PGGT1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Protein geranylgeranyltransferase type I (GGTase-I) transfers a geranylgeranyl group to the cysteine residue of candidate proteins containing a C-terminal CAAX motif in which 'A' is an aliphatic amino acid and 'X' is leucine (summarized by Zhang et al., 1994 [PubMed 8106351]). The enzyme is composed of a 48-kD alpha subunit (FNTA; MIM 134635) and a 43-kD beta subunit, encoded by the PGGT1B gene. The FNTA gene encodes the alpha subunit for both GGTase-I and the related enzyme farnesyltransferase. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)4.80719893
2positive regulation of mitotic sister chromatid separation (GO:1901970)4.61763781
3positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.61763781
4positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.61763781
5fucose catabolic process (GO:0019317)4.52387593
6L-fucose metabolic process (GO:0042354)4.52387593
7L-fucose catabolic process (GO:0042355)4.52387593
8* protein prenylation (GO:0018342)4.46654727
9* prenylation (GO:0097354)4.46654727
10DNA unwinding involved in DNA replication (GO:0006268)4.38043365
11energy homeostasis (GO:0097009)4.14554595
12respiratory chain complex IV assembly (GO:0008535)3.94408215
13DNA double-strand break processing (GO:0000729)3.88078812
14regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.87004446
15regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.86129750
16cellular response to exogenous dsRNA (GO:0071360)3.75539968
17DNA strand elongation involved in DNA replication (GO:0006271)3.70274143
18DNA deamination (GO:0045006)3.59279894
19cytochrome complex assembly (GO:0017004)3.57528405
20artery smooth muscle contraction (GO:0014824)3.55050849
21negative regulation of DNA-dependent DNA replication (GO:2000104)3.54166875
22DNA strand elongation (GO:0022616)3.50937307
23telomere maintenance via semi-conservative replication (GO:0032201)3.50437144
24water-soluble vitamin biosynthetic process (GO:0042364)3.49710103
25positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.47948922
26non-recombinational repair (GO:0000726)3.33082657
27double-strand break repair via nonhomologous end joining (GO:0006303)3.33082657
28S-adenosylmethionine metabolic process (GO:0046500)3.29080740
29telomere maintenance via recombination (GO:0000722)3.28065063
30regulation of interleukin-12 biosynthetic process (GO:0045075)3.27877186
31mitotic recombination (GO:0006312)3.26886790
32synapsis (GO:0007129)3.22567299
33keratinocyte development (GO:0003334)3.21979956
34regulation of meiosis I (GO:0060631)3.16252883
35RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.16059809
36DNA replication initiation (GO:0006270)3.15884442
37cellular ketone body metabolic process (GO:0046950)3.15832204
38tonic smooth muscle contraction (GO:0014820)3.15479399
39purine nucleobase biosynthetic process (GO:0009113)3.14327162
40regulation of nuclear cell cycle DNA replication (GO:0033262)3.10017694
41kidney morphogenesis (GO:0060993)3.07161331
42IMP biosynthetic process (GO:0006188)3.06951292
43epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.04262735
44negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.03208766
45negative regulation of translation, ncRNA-mediated (GO:0040033)3.03208766
46regulation of translation, ncRNA-mediated (GO:0045974)3.03208766
47resolution of meiotic recombination intermediates (GO:0000712)3.01333401
48CENP-A containing nucleosome assembly (GO:0034080)3.00023036
49IMP metabolic process (GO:0046040)2.99743688
50nucleobase biosynthetic process (GO:0046112)2.98754831
51recombinational repair (GO:0000725)2.98018708
52replication fork processing (GO:0031297)2.97854277
53cellular response to interferon-beta (GO:0035458)2.96181924
54polyol catabolic process (GO:0046174)2.96086091
55inositol phosphate catabolic process (GO:0071545)2.95583718
56negative regulation of activin receptor signaling pathway (GO:0032926)2.94519783
57intraciliary transport (GO:0042073)2.93975350
58double-strand break repair via homologous recombination (GO:0000724)2.93538840
59preassembly of GPI anchor in ER membrane (GO:0016254)2.93292350
60translesion synthesis (GO:0019985)2.93260897
61neural tube formation (GO:0001841)2.92603971
62mitotic nuclear envelope disassembly (GO:0007077)2.92265425
63antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.91347403
64antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.91347403
65endothelium development (GO:0003158)2.91304080
66regulation of DNA endoreduplication (GO:0032875)2.90392968
67ketone body metabolic process (GO:1902224)2.90064809
68regulation of sister chromatid cohesion (GO:0007063)2.88841693
69photoreceptor cell maintenance (GO:0045494)2.88433852
70nucleotide-excision repair, DNA gap filling (GO:0006297)2.87227589
71response to nitrosative stress (GO:0051409)2.86301104
72regulation of glucokinase activity (GO:0033131)2.85721021
73regulation of hexokinase activity (GO:1903299)2.85721021
74acrosome assembly (GO:0001675)2.85381347
75regulation of spindle organization (GO:0090224)2.84079590
76chromatin remodeling at centromere (GO:0031055)2.83840125
77protein localization to kinetochore (GO:0034501)2.82931379
78DNA replication checkpoint (GO:0000076)2.81465925
79protein K11-linked deubiquitination (GO:0035871)2.80447468
80telomere maintenance via telomere lengthening (GO:0010833)2.80367326
81L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.79847218
82antigen processing and presentation of endogenous antigen (GO:0019883)2.79417642
83Golgi transport vesicle coating (GO:0048200)2.77836226
84COPI coating of Golgi vesicle (GO:0048205)2.77836226
85protein K6-linked ubiquitination (GO:0085020)2.76305018
86histone mRNA catabolic process (GO:0071044)2.74698330
87lactate metabolic process (GO:0006089)2.74513826
88exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.74112707
89adenosine metabolic process (GO:0046085)2.73124454
90indolalkylamine metabolic process (GO:0006586)2.72257435
91nuclear pore complex assembly (GO:0051292)2.70804950
92positive regulation of histone H3-K4 methylation (GO:0051571)2.70650724
93histone H2A acetylation (GO:0043968)2.69991437
94detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.69830288
95nuclear envelope disassembly (GO:0051081)2.68664475
96membrane disassembly (GO:0030397)2.68664475
97phosphorylated carbohydrate dephosphorylation (GO:0046838)2.67288229
98inositol phosphate dephosphorylation (GO:0046855)2.67288229
99somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.66351396
100isotype switching (GO:0045190)2.66351396
101somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.66351396
102platelet dense granule organization (GO:0060155)2.65434538
103methionine biosynthetic process (GO:0009086)2.65357135
104nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.65193395
105cellular response to dsRNA (GO:0071359)2.64945735
106nuclear pore organization (GO:0006999)2.63658931
107regulation of translation in response to stress (GO:0043555)2.63460272
108positive regulation of protein import into nucleus, translocation (GO:0033160)2.63423921
109positive regulation of protein autophosphorylation (GO:0031954)2.63234654
110purine ribonucleotide transport (GO:0015868)2.63173890
111vesicle fusion (GO:0006906)2.63122953
112DNA geometric change (GO:0032392)2.63016427
113DNA strand renaturation (GO:0000733)2.62838642
114cellular response to zinc ion (GO:0071294)2.61899608
115DNA duplex unwinding (GO:0032508)2.61078606
116DNA demethylation (GO:0080111)2.61039653
117neurotransmitter catabolic process (GO:0042135)2.60791623
118regulation of interferon-beta biosynthetic process (GO:0045357)2.60439023
119skeletal muscle tissue regeneration (GO:0043403)2.59901738
120antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.58206345
121positive regulation of glycolytic process (GO:0045821)2.57346554
122branched-chain amino acid catabolic process (GO:0009083)2.54450492
123kynurenine metabolic process (GO:0070189)2.54199182
124ribonucleoprotein complex disassembly (GO:0032988)2.54092682
125prostate gland growth (GO:0060736)2.53212160
126indole-containing compound catabolic process (GO:0042436)2.53040826
127indolalkylamine catabolic process (GO:0046218)2.53040826
128tryptophan catabolic process (GO:0006569)2.53040826
129tachykinin receptor signaling pathway (GO:0007217)2.52597300
130telomere maintenance (GO:0000723)2.52548160
131negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.52241716
132telomere organization (GO:0032200)2.51762156
133folic acid-containing compound biosynthetic process (GO:0009396)2.51462866
134response to muramyl dipeptide (GO:0032495)2.51422460
135negative regulation of DNA recombination (GO:0045910)2.51405374
136positive regulation of gamma-delta T cell activation (GO:0046645)2.50976238
137regulation of sarcomere organization (GO:0060297)2.50740516
138L-methionine salvage (GO:0071267)2.50655017
139L-methionine biosynthetic process (GO:0071265)2.50655017
140amino acid salvage (GO:0043102)2.50655017
141positive regulation of interferon-alpha production (GO:0032727)2.49434280
142regulation of helicase activity (GO:0051095)2.49107375
143hepatocyte apoptotic process (GO:0097284)2.47696198
144regulation of action potential (GO:0098900)2.47256569
145regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.46340836
146regulation of mitotic spindle checkpoint (GO:1903504)2.46340836
147positive regulation by symbiont of host defense response (GO:0052509)2.46191437
148modulation by symbiont of host defense response (GO:0052031)2.46191437
149modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.46191437
150modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.46191437
151positive regulation by organism of defense response of other organism involved in symbiotic interact2.46191437
152modulation by symbiont of host immune response (GO:0052553)2.46191437
153rRNA modification (GO:0000154)2.45639777
154negative regulation of phagocytosis (GO:0050765)2.45120899
155protein complex biogenesis (GO:0070271)2.45081280
156positive regulation of B cell differentiation (GO:0045579)2.44647610
157early endosome to late endosome transport (GO:0045022)2.44621539
158DNA replication-independent nucleosome organization (GO:0034724)2.43649831
159DNA replication-independent nucleosome assembly (GO:0006336)2.43649831
160response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.43081243
161response to host immune response (GO:0052572)2.43081243
162epithelial cilium movement (GO:0003351)2.42877265
163neutrophil mediated immunity (GO:0002446)2.42143713
164tryptophan metabolic process (GO:0006568)2.41302374
165proteasome assembly (GO:0043248)2.40684087
166postreplication repair (GO:0006301)2.39658271
167macrophage activation (GO:0042116)2.37984873
168production of molecular mediator involved in inflammatory response (GO:0002532)2.37511215
169organelle disassembly (GO:1903008)2.37092379
170establishment of protein localization to Golgi (GO:0072600)2.36886817
171DNA damage induced protein phosphorylation (GO:0006975)2.36690317
172regulation of interferon-alpha production (GO:0032647)2.33537310
173monoubiquitinated protein deubiquitination (GO:0035520)2.32716917
174signal peptide processing (GO:0006465)2.32237105
175regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.31615388
176gap junction assembly (GO:0016264)2.31509087
177mRNA cleavage (GO:0006379)2.31440038
178positive regulation of interferon-beta production (GO:0032728)2.30236683
179response to interferon-beta (GO:0035456)2.29241512
180kinetochore organization (GO:0051383)2.28634867
181DNA topological change (GO:0006265)2.28552441
182attachment of spindle microtubules to kinetochore (GO:0008608)2.28197851
183ribosomal small subunit assembly (GO:0000028)2.23814511
184protein localization to chromosome, centromeric region (GO:0071459)2.23685926
185transcription-coupled nucleotide-excision repair (GO:0006283)2.23611697
186prostaglandin biosynthetic process (GO:0001516)2.22606137
187prostanoid biosynthetic process (GO:0046457)2.22606137
188disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.22249253
189killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.22249253
190histone exchange (GO:0043486)2.21874459
191mitotic sister chromatid cohesion (GO:0007064)2.20307441
192sequestering of metal ion (GO:0051238)2.18288082
193response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.17774470
194response to host (GO:0075136)2.17774470
195response to host defenses (GO:0052200)2.17774470
196regulation of MHC class II biosynthetic process (GO:0045346)2.16281083

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.85288990
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.57247285
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.49237939
4* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.29152411
5ZNF274_21170338_ChIP-Seq_K562_Hela3.06154602
6VDR_22108803_ChIP-Seq_LS180_Human3.03864548
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.95225288
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.93460302
9GBX2_23144817_ChIP-Seq_PC3_Human2.68794688
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.67667233
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.66976348
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.64823134
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.62775966
14TAF15_26573619_Chip-Seq_HEK293_Human2.58241968
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.56824546
16FUS_26573619_Chip-Seq_HEK293_Human2.42937286
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.36724148
