ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.10626229
2	proteasome assembly (GO:0043248)	5.57659589
3	termination of RNA polymerase III transcription (GO:0006386)	4.67742029
4	transcription elongation from RNA polymerase III promoter (GO:0006385)	4.67742029
5	DNA double-strand break processing (GO:0000729)	4.64712128
6	rRNA modification (GO:0000154)	4.11782767
7	ubiquinone biosynthetic process (GO:0006744)	4.03818422
8	platelet dense granule organization (GO:0060155)	4.03473571
9	rRNA methylation (GO:0031167)	3.92173900
10	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.60773242
11	negative regulation of telomere maintenance (GO:0032205)	3.58114534
12	chaperone-mediated protein transport (GO:0072321)	3.56506938
13	nucleoside transmembrane transport (GO:1901642)	3.56152215
14	ubiquinone metabolic process (GO:0006743)	3.55701296
15	regulation of helicase activity (GO:0051095)	3.52891035
16	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.47756704
17	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.47232115
18	protein neddylation (GO:0045116)	3.47101333
19	regulation of mitochondrial translation (GO:0070129)	3.44691689
20	protein localization to cilium (GO:0061512)	3.44656407
21	piRNA metabolic process (GO:0034587)	3.43878493
22	protein polyglutamylation (GO:0018095)	3.43598255
23	purine nucleobase biosynthetic process (GO:0009113)	3.42518495
24	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.37753424
25	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.36947789
26	positive regulation of prostaglandin secretion (GO:0032308)	3.36674569
27	regulation of penile erection (GO:0060405)	3.36565760
28	protein-cofactor linkage (GO:0018065)	3.34810060
29	mitochondrial respiratory chain complex assembly (GO:0033108)	3.34050002
30	water-soluble vitamin biosynthetic process (GO:0042364)	3.32701297
31	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.30282549
32	protein complex biogenesis (GO:0070271)	3.26901516
33	regulation of cilium movement (GO:0003352)	3.19182016
34	histone H2A monoubiquitination (GO:0035518)	3.14526463
35	quinone biosynthetic process (GO:1901663)	3.14460308
36	histone exchange (GO:0043486)	3.11103524
37	folic acid-containing compound biosynthetic process (GO:0009396)	3.07202306
38	fusion of sperm to egg plasma membrane (GO:0007342)	3.07150913
39	ATP synthesis coupled proton transport (GO:0015986)	3.06009654
40	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.06009654
41	striatum development (GO:0021756)	3.03913218
42	nucleobase biosynthetic process (GO:0046112)	3.03333768
43	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.01750263
44	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.00598078
45	DNA catabolic process, exonucleolytic (GO:0000738)	2.99671245
46	chromatin remodeling at centromere (GO:0031055)	2.96788975
47	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.95752909
48	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.95752909
49	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.93723738
50	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.92163892
51	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.91570317
52	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.91570317
53	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.91570317
54	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.90538094
55	negative regulation of membrane potential (GO:0045837)	2.89865022
56	thrombin receptor signaling pathway (GO:0070493)	2.89266245
57	iron-sulfur cluster assembly (GO:0016226)	2.87448222
58	metallo-sulfur cluster assembly (GO:0031163)	2.87448222
59	regulation of B cell apoptotic process (GO:0002902)	2.85297379
60	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.84937381
61	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.84937381
