PGF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1endocrine hormone secretion (GO:0060986)9.46594132
2bone trabecula formation (GO:0060346)8.07315221
3negative regulation of blood vessel endothelial cell migration (GO:0043537)8.03144728
4endothelial cell proliferation (GO:0001935)7.63786026
5activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)7.36706949
6estrogen biosynthetic process (GO:0006703)7.29212903
7wound healing, spreading of epidermal cells (GO:0035313)6.63852440
8lymphangiogenesis (GO:0001946)6.56881603
9negative regulation of endothelial cell migration (GO:0010596)5.61370820
10Golgi transport vesicle coating (GO:0048200)5.59490003
11COPI coating of Golgi vesicle (GO:0048205)5.59490003
12cellular copper ion homeostasis (GO:0006878)5.28517131
13positive regulation of blood vessel endothelial cell migration (GO:0043536)5.16693838
14thyroid gland development (GO:0030878)5.11394669
15morphogenesis of an endothelium (GO:0003159)4.73158735
16endothelial tube morphogenesis (GO:0061154)4.73158735
17basement membrane organization (GO:0071711)4.59347035
18wound healing, spreading of cells (GO:0044319)4.50444425
19syncytium formation (GO:0006949)4.46492863
20regulation of blood vessel endothelial cell migration (GO:0043535)4.43787247
21endodermal cell differentiation (GO:0035987)4.32704759
22regulation of somitogenesis (GO:0014807)4.30745600
23positive regulation of hair follicle development (GO:0051798)4.28884804
24positive regulation of hair cycle (GO:0042635)4.28884804
25angiogenesis involved in wound healing (GO:0060055)4.28358539
26response to follicle-stimulating hormone (GO:0032354)4.22536955
27lung vasculature development (GO:0060426)4.18048631
28positive regulation of calcium ion import (GO:0090280)4.08612820
29negative regulation of epithelial cell migration (GO:0010633)4.06790784
30trabecula formation (GO:0060343)4.05736109
31protein heterotrimerization (GO:0070208)4.02103991
32vascular endothelial growth factor signaling pathway (GO:0038084)3.95160783
33maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.94201511
34endocardial cushion morphogenesis (GO:0003203)3.93434615
35sequestering of metal ion (GO:0051238)3.90993324
36negative regulation of organ growth (GO:0046621)3.90231289
37copper ion homeostasis (GO:0055070)3.86168369
38* sprouting angiogenesis (GO:0002040)3.75209117
39protein retention in ER lumen (GO:0006621)3.68068115
40desmosome organization (GO:0002934)3.63630496
41ER overload response (GO:0006983)3.60886067
42tooth mineralization (GO:0034505)3.59498358
43atrioventricular valve morphogenesis (GO:0003181)3.58650026
44glomerulus development (GO:0032835)3.55341811
45positive regulation of endothelial cell migration (GO:0010595)3.54301320
46cell proliferation involved in kidney development (GO:0072111)3.54017583
47anatomical structure maturation (GO:0071695)3.44199637
48metanephric mesenchyme development (GO:0072075)3.43663676
49cell proliferation involved in metanephros development (GO:0072203)3.40671923
50negative regulation of activin receptor signaling pathway (GO:0032926)3.36894526
51mesenchyme morphogenesis (GO:0072132)3.35446659
52adhesion of symbiont to host cell (GO:0044650)3.34129263
53virion attachment to host cell (GO:0019062)3.34129263
54glomerular filtration (GO:0003094)3.30796179
55cardiac epithelial to mesenchymal transition (GO:0060317)3.28176819
56epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.26512033
57regulation of hair follicle development (GO:0051797)3.25612319
58retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.25326534
59bundle of His cell to Purkinje myocyte communication (GO:0086069)3.21822301
60chondrocyte proliferation (GO:0035988)3.21601689
61peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.21114470
62cell surface receptor signaling pathway involved in heart development (GO:0061311)3.19521730
63negative regulation of nitric-oxide synthase activity (GO:0051001)3.17856949
64mesenchymal cell differentiation involved in kidney development (GO:0072161)3.15951130
65mesenchymal cell differentiation involved in renal system development (GO:2001012)3.15951130
66ganglion development (GO:0061548)3.15885181
67regulation of endothelial cell migration (GO:0010594)3.13804475
68regulation of secondary heart field cardioblast proliferation (GO:0003266)3.13792350
69regulation of cardioblast proliferation (GO:0003264)3.13792350
70renal filtration (GO:0097205)3.13355662
71cell migration involved in heart development (GO:0060973)3.11468417
72thyroid hormone generation (GO:0006590)3.09948576
73cell differentiation involved in metanephros development (GO:0072202)3.09760348
74kidney mesenchyme development (GO:0072074)3.09265896
75regulation of integrin-mediated signaling pathway (GO:2001044)3.08833610
76Notch signaling involved in heart development (GO:0061314)3.08303737
77adhesion of symbiont to host (GO:0044406)3.04662681
78hyaluronan catabolic process (GO:0030214)3.03976688
79pattern specification involved in kidney development (GO:0061004)3.03824737
80vascular smooth muscle contraction (GO:0014829)3.03242772
81lymph vessel development (GO:0001945)3.02788235
82estrogen metabolic process (GO:0008210)3.01736561
83sphingosine metabolic process (GO:0006670)3.01608632
84negative regulation of catenin import into nucleus (GO:0035414)2.98099621
85negative regulation of angiogenesis (GO:0016525)2.97714103
86endothelial cell morphogenesis (GO:0001886)2.96434790
87positive regulation of protein kinase C signaling (GO:0090037)2.95872851
88polarized epithelial cell differentiation (GO:0030859)2.95624383
89sphingoid metabolic process (GO:0046519)2.94784803
90cytoskeletal anchoring at plasma membrane (GO:0007016)2.93864672
91positive regulation of endothelial cell differentiation (GO:0045603)2.92520273
92negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.91126400
93regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.89248424
94tonic smooth muscle contraction (GO:0014820)2.88610168
95endothelium development (GO:0003158)2.87295924
96extracellular matrix assembly (GO:0085029)2.87079008
97vitamin transmembrane transport (GO:0035461)2.84951031
98positive regulation of metanephros development (GO:0072216)2.84949627
99negative regulation of blood vessel morphogenesis (GO:2000181)2.84206695
100negative regulation of platelet activation (GO:0010544)2.83399740
101* angiogenesis (GO:0001525)2.80660911
102positive regulation of meiotic cell cycle (GO:0051446)2.79778743
103* female pregnancy (GO:0007565)2.79450401
104regulation of G0 to G1 transition (GO:0070316)2.79346226
105cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.78686525
106* vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.78200493
107negative regulation of chondrocyte differentiation (GO:0032331)2.78071773
108L-alpha-amino acid transmembrane transport (GO:1902475)2.77732081
109artery smooth muscle contraction (GO:0014824)2.76790184
110cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.75717152
111outflow tract septum morphogenesis (GO:0003148)2.75028612
112patterning of blood vessels (GO:0001569)2.74102920
113retina vasculature morphogenesis in camera-type eye (GO:0061299)2.73589012
114negative regulation of cell junction assembly (GO:1901889)2.73037944
115negative regulation of adherens junction organization (GO:1903392)2.73037944
116negative regulation of focal adhesion assembly (GO:0051895)2.73037944
117cranial suture morphogenesis (GO:0060363)2.72978769
118branching involved in salivary gland morphogenesis (GO:0060445)2.71622723
119peptide hormone processing (GO:0016486)2.70697644
120positive regulation of odontogenesis (GO:0042482)2.70384682
121ureteric bud development (GO:0001657)2.68879615
122venous blood vessel morphogenesis (GO:0048845)2.68207786
123keratinocyte development (GO:0003334)2.67776864
124craniofacial suture morphogenesis (GO:0097094)2.67602232
125female genitalia development (GO:0030540)2.67306689
126negative regulation of vasculature development (GO:1901343)2.66981699
127endothelial cell differentiation (GO:0045446)2.66157932
128positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.64514018
129protein kinase C signaling (GO:0070528)2.64448482
130regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.64111415
131surfactant homeostasis (GO:0043129)2.64009180
132embryonic heart tube development (GO:0035050)2.63613937
133exocrine pancreas development (GO:0031017)2.63269529
134response to gonadotropin (GO:0034698)2.63003343
135epithelial cell proliferation (GO:0050673)2.62518396
136semaphorin-plexin signaling pathway (GO:0071526)2.61700840
137mesonephric tubule development (GO:0072164)2.60697243
138decidualization (GO:0046697)2.59766096
139respiratory tube development (GO:0030323)2.58305786
140regulation of calcium ion import (GO:0090279)2.57172310
141mesodermal cell differentiation (GO:0048333)2.56649494
142mesenchymal cell development (GO:0014031)2.56269103
143positive regulation of endothelial cell apoptotic process (GO:2000353)2.55865098
144mesonephric epithelium development (GO:0072163)2.55442159
145nucleoside diphosphate catabolic process (GO:0009134)2.54392760
146negative regulation of stem cell proliferation (GO:2000647)2.53808246
147signal peptide processing (GO:0006465)2.52010114
148regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.51072796
149activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.51034385
150response to copper ion (GO:0046688)2.50419812
151COPII vesicle coating (GO:0048208)2.49976275
152cellular extravasation (GO:0045123)2.47597538
153cGMP-mediated signaling (GO:0019934)2.44898346
154collagen fibril organization (GO:0030199)2.42923603
155protein maturation by protein folding (GO:0022417)2.41992368
156cellular zinc ion homeostasis (GO:0006882)2.41038157
157regulation of penile erection (GO:0060405)2.40159607
158coronary vasculature morphogenesis (GO:0060977)2.38565266
159type B pancreatic cell development (GO:0003323)2.38261578
160regulation of endothelial cell differentiation (GO:0045601)2.38064927
161positive regulation of glycogen biosynthetic process (GO:0045725)2.37715819
162endocrine pancreas development (GO:0031018)2.36797592
163thyroid hormone metabolic process (GO:0042403)2.36705981
164vesicle coating (GO:0006901)2.36551830
165negative regulation of cartilage development (GO:0061037)2.36505986
166vasculature development (GO:0001944)2.36004273
167epithelial cell fate commitment (GO:0072148)2.35257598
168hemidesmosome assembly (GO:0031581)2.34923282
169response to progesterone (GO:0032570)2.34595197
170positive regulation of nuclease activity (GO:0032075)2.34425859
171regulation of metanephros development (GO:0072215)2.33593127
172endocardial cushion development (GO:0003197)2.33338248
173glomerular basement membrane development (GO:0032836)2.33106618
174L-serine transport (GO:0015825)2.32318535
175copper ion transport (GO:0006825)2.32134049
176negative regulation of smooth muscle cell migration (GO:0014912)2.29803036
177lung morphogenesis (GO:0060425)2.29319163
178regulation of positive chemotaxis (GO:0050926)2.29313532
179induction of positive chemotaxis (GO:0050930)2.29291058
180peptide catabolic process (GO:0043171)2.28771934
181nitric oxide mediated signal transduction (GO:0007263)2.28565337
182blood vessel maturation (GO:0001955)10.0995874

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.50002164
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.05464940
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human4.05135495
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.39500991