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32395734
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.31017084
20P300_19829295_ChIP-Seq_ESCs_Human2.28832608
21IGF1R_20145208_ChIP-Seq_DFB_Human2.27524432
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.24624421
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.23604837
24* GABP_17652178_ChIP-ChIP_JURKAT_Human2.22263244
25AR_21909140_ChIP-Seq_LNCAP_Human2.17847519
26* ELK1_19687146_ChIP-ChIP_HELA_Human2.16531061
27EWS_26573619_Chip-Seq_HEK293_Human2.14595887
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.13029599
29PCGF2_27294783_Chip-Seq_ESCs_Mouse2.07381376
30EST1_17652178_ChIP-ChIP_JURKAT_Human2.02074016
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.98583689
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.97804932
33NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95753334
34GATA1_22025678_ChIP-Seq_K562_Human1.95620758
35E2F1_21310950_ChIP-Seq_MCF-7_Human1.89557872
36KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.88450849
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.85492554
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80669806
39ER_23166858_ChIP-Seq_MCF-7_Human1.75901608
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73001560
41MYC_19030024_ChIP-ChIP_MESCs_Mouse1.70755570
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.70152275
43IRF8_21731497_ChIP-ChIP_J774_Mouse1.70026445
44SUZ12_27294783_Chip-Seq_NPCs_Mouse1.69616435
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.68689234
46STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.68627195
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68294345
48NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.68260213
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.66439148
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.64938242
51TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.64254826
52TP63_17297297_ChIP-ChIP_HaCaT_Human1.64028392
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.63698366
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63293350
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.62989874
56RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62848368
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.61025940
58CREB1_15753290_ChIP-ChIP_HEK293T_Human1.60310361
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.58643596
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.55929048
61VDR_23849224_ChIP-Seq_CD4+_Human1.55821345
62CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.55057637
63MYC_19079543_ChIP-ChIP_MESCs_Mouse1.54643132
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.53925871
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53287347
66MYC_18358816_ChIP-ChIP_MESCs_Mouse1.52406060
67MYB_21317192_ChIP-Seq_ERMYB_Mouse1.51988492
68SMAD4_21799915_ChIP-Seq_A2780_Human1.50787155
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50421947
70BCAT_22108803_ChIP-Seq_LS180_Human1.49777365
71CBP_20019798_ChIP-Seq_JUKART_Human1.47291013
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47291013
73FOXP3_21729870_ChIP-Seq_TREG_Human1.45978085
74SALL1_21062744_ChIP-ChIP_HESCs_Human1.45213204
75SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.44574852
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.44292840
77TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43333822
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.43329566
79MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.43007806
80* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42096763
81CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.41929062
82* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40880045
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40679380
84STAT3_23295773_ChIP-Seq_U87_Human1.39766035
85PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37873695
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37760639
87NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37657719
88* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.37518950
89XRN2_22483619_ChIP-Seq_HELA_Human1.37039273
90TCF4_23295773_ChIP-Seq_U87_Human1.35652227
91PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35565900
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34830684
93NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34290824
94* SPI1_23547873_ChIP-Seq_NB4_Human1.34035463
95E2F1_18555785_ChIP-Seq_MESCs_Mouse1.33782104
96P53_22387025_ChIP-Seq_ESCs_Mouse1.33008288
97* CDX2_22108803_ChIP-Seq_LS180_Human1.31956824
98SRF_21415370_ChIP-Seq_HL-1_Mouse1.31189725
99CRX_20693478_ChIP-Seq_RETINA_Mouse1.30773059
100TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30745339
101DCP1A_22483619_ChIP-Seq_HELA_Human1.30076526
102AR_25329375_ChIP-Seq_VCAP_Human1.29027507
103TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28987995
104SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28147474
105ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28129935
106* NANOG_19829295_ChIP-Seq_ESCs_Human1.27811458
107* SOX2_19829295_ChIP-Seq_ESCs_Human1.27811458
108NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.27308425
109MYC_22102868_ChIP-Seq_BL_Human1.26990869
110PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.26754473
111E2F1_18555785_Chip-Seq_ESCs_Mouse1.26515151
112STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26136952
113* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.25925055
114ETS1_20019798_ChIP-Seq_JURKAT_Human1.25251770
115MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25154358
116KLF5_20875108_ChIP-Seq_MESCs_Mouse1.24901279
117P300_18555785_Chip-Seq_ESCs_Mouse1.24100568
118CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24042356
119FOXM1_26456572_ChIP-Seq_MCF-7_Human1.23466358
120TFEB_21752829_ChIP-Seq_HELA_Human1.23034810
121* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.22557531
122SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22204572
123WT1_19549856_ChIP-ChIP_CCG9911_Human1.22179270
124CMYC_18555785_Chip-Seq_ESCs_Mouse1.21878011
125TCF4_22108803_ChIP-Seq_LS180_Human1.21326671
126* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20869339
127FLI1_21867929_ChIP-Seq_TH2_Mouse1.20491251
128STAT3_18555785_Chip-Seq_ESCs_Mouse1.20049076
129MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19923168
130MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.19452681
131HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18235915
132OCT4_21477851_ChIP-Seq_ESCs_Mouse1.17697547
133HIF1A_21447827_ChIP-Seq_MCF-7_Human1.17650158
134PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.17388323
135STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.17148998
136FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16051181
137FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.15953597
138TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15672010
139CLOCK_20551151_ChIP-Seq_293T_Human1.15500940
140SOX2_18555785_Chip-Seq_ESCs_Mouse1.15281845
141MYB_26560356_Chip-Seq_TH2_Human1.14611773
142* IRF8_27001747_Chip-Seq_BMDM_Mouse1.14451610
143SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14119114
144STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.12991949
145FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12746963
146RUNX2_22187159_ChIP-Seq_PCA_Human1.11746258
147TP53_22573176_ChIP-Seq_HFKS_Human1.10668915
148STAT4_19710469_ChIP-ChIP_TH1__Mouse1.10209303
149TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09893650
150SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09832080
151EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08825431
152CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08657529
153OCT4_18555785_Chip-Seq_ESCs_Mouse1.08291068
154CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08009107
155FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07781503
156ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07315081
157POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07132917
158TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07132917
159GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06419593
160MYB_26560356_Chip-Seq_TH1_Human1.05801506
161EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05614278
162EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.04850802
163TTF2_22483619_ChIP-Seq_HELA_Human1.02817438
164TRIM28_21343339_ChIP-Seq_HEK293_Human1.02450959
165HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.98045738
166BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96892714
167SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94752254
168CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94748921
169ELK1_22589737_ChIP-Seq_MCF10A_Human0.91275815
170CIITA_25753668_ChIP-Seq_RAJI_Human0.90636751
171BRD4_25478319_ChIP-Seq_HGPS_Human0.88391927
172NOTCH1_21737748_ChIP-Seq_TLL_Human0.87850700
173* GABP_19822575_ChIP-Seq_HepG2_Human0.87338012
174KDM5A_27292631_Chip-Seq_BREAST_Human0.86024766
175GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85402295
176IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.85198680
177E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84958122
178PU_27001747_Chip-Seq_BMDM_Mouse0.84763362
179FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.83647312
180SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83316394
181CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82947400
182GATA3_27048872_Chip-Seq_THYMUS_Human0.82765151
183HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82721720
184SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.82343771
185SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.82343771

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.49609865
2MP0003195_calcinosis3.20907125
3MP0002102_abnormal_ear_morphology3.18108737
4MP0008057_abnormal_DNA_replication2.55921990
5MP0010094_abnormal_chromosome_stability2.42969368
6MP0002837_dystrophic_cardiac_calcinosis2.38662284
7MP0005367_renal/urinary_system_phenotyp2.30653804
8MP0000516_abnormal_urinary_system2.30653804
9MP0000372_irregular_coat_pigmentation2.26988418
10MP0001853_heart_inflammation2.24028932
11MP0010352_gastrointestinal_tract_polyps2.23682481
12MP0006054_spinal_hemorrhage2.22751539
13MP0006072_abnormal_retinal_apoptosis2.21456229
14MP0000427_abnormal_hair_cycle2.16542863
15MP0002396_abnormal_hematopoietic_system2.09801363
16MP0003693_abnormal_embryo_hatching2.08759250
17MP0002876_abnormal_thyroid_physiology2.08637691
18MP0008438_abnormal_cutaneous_collagen2.03648351
19MP0003183_abnormal_peptide_metabolism2.01650728
20MP0010386_abnormal_urinary_bladder1.97629512
21MP0004957_abnormal_blastocyst_morpholog1.96404394
22MP0003300_gastrointestinal_ulcer1.89752217
23MP0001835_abnormal_antigen_presentation1.82578640
24MP0010678_abnormal_skin_adnexa1.82552408
25MP0005646_abnormal_pituitary_gland1.81801089
26MP0003279_aneurysm1.81720228
27MP0002163_abnormal_gland_morphology1.79365889
28MP0009384_cardiac_valve_regurgitation1.75890628
29MP0000383_abnormal_hair_follicle1.75417069
30MP0003077_abnormal_cell_cycle1.72723001
31MP0005253_abnormal_eye_physiology1.71902890
32MP0005379_endocrine/exocrine_gland_phen1.66849097
33MP0002751_abnormal_autonomic_nervous1.66498732
34MP0009780_abnormal_chondrocyte_physiolo1.65875517
35MP0003436_decreased_susceptibility_to1.65081204
36MP0005084_abnormal_gallbladder_morpholo1.64014600
37MP0008058_abnormal_DNA_repair1.63147376
38MP0004808_abnormal_hematopoietic_stem1.62488889
39MP0001919_abnormal_reproductive_system1.59550232
40MP0002166_altered_tumor_susceptibility1.57754490
41MP0002138_abnormal_hepatobiliary_system1.56280669
42MP0005389_reproductive_system_phenotype1.56035510
43MP0003111_abnormal_nucleus_morphology1.54151161
44MP0002139_abnormal_hepatobiliary_system1.50035421
45MP0010368_abnormal_lymphatic_system1.48896831
46MP0003123_paternal_imprinting1.48152835
47MP0003566_abnormal_cell_adhesion1.45717232
48MP0004043_abnormal_pH_regulation1.43346309
49MP0002419_abnormal_innate_immunity1.42638629
50MP0003718_maternal_effect1.41352837
51MP0010234_abnormal_vibrissa_follicle1.41203221
52MP0008007_abnormal_cellular_replicative1.40488203
53MP0005551_abnormal_eye_electrophysiolog1.36162262
54MP0008877_abnormal_DNA_methylation1.34380466
55MP0005085_abnormal_gallbladder_physiolo1.34165157
56MP0002452_abnormal_antigen_presenting1.30665315
57MP0000685_abnormal_immune_system1.30643366
58MP0003763_abnormal_thymus_physiology1.29846600
59MP0001915_intracranial_hemorrhage1.29369097
60MP0003880_abnormal_central_pattern1.29047049
61MP0002877_abnormal_melanocyte_morpholog1.28421255
62MP0005187_abnormal_penis_morphology1.27982259
63MP0001800_abnormal_humoral_immune1.27423010
64MP0001790_abnormal_immune_system1.26483996
65MP0005387_immune_system_phenotype1.26483996
66MP0001764_abnormal_homeostasis1.26460362
67MP0005174_abnormal_tail_pigmentation1.25252049
68MP0004215_abnormal_myocardial_fiber1.24059490
69MP0000465_gastrointestinal_hemorrhage1.22969455
70MP0002933_joint_inflammation1.22108740
71MP0000647_abnormal_sebaceous_gland1.20732812
72MP0001756_abnormal_urination1.19911524
73MP0002638_abnormal_pupillary_reflex1.19785189
74MP0002420_abnormal_adaptive_immunity1.19304095
75MP0002254_reproductive_system_inflammat1.19246993
76MP0002060_abnormal_skin_morphology1.18584914
77MP0005671_abnormal_response_to1.17594739
78MP0001819_abnormal_immune_cell1.17016555
79MP0001984_abnormal_olfaction1.16992526
80MP0002938_white_spotting1.16464043
81MP0002928_abnormal_bile_duct1.16236552
82MP0002398_abnormal_bone_marrow1.14964014