62	CENP-A containing nucleosome assembly (GO:0034080)	2.83995695
63	iron coordination entity transport (GO:1901678)	2.81813433
64	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.81234479
65	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.80862831
66	negative regulation of ligase activity (GO:0051352)	2.80862831
67	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.80299852
68	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	2.79759447
69	phosphatidylethanolamine metabolic process (GO:0046337)	2.79260687
70	GMP metabolic process (GO:0046037)	2.78082790
71	sperm motility (GO:0030317)	2.76747676
72	regulation of cellular amino acid metabolic process (GO:0006521)	2.76639393
73	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.75109290
74	peptidyl-histidine modification (GO:0018202)	2.74588700
75	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.73790437
76	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.73790437
77	fucose catabolic process (GO:0019317)	2.72097854
78	L-fucose metabolic process (GO:0042354)	2.72097854
79	L-fucose catabolic process (GO:0042355)	2.72097854
80	histone H2A ubiquitination (GO:0033522)	2.71953050
81	heme transport (GO:0015886)	2.71811633
82	regulation of mitotic spindle checkpoint (GO:1903504)	2.70235618
83	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.70235618
84	sperm-egg recognition (GO:0035036)	2.69535836
85	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.68741284
86	regulation of meiosis I (GO:0060631)	2.67281968
87	regulation of prostaglandin secretion (GO:0032306)	2.66092089
88	DNA strand renaturation (GO:0000733)	2.65701059
89	mitotic cell cycle arrest (GO:0071850)	2.63551086
90	purine deoxyribonucleotide catabolic process (GO:0009155)	2.60815901
91	inositol phosphate dephosphorylation (GO:0046855)	2.59572409
92	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.59572409
93	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.59434215
94	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.59434215
95	NADH dehydrogenase complex assembly (GO:0010257)	2.59434215
96	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.59098777
97	DNA replication checkpoint (GO:0000076)	2.58636304
98	negative regulation of B cell apoptotic process (GO:0002903)	2.57970391
99	response to X-ray (GO:0010165)	2.51930759
100	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.51199679

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.82478421
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.89143828
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.25317465
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.18619115
5	VDR_22108803_ChIP-Seq_LS180_Human	3.17135028
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.09664661
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.06991917
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.06485575
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.93815867
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.81624558
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.75334990
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.63177286
13	IGF1R_20145208_ChIP-Seq_DFB_Human	2.45278559
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.36963157
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.35721696
16	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.33761775
17	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.22484747
18	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.20446936
19	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.04117080
20	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.95394287
21	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.94633380
22	IRF1_19129219_ChIP-ChIP_H3396_Human	1.84902717
23	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.84646108