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.05984767
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.99694884
7CLOCK_20551151_ChIP-Seq_293T_Human2.92579777
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.89398326
9ELK3_25401928_ChIP-Seq_HUVEC_Human2.73687098
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.43609897
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.39283709
12* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.37503390
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.37281735
14TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.25532747
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.23087091
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.20476580
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.19954742
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.14667277
19ZNF217_24962896_ChIP-Seq_MCF-7_Human2.13359559
20HIF1A_21447827_ChIP-Seq_MCF-7_Human2.04327127
21EP300_21415370_ChIP-Seq_HL-1_Mouse2.04146610
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.01768431
23* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.98126358
24ESR1_15608294_ChIP-ChIP_MCF-7_Human1.95499707
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88678530
26SOX2_20726797_ChIP-Seq_SW620_Human1.82129840
27CJUN_26792858_Chip-Seq_BT549_Human1.81228475
28SCL_19346495_ChIP-Seq_HPC-7_Human1.79284308
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.78398316
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.76707529
31WT1_19549856_ChIP-ChIP_CCG9911_Human1.75709046
32EZH2_18974828_ChIP-Seq_MESCs_Mouse1.71493250
33RNF2_18974828_ChIP-Seq_MESCs_Mouse1.71493250
34SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.68801449
35EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.67701997
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.67668119
37JARID2_20075857_ChIP-Seq_MESCs_Mouse1.67107138
38ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.65181478
39GATA2_21666600_ChIP-Seq_HMVEC_Human1.61825401
40WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.61405891
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.58569360
42CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.58035043
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.53716781
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51983130
45FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.50858138
46AR_21572438_ChIP-Seq_LNCaP_Human1.48659175
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.48508977
48TP53_18474530_ChIP-ChIP_U2OS_Human1.48127845
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.45852078
50* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.45769937
51MTF2_20144788_ChIP-Seq_MESCs_Mouse1.45714678
52TP63_22573176_ChIP-Seq_HFKS_Human1.45346639
53KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.44322767
54KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.44322767
55KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.44322767
56* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.44306522
57* LXR_22292898_ChIP-Seq_THP-1_Human1.40948985
58CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.40860334
59TP53_20018659_ChIP-ChIP_R1E_Mouse1.40770101
60NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40090582
61SMC3_22415368_ChIP-Seq_MEFs_Mouse1.39896548
62UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.39755580
63RACK7_27058665_Chip-Seq_MCF-7_Human1.38710811
64ISL1_27105846_Chip-Seq_CPCs_Mouse1.37076951
65EZH2_27304074_Chip-Seq_ESCs_Mouse1.36183616
66ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35570766
67* TP53_22127205_ChIP-Seq_IMR90_Human1.35504090
68EZH2_27294783_Chip-Seq_ESCs_Mouse1.34077181
69PPAR_26484153_Chip-Seq_NCI-H1993_Human1.33068562
70ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.32763760
71NRF2_20460467_ChIP-Seq_MEFs_Mouse1.31375703
72NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.31375703
73SUZ12_27294783_Chip-Seq_ESCs_Mouse1.29718493
74* TP53_23651856_ChIP-Seq_MEFs_Mouse1.29543586
75BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.28374383
76AHR_22903824_ChIP-Seq_MCF-7_Human1.27567108
77BRD4_25478319_ChIP-Seq_HGPS_Human1.26078408
78RNF2_27304074_Chip-Seq_ESCs_Mouse1.25770240
79TBX20_22080862_ChIP-Seq_HEART_Mouse1.25542479
80TBX20_22328084_ChIP-Seq_HEART_Mouse1.25542479
81JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.23320995
82EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.21499832
83KDM2B_26808549_Chip-Seq_K562_Human1.21288194
84TP53_16413492_ChIP-PET_HCT116_Human1.18284057
85STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17840901
86SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17068508
87NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.16830328
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16801192
89SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.16019461
90SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.16019461
91OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.15999023
92TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15479398
93BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15333321
94WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14813717
95ESR1_20079471_ChIP-ChIP_T-47D_Human1.14165695
96RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.13955793
97* TET1_21490601_ChIP-Seq_MESCs_Mouse1.13822079
98THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13090889
99SALL4_18804426_ChIP-ChIP_XEN_Mouse1.12742490
100ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11565954
101TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10863912
102FOXO3_23340844_ChIP-Seq_DLD1_Human1.10671498
103DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10103913
104RING1B_27294783_Chip-Seq_ESCs_Mouse1.09748632