83MP0005248_abnormal_Harderian_gland1.14783213
84MP0003646_muscle_fatigue1.14377884
85MP0001533_abnormal_skeleton_physiology1.14122034
86MP0005023_abnormal_wound_healing1.13483285
87MP0009053_abnormal_anal_canal1.13328270
88MP0003786_premature_aging1.12433484
89MP0001730_embryonic_growth_arrest1.12027314
90MP0010155_abnormal_intestine_physiology1.11397369
91MP0005025_abnormal_response_to1.11294594
92MP0002006_tumorigenesis1.11028719
93MP0002132_abnormal_respiratory_system1.10831007
94MP0005397_hematopoietic_system_phenotyp1.10647393
95MP0001545_abnormal_hematopoietic_system1.10647393
96MP0003252_abnormal_bile_duct1.10621201
97MP0000490_abnormal_crypts_of1.08405904
98MP0009785_altered_susceptibility_to1.06522543
99MP0005647_abnormal_sex_gland1.06390759
100MP0000689_abnormal_spleen_morphology1.05100972
101* MP0000350_abnormal_cell_proliferation1.04708311
102MP0005000_abnormal_immune_tolerance1.04511854
103MP0002723_abnormal_immune_serum1.04037269
104MP0003724_increased_susceptibility_to1.03745064
105MP0003186_abnormal_redox_activity1.03589390
106MP0003303_peritoneal_inflammation1.03341825
107MP0001879_abnormal_lymphatic_vessel1.02967447
108MP0003984_embryonic_growth_retardation1.02937570
109MP0002088_abnormal_embryonic_growth/wei1.02260886
110MP0001986_abnormal_taste_sensitivity1.00025577
111MP0003011_delayed_dark_adaptation0.98955446
112MP0004264_abnormal_extraembryonic_tissu0.98539062
113MP0002019_abnormal_tumor_incidence0.97449623
114MP0010307_abnormal_tumor_latency0.97443856
115MP0002148_abnormal_hypersensitivity_rea0.97248078
116MP0000750_abnormal_muscle_regeneration0.97247609
117MP0002722_abnormal_immune_system0.96978422
118MP0001929_abnormal_gametogenesis0.96821801
119MP0008875_abnormal_xenobiotic_pharmacok0.96592083
120MP0003943_abnormal_hepatobiliary_system0.96075379
121MP0001672_abnormal_embryogenesis/_devel0.95848671
122MP0005380_embryogenesis_phenotype0.95848671
123MP0005058_abnormal_lysosome_morphology0.95573331
124MP0004272_abnormal_basement_membrane0.95131273
125MP0003937_abnormal_limbs/digits/tail_de0.94808420
126MP0003448_altered_tumor_morphology0.94782599
127MP0002086_abnormal_extraembryonic_tissu0.94677391
128MP0003828_pulmonary_edema0.94524852
129MP0000716_abnormal_immune_system0.93835510
130MP0003890_abnormal_embryonic-extraembry0.93743762
131MP0008872_abnormal_physiological_respon0.93627628
132MP0002736_abnormal_nociception_after0.93495174
133MP0006276_abnormal_autonomic_nervous0.93386239
134MP0004147_increased_porphyrin_level0.93123043
135MP0001293_anophthalmia0.92736686
136MP0002160_abnormal_reproductive_system0.92146690
137MP0000569_abnormal_digit_pigmentation0.91717366
138MP0005395_other_phenotype0.91652557
139MP0005408_hypopigmentation0.91437086
140MP0002429_abnormal_blood_cell0.91066352
141MP0002090_abnormal_vision0.90746404
142MP0008775_abnormal_heart_ventricle0.90735797
143MP0001968_abnormal_touch/_nociception0.90612918
144MP0003283_abnormal_digestive_organ0.90334311
145MP0001845_abnormal_inflammatory_respons0.89819265
146MP0005464_abnormal_platelet_physiology0.89739118
147MP0009046_muscle_twitch0.89096146
148MP0000013_abnormal_adipose_tissue0.86690518
149MP0003121_genomic_imprinting0.86057947
150MP0004484_altered_response_of0.85343125
151MP0001485_abnormal_pinna_reflex0.85098278
152MP0005390_skeleton_phenotype0.83637055
153MP0001119_abnormal_female_reproductive0.83535677
154MP0003950_abnormal_plasma_membrane0.83025827
155MP0005266_abnormal_metabolism0.82294276
156MP0005076_abnormal_cell_differentiation0.82124640
157MP0005645_abnormal_hypothalamus_physiol0.81985025
158MP0002909_abnormal_adrenal_gland0.81584075
159MP0004084_abnormal_cardiac_muscle0.81531745
160MP0000631_abnormal_neuroendocrine_gland0.81349270
161MP0005275_abnormal_skin_tensile0.81166263
162MP0005220_abnormal_exocrine_pancreas0.81050758
163MP0006036_abnormal_mitochondrial_physio0.80523209
164MP0000858_altered_metastatic_potential0.80510496
165MP0001661_extended_life_span0.79605606
166MP0000653_abnormal_sex_gland0.79243036
167MP0001486_abnormal_startle_reflex0.78604358
168MP0005503_abnormal_tendon_morphology0.78371529
169MP0009697_abnormal_copulation0.78345581
170MP0000537_abnormal_urethra_morphology0.77734523
171MP0001191_abnormal_skin_condition0.77250487
172MP0002210_abnormal_sex_determination0.76257741
173MP0001243_abnormal_dermal_layer0.74796681
174MP0003136_yellow_coat_color0.74089438
175MP0002693_abnormal_pancreas_physiology0.73790224
176MP0005332_abnormal_amino_acid0.73605725
177MP0004134_abnormal_chest_morphology0.72406628
178MP0006082_CNS_inflammation0.71949784
179MP0005075_abnormal_melanosome_morpholog0.70655384
180MP0001145_abnormal_male_reproductive0.69846645
181MP0000538_abnormal_urinary_bladder0.69674823
182MP0002168_other_aberrant_phenotype0.68978764
183MP0002095_abnormal_skin_pigmentation0.68854633
184MP0006035_abnormal_mitochondrial_morpho0.66811259
185MP0000230_abnormal_systemic_arterial0.65715541
186MP0000613_abnormal_salivary_gland0.65704384

Predicted human phenotypes

RankGene SetZ-score
1Short middle phalanx of the 5th finger (HP:0004220)4.58927313
2Selective tooth agenesis (HP:0001592)3.93728253
3Methylmalonic acidemia (HP:0002912)3.65905168
4Tetraparesis (HP:0002273)3.55488288
5Thrombocytosis (HP:0001894)3.49413208
6Pancreatic cysts (HP:0001737)3.37685566
7Pancreatic fibrosis (HP:0100732)3.25404424
8Stomach cancer (HP:0012126)3.15103173
9Short 5th finger (HP:0009237)3.11415289
10Birth length less than 3rd percentile (HP:0003561)3.05519852
11Aplasia involving bones of the extremities (HP:0009825)3.05207276
12Aplasia involving bones of the upper limbs (HP:0009823)3.05207276
13Aplasia of the phalanges of the hand (HP:0009802)3.05207276
14Type 2 muscle fiber atrophy (HP:0003554)3.02433132
15Large for gestational age (HP:0001520)3.01143894
16True hermaphroditism (HP:0010459)2.96617082
17Abnormality of vitamin B metabolism (HP:0004340)2.89281331
18Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.84943666
19Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.84061825
20Recurrent viral infections (HP:0004429)2.82847292
21Abnormality of the renal cortex (HP:0011035)2.73581150
22Thyroiditis (HP:0100646)2.73008434
23Intestinal atresia (HP:0011100)2.72422899
24Prostate neoplasm (HP:0100787)2.71527915
25Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.65206597
26Poor head control (HP:0002421)2.62556696
27Calf muscle hypertrophy (HP:0008981)2.61640973
28Gaze-evoked nystagmus (HP:0000640)2.59123675
29Neoplasm of the adrenal cortex (HP:0100641)2.58966485
30Abnormality of the vitamin B12 metabolism (HP:0004341)2.56971003
31Cortical dysplasia (HP:0002539)2.55237087
32Abolished electroretinogram (ERG) (HP:0000550)2.54880282
33Hypothermia (HP:0002045)2.51734304
34Prominent metopic ridge (HP:0005487)2.50476228