24	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.82295022
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.76713324
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.76171934
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.75149571
28	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.74976669
29	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.74319072
30	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.73922935
31	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.70370803
32	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.68285432
33	EWS_26573619_Chip-Seq_HEK293_Human	1.65389400
34	ER_23166858_ChIP-Seq_MCF-7_Human	1.64924002
35	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.61785514
36	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.56367862
37	ELK1_19687146_ChIP-ChIP_HELA_Human	1.50524986
38	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.49309466
39	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.43263567
40	GBX2_23144817_ChIP-Seq_PC3_Human	1.40835448
41	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.36634598
42	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.34664748
43	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.32233150
44	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.30015154
45	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.29928357
46	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.29848914
47	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.29122424
48	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.29122424
49	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.28869757
50	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.28496882
51	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.27817752
52	FUS_26573619_Chip-Seq_HEK293_Human	1.27720467
53	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.26923621
54	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.26777503
55	SOX2_19829295_ChIP-Seq_ESCs_Human	1.25637520
56	NANOG_19829295_ChIP-Seq_ESCs_Human	1.25637520
57	P300_19829295_ChIP-Seq_ESCs_Human	1.25149496
58	GABP_19822575_ChIP-Seq_HepG2_Human	1.24525511
59	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.22231570
60	NCOR_22424771_ChIP-Seq_293T_Human	1.21844243
61	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.20965036
62	CBP_20019798_ChIP-Seq_JUKART_Human	1.20965036
63	AR_20517297_ChIP-Seq_VCAP_Human	1.20963158
64	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.19611800
65	TP53_22573176_ChIP-Seq_HFKS_Human	1.17096514
66	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.15289873
67	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.13613103
68	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.13498463
69	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.13286209
70	DCP1A_22483619_ChIP-Seq_HELA_Human	1.12936188
71	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.12842595
72	E2F7_22180533_ChIP-Seq_HELA_Human	1.12050877
73	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.11250013
74	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.09068997
75	NANOG_20526341_ChIP-Seq_ESCs_Human	1.04414505
76	HOXB7_26014856_ChIP-Seq_BT474_Human	1.04402930
77	MYC_19829295_ChIP-Seq_ESCs_Human	1.03816120
78	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.02252235
79	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.01191283
80	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.99163892
81	ERG_20517297_ChIP-Seq_VCAP_Human	0.98479850
82	ERA_21632823_ChIP-Seq_H3396_Human	0.97205311
83	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.96963904
84	STAT1_20625510_ChIP-Seq_HELA_Human	0.96739482
85	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.96406821
86	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.95638239
87	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.95436943