105ARNT_22903824_ChIP-Seq_MCF-7_Human1.08971089
106SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08337300
107* UBF1/2_26484160_Chip-Seq_HMECs_Human1.07735992
108BP1_19119308_ChIP-ChIP_Hs578T_Human1.07716754
109ATF3_27146783_Chip-Seq_COLON_Human1.06897367
110CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06645113
111ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.06354843
112CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03586096
113PIAS1_25552417_ChIP-Seq_VCAP_Human1.03084846
114SOX9_24532713_ChIP-Seq_HFSC_Mouse1.02125411
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.01716725
116KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01299478
117NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01223546
118GATA4_25053715_ChIP-Seq_YYC3_Human1.00854149
119ZNF263_19887448_ChIP-Seq_K562_Human0.97965570
120RING1B_27294783_Chip-Seq_NPCs_Mouse0.97478191
121ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97339275
122FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.96087054
123TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95573507
124VDR_24787735_ChIP-Seq_THP-1_Human0.95176722
125NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94909303
126RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.94061300
127NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92835731
128JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92702752
129GATA3_24758297_ChIP-Seq_MCF-7_Human0.91770624
130POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.90732412
131* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.90364536
132RXR_22158963_ChIP-Seq_LIVER_Mouse0.89128277
133NANOG_18692474_ChIP-Seq_MEFs_Mouse0.88121117
134FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.86224537
135PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.85427402
136JARID2_20064375_ChIP-Seq_MESCs_Mouse0.85153817
137RAD21_21589869_ChIP-Seq_MESCs_Mouse0.85015935
138CTCF_27219007_Chip-Seq_Bcells_Human0.84558019
139* TP63_23658742_ChIP-Seq_EP156T_Human0.83558346
140CTCF_27219007_Chip-Seq_ERYTHROID_Human0.82518576

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002876_abnormal_thyroid_physiology5.74303787
2MP0008438_abnormal_cutaneous_collagen4.75983893
3MP0005171_absent_coat_pigmentation4.56266427
4MP0005503_abnormal_tendon_morphology3.81864459
5MP0004272_abnormal_basement_membrane3.65709437
6MP0000013_abnormal_adipose_tissue3.35739842
7MP0005167_abnormal_blood-brain_barrier3.10498431
8MP0009780_abnormal_chondrocyte_physiolo2.97827959
9MP0003279_aneurysm2.93527587
10MP0006054_spinal_hemorrhage2.88868359
11MP0005275_abnormal_skin_tensile2.86475261
12MP0004782_abnormal_surfactant_physiolog2.67193704
13MP0005257_abnormal_intraocular_pressure2.43259401
14MP0003705_abnormal_hypodermis_morpholog2.35125557
15MP0002877_abnormal_melanocyte_morpholog2.32097467
16MP0005623_abnormal_meninges_morphology2.30474424
17MP0001879_abnormal_lymphatic_vessel2.30466791
18MP0000647_abnormal_sebaceous_gland2.29532335
19MP0000372_irregular_coat_pigmentation2.15677564
20MP0002796_impaired_skin_barrier2.12691000
21MP0000678_abnormal_parathyroid_gland2.05308300
22MP0004233_abnormal_muscle_weight1.97652176
23MP0003950_abnormal_plasma_membrane1.96097064
24MP0003183_abnormal_peptide_metabolism1.95139241
25MP0002127_abnormal_cardiovascular_syste1.94154632
26MP0005508_abnormal_skeleton_morphology1.93050646
27MP0003136_yellow_coat_color1.92836384
28MP0005409_darkened_coat_color1.92176273
29MP0010386_abnormal_urinary_bladder1.90851154
30MP0002295_abnormal_pulmonary_circulatio1.89246508
31MP0008004_abnormal_stomach_pH1.86274788
32MP0000750_abnormal_muscle_regeneration1.77684513
33* MP0000003_abnormal_adipose_tissue1.70180017
34MP0003941_abnormal_skin_development1.65323770
35MP0003045_fibrosis1.57413560
36MP0005408_hypopigmentation1.54957868
37MP0005367_renal/urinary_system_phenotyp1.54366249
38MP0000516_abnormal_urinary_system1.54366249
39MP0002160_abnormal_reproductive_system1.52992057
40MP0003828_pulmonary_edema1.49826190
41MP0003122_maternal_imprinting1.49621469
42MP0003942_abnormal_urinary_system1.48857855
43MP0010307_abnormal_tumor_latency1.48412568
44MP0002163_abnormal_gland_morphology1.43338526
45MP0002060_abnormal_skin_morphology1.41302744
46MP0003566_abnormal_cell_adhesion1.38313050
47MP0005220_abnormal_exocrine_pancreas1.36745572
48MP0009697_abnormal_copulation1.36465960
49MP0002837_dystrophic_cardiac_calcinosis1.34998667
50MP0002938_white_spotting1.33751719
51MP0010368_abnormal_lymphatic_system1.33614500
52MP0000534_abnormal_ureter_morphology1.30648812
53MP0003300_gastrointestinal_ulcer1.30233572
54MP0000377_abnormal_hair_follicle1.25776735
55MP0010234_abnormal_vibrissa_follicle1.25015913
56MP0001270_distended_abdomen1.23618143
57MP0002138_abnormal_hepatobiliary_system1.22741861
58MP0002751_abnormal_autonomic_nervous1.21282553
59MP0005076_abnormal_cell_differentiation1.21019553
60MP0000733_abnormal_muscle_development1.20551941
61MP0002108_abnormal_muscle_morphology1.19957498
62MP0003879_abnormal_hair_cell1.18682820
63MP0000163_abnormal_cartilage_morphology1.18614528
64MP0005248_abnormal_Harderian_gland1.17838802
65MP0005501_abnormal_skin_physiology1.17736278
66MP0005595_abnormal_vascular_smooth1.16404144
67MP0000383_abnormal_hair_follicle1.15180374
68MP0009250_abnormal_appendicular_skeleto1.14182812
69MP0005164_abnormal_response_to1.13860924
70MP0002168_other_aberrant_phenotype1.12395542
71MP0001756_abnormal_urination1.10802096
72MP0005379_endocrine/exocrine_gland_phen1.09573695
73MP0008775_abnormal_heart_ventricle1.09418816
74MP0004858_abnormal_nervous_system1.09181943
75* MP0001614_abnormal_blood_vessel1.08993771
76MP0002909_abnormal_adrenal_gland1.06904853
77MP0001944_abnormal_pancreas_morphology1.06859733
78MP0000462_abnormal_digestive_system1.06482071