35Abnormality of the labia minora (HP:0012880)2.49622339
36Colon cancer (HP:0003003)2.48324700
37Medial flaring of the eyebrow (HP:0010747)2.47535746
38Methylmalonic aciduria (HP:0012120)2.46515738
39Subacute progressive viral hepatitis (HP:0006572)2.46041190
40Abnormality of the phalanges of the 5th finger (HP:0004213)2.41940360
41Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.39446421
42Abnormality of aspartate family amino acid metabolism (HP:0010899)2.36840005
43Abnormality of DNA repair (HP:0003254)2.35684992
44Molar tooth sign on MRI (HP:0002419)2.34179731
45Abnormality of midbrain morphology (HP:0002418)2.34179731
46Nephronophthisis (HP:0000090)2.33679198
47Flared metaphyses (HP:0003015)2.33283677
48Cervical subluxation (HP:0003308)2.32557915
49Periodontitis (HP:0000704)2.32450870
50Viral hepatitis (HP:0006562)2.32259238
51Chromsome breakage (HP:0040012)2.32228932
52Ketoacidosis (HP:0001993)2.30877117
53Progressive macrocephaly (HP:0004481)2.29546323
54Renal cortical cysts (HP:0000803)2.28203441
55Abnormal delayed hypersensitivity skin test (HP:0002963)2.26455077
56Congenital sensorineural hearing impairment (HP:0008527)2.25500911
57Abnormality of the metopic suture (HP:0005556)2.25105232
58Muscle hypertrophy of the lower extremities (HP:0008968)2.24904825
59Hyperinsulinemic hypoglycemia (HP:0000825)2.24204288
60Astrocytoma (HP:0009592)2.21901101
61Abnormality of the astrocytes (HP:0100707)2.21901101
62Glioma (HP:0009733)2.21199515
63Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.20648894
64Irregular epiphyses (HP:0010582)2.20538038
65Abnormality of the columella (HP:0009929)2.20478958
66Syringomyelia (HP:0003396)2.20471189
67Spinal cord lesions (HP:0100561)2.20471189
68Hematochezia (HP:0002573)2.18493575
69Abnormality of T cell physiology (HP:0011840)2.17552593
70Amyotrophic lateral sclerosis (HP:0007354)2.17119984
71Ependymoma (HP:0002888)2.16935611
72Decreased muscle mass (HP:0003199)2.16501509
73Neoplasm of the adrenal gland (HP:0100631)2.15553625
74Autoimmune thrombocytopenia (HP:0001973)2.15529011
75Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.15464076
76Absent frontal sinuses (HP:0002688)2.14328456
77Increased neuronal autofluorescent lipopigment (HP:0002074)2.12630901
78Aortic regurgitation (HP:0001659)2.12614657
79Abnormality of the renal medulla (HP:0100957)2.12454973
80Attenuation of retinal blood vessels (HP:0007843)2.11188183
8111 pairs of ribs (HP:0000878)2.10680029
82Hyperglycinemia (HP:0002154)2.10412488
83Volvulus (HP:0002580)2.09443362
84Abnormal foot bone ossification (HP:0010675)2.07154418
85Hypoglycemic seizures (HP:0002173)2.06792999
86Abnormality of macrophages (HP:0004311)2.05399564
87Recurrent bacterial skin infections (HP:0005406)2.04995154
88Muscle fiber atrophy (HP:0100295)2.03834458
89Abnormality of methionine metabolism (HP:0010901)2.03096828
90Furrowed tongue (HP:0000221)2.02910792
91Hyperventilation (HP:0002883)2.02665485
92Duplicated collecting system (HP:0000081)2.00306409
93Recurrent abscess formation (HP:0002722)1.99178871
94Abnormality of chromosome stability (HP:0003220)1.98043742
95Leukopenia (HP:0001882)1.97270694
96Osteolytic defects of the hand bones (HP:0009699)1.97252216
97Osteolytic defects of the phalanges of the hand (HP:0009771)1.97252216
98Increased mean platelet volume (HP:0011877)1.97171176
99Hyperglycemia (HP:0003074)1.95095857
100Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.94554096
101Basal ganglia calcification (HP:0002135)1.94389947
102Rhabdomyosarcoma (HP:0002859)1.91588087
103Eosinophilia (HP:0001880)1.91477515
104Acute necrotizing encephalopathy (HP:0006965)1.90945757
105Premature loss of primary teeth (HP:0006323)1.90456944
106Cystic liver disease (HP:0006706)1.90023200
107Reticulocytopenia (HP:0001896)1.89993961
108Abnormal platelet volume (HP:0011876)1.89554027
109Tubulointerstitial nephritis (HP:0001970)1.89049410
110Abnormal rod and cone electroretinograms (HP:0008323)1.88336679
111Clubbing of toes (HP:0100760)1.87834043
112Degeneration of anterior horn cells (HP:0002398)1.87770486
113Abnormality of the anterior horn cell (HP:0006802)1.87770486
114Ketosis (HP:0001946)1.87480595
115Granulocytopenia (HP:0001913)1.87323980
116Broad-based gait (HP:0002136)1.86912371
117Aqueductal stenosis (HP:0002410)1.86906392
118Broad alveolar ridges (HP:0000187)1.86769933
119Hamartoma of the eye (HP:0010568)1.86689836
120Fair hair (HP:0002286)1.86509336
121Congenital stationary night blindness (HP:0007642)1.84542824
122Abnormality of the renal collecting system (HP:0004742)1.83775599
123Breast carcinoma (HP:0003002)1.82829855
124Adactyly (HP:0009776)1.81508727
125Curly hair (HP:0002212)1.81468202
126Panhypogammaglobulinemia (HP:0003139)1.81338095
127Vacuolated lymphocytes (HP:0001922)1.80825306
128Congenital, generalized hypertrichosis (HP:0004540)1.80515073
129IgM deficiency (HP:0002850)1.79124681
130Aplasia/Hypoplasia of the uvula (HP:0010293)1.78997123
131Submucous cleft hard palate (HP:0000176)1.78839152
132Abnormality of vitamin metabolism (HP:0100508)1.78513825
133Congenital primary aphakia (HP:0007707)1.78194643
134Stomatitis (HP:0010280)1.77936369
135Aplasia/Hypoplasia of the tongue (HP:0010295)1.77719662
136Steatorrhea (HP:0002570)1.76200879
137Abnormality of serum amino acid levels (HP:0003112)1.74815113
138Abnormality of the prostate (HP:0008775)1.74618418
139Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.74497702
140Vertebral hypoplasia (HP:0008417)1.74497702
141Aplasia/Hypoplasia of the hallux (HP:0008362)1.73867826
142Aplasia/Hypoplasia of the tibia (HP:0005772)1.73195631
143Increased cerebral lipofuscin (HP:0011813)1.72811830
144Spondylolisthesis (HP:0003302)1.72511588
145Male pseudohermaphroditism (HP:0000037)1.72045690
146Acute encephalopathy (HP:0006846)1.71872395
147Abnormal biliary tract physiology (HP:0012439)1.71853425
148Bile duct proliferation (HP:0001408)1.71853425
149Pancreatic islet-cell hyperplasia (HP:0004510)1.71119929
150Supernumerary spleens (HP:0009799)1.70925951
151Genital tract atresia (HP:0001827)1.70720096
152Agammaglobulinemia (HP:0004432)1.69241519
153Beaking of vertebral bodies (HP:0004568)1.69212865
154Short 4th metacarpal (HP:0010044)1.68319302
155Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.68319302
156Widely spaced teeth (HP:0000687)1.68287768
157Disproportionate short-trunk short stature (HP:0003521)1.67601499
158Nephrogenic diabetes insipidus (HP:0009806)1.67559101
159Sloping forehead (HP:0000340)1.67462791
160Hypoglycemic coma (HP:0001325)1.66956479
161Increased CSF lactate (HP:0002490)1.66925103
162Cupped ribs (HP:0000887)1.66711437
163Abnormality of the phalanges of the 2nd finger (HP:0009541)1.65876543
164Acute myeloid leukemia (HP:0004808)1.65774815
165Interstitial pulmonary disease (HP:0006530)1.65537212