88	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.94626857
89	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.93257323
90	AR_25329375_ChIP-Seq_VCAP_Human	0.92677911
91	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.92608251
92	TAF2_19829295_ChIP-Seq_ESCs_Human	0.92571431
93	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.91208313
94	RAC3_21632823_ChIP-Seq_H3396_Human	0.90992504
95	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.90231667
96	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.89920439
97	AR_21572438_ChIP-Seq_LNCaP_Human	0.88724220
98	PHF8_20622853_ChIP-Seq_HELA_Human	0.88394803
99	TTF2_22483619_ChIP-Seq_HELA_Human	0.88171551
100	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.87218080

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	3.92821718
2	MP0000372_irregular_coat_pigmentation	3.61463489
3	MP0005084_abnormal_gallbladder_morpholo	3.40837470
4	MP0002102_abnormal_ear_morphology	3.05728102
5	MP0005410_abnormal_fertilization	2.97369048
6	MP0009697_abnormal_copulation	2.89065593
7	MP0005248_abnormal_Harderian_gland	2.88900833
8	MP0002282_abnormal_trachea_morphology	2.57188216
9	MP0010030_abnormal_orbit_morphology	2.52555611
10	MP0008058_abnormal_DNA_repair	2.48714485
11	MP0003718_maternal_effect	2.42861158
12	MP0006292_abnormal_olfactory_placode	2.41745627
13	MP0003646_muscle_fatigue	2.35332328
14	MP0003693_abnormal_embryo_hatching	2.34141740
15	MP0010094_abnormal_chromosome_stability	2.28904777
16	MP0008877_abnormal_DNA_methylation	2.14710392
17	MP0003195_calcinosis	2.05374632
18	MP0001968_abnormal_touch/_nociception	2.03492237
19	MP0006072_abnormal_retinal_apoptosis	1.99366414
20	MP0008872_abnormal_physiological_respon	1.98805545
21	MP0001529_abnormal_vocalization	1.97448270
22	MP0002736_abnormal_nociception_after	1.93284793
23	MP0010368_abnormal_lymphatic_system	1.91017458
24	MP0003880_abnormal_central_pattern	1.85597532
25	MP0008775_abnormal_heart_ventricle	1.84715779
26	MP0002938_white_spotting	1.83997474
27	MP0000678_abnormal_parathyroid_gland	1.83539042
28	MP0004885_abnormal_endolymph	1.75783025
29	MP0006036_abnormal_mitochondrial_physio	1.70082342
30	MP0003111_abnormal_nucleus_morphology	1.55191458
31	MP0003011_delayed_dark_adaptation	1.54922407
32	MP0004957_abnormal_blastocyst_morpholog	1.50931781
33	MP0001905_abnormal_dopamine_level	1.50197367
34	MP0006035_abnormal_mitochondrial_morpho	1.44742540
35	MP0002837_dystrophic_cardiac_calcinosis	1.44317267
36	MP0000613_abnormal_salivary_gland	1.41887849
37	MP0003186_abnormal_redox_activity	1.39194960
38	MP0005377_hearing/vestibular/ear_phenot	1.33800386
39	MP0003878_abnormal_ear_physiology	1.33800386
40	MP0001661_extended_life_span	1.33218730
41	MP0005646_abnormal_pituitary_gland	1.32718502
42	MP0001929_abnormal_gametogenesis	1.30912769
43	MP0002751_abnormal_autonomic_nervous	1.30351850
44	MP0003806_abnormal_nucleotide_metabolis	1.29577826
45	MP0005167_abnormal_blood-brain_barrier	1.25195548
46	MP0000647_abnormal_sebaceous_gland	1.17911477
47	MP0003786_premature_aging	1.16665278
48	MP0005253_abnormal_eye_physiology	1.15970596
49	MP0004133_heterotaxia	1.15100386
50	MP0005075_abnormal_melanosome_morpholog	1.15066419
51	MP0002234_abnormal_pharynx_morphology	1.14019594
52	MP0000230_abnormal_systemic_arterial	1.13048990
53	MP0003698_abnormal_male_reproductive	1.10948921
54	MP0005389_reproductive_system_phenotype	1.10773343
55	MP0002733_abnormal_thermal_nociception	1.10433772
56	MP0005083_abnormal_biliary_tract	1.10241989
57	MP0002160_abnormal_reproductive_system	1.05467926
58	MP0005319_abnormal_enzyme/_coenzyme	1.04918234
59	MP0005636_abnormal_mineral_homeostasis	1.03865126
60	MP0001727_abnormal_embryo_implantation	1.03402833
61	MP0008007_abnormal_cellular_replicative	1.01055677
62	MP0000653_abnormal_sex_gland	0.99586622
63	MP0001485_abnormal_pinna_reflex	0.98710727