79MP0003091_abnormal_cell_migration1.04755616
80* MP0005023_abnormal_wound_healing1.04576078
81MP0000681_abnormal_thyroid_gland1.04450923
82MP0002933_joint_inflammation1.03908156
83MP0004145_abnormal_muscle_electrophysio1.03691956
84MP0002896_abnormal_bone_mineralization1.03329240
85MP0005389_reproductive_system_phenotype1.03139782
86MP0005390_skeleton_phenotype1.02630396
87MP0000767_abnormal_smooth_muscle1.02305855
88MP0000427_abnormal_hair_cycle1.01733872
89MP0003195_calcinosis1.00762849
90MP0000467_abnormal_esophagus_morphology1.00541766
91MP0001849_ear_inflammation0.97476366
92MP0001216_abnormal_epidermal_layer0.97282997
93MP0009384_cardiac_valve_regurgitation0.96691343
94MP0003935_abnormal_craniofacial_develop0.96333606
95MP0003385_abnormal_body_wall0.95186091
96MP0010030_abnormal_orbit_morphology0.94916603
97MP0000343_altered_response_to0.92777115
98MP0001243_abnormal_dermal_layer0.90897492
99MP0004084_abnormal_cardiac_muscle0.90494167
100MP0005165_increased_susceptibility_to0.88878908
101MP0002972_abnormal_cardiac_muscle0.88657059
102MP0000613_abnormal_salivary_gland0.88380817
103MP0005645_abnormal_hypothalamus_physiol0.87401030
104MP0001542_abnormal_bone_strength0.87127002
105MP0000230_abnormal_systemic_arterial0.87106453
106MP0001915_intracranial_hemorrhage0.84298639
107MP0001661_extended_life_span0.84139564
108MP0003567_abnormal_fetal_cardiomyocyte0.83588375
109MP0005197_abnormal_uvea_morphology0.82943794
110MP0004885_abnormal_endolymph0.82159650
111MP0010678_abnormal_skin_adnexa0.81268114
112MP0004043_abnormal_pH_regulation0.81082792
113MP0003984_embryonic_growth_retardation0.80768327
114MP0002098_abnormal_vibrissa_morphology0.79035359
115MP0000858_altered_metastatic_potential0.78788733
116MP0000049_abnormal_middle_ear0.78715689
117MP0002128_abnormal_blood_circulation0.78653286
118MP0004085_abnormal_heartbeat0.78594871
119* MP0002086_abnormal_extraembryonic_tissu0.78569126
120MP0002088_abnormal_embryonic_growth/wei0.78443797
121MP0010771_integument_phenotype0.78287848
122MP0000428_abnormal_craniofacial_morphol0.77666227
123MP0000762_abnormal_tongue_morphology0.77299546
124MP0001958_emphysema0.77233571
125MP0002932_abnormal_joint_morphology0.76421720
126MP0006138_congestive_heart_failure0.76197001
127MP0002693_abnormal_pancreas_physiology0.75895839
128MP0001175_abnormal_lung_morphology0.75781104
129MP0001881_abnormal_mammary_gland0.74978056
130MP0000465_gastrointestinal_hemorrhage0.74229545
131MP0003115_abnormal_respiratory_system0.72825382
132MP0001177_atelectasis0.72637120
133MP0002697_abnormal_eye_size0.71730492
134* MP0002925_abnormal_cardiovascular_devel0.71420862
135MP0000266_abnormal_heart_morphology0.70695002
136MP0009840_abnormal_foam_cell0.68392869
137MP0005369_muscle_phenotype0.68340225
138MP0004883_abnormal_blood_vessel0.68011905
139MP0002115_abnormal_skeleton_extremities0.67070431
140MP0003936_abnormal_reproductive_system0.66723196
141MP0005380_embryogenesis_phenotype0.66600657
142MP0001672_abnormal_embryogenesis/_devel0.66600657
143MP0002113_abnormal_skeleton_development0.66185903
144MP0009278_abnormal_bone_marrow0.65536504
145MP0000358_abnormal_cell_content/0.65157096
146MP0003453_abnormal_keratinocyte_physiol0.64962106
147MP0004264_abnormal_extraembryonic_tissu0.64383293
148MP0001784_abnormal_fluid_regulation0.64077328
149* MP0005375_adipose_tissue_phenotype0.62008976
150MP0003303_peritoneal_inflammation0.60046911
151MP0000631_abnormal_neuroendocrine_gland0.59489694
152MP0000627_abnormal_mammary_gland0.57872472
153MP0000367_abnormal_coat/_hair0.55844735
154MP0005670_abnormal_white_adipose0.54503497

Predicted human phenotypes

RankGene SetZ-score
1Wrist flexion contracture (HP:0001239)7.21128956
2Hypokalemic alkalosis (HP:0001949)5.29934486
3Nonimmune hydrops fetalis (HP:0001790)4.44251218
4Decreased circulating renin level (HP:0003351)4.33108672
5Hyperactive renin-angiotensin system (HP:0000841)4.23574356
6Esophageal varix (HP:0002040)4.05959561
7Fragile nails (HP:0001808)4.03111741
8Hyperaldosteronism (HP:0000859)3.91298766
9Premature rupture of membranes (HP:0001788)3.79863745
10Vertebral compression fractures (HP:0002953)3.77956059
11Arterial tortuosity (HP:0005116)3.76284248
12Vascular tortuosity (HP:0004948)3.70181582
13Hematochezia (HP:0002573)3.67500876
14Renal salt wasting (HP:0000127)3.56956478
15Hip contracture (HP:0003273)3.56516193
16Chronic bronchitis (HP:0004469)3.56223850
17Woolly hair (HP:0002224)3.55442749
18Amelogenesis imperfecta (HP:0000705)3.50107907
19Cervical subluxation (HP:0003308)3.46893477
20Abnormality of the right ventricle (HP:0001707)3.43641832
21Aplasia cutis congenita (HP:0001057)3.42319988
22Natal tooth (HP:0000695)3.41210450
23Delayed closure of the anterior fontanelle (HP:0001476)3.39677653
24Abnormality of chloride homeostasis (HP:0011422)3.33906944
25Protrusio acetabuli (HP:0003179)3.27068212
26Absent hand (HP:0004050)3.20743102
27Hypokalemia (HP:0002900)3.12068385
28Hypothermia (HP:0002045)3.07737106
29Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.07080904
30Skull defect (HP:0001362)3.03877298
31Hyperkalemia (HP:0002153)3.00486497
32Asymmetry of the thorax (HP:0001555)2.99610982
33Abnormality of cochlea (HP:0000375)2.97674476
34Spontaneous hematomas (HP:0007420)2.97533578
35Neonatal death (HP:0003811)2.90785715
36Chondrocalcinosis (HP:0000934)2.90659422
37Adrenal overactivity (HP:0002717)2.86847252
38Polycythemia (HP:0001901)2.85983948
39Hypochromic microcytic anemia (HP:0004840)2.85774639
40Atrophic scars (HP:0001075)2.84786113
41Fibular aplasia (HP:0002990)2.83425123
42Limited hip movement (HP:0008800)2.79365650
43Abnormality of Sharpey fibers (HP:0100685)2.75279272
44Soft skin (HP:0000977)2.73410066
45Bladder diverticulum (HP:0000015)2.64600616
46Right ventricular cardiomyopathy (HP:0011663)2.63964136