166Abnormal biliary tract morphology (HP:0012440)1.65499205
167Tubular atrophy (HP:0000092)1.65075974
168Abnormality of B cell number (HP:0010975)1.64982520
169B lymphocytopenia (HP:0010976)1.64982520
170Constricted visual fields (HP:0001133)1.64757705
171Short hallux (HP:0010109)1.64103932
172Gait imbalance (HP:0002141)1.63259542
173Broad face (HP:0000283)1.62644204
174Mucopolysacchariduria (HP:0008155)1.62593129
175Urinary glycosaminoglycan excretion (HP:0003541)1.62593129
176Lymphoma (HP:0002665)1.62165680
177Abnormality of skull ossification (HP:0002703)1.61994489
178Abnormality of T cell number (HP:0011839)1.61717095
179Dry hair (HP:0011359)1.61292054
180Oculomotor apraxia (HP:0000657)1.61003996
181Osteomyelitis (HP:0002754)1.60749821
182Abnormality of T cells (HP:0002843)1.60541237
183Small epiphyses (HP:0010585)1.60034126
184Biliary tract neoplasm (HP:0100574)1.59718801
185Abnormality of cells of the lymphoid lineage (HP:0012140)1.58918796
186Neutropenia (HP:0001875)1.57881030
187Abnormality of the alveolar ridges (HP:0006477)1.57200487
188Deviation of the thumb (HP:0009603)1.55870147
189Agnosia (HP:0010524)1.55607323
190Premature rupture of membranes (HP:0001788)1.55592266

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.59766336
2MAP4K23.47783632
3EIF2AK13.29040727
4RPS6KA43.04724597
5NUAK12.51116230
6MAP2K32.46732762
7BMPR1B2.42145983
8TRIM282.33968159
9MAP3K142.12930071
10TNIK2.06967170
11TAOK32.03780056
12PBK2.01913308
13STK101.96403547
14PLK21.93996992
15ZAK1.89835555
16WNK31.80457555
17PASK1.77630395
18FGFR21.74162953
19FRK1.73643847
20TYK21.71067062
21GRK11.70305111
22PINK11.62733281
23BRSK21.55803439
24MKNK11.53675715
25ACVR1B1.53567861
26CASK1.51619654
27EIF2AK21.51429154
28TSSK61.44836715
29CDK61.43543855
30IRAK31.41665319
31TRPM71.41286019
32PIK3CA1.40458970
33WEE11.39374553
34AKT31.38090980
35TGFBR11.35421813
36STK41.34819313
37ATR1.34624218
38MAP4K11.32671784
39PAK31.32579981
40EIF2AK31.31997310
41TBK11.29483972
42JAK31.28269396
43ADRBK21.28083440
44SCYL21.25461381
45STK391.21410753
46STK241.21303731
47JAK11.20102254
48MAP3K31.14511580
49CDK41.13551651
50OXSR11.13304275
51TGFBR21.11806453
52NEK91.11661612
53FLT31.11288296
54NEK61.08261221
55ERN11.06968597
56RPS6KB21.05548490
57TTN1.04615067
58AURKB1.03523365
59PLK41.02749760
60STK31.02732430
61MAP3K41.01915633
62PNCK1.01227319
63PIK3CG0.99039251
64IKBKB0.97716901
65CDK120.97330292
66BUB10.94471186
67INSRR0.94458732
68MAPK120.93719457
69KIT0.92807081
70CHUK0.92271742
71VRK10.92142646
72CSNK1G10.91089075
73PLK30.90790390
74MAP3K80.90493628
75PRKCE0.89799869
76PAK40.88443949
77BCR0.87687763
78LRRK20.87463875
79BRD40.87275557
80IRAK40.87138807
81TAF10.87006148
82MAPK130.86811881
83SRPK10.84319028
84MAPK70.83280133
85CSF1R0.81646636
86ERBB30.81571226
87CSNK1G20.81483792
88NEK10.81353692
89KDR0.79387121
90PLK10.76659302
91PIM10.76329062
92NEK20.74638714
93CLK10.73700676
94EPHA30.71878964
95FGFR10.70650823
96STK38L0.70520047
97FGFR30.69679655
98BTK0.68620112
99CSNK1G30.68234440
100NLK0.67964790
101MKNK20.67469186
102CAMKK20.66460075
103CSNK1A1L0.65476576
104MST40.65075671
105IKBKE0.64897433
106ATM0.64048682
107OBSCN0.63818216
108BCKDK0.63389611
109BRSK10.63294665
110PKN20.63157460
111DYRK30.61093261
112BMPR20.60894463
113TTK0.60789289
114CHEK10.60240881
115RPS6KA50.58774239
116PDK20.58586302
117TEC0.57760219
118YES10.57750816
119EPHA40.57674399
120PHKG20.57390647
121PHKG10.57390647
122SGK20.55713823
123CDK70.54648839
124ERBB40.53486996
125MAP2K60.53423068
126MAPKAPK50.52598475
127CSK0.51009738
128TESK10.50562157
129MAP3K100.50534924
130RPS6KB10.50093250
131TLK10.48755841
132DYRK1A0.47435883
133FER0.47329370
134TAOK10.45038818
135FGFR40.44581707
136PTK60.44127596
137PRKCQ0.43959925
138CHEK20.43954239
139LYN0.43737094
140MUSK0.42079919
141TXK0.41636210
142PTK2B0.40988624
143CSNK1A10.36289557
144WNK40.35661317
145ADRBK10.33106657
146NTRK30.30442887
147IRAK10.30383161
148PRKACB0.30012103
149ABL10.29111930
150PRKCG0.29086250
151PRKAA20.28894335
152ITK0.28827873
153CDK30.27271143
154CSNK1D0.27227959
155PRKG10.26054286
156IGF1R0.25477317
157EGFR0.23918179
158CAMK1G0.23685956

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.66401169
2Mismatch repair_Homo sapiens_hsa034303.24335390
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.12697410
4Propanoate metabolism_Homo sapiens_hsa006402.87530654
5Non-homologous end-joining_Homo sapiens_hsa034502.60734721
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.47753418
7Butanoate metabolism_Homo sapiens_hsa006502.44402748
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.43585509
9Nucleotide excision repair_Homo sapiens_hsa034202.41211518
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.23884532
11Homologous recombination_Homo sapiens_hsa034402.08562653
12SNARE interactions in vesicular transport_Homo sapiens_hsa041302.05254601
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.99764939
14Cell cycle_Homo sapiens_hsa041101.97139395
15Nitrogen metabolism_Homo sapiens_hsa009101.91700864
16Legionellosis_Homo sapiens_hsa051341.89563121
17One carbon pool by folate_Homo sapiens_hsa006701.85776737
18Fatty acid elongation_Homo sapiens_hsa000621.78698152
19Antigen processing and presentation_Homo sapiens_hsa046121.78337876
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.77410263
21Base excision repair_Homo sapiens_hsa034101.76126319
22Tryptophan metabolism_Homo sapiens_hsa003801.65205677
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.62501245
24Small cell lung cancer_Homo sapiens_hsa052221.61875333
25Phototransduction_Homo sapiens_hsa047441.58943437
26NF-kappa B signaling pathway_Homo sapiens_hsa040641.57876467
27Peroxisome_Homo sapiens_hsa041461.55844853
28RNA transport_Homo sapiens_hsa030131.45212470
29Herpes simplex infection_Homo sapiens_hsa051681.44140822
30Leishmaniasis_Homo sapiens_hsa051401.43597657
31Toxoplasmosis_Homo sapiens_hsa051451.40791541
32RNA degradation_Homo sapiens_hsa030181.40173450
33Spliceosome_Homo sapiens_hsa030401.37955800
34NOD-like receptor signaling pathway_Homo sapiens_hsa046211.37694436
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.37606550
36Protein export_Homo sapiens_hsa030601.34397611
37Measles_Homo sapiens_hsa051621.33533889
38Proteasome_Homo sapiens_hsa030501.32223334
39p53 signaling pathway_Homo sapiens_hsa041151.30371672
40Primary immunodeficiency_Homo sapiens_hsa053401.25763250
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25200407
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.24354716
43Malaria_Homo sapiens_hsa051441.22088796
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.20476416
45Epstein-Barr virus infection_Homo sapiens_hsa051691.19599408
46Intestinal immune network for IgA production_Homo sapiens_hsa046721.18014222
47Fanconi anemia pathway_Homo sapiens_hsa034601.17680033