64	MP0001293_anophthalmia	0.98665495
65	MP0001501_abnormal_sleep_pattern	0.98372903
66	MP0006276_abnormal_autonomic_nervous	0.95780029
67	MP0005395_other_phenotype	0.92214417
68	MP0002210_abnormal_sex_determination	0.91072882
69	MP0000427_abnormal_hair_cycle	0.90704577
70	MP0005332_abnormal_amino_acid	0.84520533
71	MP0008932_abnormal_embryonic_tissue	0.83577621
72	MP0001486_abnormal_startle_reflex	0.83470451
73	MP0002249_abnormal_larynx_morphology	0.82907364
74	MP0008875_abnormal_xenobiotic_pharmacok	0.81854401
75	MP0005085_abnormal_gallbladder_physiolo	0.81761309
76	MP0001145_abnormal_male_reproductive	0.80587906
77	MP0002138_abnormal_hepatobiliary_system	0.80314741
78	MP0005187_abnormal_penis_morphology	0.79675699
79	MP0001919_abnormal_reproductive_system	0.77552770
80	MP0005365_abnormal_bile_salt	0.77401865
81	MP0004145_abnormal_muscle_electrophysio	0.75144085
82	MP0005551_abnormal_eye_electrophysiolog	0.74269321
83	MP0004215_abnormal_myocardial_fiber	0.73627677
84	MP0008057_abnormal_DNA_replication	0.73620473
85	MP0002006_tumorigenesis	0.73444443
86	MP0005647_abnormal_sex_gland	0.73194030
87	MP0009765_abnormal_xenobiotic_induced	0.71111649
88	MP0008995_early_reproductive_senescence	0.68123146
89	MP0003119_abnormal_digestive_system	0.68063104
90	MP0003136_yellow_coat_color	0.67881183
91	MP0001188_hyperpigmentation	0.67735035
92	MP0002127_abnormal_cardiovascular_syste	0.67722473
93	MP0002557_abnormal_social/conspecific_i	0.67632086
94	MP0002132_abnormal_respiratory_system	0.66122069
95	MP0001286_abnormal_eye_development	0.65914076
96	MP0003252_abnormal_bile_duct	0.65811752
97	MP0001986_abnormal_taste_sensitivity	0.65763928
98	MP0001835_abnormal_antigen_presentation	0.64834136
99	MP0001119_abnormal_female_reproductive	0.64567431
100	MP0000538_abnormal_urinary_bladder	0.63920667

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Colon cancer (HP:0003003)	3.68280020
2	Acute necrotizing encephalopathy (HP:0006965)	3.42367002
3	Pancreatic cysts (HP:0001737)	3.26206720
4	Hypochromic microcytic anemia (HP:0004840)	3.06988470
5	Progressive inability to walk (HP:0002505)	3.04221352
6	Acute encephalopathy (HP:0006846)	3.01239599
7	Pancreatic fibrosis (HP:0100732)	2.99367650
8	Azoospermia (HP:0000027)	2.96728427
9	Increased CSF lactate (HP:0002490)	2.93390079
10	Mitochondrial inheritance (HP:0001427)	2.92170268
11	Prostate neoplasm (HP:0100787)	2.90792746
12	Abnormal mitochondria in muscle tissue (HP:0008316)	2.87580849
13	Progressive macrocephaly (HP:0004481)	2.81508546
14	Abnormal pancreas size (HP:0012094)	2.80421123
15	Tubular atrophy (HP:0000092)	2.79501151
16	Abnormal spermatogenesis (HP:0008669)	2.78780441
17	Reduced antithrombin III activity (HP:0001976)	2.78002163
18	Abnormality of the renal cortex (HP:0011035)	2.73195253
19	Testicular atrophy (HP:0000029)	2.71031119
20	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.63682637
21	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.63682637
22	Increased hepatocellular lipid droplets (HP:0006565)	2.61795946
23	Nephronophthisis (HP:0000090)	2.60357476
24	Exertional dyspnea (HP:0002875)	2.56550644
25	Abnormal lung lobation (HP:0002101)	2.56097936
26	Abolished electroretinogram (ERG) (HP:0000550)	2.53424868
27	Occipital encephalocele (HP:0002085)	2.51628563
28	Small intestinal stenosis (HP:0012848)	2.49793551
29	Duodenal stenosis (HP:0100867)	2.49793551
30	Annular pancreas (HP:0001734)	2.49195396
31	Renal Fanconi syndrome (HP:0001994)	2.47890022
32	Abnormality of dental color (HP:0011073)	2.46812732
33	Stomach cancer (HP:0012126)	2.45148753
34	Inability to walk (HP:0002540)	2.43783581
35	Facial diplegia (HP:0001349)	2.43260806
36	Mesangial abnormality (HP:0001966)	2.39011634
37	Abnormality of the costochondral junction (HP:0000919)	2.37254906
38	Abnormality of the renal medulla (HP:0100957)	2.36020659