47Short clavicles (HP:0000894)2.62116560
48Ankle contracture (HP:0006466)2.60937932
49Bulbous nose (HP:0000414)2.59907301
50Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.57897284
51Hyponatremia (HP:0002902)2.57218874
52Aplasia/Hypoplasia of the clavicles (HP:0006710)2.57130942
53Broad metatarsal (HP:0001783)2.56787992
54Abnormality of dentin (HP:0010299)2.54411686
55White forelock (HP:0002211)2.52054357
56Aortic dissection (HP:0002647)2.49965135
57Adactyly (HP:0009776)2.47588416
58Delayed cranial suture closure (HP:0000270)2.43620873
59Trismus (HP:0000211)2.40681919
60Shallow orbits (HP:0000586)2.38864060
61Hyperparathyroidism (HP:0000843)2.37124367
62Cerebral aneurysm (HP:0004944)2.36898186
63Abnormality of the acetabulum (HP:0003170)2.36540637
64Capillary hemangiomas (HP:0005306)2.34922643
65Cerebral hemorrhage (HP:0001342)2.33954706
66Abnormality of sodium homeostasis (HP:0010931)2.33288246
67Morphological abnormality of the inner ear (HP:0011390)2.31127971
68Conjunctival telangiectasia (HP:0000524)2.30668268
69Aneurysm (HP:0002617)2.28256232
70Aortic aneurysm (HP:0004942)2.27759666
71Broad ribs (HP:0000885)2.23434532
72Absent eyelashes (HP:0000561)2.21959251
73Abnormality of potassium homeostasis (HP:0011042)2.21873422
74Abnormality of dental color (HP:0011073)2.21429834
75Spinal rigidity (HP:0003306)2.20103696
76Portal hypertension (HP:0001409)2.19797016
77Abnormality of calcium-phosphate metabolism (HP:0100530)2.18710933
78Joint contractures involving the joints of the feet (HP:0100492)2.16587756
79Flexion contracture of toe (HP:0005830)2.16587756
80Osteomalacia (HP:0002749)2.15723873
81Aplasia of the musculature (HP:0100854)2.15252542
82Broad face (HP:0000283)2.14439378
83Hyperinsulinemic hypoglycemia (HP:0000825)2.14128607
84Alkalosis (HP:0001948)2.13676448
85Abnormality of endocrine pancreas physiology (HP:0012093)2.12948094
86Abnormality of the pancreatic islet cells (HP:0006476)2.12948094
87Abnormality of molar morphology (HP:0011070)2.12533807
88Abnormality of molar (HP:0011077)2.12533807
89Rectal prolapse (HP:0002035)2.11571868
90Onycholysis (HP:0001806)2.10514586
91Narrow nasal bridge (HP:0000446)2.10259401
92Abnormality of the frontal sinuses (HP:0002687)2.09616874
93Bilateral sensorineural hearing impairment (HP:0008619)2.08854583
94Exostoses (HP:0100777)2.06465797
95Hypoglycemic seizures (HP:0002173)2.06452710
96Spinal muscular atrophy (HP:0007269)2.06303167
97Abnormality of permanent molar morphology (HP:0011071)2.06052565
98Abnormality of the dental root (HP:0006486)2.06052565
99Taurodontia (HP:0000679)2.06052565
100Bone cyst (HP:0012062)2.05734646
101Bell-shaped thorax (HP:0001591)2.04182876
102Conjugated hyperbilirubinemia (HP:0002908)2.02067534
103Hyperextensible skin (HP:0000974)2.01821226
104Absent eyebrow (HP:0002223)2.01704803
105Metabolic alkalosis (HP:0200114)2.00359024
106Wormian bones (HP:0002645)1.99663019
107Patchy hypopigmentation of hair (HP:0011365)1.99650727
108Bilateral microphthalmos (HP:0007633)1.99578222
109Skin nodule (HP:0200036)1.98349157
110Tarsal synostosis (HP:0008368)1.97830344
111Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.96146124
112Abnormality of the hepatic vasculature (HP:0006707)1.95921190
113Nuclear cataract (HP:0100018)1.94371288
114Symptomatic seizures (HP:0011145)1.92801925
115Advanced eruption of teeth (HP:0006288)1.92724277
116Ileus (HP:0002595)1.92182531
117Renal tubular acidosis (HP:0001947)1.92172307
118Ketoacidosis (HP:0001993)1.91716656
119Bifid uvula (HP:0000193)1.91229622
120Exocrine pancreatic insufficiency (HP:0001738)1.89910134
121Tinnitus (HP:0000360)1.88965682
122Small epiphyses (HP:0010585)1.88348244
123Visceral angiomatosis (HP:0100761)1.88286099
124Enlarged penis (HP:0000040)1.85904949
125Venous insufficiency (HP:0005293)1.85709133
126Blue sclerae (HP:0000592)1.85045884
127Abnormality of the dental pulp (HP:0006479)1.84330285
128Lymphangioma (HP:0100764)1.83733301
129Hypercortisolism (HP:0001578)1.82395737
130Short nail (HP:0001799)1.82393439
131Distal lower limb muscle weakness (HP:0009053)1.82138032
132Large for gestational age (HP:0001520)1.81318397
133Synostosis involving bones of the lower limbs (HP:0009138)1.81101147
134Synostosis involving bones of the feet (HP:0009140)1.81101147
135Aortic valve stenosis (HP:0001650)1.81032938
136Subacute progressive viral hepatitis (HP:0006572)1.80398248
137Short hallux (HP:0010109)1.80249422
138Fragile skin (HP:0001030)1.79550847
139Increased connective tissue (HP:0009025)1.79149394
140Venous abnormality (HP:0002624)1.78968906
141Abnormality of renin-angiotensin system (HP:0000847)1.78579491
142Difficulty climbing stairs (HP:0003551)1.78350658
143Popliteal pterygium (HP:0009756)1.78315840
144Abnormality of the parietal bone (HP:0002696)1.77412159
145Hypotension (HP:0002615)1.76125358
146Malignant hyperthermia (HP:0002047)1.76083887
147Hydroureter (HP:0000072)1.76081245
148Hyperglycemia (HP:0003074)1.75833880
149Hemangiomatosis (HP:0007461)1.74772561
150Dilatation of the ascending aorta (HP:0005111)1.74450808
151Disproportionate short-trunk short stature (HP:0003521)1.73654977
152Palmoplantar hyperkeratosis (HP:0000972)1.72850560
153Increased variability in muscle fiber diameter (HP:0003557)1.72719154
154Joint laxity (HP:0001388)1.72319295
155Split hand (HP:0001171)1.71335126
156Hyporeflexia of lower limbs (HP:0002600)1.71192180
157Anterior segment dysgenesis (HP:0007700)1.71168478
158Abnormality of nail color (HP:0100643)1.71038935
159Milia (HP:0001056)1.70861107
160Fused cervical vertebrae (HP:0002949)1.70722230
161Congenital ichthyosiform erythroderma (HP:0007431)1.70664438
162Heterochromia iridis (HP:0001100)1.69740564
163Follicular hyperkeratosis (HP:0007502)1.67518676
164Platyspondyly (HP:0000926)1.67171274
