_Homo sapiens_hsa052030.70690700
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.70609301
87Chemokine signaling pathway_Homo sapiens_hsa040620.66977430
88Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65886396
89Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.65821856
90Proteoglycans in cancer_Homo sapiens_hsa052050.64654105
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64047676
92Endometrial cancer_Homo sapiens_hsa052130.62826332
93Homologous recombination_Homo sapiens_hsa034400.60995436
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.59852080
95Colorectal cancer_Homo sapiens_hsa052100.59733499
96* Glutathione metabolism_Homo sapiens_hsa004800.59709035
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.57573805
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.56906283
99MicroRNAs in cancer_Homo sapiens_hsa052060.55322181
100* Carbon metabolism_Homo sapiens_hsa012000.55108986
101Fat digestion and absorption_Homo sapiens_hsa049750.54338495
102Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54075236
103Spliceosome_Homo sapiens_hsa030400.53738557
104VEGF signaling pathway_Homo sapiens_hsa043700.52883512
105HTLV-I infection_Homo sapiens_hsa051660.52788908
106Adherens junction_Homo sapiens_hsa045200.51546867
107Mineral absorption_Homo sapiens_hsa049780.51500458
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51323579
109Ribosome_Homo sapiens_hsa030100.51010184
110Endocytosis_Homo sapiens_hsa041440.50588406
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49415142
112Platelet activation_Homo sapiens_hsa046110.49352716
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48291661
114Allograft rejection_Homo sapiens_hsa053300.47470816
115Fatty acid biosynthesis_Homo sapiens_hsa000610.47240129
116Non-homologous end-joining_Homo sapiens_hsa034500.47079313
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46912191
118Pyruvate metabolism_Homo sapiens_hsa006200.46770224
119Thyroid cancer_Homo sapiens_hsa052160.46253816
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.46131934
121African trypanosomiasis_Homo sapiens_hsa051430.44455138
122mRNA surveillance pathway_Homo sapiens_hsa030150.42518901
123Collecting duct acid secretion_Homo sapiens_hsa049660.42069583
124Insulin signaling pathway_Homo sapiens_hsa049100.41339511
125Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.39219120
126Prostate cancer_Homo sapiens_hsa052150.36825963

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