39	Anophthalmia (HP:0000528)	2.35034617
40	White forelock (HP:0002211)	2.32321991
41	Amelogenesis imperfecta (HP:0000705)	2.31599373
42	Hepatocellular necrosis (HP:0001404)	2.30208046
43	True hermaphroditism (HP:0010459)	2.28983245
44	Attenuation of retinal blood vessels (HP:0007843)	2.27481787
45	Bicornuate uterus (HP:0000813)	2.26506276
46	Fibular aplasia (HP:0002990)	2.24516904
47	Cerebral edema (HP:0002181)	2.24135586
48	Abnormal biliary tract physiology (HP:0012439)	2.23824723
49	Bile duct proliferation (HP:0001408)	2.23824723
50	Hepatic necrosis (HP:0002605)	2.21407647
51	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.20933646
52	Abnormality of alanine metabolism (HP:0010916)	2.20933646
53	Hyperalaninemia (HP:0003348)	2.20933646
54	Retinal dysplasia (HP:0007973)	2.20735478
55	Increased serum lactate (HP:0002151)	2.20104749
56	Abnormal drinking behavior (HP:0030082)	2.18831798
57	Polydipsia (HP:0001959)	2.18831798
58	Methylmalonic acidemia (HP:0002912)	2.17014942
59	Lipid accumulation in hepatocytes (HP:0006561)	2.15128787
60	Type II lissencephaly (HP:0007260)	2.14842990
61	Sclerocornea (HP:0000647)	2.12087801
62	Abnormality of the prostate (HP:0008775)	2.09758223
63	Abnormality of midbrain morphology (HP:0002418)	2.08952116
64	Molar tooth sign on MRI (HP:0002419)	2.08952116
65	Pendular nystagmus (HP:0012043)	2.05693291
66	Lactic acidosis (HP:0003128)	2.04438789
67	Polyuria (HP:0000103)	2.02547808
68	Postaxial foot polydactyly (HP:0001830)	2.01758104
69	Patchy hypopigmentation of hair (HP:0011365)	2.00520446
70	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.99585432
71	Meckel diverticulum (HP:0002245)	1.99421305
72	Agnosia (HP:0010524)	1.99035533
73	Abnormal rod and cone electroretinograms (HP:0008323)	1.97420836
74	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.97134206
75	Hyperglycinuria (HP:0003108)	1.96723260
76	Abnormality of the labia minora (HP:0012880)	1.96312762
77	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.96157988
78	Abnormality of the duodenum (HP:0002246)	1.95016779
79	Ependymoma (HP:0002888)	1.89117150
80	Methylmalonic aciduria (HP:0012120)	1.88473865
81	Rough bone trabeculation (HP:0100670)	1.88058788
82	Abnormal protein glycosylation (HP:0012346)	1.87849308
83	Abnormal glycosylation (HP:0012345)	1.87849308
84	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.87849308
85	Abnormal protein N-linked glycosylation (HP:0012347)	1.87849308
86	Abnormality of the ileum (HP:0001549)	1.86202603
87	Abnormal respiratory motile cilium morphology (HP:0005938)	1.83953238
88	Abnormal respiratory epithelium morphology (HP:0012253)	1.83953238
89	Premature loss of primary teeth (HP:0006323)	1.82658265
90	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.82027009
91	Absent/shortened dynein arms (HP:0200106)	1.80010058
92	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.80010058
93	Abnormality of the middle phalanges of the toes (HP:0010183)	1.79835078
94	IgG deficiency (HP:0004315)	1.79385841
95	Breast carcinoma (HP:0003002)	1.77569549
96	Symptomatic seizures (HP:0011145)	1.77115240
97	Neoplasm of the adrenal gland (HP:0100631)	1.74312734
98	Abnormal urine output (HP:0012590)	1.73836020
99	Glycosuria (HP:0003076)	1.72139018
100	Abnormality of urine glucose concentration (HP:0011016)	1.72139018

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	4.66258328
2	NUAK1	4.00676144
3	EIF2AK1	3.47564884
4	TIE1	3.15617629
5	EIF2AK3	3.04858537
6	PLK4	2.40253940
7	ZAK	2.34798605
8	GRK1	2.18241970
9	TAF1	2.00759514
10	FRK	2.00452417
11	MAP4K2	2.00093159
12	TNIK	1.96918533
13	OXSR1	1.92660421
14	SRPK1	1.84776194
15	STK39	1.83395210
16	MATK	1.75503693
17	WNK4	1.75071188
18	PLK2	1.74412053
19	CSNK1G3	1.74095472
20	PLK3	1.73348363
21	NME2	1.69310258
22	ACVR1B	1.69261954
23	BMPR1B	1.67110371