165Vertebral clefting (HP:0008428)1.65862287
166Cardiovascular calcification (HP:0011915)1.65250214
167Plantar hyperkeratosis (HP:0007556)1.64625363
168Neonatal short-limb short stature (HP:0008921)1.64222672
169Protuberant abdomen (HP:0001538)1.63751911
170Abnormality of the nasal mucosa (HP:0000433)1.63670500
171Abnormal vertebral ossification (HP:0100569)1.62193036
172Pterygium (HP:0001059)1.61615365
173Micronodular cirrhosis (HP:0001413)1.61439379
174Congenital glaucoma (HP:0001087)1.61025832
175Mesomelia (HP:0003027)1.60382469

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK24.49904954
2FRK4.04062108
3PRKD33.70532727
4EPHA33.68322019
5MAPK152.83797588
6PDGFRA2.80794752
7INSRR2.52559375
8EPHA22.46528505
9MYLK2.40007963
10ICK2.29122435
11ERN12.21323240
12FER2.13606481
13PIM21.99966784
14MAP3K21.98842235
15TYRO31.92341209
16NME11.91701261
17MAP3K31.84814017
18TTN1.81610207
19PIK3CG1.79523850
20WNK41.67049115
21ERBB31.59766557
22STK38L1.58776165
23PTK61.58285617
24MET1.55915836
25SMG11.52832463
26BMX1.51505640
27PTK21.45101594
28MATK1.44669431
29PRKG21.33061252
30DDR21.32916235
31PTK2B1.31029387
32PASK1.30922945
33PAK21.28154509
34FES1.28098389
35MOS1.27823966
36TESK11.25578189
37EPHB11.24322717
38HIPK21.23286363
39RIPK11.18744166
40TRIB31.18480350
41CDC42BPA1.17444993
42WNK31.15180827
43MAP3K71.14215417
44PAK31.11931737
45MAP2K21.11263965
46ROCK11.10434048
47ILK1.07713320
48STK241.06240914
49TIE11.06110422
50DYRK1B1.03221386
51NTRK11.01676305
52GRK11.00427821
53RPS6KA40.99005308
54EPHB20.98614622
55MAP2K10.97837899
56PRKCH0.96215220
57PRKCE0.91765075
58TGFBR10.88070434
59BMPR1B0.85680273
60ERBB40.80650223
61FLT30.79610653
62PRPF4B0.78701299
63MAPKAPK30.78524052
64PDGFRB0.77668744
65BRAF0.76675765
66CAMKK20.75992546
67LATS10.75027076
68MAP3K10.73806764
69SCYL20.73313659
70PRKAA20.71938915
71DAPK30.71427693
72BMPR20.69000075
73PKN10.68762687
74ADRBK10.66368179
75PDK20.63310980
76KIT0.62962566
77NUAK10.62729217
78RET0.62582962
79ARAF0.61751287
80DMPK0.61345410
81TBK10.61099914
82AKT30.60458392
83TRPM70.60375514
84AKT20.60290023
85FGFR30.60191659
86NME20.58539802
87RPS6KA20.57827960
88UHMK10.57010279
89ZAK0.56934364
90ABL20.55874769
91PRKD20.55578103
92CAMK2D0.53816143
93LIMK10.53160063
94TAOK20.51378770
95PBK0.51212096
96LRRK20.51106724
97EIF2AK30.50574436
98SIK10.50555898
99PAK40.49668976
100PKN20.49350279
101RPS6KA60.49238611
102TGFBR20.48830365
103IRAK30.46825695
104PIK3CA0.46803740
105MUSK0.45893778
106PRKD10.45680326
107KDR0.44906684
108ROCK20.44678988
109NEK10.44662348
110SRC0.43100153
111TAF10.42952144
112STK390.42917251
113TESK20.41583070
114WNK10.41482912
115MAPK70.41019617
116PLK20.39957286
117RPS6KL10.39861808
118RPS6KC10.39861808
119MELK0.39414849
120PRKAA10.38900479
121LATS20.38744837
122PDPK10.38337439
123CDK90.38062605
124CHUK0.37739701
125STK100.36843220
126GRK50.35991082
127INSR0.35738628
128GSK3A0.35627257
129WEE10.35533421
130MAPK120.34673479
131STK380.33844232
132IRAK10.32541679
133PIM10.32314745
134CAMK40.32111423
135MAPKAPK20.31846436
136NEK90.31825601
137VRK20.30790680
138DAPK10.29976857
139RPS6KB20.29969562
140FGFR10.29874234
141CDK80.29627056
142PRKCI0.29243309
143MAPKAPK50.28817362
144MTOR0.28033580
145MARK20.24800743
146CDK70.24790766
147MAP3K80.23963640
148EEF2K0.23962835
149CSK0.23462322

Predicted pathways (KEGG)

RankGene SetZ-score
1Ovarian steroidogenesis_Homo sapiens_hsa049134.60104454
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.72681921
3Protein export_Homo sapiens_hsa030603.26688183
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.95465110
5p53 signaling pathway_Homo sapiens_hsa041152.76639841
6Vibrio cholerae infection_Homo sapiens_hsa051102.30713389
7ECM-receptor interaction_Homo sapiens_hsa045122.28552788
8* Focal adhesion_Homo sapiens_hsa045102.10341395
9Insulin secretion_Homo sapiens_hsa049111.91059166
10Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.84168159
11Bladder cancer_Homo sapiens_hsa052191.72410926
12Cyanoamino acid metabolism_Homo sapiens_hsa004601.71649395
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.69856489
14GnRH signaling pathway_Homo sapiens_hsa049121.65870500
15Adherens junction_Homo sapiens_hsa045201.62711407
16Protein digestion and absorption_Homo sapiens_hsa049741.60152140
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.58311039
18Arginine and proline metabolism_Homo sapiens_hsa003301.54492894
19Sulfur relay system_Homo sapiens_hsa041221.53505629
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.53179223
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.50014378
22Amoebiasis_Homo sapiens_hsa051461.49771082
23Dilated cardiomyopathy_Homo sapiens_hsa054141.49000540
24Proteoglycans in cancer_Homo sapiens_hsa052051.48356936
25Prostate cancer_Homo sapiens_hsa052151.40970688
26Malaria_Homo sapiens_hsa051441.36891837
27Vascular smooth muscle contraction_Homo sapiens_hsa042701.30663573
28Sulfur metabolism_Homo sapiens_hsa009201.27290907
29Sphingolipid metabolism_Homo sapiens_hsa006001.22655930
30Arginine biosynthesis_Homo sapiens_hsa002201.22202285
31Rheumatoid arthritis_Homo sapiens_hsa053231.21328495
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.19676607
33Thyroid hormone synthesis_Homo sapiens_hsa049181.18534128
34Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.18476306
35Small cell lung cancer_Homo sapiens_hsa052221.17576541
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16378364
37Pancreatic secretion_Homo sapiens_hsa049721.16254402
38Autoimmune thyroid disease_Homo sapiens_hsa053201.14842864
39Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.14329129
40Taste transduction_Homo sapiens_hsa047421.12837573
41Collecting duct acid secretion_Homo sapiens_hsa049661.12470704
42Notch signaling pathway_Homo sapiens_hsa043301.11053729