48Viral carcinogenesis_Homo sapiens_hsa052031.16800604
49Pyrimidine metabolism_Homo sapiens_hsa002401.15601175
50Primary bile acid biosynthesis_Homo sapiens_hsa001201.14712215
51Regulation of autophagy_Homo sapiens_hsa041401.13518821
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13505596
53Drug metabolism - other enzymes_Homo sapiens_hsa009831.13270199
54Oxidative phosphorylation_Homo sapiens_hsa001901.09999580
55N-Glycan biosynthesis_Homo sapiens_hsa005101.08753162
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.08389096
57Selenocompound metabolism_Homo sapiens_hsa004501.06786784
58Pertussis_Homo sapiens_hsa051331.04889918
59Taste transduction_Homo sapiens_hsa047421.03169938
60Fatty acid degradation_Homo sapiens_hsa000711.02482235
61Apoptosis_Homo sapiens_hsa042101.02289424
62Circadian rhythm_Homo sapiens_hsa047101.01943609
63Type I diabetes mellitus_Homo sapiens_hsa049401.01646359
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01392005
65Linoleic acid metabolism_Homo sapiens_hsa005911.00296990
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00197749
67RNA polymerase_Homo sapiens_hsa030200.98929563
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.98025061
69TNF signaling pathway_Homo sapiens_hsa046680.97319141
70Ether lipid metabolism_Homo sapiens_hsa005650.96628733
71Lysine degradation_Homo sapiens_hsa003100.96279920
72Viral myocarditis_Homo sapiens_hsa054160.92945093
73Fatty acid metabolism_Homo sapiens_hsa012120.92889379
74Influenza A_Homo sapiens_hsa051640.91405358
75Systemic lupus erythematosus_Homo sapiens_hsa053220.91381819
76Retinol metabolism_Homo sapiens_hsa008300.91095416
77Toll-like receptor signaling pathway_Homo sapiens_hsa046200.90836497
78Osteoclast differentiation_Homo sapiens_hsa043800.88283147
79beta-Alanine metabolism_Homo sapiens_hsa004100.86981379
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.86592479
81Leukocyte transendothelial migration_Homo sapiens_hsa046700.85848071
82Asthma_Homo sapiens_hsa053100.84401203
83Other glycan degradation_Homo sapiens_hsa005110.83989061
84Basal transcription factors_Homo sapiens_hsa030220.83428052
85B cell receptor signaling pathway_Homo sapiens_hsa046620.82972246
86Pentose phosphate pathway_Homo sapiens_hsa000300.82828646
87HTLV-I infection_Homo sapiens_hsa051660.81765199
88Steroid biosynthesis_Homo sapiens_hsa001000.81139210
89Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.81133353
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79729163
91Sulfur metabolism_Homo sapiens_hsa009200.79571649
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79543193
93Caffeine metabolism_Homo sapiens_hsa002320.79082598
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.78715221
95Starch and sucrose metabolism_Homo sapiens_hsa005000.78017430
96Collecting duct acid secretion_Homo sapiens_hsa049660.76775723
97Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76502446
98Hepatitis B_Homo sapiens_hsa051610.76432585
99Hematopoietic cell lineage_Homo sapiens_hsa046400.75229033
100Shigellosis_Homo sapiens_hsa051310.73278885
101Chronic myeloid leukemia_Homo sapiens_hsa052200.72623821
102ABC transporters_Homo sapiens_hsa020100.72204109
103ECM-receptor interaction_Homo sapiens_hsa045120.71688656
104Sphingolipid metabolism_Homo sapiens_hsa006000.70963654
105Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69768044
106Maturity onset diabetes of the young_Homo sapiens_hsa049500.69688561
107MicroRNAs in cancer_Homo sapiens_hsa052060.69390507
108mRNA surveillance pathway_Homo sapiens_hsa030150.68901127
109Dorso-ventral axis formation_Homo sapiens_hsa043200.68757230
110Olfactory transduction_Homo sapiens_hsa047400.66536669
111Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66024734
112Graft-versus-host disease_Homo sapiens_hsa053320.65553308
113Parkinsons disease_Homo sapiens_hsa050120.65329472
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64059326
115Mineral absorption_Homo sapiens_hsa049780.63975027
116Ribosome_Homo sapiens_hsa030100.62834169
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62718619
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61370792
119Allograft rejection_Homo sapiens_hsa053300.60027838
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59276146
121Pancreatic cancer_Homo sapiens_hsa052120.59032286
122Galactose metabolism_Homo sapiens_hsa000520.58396415
123Renin-angiotensin system_Homo sapiens_hsa046140.57079440
124Tuberculosis_Homo sapiens_hsa051520.56218035
125Adherens junction_Homo sapiens_hsa045200.55767293
126Lysosome_Homo sapiens_hsa041420.55603927
127Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55289235
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54853395
129Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54489061
130Vitamin B6 metabolism_Homo sapiens_hsa007500.54442456
131Glycosaminoglycan degradation_Homo sapiens_hsa005310.53891555
132Glutathione metabolism_Homo sapiens_hsa004800.53795830
133Metabolic pathways_Homo sapiens_hsa011000.52270091
134Hepatitis C_Homo sapiens_hsa051600.50993312
135Purine metabolism_Homo sapiens_hsa002300.49873929
136Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49675406
137Jak-STAT signaling pathway_Homo sapiens_hsa046300.49634292
138TGF-beta signaling pathway_Homo sapiens_hsa043500.48450156
139Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48166686
140Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47784103
141Oocyte meiosis_Homo sapiens_hsa041140.47223267
142Glycerolipid metabolism_Homo sapiens_hsa005610.46935366
143Biosynthesis of amino acids_Homo sapiens_hsa012300.46208712
144Chemical carcinogenesis_Homo sapiens_hsa052040.45622084
145Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45618782
146Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42525401
147Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.41098031
148Phagosome_Homo sapiens_hsa041450.40708782
149Autoimmune thyroid disease_Homo sapiens_hsa053200.39188995
150Proteoglycans in cancer_Homo sapiens_hsa052050.38140557
151Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38115998
152Insulin secretion_Homo sapiens_hsa049110.35353710
153Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34972949
154Nicotine addiction_Homo sapiens_hsa050330.33591505
155Serotonergic synapse_Homo sapiens_hsa047260.33195258
156Pyruvate metabolism_Homo sapiens_hsa006200.32484593
157Rheumatoid arthritis_Homo sapiens_hsa053230.32410743
158Arachidonic acid metabolism_Homo sapiens_hsa005900.31262005
159Vitamin digestion and absorption_Homo sapiens_hsa049770.30765250
160Alzheimers disease_Homo sapiens_hsa050100.27639280
161Huntingtons disease_Homo sapiens_hsa050160.23773254
162Circadian entrainment_Homo sapiens_hsa047130.22885617

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