24	VRK1	1.60906261
25	INSRR	1.60902195
26	EIF2AK2	1.59246087
27	CSNK1G2	1.54506023
28	MKNK2	1.52725852
29	WNK3	1.50833362
30	ADRBK2	1.49612932
31	TSSK6	1.44794093
32	CSNK1G1	1.43049265
33	CDK19	1.41133671
34	GRK5	1.37603783
35	BCKDK	1.29652621
36	MAPKAPK3	1.25341183
37	TAOK3	1.22158918
38	MKNK1	1.21767977
39	MST4	1.18469044
40	TRIM28	1.14565353
41	CSNK1A1L	1.13856076
42	PINK1	1.11707366
43	GRK7	1.11658370
44	TLK1	1.08457725
45	TTK	1.04141538
46	NEK9	1.03397700
47	SCYL2	0.97303735
48	TEC	0.93841012
49	PBK	0.92616341
50	PDK2	0.89669403
51	IKBKB	0.88547416
52	BRSK1	0.88073226
53	MAPKAPK5	0.87924095
54	GRK6	0.86141471
55	PLK1	0.83948976
56	BRSK2	0.79033698
57	DYRK2	0.76686102
58	PIK3CG	0.74472125
59	MAP2K2	0.74082675
60	SMG1	0.70363801
61	PTK2B	0.67339501
62	TBK1	0.62290887
63	DAPK1	0.59516020
64	MAPK13	0.58208554
65	CDK7	0.57168825
66	NEK1	0.54334051
67	ATR	0.50764962
68	IKBKE	0.50348757
69	CHEK2	0.48126529
70	WEE1	0.47728008
71	TESK1	0.47171244
72	LIMK1	0.45593716
73	STK4	0.44086939
74	ADRBK1	0.43736610
75	NME1	0.43163796
76	MAP3K14	0.42427571
77	CSNK1A1	0.42295304
78	ATM	0.41156182
79	CSNK2A1	0.38023693
80	IGF1R	0.36903713
81	PRKCG	0.35088981
82	SYK	0.34455291
83	AURKA	0.33349710
84	CAMKK2	0.32397211
85	PRKAA2	0.32317125
86	CCNB1	0.31652693
87	ERBB3	0.31596128
88	DDR2	0.30949513
89	NEK2	0.30777738
90	PHKG2	0.30147654
91	PHKG1	0.30147654
92	CHEK1	0.29908592
93	MAP3K4	0.29907905
94	NTRK1	0.29907093
95	CSNK2A2	0.29813635
96	TGFBR1	0.29704913
97	KIT	0.29445325
98	TRPM7	0.28004425
99	AURKB	0.27483175
100	BCR	0.26442615

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.92510318
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.99440609
3	RNA polymerase_Homo sapiens_hsa03020	2.94382335
4	Homologous recombination_Homo sapiens_hsa03440	2.60196537
5	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.56000213
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.52793805
7	Mismatch repair_Homo sapiens_hsa03430	2.45080942
8	Parkinsons disease_Homo sapiens_hsa05012	2.39857731
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.38056954
10	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.36094932
11	Selenocompound metabolism_Homo sapiens_hsa00450	2.11658103
12	DNA replication_Homo sapiens_hsa03030	2.09074885
13	Base excision repair_Homo sapiens_hsa03410	2.09074237
14	Protein export_Homo sapiens_hsa03060	2.05108370
15	Pyrimidine metabolism_Homo sapiens_hsa00240	1.98262918
16	One carbon pool by folate_Homo sapiens_hsa00670	1.95223043
17	RNA transport_Homo sapiens_hsa03013	1.75554169
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.68518099
19	Propanoate metabolism_Homo sapiens_hsa00640	1.65238905
20	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.63802161
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.62974622
22	Sulfur relay system_Homo sapiens_hsa04122	1.57816498
23	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.56655481
24	RNA degradation_Homo sapiens_hsa03018	1.55894211
25	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.55699648
26	Non-homologous end-joining_Homo sapiens_hsa03450	1.51461836
27	Purine metabolism_Homo sapiens_hsa00230	1.48096512
28	Huntingtons disease_Homo sapiens_hsa05016	1.43592240
29	Folate biosynthesis_Homo sapiens_hsa00790	1.42602173
30	Nucleotide excision repair_Homo sapiens_hsa03420	1.42048274
31	Tryptophan metabolism_Homo sapiens_hsa00380	1.34811388
32	Butanoate metabolism_Homo sapiens_hsa00650	1.31153960
33	Basal transcription factors_Homo sapiens_hsa03022	1.27360590
34	Fatty acid elongation_Homo sapiens_hsa00062	1.26057982
35	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.24723062
36	Pyruvate metabolism_Homo sapiens_hsa00620	1.19600261
37	Spliceosome_Homo sapiens_hsa03040	1.19062743
38	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.16571943
39	Phototransduction_Homo sapiens_hsa04744	1.16062863