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10690419
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09719964
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.09087345
46Renin secretion_Homo sapiens_hsa049241.08197940
47Hippo signaling pathway_Homo sapiens_hsa043901.06306530
48Melanoma_Homo sapiens_hsa052181.04490484
49* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.04025579
50Glycosaminoglycan degradation_Homo sapiens_hsa005311.03469628
51Tight junction_Homo sapiens_hsa045301.00972310
52Endometrial cancer_Homo sapiens_hsa052130.99657723
53Melanogenesis_Homo sapiens_hsa049160.98691900
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98196851
55MicroRNAs in cancer_Homo sapiens_hsa052060.95129031
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.94540489
57Legionellosis_Homo sapiens_hsa051340.93540985
58Estrogen signaling pathway_Homo sapiens_hsa049150.93208280
59TGF-beta signaling pathway_Homo sapiens_hsa043500.93152543
60Gap junction_Homo sapiens_hsa045400.92114478
61Insulin resistance_Homo sapiens_hsa049310.91036869
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90068822
63Cholinergic synapse_Homo sapiens_hsa047250.89337938
64Phagosome_Homo sapiens_hsa041450.89269234
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89064735
66Toxoplasmosis_Homo sapiens_hsa051450.88408922
67* Pathways in cancer_Homo sapiens_hsa052000.88200605
68Galactose metabolism_Homo sapiens_hsa000520.86795688
69Glioma_Homo sapiens_hsa052140.86269055
70TNF signaling pathway_Homo sapiens_hsa046680.85320052
71Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84821928
72Basal cell carcinoma_Homo sapiens_hsa052170.83048117
73Prion diseases_Homo sapiens_hsa050200.80307938
74Dorso-ventral axis formation_Homo sapiens_hsa043200.79708013
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79372924
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79210772
77Cocaine addiction_Homo sapiens_hsa050300.79026322
78Lysosome_Homo sapiens_hsa041420.78460299
79Vitamin digestion and absorption_Homo sapiens_hsa049770.77181178
80HIF-1 signaling pathway_Homo sapiens_hsa040660.76533089
81Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76150359
82Pancreatic cancer_Homo sapiens_hsa052120.76122629
83Circadian entrainment_Homo sapiens_hsa047130.75721412
84Hedgehog signaling pathway_Homo sapiens_hsa043400.75629397
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74624480
86Chronic myeloid leukemia_Homo sapiens_hsa052200.71786062
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71567691
88Prolactin signaling pathway_Homo sapiens_hsa049170.71092573
89Axon guidance_Homo sapiens_hsa043600.69945061
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69908367
91Central carbon metabolism in cancer_Homo sapiens_hsa052300.69443145
92Type I diabetes mellitus_Homo sapiens_hsa049400.69320952
93Renal cell carcinoma_Homo sapiens_hsa052110.69182852
94Type II diabetes mellitus_Homo sapiens_hsa049300.68651293
95* Rap1 signaling pathway_Homo sapiens_hsa040150.66883207
96Gastric acid secretion_Homo sapiens_hsa049710.66046950
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65538935
98Glucagon signaling pathway_Homo sapiens_hsa049220.63611692
99Salivary secretion_Homo sapiens_hsa049700.63318090
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62222812
101Complement and coagulation cascades_Homo sapiens_hsa046100.61508443
102Platelet activation_Homo sapiens_hsa046110.61080156
103Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.59252252
104N-Glycan biosynthesis_Homo sapiens_hsa005100.58163023
105Ether lipid metabolism_Homo sapiens_hsa005650.57482743
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57339864
107ABC transporters_Homo sapiens_hsa020100.56280782
108Thyroid cancer_Homo sapiens_hsa052160.55899921
109Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55844619
110Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55787988
111Selenocompound metabolism_Homo sapiens_hsa004500.54717749
112Endocytosis_Homo sapiens_hsa041440.54462916
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.52546613
114HTLV-I infection_Homo sapiens_hsa051660.52280865
115cAMP signaling pathway_Homo sapiens_hsa040240.51876385
116Oxytocin signaling pathway_Homo sapiens_hsa049210.51759214
117ErbB signaling pathway_Homo sapiens_hsa040120.50810119
118Circadian rhythm_Homo sapiens_hsa047100.49954179
119* Ras signaling pathway_Homo sapiens_hsa040140.49392719
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.49170883
121Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47547552
122Mineral absorption_Homo sapiens_hsa049780.47453718
123Apoptosis_Homo sapiens_hsa042100.47445341
124Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46979756
125Amphetamine addiction_Homo sapiens_hsa050310.45730589
126Inositol phosphate metabolism_Homo sapiens_hsa005620.44354551
127Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43823964
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43775190
129Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43692163
130Glutathione metabolism_Homo sapiens_hsa004800.42240074
131Wnt signaling pathway_Homo sapiens_hsa043100.41362886
132Fructose and mannose metabolism_Homo sapiens_hsa000510.41331858
133PPAR signaling pathway_Homo sapiens_hsa033200.39275930
134VEGF signaling pathway_Homo sapiens_hsa043700.38781430
135Phospholipase D signaling pathway_Homo sapiens_hsa040720.30083654
136Fat digestion and absorption_Homo sapiens_hsa049750.29795385
137Cell cycle_Homo sapiens_hsa041100.28253984
138Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.25355338
139Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.22443452
140Metabolic pathways_Homo sapiens_hsa011000.21349345

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