40	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.12990444
41	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.12443788
42	Alzheimers disease_Homo sapiens_hsa05010	1.12165965
43	Asthma_Homo sapiens_hsa05310	1.11702351
44	Nitrogen metabolism_Homo sapiens_hsa00910	1.02156722
45	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.96577239
46	Steroid biosynthesis_Homo sapiens_hsa00100	0.94752837
47	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.94449465
48	Ribosome_Homo sapiens_hsa03010	0.94365926
49	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.94008323
50	Fatty acid degradation_Homo sapiens_hsa00071	0.90846257
51	Collecting duct acid secretion_Homo sapiens_hsa04966	0.89816917
52	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.89525635
53	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.88701248
54	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.86249455
55	Regulation of autophagy_Homo sapiens_hsa04140	0.81638843
56	Metabolic pathways_Homo sapiens_hsa01100	0.80979146
57	Sulfur metabolism_Homo sapiens_hsa00920	0.78481102
58	Carbon metabolism_Homo sapiens_hsa01200	0.75045784
59	Rheumatoid arthritis_Homo sapiens_hsa05323	0.73656394
60	ABC transporters_Homo sapiens_hsa02010	0.72147375
61	Caffeine metabolism_Homo sapiens_hsa00232	0.70086767
62	beta-Alanine metabolism_Homo sapiens_hsa00410	0.68260162
63	p53 signaling pathway_Homo sapiens_hsa04115	0.67821899
64	Linoleic acid metabolism_Homo sapiens_hsa00591	0.67438740
65	Fatty acid metabolism_Homo sapiens_hsa01212	0.67248445
66	Arginine and proline metabolism_Homo sapiens_hsa00330	0.66165205
67	Peroxisome_Homo sapiens_hsa04146	0.65253732
68	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.65174806
69	Glutathione metabolism_Homo sapiens_hsa00480	0.64572041
70	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.64157241
71	Fat digestion and absorption_Homo sapiens_hsa04975	0.61400918
72	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.58845830
73	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.58591843
74	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.58079311
75	Glycerolipid metabolism_Homo sapiens_hsa00561	0.58031418
76	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.57154887
77	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.57069944
78	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.56468539
79	Olfactory transduction_Homo sapiens_hsa04740	0.56200477
80	Ether lipid metabolism_Homo sapiens_hsa00565	0.53572134
81	Allograft rejection_Homo sapiens_hsa05330	0.48759411
82	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.47980032
83	mRNA surveillance pathway_Homo sapiens_hsa03015	0.46121362
84	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.44186812
85	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.43801538
86	Mineral absorption_Homo sapiens_hsa04978	0.43702787
87	Retinol metabolism_Homo sapiens_hsa00830	0.43405912
88	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.42666651
89	Taste transduction_Homo sapiens_hsa04742	0.38238902
90	Legionellosis_Homo sapiens_hsa05134	0.38087988
91	Cardiac muscle contraction_Homo sapiens_hsa04260	0.37844095
92	Graft-versus-host disease_Homo sapiens_hsa05332	0.37410409
93	Oocyte meiosis_Homo sapiens_hsa04114	0.36179417
94	Serotonergic synapse_Homo sapiens_hsa04726	0.35288915
95	Type I diabetes mellitus_Homo sapiens_hsa04940	0.34884662
96	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.34602830
97	Chemical carcinogenesis_Homo sapiens_hsa05204	0.34549958
98	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.33128286
99	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.32752551
100	Pentose phosphate pathway_Homo sapiens_hsa00030	0.29768791

PGDP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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